MUC21

Summary

Gene Symbol: MUC21
Description: mucin 21, cell surface associated
Alias: C6orf205, KMQK697, MUC-21, mucin-21, epiglycanin
Species: human

Top Publications

  1. pmc Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells
    Ma del Rocío Banos-Lara
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mediators Inflamm 2015:347292. 2015
  2. doi Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
    Veronika Vymetalkova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, 14200 Prague, Czech Republic
    Carcinogenesis . 2016
  3. ncbi Tumor-host interactions regulate glucocorticoid-mediated epiglycanin expression in TA3Ha murine mammary carcinoma cells
    Torunn Thingstad
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Tumour Biol 24:116-29. 2003
  4. ncbi Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma
    Rongshan Li
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Arch Pathol Lab Med 128:1412-7. 2004
  5. ncbi Different progression of tumor xenografts between mucin-producing and mucin-non-producing mammary adenocarcinoma-bearing mice
    Ippei Sugihara
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kyoto, Japan
    Cancer Res 66:6175-82. 2006
  6. pmc Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
    Emmanuelle Genin
    INSERM U, Paris, France
    Orphanet J Rare Dis 6:52. 2011
  7. doi A genome-wide association study identifies two new risk loci for Graves' disease
    Xun Chu
    State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 43:897-901. 2011
  8. doi Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies
    Yuan Tian
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Glycobiology 22:1218-26. 2012
  9. pmc Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort
    Linlu Zhao
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale Schools of Public Health and Medicine, New Haven, CT, USA Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
    Ann Hum Genet 77:277-87. 2013
  10. ncbi Specificity studies of an antibody developed against a mucin-type glycoprotein
    S Haavik
    University of Bergen, Department of Pharmacology, Norway
    Glycoconj J 16:229-36. 1999

Scientific Experts

  • Emmanuelle Genin
  • S Haavik
  • Veronika Polakova Vymetalkova
  • Yuri Yi
  • Mika Kamata-Sakurai
  • Kyoko Okada
  • Kaori Denda-Nagai
  • Tatsuro Irimura
  • Yuichi Itoh
  • Munetoyo Toda
  • Ma del Rocío Banos-Lara
  • Linlu Zhao
  • Yuan Tian
  • Xun Chu
  • Minako Hijikata
  • Katrin Ishii-Schrade
  • Hiroshi Nakada
  • Mizue Inoue
  • Ippei Sugihara
  • Rongshan Li
  • Torunn Thingstad
  • Antonieta Guerrero-Plata
  • Boyang Piao
  • John F Codington
  • Andrew T Dewan
  • Michael B Bracken
  • Tatsuya Tsukui
  • Shoji Nakamori
  • Hai Feng Wang
  • Jun Liang
  • Bing Li Liu
  • Guo Yue Yuan
  • Wei hua Sun
  • Sai Juan Chen
  • Naoto Keicho
  • Ping Li
  • Yong De Peng
  • Huai Dong Song
  • Goh Tanaka
  • Guan Qi Gao
  • Zhi yi Song
  • Guang Ning
  • Ikumi Matsushita
  • Ting Guo
  • Shuang Xia Zhao
  • Wei Wei Sun
  • Jia Lun Chen
  • Xiao Mei Zhang
  • Cui Cui Guo
  • Xiao Na Zhang
  • Zhi Quan Wang
  • Qing Su
  • Arata Azuma
  • Liming Liang
  • Jing Yi Shi
  • Shao Ying Yang
  • Shoji Kudoh
  • Katsushi Tokunaga
  • Cai Yan Zou
  • Li bin Liu
  • Wei Huang
  • Bing Han
  • Fei Sun
  • Sakae Homma
  • Huang Ming Cao
  • Tomoko Tsuchiya
  • Zhao Hui Gu
  • Wei Liu
  • Jin xiu Shi
  • Zhu Chen
  • Qiu Hua Huang
  • Min Shen
  • Jun Hua Ma
  • Li Qiong Xue
  • Chang Gui Li
  • He Jiang
  • Yoichiro Kobashi
  • Yoshio Taguchi
  • Hideyuki Ito
  • Fang Xie
  • Ming Zhan
  • Wen Hua Du
  • Chun Ming Pan
  • Gang Chen
  • Chun lin Zuo
  • Jia jun Zhao
  • Jun Ohashi
  • Daisuke Sugiura
  • Akihiro Iguchi
  • Tomoko Itoh

Detail Information

Publications15

  1. pmc Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells
    Ma del Rocío Banos-Lara
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mediators Inflamm 2015:347292. 2015
    ..MUC expression by RSV and hMPV differs significantly, as we observed a stronger induction of MUC8, MUC15, MUC20, MUC21, and MUC22 by RSV infection while the expression of MUC1, MUC2, and MUC5B was dominated by the infection with hMPV...
  2. doi Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
    Veronika Vymetalkova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, 14200 Prague, Czech Republic
    Carcinogenesis . 2016
    ..Patients carrying the CC genotype of rs886403 in MUC21 displayed a shorter survival and higher recurrence risk when compared with TT carriers [overall survival (OS): ..
  3. ncbi Tumor-host interactions regulate glucocorticoid-mediated epiglycanin expression in TA3Ha murine mammary carcinoma cells
    Torunn Thingstad
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Tumour Biol 24:116-29. 2003
    The mucin-type glycoprotein epiglycanin is highly expressed on the cell surface of TA3Ha mouse mammary carcinoma cells if the cells are maintained by serial intraperitoneal passage in mice...
  4. ncbi Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma
    Rongshan Li
    Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Arch Pathol Lab Med 128:1412-7. 2004
    Human carcinoma-associated antigen (HCA) is a mucin glycoprotein recognized by antibodies raised against epiglycanin, the latter having been originally purified from mouse mammary carcinoma cells...
  5. ncbi Different progression of tumor xenografts between mucin-producing and mucin-non-producing mammary adenocarcinoma-bearing mice
    Ippei Sugihara
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kyoto, Japan
    Cancer Res 66:6175-82. 2006
    ..of COX2 mRNA and protein and production of PGE2 were elevated in peritoneal macrophages stimulated with epiglycanin, which is a mucin-like glycoprotein produced by TA3-Ha cells. S.c...
  6. pmc Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
    Emmanuelle Genin
    INSERM U, Paris, France
    Orphanet J Rare Dis 6:52. 2011
    ..Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described...
  7. doi A genome-wide association study identifies two new risk loci for Graves' disease
    Xun Chu
    State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 43:897-901. 2011
    ..Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease...
  8. doi Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies
    Yuan Tian
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Glycobiology 22:1218-26. 2012
    Monoclonal antibodies (mAbs) against mucin 21 (MUC21), a human counterpart of mouse epiglycanin/Muc21, were prepared using human embryonic kidney 293 cells transfected with MUC21 as the immunogen...
  9. pmc Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort
    Linlu Zhao
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale Schools of Public Health and Medicine, New Haven, CT, USA Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
    Ann Hum Genet 77:277-87. 2013
    ..Several variants were suggestively replicated in SOPHIA. The discovered SNPs and copy-number variable regions present interesting candidate genetic variants for pre-eclampsia that warrant further replication and investigation. ..
  10. ncbi Specificity studies of an antibody developed against a mucin-type glycoprotein
    S Haavik
    University of Bergen, Department of Pharmacology, Norway
    Glycoconj J 16:229-36. 1999
    The specificity of a new anti-epiglycanin antibody (AE-3) which recognizes a mucin-type glycoprotein, the Human Carcinoma Antigen, found in the blood of patients with carcinomas, was studied...
  11. ncbi Immunologic quantitation of the carcinoma specific human carcinoma antigen in clinical samples
    John F Codington
    Boston Biomedical Research Institute, Boston, Massachusetts 02472, USA
    Cancer 94:803-13. 2002
    Based on the cross-reactivity of the human carcinoma antigen, HCA, with epiglycanin, a mouse mammary carcinoma cell surface glycoprotein, HCA has been detected in the tissue and blood of patients with every type of epithelium-derived ..
  12. ncbi Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin
    Yuichi Itoh
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Glycobiology 18:74-83. 2008
    The gene for the human orthologue of mouse epiglycanin, a mucin expressed on mammary carcinoma TA3-Ha cells but not TA3-St cells, was identified by homology search to a mouse epiglycanin cDNA fragment identified by representational ..
  13. doi Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells
    Munetoyo Toda
    Department of Biotechnology, Kyoto Sangyo University, Kamigamo Motoyama, Kita ku, Kyoto 603 8555, Japan
    Biochem J 417:673-83. 2009
    ..Mouse mammary adenocarcinoma cells, TA3-Ha, produce a mucin named epiglycanin, but a subline of them, TA3-St, does not. Epiglycanin binds to CD22 and inhibits B-cell signalling in vitro...
  14. pmc Mucin 21/epiglycanin modulates cell adhesion
    Yuri Yi
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 285:21233-40. 2010
    The molecular structure of mouse Mucin 21 (Muc21)/epiglycanin is proposed to have 98 tandem repeats of 15 amino acids and three exceptional repeats with 12 or 13 amino acids each, followed by a stem domain, a transmembrane domain, and a ..
  15. doi Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis
    Minako Hijikata
    Department of Respiratory Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo 162 8655, Japan
    Hum Genet 129:117-28. 2011
    ..and PBMUCL2) in the candidate region, which form a mucin-like gene cluster together with two adjacent genes, MUC21 and DPCR1...