MUC17

Summary

Gene Symbol: MUC17
Description: mucin 17, cell surface associated
Alias: MUC-17, MUC-3, MUC3, mucin-17, membrane mucin MUC17, secreted mucin MUC17, small intestinal mucin MUC3, small intestinal mucin-3
Species: human

Top Publications

  1. ncbi Prognostic value of mucins in the classification of ampullary carcinomas
    Friedrich P Paulsen
    Department of Anatomy and Cell Biology, Martin Luther University of Halle Wittenberg, Saale, Germany
    Hum Pathol 37:160-7. 2006
  2. ncbi MUC17, a novel membrane-tethered mucin
    James R Gum
    Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 291:466-75. 2002
  3. ncbi Characterization of human mucin MUC17. Complete coding sequence and organization
    Nicolas Moniaux
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 281:23676-85. 2006
  4. pmc Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon
    Shantibhusan Senapati
    Department of Biochemistry and Molecular Biology, University of Nebraska, Omaha, Nebraska, USA
    J Clin Pathol 63:702-7. 2010
  5. pmc DNA methylation and histone H3-K9 modifications contribute to MUC17 expression
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Glycobiology 21:247-56. 2011
  6. pmc Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity
    Silvia Resta-Lenert
    Department of Medicine, University of California San Diego, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1144-55. 2011
  7. ncbi Molecular characterization of a major high molecular weight mucin from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Glycobiology 7:965-73. 1997
  8. ncbi Two novel mucin genes down-regulated in colorectal cancer identified by differential display
    S J Williams
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cancer Res 59:4083-9. 1999
  9. ncbi Mucins and mucin binding proteins in colorectal cancer
    James C Byrd
    The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
    Cancer Metastasis Rev 23:77-99. 2004
  10. ncbi Molecular analysis of colonic transformation in the ileum after total colectomy in rats
    Kouhei Fukushima
    Department of Surgery, Tohoku University, Graduate School of Medicine
    Surgery 140:93-9. 2006

Research Grants

  1. Michael A Hollingsworth; Fiscal Year: 2015
  2. Production of human MUC17 (CRD1-L-CRD2) recombinant protein in rice for the treat
    Ning Huang; Fiscal Year: 2013
  3. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
  4. GLYCOCONJUGATES IN PANCREATIC CANCER
    Young Kim; Fiscal Year: 2002
  5. Novel Proteins for Treatment of Bowel Diseases
    ROBERT HEINRIKSON; Fiscal Year: 2005
  6. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
  7. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
  8. MUCIN SECRETION IN COLUMNAR EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
  9. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
  10. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi Prognostic value of mucins in the classification of ampullary carcinomas
    Friedrich P Paulsen
    Department of Anatomy and Cell Biology, Martin Luther University of Halle Wittenberg, Saale, Germany
    Hum Pathol 37:160-7. 2006
    ..The samples investigated originated from 30 autopsy cases. Mucins MUC1, MUC3, MUC4, MUC5AC, MUC5B, MUC6, MUC7, and MUC8 were expressed in the ampulla of Vater...
  2. ncbi MUC17, a novel membrane-tethered mucin
    James R Gum
    Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 291:466-75. 2002
    ..In this paper we describe a large membrane mucin expressed in the normal intestine. This novel mucin, designated MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like ..
  3. ncbi Characterization of human mucin MUC17. Complete coding sequence and organization
    Nicolas Moniaux
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 281:23676-85. 2006
    ..the completed coding sequence and genomic organization of the previously published partial cDNA sequence of MUC17. Rapid amplification of cDNA ends with PCR, sequences from the Human Genome databases, and in vitro transcription/..
  4. pmc Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon
    Shantibhusan Senapati
    Department of Biochemistry and Molecular Biology, University of Nebraska, Omaha, Nebraska, USA
    J Clin Pathol 63:702-7. 2010
    To determine the cellular location and expression of MUC17 mucin in specimens of normal, inflamed and neoplastic colon.
  5. pmc DNA methylation and histone H3-K9 modifications contribute to MUC17 expression
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Glycobiology 21:247-56. 2011
    b>MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract. It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs)...
  6. pmc Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity
    Silvia Resta-Lenert
    Department of Medicine, University of California San Diego, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1144-55. 2011
    The membrane-bound mucin MUC17 (mouse homolog Muc3) is highly expressed on the apical surface of intestinal epithelia and is thought to play a role in epithelial restitution and protection...
  7. ncbi Molecular characterization of a major high molecular weight mucin from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Glycobiology 7:965-73. 1997
    ..were hybridized with a series of probes for tandem repeats found in the high molecular weight secreted mucins MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6...
  8. ncbi Two novel mucin genes down-regulated in colorectal cancer identified by differential display
    S J Williams
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cancer Res 59:4083-9. 1999
    ..Both cDNAs were mapped by fluorescence in situ hybridization to chromosome band 7q22, the location of the MUC3 mucin gene, thus suggesting that there may be a cluster of mucin genes at this locus...
  9. ncbi Mucins and mucin binding proteins in colorectal cancer
    James C Byrd
    The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
    Cancer Metastasis Rev 23:77-99. 2004
    ..gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC genes do not fit well into either class (MUC7, MUC8, MUC9, MUC13, MUC15, MUC16)..
  10. ncbi Molecular analysis of colonic transformation in the ileum after total colectomy in rats
    Kouhei Fukushima
    Department of Surgery, Tohoku University, Graduate School of Medicine
    Surgery 140:93-9. 2006
    ..We previously demonstrated roles of aldosterone in enhancement of ileal sodium absorption after TC. However, the significance of aldosterone in intestinal adaptation has been unknown...
  11. ncbi Mucins and mucin-associated carbohydrate antigens expression in gastric carcinoma cell lines
    F Carvalho
    Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, Rua Dr Roberto Frias s n, 4200 Porto, Portugal
    Virchows Arch 435:479-85. 1999
    ..the aberrant pattern of mucin expression observed in human gastric carcinomas with occasional expression of MUC2, MUC3, MUC4 and MUC5B; (c) does not include, at least in our series, the expression of MUC6 mucin; and (d) follows in ..
  12. pmc Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3
    Ismat A Khatri
    Research Institute, Department of Structural Biology and Biochemistry, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Biochem J 378:207-12. 2004
    Rat intestinal mucin Muc3 (rMuc3), like its human homologue (MUC3) and several other membrane mucins, contains a C-terminally located SEA (sea urchin sperm protein, enterokinase and agrin) module, with an intrinsic proteolytic site ..
  13. doi Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet
    Einat Amit-Romach
    Department of Animal Science, The Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    J Nutr Biochem 20:70-7. 2009
    ..area relative to controls; decreased MUC2 mRNA expression in the jejunum, ileum and colon of VAD rats and increased MUC3 mRNA expression in the ileum and colon of these rats...
  14. ncbi Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin
    L G Durrant
    Department of Surgery, University of Nottingham, U K
    Eur J Cancer 30:355-63. 1994
    ..tandem repeat sequences whereas three others, 994/152, 994/91 and 996/36, cross reacted with the MUC2p and the MUC3 tandem repeat peptide but not the MUC1 and MUC4 peptides...
  15. ncbi The MUC3 gene encodes a transmembrane mucin and is alternatively spliced
    S J Williams
    Mater Medical Research Institute, Mater Misericordiae Hospitals, Raymond Terrace, Level 3, Aubigny Place, South Brisbane, Q4101, Australia
    Biochem Biophys Res Commun 261:83-9. 1999
    ..The gene encoding human MUC3 (hMUC3), localised to chromosome 7q22, is most highly expressed in the small intestine...
  16. ncbi Mucin gene expression in gallbladder epithelium with black pigment stone ascertained by in situ hybridization
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 17:517-23. 2001
    ..with black pigment stones (n = 10) and those without stones (n = 6) to identify the expression of MUC1, MUC2, MUC3, MUC4, MUC5B and MUC6 in gallbladder epithelium...
  17. ncbi Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice
    Marie Pierre Buisine
    Unite 560 INSERM, Hopital C Huriez, Lille, France
    Pediatr Res 53:898-904. 2003
    ..tissue sections with 35S-labeled oligonucleotides specific to human tandem repeat sequences for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7...
  18. pmc Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro
    D R Mack
    Department of Pediatrics, University of Ottawa, Canada
    Gut 52:827-33. 2003
    ..Several mucin genes have been described, including MUC3 that is a membrane associated mucin of the small intestine...
  19. ncbi [Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes]
    R M Corrales
    Instituto Universitario de Oftalmobiologia Aplicada IOBA, Universidad de Valladolid, Valladolid, Espana
    Arch Soc Esp Oftalmol 78:375-81. 2003
    ..This study was designed to determine the expression profile of mucin genes in conjunctival impression cytology (CIC) samples from healthy subjects...
  20. ncbi Expression of human mucin genes during normal and abnormal renal development
    Xavier Leroy
    Unit INSERM U560, Department of Pathology, University Hospitals, Lille, France
    Am J Clin Pathol 120:544-50. 2003
    ..MUC1, MUC3, and MUC6 were expressed in normal fetal kidney. MUC1 was expressed from 7...
  21. ncbi [Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition]
    Hyo Jung Kim
    Department of Internal Medicine, Kangwon National University College of Medicine, Chunchon, Korea
    Korean J Gastroenterol 42:330-6. 2003
    ..We compared the expressions of MUC3, MUC5AC, MUC6 and EGFR in the GB epithelium with cholesterol gallstones (GB-chol) group and pigment gallstones (GB-..
  22. ncbi The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins
    Timea Palmai-Pallag
    Paediatric Molecular Genetics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    FEBS J 272:2901-11. 2005
    ..Here we examine the SEA modules of three membrane-tethered mucins, MUC1, MUC3 and MUC12, which have significant sequence homology within the SEA domain...
  23. ncbi Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients
    Jeng Fu You
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine at Linko, Taiwan
    Clin Cancer Res 12:4244-50. 2006
    ..To compare survival and histologic features of hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome) cases to well-matched sporadic colon cancers from the same patient population...
  24. ncbi Mucosal function in rat jejunum and ileum is altered by induction of colitis
    Einat Amit-Romach
    Department of Animal Science, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Int J Mol Med 18:721-7. 2006
    ..The relative amount of MUC2 mRNA decreased in the jejunum, ileum and colon of colitis rat. However, MUC3 mRNA expression increased in the ileum and colon of these rats...
  25. ncbi Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation
    Alexander Vilkin
    Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Petach Tiqwa, Israel
    Dig Dis Sci 52:1613-20. 2007
    ..4 and 100% of gallbladder bile samples, respectively. Immunohistochemistry staining with antibodies to MUC 2, MUC 3, MUC 5AC, MUC 5B and MUC 6 were positive in 0, 100, 85.7, 100 and 95...
  26. pmc Intestinal goblet cells and mucins in health and disease: recent insights and progress
    Young S Kim
    Genemed Biotechnologies, 458 Carlton Court, South San Francisco, CA 94080, USA
    Curr Gastroenterol Rep 12:319-30. 2010
    ..secretory mucin glycoproteins (MUC2) and bioactive molecules such as epithelial membrane-bound mucins (MUC1, MUC3, MUC17), trefoil factor peptides (TFF), resistin-like molecule beta (RELMbeta), and Fc-gamma binding protein (Fcgbp)...
  27. pmc Mucosal barrier in ulcerative colitis and Crohn's disease
    A E Dorofeyev
    National Medical University, Donetsk 83003, Ukraine
    Gastroenterol Res Pract 2013:431231. 2013
    ..Immunohistochemistry was performed using monoclonal mouse antibodies raised against MUC2, MUC3, MUC4, and TFF3 (USBiological, USA). Results. The moderate expression of MUC2 and MUC3 (50.0% and 32.1%, P = 0...
  28. doi Enterotoxigenic Escherichia coli Secretes a Highly Conserved Mucin-Degrading Metalloprotease To Effectively Engage Intestinal Epithelial Cells
    Qingwei Luo
    Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri, USA
    Infect Immun 82:509-21. 2014
    ..that influences intestinal colonization of ETEC by degrading the major mucins in the small intestine, MUC2 and MUC3. Genes encoding YghJ and its cognate type II secretion system (T2SS), which also secretes LT, are highly conserved ..
  29. pmc γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer
    Olivia I Kober
    Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 306:G582-93. 2014
    ..in association with increased gene expression of gel-secreting Muc2 and membrane-bound mucins, including Muc13 and Muc17. Collectively, these data provide evidence that γδ T cells play an important role in the maintenance of mucosal ..
  30. doi Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation
    Ryoko Taguchi
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
    Am J Physiol Cell Physiol 307:C162-8. 2014
    ..3-Oxo-C12-HSL did not induce cell death in differentiated Caco-2 cells that expressed higher levels of mucin 3 (MUC3) than undifferentiated Caco-2 cells...
  31. pmc The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
    Thaher Pelaseyed
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    Immunol Rev 260:8-20. 2014
    ..In addition to the gel-forming mucins, the transmembrane mucins MUC3, MUC12, and MUC17 form the enterocyte glycocalyx that can reach about a micrometer out from the brush border...
  32. doi Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain
    Gabor Cserni
    Bacs Kiskun County Teaching Hospital, Department of Pathology, Kecskemet, Hungary
    Pathology 46:527-32. 2014
    ..one omental metastasis were studied by means of immunohistochemistry, using antibodies to detect EMA, MUC1, MUC2, MUC3, MUC5AC, MUC6, CD10, CA125, carcinoembryonic antigen (CEA)...
  33. doi High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon
    Annaig Lan
    AgroParisTech, Institut National de la Recherche Agronomique INRA, Centre de Recherche en Nutrition Humaine Ile de France, UMR 914 Physiologie de la Nutrition et du Comportement Alimentaire, Paris, France
    J Nutr Biochem 26:91-8. 2015
    ..cells at the epithelial surface but increased goblet cell number in colonic crypts together with an increased Muc3 and a slight reduction of Il-6 gene expression...
  34. doi Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut
    Liesbeth Allais
    Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium
    Environ Microbiol 18:1352-63. 2016
    ..activity in the colon was observed. Also, the mRNA expression of Muc2 and Muc3 increased in the ileum, whereas Muc4 increased in the distal colon of smoke-exposed mice (n = 6)...
  35. doi Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats
    Sung Ho Kook
    Department of Bioactive Material Sciences, Institute of Molecular Biology and Genetics, Institute of Oral Biosciences and School of Dentistry, Chonbuk National University, Jeonju 561 756, South Korea
    Int Immunopharmacol 29:521-7. 2015
    ..This inhibition was accompanied by the increased mRNA levels of mucins MUC2 and MUC3. The CGP treatment prevented phosphorylation of p38 mitogen-activated protein kinase, IκB-α, and DNA-nuclear ..
  36. doi Upregulation of Intestinal Mucin Expression by the Probiotic Bacterium E. coli Nissle 1917
    Mohamed M Hafez
    Department of Microbiology, College of Pharmacy, Taif University, Taif, Western Region, KSA
    Probiotics Antimicrob Proteins 4:67-77. 2012
    ..Incubation of HT-29 cells with EcN lead to a contact time-dependent rise in mRNA levels of the MUC2, MUC3, MUC5AC, and MUC5A. The expression was markedly higher with MUC5AC gene...
  37. doi Semiquantitative immunohistochemistry for mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) profiling of pancreatic ductal cell adenocarcinoma improves diagnostic and prognostic performance
    Marek Sierzega
    First Department of Surgery, Jagiellonian University Medical College, Krakow, Poland
    Histopathology 69:582-91. 2016
    ..The aim of this study was to verify whether semiquantitative evaluation of MUC staining by immunohistochemistry may help to differentiate pancreatic ductal cell adenocarcinoma (PDAC) from chronic pancreatitis and normal pancreas...
  38. doi Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
    Veronika Vymetalkova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, 14200 Prague, Czech Republic
    Carcinogenesis . 2016
    ..65; 95% CI 1.72-4.07; P < 0.0001). In contrast, rectal cancer cases carrying the CC genotype of rs4729655 in MUC17 displayed a longer survival (OS: HR 0.27; 95% CI 0.14-0.54; P = 0.0002) than those with the most common genotype...
  39. ncbi Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O
    Vanessa Lievin-Le Moal
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 510, Pathogénes et Fonctions des Cellules Epithéliales Polarisées, Faculte de Pharmacie Paris XI, F 92296 Chatenay Malabry, France
    Cell Microbiol 4:515-29. 2002
    ..In parallel, analysis of the expression of MUCs genes showed that the transcription of the MUC3, MUC4 and MUC12 genes encoding for membrane-bound mucins was increased in LLO-stimulated cells...
  40. ncbi Epithelial inflammation response induced by Shigella flexneri depends on mucin gene expression
    Sophie Nutten
    Equipe Propre INSERM 0114 sur la Physiopathologie des Maladies Inflammatoires Intestinales, CHU Lille, 59037, Cedex, Lille, France
    Microbes Infect 4:1121-4. 2002
    ..cells, secreting no mucins), HT29-FU (highly expressing MUC2 and MUC4) and HT29-MTX (highly expressing MUC3 and MUC5AC). These cells were infected either by an invasive (M90T) or the control isogenic (BS176) strains of S...
  41. ncbi Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence
    Marilynn A Larson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Biophys Res Commun 300:531-40. 2003
    ..that the N-terminal region of bovine mammary-associated serum amyloid A3 (M-SAA3) increased intestinal mucin MUC3 levels in HT29 human intestinal cells by approximately 2.5-fold, relative to untreated cells...
  42. pmc SEA (sea-urchin sperm protein, enterokinase and agrin)-module cleavage, association of fragments and membrane targeting of rat intestinal mucin Muc3
    Ismat A Khatri
    Research Institute, Department of Structural Biology and Biochemistry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Biochem J 372:263-70. 2003
    ..showed, by transient expression studies in COS-1 cells, that the C-terminal domain of rat intestinal membrane mucin Muc3 was cleaved between glycine and serine within a GSIVV (one-letter) amino acid sequence during its residence in the ..
  43. ncbi [MUC genes: mucin or not mucin? That is the question]
    Nicole Porchet
    Inserm U 560, Place de Verdun, 59045 Lille, France
    Med Sci (Paris) 20:569-74. 2004
    ..mucins or gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6), and membrane-bound mucins (MUC1, MUC3, MUC4, MUC12, MUC17)...
  44. ncbi Immunohistochemical analysis of MUC5B apomucin expression in breast cancer and non-malignant breast tissues
    Cecilia Sóñora
    Departamento de Bioquimica, Laboratorio de Oncología Básica, Universidad de la Republica, Montevideo, Uruguay
    J Histochem Cytochem 54:289-99. 2006
    A deregulation of several MUC genes (MUC1, MUC2, MUC3, MUC5AC, and MUC6) was previously demonstrated in breast carcinomas. Considering that recently we found the "non-mammary" MUC5B mRNA in primary breast tumors (Berois et al...
  45. pmc Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 118:202-15. 2006
    ..Nuclear factor (NF)-kappaB activation, interleukin (IL)-8 secretion, pathogen adherence to IECs, and mucin-3 (MUC3) and E-cadherin gene expression were assayed by TransAM assay, enzyme-linked immunosorbent assay (ELISA), ..
  46. pmc Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
    Jie Huang
    National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
    Blood 120:4873-81. 2012
    ..05). Functional studies identified MUC3 as a candidate gene for the second association signal on 7q22.1...
  47. pmc Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes
    Thaher Pelaseyed
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    Am J Physiol Cell Physiol 305:C457-67. 2013
    We have reported that transmembrane mucin MUC17 binds PDZ protein PDZK1, which retains MUC17 apically in enterocytes. MUC17 and transmembrane mucins MUC3 and MUC12 are suggested to build the enterocyte apical glycocalyx...
  48. ncbi Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22
    M F Fox
    MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London, UK
    Ann Hum Genet 56:281-7. 1992
    The gene MUC3 which codes for a mucin expressed in intestine (Gum et al. 1990) has previously been mapped, using somatic cell hybrids, to chromosome 7...
  49. pmc Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus
    R R Parmley
    Mayo Clinic Scottsdale, Department of Biochemistry and Molecular Biology, Scottsdale, Arizona 85259, USA
    J Clin Invest 102:1798-806. 1998
    ..Analyses of the mucins Muc2, Muc3, and Muc5ac showed lower levels of RNA expression in the CF mice and similar levels of protein...
  50. ncbi Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells
    C M Stanley
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211 7400, USA
    Am J Physiol 277:G191-200. 1999
    Antibodies against MUC2, MUC3, and MUC5AC peptide epitopes stained the secretory contents of all goblet cells in the human colon-derived HT29-18N2 cell line...
  51. ncbi [MUC genes: a superfamily of genes? Towards a functional classification of human apomucins]
    N Porchet
    Unité INSERM n o 377, Lille
    J Soc Biol 193:85-99. 1999
    ..A second group is composed of three independent genes encoding various isoforms of mucins including membrane-bound mucins associated to carcinomas. In this second group, MUC3 and MUC4 encode large apomucins containing EGF-like domains.
  52. ncbi Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study
    F Boman
    Pathology, Calmette Hospital, Lille, France
    J Pathol 193:339-44. 2001
    ..The purpose of this study was to evaluate the expression of mucin genes (MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6) in ovarian mucinous tumour cells, to relate MUC gene expression to the histological ..
  53. ncbi Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease
    K Kyo
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    J Hum Genet 46:5-20. 2001
    ..We reported a possible association of rare variable number of tandem repeat (VNTR) alleles of the "MUC3" gene with a susceptibility to UC...
  54. ncbi Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis
    I A Khatri
    Division of Biochemistry and Structural Biology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Am J Physiol Gastrointest Liver Physiol 280:G1321-30. 2001
    Human mucin MUC3 and rodent Muc3 are widely assumed to represent secretory mucins expressed in columnar and goblet cells of the intestine...
  55. ncbi [Differential mucin expression in the gastrointestinal tract]
    M Cornberg
    Abteilung Gastroenterologie und Hepatologie, Institut für Versuchstierkunde, Medizinische Hochschule Hannover, Hannover, Deutschland
    Z Gastroenterol 39:369-76, 378. 2001
    Under physiological conditions mucins display a tissue specific expression. MUC2, MUC3, MUC5AC and MUC6 are the major mucins in the gastrointestinal tract...
  56. ncbi [Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance]
    R Wang
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Chin Med J (Engl) 113:502-7. 2000
    To explore the clinicopathological significance of the expression of MUC2 (mucin 2) and MUC3 (mucin 3) genes in tissues of the normal gastric mucosa, intestinal metaplasia (IM) and gastric carcinoma.
  57. ncbi Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions
    Benoit Terris
    Services d anatomie pathologique, Hopital Cochin, Paris, France
    J Pathol 197:632-7. 2002
    ..In situ hybridization (ISH) was performed in 28 cases with probes specific for the MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes...
  58. ncbi The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro
    David R Mack
    Department of Pediatrics, Children s Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada
    Pediatr Res 53:137-42. 2003
    ..HT29 cells were grown to enhance expression of either MUC2 or MUC3 intestinal mucins...
  59. ncbi Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia
    Hee Ug Park
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Pancreas 26:e48-54. 2003
    ..Altered levels and patterns of mucin gene expression have been reported to occur in epithelial cancers...
  60. ncbi Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 287:G547-54. 2004
    ..The wild-type mice displayed relatively high levels of Muc1, Muc2, Muc3, and Muc4 mRNAs and relatively low levels of Muc5ac and Muc5b mRNAs in the small intestine...
  61. ncbi MUC3 and MCA serum levels and steroid receptor content in breast cancer
    M Quaranta
    Chemical Clinical Microbiology and Immunology Laboratory Unit, Department of Experimental Oncology, National Oncology Institute, Bari, Italy
    Int J Biol Markers 19:109-14. 2004
    ..The aim of this study was to determine the serum levels of MUC3 and mucin-like carcinoma-associated antigen (MCA) in patients with primary breast cancer and to analyze the ..
  62. ncbi Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6
    Stephane Durual
    INSERM U45, Faculté de Médecine Laennec 7, Rue G Paradin, 69372 Lyon Cedex 08, France
    Differentiation 73:36-44. 2005
    ..The levels of MUC2 and MUC3 mRNA were also increased in the course of the differentiation process...
  63. ncbi Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Gastroenterology 131:210-22. 2006
    ..The gel-forming mucins play an important role in the early stage of cholesterol gallstone formation. We investigated whether the gallbladder epithelial mucin encoded by mucin gene 1 (MUC1) influences susceptibility to gallstones...
  64. ncbi Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 37:1304-15. 2006
    ..and 7 biopsies with high-grade dysplasia [HGD]) were immunostained (ABC method) with antibodies against MUC1, MUC2, MUC3, MUC5AC, and MUC6...
  65. ncbi The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
    C Caballero-Franco
    Institute of Parasitology, McGill University, Saint Anne de Bellevue, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G315-22. 2007
    ..formula, which significantly stimulated colonic mucin (MUC) secretion and MUC2 gene expression; however, MUC1 and MUC3 gene expression were only slightly elevated...
  66. ncbi A new role for cathelicidin in ulcerative colitis in mice
    Emily K K Tai
    Department of Pharmacology, The University of Hong Kong, Hong Kong, China
    Exp Biol Med (Maywood) 232:799-808. 2007
    ..Relative gene expression of mucins (MUC1, MUC2, MUC3, and MUC4) in colonic tissues was determined by real-time polymerase chain reaction...
  67. ncbi MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells
    Julia R Davies
    Mucosal Biology Group, Department of Experimental Medical Science, Lund University, BMC, C13, S 221 84 Lund, Sweden
    Int J Biochem Cell Biol 39:1943-54. 2007
    ..cleavage between these domains, possibly in the SEA domain as demonstrated for other transmembrane mucins; MUC1 and MUC3. After metabolic labeling of NHBE cells, most of the secreted monomeric, high-molecular-mass [(35)S]sulphate-..
  68. ncbi Mucin gene expression in human middle ear epithelium
    Joseph Edward Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1666-76. 2007
    ....
  69. ncbi Oncocytic papillary neoplasms of the biliary tract: a clinicopathological, mucin core and Wnt pathway protein analysis of four cases
    Marjan Rouzbahman
    Department of Pathology, University Health Network University of Toronto, Toronto, Canada
    Pathology 39:413-8. 2007
    ....
  70. pmc Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin
    Rudra Bhowmick
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Infect Immun 76:4968-77. 2008
    ..We found that rGbpA increased the production of intestinal secretory mucins (MUC2, MUC3, and MUC5AC) in HT-29 cells through upregulation of corresponding genes...
  71. doi Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    J Immunol 183:687-95. 2009
    ..the proliferation of HT-29 cells, but significantly increased the mRNA expression of membrane-bound mucins (MUC1, MUC3, and MUC4)...
  72. doi Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain
    Yonghong He
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, People s Republic of China
    Glycobiology 19:1094-102. 2009
    A prominent feature of the rodent Muc3 SEA module is the precursor cleavage event that segregates the O-glycosylated N-terminal fragment and transmembrane domain into the noncovalently attached heterodimer...
  73. doi Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats
    Hiroyuki Ito
    Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Shizuoka 422 8529, Japan
    J Nutr 139:1640-7. 2009
    ..98; P < 0.01). In rats fed the HKM diet, ileal Muc2 gene expression was not affected, but that of Muc3 was lower than in those fed the control diet, indicating that the increase in luminal mucins after ingestion of HKM ..
  74. pmc Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis
    Ying Luu
    Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, United States
    Int J Biochem Cell Biol 42:996-1006. 2010
    The membrane-bound mucins, MUC17 (human) and Muc3 (mouse), are highly expressed on the apical surface of intestinal epithelia and are thought to be cytoprotective...
  75. pmc Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis
    Steven J McElroy
    Dept of Pediatrics, Div of Neonatology, Nashville, TN 37232 0696, USA
    Am J Physiol Gastrointest Liver Physiol 301:G656-66. 2011
    ..TNF-α caused a loss of mucus-containing goblet cells only in immature mice and induced Muc2 and Muc3 mRNA upregulation only in mature ileum...
  76. pmc Cox2 and β-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions
    Jianping Kong
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neoplasia 13:792-805. 2011
    ..More importantly, we observed cysts form within the epithelium, filled with intestinal mucins including Muc5B and Muc17. This suggests that Cox2 expression in a three-dimensional culture environment induces a lineage of mucin-..
  77. doi MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations
    Giulio Rossi
    Section of Pathologic Anatomy, Azienda Ospedaliero Universitaria Policlinico, Via del Pozzo 71, Modena, Italy
    Histopathology 60:1133-43. 2012
    To analyse the expression of several mucins (MUC1, MUC2, MUC3, MUC5AC and MUC6), epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukaemia viral oncogene homologue 2 (HER2), thyroid transcription factor-1 (TTF-1), ..
  78. pmc Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 7:e44108. 2012
    b>MUC17 is a type 1 membrane-bound glycoprotein that is mainly expressed in the digestive tract...
  79. ncbi Dietary supplementation with ovine serum immunoglobulin is associated with an increased gut luminal mucin concentration in the growing rat
    P Balan
    Riddet Institute, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    Animal 5:1916-22. 2011
    ..A similar result was found for crypt goblet cells in the small intestine and colon. Ileal Muc2, Muc3, Muc4 and stomach Muc5Ac mRNA expressions for the FDOI animals were higher (P < 0...
  80. doi Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ
    Chiemi Furuya
    Department of Laboratory Science, Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Pathol Int 62:381-90. 2012
    ..of antibodies, including CK5/6, ER, p63, Ki-67, chromogranin A, synaptophysin, neuron specific enolase, CD56, MUC1, MUC3, CD44, p21, p27, and p53...
  81. ncbi Heterogeneity of mucin gene expression in normal and neoplastic tissues
    S B Ho
    Department of Medicine, University of Minnesota, Minneapolis
    Cancer Res 53:641-51. 1993
    ..and cDNA probes that recognize the core tandem repeat sequences of membrane-bound (MUC1) and secreted (MUC2 and MUC3) mucins were used for immunohistochemical and RNA Northern and slot-blot analysis...
  82. pmc Monoclonal antibodies reacting with the MUC2 mucin core protein
    P L Devine
    Medical Innovations Ltd, Queensland, Australia
    Br J Cancer 67:1182-8. 1993
    ..The MAbs reacted with synthetic MUC2 VNTR peptides but not synthetic MUC1 or MUC3 VNTR peptides, and showed specific reactivity in Western blotting with a high molecular weight protein produced by ..
  83. ncbi Mucin mRNA expression in lung adenocarcinoma cell lines and tissues
    C J Yu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China
    Oncology 53:118-26. 1996
    ..specific antisense oligonucleotide probes recognizing mucin-specific tandem repeats of 4 mucin genes (MUC1, MUC2, MUC3, MUC4)...
  84. ncbi Pattern of mucin gene expression in normal and neoplastic lung tissues
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale Tumori, Milano, Italy
    Anticancer Res 16:2209-13. 1996
    This work evaluates the expression in lung cancer of the most well characterized mucin genes (MUC1, MUC2, MUC3) and of the recently described MUC4 in lung tissues, to check a correlation between the expression of any particular gene and ..
  85. ncbi Mucin genes expressed by human female reproductive tract epithelia
    I K Gipson
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 56:999-1011. 1997
    ..The purpose of this study was to determine whether these cloned mucins, designated MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7, are expressed by epithelia of the female reproductive tract...
  86. ncbi The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs
    I A Khatri
    Division of Research Biochemistry, Research Institute, The Hospital for Sick Children and the University of Toronto, Canada
    Biochim Biophys Acta 1326:7-11. 1997
    ..technique was used to establish the nucleotide sequence encoding the C-terminal 379 amino acids of rat intestinal Muc3. Unlike the C-terminus of Muc2 and many secretory mucins, Muc3 contains two EGF motifs and a putative transmembrane ..
  87. ncbi Structure, function and gene expression of epithelial mucins
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 83:625-32. 1997
    ..immunological and biochemical studies, it is now possible to identify eight apomucin genes, namely MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6 and MUC7...
  88. ncbi Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region
    B J Van Klinken
    Emma Children s Hospital AMC, University of Amsterdam, The Netherlands
    Biochem Biophys Res Commun 238:143-8. 1997
    The human MUC3 gene is highly expressed in small intestine and gallbladder. Thus far only 646 basepairs of its cDNA encoding 17 amino acid repeats have been cloned...
  89. ncbi Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs
    V Debailleul
    Unité INSERM U 377, Laboratoire Gérard Biserte, Place de Verdun, 59045 Lille Cedex, France
    J Biol Chem 273:881-90. 1998
    ..Moreover, allelic variations in length of these mucin transcripts were observed. We demonstrate that these variations are directly related to the variable number of tandem repeat polymorphisms seen at the DNA level...
  90. pmc Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains
    L L Shekels
    Department of Medicine, University of Minnesota and VA Medical Center, Minneapolis, MN 55417, USA
    Biochem J 330:1301-8. 1998
    ..this gene to mouse chromosome 5 in a region of conserved linkage with human chromosome 7, the location of the human MUC3 gene. We conclude that we have identified a mouse caecal mucin which represents the mouse homologue of human MUC3...
  91. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
    ..amounts of total biliary mucins, the affected ducts showed an increase in mRNA levels of CFTR as well as MUC2, MUC3, MUC5AC, MUC5B, and MUC6 compared with the ducts from control subjects...
  92. ncbi Inflammatory bowel disease: progress toward a gene
    D A van Heel
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Can J Gastroenterol 14:207-18. 2000
    ..Other important candidate genes investigated include the interleukin-1 receptor antagonist, MUC3 and genes of the human leukocyte antigen (HLA) system...
  93. ncbi Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B
    W S Pratt
    MRC Human Biochemical Genetics Unit, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom
    Biochem Biophys Res Commun 275:916-23. 2000
    The MUC3 gene encodes a transmembrane mucin-type glycoprotein...
  94. pmc Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study
    G S Arul
    Department of Paediatric Surgery, Bristol Royal Infirmary, Bristol, UK
    Gut 47:753-61. 2000
    ..Little is known about the expression pattern in the oesophagus. In this study we have investigated MUC gene expression in both the normal oesophagus and specialised intestinal metaplasia (Barrett's oesophagus)...
  95. ncbi Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas
    M P Buisine
    Laboratoire de Biochimie et de Biologie Moleculaire, Hopital C Huriez, CHRU, Lille, France
    J Histochem Cytochem 48:1667-76. 2000
    ..in fetal duodenum reiterated the patterns we observed during gastric and intestinal ontogenesis, with MUC2 and MUC3 expression in the surface epithelium and MUC6 expression associated with the development of Brünner's glands...
  96. ncbi Identification of MUC1 proteolytic cleavage sites in vivo
    S Parry
    Paediatric Molecular Genetics, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Biochem Biophys Res Commun 283:715-20. 2001
    ..The identification of several membrane-tethered mucins, including MUC1, MUC3, MUC4, and MUC12, has incited interest in the processing of these mucins and the mechanisms that govern their ..
  97. pmc Mucin gene expression in intestinal epithelial cells in Crohn's disease
    M P Buisine
    Unité Inserm no 377, Lille, France
    Gut 49:544-51. 2001
    ..Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease of unknown origin. It is characterised by chronic mucosal ulcerations which affect any part of the intestine but most commonly are found in the ileum and proximal colon...
  98. ncbi Pattern changes of mucin gene expression with pneumococcal otitis media
    Y Tsuboi
    Otitis Media Research Center, Department of Otolaryngology, School of Medicine, University of Minnesota, 2001 Sixth Street S E, Rm 216, Minneapolis, MN 55455, USA
    Int J Pediatr Otorhinolaryngol 61:23-30. 2001
    ..The purpose of this study was to characterize mucin gene expression in middle ears and Eustachian tubes with pneumococcal ear infection...
  99. ncbi Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genes
    M C Copin
    Laboratoire de Biochimie et Biologie Moleculaire, Hopital C Huriez CHRU Lille, France, Faculte de Medecine, Universite de Lille II, Lille, France
    Front Biosci 6:D1264-75. 2001
    ..5 and encode secretory gel forming mucins while MUC1, MUC3, MUC4, MUC7 are scattered on different chromosomes and encode membrane-bound or secreted mucins...
  100. ncbi Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dig Dis Sci 46:2166-72. 2001
    ..intrahepatic bile ducts, cholangiocarcinomas, and normal controls to identify the expression of MUC2, MUC3, MUC4, MUC5B, and MUC5AC in nonneoplastic and neoplastic biliary epithelium...
  101. pmc Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia
    P A Sylvester
    Department of Surgery, Bristol Royal Infirmary, Bristol, UK
    Gut 51:386-91. 2002
    ..Mucin gene expression is altered in colorectal neoplasia and inflammatory bowel disease but little is known of its expression in the IAR...

Research Grants13

  1. Michael A Hollingsworth; Fiscal Year: 2015
    ..The earliest premalignant and malignant lesions in the pancreas express MUCI, MUC4, MUC5ac, MUC16, and MUC17 with truncated O-linked structures attached (Tn, sialyl Tn, T) but may not produce a sufficient amount to be ..
  2. Production of human MUC17 (CRD1-L-CRD2) recombinant protein in rice for the treat
    Ning Huang; Fiscal Year: 2013
    ..applicant): Recent studies in animal models demonstrate that an endogenous human intestinal mucin fragment, termed MUC17, augments intestinal cell restitution and enhances healing of experimental colitis, potentially opening a new door ..
  3. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
    ..Human gallbladder expresses genes for five different mucins and two of these, MUC5B and MUC3 have been identified as the major human gallbladder mucins...
  4. GLYCOCONJUGATES IN PANCREATIC CANCER
    Young Kim; Fiscal Year: 2002
    ..They have also determined that MUC3 is an important component of pancreatic cancer mucin and made significant strides towards obtaining the complete ..
  5. Novel Proteins for Treatment of Bowel Diseases
    ROBERT HEINRIKSON; Fiscal Year: 2005
    ..These variants, together with the EFD units of human mucins MUC3 and MUC17, will be incorporated by cassette mutagenesis into the mucin structural format...
  6. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  7. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  8. MUCIN SECRETION IN COLUMNAR EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..The sponsor's group's expertise in biliary cell biology will ensure a supportive and stimulating environment for the candidate. ..
  9. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  10. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ....
  11. Mucin expression in rheumatoid arthritis
    MICHAEL VOLIN; Fiscal Year: 2008
    ..Preliminary data examining the expression of mucins in RA and osteoarthritis (OA) indicate that: 1) MUC3 and MUC5AC expression is upregulated in arthritic synovial tissue over normal synovial tissue; 2) synovial ..
  12. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..abstract_text> ..