MUC1

Summary

Gene Symbol: MUC1
Description: mucin 1, cell surface associated
Alias: ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin-1, H23 antigen, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, episialin, krebs von den Lungen-6, mucin 1, transmembrane, peanut-reactive urinary mucin, polymorphic epithelial mucin, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen
Species: human

Top Publications

  1. ncbi Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding
    Amantha Thathiah
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Biol Chem 278:3386-94. 2003
  2. pmc MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling
    Rehan Ahmad
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 9:1419-27. 2007
  3. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
  4. pmc A minimal fragment of MUC1 mediates growth of cancer cells
    Sanjeev Mahanta
    Minerva Biotechnologies, Waltham, Massachusetts, United States of America
    PLoS ONE 3:e2054. 2008
  5. ncbi Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism
    Qian Xu
    Cancer Control Laboratory of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, P R China
    Int J Oncol 35:1313-20. 2009
  6. ncbi A human cytotoxic T-lymphocyte epitope and its agonist epitope from the nonvariable number of tandem repeat sequence of MUC-1
    Kwong Yok Tsang
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:2139-49. 2004
  7. doi Evaluation of a novel anti-mucin 1 (MUC1) antibody (PankoMab) as a potential diagnostic tool in human ductal breast cancer; comparison with two established antibodies
    Darius Dian
    Department of Obstetrics and Gynecology, Ludwig Maximilians Universitat Munchen, Frauenklinik, Maistrasse 11, Munich, Germany
    Onkologie 32:238-44. 2009
  8. pmc MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop
    Rehan Ahmad
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 4:ra9. 2011
  9. pmc Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier
    PABLO ARGUESO
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 284:23037-45. 2009
  10. ncbi Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese
    Fang Li
    Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Asian Pac J Cancer Prev 13:2593-6. 2012

Research Grants

  1. Jia Luo; Fiscal Year: 2016
  2. Venu Raman; Fiscal Year: 2015
  3. Anna Moore; Fiscal Year: 2016
  4. Matthew B Renfrow; Fiscal Year: 2016
  5. Studies on the Post-translational processing of MUC1
    Michael A Hollingsworth; Fiscal Year: 2012
  6. RODNEY JON SCHLOSSER; Fiscal Year: 2014
  7. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
  8. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010
  9. Jeffrey S Souris; Fiscal Year: 2016
  10. Pi Wan Cheng; Fiscal Year: 2015

Detail Information

Publications347 found, 100 shown here

  1. ncbi Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding
    Amantha Thathiah
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Biol Chem 278:3386-94. 2003
    b>MUC1 clearance from the uterine epithelial cell surface is a prerequisite for the creation of an environment conducive to embryo implantation...
  2. pmc MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling
    Rehan Ahmad
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 9:1419-27. 2007
    ..The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-kappaB, blocks apoptosis and ..
  3. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
    ..This miR-145-mediated suppression of cell invasion is in part due to the silencing of the metastasis gene mucin 1 (MUC1)...
  4. pmc A minimal fragment of MUC1 mediates growth of cancer cells
    Sanjeev Mahanta
    Minerva Biotechnologies, Waltham, Massachusetts, United States of America
    PLoS ONE 3:e2054. 2008
    The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells...
  5. ncbi Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism
    Qian Xu
    Cancer Control Laboratory of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, P R China
    Int J Oncol 35:1313-20. 2009
    Identifying the genetic variants that alter MUC1 protein expression may further our understanding of the risk for development of gastric cancer (GC)...
  6. ncbi A human cytotoxic T-lymphocyte epitope and its agonist epitope from the nonvariable number of tandem repeat sequence of MUC-1
    Kwong Yok Tsang
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:2139-49. 2004
    ....
  7. doi Evaluation of a novel anti-mucin 1 (MUC1) antibody (PankoMab) as a potential diagnostic tool in human ductal breast cancer; comparison with two established antibodies
    Darius Dian
    Department of Obstetrics and Gynecology, Ludwig Maximilians Universitat Munchen, Frauenklinik, Maistrasse 11, Munich, Germany
    Onkologie 32:238-44. 2009
    PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1)...
  8. pmc MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop
    Rehan Ahmad
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 4:ra9. 2011
    ..b>Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas and, like STAT3, ..
  9. pmc Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier
    PABLO ARGUESO
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 284:23037-45. 2009
    ..of the eye as a model system, we found that galectin-3 colocalized with two distinct membrane-associated mucins, MUC1 and MUC16, on the apical surface of epithelial cells and that both mucins bound to galectin-3 affinity columns in a ..
  10. ncbi Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese
    Fang Li
    Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Asian Pac J Cancer Prev 13:2593-6. 2012
    A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigate whether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastric cancer in a Chinese population.
  11. doi Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels
    Yasushi Horimasu
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Respir Med 106:1756-64. 2012
    KL-6 is a high-molecular-weight glycoprotein classified as human Mucin-1 (MUC1). KL-6 has been reported to be a sensitive biomarker for interstitial lung diseases (ILDs) in the Japanese population...
  12. pmc The human endometrium expresses the glycoprotein mucin-1 and shows positive correlation for Thomsen-Friedenreich epitope expression and galectin-1 binding
    Udo Jeschke
    1st Department of Obstetrics and Gynaecology, Ludwig Maximilians University Munich, Maistrasse 11, 80337 Munich, Germany
    J Histochem Cytochem 57:871-81. 2009
    b>Mucin 1 (MUC1) is a glycoprotein in human endometrium and is abundant at the luminal epithelial surface in the receptive phase...
  13. ncbi Expression of mucin-1, galectin-1 and galectin-3 in human leiomyosarcoma in comparison to leiomyoma and myometrium
    Tobias Weissenbacher
    Department of Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Maistrasse 11, 80337 Munich, Germany
    Anticancer Res 31:451-7. 2011
    ..The aim was the evaluation of expression patterns of mucin-1 (MUC1) (MUC1 VU-4-H5), galectin-1 (Gal-1) and galectin-3 (Gal-3) in human myometrium and leiomyoma and in comparison to ..
  14. doi Potential application of alternatively glycosylated serum MUC1 and MUC5AC in gastric cancer diagnosis
    Ye Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, No 320 Yueyang Road, Shanghai 20031, China
    Biologicals 37:18-25. 2009
    ..enzyme immunoassays were utilized to explore the clinical diagnostic value of the alternatively glycosylated MUC1 and MUC5AC. Four pairs of antibodies were selected to construct quantitative sandwich enzyme immunoassay...
  15. pmc Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis
    Yasunari Kawabata
    Department of Digestive and General Surgery, Shimane University Faculty of Medicine, 89 1 Enyacho, Izumo, Shimane 693 8501, Japan
    Diagn Pathol 5:75. 2010
    ..We assessed the expression of cytokeratin (CK) and apomucin (MUC) in ampullary carcinoma (AC) to develop a system for the classification of ACs on the basis of their clinical significance...
  16. ncbi MUC1 is a novel regulator of ErbB1 receptor trafficking
    M R Pochampalli
    Department of Molecular and Cellular Biology, Arizona Cancer Center and Bio5 Institute, University of Arizona, Tucson, AZ 85724, USA
    Oncogene 26:1693-701. 2007
    ..The oncogenic glycoprotein MUC1 is a binding partner and substrate for erbB1 and MUC1 expression can potentiate erbB-dependent signal transduction...
  17. pmc MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion
    Jingchun Gao
    Department of Thoracic Oncology and Experimental Therapeutics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Oncol 35:337-45. 2009
    ..One putative downstream gene regulated by Stat3 is MUC1 which also has important roles in tumorigenesis...
  18. pmc MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
    Sean P Pitroda
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:5837-41. 2009
    The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in human breast cancers...
  19. doi MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells
    E Lacunza
    Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Universidad Nacional de La Plata, Argentina
    Cancer Genet Cytogenet 201:102-10. 2010
    The MUC1 gene is aberrantly overexpressed in approximately 90% of human breast cancers. Several studies have shown that MUC1 overexpression is due to transcriptional regulatory events...
  20. ncbi Developmental expression of mucin genes MUC1 and MUC2
    J A Chambers
    Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, UK
    J Cell Sci 107:413-24. 1994
    The mucin gene MUC1, is expressed in a number of human ductal epithelia in vivo including those within the pancreas, mammary gland, kidney and genital ducts...
  21. ncbi MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer
    M Quaranta
    Department of Experimental Oncology, Laboratory of Analyses, Institute of Oncology, Bari, Italy
    Anticancer Res 27:3593-600. 2007
    ..Owing to their matrix-degrading abilities and high expression in advanced tumours, MMPs were originally implicated in cancer progression, invasion and metastasis...
  22. pmc Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-γ
    Yong Sung Park
    Department of Physiology and Lung Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 303:G765-74. 2012
    b>MUC1 is a membrane-tethered mucin expressed on the apical surface of epithelial cells. Our previous report (Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP...
  23. pmc MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells
    Dina Stroopinsky
    Beth Israel Deaconess Medical Center and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 73:5569-79. 2013
    Acute myeloid leukemia (AML) is a malignancy of stem cells with an unlimited capacity for self-renewal. MUC1 is a secreted, oncogenic mucin that is expressed aberrantly in AML blasts, but its potential uses to target AML stem cells have ..
  24. pmc MUC1: a novel metabolic master regulator
    Kamiya Mehla
    The Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochim Biophys Acta 1845:126-35. 2014
    b>MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin...
  25. ncbi Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
    Sandra Guaita
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, E 08003 Barcelona, Spain
    J Biol Chem 277:39209-16. 2002
    ..Other epithelial markers like Cytokeratin 18 or MUC1 were also repressed...
  26. ncbi The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice
    Mara Gerloni
    Laboratory of Immunology, Department of Medicine and Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 175:6551-9. 2005
    ..1 lacked cytolytic function, but produced IFN-gamma upon restimulation with Ag. We conclude that immunity against tumor self-Ags and tumor protection can be regulated exploiting an inherent property of the immune system...
  27. ncbi Expression of aberrantly glycosylated tumor mucin-1 on human DC after transduction with a fiber-modified adenoviral vector
    E B M van Leeuwen
    Department of Internal Medicine, Division of Hemato Oncology, University Hospital Maastricht, Maastricht, The Netherlands
    Cytotherapy 8:24-35. 2006
    ..DC-presenting tumor Ag are currently being developed to be used as a vaccine in human cancer immunotherapy. To increase chances for successful therapy it is important to deliver full-length tumor Ag instead of loading single peptides...
  28. pmc Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion
    Ashlyn J Bernier
    Department of Laboratory Medicine and Pathology, 3 70 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Mol Cancer 10:93. 2011
    The mucin MUC1, a type I transmembrane glycoprotein, is overexpressed in breast cancer and has been correlated with increased metastasis...
  29. doi Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1
    Christoph Scholz
    Department of Obstetrics and Gynecology, Medical Faculty, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Arch Gynecol Obstet 285:605-12. 2012
    ..Putative accompanying markers of trophoblastic damage were also explored...
  30. doi MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via β1-integrin signaling
    Ming Kwang Shyu
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, Taiwan
    J Clin Endocrinol Metab 96:3759-67. 2011
    ..We have previously shown that MUC1 expression in human placenta increases with gestational age and inhibits choriocarcinoma cell invasion.
  31. doi MUC1 in mesenchymal-to-epithelial transition during human nephrogenesis: changing the fate of renal progenitor/stem cells?
    Daniela Fanni
    Department of Pathology, University of Cagliari, Cagliari, Italy
    J Matern Fetal Neonatal Med 24:63-6. 2011
    ..Few immunohistochemical markers are available for detecting cap mesenchymal cells in the early phases of MET...
  32. doi Specific decidual CD14(+) cells hamper cognate NK cell proliferation and cytolytic mediator expression after mucin 1 treatment in vitro
    Gordana Laskarin
    Department of Physiology and Immunology, University of Rijeka, 51000 Rijeka, B Branchetta 20, Croatia
    J Reprod Immunol 95:36-45. 2012
    b>Mucin 1 (MUC1) forms a glycocalyx on the surface of decidual epithelial cells that needs to be removed for successful embryo attachment...
  33. ncbi Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 40:198-202. 2007
    To clarify the localization of KL-6 and epithelial membrane antigen (EMA) in human lungs, immune reactions to antibodies to these factors were examined in detail at light and electron microscopic levels...
  34. ncbi MUC-1 (CA 15-3 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients
    A Bearz
    Division of Medical Oncology A, National Cancer Institute, Aviano, Pordenone, Italy
    Int J Biol Markers 22:307-11. 2007
    ..No tumor marker has been validated in the diagnosis and follow-up of lung cancer, in particular to predict the outcome of treatment with EGFR inhibitors...
  35. doi MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13
    Qing Ye
    Department of Cardiothoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Lab Invest 91:778-87. 2011
    ..Given the associations of MUC1 with ESCC and tumor metastasis, we explored a potential role of MUC1 in ESCC metastasis...
  36. ncbi The lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 is involved in O-glycosylation of a polypeptide with multiple acceptor sites
    Mari Tenno
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kita ku, Kyoto 603 8555, Japan
    J Biol Chem 277:47088-96. 2002
    ..This suggests a cooperative involvement of each repeat unit in the glycosylation of polypeptides with multiple acceptor sites...
  37. ncbi MUC 1 mucin content in gastric juice of duodenal ulcer patients: effect of Helicobacter pylori eradication therapy
    I Radziejewska
    Department of Medical Chemistry, Medical University of Białystok, ul Mickiewicza 2A, 15 089, Białystok 8, Poland
    Clin Exp Med 7:72-6. 2007
    ..Also the epithelial MUC 1 mucin is implicated by some authors to have a major role in the mechanism of infection...
  38. ncbi High level of MUC1 in serum of ovarian and breast cancer patients inhibits huHMFG-1 dependent cell-mediated cytotoxicity (ADCC)
    Maria Moreno
    Department of Obstetrics and Gynaecology, VU Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cancer Lett 257:47-55. 2007
    The huHMFG-1 (AS1402) antibody is a humanised IgG1 directed against MUC1 and is currently in clinical trials for the treatment of breast carcinoma...
  39. doi Loss of ICAM-1 signaling induces psoriasin (S100A7) and MUC1 in mammary epithelial cells
    S Petersson
    Department of Clinical Genetics, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Breast Cancer Res Treat 125:13-25. 2011
    ..correlation between the expression of ICAM-1 and psoriasin, and a positive correlation between psoriasin and MUC1 in normal and DCIS SAGE libraries...
  40. pmc MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling
    Jian Ren
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cancer Res 4:873-83. 2006
    ..The MUC1 oncoprotein is aberrantly overexpressed by certain hematologic malignancies and most human carcinomas...
  41. ncbi MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress
    Li Yin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:45721-7. 2004
    The MUC1 transforming protein is aberrantly overexpressed by most human carcinomas...
  42. ncbi The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)
    Y Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 281:440-3. 2001
    The human DF3/MUC1 glycoprotein is aberrantly overexpressed by carcinoma cells. The present studies show that MUC1 associates with the Armadillo protein, p120(ctn). The cytoplasmic domain of MUC1 binds directly to p120...
  43. ncbi Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
    Li Yin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:35458-64. 2003
    The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed by most human carcinomas...
  44. doi MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:2708-16. 2008
    b>MUC1 is a transmembrane mucin that is highly expressed in various cancers and correlates with malignant potential...
  45. ncbi DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7
    Yongqing Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 2:187-93. 2003
    The human DF3/MUC1 transmembrane protein is aberrantly expressed in multiple myeloma cells and other B cell malignancies. The regulation of MUC1 in B cells and its potential function as a signaling molecule are unknown...
  46. pmc Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components
    J Wesseling
    Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam
    J Cell Biol 129:255-65. 1995
    b>Episialin (MUC1) is a transmembrane molecule with a large mucin-like extracellular domain protruding high above the cell surface...
  47. ncbi Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions
    J Fernandez-Rodriguez
    Department of Medical Biochemistry, Goteborg University, Box 440, 405 30 Gothenburg, Sweden
    Glycoconj J 18:925-30. 2001
    The mucins secreted from the colon carcinoma cell line COLO 205 have the MUC1 and CD43 (leukosialin) as core proteins, where both carry sialyl-Lewis a and MUC1 sialyl-Lewis x epitopes...
  48. pmc MUC1 alters oncogenic events and transcription in human breast cancer cells
    Christine L Hattrup
    Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Breast Cancer Res 8:R37. 2006
    b>MUC1 is an oncoprotein whose overexpression correlates with aggressiveness of tumors and poor survival of cancer patients...
  49. ncbi Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion
    M Yamamoto
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:12492-4. 1997
    The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin...
  50. ncbi Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue
    S Zrihan-Licht
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Eur J Biochem 224:787-95. 1994
    The human breast cancer marker protein, MUC1, is a polymorphic transmembrane molecule containing a large extracellular domain that is primarily composed of a variable number of highly conserved 20-amino-acid tandem repeats...
  51. ncbi Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies
    N Smorodinsky
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Biochem Biophys Res Commun 228:115-21. 1996
    Although MUC1 proteins are known to be secreted by breast cancer cells, the mechanism of their release from the cell is still obscure...
  52. ncbi Identification of MUC1 proteolytic cleavage sites in vivo
    S Parry
    Paediatric Molecular Genetics, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Biochem Biophys Res Commun 283:715-20. 2001
    ..The identification of several membrane-tethered mucins, including MUC1, MUC3, MUC4, and MUC12, has incited interest in the processing of these mucins and the mechanisms that govern their ..
  53. ncbi MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells
    M Wykes
    Dendritic Cell, Mater Medical Research Institute, Mater Misericordiae Hospitals, South Brisbane, Australia
    J Leukoc Biol 72:692-701. 2002
    The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation...
  54. ncbi Tissue and serum MUC1 mucin detection in breast cancer patients
    María V Croce
    Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Facultad de Ciencias Medicas, UNLP La Plata, Argentina
    Breast Cancer Res Treat 81:195-207. 2003
    Tumor MUC1 expression as well as levels of MUC1, MUC1 circulating immune complexes (MUC1-CIC) and free antibodies against MUC1 (IgG and IgM-MUC1) were evaluated in 70 breast cancer patients with different stages of disease...
  55. ncbi MZF-1 and DbpA interact with DNase I hypersensitive sites that correlate with expression of the human MUC1 mucin gene
    Toshiyuki Shiraga
    Paediatric Molecular Genetics, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Exp Cell Res 308:41-52. 2005
    The MUC1 mucin is a large membrane-tethered glycoprotein that shows differential expression in many adenocarcinomas, where it contributes to their invasive and metastatic properties...
  56. pmc Short mucin 1 alleles are associated with low virulent H pylori strains infection
    Barbara Peleteiro
    World J Gastroenterol 13:1885-6. 2007
  57. pmc Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells
    Susan Fanayan
    Molecular Oncology Laboratory, Oncology Research Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, 2145 NSW, Australia
    BMC Cell Biol 10:7. 2009
    ..MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners...
  58. pmc Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3
    M Artico
    Department of Otorhinolaringology, Audiology and Phoniatry G Ferreri, University of Rome La Sapienza, Rome, Italy
    Eur J Histochem 54:e10. 2010
    ....
  59. ncbi Cell-associated episialin is a complex containing two proteins derived from a common precursor
    M J Ligtenberg
    Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam
    J Biol Chem 267:6171-7. 1992
    cDNA for the epithelial sialomucin episialin encodes a transmembrane molecule with a large extracellular domain, which mainly consists of repeats of 20 amino acids...
  60. ncbi A transcribed gene, containing a variable number of tandem repeats, codes for a human epithelial tumor antigen. cDNA cloning, expression of the transfected gene and over-expression in breast cancer tissue
    M Hareuveni
    Department of Microbiology, Faculty of Life Sciences, Tel Aviv University, Israel
    Eur J Biochem 189:475-86. 1990
    ..The above studies unequivocally establish the over-expression of a VNTR gene coding for an epithelial tumor antigen in human breast cancer tissue...
  61. ncbi Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit
    C A Lancaster
    Imperial Cancer Research Fund, London, U K
    Biochem Biophys Res Commun 173:1019-29. 1990
    The human polymorphic epithelial mucin (PEM) is expressed apically by glandular epithelium and by the carcinomas that develop from these tissues...
  62. ncbi Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
    D Kufe
    Hybridoma 3:223-32. 1984
    ..These results demonstrate that the DF3 antigen is present on apical borders of more differentiated secretory mammary epithelial cells and in the cytosol of less differentiated cells...
  63. ncbi Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene
    M Weiss
    The E Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Int J Cancer 66:55-9. 1996
    ..We have recently described a marked over-expression of the MUC1 gene in thyroid papillary-carcinoma tissue, as compared with various benign thyroid pathologies...
  64. pmc Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin
    D Nath
    ICRF Laboratories, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
    Immunology 98:213-9. 1999
    ..Following precipitation with Sn-Fc, a major band of approximately 240000 MW was revealed, which was shown in reprecipitation and Western blotting experiments to be the epithelial mucin, MUC1.
  65. ncbi Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism
    Baldev Vasir
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:2376-86. 2005
    The MUC1 transmembrane mucin is expressed on the surface of activated human T cells; however, the physiologic signals responsible for the regulation of MUC1 in T cells are not known...
  66. ncbi Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice
    Wenju Lu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201, USA
    J Immunol 176:3890-4. 2006
    b>MUC1 (MUC1 in human and Muc1 in nonhumans) is a membrane-tethered mucin that interacts with Pseudomonas aeruginosa (PA) through flagellin...
  67. pmc MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Deepak Raina
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    EMBO J 25:3774-83. 2006
    ..The MUC1 oncoprotein is overexpressed by most human carcinomas and blocks the induction of apoptosis by genotoxic agents...
  68. ncbi Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat
    Mads A Tarp
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen N, Denmark
    Glycobiology 17:197-209. 2007
    The cell membrane mucin MUC1 is over-expressed and aberrantly glycosylated in many cancers, and cancer-associated MUC1 glycoforms represent potential targets for immunodiagnostic and therapeutic measures...
  69. ncbi Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62
    Yumei Leng
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:19321-30. 2007
    The MUC1 heterodimeric transmembrane protein is aberrantly overexpressed by most human carcinomas...
  70. ncbi Down-regulation of MUC1 in cancer cells inhibits cell migration by promoting E-cadherin/catenin complex formation
    Zhenglong Yuan
    Department of Surgery, Rhode Island Hospital, Brown University, 2 Dudley Street, Suite 470, Providence, RI 02905, USA
    Biochem Biophys Res Commun 362:740-6. 2007
    b>MUC1, a tumor associated glycoprotein, is over-expressed in most cancers and can promote proliferation and metastasis. The objective of this research was to study the role of MUC1 in cancer metastasis and its potential mechanism...
  71. pmc MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8
    Naoki Agata
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:6136-44. 2008
    ..The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis...
  72. doi Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1)
    Carlo Patriarca
    Department of Pathology, Azienda Ospedaliera di Melegnano, and University of Milan Medical School, ICH Humanitas Rozzano, Milan, Italy
    Int J Surg Pathol 17:99-106. 2009
    ..Ep-CAM was present in all the cases with a heterogeneous staining pattern. Similarly, MUC1/episialin was variously present in 94% of the cases without a polarized staining pattern and was expressed more strongly ..
  73. doi MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression
    Sebastien Aubert
    Institut National de Santé et de Recherche Médicale, U837, Jean Pierre Aubert Research Center, Lille, France
    Cancer Res 69:5707-15. 2009
    The hypoxia inducible factor (HIF) signaling pathway is known as the main renal carcinogenetic pathway. MUC1, an O-glycoprotein membrane-bound mucin, is overexpressed in clear renal cell carcinomas (cRCC) with correlation to two major ..
  74. ncbi Functional targeting of the MUC1 oncogene in human cancers.
    Donald W Kufe
    Cancer Biol Ther 8:1197-203. 2009
  75. pmc Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface
    Qicheng Zhao
    Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Cancer Res 69:6799-806. 2009
    ..These effects of galectin-3 are shown to be a consequence of its interaction with cancer-associated MUC1, which breaks the "protective shield" of the cell-surface MUC1 by causing MUC1 polarization, leading to exposure of ..
  76. pmc MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Pathog 5:e1000617. 2009
    ..The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H...
  77. pmc The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF
    M E Behrens
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Oncogene 29:5667-77. 2010
    The MUC1 cytoplasmic tail (MUC1.CT) conducts signals from spatial and extracellular cues (growth factor and cytokine stimulation) to evoke a reprogramming of the cellular transcriptional profile. Specific phosphorylated forms of the MUC1...
  78. doi Expression of aberrantly glycosylated Mucin-1 in ovarian cancer
    Catharina H M J Van Elssen
    Department of Internal Medicine, Division of Haematology, Maastricht University Medical Center, Maastricht, The Netherlands
    Histopathology 57:597-606. 2010
    b>Mucin 1 (MUC1) is an important tumour-associated antigen (TAA), both overexpressed and aberrantly glycosylated in adenocarcinomas...
  79. doi Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome
    Rosa M Corrales
    Networking Biomedical Research Center in Biomaterials, Bioengineering, and Nanomedicine in Valladolid CIBER BBN, Carlos III Health Institute, Ministry of Science and Innovation, Valladolid, Spain
    Invest Ophthalmol Vis Sci 52:8363-9. 2011
    To evaluate mRNA levels of the ocular mucins MUC1, MUC2, MUC4, MUC5AC, and MUC7 in conjunctival impression cytology samples from patients with moderate to severe dry eye syndrome (DES) compared with a population of healthy subjects; and ..
  80. pmc MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis
    Yuichiro Suzuki
    Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Int J Oncol 40:1831-8. 2012
    ..of C2GnT in bladder tumors positively correlates with tumor progression and that bladder tumor cell-surface mucin 1 (MUC1) carrying core 2 O-glycans plays an important role in the evasion from natural killer (NK) cell attack...
  81. doi Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls
    Leizhen Zheng
    Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China
    Mol Biol Rep 40:5791-6. 2013
    ..This variant was associated with altered physiological function of MUC1 possibly by modulating promoter activity and alternative splicing of MUC1...
  82. ncbi Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin
    S J Gendler
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    J Biol Chem 265:15286-93. 1990
    Human mammary cells present on the cell surface a polymorphic epithelial mucin (PEM) which is developmentally regulated and aberrantly expressed in tumors...
  83. ncbi Mucin mRNA expression in lung adenocarcinoma cell lines and tissues
    C J Yu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China
    Oncology 53:118-26. 1996
    ..with specific antisense oligonucleotide probes recognizing mucin-specific tandem repeats of 4 mucin genes (MUC1, MUC2, MUC3, MUC4)...
  84. ncbi Mucin genes expressed by human female reproductive tract epithelia
    I K Gipson
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 56:999-1011. 1997
    ..The purpose of this study was to determine whether these cloned mucins, designated MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7, are expressed by epithelia of the female reproductive tract...
  85. ncbi Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form (MUC-1/Z)
    H M Oosterkamp
    Gynecology Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 72:87-94. 1997
    ..The possible role of MUC-1/Y and MUC-1/Z variant forms in these cell lines is not understood...
  86. ncbi The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein
    A Baruch
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Cancer Res 59:1552-61. 1999
    b>MUC1 proteins, some of which contain a mucin-like domain and others lacking this region, can be generated from the human breast cancer-associated MUC1 gene by alternative splicing...
  87. ncbi Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland
    J A Schroeder
    Mayo Clinic Scottsdale, S C Johnson Research Building, Scottsdale, Arizona 85259, USA
    J Biol Chem 276:13057-64. 2001
    b>MUC1 is a large (>400 kDa), heavily glycosylated transmembrane protein that is aberrantly expressed on greater than 90% of human breast carcinomas and subsequent metastases...
  88. ncbi Distribution of MUC1 in the normal human oral cavity is localized to the ducts of minor salivary glands
    A Sengupta
    Department of Anatomy, School of Veterinary Science, Southwell Street, BS2 8HW, Bristol, UK
    Arch Oral Biol 46:529-38. 2001
    The change in expression of MUC1 from health to disease forms the basis of its use as a potential disease marker...
  89. pmc Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins
    Daniel H Wreschner
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    Protein Sci 11:698-706. 2002
    ..It could well lead to the rational design and identification of molecules that, by binding to one of the cleaved partners, will act either as agonists or antagonists, alter signal transduction and, hence, cellular behavior...
  90. ncbi Expression of MUCI splice variants correlates with invasive growth of breast cancer cell lines
    Bernd C Schmid
    Molecular Oncology Group, Division of Gynecology, Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria
    Breast Cancer Res Treat 76:211-9. 2002
    ..These findings suggest that the invasive behavior of breast cell lines may depend on different expression patterns of the MUCI gene determined by a genetic polymorphism...
  91. pmc Human DF3/MUC1 carcinoma-associated protein functions as an oncogene
    Yongqing Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 22:6107-10. 2003
    The human DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed by most carcinomas of the breast and other epithelia. The contribution of MUC1 overexpression to the malignant phenotype is, however, not known...
  92. ncbi MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation
    Lei Huang
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 2:702-6. 2003
    The DF3/MUC1 mucin-like transmembrane oncoprotein is overexpressed by most human carcinomas...
  93. ncbi MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1
    Jennifer J Rahn
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada
    J Biol Chem 279:29386-90. 2004
    The MUC1 mucin is normally restricted to the apical surface of breast epithelial cells. In tumors, it is frequently overexpressed and underglycosylated...
  94. ncbi Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    Xiaolong Wei
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Cell 7:167-78. 2005
    The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas. The present work demonstrates that MUC1 associates with the p53 tumor suppressor, and that this interaction is increased by genotoxic stress...
  95. pmc Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue
    Shi fang Yuan
    Department of Vascular and Endocrine Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    World J Gastroenterol 11:4661-6. 2005
    To investigate the relation between MUC1 expression, distribution, and prognosis in hepatocellular and cholangiocarcinoma (HCC and CC) and cirrhotic liver tissues, and their significance in HCC and CC diagnosis.
  96. ncbi MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1
    Jennifer J Rahn
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada
    Clin Exp Metastasis 22:475-83. 2005
    b>MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually all breast cancers...
  97. ncbi The mucin-1 568 adenosine to guanine polymorphism influences serum Krebs von den Lungen-6 levels
    Rob Janssen
    Department of Pulmonology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands
    Am J Respir Cell Mol Biol 34:496-9. 2006
    ..this study was to analyze whether serum KL-6 levels are dependent on the functional adenosine to guanine mucin-1 (MUC1) gene polymorphism at nucleotide position 568 in a well-characterized white population...
  98. ncbi MUC1 oncoprotein stabilizes and activates estrogen receptor alpha
    Xiaolong Wei
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 21:295-305. 2006
    The MUC1 protein is aberrantly overexpressed by most human breast carcinomas. We report that the MUC1 C-terminal subunit associates with estrogen receptor alpha (ERalpha) and that this interaction is stimulated by 17beta-estradiol (E2)...
  99. pmc MUC-1 gene is associated with prostate cancer death: a 20-year follow-up of a population-based study in Sweden
    O Andrén
    Department of Urology, Orebro University Hospital, Orebro, Sweden
    Br J Cancer 97:730-4. 2007
    ..3-128) times higher risk to die in prostate cancer compared with men with Gleason score <7 and normal MUC-1 intensity. In summary, our data show that MUC-1 is an independent prognostic marker for prostate cancer death...
  100. pmc Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer
    Thomas A Sellers
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Epidemiol Biomarkers Prev 17:397-404. 2008
    Studies suggest that underglycosylation of the cell membrane mucin MUC1 may be associated with epithelial ovarian cancer...
  101. pmc Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells
    Natália R Costa
    Institute of Molecular Pathology and Immunology, University of Porto, Porto 4200 465, Portugal
    World J Gastroenterol 14:1411-4. 2008
    To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells.

Research Grants77

  1. Jia Luo; Fiscal Year: 2016
    ..We also reveal that the human transmembrane mucin (MUC1) is highly sensitive to alcohol...
  2. Venu Raman; Fiscal Year: 2015
    ..In our recent studies, a direct association between Twist expression and the dysregulation of Mucin 1 (MUC1) was demonstrated in breast cancer cells...
  3. Anna Moore; Fiscal Year: 2016
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. ..
  4. Matthew B Renfrow; Fiscal Year: 2016
    ..Mucins, such as membrane-associated MUC1, are perhaps the best known family of proteins that are heavily O-glycosylated...
  5. Studies on the Post-translational processing of MUC1
    Michael A Hollingsworth; Fiscal Year: 2012
    ..proposes experiments that will further explore the molecular mechanisms by which the cell surface associated mucin, MUC1, contributes to the progression of pancreatic adenocarcinoma...
  6. RODNEY JON SCHLOSSER; Fiscal Year: 2014
    ..We will simultaneously coat NPs with SOD and/or CAT and a targeting antibody (Ab) to mucin 1 (MUC1), which binds to the luminal surface of airway epithelial cells...
  7. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    b>MUC1 (MUC1 in human and Muc1 in non-humans) is a transmembrane mucin-like glycoprotein highly expressed in various cancer cells and its expression has also been shown in various normal epithelial cells as well as hematopoietic cells...
  8. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010
    ..Our published studies demonstrated that MUC1 mucin (MUC1 in humans, Muc1 in animals) is another pattern recognition receptor expressed on the surface of ..
  9. Jeffrey S Souris; Fiscal Year: 2016
    ..lectins/aptamers/peptides that target M-T stage-dependent, aberrant polyp glycan/glycoprotein expression (mucins MUC1 and MUC15, mucin-like tumor-associated glycoprotein TAG-72, and mucin surface glycan [unreadable]-L-fucose)...
  10. Pi Wan Cheng; Fiscal Year: 2015
    ..A549 and H292 cells with and without heat shock will be the test models because they express C2GnT-L, C2GnT-M, MUC1 and MUC5AC, which allows assessment of changes in mucin glycan structures in these two mucins following disruption ..
  11. Control of Mucin Glycan Branching in Membrane-bound and Secreted Mucins
    Pi Wan Cheng; Fiscal Year: 2010
    ..are to demonstrate that: (1) overexpression of C2GnT-M would not affect the levels of core 2 structure in MUC1 and overexpression of C2GnT-L would not affect the levels of core 2 structure in MUC5AC, (2) targeting C2GnT-M and ..
  12. Bacteria-Mucin Interactions at the Ocular Surface
    Ilene K Gipson; Fiscal Year: 2012
    ..epithelial cell lines expressing apically the glycosylated membrane-associated mucins found in native epithelia (MUC1, 4 and 16) and 3 clinical isolates-SA, SPE, and SPN-all derived from ocular surface infections...
  13. Modulation of MUC1 Mucin Trafficking
    Rebecca P Hughey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human MUC1 is a membrane glycoprotein that is expressed on the apical surface of many secretory epithelial cells...
  14. FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTION
    Gordon C Douglas; Fiscal Year: 2013
    ..endothelium? Based on new data, we have developed a hypothesis that invokes new roles for the cell-surface mucin, MUC1. These data show that (1) FSS-mediated upregulation of [unreadable]1 integrin is attenuated in trophoblasts in ..
  15. Sandra J Gendler; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): MUC1 is a tumor-associated antigen involved in oncogenesis, regulation of cellular signaling and transcription and protection of epithelial surfaces...
  16. DANIEL WILLIAM CRAMER; Fiscal Year: 2015
    ..through events that either increase or decrease immunity to the important epithelial cell and cancer marker, MUC1 (in the same family as CA125)...
  17. Immunotherapy to prevent oral permalignant lesion recurrence and oral cancer.
    M Rita Young; Fiscal Year: 2013
    ..are epidermal growth factor receptor (EGFR), the receptor for advanced glycation end products (RAGE) and the MUC1 mucin. The specific aims that will test our hypothesis are: 1...
  18. GLYCOPROTEIN MARKERS OF UTERINE RECEPTIVITY
    Daniel D Carson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): MUC1 is a large mucin glycoprotein abundantly expressed at the apical surface of uterine epithelia and protects the uterus from enzymatic and microbial attack...
  19. T CELL IMMUNITY TO EPITHELIAL TUMOR MUCINS
    Olivera J Finn; Fiscal Year: 2013
    ABSTRACT Epithelial cell glycoprotein MUC1 is overexpressed and hypoglycosylated on all human adenocarcinomas and is recognized by the immune system as a tumor antigen...
  20. Hans Christian Reinecker; Fiscal Year: 2016
    ..We demonstrated previously that IL-22 stimulates epithelial cells to produce a mucin 1 (Muc1), a major component in intestinal mucus...
  21. Carolyn R Bertozzi; Fiscal Year: 2016
    ..In collaborative work with Prof. Valerie Weaver (UCSF) we used the glycopolymers as models of MUC1, a cell-surface mucin that is overexpressed on many cancers...
  22. Synthesis of MUC1 glycopeptides and generation of antibodies for the indentificat
    Katja Michael; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Synthesis of MUC1 glycopeptides and generation of antibodies for the identification of epitopes on cancer cells...
  23. Anda M Vlad; Fiscal Year: 2016
    ..Our recently developed transgenic mice express human mucin 1 (MUC1), a glycoprotein important in the development and therapy of ovarian cancer...
  24. Donald W Kufe; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Mucin 1 (MUC1) is aberrantly overexpressed in ~90% of human breast cancers and, as such, has been regarded as a highly attractive target for the development of new anti-cancer agents...
  25. MUC1 AND RESISTANCE OF CANCER CELLS TO ONCOLYTIC VIROTHERAPY
    VALERY ZURABOVICH GRDZELISHVILI; Fiscal Year: 2012
    ..The major objective of this Academic Research Enhancement Award (AREA) R15 proposal is to evaluate the role of MUC1 protein, a member of the mucin family, in resistance of pancreatic cancer cells to oncolytic viruses (OV)...
  26. Pinku Mukherjee; Fiscal Year: 2014
    ..b>MUC1 is a transmembrane mucin glycoprotein that is significantly increased and differentially glycosylated in over 60% ..
  27. Kwang Chul Kim; Fiscal Year: 2015
    ..Recently we discovered that MUC1, one of the membrane-tethered mucins expressed on the apical surface of airway epithelial cells, has an ability to ..
  28. KWOK KIN WONG; Fiscal Year: 2016
    ..b>Mucin 1 (MUC1) is a transmembrane glycoprotein that is overexpressed in most NSCLCs...
  29. Breast PETX: Mammography Machine PET Scanner with Biopsy Guidance
    Lawrence R MacDonald; Fiscal Year: 2010
    ..system is that it will be a true tomographic imaging PET device, rather than a positron emission mammographic (PEM) scanner. Thus the PET images will be quantitative, unlike PEM...
  30. Dietary Protein Requirements in Hemodialysis Patients
    Joel Kopple; Fiscal Year: 2007
    ..by applicant): A high proportion of maintenance hemodialysis (MHD) patients have protein-energy malnutrition (PEM), which is a powerful predictor of high morbidity and mortality...
  31. Effects of MUC1 expression on erbB activity in neoplasia
    Joyce A Schroeder; Fiscal Year: 2010
    ..The tumor antigen MUC1 is also commonly overexpressed on breast cancer epithelium, associates with and is phosphorylated by erbB receptor ..
  32. Jordan M Winter; Fiscal Year: 2014
    ..Based on this work, MUC1 was identified as the best candidate promoter for transcriptionally-driven nanotherapy, since it was tightly ..
  33. Prognostic Molecular Markers of Colorectal Cancer
    Upender Manne; Fiscal Year: 2009
    ..IHC) are: DCC (deleted in colon cancer), p53, p21waf-1, p27Kip-1, Mdm2, cyclin E, Ki67, Bcl-2, Bax, MUC1, cyclooxygenase 2, and thymidylate synthase. The extent of apoptosis will be determined utilizing TUNEL...
  34. MUC1 enhances Neuropilin-1 signaling in pancreatic ductal adenocarcinoma
    Pinku Mukherjee; Fiscal Year: 2013
    ..b>MUC1 is a glycoprotein that is over-expressed and aberrantly glycosylated in over 60% of PC and 100% of PC metastases...
  35. Pankaj Kumar Singh; Fiscal Year: 2016
    ..b>MUC1 overexpression is associated with aggressive (invasive and metastatic) forms of pancreatic and other cancers...
  36. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Indeed, targeted deletion of one of these genes, Rhox5 (Pem), results in male subfertility, marked by increased germ-cell apoptosis and abnormal sperm motility...
  37. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..Aim 1a. Determine the effect of puPAR, pMMP-9 and pUM in combination with radiation on the levels of uPAR and MMP-9 in medulloblastoma cell lines. Aim 1b...
  38. Hans Schreiber; Fiscal Year: 2016
    ..Aim 3 is to generate and evaluate CARs recognizing Tn-O-glycopeptide epitopes on the deglycosylated form of MUC1 found in human cancers...
  39. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry L Orr-Weaver; Fiscal Year: 2013
    ..will be deciphered, and the mechanism by which it promotes translation will be defined, particularly its relationship to the translational repressor PUMILIO (PUM). Additional targets of PNG and interacting proteins will be isolated.
  40. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..Using a genetic approach, we have identified the first A. actinomycetemcomitans collagen adhesin, Ema (extracellular matrix protein adhesin) A and multiple genes involved in regulating the expression of ECM protein ..
  41. Emotion Regulation in Adolescence: A Social Affective Neuroscience Approach
    JENNIFER S contact SILK; Fiscal Year: 2010
    ..affective interactions with concurrent pupillary data;and (c) a cell-phone based Ecological Momentary Assessment (EMA) protocol measuring adolescents'emotional reactivity and regulation in natural social contexts...
  42. Heathy Bodies, Healthy Minds: Helping Adolescents with PCOS
    Dana L Rofey; Fiscal Year: 2013
    ..valid measurements within the adolescents'real-world environment utilizing ecological momentary assessment (EMA)...
  43. Corby K Martin; Fiscal Year: 2014
    ..receive automated prompts (emails) on the Smartphone that are consistent with Ecological Momentary Assessment (EMA) methodology reminding them to take pictures of their foods...
  44. Elizabeth R Gavis; Fiscal Year: 2016
    ..In the early embryo, Nos protein forms a translational repressor complex with its partner Pumilio (Pum) to silence genes that inhibit abdominal and germline development...
  45. DIFFERENTIATING AGENTS IN HEMATOLOGIC MALIGNANCIES
    Donald W Kufe; Fiscal Year: 2012
    ..Other work has indicated that the MUC1 oncoprotein, which is aberrantly expressed by diverse hematologic malignancies, blocks ROS-induced differentiation ..
  46. JOSEPH VINCENT BONVENTRE; Fiscal Year: 2016
    ..We have also conducted definitive studies in the rat that led the FDA, EMA and Japanese regulatory agency to qualify Kim-1 (which we discovered) for preclinical evaluation of nephrotoxicity...
  47. Self-monitoring using GPS- and accelerometer-equipped smartphones
    NITHYA RAMANATHAN; Fiscal Year: 2010
    ..To avoid these sources of error and delay, ecological momentary assessment (EMA) was developed to monitor affect and behavior in real time in a person's natural environment...
  48. Polly Ryan; Fiscal Year: 2015
    ..health behavior change and evaluate differences within and between subjects using Ecological Momentary Assessments (EMA) as a complement to traditional measures and 4) evaluate the utility of The Individual and Family Self-Management ..
  49. Eric L Granholm; Fiscal Year: 2015
    ..We need a low cost, efficient, more objective measure, which is what Ecological Momentary Assessment (EMA) can provide...
  50. Geert Jan Boons; Fiscal Year: 2015
    ..the fully synthetic multi-component vaccine candidates by examining various in-build adjuvants, employ foreign and MUC1-derived helper T- epitopes and use carbohydrates of increasing complexity...
  51. Using Ecolog. Momentary Assess. To Examine Pain & Smoking In Head & Neck Cancer P
    CHO YAN LAM; Fiscal Year: 2010
    ..The proposed project is a naturalistic study that uses ecological momentary assessment (EMA) to assess pain, cigarette use, and other smoking-related variables in head and neck cancer patients who smoke ..
  52. David M Williams; Fiscal Year: 2015
    ..Regardless of treatment outcomes, the proposed EMA protocol will provide a rich source of data to conduct a detailed examination of the determinants of smoking lapses ..
  53. Biological correlates of altered brain growth in autism
    SHERMAN MORTON WEISSMAN; Fiscal Year: 2010
    ..cell survival and genome wide structural variation such as copy number variations (CNVs) by paired end mapping (PEM) and array capture and sequencing...
  54. Training Leaders to Improve Healthcare Quality in Emergency Settings for Children
    Charles Macias; Fiscal Year: 2009
    ..this proposal is to host a conference that will maximize knowledge and skills of the Pediatric Emergency Medicine (PEM) workforce in order to deliver the highest quality emergency care to children...
  55. Mechanisms of Immune Modulation Mediated by Yeast-derived Particulate Beta-Glucan
    Jun Yan; Fiscal Year: 2012
    ..Lewis lung carcinoma transfected with surrogate antigen ovalbumin and tumor-associated antigen MUC1 will be used as the model systems to address those issues...
  56. Pathik D Wadhwa; Fiscal Year: 2014
    ..Recent advances in ecological momentary assessment (EMA) sampling methods now afford the opportunity of assessing the dynamic interplay of psychological, behavioral and ..
  57. THERESA ANN NICKLAS; Fiscal Year: 2015
    ..Consistent with Ecological Momentary Assessment (EMA) methodology, automated prompts are sent to participants'Smartphone's reminding them to capture and send ..
  58. Mary Lou King; Fiscal Year: 2016
    ..Nanos and Dazl both interact with another (sequence-specific) RNA-binding protein, Pumilio (Pum), to regulate translation, but with opposite effects: Nanos represses translation of target RNAs, while Dazl ..
  59. JENNIFER LYNN PEARSON; Fiscal Year: 2014
    ..Our observational study features three weeks of concurrent ecological momentary assessment (EMA) and in-depth interview data collection, followed by a 30-day follow-up telephone contact to assess cigarette and ..
  60. Benjamin Tycko; Fiscal Year: 2015
    ..a) prenatal distress (daily life stress assessed 3x in pregnancy using 24-hour Ecological Momentary Assessment (EMA) via a Personal Digi- tal Assistant (PDA)) and mood symptoms elicited by clinician interviews) predict women's ..
  61. Evan M Forman; Fiscal Year: 2016
    ..our recent work using lab-based behavioral measures and repeatedly-administered, ecological momentary assessment (EMA) to better understand the challenges of adopting and maintaining healthful behavior choices, we will use both these ..
  62. Richard H Ebright; Fiscal Year: 2016
    ..nucleoside-analog inhibitor (NAI) that selectively inhibits bacterial RNA polymerase (RNAP): pseudouridimycin (PUM). PUM is produced by Streptomyces sp...
  63. Oral Health Outcomes of Early Childhood Malnutrition
    Walter Psoter; Fiscal Year: 2006
    ..objectives of this retrospective cohort study are to assess the impact of early protein-energy malnutrition (PEM) on the permanent dentition, specifically with respect to: 1) dental caries, 2) enamel hypoplasia, 3) tooth ..
  64. Ecological Momentary Assessment in Hearing Disorders
    James Henry; Fiscal Year: 2009
    ..clinical researchers in a variety of fields have turned to a technique known as ecological momentary assessment or EMA. In essence, a standard Personal Digital Assistant (PDA) is programmed to signal a patient/participant with an ..
  65. Pem Homeobox Gene Function During Spermatogenesis
    J Suzanne Lindsey; Fiscal Year: 2004
    ..The only testosterone-regulated, Sertoli cell-specific gene known to date is the Pem homeobox gene...
  66. Transcriptional Control of Placental Development
    Yaacov Barak; Fiscal Year: 2007
    ..Other preliminary studies identified the mucin-1 (muc1) gene as a tight transcriptional target of PPARg in the placenta and trophoblast stem cells, and analyzed its ..
  67. Adherence to Self-Paced vs Prescribed Intensity PA: Exploring Mechanisms via EMA
    David M Williams; Fiscal Year: 2010
    ..responses to exercise as a predictor of adherence to the exercise program using ecological momentary assessment (EMA;i.e., electronic diaries)...
  68. In Vivo Assessment of Young Adults' Exposure to Cigarette Advertising
    William G Shadel; Fiscal Year: 2010
    ..The Overall Aim of this revised (A1) project is to adapt ecological momentary assessment (EMA) to address these questions...
  69. Probability-Sampling Framework for Modeling the Impact of Time-Varying Covariates
    STEPHEN L RATHBUN; Fiscal Year: 2010
    ..events to support collaborative efforts to model two existing data sets involving Ecological Momentary Assessment (EMA) of smoking...