mu opioid receptor

Summary

Gene Symbol: mu opioid receptor
Description: opioid receptor mu 1
Alias: LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, mu-type opioid receptor, mu opiate receptor, mu opioid receptor hMOR-1a
Species: human

Top Publications

  1. doi A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
    Alex T Sia
    Department of Women s Anaesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore
    Anesthesiology 109:520-6. 2008
  2. ncbi A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
  3. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010
  4. ncbi Environmental and genetic factors associated with morphine response in the postoperative period
    Laurent Coulbault
    Pharmacology Department, Saint Antoine University of Medicine, University Pierre et Marie Curie, Paris, France
    Clin Pharmacol Ther 79:316-24. 2006
  5. ncbi The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    Thomas Kroslak
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    J Neurochem 103:77-87. 2007
  6. doi A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels
    Eduardo J Lopez Soto
    Laboratory of Electrophysiology, Multidisciplinary Institute of Cell Biology, Argentine Research Council CONICET and Scientific Research Commission of Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina
    Neurosci Lett 523:190-4. 2012
  7. pmc Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction
    C Bond
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Proc Natl Acad Sci U S A 95:9608-13. 1998
  8. doi Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction
    Ishani Deb
    Neurobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    J Neurochem 112:486-96. 2010
  9. pmc The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status
    Helen Vossen
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 5:e13641. 2010
  10. doi A118G polymorphism of OPRM1 gene is associated with schizophrenia
    Omar Sery
    Laboratory of neurobiology and molecular psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37, Brno, Czech Republic
    J Mol Neurosci 41:219-22. 2010

Detail Information

Publications258 found, 100 shown here

  1. doi A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
    Alex T Sia
    Department of Women s Anaesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore
    Anesthesiology 109:520-6. 2008
    ..The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia...
  2. ncbi A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  3. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010
    ....
  4. ncbi Environmental and genetic factors associated with morphine response in the postoperative period
    Laurent Coulbault
    Pharmacology Department, Saint Antoine University of Medicine, University Pierre et Marie Curie, Paris, France
    Clin Pharmacol Ther 79:316-24. 2006
    ..The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery...
  5. ncbi The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    Thomas Kroslak
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    J Neurochem 103:77-87. 2007
    The most common single nucleotide polymorphism in the coding region of the human mu opioid receptor gene is the A118G variant, an adenine to guanine transition at nucleotide position 118 of the coding sequence of the gene...
  6. doi A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels
    Eduardo J Lopez Soto
    Laboratory of Electrophysiology, Multidisciplinary Institute of Cell Biology, Argentine Research Council CONICET and Scientific Research Commission of Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina
    Neurosci Lett 523:190-4. 2012
    ..2e37b currents. Our study demonstrates that this common site of OPRM1 polymorphism affects the inhibitory actions of MORs on both major Ca(V)2.2 isoforms expressed in nociceptors...
  7. pmc Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction
    C Bond
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Proc Natl Acad Sci U S A 95:9608-13. 1998
    ..The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and ..
  8. doi Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction
    Ishani Deb
    Neurobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    J Neurochem 112:486-96. 2010
    ..Results suggest that the association of A118G polymorphism to heroin and alcohol addiction may be because of the altered regulation of PKA and pERK1/2 during opioid and alcohol exposures...
  9. pmc The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status
    Helen Vossen
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 5:e13641. 2010
    ..In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used...
  10. doi A118G polymorphism of OPRM1 gene is associated with schizophrenia
    Omar Sery
    Laboratory of neurobiology and molecular psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37, Brno, Czech Republic
    J Mol Neurosci 41:219-22. 2010
    ..The neuronal myelination seems to be one of the important factors in the pathogenesis of schizophrenia...
  11. ncbi Characterization of the 3' untranslated region of the human mu-opioid receptor (MOR-1) mRNA
    Soichiro Ide
    Division of Psychobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Gene 364:139-45. 2005
    The mu-opioid receptor (MOR) plays a mandatory role in the action of most opioid drugs, such as morphine, fentanyl, and heroin...
  12. ncbi HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells
    Jose A Beltran
    Department of Biology, Seton Hall University, McNulty Hall, Room 215, South Orange, NJ 07079, USA
    Int Immunopharmacol 6:1459-67. 2006
    ..Opioid abuse has been shown to exacerbate the immunosuppressive effects and pathogenesis of HIV infection. The mu opioid receptor (MOR) is present on immune cells, such as macrophages, and mediates the direct immunomodulatory effects of ..
  13. pmc A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases
    Shaily Malik
    Cellular and Molecular Neuroscience, National Brain Research Center, Manesar, Gurgaon, Haryana, India
    PLoS ONE 6:e18116. 2011
    ..We have also showed for the first time that PDGF-BB can protect against simultaneous exposure of Tat and morphine, strengthening its role as a neuroprotective agent that could be considered for therapeutic intervention...
  14. ncbi Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
    Jorn Lotsch
    Pharmazentrum Frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Anesthesiology 97:814-9. 2002
    ....
  15. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study...
  16. pmc Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model
    Sulie L Chang
    Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Virol 81:8406-11. 2007
    Opioids, via the mu opioid receptor (MOR), can exacerbate bacterial infections and the immunopathogenesis of human immunodeficiency virus type 1 (HIV-1) infection...
  17. doi The G allele of SNP E1/A118G at the mu-opioid receptor gene locus shows genomic evidence of recent positive selection
    Grace S Y Pang
    Division of Medical Sciences, National Cancer Center, Level 6, Lab 5, Singapore 169610, Singapore
    Pharmacogenomics 10:1101-9. 2009
    Opioid drug response and pain perception differs greatly amongst different individuals. The micro-opioid receptor (MOR) is the main receptor target for important opioid analgesics...
  18. pmc Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection
    Baldwin M Way
    Department of Psychology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:15079-84. 2009
    ..Taken together, these data suggest that the A118G polymorphism specifically, and the mu-opioid receptor more generally, are involved in social pain in addition to physical pain...
  19. ncbi Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    The mu-opioid receptor (MOR) mediates reward and dependence associated with opioids and other commonly abused substances. Variability in the MOR gene, OPRM1, may influence risk for opioid dependence...
  20. ncbi Mu opioid receptor gene variants: lack of association with alcohol dependence
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Mol Psychiatry 2:490-4. 1997
    The mu opioid receptor is implicated in the reward, tolerance and withdrawal effects of alcohol and other drugs of abuse...
  21. pmc The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses
    G R Uhl
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 96:7752-5. 1999
    There are differences between human individuals and between mouse strains in levels of mu opiate receptor (muOR) expression, responses to painful stimuli, and responses to opiate drugs...
  22. ncbi Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence
    P Franke
    Department of Psychiatry University of Bonn, Germany
    Am J Med Genet 105:114-9. 2001
    ..In addition, there was no significant association between the endophenotype of the individuals under study (e.g., comorbidity, severity of illness) and a particular genotype of OPRM1...
  23. ncbi The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 26:106-14. 2002
    ..It is plausible that persons expressing the mu-opioid receptor variant have altered HPA axis dynamics and altered responses to other physiological processes regulated through activation of the mu-opioid receptor...
  24. ncbi Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking
    Irma Onoprishvili
    Department of Psychiatry, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Mol Pharmacol 64:1092-100. 2003
    The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin...
  25. ncbi The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial
    C Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA
    Pharmacogenomics J 4:184-92. 2004
    ..Smokers who carry the OPRM1 Asp40 variant are likely to have a favorable response to TN and may benefit from extended therapy with the 21 mg dose...
  26. ncbi The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    P Klepstad
    Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 48:1232-9. 2004
    ..The purpose of the study was to investigate whether this and other genetic polymorphisms in OPRM1 influence the efficacy of morphine in cancer pain patients...
  27. ncbi Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 30:417-22. 2005
    The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies...
  28. ncbi Gene polymorphisms of the mu opioid receptor in methamphetamine abusers
    Soichiro Ide
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:316-24. 2004
    ..We have investigated associations of the mu-opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis...
  29. ncbi A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans
    Lara A Ray
    University of Colorado, Boulder, CO 80309 0345, USA
    Alcohol Clin Exp Res 28:1789-95. 2004
    ..The goal of this study was to test whether the A118G polymorphism is associated with sensitivity to the effects of alcohol...
  30. ncbi The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    Roger B Fillingim
    University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Pain 6:159-67. 2005
    ..The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed...
  31. ncbi Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm
    L Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neuroscience 133:209-20. 2005
    The mu opioid receptor plays an important role in mediating the actions of morphine and morphine-like drugs...
  32. ncbi The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:204-11. 2006
    A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase beta-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) neurons...
  33. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  34. ncbi Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy
    Wen Ying Chou
    Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Taipei, Taiwan
    Anesthesiology 105:334-7. 2006
    ..The purpose of the current study was to investigate whether this polymorphism contributes to the variability of morphine efficacy in women who undergo abdominal total hysterectomy...
  35. ncbi The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Behav Neurosci 120:1218-24. 2006
    ..6% of the cases as carriers or noncarriers of the allele. The OPRM1 118A > G polymorphism specifically modulates nociceptive but not nonnociceptive cortical activation...
  36. pmc Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 90:159-65. 2007
    ....
  37. ncbi Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Pharmacogenet Genomics 17:1031-8. 2007
    ....
  38. pmc An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study
    Raymond F Anton
    Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Arch Gen Psychiatry 65:135-44. 2008
    ..Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response...
  39. doi Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype
    Masakazu Hayashida
    Division of Psychobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Pharmacogenomics 9:1605-16. 2008
    ..Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements...
  40. pmc Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior
    Whitney M Pratt
    Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Alcohol 44:358-65. 2009
    ..The present study sought to investigate the relationship between the HPA axis reactivity to stress, the endogenous opioid system and stress-induced drinking behavior...
  41. doi Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating
    Caroline A Davis
    Department of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada
    Obesity (Silver Spring) 17:1220-5. 2009
    ....
  42. pmc Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T
    Takeshi Ono
    Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawaku, Tokyo 142 0063, Japan
    J Biol Chem 284:20175-83. 2009
    Micro opioid receptor (MOR) agonists such as morphine are applied widely in clinical practice as pain therapy...
  43. pmc Initial evidence of an association between OPRM1 and adolescent alcohol misuse
    Robert Miranda
    Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 34:112-22. 2010
    ....
  44. pmc Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence
    Jay Jin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    BMC Neurosci 11:33. 2010
    ..The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR)...
  45. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
    Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine...
  46. pmc Cortical opioid markers in schizophrenia and across postnatal development
    David W Volk
    Department of Psychiatry, University of Pittsburgh, W1655 BST, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 22:1215-23. 2012
    ..opioids suppress GABA neuron activity, we conducted the first study to determine 1) whether the μ opioid receptor (MOR), δ opioid receptor (DOR), and opioid ligand proenkephalin are altered in the PFC of a large cohort of ..
  47. ncbi Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment
    J B Wang
    Molecular Neurobiology Branch, NIDA, Baltimore, MD 21224
    FEBS Lett 338:217-22. 1994
    A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA. The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence...
  48. ncbi Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain
    L A Bare
    Ohmeda PPD, Murray Hill, NJ 07974
    FEBS Lett 354:213-6. 1994
    A partial mu opioid receptor gene was isolated from a human genomic library using a mouse delta opioid receptor cDNA as a probe...
  49. ncbi Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence
    M R Hoehe
    Genome Research, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Hum Mol Genet 9:2895-908. 2000
    ..Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in ..
  50. ncbi A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances
    J A Schinka
    The Roskamp Institute, University of South Florida, Tampa, FL 33620, USA
    Mol Psychiatry 7:224-8. 2002
    ..The contribution of the gene to risk for substance dependence is small, and is detected most easily in studies that use control samples that are screened for all forms of substance dependence...
  51. ncbi Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin
    Jinxiu Shi
    Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    Hum Mutat 19:459-60. 2002
    ..Thus our study further highlights the importance of studing the various regions of the mu opioid receptor gene, coding as well as non-coding, for genetic markers that may be linked to, or directly contribute to ..
  52. ncbi Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
    The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described...
  53. ncbi Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 118:60-5. 2003
    ..The polymorphism occurs commonly in European Americans and some other population groups, underscoring its potential phenotypic significance...
  54. ncbi Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations
    Ene Choo Tan
    Defence Medical Research Institute, Defence Science and Technology Agency, 04 07 Clinical Research Centre, 10 Medical Drive, Singapore 117597
    Neuroreport 14:569-72. 2003
    The distribution of three polymorphisms of the mu opioid receptor gene (OPRM1) was investigated in four different Asian populations, and in heroin-dependent subjects deriving from three of these populations...
  55. ncbi Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, Old Westbury, NY 11568, USA
    J Immunol 170:5118-23. 2003
    Studies from our laboratory have revealed a novel mu opiate receptor, mu 3, which is expressed in both vascular tissues and leukocytes. The mu 3 receptor is selective for opiate alkaloids and is insensitive to opioid peptides...
  56. ncbi Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 120:97-108. 2003
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific...
  57. ncbi Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    Manuela Pfeiffer
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 278:51630-7. 2003
    The micro-opioid receptor (MOR1) and the substance P receptor (NK1) coexist and functionally interact in nociceptive brain regions; however, a molecular basis for this interaction has not been established...
  58. ncbi Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia
    Ene Choo Tan
    Schizophr Res 65:61-3. 2003
  59. ncbi Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden
    G Bart
    Mol Psychiatry 9:547-9. 2004
  60. ncbi Association of functional opioid receptor genotypes with alcohol dependence in Koreans
    Sung Gon Kim
    Department of Psychiatry, Pusan National University, Pusan, Korea
    Alcohol Clin Exp Res 28:986-90. 2004
    ..This study compared Koreans with one or two copies of the A118G polymorphism seeking treatment for alcohol dependence with a group of non-alcohol-dependent controls...
  61. ncbi Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients
    Soon Ae Kim
    Department of Pharmacology, Eulji University School of Medicine, 143 5 Yongdu Dong, Jung Gu, Daejeon, 301 832, Korea
    Alcohol 34:115-20. 2004
    ..The polymorphisms of ADH2, ALDH2, and CYP2E1 were significantly different in Korean patients with alcoholism and Korean control subjects without alcoholism, but ADH3 and OPRM1 did not differ between the two groups...
  62. ncbi Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:32618-24. 2005
    As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction...
  63. ncbi Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis
    Albert Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 83:262-8. 2006
    ..Studies examining the association of the mu-opioid receptor gene (genetic locus OPRM1) with substance dependence (SD) have focused on the Asn40Asp (A118G) single nucleotide polymorphism (SNP)...
  64. ncbi Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms
    S Ide
    Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan
    Pharmacogenomics J 6:179-88. 2006
    ..There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis...
  65. ncbi The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor
    Hack Sun Choi
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 343:1132-40. 2006
    ..actions of morphine and morphine-like drugs, such as heroin, mediate primarily through the mu-opioid receptor (MOR). It has been proposed that the functional diversity of MOR may be related to alternative splicing of the MOR gene...
  66. ncbi Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 31:2313-7. 2006
    The mu opioid receptor is centrally involved in the development of the addictive diseases. It also modulates the stress responsive hypothalamic-pituitary-adrenal axis...
  67. ncbi Genomic variations and transcriptional regulation of the human mu-opioid receptor gene
    Bettina Bayerer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Pain 11:421-7. 2007
    The mu-opioid receptor (MOR1) is a target of endogenous and exogenous opioids and plays a pivotal role for anesthesia and analgesia...
  68. ncbi Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty
    W Y Chou
    Department of Anaesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Acta Anaesthesiol Scand 50:787-92. 2006
    ..This study was performed to correlate the A118G polymorphism at OPRM1 with morphine consumption in patients undergoing total knee arthroplasty...
  69. pmc Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
    Cielito C Reyes-Gibby
    Department of Epidemiology, U T M D Anderson Cancer Center, Houston, TX, USA
    Pain 130:25-30. 2007
    ..Future studies are needed to further characterize the joint effects of multiple genes, along with demographic and clinical variables, in predicting opioid dose...
  70. ncbi Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population
    Dandan Zhang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, West Lafayette, Indiana, USA
    Biol Psychiatry 61:1244-51. 2007
    ..Genetic factors that influence subjective responses to drug use (such as euphoria) contribute to the risk of addiction. mu-opioid receptor is the molecular target of heroin mediating its effects in both pain relief and euphoria...
  71. ncbi A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers
    Esther van den Wildenberg
    Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Alcohol Clin Exp Res 31:1-10. 2007
    ..This study investigated the influence of the A118G polymorphism on cue reactivity after exposure to an alcoholic beverage in male heavy drinkers...
  72. ncbi Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study
    Joel Gelernter
    VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 31:555-63. 2007
    ..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)...
  73. ncbi The opioid system in alcohol and drug dependence: family-based association study
    Xiaoling Xuei
    Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA
    Am J Med Genet B Neuropsychiatr Genet 144:877-84. 2007
    ....
  74. ncbi Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Arch Gen Psychiatry 64:1069-77. 2007
    ..However, the mechanism by which naltrexone may be differentially effective as a function of the OPRM1 genotype is unclear...
  75. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
    ..This study provides a good example of the possible clinical use of pharmacogenetics...
  76. ncbi Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial
    Riju Ray
    Department of Pharmacology, and Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 9:1237-41. 2007
    ....
  77. ncbi Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans
    Carmen S van der Zwaluw
    Radboud University Nijmegen, Behavioural Science Institute, PO Box 9104, 6500 HE Nijmegen, The Netherlands
    Pharmacogenomics 8:1427-36. 2007
    ..Factors that complicate genetic research on alcohol dependence, such as gene-environment interaction, and genetic and clinical heterogeneity, are discussed...
  78. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
    ..Evidence was found for involvement of five genes in heroin addiction, the genes coding for the mu opioid receptor, the metabotropic receptors mGluR6 and mGluR8, nuclear receptor NR4A2 and cryptochrome 1 (photolyase-like)...
  79. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis...
  80. pmc Association of candidate genes with antisocial drug dependence in adolescents
    Robin P Corley
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Drug Alcohol Depend 96:90-8. 2008
    ..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes...
  81. pmc Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women
    Ruth Landau
    Department of Anesthesia, University Hospital of Geneva, Geneva, Switzerland
    Pain 139:5-14. 2008
    ..These findings for intrathecal fentanyl pharmacogenetics may have implications for patients receiving opioids in other settings...
  82. doi A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients
    Sung Gon Kim
    Department of Psychiatry, School of Medicine, Pusan National University, and Bongseng Memorial Hospital, 1 Ga 10, Ami dong, Seo Gu, Pusan, 602 739, South Korea
    Psychopharmacology (Berl) 201:611-8. 2009
    Previous studies have demonstrated an association between genetic polymorphisms of the mu opioid receptor gene (OPRM1) and response to naltrexone treatment...
  83. doi OPRM1 gene is associated with BMI in Uyghur population
    Ling Xu
    1MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Obesity (Silver Spring) 17:121-5. 2009
    ..14-2.49, P = 0.009) for rs514980, and 1.80 (95% confidence interval 1.14-2.85, P = 0.012) for rs7773995, respectively. Our observations give the evidence that OPRM1 gene is involved in the prevalence of obesity in Uyghurs...
  84. doi Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*
    C J Huang
    Department of Anaesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Anaesthesia 63:1288-95. 2008
    ..These data suggest an association between the IVS2+31G>A SNP of the OPRM1 gene and pressure pain sensitivity in healthy adult females...
  85. pmc OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach
    Gabor Oroszi
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 33:383-93. 2009
    ..Therefore we used a haplotype-based approach to capture information of other genetic variants that might predict treatment response to naltrexone in the COMBINE Study...
  86. pmc Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
    Alternative splicing of the mu opioid receptor genes to create multiple mu receptor subtypes has been demonstrated in animals and humans...
  87. pmc Expansion of the human mu-opioid receptor gene architecture: novel functional variants
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Hum Mol Genet 18:1037-51. 2009
    ..conserved internal ribosome entry site (IRES) in the 5'-UTR of a novel exon 13-containing OPRM1 isoforms (MOR-1K) and affects both mRNA levels and translation efficiency of these variants...
  88. doi Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception
    Masahiro Matsunaga
    Department of Neurology Psychosomatic Medicine, Ban Buntane Hotokukai Hospital, School of Medicine, Fujita Health University, Aichi 454 8509, Japan
    Brain Behav Immun 23:931-5. 2009
    ..These results suggest that the sensitive endogenous opioid system in carriers of the G allele may suppress proinflammatory cytokine secretion from peripheral immune cells; consequently, it may influence the health perception...
  89. pmc Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain
    Ene Choo Tan
    KK Research Centre, KK Women s and Children s Hospital, Singapore
    Mol Pain 5:32. 2009
    ..and mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery.
  90. doi Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment
    Carmen Walter
    Pharmazentrum frankfurt ZAFES, Institute for Clinical Pharmacology, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Pain 146:270-5. 2009
    ..This discourages basing personalized therapeutic concepts of pain therapy on OPRM1 118A>G genotyping at the present state of evidence...
  91. ncbi [Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?]
    Ken ichi Fukuda
    Department of Oral Health and Clinical Science, Tokyo Dental College, Suidoubashi Hospital, Tokyo 101 0061
    Masui 58:1102-8. 2009
    ..In the future, identifying SNPs might give us information to modulate the analgesic dosage of opioid individually for better pain control...
  92. pmc The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans
    Yanlei Du
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, U S A
    Alcohol Clin Exp Res 33:2103-12. 2009
    ..Objective of the current study was to examine the main and interacting effect of these 3 polymorphisms and 2 environmental factors in contribution to alcoholism in Mexican Americans...
  93. doi Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery
    Kenichi Fukuda
    Department of Oral Health and Clinical Science, Division of Dental Anesthesiology Orofacial Pain Center Suidoubashi Hospital, Tokyo Dental College, Chiyoda ku, Tokyo, Japan
    Pain 147:194-201. 2009
    ....
  94. doi Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients
    W Zhang
    Department of Anaesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Anaesthesia 65:130-5. 2010
    ..Fentanyl consumption increased in accordance with the number of 118G alleles. We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control...
  95. pmc OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models
    Stephen D Mague
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, TRL, PA 19104, USA
    Drug Alcohol Depend 108:172-82. 2010
    ..Evaluation of models that incorporate known human genetic variants into a tractable system, like the mouse, will facilitate the understanding of discrete contributions of SNPs to human disease...
  96. doi Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients
    Alfonso Troisi
    University of Rome Tor Vergata, Rome, Italy
    Soc Neurosci 6:88-97. 2011
    ..The results reported here are in agreement with the brain opioid hypothesis of social attachment and the established role of opioid transmission in mediating affiliative behavior...
  97. doi Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects
    Yuri Kolesnikov
    East Tallinn Central Hospital, Parnu mnt, 104, Tallinn, 11312, Estonia
    Anesth Analg 112:448-53. 2011
    ..In this study, we investigated whether combined catechol-O-methyltransferase and μ-opioid receptor polymorphisms contribute to the morphine response in postoperative analgesia...
  98. ncbi Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia
    W Zhang
    Department of Anesthesiology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    Minerva Anestesiol 77:33-9. 2011
    ..This study aimed to investigate whether the genetic polymorphism of OPRM1 A118G contributed to the variability in nausea and vomiting during fentanyl analgesia in patients undergoing total abdominal hysterectomy or myomectomy...
  99. pmc A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
    Peng Huang
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochem J 441:379-86. 2012
    ..Pulse-chase studies revealed that the half-life of the mature form of 118G/Asp40-hMOPR (~12 h) was shorter than that of 118A/Asn40-hMOPR (~28 h). Thus the A118G SNP reduces MOPR N-glycosylation and protein stability...
  100. pmc Ubiquitination in the first cytoplasmic loop of μ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation
    James N Hislop
    Department of Psychiatry, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:40193-204. 2011
    ..to contribute to homeostatic regulation of cellular opioid responsiveness, but mechanisms that mediate and control MOR down-regulation have not been defined...
  101. doi Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians
    Dingyan Chen
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Drug Alcohol Depend 123:1-6. 2012
    ..To better understand this relationship, ethnicity-specific meta-analyses were conducted...

Research Grants68

  1. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..seen with traditional opioids by targeting truncated 6 transmembrane domain splice variants of the mu opioid receptor MOR-1(6TM/E11). I propose to use it as a lead compound to design a library of opioid analgesics...
  2. Delta-Opioid Receptor Trafficking and Pain Inhibition
    Zhizhong Z Pan; Fiscal Year: 2012
    ..Currently, opioid analgesics, mainly mu-opioid receptor (MOR) agonists such as morphine and fentanyl, are still the most effective pain relievers available and are widely used ..
  3. Novel Glycosylated Delta Opioid Receptor Agonists for Chronic Inflammatory Pain
    Mark S Kleven; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Traditionally, Mu opioid receptor (MOR) agonists have not been given as first line treatments for neuropathic pain due to their significant adverse side effects...
  4. Agonist-Directed MOR Desensitization in Opioid Analgesic Tolerance
    Laura M Bohn; Fiscal Year: 2010
    ..Therefore, the development of a ligand that could activate the mu opioid receptor, but not invoke the ?arrestin2 interaction, may pharmacologically recapitulate the effects of morphine in ?..
  5. BIOCHEMICAL CHARACTERIZATION OF OPIOID BINDING SITES
    Gavril W Pasternak; Fiscal Year: 2013
    ..The mu opioid receptor (MOR-1) has a wide range of splice variants, with similar splicing patterns in mice, rats and humans...
  6. Development of a Novel Class for Opioid Drugs
    NIKOLAY DOKHOLYAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mu-opioid receptor (MOR) is the primary target for opioid analgesics...
  7. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..Our approach is based on an accidentally discovered receptor mutation, S4.45(196)L in the u-opioid receptor (MOR), that resulted in the ability of opioid alkaloid antagonists to activate the mutant receptor, both in vitro and in ..
  8. JOHN ELLIOTT ROBINSON; Fiscal Year: 2016
    ..The proposed training plan will provide a solid educational and professional foundation on which to pursue a career as a physician-scientist in the field of addiction medicine. ..
  9. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013
    ..We plan to validate the assay by using the m-opioid receptor (MOR) and its ligand morphine for nuclear location of the ERK2 activation pathway, since morphine is known to activate G-..
  10. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    Description (provided by applicant): Agonists acting at the 5 opioid receptor (MOR) (e.g. morphine and its analogs) are the mainstay of pain management;however there are serious adverse effects (e.g...
  11. SETH MICHAEL DEVER; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The [unreadable]-opioid receptor (MOR) is known to undergo extensive alternative splicing as numerous splice variants of MOR have been identified...
  12. Ping Yee Law; Fiscal Year: 2016
    ....
  13. Yasmin L Hurd; Fiscal Year: 2016
    ..Expanding knowledge regarding the regulation and function of mu opioid receptor, the target for heroin, directly in the human brain and in relation to genetic mutations will provide a ..
  14. Pamela E Knapp; Fiscal Year: 2016
    ..the pathological effects of HIV in the CNS though direct actions on [unreadable]-opioid receptor expressing (MOR) neurons and glia...
  15. Amygdalar neuropeptides and anxiety
    Marlene A Wilson; Fiscal Year: 2012
    ..and fear by comparing several anxiety-evoking stimuli, and elucidate the specific role of mu opioid receptors (MOR) in these different responses...
  16. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2011
    ..of several peptide agonists (including enkephalins) and of the delta, kappa and mu opioid receptors (DOR, KOR and MOR, respectively)...
  17. Gregory Scherrer; Fiscal Year: 2014
    ..of several peptide agonists (including enkephalins) and of the delta, kappa and mu opioid receptors (DOR, KOR and MOR, respectively)...
  18. Neurochemical Basis of Opiate Addiction
    HORACE LOH; Fiscal Year: 2013
    ..Our proposed studies will link the action of the various protein kinases recruited and activated by OPRM1 in the behavioral responses to the chronic drug treatment. ..
  19. Elyssa Margolis; Fiscal Year: 2015
    ..In spite of the magnitude of this problem, we only partially understand how MOR activation causes reward and leads to addiction...
  20. MORPHINE ACTIONS ON THE IMMUNE SYSTEM
    Sulie L Chang; Fiscal Year: 2012
    ..The Specific Aims are to define the molecular and cellular processes by which bacterial endotoxins modulate mu opioid receptor (MOR)- dependent pathways and how such modulation is related to the progression of endotoxin shock...
  21. Barry M Lester; Fiscal Year: 2015
    ..Finally, single nucleotide polymorphisms (SNPs) in the multi-drug resistance (MDR1), mu opioid receptor (OPRM1), and/or catechol-O-methyltransferase (COMT) genes (pharmacogenetic modulators of opioid action) will ..
  22. Allan I Basbaum; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The delta (DOR) and mu (MOR) subtypes of G protein-coupled opioid receptors are widely distributed in the central and peripheral nervous system...
  23. HORACE LOH; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cloning and gene knockout studies of the mouse mu opioid receptor (MOR) have established the functional role for MOR in mediating the pharmacological effects of morphine...
  24. Alan R Gintzler; Fiscal Year: 2014
    ..This will be tested by assessing sex-dependence of adaptations of the m-opioid receptor (MOR)-coupled regulation of spinal endomorphin (EM) 2 release to opioid tolerance and withdrawal...
  25. Chronic pain therapy through upregulation of opioid receptors
    Congying Wang; Fiscal Year: 2010
    ..Recently, we successfully designed an efficient strategy to improve opioid analgesia. We upregulate MOR expression in primary sensory neurons using a recombinant adeno-associated viral vector, i.e., rAAV2-MOR...
  26. NAIJIANG LIU; Fiscal Year: 2014
    ..t.) morphine. Hypothesized sexual dimorphic relationships among spinal ?-opioid receptors (MOR), endomorphin 2 (EM2), ?-opioid receptors (KOR) and dynorphin 1-17 (Dyn) are supported by substantial preliminary ..
  27. Identification and Characterization of mu Opioid Receptor Interacting Proteins
    Robert Levenson; Fiscal Year: 2011
    The mu-opioid receptor (MOR) mediates most of the actions of morphine and other clinically relevant analgesics as well as drugs of abuse such as heroin...
  28. Role of receptor trafficking in synaptic plasticity during morphine dependence
    Anuradha Madhavan; Fiscal Year: 2013
    ..The broad objectives of this proposal are to investigate the molecular role of mu-opioid receptor (MOR) endocytosis and recycling in morphine dependence...
  29. Prasun K Datta; Fiscal Year: 2015
    ..that IL-1B/TNF-a and morphine induced miR-146a expression is NFkB and [unreadable]mu[unreadable]-opioid receptor (MOR) dependent, and 3: To test the hypothesis that HDAC inhibitor, Sulforaphane (SFN) ameliorates IL-1B/TNF-a: and ..
  30. The Role of Protein Kinase C in Opioid Tolerance
    William L Dewey; Fiscal Year: 2010
    ..and Gq-coupled receptors play a role in some opioid tolerances and (4) that presynaptic sites contribute to both MOR desensitization and opioid tolerance in mice...
  31. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
    ..RXR activation also increased mu opioid receptor (MOR) expression...
  32. Neurochemical Basis of Opiate Addiction
    HORACE LOH; Fiscal Year: 2010
    ..Therefore, in the proposed studies, we will continue our on-going studies to investigate the role of MOR phosphorylation on morphine tolerance response...
  33. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2012
    The long term goal of this proposal is to understand the mechanisms by which the mu opioid receptor (Oprm) gene is regulated and to gain insights into the pharmacological and physiological significance of this regulation...
  34. Regulation of Clathrin-Coated Pits by the Mu-Opioid Receptor
    MANOJKUMAR AKKAPPILLIL PUTHENVEEDU; Fiscal Year: 2011
    ..activation of specific drug targets in the brain, and the main target of abused drugs is the mu- opioid receptor (MOR), a member of the G protein-coupled receptor (GPCR) family...
  35. Delta-kappa opioid receptor interactions: Ligand-dependent effects
    KELLY ANN BERG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Agonists acting at the 5 opioid receptor (MOR) (e.g. morphine and its analogs) are the mainstay of pain management;however there are serious adverse effects (e.g...
  36. Morphine tolerance in live neurons
    ERICA SAWYER LEVITT; Fiscal Year: 2013
    ..Morphine tolerance is in part due to a loss of signaling from mu opioid receptors (MOR) independent of a change in receptor levels...
  37. Role of opioid receptors in transmission of itch by spinothalamic tract neuron
    HANNAH ROSE MOSER; Fiscal Year: 2013
    ..This project will test the hypothesis that MOR agonists which cause itch excite STT neurons which carry itch information, while KOR agonists which have been used ..
  38. Angela M Ellison; Fiscal Year: 2014
    ....
  39. Lara A Ray; Fiscal Year: 2015
    ..The long-term objective of this research is to optimize alcoholism pharmacotherapy and to address health disparities by advancing pharmacogenetic studies in ethnic minority groups. ..
  40. Pharmacogenetic Response to Naltrexone for Alcohol Dependence
    David W Oslin; Fiscal Year: 2012
    ..Identification of patients responsive to treatment is vital to improving the public health agenda for reducing burden of illness ..
  41. Raymond F Anton; Fiscal Year: 2014
    ..in the COMBINE Study we have recently confirmed that a relatively common genetic variant (Asp40) in a mu opioid receptor (OPRM1) may be associated with a higher treatment response to naltrexone...
  42. NEUROBIOLOGICAL FACTORS IN VULNERABILITY TO OPIOID ABUSE
    GREGORY ELMER; Fiscal Year: 2001
    ....
  43. Cellular Regulation of Mu Opioid Receptors
    YUNHUA YU; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The mu opioid receptor (MOR) plays an important role in mediating analgesia, euphoria, and addiction through opiates such as morphine...
  44. KELLY ELIZABETH COURTNEY; Fiscal Year: 2014
    ....
  45. Role of the MAP Kinase Pathway ERK1/2 in Morphine Tolerance
    TARA MACEY; Fiscal Year: 2009
    ..Mu-opioid receptor (MOR) tolerance has been hypothesized to develop at the level of the receptor...
  46. Mu opioid agonists with reduced side effects for the treatment of pain
    Chad E Groer; Fiscal Year: 2011
    ..Recently, Herkinorin, a salvinorin A derivative, was found to be a potent and selective mu opioid receptor (MOR) agonist in vitro and in vivo...
  47. Laura M Bohn; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Opiate analgesics act at the mu opioid receptor (MOR) in humans to alleviate pain...
  48. Martin D Cheatle; Fiscal Year: 2016
    ..There has been considerable evidence from clinical and animal studies regarding the mu opioid receptor (MOR) gene (OPRM1) as critical to the rewarding and analgesic properties of opioid analgesics...
  49. MANOJKUMAR AKKAPPILLIL PUTHENVEEDU; Fiscal Year: 2014
    ..One key gene where genetic variations have been identified is OPRM1, which encodes the mu-opioid receptor (MOR), the target of many clinically abused drugs...
  50. HENRY ISAAC MOSBERG; Fiscal Year: 2016
    ..This is illustrated in the field of opioid analgesics, where the co- administration of a mu opioid receptor (MOR) agonist with a delta opioid receptor (DOR) antagonist retains the MOR-mediated analgesia but with ..
  51. Andrew C Chen; Fiscal Year: 2014
    ....
  52. Novel Glycosylated Delta Opioid Receptor Agonists for Chronic Inflammatory Pain
    KIMBERLEY GANNON; Fiscal Year: 2009
    ..An early drug candidate was identified that targeted both the 4 and 5 opioid receptors (DOR and MOR, respectively) and had improved properties over the parent peptide...
  53. A Pilot Trial of Naltrexone for Methamphetamine Addiction - Role of the A118G SNP
    E KEITH FLOWER; Fiscal Year: 2010
    ..We plan to investigate whether a long-lasting, injection form of naltrexone, which has shown efficacy in some groups with alcohol and other drug problems, may help prevent relapse in persons who are methamphetamine dependent. ..
  54. Rueben A Gonzales; Fiscal Year: 2016
    ..We propose to determine whether genetic deletion or irreversible blockade of the mu opiate receptor alters the dose-response curve for ethanol-stimulated dopamine release in the ventral striatum (aim 1)...
  55. Jennifer L Whistler; Fiscal Year: 2015
    ..We also have preliminary evidence that the DOR1 may be a heterodimer of the DOR and the mu opioid receptor (MOR)...
  56. Yan Zhang; Fiscal Year: 2016
    ..side effects (such as addiction and abuse liability) are primarily due to their interaction with the mu opioid receptor (MOR)...
  57. HORACE LOH; Fiscal Year: 2014
    ..AAMs will represent a novel class of drug molecules that can limit tolerance development during chronic opioid administration, thereby maintaining the therapeutic index of the opioid analgesic treatment paradigm. ..
  58. Jermaine D Jones; Fiscal Year: 2015
    ..Through its combination of structured mentorship, coursework, and innovative research, this award will ensure Dr. Jones'successful transition to an independent investigator. ..
  59. Derivatives of Naltrexone as Opioid Pharmacotherapies
    Stephen M Husbands; Fiscal Year: 2010
    ..potential pharmacotherapies for opiate dependence with profiles similar to buprenorphine, but having higher mu opioid receptor efficacy...
  60. HIV and Psychiatric Comorbidity: Selected Genetic and Epigenetic Factors
    Mary J Kreek; Fiscal Year: 2010
    ..The information gained from this research should help to alleviate the suffering of HIV-1 infection with comorbid psychiatric diseases. ..
  61. Functional Characterization of OPRM1 A118G in Nicotine Dependence
    Jon Kar Zubieta; Fiscal Year: 2010
    A substantial body of evidence implicates the endogenous opioid system, and the mu opioid receptor (MOR) in particular, in the reinforcing effects of drugs of abuse, including nicotine...
  62. Alcohol abuse pharmacogenomics: building naturalistic rhesus monkey models
    Gregory Miller; Fiscal Year: 2009
    ..Through the accumulation of multiple shared genotype/phenotype components, naturalistic modeling of human neurogenetic variance in rhesus monkeys can be achieved. ..
  63. Enkephalins: Neuropharmacology and Abuse Potential
    William Dewey; Fiscal Year: 2006
    Acutely administered morphine produces antinociception via mu opioid receptor (MOR)-mediated intracellular changes that include a decrease in calcium concentration, and a decrease in the activity of adenylyl cyclase and protein kinases...
  64. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007
    ..opioid analgesics, as well as abused opioids, mediate their effects by acting at mu opioid receptors (MOR)...
  65. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2006
    ..by which chronic in utero morphine and methadone exposure affect regulation and function of mu opioid receptors (MOR) in respiratory control areas of newborn brainstem...
  66. Molecular Basis of mu-Opioid Receptor Gene Regulation
    Jane Ko; Fiscal Year: 2009
    ..The critical roles of the mu-opioid receptor (MOR) in analgesia, as well as in the development of tolerance and dependence are well-established...