MTR

Summary

Gene Symbol: MTR
Description: 5-methyltetrahydrofolate-homocysteine methyltransferase
Alias: HMAG, cblG, methionine synthase, 5-methyltetrahydrofolate-homocysteine methyltransferase 1, cobalamin-dependent methionine synthase, vitamin-B12 dependent methionine synthase
Species: human

Top Publications

  1. ncbi Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    K Matsuo
    Division of Epidemiology and Prevention, the Department of Hematology and Chemotherapy, the Nagoya University Graduate School of Medicine, Japan
    Blood 97:3205-9. 2001
  2. ncbi Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases
    G Zhang
    Laboratory of Molecular Hematology, Division of Hematology, The Second Affiliated Hospital, Hunan Medical University, Changsha, Hunan 410011, China
    Thromb Res 104:187-95. 2001
  3. ncbi Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population
    Patrizia De Marco
    Istituto G Gaslini, Largo G Gaslini, 5 16148 Genova, Italy
    J Hum Genet 47:319-24. 2002
  4. ncbi The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study
    Mariska Klerk
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Thromb Res 110:87-91. 2003
  5. doi Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression
    Ana Patino-Garcia
    Laboratory of Pediatrics, University of Navarra University Clinic, Pamplona, Spain
    J Pediatr 154:688-93. 2009
  6. ncbi Cobalamin-dependent methionine synthase
    R V Banerjee
    Biophysics Research Division, University of Michigan, Ann Arbor 48109
    FASEB J 4:1450-9. 1990
  7. ncbi Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
    D Leclerc
    MRC Group in Medical Genetics, Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    Hum Mol Genet 5:1867-74. 1996
  8. ncbi 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    L D Botto
    Birth Defects and Pediatric Genetics Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 151:862-77. 2000
  9. ncbi Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men
    V Dekou
    Cardiovascular Genetics, Department of Medicine, University College London Medical School, The Rayne Institute, UK
    Thromb Haemost 85:67-74. 2001
  10. ncbi Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001

Research Grants

  1. GENETIC RISK FACTORS FOR HYPERHOMOCYSTEINEMIA
    ROY GRAVEL; Fiscal Year: 2006
  2. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
  3. Sylvia B Smith; Fiscal Year: 2016
  4. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
  5. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MARK STEEN; Fiscal Year: 2001
  6. RUMA V BANERJEE; Fiscal Year: 2016
  7. Structural Characterizations of Transient and Heterogeneous Protein Complexes
    Nozomi Ando; Fiscal Year: 2013
  8. Folic Acid Enhances Repair Mechanism in the Adult CNS
    Bermans J Iskandar; Fiscal Year: 2010
  9. GENETIC HETEROGENEITY IN HOMOCYSTEINE REMETHYLATION
    Barry Shane; Fiscal Year: 2000
  10. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004

Detail Information

Publications217 found, 100 shown here

  1. ncbi Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    K Matsuo
    Division of Epidemiology and Prevention, the Department of Hematology and Chemotherapy, the Nagoya University Graduate School of Medicine, Japan
    Blood 97:3205-9. 2001
    ..for a folate metabolic enzyme, methylenetetrahydrofolate reductase (MTHFR), and one was evaluated for methionine synthase (MS)...
  2. ncbi Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases
    G Zhang
    Laboratory of Molecular Hematology, Division of Hematology, The Second Affiliated Hospital, Hunan Medical University, Changsha, Hunan 410011, China
    Thromb Res 104:187-95. 2001
    ..methylenetetrahydrofolate reductase (MTHFR) C677T, cystathionine beta-synthase (CBS) 844ins68, and methionine synthase (MS) A2756G have been identified as genetic risk factors for thromboembolic events...
  3. ncbi Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population
    Patrizia De Marco
    Istituto G Gaslini, Largo G Gaslini, 5 16148 Genova, Italy
    J Hum Genet 47:319-24. 2002
    ..Furthermore, several studies have suggested that a defective methionine synthase ( MS) enzyme could be a critical defect in folate-related NTDs...
  4. ncbi The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study
    Mariska Klerk
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Thromb Res 110:87-91. 2003
    ..A 2756A>G polymorphism has been found in the gene (MTR) coding for methionine synthase, an enzyme catalyzing remethylation of homocysteine to methionine.
  5. doi Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression
    Ana Patino-Garcia
    Laboratory of Pediatrics, University of Navarra University Clinic, Pamplona, Spain
    J Pediatr 154:688-93. 2009
    ..To determine the influence of the genotype and the level of expression of different enzymes involved in folate metabolism on the response to and toxicity of high-dose methotrexate treatment in pediatric osteosarcomas...
  6. ncbi Cobalamin-dependent methionine synthase
    R V Banerjee
    Biophysics Research Division, University of Michigan, Ann Arbor 48109
    FASEB J 4:1450-9. 1990
    Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine...
  7. ncbi Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
    D Leclerc
    MRC Group in Medical Genetics, Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    Hum Mol Genet 5:1867-74. 1996
    b>Methionine synthase catalyzes the remethylation of homocysteine to methionine in a methylcobalamin-dependent reaction...
  8. ncbi 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    L D Botto
    Birth Defects and Pediatric Genetics Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 151:862-77. 2000
    ..g., cystathionine-beta-synthase and methionine synthase reductase)...
  9. ncbi Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men
    V Dekou
    Cardiovascular Genetics, Department of Medicine, University College London Medical School, The Rayne Institute, UK
    Thromb Haemost 85:67-74. 2001
    ..polymorphism in exon 8 of the cystathionine b synthase (CBS) gene and the D919G polymorphism in the methionine synthase (MS) gene. The median value for plasma homocysteine was 11.90 micromol/l (25-75% Interquartile range 10...
  10. ncbi Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    b>Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body...
  11. ncbi Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women
    M L Silaste
    Department of Internal Medicine, University of Oulu, Kajaanintie 50, FIN 90220 Oulu, Finland
    J Nutr 131:2643-7. 2001
    ..reductase (MTHFR) gene, 844ins68 of cystathionine beta-synthase (CBS) gene and A2756G mutation of methionine synthase (MS) gene were determined...
  12. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ..to investigate the interrelationships between polymorphisms in the methylenetetrahydrofolate (MTHFR C677T and A1298C) gene and other genes (MTR A2756G; MTRR A66G and CBS 844ins68), intake of B-vitamins and colorectal cancer risk (CRC).
  13. ncbi Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors
    Maria F Paz
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Research Center CNIO, 28029 Madrid, Spain
    Cancer Res 62:4519-24. 2002
    ..in three key genes involved in the metabolism of the methyl group, methylene-tetrahydrofolate reductase, methionine synthase, and cystathionine beta-synthase, and analyzed their association with DNA methylation parameters...
  14. pmc Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
    Marie Therese Doolin
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Hum Genet 71:1222-6. 2002
    ..Analysis of data on variants of two genes involved in homocysteine remethylation/methionine biosynthesis--methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G--provided evidence that both variants influence ..
  15. ncbi Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Mol Genet Metab 78:216-21. 2003
    ..The purpose of this study is to investigate whether gene polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) are involved in the risk for NTDs, specifically spina bifida...
  16. ncbi Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:157-62. 2004
    b>Methionine synthase [5-methyltetrahydrofolate-homocysteine S-methyltransferase (MTR)] is involved in folate-mediated one-carbon metabolism, a pathway known to play a role in colorectal carcinogenesis...
  17. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..genes involved in folate metabolism--methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-..
  18. ncbi Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Carcinogenesis 25:1639-47. 2004
    ..Major genes involved in folate metabolism include methylene-tetrahydrofolate reductase (MTHFR) and methionine synthase (MS)...
  19. pmc Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease
    P Bosco
    IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    J Neurol Neurosurg Psychiatry 75:1036-8. 2004
    ..Genetic polymorphisms of APO-E, homocysteine, and the IL-1 gene cluster (IL-1A, IL-1B, receptor antagonist IL-1RN) are associated with sporadic Alzheimer's disease and may involve interdependent pathways of neuronal toxicity...
  20. ncbi Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort
    Arve Ulvik
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 13:2175-80. 2004
    ..polymorphisms 677C --> T of the methylenetetrahydrofolate reductase (MTHFR) and 2756A --> G of the methionine synthase (MTR) genes and risk of colorectal cancer...
  21. ncbi [Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease]
    Yong Li
    Department of Nutrition, Peking University School of Public Health, Beijing 100083, China
    Beijing Da Xue Xue Bao 37:75-80. 2005
    ..B(12), Hcy levels and CHD...
  22. ncbi Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China
    Carcinogenesis 26:1285-90. 2005
    ..Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk...
  23. ncbi Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1188-93. 2005
    ..We hypothesized that polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) in the folate metabolic pathway are associated with SCCHN ..
  24. ncbi Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    b>Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase (MTR)...
  25. ncbi One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..this pathway, MTHFR C677T and A1298C (genes for methylenetetrahydrofolate reductase), MTR A2756G (gene for methionine synthase) and TS (gene for thymidylate synthase) tandem repeats polymorphisms, have attracted attention...
  26. ncbi Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402 Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:2509-16. 2005
    ..associations between genetic variants in the reduced folate carrier (RFC), thymidylate synthase (TS), methionine synthase (MTR), and 5,10-methylenetetrahydrofolate reductase (MTHFR) and colon cancer risk...
  27. pmc Human methionine synthase reductase is a molecular chaperone for human methionine synthase
    Kazuhiro Yamada
    4002 Life Sciences Institute, Department of Biological Chemistry, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Proc Natl Acad Sci U S A 103:9476-81. 2006
    Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins...
  28. ncbi Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss
    Menachem Gross
    Department of Otolaryngology Head and Neck Surgery, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Audiol Neurootol 11:287-93. 2006
    ..separation by electrophoresis: methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and methionine synthase (MTR) A2756G polymorphisms...
  29. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  30. ncbi [Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study]
    Kun Chen
    School of Public Health, Zhejiang University, Hangzhou 310031, China
    Zhonghua Zhong Liu Za Zhi 28:429-32. 2006
    ..To investigate the interrelationship of genetic polymorphisms in folate metabolic enzymes (MTHFRC677T, MTHFRA1298C, MTRA2756G and MTRRA66G) and their combinative effects with colorectal cancer (CRC)...
  31. ncbi Genetic polymorphisms in folate metabolism and the risk of stomach cancer
    Fang Fang Zhang
    Division of Cancer Epidemiology and Genetics, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:115-21. 2007
    ..cancer in relation to polymorphisms in folate-metabolizing genes, including MTHFR (Ex5+79C>T and Ex8-62A>C), MTR (Ex26-20A>G), and MTRR (Ex2-64A>G, Ex5+123C>T, Ex15+572C>T, Ex15-405A>T, Ex9-85C>T, Ex15-526G>..
  32. ncbi Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses
    Jolanta Lissowska
    Department of Cancer Epidemiology and Prevention, Cancer Center and M Sklodowska Curie Institute of Oncology, Warsaw, Poland
    Int J Cancer 120:2696-703. 2007
    ..Data suggested an association between a nonsynonymous change in the gene coding for methionine synthase (MTR D919G) and reduced breast cancer risk: OR (95% CI) = 0.84 (0.73-0.96) and 0.85 (0.62-1...
  33. ncbi Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    Ase Fredriksen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Hum Mutat 28:856-65. 2007
    ..665C>T (known as 677C>T; p.Ala222Val) and c.1286A>C (known as 1298A>C; p.Glu429Ala); methionine synthase (MTR) c.2756A>G (p.Asp919Gly); methionine synthase reductase (MTRR) c.66A>G (p...
  34. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..in methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS), transcobalamin II (TCNII), methionine synthase (MTR), reduced folate carrier (RFC), methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), dihydrofolate ..
  35. ncbi Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan
    Cheng Ping Yu
    Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
    Anticancer Res 27:1727-32. 2007
    ..The purpose of this study was to test the hypothesis that multigenotypic polymorphisms in the folate metabolic pathway, which may result in genomic instability and inbalance of estrogen metabolism, were associated with breast cancer risk...
  36. ncbi Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract
    N Ott
    Department of Pathology, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Germany
    J Cancer Res Clin Oncol 134:405-10. 2008
    ..b>Methionine synthase (MTR) and cystathionine ss-synthase (CBS) are enzymes that play a central role in folate metabolism, ..
  37. ncbi Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease
    Laurent Peyrin-Biroulet
    INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre les Nancy, France
    Am J Gastroenterol 103:399-406. 2008
    The aim of this study was to evaluate the association of nutritional (folate, vitamin B12) and genetic (MTHFR, MTR, MTRR, TCN) determinants of homocysteine metabolism and of superoxide dismutase with Crohn's disease (CD).
  38. doi Dietary vitamin B6 intake and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:171-82. 2008
    ..in the whole sample and after age, sex, cancer site, folate, MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), MTR A2756G (rs1805087), and MTRR A66G (rs1801394) stratification (analysis on genotypes on 1,001 cases and 1,010 ..
  39. doi Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 17:2742-7. 2008
    ..with polymorphisms in one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS) variable number of ..
  40. ncbi Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients
    Catarina Sousa Guerreiro
    Escola Superior de Tecnologia da Saúde de Lisboa, Unidade de Nutrição e Metabolismo do Instituto de Medicina Molecular da Universidade de Lisboa, Lisboa, Portugal
    Am J Clin Nutr 88:1413-8. 2008
    ..Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC)...
  41. doi Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma
    Taiki Yamaji
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Epidemiol Biomarkers Prev 18:267-74. 2009
    Genomic DNA hypomethylation has been associated with colorectal carcinogenesis. Methionine synthase A2756G (MTR A2756G) is a common nonsynonymous polymorphism in the gene that encodes methionine synthase, a key enzyme in the pathway ..
  42. doi Plasma homocysteine and gene polymorphisms associated with the risk of hyperlipidemia in northern Chinese subjects
    Lei Huang
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China
    Biomed Environ Sci 21:514-20. 2008
    To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase (MTHFR) gene and methionine synthase (MS) gene.
  43. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  44. pmc Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk
    Susan E Steck
    Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N C, USA
    J Nutrigenet Nutrigenomics 1:196-204. 2008
    ..We examined associations among folate and alcohol intake, single nucleotide polymorphisms (SNPs) in genes involved in one-carbon metabolism, and colon cancer risk...
  45. pmc Methionine synthase A2756G polymorphism and cancer risk: a meta-analysis
    Ke Yu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Eur J Hum Genet 18:370-8. 2010
    Polymorphisms in methionine synthase (MTR) gene may be involved in carcinogenesis by affecting DNA methylation. However, association studies on MTR A2756G polymorphism in cancers have reported conflicting results...
  46. doi Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 18:3086-96. 2009
    ..We studied associations of genetic variants of folate metabolizing enzymes (MTHFR, MTR, and MTRR), DNA methyltransferase DNMT3b, and histone methyltransferases (EHMT1, EHMT2, and PRDM2), with colorectal ..
  47. pmc Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 21:331-45. 2010
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer...
  48. doi Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Department of Pharmacology, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:28-38. 2010
    ..In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk...
  49. pmc Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, Section for Pharmacology, Department of Internal Medicine, University of Bergen, and Haukeland University Hospital, 5021 Laboratory Building, 9th Floor, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:1328-40. 2010
    ..We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort...
  50. pmc A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010
    ..Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer...
  51. pmc The allele frequencies of three polymorphisms in genes involved in homocysteine metabolism in a group of unrelated healthy Singaporeans
    Chuanfei Chen
    Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore
    Dis Markers 29:111-9. 2010
    The cystathionine β-synthase (CBS) 844ins68 polymorphism, methionine synthase (MS) A2756G SNP, and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T SNP are associated with homocysteine (Hcy) level in humans...
  52. doi Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma
    José Luiz Miranda Guimarães
    Service of Oncohematology, Department of Clinical Oncology from Hospital Santa Rita Complexo Hospitalar Santa Casa, Grupo Hospitalar Conceição, Rua Capitão Pedro Werlang, 614, Partenon, Porto Alegre, Rio Grande do Sul, Cep 91530110, Brazil
    Tumour Biol 32:853-61. 2011
    ..the polymorphic genotype frequencies of methylenetetrahydrofolate reductase (MTHFR A1298C and C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS 2R/3R) in 113 ..
  53. doi Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China
    Lian Hua Cui
    Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao City 266021, China
    Med Oncol 29:1837-42. 2012
    ..reductase 1298 A → C (MTHFR 1298A → C), thymidylate synthase (TYMS 3R → 2R), and methionine synthase 2756 A → G (MTR 2756 A → G) on the risk of primary liver cancer (PLC)...
  54. pmc The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer
    Daijun Zhou
    4th Team of Cadet Brigade, Third Military Medical University, Chongqing 400038, China
    Int J Biol Sci 8:819-30. 2012
    ..methylenetetrahydrofolate reductase (MTHFR) C677T and A1289C, methione synthase reductase (MTRR) A66G, methionine synthase (MTR) A2756G polymorphisms and the risk of CRC, respectively...
  55. ncbi Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event
    Zoe Yates
    Academic Unit of Paediatrics and Obstetrics and Gynaecology, D Floor, Clarendon Wing, Leeds General Infirmary, University of Leeds, Leeds, West Yorkshire LS2 9NS, UK
    Mol Genet Metab 79:201-13. 2003
    ....
  56. doi One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:356-62. 2008
    ..in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate ..
  57. pmc Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome
    N Fintelman-Rodrigues
    Departamento de Genetica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Dis Markers 26:155-61. 2009
    ..We compared the frequency of CBS 844ins68, MTR 2756A>G, RFC-1 80G&gt A and TC 776C>G polymorphisms among 114 case mothers and 110 matched controls, in ..
  58. ncbi Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma
    Lisa F Lincz
    Hunter Haematology Research Group, Newcastle Mater Misericordiae Hospital, NSW, Australia
    Br J Haematol 120:1051-4. 2003
    ..We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-..
  59. ncbi Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism
    A Wilson
    MRC Group in Medical Genetics, Montreal Children s Hospital, Canada
    Hum Mol Genet 8:2009-16. 1999
    b>Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia...
  60. ncbi Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant
    Jaimie D Vaughn
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 134:2985-90. 2004
    Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are important for homocysteine remethylation...
  61. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
    ..One such enzyme, methionine synthase reductase (MTRR), maintains adequate levels of methylcob(III)alamin, the activated cofactor for methionine ..
  62. pmc Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption
    Cande V Ananth
    Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901 1977, USA
    Mol Genet Metab 91:104-10. 2007
    b>Methionine synthase reductase (MTRR) and betaine-homocysteine S-methyltransferase (BHMT) are two enzymes that regulate homocysteine metabolism...
  63. pmc Sinorhizobium meliloti requires a cobalamin-dependent ribonucleotide reductase for symbiosis with its plant host
    Michiko E Taga
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Plant Microbe Interact 23:1643-54. 2010
    ..BhbA) does not affect symbiosis, whereas disruption of the metH gene encoding the cobalamin-dependent methionine synthase causes a significant defect in symbiosis...
  64. pmc Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli
    Elise R Hondorp
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 2:e336. 2004
    ..and the enzyme that catalyzes the final step of methionine biosynthesis, cobalamin-independent methionine synthase (MetE). We found that E...
  65. ncbi [A rare inborn error of intracellular processing of cobalamine presenting with microcephalus and megaloblastic anemia: a report of 3 children]
    P Muller
    HELIOS Krankenhaus Leisnig, Abteilung für Kinder und Jugendmedizin, Leisning
    Klin Padiatr 219:361-7. 2007
    Defects of methionine synthase or methionine synthase reductase result in an impaired remethylation of homocysteine to methionine...
  66. ncbi Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry
    Kirsten R Wolthers
    Faculty of Life Sciences, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M1 7DN, United Kingdom
    Biochemistry 46:11833-44. 2007
    Human methionine synthase reductase (MSR) is a 78 kDa flavoprotein that regenerates the active form of cobalamin-dependent methionine synthase (MS)...
  67. ncbi cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression
    Petra Zavadakova
    Institute of Inherited Metabolic Diseases, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Hum Mutat 25:239-47. 2005
    ..type of homocystinuria is a rare autosomal recessive disorder caused by impaired reductive activation of methionine synthase. Although earlier biochemical studies proposed that the methionine synthase enzyme might be activated by ..
  68. pmc Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
    D Leclerc
    Medical Research Council Group in Medical Genetics, The Montreal Children s Hospital, McGill University Health Centre, Montreal, PQ, Canada H3Z 2Z3
    Proc Natl Acad Sci U S A 95:3059-64. 1998
    b>Methionine synthase catalyzes the remethylation of homocysteine to methionine via a reaction in which methylcobalamin serves as an intermediate methyl carrier...
  69. pmc Impeded electron transfer from a pathogenic FMN domain mutant of methionine synthase reductase and its responsiveness to flavin supplementation
    Carmen G Gherasim
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 47:12515-22. 2008
    b>Methionine synthase reductase (MSR) is a diflavin oxidoreductase that transfers electrons from NADPH to oxidized cobalamin and plays a vital role in repairing inactive cobalamin-dependent methionine synthase...
  70. pmc A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution
    D M Hoover
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109, USA
    Protein Sci 6:2525-37. 1997
    ..activation of the enzymes pyruvate formate-lyase, anaerobic ribonucleotide reductase, and B12-dependent methionine synthase. As a basis for studies of the interactions of flavodoxin with methionine synthase, crystal structures of ..
  71. ncbi Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1
    Horatiu Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 278:38310-4. 2003
    b>Methionine synthase is an essential cobalamin-dependent enzyme in mammals that catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine to give tetrahydrofolate and methionine...
  72. ncbi Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase
    J T Jarrett
    Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    Biochemistry 36:15739-48. 1997
    b>Methionine synthase catalyzes the transfer of a methyl group from methylcobalamin enzyme to homocysteine, generating methionine and cob(I)alamin enzyme, and then from methyltetrahydrofolate to cob(I)alamin enzyme, generating ..
  73. ncbi The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme
    J T Jarrett
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104, USA
    Biochemistry 37:12649-58. 1998
    Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine, generating tetrahydrofolate and methionine...
  74. ncbi Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase
    Horatiu Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 41:13378-85. 2002
    b>Methionine synthase reductase (MSR) catalyzes the conversion of the inactive form of human methionine synthase to the active state of the enzyme...
  75. doi Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex
    Kirsten R Wolthers
    Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    FEBS J 276:1942-51. 2009
    Human methionine synthase reductase (MSR), a diflavin enzyme, restores the activity of human methionine synthase through reductive methylation of methionine synthase (MS)-bound cob(II)alamin...
  76. ncbi Participation of cob(I) alamin in the reaction catalyzed by methionine synthase from Escherichia coli: a steady-state and rapid reaction kinetic analysis
    R V Banerjee
    Biophysics Research Division, University of Michigan, Ann Arbor 48109
    Biochemistry 29:11101-9. 1990
    The kinetic mechanism of the reaction catalyzed by cobalamin-dependent methionine synthase from Escherichia coli K12 has been investigated by both steady-state and pre-steady-state kinetic analyses...
  77. ncbi Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase
    Horatiu Olteanu
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 43:1988-97. 2004
    Human methionine synthase reductase (MSR) is a protein containing both FAD and FMN, and it reactivates methionine synthase that has lost activity due to oxidation of cob(I)alamin to cob(II)alamin...
  78. ncbi Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles
    Elizabeth C Banks
    School of Pharmacy, University of Bradford, UK
    FEBS J 274:287-99. 2007
    The cobalamin-dependent cytosolic enzyme, methionine synthase (EC.2.1.1.13), catalyzes the remethylation of homocysteine to methionine using 5-methyltetrahydrofolate as the methyl donor...
  79. ncbi Nucleotide sequence diversity at the methionine synthase locus in endangered Dunnia sinensis (Rubiaceae): an evaluation of the positive selection hypothesis
    Yu Chung Chiang
    Department of Biology, Taiwan Normal University, Taipei, Taiwan, ROC
    Mol Biol Evol 19:1367-75. 2002
    b>Methionine synthase is a key enzyme for the synthesis of the aspartate-derived methionine, the immediate precursor of S-adenosyl-methionine, which has been illustrated to be associated with plant growth and pathogen interactions...
  80. pmc Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269
    Sha Huang
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Protein Sci 16:1588-95. 2007
    ..for Structural Genomics, revealed structural homology with the fourth module of the cobalamin-dependent methionine synthase (MetH) from Escherichia coli, despite the lack of significant sequence homology...
  81. ncbi Cobalamin-dependent methionine synthase from Escherichia coli: involvement of zinc in homocysteine activation
    C W Goulding
    Biophysics Research Division and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan, 48109 1055, USA
    Biochemistry 36:15749-57. 1997
    b>Methionine synthase (MetH) is a modular protein with at least four distinct regions; amino acids 2-353 comprise a region responsible for binding and activation of homocysteine, amino acids 345-649 are thought to be involved in the ..
  82. pmc Targeted disruption of the methionine synthase gene in mice
    D A Swanson
    Genetics and Molecular Biology Branch, Bethesda, National Human Genome Research Institute, Bethesda, Maryland 20892 4442, USA
    Mol Cell Biol 21:1058-65. 2001
    ..b>Methionine synthase, one of only two mammalian enzymes known to require vitamin B12 as a cofactor, lies at the intersection of ..
  83. ncbi MTRR 66A>G polymorphism in relation to congenital heart defects
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem Lab Med 44:1317-23. 2006
    ..The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential ..
  84. pmc Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice
    Liyuan Deng
    Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, Montreal, Canada
    Mol Genet Metab 94:336-42. 2008
    ..b>Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent ..
  85. pmc Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor
    Matthew D Liptak
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Am Chem Soc 130:16374-81. 2008
    The cobalamin-dependent methionine synthase (MetH) from Escherichia coli is a modular enzyme that catalyzes a methyl group transfer from methyltetrahydrofolate to homocysteine via a methylcob(III)alamin (MeCbl) intermediate, generating ..
  86. ncbi Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects
    L C Brody
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Mol Genet Metab 67:324-33. 1999
    ..b>Methionine synthase catalyzes the vitamin B(12)-dependent conversion of homocysteine and 5-methyltetrahydrofolate to methionine ..
  87. ncbi Polymorphic background of methionine synthase reductase modulates the phenotype of a disease-causing mutation
    Carmen Gherasim
    Redox Biology Center and Biochemistry Department, University of Nebraska Lincoln, Lincoln, Nebraska 68588 0664, USA
    Hum Mutat 28:1028-33. 2007
    b>Methionine synthase reductase (MTRR) is the locus of the cblE class of inborn errors of cobalamin metabolism that is characterized by megaloblastic anemia and homocystinuria. Two highly prevalent SNPs, c.66A>G (p.Ile22Met) and c...
  88. ncbi A synthetic module for the metH gene permits facile mutagenesis of the cobalamin-binding region of Escherichia coli methionine synthase: initial characterization of seven mutant proteins
    M Amaratunga
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109, USA
    Biochemistry 35:2453-63. 1996
    Cobalamin-dependent methionine synthase from Escherichia coli is a monomeric 136 kDa protein composed of multiple functional regions...
  89. ncbi The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease
    X L Wang
    Department of Cardiovascular Medicine, University of New South Wales, Prince Henry Prince of Wales Hospitals, Sydney, Australia
    J Cardiovasc Risk 5:289-95. 1998
    Modest elevations in levels of circulating homocysteine are common in patients with vascular disease. Methionine synthase is a vitamin B12-dependent enzyme catalysing the re-methylation of homocysteine to methionine; reduced methionine ..
  90. ncbi Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
    Kirsten R Wolthers
    Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    Biochemistry 46:6696-709. 2007
    b>Methionine synthase (MS) is a cobalamin-dependent enzyme. It transfers a methyl group from methyltetrahydrofolate to homocysteine forming methionine and tetrahydrofolate...
  91. pmc Restricted role for methionine synthase reductase defined by subcellular localization
    D S Froese
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Mol Genet Metab 94:68-77. 2008
    b>Methionine synthase reductase (MSR; gene name MTRR) is responsible for the reductive activation of methionine synthase...
  92. doi Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro
    Cai Tang
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, PR China
    Anticancer Drugs 19:697-704. 2008
    Cobalamin-dependent methionine synthase, with a cofactor of vitamin B12, catalyzes the reaction of 5-methyltetrahydrofolate and homocysteine to form methionine and tetrahydrofolate, which takes a core position in folate cycle, one-carbon-..
  93. doi A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 19:325-9. 2009
    Oxidation of vitamin B12 by nitrous oxide leads to the inactivation of methionine synthase resulting in elevated plasma total homocysteine concentrations...
  94. pmc Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase
    C Lee Elmore
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Mol Genet Metab 91:85-97. 2007
    ..In humans, methionine synthase deficiency results in the accumulation of methyltetrahydrofolate at the expense of folate derivatives ..
  95. ncbi Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats
    Deborah J Culley
    Department of Anesthesiology Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesth Analg 105:83-8. 2007
    Nitrous oxide is a commonly used anesthetic that inhibits the activity of methionine synthase, an enzyme involved in methylation reactions and DNA synthesis and repair...
  96. pmc The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target
    Huda S Suliman
    Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Arch Biochem Biophys 467:218-26. 2007
    b>Methionine synthase catalyzes the transfer of a methyl group from tetrahydrofolate to homocysteine to produce methionine. Although mammalian enzymes are cobalamin-dependent, fungal methionine synthases are cobalamin-independent...
  97. ncbi Identification of the cobalamin-dependent methionine synthase gene, metH, in Vibrio fischeri ATCC 7744 by sequencing using genomic DNA as a template
    S Kasai
    Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, Sugimoto 3 3 138, Sumiyoshi ku, Osaka 558 8585, Japan
    Gene 264:281-8. 2001
    To confirm the presence of cobalamin-dependent methionine synthase (CDMS) in luminous bacteria, which is a prerequisite for the substantiation of our proposals on the physiological function of the lux operon, we identified the CDMS gene (..
  98. pmc Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
    Robert Pejchal
    Department of Biological Chemistry, University of Michigan, Ann Arbor, USA
    PLoS Biol 3:e31. 2005
    Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier...
  99. ncbi [Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase, methionine synthase and the risk of pancreatic cancer]
    Li Wang
    Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
    Zhonghua Liu Xing Bing Xue Za Zhi 27:50-4. 2006
    To determine whether genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G) were associated with the risks of pancreatic cancer.
  100. pmc Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase
    Matthew D Liptak
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biochemistry 46:8024-35. 2007
    Cobalamin-dependent methionine synthase (MetH) of Escherichia coli is a 136 kDa, modular enzyme that undergoes large conformational changes as it uses a cobalamin cofactor as a donor or acceptor in three separate methyl transfer ..
  101. pmc MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Mol Med 16:425-32. 2010
    ..line polymorphisms in the folate- and methyl-associated genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR) and methionine synthase reductase (MTRR), were analyzed in the same patient cohort to find a possible ..

Research Grants63

  1. GENETIC RISK FACTORS FOR HYPERHOMOCYSTEINEMIA
    ROY GRAVEL; Fiscal Year: 2006
    ..A major outcome was the discovery of a novel enzyme methionine synthase reductase (gene and enzyme symbol, MTRR) required for the activation of cobalamin-dependent methionine ..
  2. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..within the aging CNS damage key enzymes of the folate pathway, particularly the vitamin B12-dependent methionine synthase (MS), contributing to neurological disease...
  3. Sylvia B Smith; Fiscal Year: 2016
    ..to genetic defects involving cystathionine synthase (CBS), methylenetetrahydrofolate reductase (MTHFR) or methionine synthase as well as vitamin deficiencies (folate/B12/B6)...
  4. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..Cbl requirement for the methionine synthase enzyme in the recycling of folate results in defective DNA synthesis and the anemia...
  5. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MARK STEEN; Fiscal Year: 2001
    ..is metabolized in two pathways, transulfuration by cystathionine beta-synthase (CBS) and remethylation by methionine synthase (MS)...
  6. RUMA V BANERJEE; Fiscal Year: 2016
    ..intercompartmental escort service for reaching a rare and reactive cofactor to its target enzymes, methionine synthase and methylmalonyl-CoA mutase...
  7. Structural Characterizations of Transient and Heterogeneous Protein Complexes
    Nozomi Ando; Fiscal Year: 2013
    ..The vitamin B12-dependent methionine synthase and class Ia ribonucleotide reductases are two enzymes that epitomize such systems where structural insight ..
  8. Folic Acid Enhances Repair Mechanism in the Adult CNS
    Bermans J Iskandar; Fiscal Year: 2010
    ..2) To test whether methionine synthase activity is essential in providing the molecules necessary for CNS repair (methylation)...
  9. GENETIC HETEROGENEITY IN HOMOCYSTEINE REMETHYLATION
    Barry Shane; Fiscal Year: 2000
    ..of plasma homocysteine and those at the lower end of the normal range will be ascertained for the human methionine synthase (MS), methylenetetra-hydrofolate reductase (MTHFR), cytosolic and mitochondrial serine ..
  10. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..BHMT catalyzes transfer of a methyl group from betaine to homocysteine to form methionine. BHMT and methionine synthase contribute equally to methionine formation from homocysteine in rat liver...
  11. Homocysteine and Alcoholic Liver Disease
    DONALD WELDON JACOBSEN; Fiscal Year: 2010
    ..This proposal will provide novel information on the role of methionine synthase (MS) in alcohol-associated hyperhomocysteinemia, homocysteine-induced oxidative and endoplasmic reticulum (..
  12. STRUCTURAL BASIS OF VITAMIN B12 (COBALAMIN) DEFICIENCY
    Heidi Schubert; Fiscal Year: 2002
    ..further modification before adopting an active cofactor structure required for two enzymes, cytoplasmic methionine synthase (methyl-B12) and mitochondrial methylmalonyl CoA mutase (5'-deoxyadenosyl-B12)...
  13. TIME RESOLVED STUDIES OF B12 ENZYMES AN COENZYMES
    ROSEANNE SENSION; Fiscal Year: 2000
    ..as a coenzyme for adenosylcobalamin dependent methylmalonyl-CoA mutase and methylcobalamin dependent methionine synthase. In addition to the B12-dependent enzymes there are a number of B12 transport proteins involved in the ..
  14. Vascular Biochemistry of Vitamin B12
    DONALD JACOBSEN; Fiscal Year: 2006
    ..and 3) the conversion of Cbl vitamers to methylcobalamin and adenosylcobalamin, coenzymes for cytosolic methionine synthase and mitochondrial methylmalonyI-CoA mutase, respectively...
  15. Conversion of Inactive Cobalamins to Coenzyme B12
    Thomas Bobik; Fiscal Year: 2005
    ..Preliminary studies showed that the human methionine synthase reductase can reduce cob(II)alamin to cob(I)alamin for coenzyme B 12 synthesis, and results indicated a ..
  16. FOLATE PATHWAY POLYMORPHISMS AND PANCREATIC CANCER RISK
    Michael Goggins; Fiscal Year: 2002
    ..and functionally significant polymorphisms in the methylene tetrahydrofolate reductase gene (MTHFR) and methionine synthase are associated with a reduced risk of several cancers...
  17. REGULATION TO FOLATE METABOLISM
    ROWENA MATTHEWS; Fiscal Year: 2000
    ..This research will emphasize mechanistic studies of two enzymes, cobalamin-dependent methionine synthase and serine hydroxymethyltransferase, that are potential targets for cancer chemotherapy, but for which no ..
  18. MECHANISTIC STUDY OF B12-DEPENDENT METHIONINE SYNTHASE
    Vahe Bandarian; Fiscal Year: 2001
    b>Methionine synthase (MetH) catalyzes the conversion of homocysteine to methionine, using a methyl group that is derived from methyltetrahydrofolate. B12 serves as an intermediate methyl group carrier...
  19. FOLIC ACID REQUIREMENTS AND ONE CARBON METABOLISM
    Barry Shane; Fiscal Year: 2004
    ..forms of serine hydroxymethyltransferase; (3) to study the heterozygous disruption of the mouse methionine synthase gene and other genes for folate-dependent enzymes on the flux of 1-C units through the various metabolic ..
  20. Kinetic Analysis of Methionine Synthase Reductase
    KIRSTEN WOLTHERS; Fiscal Year: 2004
    The objectives of the proposed research are to understand the enzymology of human methionine synthase (MS) and methionine synthase reductase (MSR) as well as their clinically relevant variants...
  21. Pharmacogenetics of Methotrexate Therapy in Arthritis
    ALEXANDER WHITEHEAD; Fiscal Year: 2006
    ..In addition, methionine synthase (MTR), cystathionine Beta-synthase (CBS), and methionine synthase reductase (MTRR) are involved in ..
  22. RAPID KINETIC AND OTHER STUDIES OF BIOLOGICAL OXYGENASES
    David Ballou; Fiscal Year: 2002
    ..The reactions involve methyl transfers to and from cobalamin, very similar to those we have measured with methionine synthase. 4) Galactose oxidase, a copper containing enzyme with an unusual tyrosine radical...
  23. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..of interest includes: serine hydroxymethyltransferase (SHMT1), mehylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), thymidylate synthase (TYMS or TS), S-adenosylhomocysteine ..
  24. Genetics of Prostate Cancer Risk & Agressiveness
    Graham Casey; Fiscal Year: 2007
    ..factor signaling (IGFBP-3), 3) folate metabolism (5,10- Methylene-tetrahydrofolate reductase (MTHFR) and Methionine Synthase (MTR)), and 4) steroid hormone metabolism (CYP3A7)...
  25. Methylation and Oxidation in Breast Cancer Epidemiology
    Jo Freudenheim; Fiscal Year: 2005
    ..variation in enzymes important in one-carbon metabolism (methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MS) and cystathione B-synthase (CBS)) in relation to risk and to investigate interaction of these genetic ..
  26. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
    ..of folic acid in individuals with respect to two variants of MTHFR (C677T & A1298C), MS A2756G, and methionine synthase reductase (MTRR) A66G...
  27. Conformational changes of the multi-modular MetH
    ALLISON LAMANNA; Fiscal Year: 2007
    ..The conformational changes of the enzyme cobalamin-dependent methionine synthase (MetH) can be studyied by labeling its 5 domains with different fluorophores to measure the interactions ..
  28. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..the 677C yields T and 1298A yields C polymorphisms in 5,10- methylenetetrahydrofolate Reductase (MTHFR), methionine synthase reductase (MTRR) 66A yields G polymorphism, betaine-homocysteine methyltransferase (BHMT) mutation and ..
  29. Benjamin Ping Chi Chen; Fiscal Year: 2016
    ..congenita (DC) syndrome and in mice double knockout of protection of telomeres 1b (POT1b) and telomerase RNA (mTR) genes. In addition, DC patients are also prone to cancer development...
  30. KELLY ANN DOUGHERTY; Fiscal Year: 2014
    ..knowledge that she obtained during her postdoctoral fellowship and UPenn Masters in Translational Research (MTR) thesis work and to prepare her for future R01 submissions to conduct nutrition intervention studies in children ..
  31. Helen M Blau; Fiscal Year: 2016
    ..short telomeres to DMD when we recently showed that mice with mutant dystrophin and shortened telomeres (our mdx/mTR mice) faithfully recapitulate human DMD, unlike mice with mutant dystrophin alone (Cell, 2010)...
  32. Telomeres and Telomerase in Stem Cell Failure and Aging
    Carol W Greider; Fiscal Year: 2010
    ..We have generated a line of telomerase RNA null (mTR-/-) mice on the CAST/EiJ genetic background that has short telomeres, similar to telomere length in humans...
  33. Tammy A Morrish; Fiscal Year: 2015
    ..In order to study these non- telomerase telomere maintenance mechanisms we are using E[unreadable]myc+mTR-/- mice, genetically deleted for the RNA component of telomerase (mTR), and crossed to E[unreadable]myc+ mice, ..
  34. Mechanisms of subtelomere recombination in telomerase deficient tumors
    Tammy A Morrish; Fiscal Year: 2012
    ..In order to study these non- telomerase telomere maintenance mechanisms we are using E5myc+mTR-/- mice, genetically deleted for the RNA component of telomerase (mTR), and crossed to E5myc+ mice, which develop B-..
  35. TRAINING PROGRAM IN CANCER PHARMACOLOGY
    IAN ALEXANDER BLAIR; Fiscal Year: 2013
    ..The Master's program in Translational Research (MTR) and new clinical leadership provided by Dr...
  36. Gianluca Tosini; Fiscal Year: 2015
    ..In the present application we will further investigate the effect of MTR removal on the retina by using melatonin proficient mice (C3H-f+/+) mouse in which the two different types of g- ..
  37. Ponnada A Narayana; Fiscal Year: 2016
    ..Automated Processing);MRS (magnetic resonance spectroscopy);MS (multiple sclerosis);MSFC (MS functional composite);MTR (magnetization transfer ratio);NABT (normal appearing brain tissue);NAWM (normal appearing white matter);PD (proton ..
  38. Carol W Greider; Fiscal Year: 2015
    ..We will take advantage of the powerful E-mu-myc mTR-/- G5 mice that we developed in the previous period with funding from the NCI PPG...
  39. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2011
    ..In the present application we will further investigate the effect of MTR removal on the retina by using melatonin proficient mice (C3H-f+/+) mouse in which the two different types of ..
  40. Dost Ongur; Fiscal Year: 2015
    ..will implement 2 such techniques (diffusion tensor spectroscopy or DTS, and magnetization transfer ratio or MTR) at 4 Tesla and collect data from a 9cc pure white matter voxel in the right prefrontal cortex in patients with ..
  41. Role of microRNAs in malignant progression
    Li Ma; Fiscal Year: 2012
    ..therapies In mice;I will establish a genetically engineered mouse model to determine the role and mechanisms of mtR-10b In normal development and In metastatic progression of spontaneous breast cancer;and I will explore the cell ..
  42. ATTENUATION CONTROL OF GENE EXPRESSION IN BACTERIA
    Charles Yanofsky; Fiscal Year: 1999
    ..Studies on attenuation in the trp operon of Bacilli will concentrate on characterizing the regulatory gene, mtr, and its polypeptide product...
  43. MAMMOGRAPHY TUMOR REGISTRY FOR BREAST CANCER RESEARCH
    Nicole Urban; Fiscal Year: 2000
    Continued expansion and enhancement of the Mammography Tumor Registry (MTR) in Washington State is proposed in order to build a foundation for collaborative interdisciplinary research on mammography performance in a community setting...
  44. MR of post traumatic axonal de- and regeneration
    David Hackney; Fiscal Year: 2005
    ..The magnetization transfer ratio (MTR) is a function of the interaction of water with macromolecules...
  45. NEW TUMOR MODELS FOR THE DEVELOPMENT OF IMMUNOTHERAPY
    Ralph Reisfeld; Fiscal Year: 1992
    ..monoclonal antibodies (chMabs) against receptors for epidermal growth factor (EGF-R) and melanotransferrin (MTr); novel chimeric antibody-interleukin-2 and tumor necrosis factor fusion proteins, bispecific antibodies ..
  46. ANNUAL MRI, MTR AND HMRSI IN HEALTHY CONTROLS AND PPMS
    Stephen Hauser; Fiscal Year: 2001
    ..Abstract): The overall goals of this study are: (1) to define the natural history of quantitative MRI and brainwide MTR and HMRSI in patients with primary progressive (PP)MS and healthy controls and, (2)determine the treatment effect ..
  47. Investigation of xrcc5 Mutant Mice
    EDWARD HASTY; Fiscal Year: 2005
    ..To investigate the impact of telomere maintenance, ku80-/- mTR-/- mice will be investigated...
  48. Genetic Profiles for Perioperative Applications
    ROBERT KWIATKOWSKI; Fiscal Year: 2001
    ..to neuromuscular blocking agents (BChE, RYR1, CACNA1S), opioids and antiarrythmics (CYP2D6), nitrous oxide (MTHFR, MTR, MTRR, CBS), volatile anesthetics (RYR1, CACNA1s), and the risk and severity of sepsis (TNF-alpha, TNF-beta), and ..
  49. Neurological Indices of CNS Involvement in "Non-CNS" SLE
    JANET SHUCARD; Fiscal Year: 2009
    ..MRI measures will focus on magnetization transfer ratio (MTR) to quantify tissue loss and microscopic tissue injury...
  50. HERPESVIRUS EXPRESSION IN TRANSFORMATION AND LATENCY
    DENISE GALLOWAY; Fiscal Year: 1991
    ..Previous studies have localized the morphological transforming region (mtr) to 792bp segment within the Bg1II N fragment...
  51. CYTOMEGALOVIRUS AND HUMAN MALIGNANCY
    Eng Shang Huang; Fiscal Year: 1992
    ..The hypothesis of this study is that the DNA of CMV morphological transforming region (mtr) alone is not sufficient to initiate the transformation of human cells...
  52. Remediation of Reading Problems in Children
    TERI LAWTON; Fiscal Year: 2002
    PDI intends to complete the clinical validation and product development for a software program, MovingToRead (MTR), which has been found to significantly improve reading fluency by practicing a 10-minute computer game...
  53. Non-invasive evaluation of tissue engineered bone impla*
    Kimberlee Potter; Fiscal Year: 2003
    ..proton longitudinal (T1) and transverse (T2) relaxation times and the water proton magnetization transfer ratio (MTR) of the bone produced within this tissue model...
  54. QUANTITATIVE MR IMAGING AND PROTON SPECTROSCOPY IN MS
    Robert Grossman; Fiscal Year: 2005
    ..quantitation of brain parenchyma and the gray and white matter components of parenchyma, analysis of the MTR histogram, and measurement of WBNAA will be utilized to estimate neuronal loss...
  55. 14th International Congress on Flavins and Flavoproteins
    ROWENA MATTHEWS; Fiscal Year: 2002
    ..Tea will be served at each poster session. Presentations were selected by an International Organizing Committee with an eye to a diverse representation of speakers at the meeting. ..
  56. REGULATION OF FOLATE METABOLISM
    ROWENA MATTHEWS; Fiscal Year: 2008
    ..of two enzymes that catalyze the final step in methionine biosynthesis/regeneration, cobalamin-dependent methionine synthase (MetH) and cobalaminindependent methionine synthase (MetE)...
  57. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..abstract_text> ..
  58. 2009 Multi-drug Efflux Systems Gordon Research Conference
    William Shafer; Fiscal Year: 2008
    ..The GRC will focus on these specific key areas related to multi-drug efflux pumps in resistance. [unreadable] [unreadable] [unreadable]..
  59. GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINS
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  60. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
  61. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  62. Sexually Transmitted Infections & Antimicrobial Peptides
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..