mTOR

Summary

Gene Symbol: mTOR
Description: mechanistic target of rapamycin
Alias: FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, serine/threonine-protein kinase mTOR, FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein 1, mammalian target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, rapamycin target protein 1
Species: human

Top Publications

  1. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
  2. ncbi Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    Estela Jacinto
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 6:1122-8. 2004
  3. ncbi Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    D D Sarbassov
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Curr Biol 14:1296-302. 2004
  4. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
  5. ncbi Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    Robbie Loewith
    Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Cell 10:457-68. 2002
  6. ncbi mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    Maria A Frias
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 16:1865-70. 2006
  7. ncbi SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    Estela Jacinto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 127:125-37. 2006
  8. pmc RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    P E Burnett
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1432-7. 1998
  9. pmc Common corruption of the mTOR signaling network in human tumors
    S Menon
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Oncogene 27:S43-51. 2008
  10. ncbi The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003

Research Grants

  1. The mTOR pathway in neuronal death and epileptogenesis
    Yunfei Huang; Fiscal Year: 2011
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  4. Xinjun Zhu; Fiscal Year: 2014
  5. Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2011
  6. Solving the elusive mechanism of rapamycin action in lymphocytes
    David A Fruman; Fiscal Year: 2013
  7. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
  8. Targeting Wnt and mTOR to expand hematopoietic stem cells
    Peter S Klein; Fiscal Year: 2012
  9. C Edward Rose; Fiscal Year: 2015
  10. ALOKE VIRMANI FINN; Fiscal Year: 2014

Detail Information

Publications338 found, 100 shown here

  1. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector...
  2. ncbi Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    Estela Jacinto
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 6:1122-8. 2004
    ..Here, we report that a mammalian counterpart of TORC2 (mTORC2) also exists. mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor...
  3. ncbi Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    D D Sarbassov
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Curr Biol 14:1296-302. 2004
    The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby cells accumulate mass and increase in size...
  4. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
    ..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb.
  5. ncbi Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    Robbie Loewith
    Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Cell 10:457-68. 2002
    ..Thus, the distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling. TORC1 and possibly TORC2 are conserved from yeast to man...
  6. ncbi mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    Maria A Frias
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 16:1865-70. 2006
    The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that participates in at least two distinct multiprotein complexes, mTORC1 and mTORC2 ...
  7. ncbi SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    Estela Jacinto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 127:125-37. 2006
    b>Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) protein complexes...
  8. pmc RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    P E Burnett
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1432-7. 1998
    The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive target and a member of the ataxia telangiectasia mutated (ATM)-related family of kinases that share ..
  9. pmc Common corruption of the mTOR signaling network in human tumors
    S Menon
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Oncogene 27:S43-51. 2008
    The mammalian target of rapamycin (mTOR) is responsive to numerous extracellular and intracellular cues and, through the formation of two physically and functionally distinct complexes, has a central role in the homeostatic control of ..
  10. ncbi The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
    The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding ..
  11. pmc Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
    T Sato
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
    Oncogene 29:2746-52. 2010
    b>Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported...
  12. ncbi A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    Rebecca A Bachmann
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    J Biol Chem 281:7357-63. 2006
    The mammalian target of rapamycin (mTOR) regulates nutrient-dependent cell growth and proliferation through cytoplasmic targets, such as S6 kinase 1 (S6K1)...
  13. pmc Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    Christine C Hudson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:7004-14. 2002
    ..Recent studies suggest that amplified signaling through phosphoinositide 3-kinase, and its downstream target, mTOR, enhances HIF-1-dependent gene expression in certain cell types...
  14. pmc Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy
    Michelle A T Hildebrandt
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 27:857-71. 2009
    ..PI3K), phosphatase and tensin homolog (PTEN), v-akt murine thymoma viral oncogene homolog (AKT), and mammalian target of rapamycin (mTOR) signaling pathway has been implicated in resistance to several chemotherapeutic agents...
  15. doi The evolution of the TOR pathway and its role in cancer
    E M Beauchamp
    Robert H Lurie Comprehensive Cancer Center, Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Oncogene 32:3923-32. 2013
    ..Mammalian TOR (mTOR) is very important for development in embryos, while in adult organisms it is linked to aging and lifespan effects...
  16. pmc The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53
    Soyeon Shin
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Biomed Res Int 2013:568671. 2013
    ..Further, DHA reduced the levels of phospho-Akt and phospho-mTOR in a concentration-dependent manner, while NAC almost completely blocked that effect...
  17. ncbi Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support
    F E Bertrand
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, 600 Moye Boulevard, Greenville, NC 27858, USA
    Leukemia 19:98-102. 2005
    ..cell-dependent pre-B-ALL cell line, BLIN-2, to investigate the role of the MAP kinase, PI3K/Akt, JAK/STAT and mTOR pathways in the promotion of leukemic cell growth in the presence of stromal cell support...
  18. pmc mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
    Daniel Smrz
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Blood 118:6803-13. 2011
    ..We found that mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) are up-regulated in neoplastic and developing immature mast cells ..
  19. pmc Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:311-5. 2013
    ..primarily sensed by the forkhead box transcription factor O1 (FoxO1) and the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1)...
  20. doi Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine
    Antonella Perotti
    Montabone Unit for New Drug Development, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto dei Tumori di Milano, Milano, Italy
    J Clin Oncol 28:4554-61. 2010
    ..in tumor models and widespread applicability of fluoropyrimidines in solid tumors prompted the study of the combination of the mammalian target of rapamycin (mTOR) inhibitor, non-prodrug rapamycin analog ridaforolimus, with capecitabine.
  21. ncbi Expression of mTOR signaling pathway markers in prostate cancer progression
    Celeste L Kremer
    Arizona Cancer Center, University of Arizona, 1525 N Campbell Avenue, Tucson, AZ 85724, USA
    Prostate 66:1203-12. 2006
    ..A preliminary investigation of immuno-histochemical expression of mammalian target of rapamycin (mTOR) pathway markers was undertaken to identify patterns of expression in prostate tissue.
  22. ncbi Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    Emilie Vander Haar
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nat Cell Biol 9:316-23. 2007
    ..and cell growth by activation of the protein kinases Akt (also known as protein kinase B, PKB) and mammalian target of rapamycin (mTOR)...
  23. pmc Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    Fanny Pilot-Storck
    UMR5239 Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Cell Proteomics 9:1578-93. 2010
    The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors...
  24. pmc Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1
    Dave Bridges
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 23:2955-62. 2012
    ..Furthermore, the mTORC1 component Raptor directly interacts with PI(3,5)P(2). Together these results suggest that PI(3,5)P(2) is an essential mTORC1 regulator that defines the localization of the complex...
  25. pmc Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival
    Y Wang
    School of Medicine, University of California Davis, Sacramento, CA, USA
    Oncogene 27:7106-17. 2008
    The mTOR (mammalian target of rapamycin) inhibitor rapamycin caused growth arrest in both androgen-dependent and androgen-independent prostate cancer cells; however, long-term treatment induced resistance to the drug...
  26. pmc cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
    Ewan M Smith
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 27:1005-16. 2008
    ..starvation decreases cdc2's activity against eEF2K, whereas loss of TSC2 (a negative regulator of mammalian target of rapamycin complex 1(mTORC1)) increases it...
  27. ncbi Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    J Choi
    Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853 1301, USA
    Science 273:239-42. 1996
    ..agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin-associated protein (FRAP)...
  28. doi The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma
    Ledu Zhou
    General Surgery Department of XiangYa Hosptial, Central South University, Changsha, Hunan 410078, China
    Med Oncol 27:255-61. 2010
    The mammalian target of rapamycin (mTOR) pathway, an important regulator of multiple cellular functions including proliferation, differentiation, tumorigenesis, and apoptosis, is up-regulated in many cancers...
  29. pmc Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Biochem J 421:29-42. 2009
    mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 ..
  30. pmc Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 31:1604-11. 2010
    ..evaluate genetic variation in nine genes in a candidate pathway as follows: STK11 (3 tagSNPs), PTEN (9 tagSNPs), FRAP1 (mTOR) (4 tagSNPs), TSC1 (14 tagSNPs), TSC2 (8 tagSNPs), Akt1 (2 tagSNPs), PIK3CA (7 tagSNPs), PRKAA1 (13 tagSNPs) ..
  31. pmc The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
    Lioubov G Korotchkina
    Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3 312, Buffalo, NY 14263, USA
    Aging (Albany NY) 2:344-52. 2010
    ..Noteworthy, in these cells nutlin-3a inhibited the mTOR (mammalian Target of Rapamycin) pathway, which is known to be involved in the senescence program...
  32. ncbi The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3
    C Stover
    Department of Microbiology and Immunology, University of Leicester, Leicester, UK
    Genes Immun 2:119-27. 2001
    ....
  33. doi Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer
    Jae Hong No
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Gynecol Oncol 121:8-12. 2011
    Activation of the mammalian target of rapamycin (mTOR) pathway enhances cell survival and growth by regulating the efficiency of protein translation...
  34. pmc Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response
    Huizhi Wang
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 186:5217-26. 2011
    The PI3K pathway and its regulation of mammalian target of rapamycin complex 1 (mTORC1) and glycogen synthase kinase 3 (GSK3) play pivotal roles in controlling inflammation...
  35. doi Phosphorylated mammalian target of rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell carcinoma
    Shau Hsuan Li
    Department of Hematology Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
    J Thorac Cardiovasc Surg 144:1352-9, 1359.e1. 2012
    The mammalian target of rapamycin signaling pathway has been implicated in therapeutic resistance in several types of cancer...
  36. doi A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma
    Penelope Korkolopoulou
    First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece
    BJU Int 110:E1237-48. 2012
    ..known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results...
  37. doi Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations
    Mei ling Zhu
    Cancer Institute, Fudan University Shanghai Cancer Center, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    J Thorac Oncol 8:788-95. 2013
    b>Mammalian target of rapamycin complex 1 (mTORC1) is an evolutionary conserved multiprotein complex that functions as a key regulator of gene transcription, protein translation, and autophagy...
  38. pmc A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population
    Ming Xu
    Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e60080. 2013
    As an imperative part of PI3K/Akt/mTOR pathway, mammalian target of rapamycin (mTOR) has been demonstrated to increase in gastric cancer cells and tumors...
  39. doi Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells
    Carolina Pola
    Department of Microbiology and Radiation Oncology, and NYU Cancer Institute, New York University School of Medicine, New York, New York, USA
    Cancer Res 73:4571-8. 2013
    ..integrin αvβ3, when engaging the extracellular matrix (ECM) protein vitronectin, strongly upregulate both mTOR activity and cap-dependent mRNA translation, which overrides their inhibition by hypoxia and facilitates tumor cell ..
  40. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
    ..Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion...
  41. doi Activity and complexes of mTOR in diffuse large B-cell lymphomas--a tissue microarray study
    Anna Sebestyen
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Mod Pathol 25:1623-8. 2012
    ..Targeting mTOR (mammalian target of rapamycin) offers a new approach to improve the treatment...
  42. pmc A functional variant in the MTOR promoter modulates its expression and is associated with renal cell cancer risk
    Qiang Cao
    State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e50302. 2012
    The mTOR signaling pathway plays a crucial role in the carcinogenesis of renal cell cancer (RCC). We sought to investigate the influence of genetic variations in the mTOR pathway-related genes on the risk of RCC.
  43. pmc Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    Diane C Fingar
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1472-87. 2002
    ..cell cycle progression are separable processes in mammalian cells and that growth to appropriate cell size requires mTOR- and PI3K-dependent signals...
  44. doi mTOR phosphorylated at S2448 binds to raptor and rictor
    M Rosner
    Medical Genetics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Amino Acids 38:223-8. 2010
    In mammalian cells, the mammalian target of rapamycin (mTOR) forms an enzyme complex with raptor (together with other proteins) named mTOR complex 1 (mTORC1), of which a major target is the p70 ribosomal protein S6 kinase (p70S6K)...
  45. doi Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: a verification study
    K Gately
    Thoracic Oncology Research Group, Institute of Molecular Medicine, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Lung Cancer 75:217-22. 2012
    A recent study by Dhillon et al. [12], identified both angioinvasion and mTOR as prognostic biomarkers for poor survival in early stage NSCLC...
  46. ncbi Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    Ryan J O Dowling
    Department of Biochemistry, McGill Cancer Centre, Montreal, Quebec, Canada
    Cancer Res 67:10804-12. 2007
    ..The decrease in translation caused by metformin was associated with mammalian target of rapamycin (mTOR) inhibition, and a decrease in the phosphorylation of S6 kinase, ribosomal protein S6, and eIF4E-..
  47. doi Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor
    Aranapakam M Venkatesan
    Chemical Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 53:2636-45. 2010
    ..of bis(morpholino-1,3,5-triazine) derivatives were prepared and optimized to provide the highly efficacious PI3K/mTOR inhibitor 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)..
  48. pmc Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
    Theocharis Panaretakis
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Hospital and Institute, S 171 76 Stockholm, Sweden
    Mol Biol Cell 19:41-50. 2008
    ..cell death induced by IFNalpha, at a step downstream of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Furthermore, the activation of JNK was found to occur in a PKCdelta/ERK-dependent manner...
  49. doi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
    ..We established the fact that AMPK is activated upon glycolysis block resulting in mammalian target of rapamycin (mTOR) inhibition leading to Mcl-1 decrease, but no other Bcl-2 anti-apoptotic members...
  50. ncbi Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
    C J Sabers
    Department of Pharmacology, Mayo Clinic, Rochester, Minnesota 55905
    J Biol Chem 270:815-22. 1995
    ..S-transferase (GST)-FKBP12-rapamycin affinity matrix to isolate putative mammalian targets of rapamycin (mTOR) from tissue extracts...
  51. ncbi AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
    Ling Zhi Liu
    Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 67:6325-32. 2007
    ..that AKT1 induced lung cancer cells to become resistant to CDDP through the mammalian target of the rapamycin (mTOR) signaling pathway...
  52. pmc Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
    Henna Heinonen
    Institute of Biomedicine and Biomedicum Biochip Center, Genome Scale Biology Research Program, University of Helsinki, Finland
    BMC Genomics 9:348. 2008
    ..p70S6K is a serine/threonine kinase regulated by PI3K/mTOR pathway, which plays a crucial role in control of cell cycle, growth and survival...
  53. pmc TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2
    Jeremy Copp
    Molecular and Cell Biology Laboratory and Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cancer Res 69:1821-7. 2009
    The mammalian target of rapamycin (mTOR) serine/threonine kinase is the catalytic component of two evolutionarily conserved signaling complexes. mTOR signaling complex 1 (mTORC1) is a key regulator of growth factor and nutrient signaling...
  54. ncbi Rheb binds and regulates the mTOR kinase
    Xiaomeng Long
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 15:702-13. 2005
    ..The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo...
  55. pmc Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    Alfredo Toschi
    Department of Biological Sciences, Hunter College, The City University of New York, New York, New York 10021, USA
    J Biol Chem 283:34495-9. 2008
    ..Expression of HIF1 alpha is dependent on the mammalian target of rapamycin (mTOR) and is sensitive to rapamycin...
  56. pmc The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase
    Jae H Choi
    Myriad Proteonomics, Inc, Salt Lake City, UT 84116, USA
    EMBO Rep 3:988-94. 2002
    ..In this study, we show that FKBP12-rapamycin-associated protein (FRAP, also called mTOR/RAFT) interacts with CLIP-170...
  57. ncbi Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization
    P A Moore
    Human Genome Sciences, Rockville, Maryland 20850 3331, USA
    Genomics 33:331-2. 1996
  58. ncbi Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Biol Chem 280:22473-81. 2005
    ..indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway, activation of hypoxia inducible factor (HIF) 1alpha, and ultimately HIF-1-..
  59. doi Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    J Cancer Res Clin Oncol 135:933-41. 2009
    ..adenocarcinoma, due to a frequent activation of PI3 K/AKT has been proposed as a candidate neoplasm for the treatment with mTOR inhibitors. Yet, data on the expression of mTOR cascade components in endometrial cancer are lacking.
  60. pmc A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
    Greg M Findlay
    Institute of Cancer Research, Cancer Research U K Centre of Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, U K
    Biochem J 403:13-20. 2007
    The mTOR (mammalian target of rapamycin) signalling pathway is a key regulator of cell growth and is controlled by growth factors and nutrients such as amino acids...
  61. ncbi Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation
    Yinong Wang
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circ Res 101:560-9. 2007
    ..Signaling by the mammalian target of rapamycin raptor complex, known as mTORC1, is associated with cell growth and is active within arteriosclerotic ..
  62. pmc CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1
    Thomas T Murooka
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 111:4892-901. 2008
    ..Using rapamycin, an inhibitor of mTOR, our data show the importance of mTOR in CCL5-mediated T-cell migration...
  63. ncbi GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    Do Hyung Kim
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, 02142, USA
    Mol Cell 11:895-904. 2003
    b>mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors...
  64. doi The expression of mammalian target of rapamycin in Ishikawa and HEC-1A cells
    Xiaomao Li
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:340-2. 2008
    The activation of mammalian target of rapamycin (mTOR) signaling pathway in endometrial carcinoma cells Ishikawa and HEC-1A was investigated...
  65. ncbi 2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5'-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways
    Chien Ming Li
    GTx Inc, Memphis, TN 38163, USA
    Int J Oncol 37:1023-30. 2010
    ..Taken together; these results suggest that ATCAA-10 modulates the activity of two signaling pathways, PI3K/AKT/mTOR and AMPK/mTOR, resulting in the inhibition of cancer cell growth.
  66. doi Adiponectin inhibits PDGF-induced mesangial cell proliferation: regulation of mammalian target of rapamycin-mediated survival pathway by adenosine 5-monophosphate-activated protein kinase
    Y X Su
    Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Horm Metab Res 44:21-7. 2012
    ..Adiponectin alone had no effect on HMC proliferation. The mammalian target of rapamycin (mTOR) and 40 S ribosomal S6 kinase 1 (S6K1) were activated by PDGF stimulation in HMCs...
  67. ncbi Characterization of ubiquilin 1, an mTOR-interacting protein
    Shilan Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02135, USA
    Biochim Biophys Acta 1542:41-56. 2002
    The mTOR protein kinase is known to control cell cycle progression and cell growth through regulation of translation, transcription, membrane traffic and protein degradation...
  68. doi A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
    Boris Shor
    Discovery Oncology, Wyeth Research, Pearl River, NY 10965, USA
    Cancer Res 68:2934-43. 2008
    The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus) is a recently Food and Drug Administration-approved anticancer drug with efficacy in certain solid tumors and hematologic malignancies...
  69. doi Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts
    Sangmin Kim
    Department of Dermatology, Seoul National University College of Medicine, Republic of Korea
    Cell Signal 20:1313-9. 2008
    ..by regulating two opposite signaling pathways: inhibiting TGF-beta1/smad signaling and activating a PI-3 kinase/Akt/mTOR-dependent pathway in human dermal fibroblasts, ultimately resulting in increased type I procollagen expression.
  70. doi A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin
    Aurélie Chabanon
    Institut National de la Sante et de la Recherche Medicale, Villejuif, France
    Stem Cells 26:3150-61. 2008
    ..We demonstrated a pivotal role of two downstream effectors of the PI3K/Akt pathway, FoxO3a and mammalian target of rapamycin, as connectors in the SDF-1-/TGF-beta-induced control of the cycling/quiescence switch and proposed a ..
  71. pmc Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
    Mansoor Ahmed
    National Center for Cell Science NCCS, NCCS Complex, Pune 411 007, India
    Mol Cancer 9:101. 2010
    ....
  72. pmc ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
    Audrey Carriere
    Department of Pathology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:567-77. 2011
    ..Increasing evidence suggests that the mammalian target of rapamycin (mTOR) plays an essential role in this process...
  73. pmc Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
    Jared M Dickinson
    Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Nutr 141:856-62. 2011
    The relationship between mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis during instances of amino acid surplus in humans is based solely on correlational data...
  74. pmc Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
    J E Kim
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, B107, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 97:14340-5. 2000
    ..FKBP12-rapamycin-associated protein (FRAP; also named mTOR or RAFT1), a member of the ataxia telangiectasia mutated (ATM)-related kinase family, governs a rapamycin-sensitive ..
  75. ncbi hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    Maya P Byfield
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:33076-82. 2005
    ..S6K1 is activated by growth factors such as insulin, and by mammalian target of rapamycin (mTOR), which is itself regulated by amino acids...
  76. pmc Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
    Zhi Hong Lu
    Division of Urologic Surgery, Department of Surgery, Siteman Cancer Center, and Program in Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3287-98. 2010
    ..Our findings offer direct evidence that RHEB facilitates multistage carcinogenesis through induction of multiple oncogenic mechanisms, perhaps contributing to the poor prognosis of patients with cancers overexpressing RHEB...
  77. pmc Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression
    I Mothe-Satney
    Departments of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 20:3558-67. 2000
    ..At an intermediate level, amino acids and insulin stimulate the phosphorylation of Thr36, Thr45, and Thr69 via mTOR-dependent processes that function independently of other sites in PHAS-I...
  78. ncbi Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    Marina K Holz
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26089-93. 2005
    Here we demonstrate that mammalian target of rapamycin (mTOR) is phosphorylated in a rapamycin-sensitive manner. We show that S6 kinase 1 (S6K1), but not Akt, directly phosphorylates mTOR in cell-free in vitro system and in cells...
  79. ncbi mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
    Li Hui
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    J Biol Chem 280:35829-35. 2005
    ..line MDA-MB-231 suppresses the activity of the putative tumor suppressor protein phosphatase 2A in a mammalian target of rapamycin (mTOR)-dependent manner...
  80. ncbi Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
    Anne Beugnet
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 278:40717-22. 2003
    ..1 (4E-BP1, also termed PHAS-I) is regulated by phosphorylation through the rapamycin-sensitive mTOR (mammalian target of rapamycin) pathway...
  81. pmc Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation
    V Kumar
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 19:1087-97. 2000
    ..The rapamycin and FK506-binding protein (FKBP)-target 1 (RAFT1, also known as FRAP) is a mammalian homolog of the Saccharomyces cerevisiae target of rapamycin proteins (mTOR) ..
  82. pmc A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    O N Ozes
    Department of Microbiology and Immunology, Indiana University School of Medicine and the Walther Oncology Center, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 98:4640-5. 2001
    ..Inhibition of IRS-1 tyrosine phosphorylation by TNF was blocked by rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), a downstream target of Akt...
  83. pmc Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    EMBO J 21:4070-80. 2002
    ..with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target of rapamycin (mTOR), mTOR-mediated phosphorylation of p53 on Ser15 (p53(S15)), p53-dependent upregulation of Bax ..
  84. ncbi Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
    Antonia Avila-Flores
    Department of Immunology and Oncology, National Centre for Biotechnology, Consejo Superior de Investigaciones Cientificas, Campus Cantoblanco, E 28049 Madrid, Spain
    J Biol Chem 280:10091-9. 2005
    The protein known as mammalian target of rapamycin (mTOR) regulates cell growth by integrating different stimuli, such as available nutrients and mitogenic factors...
  85. ncbi Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one
    Lisa M Ballou
    Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 282:24463-70. 2007
    Signaling through the mammalian target of rapamycin (mTOR) is hyperactivated in many human tumors, including hamartomas associated with tuberous sclerosis complex (TSC)...
  86. pmc TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells
    Ville Hietakangas
    Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, 117604, Singapore
    BMC Cancer 8:282. 2008
    ..Hydrophobic motif site phosphorylation is needed only for a subset of AKT functions. Whether proliferation of tumor cells depends on TORC2 activity has not been thoroughly explored...
  87. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
    We have shown that the mammalian target of rapamycin (mTOR) down-regulates thrombin-induced ICAM-1 expression in endothelial cells by suppressing the activation of NF-kappaB...
  88. pmc Relation between outcomes and localisation of p-mTOR expression in gastric cancer
    T Murayama
    Department of Surgical Oncology, Tokyo Medical and Dental University, Yushima, Bunkyo, Japan
    Br J Cancer 100:782-8. 2009
    The mammalian target of rapamycin (mTOR), a Ser/Thr protein kinase that mediates intracellular signalling related to cell growth, proliferation, and differentiation, has received considerable interest as a possible target for cancer ..
  89. ncbi Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
    S Isotani
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:34493-8. 1999
    ..in a manner that can be overcome by coexpression of p70alpha with a rapamycin-resistant mutant of the mammalian target of rapamycin (mTOR) but only if the mTOR kinase domain is intact...
  90. pmc Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2852-64. 2001
    ..Finally, we show that phosphorylation of Ser 65 and Thr 70 alone is insufficient to block binding to eIF4E, indicating that a combination of phosphorylation events is necessary to dissociate 4E-BP1 from eIF4E...
  91. ncbi Mammalian TOR: a homeostatic ATP sensor
    P B Dennis
    The Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Science 294:1102-5. 2001
    ..When nutrient concentrations change, particularly those of essential amino acids, the mammalian Target of Rapamycin (mTOR) functions in regulatory pathways that control ribosome biogenesis and cell growth...
  92. ncbi Identification of a conserved motif required for mTOR signaling
    Stefanie S Schalm
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 12:632-9. 2002
    The mammalian target of rapamycin (mTOR) controls the translation machinery via activation of S6 kinases 1 and 2 (S6K1/2) and inhibition of the eukaryotic initiation factor 4E (eIF4E) binding proteins 1, 2, and 3 (4E-BP1/2/3)...
  93. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..the ability of this integrin to activate the PI-3K-Akt pathway and, consequently, the rapamycin-sensitive kinase mTOR that can phosphorylate 4E-BP1...
  94. ncbi mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    Do Hyung Kim
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 110:163-75. 2002
    mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth...
  95. ncbi Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    b>mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha...
  96. ncbi The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    Ewan M Smith
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 280:18717-27. 2005
    Amino acids positively regulate signaling through the mammalian target of rapamycin (mTOR). Recent work demonstrated the importance of the tuberous sclerosis protein TSC2 for regulation of mTOR by insulin...
  97. ncbi mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    Richard C Hresko
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:40406-16. 2005
    ..mutated (ATM) gene product, integrin-linked kinase (ILK), protein kinase Calpha (PKCalpha), and mammalian target of rapamycin (mTOR), when complexed to rapamycin-insensitive companion of mTOR (RICTOR), have all been identified ..
  98. ncbi Localization of Rheb to the endomembrane is critical for its signaling function
    Claudia Buerger
    Division of Signaling Biology, Ontario Cancer Institute, University Health Network, 610 University Ave, Toronto, Ont, Canada M5G 2M9
    Biochem Biophys Res Commun 344:869-80. 2006
    Rheb, a small GTPase, has emerged as a key molecular switch that directly regulates the activity of the mammalian target of rapamycin (mTOR)...
  99. ncbi Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:3935-41. 2006
    ..This study was conducted to determine whether any of these markers are associated with survival time and response to radiation in glioblastoma...
  100. ncbi PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals
    Sang Hoon Ha
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbook 790 784, Republic of Korea
    Cell Signal 18:2283-91. 2006
    Mammalian target-of-rapamycin (mTOR), which is a master controller of cell growth, senses a mitogenic signal in part through the lipid second messenger phosphatidic acid (PA), generated by phospholipase D (PLD)...
  101. ncbi The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    Stefan M Schieke
    Cardiology Branch, Laboratory of Cardiac Energetics, Flow Cytometry Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:27643-52. 2006
    ..Here we demonstrate that in mammalian cells the mammalian TOR (mTOR) pathway plays a significant role in determining both resting oxygen consumption and oxidative capacity...

Research Grants118 found, 100 shown here

  1. The mTOR pathway in neuronal death and epileptogenesis
    Yunfei Huang; Fiscal Year: 2011
    ..We have recently established that NMDAR activation regulates the mammalian target of rapamycin (mTOR) pathway...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..A protein in the body called mTOR also plays a critical role in regulating how cells divide and grow and obtain their blood supply...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..A protein in the body called mTOR also plays a critical role in regulating how cells divide and grow and obtain their blood supply...
  4. Xinjun Zhu; Fiscal Year: 2014
    ..Rapamycin's action is mediated by inhibiting the mammalian Target of Rapamycin pathway (mTOR). Inhibition of mTOR by rapamycin stimulates autophagy activity...
  5. Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2011
    ..We have data showing that targeting the mTOR signaling pathway is a novel and effective treatment strategy for ALPS...
  6. Solving the elusive mechanism of rapamycin action in lymphocytes
    David A Fruman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): mTOR is a serine/threonine kinase that is expressed ubiquitously. The mTOR enzyme is present in two cellular complexes, TORC1 and TORC2...
  7. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    b>mTOR is a protein kinase that signals in pathways involved in the control of cell growth and proliferation...
  8. Targeting Wnt and mTOR to expand hematopoietic stem cells
    Peter S Klein; Fiscal Year: 2012
    ..that GSK-3 suppresses two, distinct pathways in hematopoietic stem/progenitor cells (HSPCs), the Wnt/ss-catenin and mTOR pathways...
  9. C Edward Rose; Fiscal Year: 2015
    ..CXCR4 is the major chemokine receptor expressed on human fibrocytes, and its expression is down-regulated by the mTOR inhibitor, sirolimus;and 5) in an animal model of pulmonary fibrosis, administration of sirolimus results in ..
  10. ALOKE VIRMANI FINN; Fiscal Year: 2014
    ..in clinical practice are designed to elute pharmacologic agents such as sirolimus that inhibit the mammalian target of rapamycin (mTOR), a member of the phosphatidylinositol kinase-related family of Ser/Thr kinase...
  11. Targeting Akt signaling in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2013
    ..We recently demonstrated that targeting mTOR signaling with the mTORC1 inhibitor sirolimus is effective in preclinical models and in children with ALPS...
  12. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..evidence that over-nutrition and angiotensin II (ANG II) may promote INS resistance through the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling pathway...
  13. JAMES RUSSELL SOWERS; Fiscal Year: 2016
    ..There is emerging evidence that enhanced activation of the RAAS may promote INS resistance through the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling pathway...
  14. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
    ..Our laboratory has had considerable success in developing first-in-class inhibitors of ALK, Mps1, Erk5, mTor, LRRK2, FGFRs, JNKs, and the T790M mutant form of EGFR and in using these compounds to validate new cancer targets...
  15. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..the ubiquitination and turnover of the kinase, and determine the roles and functional significance of the mTOR/S6 kinase and AMP kinase pathways in these regulatory processes (Aim 2)...
  16. Joseph Avruch; Fiscal Year: 2016
    ..In AIM1, we propose to elucidate in detail the mechanism by which Rheb-GTP activates mTOR complex 1...
  17. Role of Adipose Autophagy in Metabolism
    Do Hyung Kim; Fiscal Year: 2010
    ..A crucial step for autophagy induction involves inhibition of mammalian target of rapamycin (mTOR), a master controller of cell growth and a nutrient-regulated protein kinase...
  18. STUART KEITH CALDERWOOD; Fiscal Year: 2014
    ..transcription factor 1 (HSF1) and MLL1/trithorax) through binding to RNA and phosphorylation by the protein kinase mTOR. We aim to trace this novel pathway leading from the initial effects of hyperthermia on translation, transmitted to ..
  19. COURTNEY BLAKE NICHOLS; Fiscal Year: 2014
    ..These constructs will be transfected into isolated adult cardiomyocytes for live cell imaging and the use of FRAP and TIRF will be employed to investigate the dynamics of the signaling pathways...
  20. Efficacy Of Metformin In The Methylnitrosourea-Induced Model Of ER
    Terisa Davis; Fiscal Year: 2013
    ..stress, activation of ATP-activated protein kinase (AMPK), and inhibition of mammalian target ofrapamycin (mTOR)...
  21. REUBEN JAMES SHAW; Fiscal Year: 2016
    ..to the tumor suppressor activity of LKB1, including AMPK phosphorylation of core components in the mammalian target of rapamycin (mTOR) and autophagy pathways...
  22. JULIE BEATRICE CECILE BOSSUYT; Fiscal Year: 2014
    ..will be done in isolated, adult ventricular myocytes, using our innovative fluorescence methods (FRET, TIRF, FRAP measurements) complemented by molecular and biochemistry approaches...
  23. Estela Jacinto; Fiscal Year: 2016
    ..The mammalian target of rapamycin (mTOR) plays a central role in cell growth by promoting protein synthesis in response to nutrients, ..
  24. Yuan Xiang Tao; Fiscal Year: 2016
    ..b>Mammalian target of rapamycin (mTOR), a serine-threonine protein kinase, controls protein translation via phosphorylation of ..
  25. Kun Liang Guan; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The mammalian target of rapamycin (mTOR) is a central cell growth regulator that integrates a wide range of growth stimulating and inhibitory signals...
  26. Cindy Puente; Fiscal Year: 2015
    ..Ulk1 is a protein kinase mediating the function of the nutrient-sensing kinase mTOR. Atg13 is a regulatory protein of Ulk1...
  27. Estela Jacinto; Fiscal Year: 2016
    ..The mammalian target of rapamycin (mTOR) is a protein kinase that is inhibited by the potential anti-cancer drug, rapamycin, and plays a ..
  28. Soumitro Pal; Fiscal Year: 2014
    ..It has been observed that transplant patients receiving the mTOR inhibitor rapamycin (RAPA) do not develop cancer at the same rate as those receiving other immunosuppressive agents ..
  29. Jonathan D Powell; Fiscal Year: 2016
    ..We propose that the highly evolutionarily conserved threonine/serine protein kinase the mammalian Target of Rapamycin (mTOR) plays a critical role in integrating these cues and dictating the outcome of antigen ..
  30. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..We have identified AKT regulation of GATA-1 and FoxO3 transcription factors and mTOR kinase as critical for coordination of erythroid cell division and maturation...
  31. RICHARD JOSEPH PIETRAS; Fiscal Year: 2014
    ..to disrupt critical cross-talk between insulin/IGF-1 and GPCR signaling pathways and ERK;as well as Rag GTPases and mTOR. Laboratory studies show that metformin markedly inhibits growth of human pancreatic cancer cells xenografted in ..
  32. Role of Intestinal Cell Kinase in the Intestinal Epithelium
    Zheng Fu; Fiscal Year: 2013
    ..possibly by selectively regulating protein translation of key cell cycle regulators through the mammalian target of rapamycin (mTOR) pathway...
  33. Role of Ca2+/calmodulin kinases in skeletal muscle glucose transport and growth.
    CAROL WITCZAK; Fiscal Year: 2013
    ..shifts towards decreased protein synthesis, and this occurs via a decrease in the activation of the mammalian target of rapamycin (mTOR) signaling cascade...
  34. Jonathan M Backer; Fiscal Year: 2015
    ..of hVps34 complex formation, both at the whole cell level and, using fluorescence recovery after photobleaching (FRAP), on the autophagosomal membrane...
  35. Novel multivalent/multifunctional agents derived from a humanized anti-insulin-li
    Thomas M Cardillo; Fiscal Year: 2010
    ..and PTK targeted therapies with anti-vascular endothelial growth factor (VEGF) receptor antibodies or mammalian target of rapamycin (mTOR) inhibitors, such as temsirolimus...
  36. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
    ..Fluorescence recovery after photobleaching (FRAP) analysis of GFP-tagged focal adhesion components will be used to assess CaMKII4-dependent regulation of focal ..
  37. Michael W Schwartz; Fiscal Year: 2016
    ..Signaling molecules downstream of PI3K include protein kinase B (PKB) and mammalian target of rapamycin (mTOR), both of which are also implicated in hypothalamic control of food intake...
  38. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..depressed local IGF-1 production and increased myostatin production, (2.) impaired activation of PI3K/Akt/mTOR signaling, with attenuation of the downstream pathways that suppress degradation and activate protein synthesis, ..
  39. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2012
    ..b>Mammalian target of rapamycin (mTOR) is a protein kinase that integrates signals from growth factors (GFs) &nutrients to ..
  40. ROSALIND ANNE COLEMAN; Fiscal Year: 2016
    ..fatty acid composition of phospholipids and TAG, and to regulate nutrient-mediated signaling cascades that involve mTOR, PPAR?, and protein kinase C...
  41. Novel AMPK Activators in Breast Cancer Prevention
    Ching Shih Chen; Fiscal Year: 2012
    ..of energy homeostasis and insulin sensitivity, and cancer cell growth and survival through the regulation of mTOR signaling pathways, the suppression of inflammatory cytokines, especially interleukin (IL)-6, the stimulation of ..
  42. David M Sabatini; Fiscal Year: 2016
    ..mTORC1 is a protein kinase composed of the mTOR catalytic subunit and the associated proteins raptor, mLST8/G[unreadable]L, and PRAS40, and the central component ..
  43. Dhiren R Thakker; Fiscal Year: 2014
    ..endometrial hyperplasia and cancer through AMP-activated protein kinase (AMPK) activation and inhibition of the mTOR pathway. The only available treatment options for endometrial hyperplasia are progestin therapy or hysterectomy...
  44. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2012
    ..In the current application, we propose to characterize the specific downstream elements of mTOR (mammalian target of rapamycin), which orchestrates both these processes...
  45. Mammalian Target of Rapamycin (mTOR) signaling in health and longetivity
    DUDLEY WILLIAM LAMMING; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The mammalian target of rapamycin (mTOR) signaling pathway regulates growth and metabolism in response to the availability of nutrients...
  46. Delineating neuroprotective mechanisms mediated by the VEGFR2 signaling pathway
    PATRICIA B ROCKWELL; Fiscal Year: 2012
    ..neuroprotection through the activation of a Phosphatidylinositol 3'-kinase/Protein Kinase B/Akt/mammalian Target of Rapamycin (PI3-K/Akt/mTOR) and the mitogen-activated protein kinase kinase/extracellular signal-regulated ..
  47. Role of autophagy on the modulation of CYP2E1 alcohol liver toxicity
    Arthur I Cederbaum; Fiscal Year: 2013
    ..activated protein kinases, hepatoprotective defense, autophagy and autophagy regulators such as Bcl-2, AMPK, mTOR. For in- vivo studies, wild type SV129 mice, SV129 CYP2E1 knockout (KO) mice, and SV129 CYP2E1 knockin (KI) mice in ..
  48. Christopher D Morrison; Fiscal Year: 2014
    ..One involves the intracellular signaling molecules mTOR (mammalian target of rapamycin) and AMP-activated protein kinase (AMPK);the second involves the local brain metabolism of leucine...
  49. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..on the regulation and phosphorylation/activation of key signaling proteins including MYCN, p27Kip1, Cdk2, Akt, and mTOR. In Specific Aim 3 we will elucidate the role of ODC in cell signaling by examining its interaction with two new ..
  50. AMPK as a molecular target for chemoprevention by apigenin in preneoplastic skin
    Xin Tong; Fiscal Year: 2013
    ..The activation of AMPK results in inhibition of mTOR signaling, which relieves the block to the autophagy pathway, further inducing autophagy in human keratinocytes...
  51. Sean P Didion; Fiscal Year: 2014
    ..The mammalian target of rapamycin (mTOR;a member of the phosphoinositide 3-kinase-related kinase family of protein kinases) has recently ..
  52. Role of TTK/Mps-1 upregulation by Ral GTPase activation in pancreatic oncogenesis
    Jeran K Stratford; Fiscal Year: 2013
    ..The canonical K-Ras effector pathways, Raf-MEK-ERK and PI3K-AKT-mTOR have received the most attention with >40 inhibitors of these two pathways currently under evaluation in ..
  53. John Blenis; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Signaling by the mTOR protein kinase complex 1 (mTORC1) plays a major role in proper differentiation and development, and in regulating normal cellular homeostasis...
  54. Phase II Study of Rapamycin for Complicated Vascular Anomalies IND Exempt
    DENISE MARTIN ADAMS; Fiscal Year: 2012
    ..supporting the essential regulatory function of the phosphatidylinositol-3-kinase/Protein Kinase B /mammalian target of rapamycin (PI 3-kinase/Akt/mTOR) pathway in vascular growth and organization and suggest a therapeutic target ..
  55. William B Mair; Fiscal Year: 2016
    ..Although nutrient- sensing mediators of DR have been identified, such as mTOR, FOXO/As and the sirtuins, these central nodes recapitulate the entirety of the response, making them sub-optimal ..
  56. Regulation of the novel mTOR suppressor DDIT4 in the failing heart
    Yingjie Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): AMP-activated protein kinase (AMPK) negatively regulates mammalian target of rapamycin (mTOR), the master regulator of translational machinery and cell growth...
  57. Channing J Der; Fiscal Year: 2016
    ..the more studied Raf-MEK-ERK mitogen-activated protein kinase cascade or phosphatidylinositol 3-kinase (PI3K)-AKT-mTOR effector pathways, may be the most critical signaling mechanism for the K-Ras-mediated tumorigenic, invasive and ..
  58. Angelique Bordey; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This proposal will test the hypothesis that the direct mTOR effectors and downstream as well as mTOR-independent molecules contribute to cortical neuron hypertrophy and misplacement in Tuberous ..
  59. David M Sabatini; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The mTOR pathway is a signaling system that regulates growth and metabolism in response to the nutritional state of the organism...
  60. Chemoprevention of Peutz-Jeghers Polyposis in a Mouse Model by Niclosamide
    Chongjuan Wei; Fiscal Year: 2012
    ..LKB1 has been shown to negatively regulate the mammalian target of rapamycin (mTOR) via AMP-activated protein kinase activation of the TSC2 tumor suppressor...
  61. Brendan D Manning; Fiscal Year: 2015
    ..The pathways involving the lipid kinase PI3K and the protein kinase mTOR are intimately linked in a cellular network, referred to here as the PI3K-TSC-mTOR network, that is comprised of ..
  62. Zhi Yang Tsun; Fiscal Year: 2014
    ..These insights will shed light on the pathogenesis of BHD and may lead to the rational development of novel therapies for cancer. ..
  63. Richard G Moran; Fiscal Year: 2014
    ..have lost the function of tumor suppressor genes (LKB1, PTEN, TSC1/2) controlling energy metabolism on the Akt-mTOR pathway or have hyperactivity of oncogenes (PI3kinase, Akt) on this same pathway...
  64. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..i) Design and construct and improve electronic circuits to control the galvometric XY mirror on our multi-angle FRAP/TIRFM (Aim 1B) and/or new auto-sensing calibration devices (Aim 2) or ii) Develop models or software to visualize ..
  65. Regulation and Function of hVps34 in Insulin Signaling
    Jonathan M Backer; Fiscal Year: 2010
    ..Aim 3 explores potential mechanisms of hVps34 signaling to S6K, including interactions with mTOR, Cdc42, and CISK. Finally, Aim 4 examines the function of the hVps34-associated protein beclin- 1...
  66. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..suppresses autophagy by activating insulin and IGF-1 receptors, which act via PI3K-PDK1 and Akt1 and 2 to activate mTOR dependent and independent pathways that suppress autophagy...
  67. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2011
    ..be the Tuberous Sclerosis heterodimer complex (TSC1/2) and Rheb, a Ras-like GTPase, Rheb is a positive regulator of mTOR signaling to TOR complex 1, that acts in part directly on TORC1...
  68. Junichi Sadoshima; Fiscal Year: 2016
    ..2. GSK-3b regulates survival and death of cardiomyocytes during I/R. Activation of GSK-3b during ischemia inhibits mTOR through a TSC2-dependent mechanism, stimulates autophagy, and protects the heart from cell death...
  69. Richard C Wang; Fiscal Year: 2016
    ..tumorigenesis;our model challenges the current paradigm that the regulation of autophagy occurs primarily through mTOR. Addressing the question of how autophagy is regulated will be essential not only for interpreting the results of ..
  70. David Pearce; Fiscal Year: 2015
    ..Recent evidence has identified mammalian target of rapamycin (mTOR) as the kinase mediating a key "gateway" phosphorylation event required for SGK1 activation...
  71. Saghi Ghaffari; Fiscal Year: 2015
    ..We developed evidence that the serine/threonine kinase mTOR engages in crosstalk with FoxO3 to control erythroid maturation...
  72. MICHAEL H OVERHOLTZER; Fiscal Year: 2014
    ..We have found that the mTOR protein kinase, a regulator of mRNA translation and autophagy, is required for a program of phagosome fission that ..
  73. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..in response to energy stress and inhibits energy-consuming anabolic processes regulated by mammalian target of rapamycin (mTOR)...
  74. PATRICIA SALGADO; Fiscal Year: 2015
    ..patterns of synaptic activity that are most effective and define signal transduction pathways that activate mTOR-dependent protein synthesis...
  75. Ronald B Gartenhaus; Fiscal Year: 2015
    ..e., NF8B inhibitor, dual PI3K/AKT inhibitor, mTOR inhibitor), will effectively repress the lymphoma phenotype pre-clinically in B-cell and T-cell NHL cells, in vivo ..
  76. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..to rapamycin in the form of rejection or GVHD corresponds to biochemical resistance to rapamycin at the level of mTOR target phosphorylation and whether a novel mTOR kinase inhibitor can overcome such biochemical resistance in vitro...
  77. Carla J Shatz; Fiscal Year: 2016
    ..in expression and phosphorylation levels will be assessed in candidate pathways including MAP Kinase, AKT and mTOR signaling...
  78. David J Kwiatkowski; Fiscal Year: 2016
    ..In addition, a variety of cancer studies have shown that the mTOR signaling pathway is a consistent target in the majority of cancers...
  79. Jian Huang; Fiscal Year: 2015
    ..Recently, the PTEN-PI3K-mTOR pathway has been demonstrated to play an essential role in HSC maintenance...
  80. Tuberin &hamartin in rapamycin-sensitive &insensitive smooth muscle cell growth
    Usamah S Kayyali; Fiscal Year: 2013
    ..G protein, GTP-Rheb (Ras homolog enriched in brain), with downstream constitutive activation of mTOR (mammalian target of rapamycin), S6Kinase (S6K) and S6, leading to increased cellular growth...
  81. Xiaogang Li; Fiscal Year: 2016
    ..the following evidence supports the connection between TNF?? and Id2 signaling pathways: 1) TNF?? activates mTOR through IKK? and mTOR regulates the functional differentiation of mammary epithelial cells through regulating the ..
  82. Novel Therapeutics for Translation Control in Breast Cancer
    Bulent Ozpolat; Fiscal Year: 2013
    ..This leads to the down-regulation of eEF-2K, which in turn negatively modulates mTOR. We also hypothesize that neutrally charged nanoliposomes carrying 5-NT effectively curb the growth of primary and ..
  83. XIAOFENG STEVEN ZHENG; Fiscal Year: 2016
    ..PI3K-mammalian/mechanistic TOR (mTOR) pathway is frequently hyper-activated in human cancers, leading to uncontrolled cancer growth, which is a major ..
  84. Do Hyung Kim; Fiscal Year: 2016
    ....
  85. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2013
    ..Generation of CD8+CCR7+ Tregs is enhanced in the presence of the mTOR inhibitor Rapamycin...
  86. John H Zhang; Fiscal Year: 2016
    ..Once stimulated, PARs will activate mTOR, which has been reported to induce overproduction of ECM proteins, thus resulting in obstruction and impaired CSF ..
  87. Ki-Ras Signaling in Pancreatic Cancer: Role of a Novel Akt Regulator
    Sushovan Guha; Fiscal Year: 2013
    ..the mechanism by which Ki-Ras activates Akt;and 2) Investigate the role of BSTA in the resistance of PDAC to mTOR inhibitors in vitro and in vivo...
  88. Shi Yong Sun; Fiscal Year: 2015
    ..The mammalian target of rapamycin (mTOR), coupled with raptor and rictor to form mTOR complex 1 (mTORC1) and mTORC complex 2 (mTORC2), ..
  89. Arunabh Bhattacharya; Fiscal Year: 2014
    ..Since induction of protein degradation pathways is modulated by PI3K/Akt signaling and downstream mTOR and FoxO3 pathways, and activation of NF-[unreadable]B, these pathways will be measured in cells and in isolated ..
  90. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..Previous studies in humans report that defects in autophagy promote genome instability. Additionally, mTOR inhibition and the induction of autophagy have been linked to p53 and Ataxia-telangiectasia mutated (ATM) signaling ..
  91. Leonidas C Platanias; Fiscal Year: 2016
    ..Work from our laboratory has established that the mTOR pathway is deregulated in Ph+ leukemias and has raised the possibility that such deregulation contributes to the ..
  92. Investigation of synergism between mTOR and eEF2 kinase pathways
    Alexey G Ryazanov; Fiscal Year: 2013
    ..We will test this hypothesis by determining whether inactivation of eEF2K can synergize with rapamycin in producing an anti-aging effect. PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page ..
  93. KOY Y SAETEURN; Fiscal Year: 2015
    ..TGF-b also activates non-Smad pathways including the PI3K-Akt-mTOR and Erk- MAP kinase pathways, key signaling pathways that are induced by receptor tyrosine kinases and are often ..
  94. Darren P Wallace; Fiscal Year: 2016
    ..ILK), a kinase that regulates cell proliferation and survival through activation of Akt, GSK-32/2-catenin and mTOR signaling pathways...
  95. Shi Yong Sun; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The mammalian target of rapamycin (mTOR) is a serine-threonine kinase and plays a critical role in promoting cell growth and survival, primarily through interactions with other proteins such as ..
  96. Albert R La Spada; Fiscal Year: 2016
    ..In particular, the molecular basis of mTOR inhibition of autophagy is unknown, and the issue of cross-talk between the autophagy pathway and S6 kinase ..
  97. Gen Sheng Wu; Fiscal Year: 2014
    ..Consequently, it activates AMPK and in turn inhibits mTOR activity, thus negating the latter's active suppression of autophagy...
  98. Angela N Carter; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The phosphoinositide 3-kinase/mammalian target of rapamycin signaling cascade (hereafter referred to as the mTOR cascade) is a universal regulator of cell growth, survival and proliferation...
  99. Hiroyuki Inuzuka; Fiscal Year: 2015
    ..showed that Fbw7 negatively regulates the stability of Raptor and Rictor, the essential accessory proteins of the mTOR complexes (mTORC). The mTOR pathway plays a pivotal role in sensing nutrition and energy in cells...
  100. Transporters and Trafficking in Polarized Epithelial Cells
    Mark Donowitz; Fiscal Year: 2013
    ..Tse), and Advanced Imaging (Two-Photon Microscopy, Confocal Microscopy, FRET/FRAP) Core (Core C, Director, O. Kovbasnjuk). Project 1, Knockout Models of PDZ Proteins and NHE3 Regulation (PI, M...
  101. Ken Inoki; Fiscal Year: 2016
    ..glomerular hypertrophy, and mesangial expansion, can be prevented by treatment with rapamycin, a specific mTOR inhibitor...