MTNR1B

Summary

Gene Symbol: MTNR1B
Description: melatonin receptor 1B
Alias: FGQTL2, MEL-1B-R, MT2, melatonin receptor type 1B, mel1b receptor, melatonin receptor 1B variant b, melatonin receptor MEL1B
Species: human

Top Publications

  1. pmc Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    Leen M 't Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:287-92. 2010
  2. ncbi MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells
    Lin Yuan
    Department of Structural and Cellular Biology, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Mol Cell Endocrinol 192:147-56. 2002
  3. doi Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists
    Séverine Devavry
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    J Pineal Res 53:29-37. 2012
  4. doi New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population
    Min Jin Go
    Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, Republic of Korea
    J Hum Genet 58:362-5. 2013
  5. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
  6. pmc Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 92:8734-8. 1995
  7. ncbi Melatonin in humans
    A Brzezinski
    Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    N Engl J Med 336:186-95. 1997
  8. ncbi Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
    Mohammed A Ayoub
    Department of Cell Biology, Institut Cochin, INSERM U 567, CNRS UMR 8104, 22 rue Mechain, 75014 Paris, France
    J Biol Chem 277:21522-8. 2002
  9. ncbi Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7
    Petr Mazna
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Biochem Biophys Res Commun 332:726-34. 2005
  10. pmc The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
    Angelique Levoye
    Department of Cell Biology, Institut Cochin, Paris, France
    EMBO J 25:3012-23. 2006

Research Grants

  1. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
  2. FASEB SRC on Melatonin Receptors: Actions and Therapeutics
    David Blask; Fiscal Year: 2011
  3. Vincent M Cassone; Fiscal Year: 2016
  4. Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
    Frank A Scheer; Fiscal Year: 2011
  5. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
  6. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
  7. Melatonin Regulation of MT2 Melatonin Receptors
    MATTHEW GERDIN; Fiscal Year: 2003
  8. MELATONIN-LIGHT INTERACTION ON CIRCADIAN ACTIVITY
    Margarita Dubocovich; Fiscal Year: 2003
  9. MECHANISMS UNDERLYING MELATONIN RECEPTOR FUNCTION
    PAULA WITT ENDERBY; Fiscal Year: 1999
  10. FASEB SRC on Melatonin Biology: Actions and Therapeutics
    JAMES MICHAEL OLCESE; Fiscal Year: 2013

Detail Information

Publications226 found, 100 shown here

  1. pmc Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    Leen M 't Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:287-92. 2010
    ..In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps...
  2. ncbi MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells
    Lin Yuan
    Department of Structural and Cellular Biology, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Mol Cell Endocrinol 192:147-56. 2002
    ..This response was blocked by an MT1/MT2 melatonin receptor antagonist...
  3. doi Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists
    Séverine Devavry
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    J Pineal Res 53:29-37. 2012
    ....
  4. doi New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population
    Min Jin Go
    Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, Republic of Korea
    J Hum Genet 58:362-5. 2013
    ..We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia. ..
  5. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
  6. pmc Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 92:8734-8. 1995
    ..The Mel1b receptor cDNA encodes a protein of 362 amino acids that is 60% identical at the amino acid level to the human Mel1a ..
  7. ncbi Melatonin in humans
    A Brzezinski
    Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    N Engl J Med 336:186-95. 1997
  8. ncbi Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
    Mohammed A Ayoub
    Department of Cell Biology, Institut Cochin, INSERM U 567, CNRS UMR 8104, 22 rue Mechain, 75014 Paris, France
    J Biol Chem 277:21522-8. 2002
    ..Here, the closely related human MT1 and MT2 melatonin receptors (MT1R, MT2R) were used to address these issues...
  9. ncbi Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7
    Petr Mazna
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Biochem Biophys Res Commun 332:726-34. 2005
    ..between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 ..
  10. pmc The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
    Angelique Levoye
    Department of Cell Biology, Institut Cochin, Paris, France
    EMBO J 25:3012-23. 2006
    ..Pairing orphan GPCRs to potential heterodimerization partners might be of clinical importance and may become a general strategy to better understand the function of orphan GPCRs...
  11. ncbi Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis
    Xu Sheng Qiu
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, China
    Spine (Phila Pa 1976) 32:1748-53. 2007
    ..A genetic association study to comprehensively investigate variations of melatonin receptor 1B gene polymorphism by a set of tagging single nucleotide polymorphisms (tagSNPs) derived from the International Hapmap project...
  12. doi Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells
    Ina Stumpf
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 45:318-27. 2008
    ..The aim of this study was to examine the relevance of a second melatonin receptor (MT2) as well as the involvement of a third signaling cascade in mediating melatonin effects, i.e...
  13. pmc Variants in MTNR1B influence fasting glucose levels
    Inga Prokopenko
    1 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK 2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK 3 These authors contributed equally to this work
    Nat Genet 41:77-81. 2009
    ..Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies...
  14. pmc Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    Valeriya Lyssenko
    Department of Clinical Sciences in Malmoe, Unit of Diabetes and Endocrinology, Lund University Diabetes Centre, University Hospital, Malmoe, Sweden
    Nat Genet 41:82-8. 2009
    Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations...
  15. doi A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Nabila Bouatia-Naji
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Nat Genet 41:89-94. 2009
    In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7))...
  16. pmc Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3962. 2008
    Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia...
  17. doi A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals
    T Rönn
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University Diabetes Center, Malmo, Sweden
    Diabetologia 52:830-3. 2009
    Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in ..
  18. pmc Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
    Ema C Brito
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetes 58:1411-8. 2009
    ....
  19. pmc G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans
    Thomas Sparsø
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1450-6. 2009
    Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes...
  20. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  21. pmc Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk
    E Reiling
    Department of Molecular Cell Biology, Leiden University Medical Centre, PO Box 9600, 2300RC, Leiden, The Netherlands
    Diabetologia 52:1866-70. 2009
    ..protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG...
  22. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
    ..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
  23. pmc Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
    Clara Kelliny
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 58:2939-45. 2009
    ..The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children...
  24. pmc Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    Annemarie M Simonis-Bik
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:293-301. 2010
    ..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function...
  25. doi Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
    F Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Diabetologia 53:299-308. 2010
    ..To test fasting glucose association at four loci recently identified or verified by genome-wide association (GWA) studies of European populations, we performed a replication study in two Asian populations...
  26. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  27. pmc Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Diabetes 59:1266-75. 2010
    ..Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity)...
  28. pmc Mutation screening of melatonin-related genes in patients with autism spectrum disorders
    Lina Jonsson
    Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg University, Sweden
    BMC Med Genomics 3:10. 2010
    ....
  29. pmc MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai
    Chen Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Med Genet 11:59. 2010
    ..studies (GWAS) in White Europeans have shown that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated with fasting glucose and type 2 diabetes, which has also been replicated in several Asian ..
  30. doi Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
    M Y Kan
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    Diabet Med 27:598-602. 2010
    To investigate the two variants (rs1387153 and rs10830963) near/in the melatonin receptor 1B gene (MTNR1B) and to determine their association with Type 2 diabetes, as well as with the regulation of fasting plasma glucose (FPG) in Han ..
  31. pmc Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects
    Claudia Ha Ting Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e11428. 2010
    Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes ..
  32. pmc Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 5:e11761. 2010
    Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and MTNR1B were found to modulate the fasting glucose levels...
  33. doi No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study
    L Olsson
    Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Diabetologia 54:1375-8. 2011
    Genetic variation in the melatonin receptor 1B (MTNR1B) is associated with type 2 diabetes. Melatonin contributes to the regulation of sleep, and sleep problems are a documented risk factor for type 2 diabetes...
  34. pmc A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals
    Yan Ling
    Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Cardiovasc Diabetol 10:27. 2011
    Several studies have shown that common variants in the MTNR1B gene were associated with fasting glucose level and type 2 diabetes...
  35. pmc A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity
    L F Been
    Department of Pediatrics, Section of Genetics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Nutr Metab Cardiovasc Dis 22:944-51. 2012
    Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association studies (GWAS)...
  36. pmc Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus
    Jason Y Kim
    Department of Life Science, Sogang University, Department of Obstetrics and Gynecology, Cheil General Hospital and Women s Healthcare Center, 1 Shinsu dong, Mapo gu, Seoul, 121 742, Republic of Korea
    BMC Med Genet 12:82. 2011
    ..diabetes mellitus (GDM) share similar characteristics, we suspected that the two genetic polymorphisms in MTNR1B may be associated with GDM, and conducted association studies between the polymorphisms and the disease...
  37. pmc Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population
    Ying Wang
    Key laboratory of Endocrine, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    PLoS ONE 6:e26953. 2011
    ..To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women...
  38. pmc Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
    Amelie Bonnefond
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, Lille Pasteur Institute, France
    Nat Genet 44:297-301. 2012
    Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2)...
  39. ncbi The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
    Margarita Vlassi
    Endocrine Unit, 2nd Department of Obstetrics and Gynaecology, Aretaieion University Hospital, Athens Medical School, Greece
    Hormones (Athens) 11:70-6. 2012
    To investigate the association between Gestational Diabetes Mellitus (GDM) and the variants rs10830963 and rs1387153 in the MTNR1B locus in a sample of the Greek population.
  40. pmc Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women
    Shunyao Liao
    Diabetes Center, Sichuan Academy of Medical Science and Sichuan Provincial People s Hospital, Chengdu, China
    PLoS ONE 7:e40113. 2012
    This study aimed to explore the association of MTNR1B genetic variants with gestational plasma glucose homeostasis in pregnant Chinese women.
  41. pmc Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis
    Qing Xia
    Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P R China
    PLoS ONE 7:e50107. 2012
    Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G protein-coupled receptor superfamily involved in insulin secretion, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was ..
  42. doi Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women
    Chao Li
    Department of Obstetrics, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
    Gynecol Obstet Invest 76:221-7. 2013
    The purpose of this study was to investigate the association between MTNR1A and MTNR1B gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women.
  43. ncbi Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers
    Mohammed A Ayoub
    Department of Cell Biology, Institut Cochin, Paris, France
    Mol Pharmacol 66:312-21. 2004
    ....
  44. pmc Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
    C Langenberg
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 52:1537-42. 2009
    We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in healthy, diabetes-free individuals, is associated with measures of beta cell function and whole-body ..
  45. doi Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome
    Chao Li
    Shandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine, Provincial Hospital affiliated to Shandong University, Jinan 250021, China
    Mol Hum Reprod 17:193-8. 2011
    The aim of the present study was to determine whether or not the 'melatonin receptor (MTNR1B)' gene polymorphisms are associated with a predisposition for polycystic ovary syndrome (PCOS)...
  46. doi Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS
    Christina Holzapfel
    Else Kroener Fresenius Centre for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Universitat Munchen, Munich, Germany
    Eur J Endocrinol 164:205-12. 2011
    Genome-wide association studies have shown that the melatonin receptor 1B (MTNR1B) gene locus is strongly associated with fasting glucose and β-cell function...
  47. doi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
    ..a genetic association study was performed on 126 patients with adolescent idiopathic scoliosis and 197 healthy controls from independent Hungarian pedigrees...
  48. doi Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents
    Jie Yun Song
    Division of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China
    Obes Facts 4:197-203. 2011
    ..We aimed to identify whether the risk G-allele was associated with fasting glucose level and other pre-diabetic and obesity-related phenotypes in Chinese children and adolescents...
  49. pmc A genome-wide association study of gestational diabetes mellitus in Korean women
    Soo Heon Kwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes 61:531-41. 2012
    ..518; P=6.65×10(-16)). A variant near MTNR1B, rs10830962, was also significantly associated with the risk of GDM (1.454; P=2.49×10(-13))...
  50. pmc Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: in vitro and in vivo evidence
    Michael J Jarzynka
    Division of Pharmaceutical Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, USA
    J Pineal Res 46:161-71. 2009
    ..We extended our findings to MT2 melatonin receptors using both in vitro and in vivo approaches...
  51. ncbi Asymmetric expression of melatonin receptor mRNA in bilateral paravertebral muscles in adolescent idiopathic scoliosis
    Yong Qiu
    Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Spine (Phila Pa 1976) 32:667-72. 2007
    ..OBJECTIVES.: To investigate the change of melatonin receptor mRNA expression in bilateral paravertebral muscles in AIS, congenital scoliosis (CS), and control in order to analyze its association to the pathogenesis of AIS...
  52. doi Photoperiodic regulation of MT1 and MT2 melatonin receptor expression in spleen and thymus of a tropical rodent Funambulus pennanti during reproductively active and inactive phases
    Raise Ahmad
    Pineal Research Lab, Department of Zoology, Banaras Hindu University, Varanasi, India
    Chronobiol Int 27:446-62. 2010
    ..In the present study, we accessed the high affinity membrane melatonin receptors MT1 and MT2 expression dynamics in lymphoid organs (i.e...
  53. ncbi Melatonin receptors in rat hippocampus: molecular and functional investigations
    Ulrich Musshoff
    Institute of Physiology, University of Munster, Germany
    Hippocampus 12:165-73. 2002
    ..The RT-PCR data revealed that transcripts for both the MT1 and MT2 melatonin receptors are present in the dentate gyrus, CA3, and CA1 regions, and the subiculum of the hippocampus...
  54. ncbi Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms
    M L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Institute for Neuroscience, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    FASEB J 12:1211-20. 1998
    This study demonstrates the involvement of the MT2 (Mel1b) melatonin receptor in mediating phase advances of circadian activity rhythms by melatonin...
  55. pmc Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction
    M J Lew
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 126:1408-18. 1999
    ..melatonin receptor agonists had the potency order 2-iodomelatonin > melatonin > S20098 > GR196429, and the MT2-selective antagonist luzindole antagonized the effects of melatonin with a low pK(B) of 6.1+/-0.1. 5...
  56. pmc A fragmented metazoan organellar genome: the two mitochondrial chromosomes of Hydra magnipapillata
    Oliver Voigt
    Courant Research Center Geobiology, Georg August Universitat Gottingen, Goldschmidtstr, 3, 37077 Gottingen, Germany
    BMC Genomics 9:350. 2008
    ..Here, we present the whole mt genome sequence from the hydrozoan Hydra magnipapillata, comprising the first sequence of a fragmented metazoan mt genome encoded on two linear mt chromosomes (mt1 and mt2).
  57. ncbi Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
    Matthew J Gerdin
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    FASEB J 18:1646-56. 2004
    ..biological clock, the suprachiasmatic nucleus (SCN) of the hypothalamus, through activation of G protein-coupled MT2 melatonin receptors...
  58. doi Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin
    Gene Chi Wai Man
    Faculty of Medicine, Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China
    J Pineal Res 49:69-77. 2010
    ..Recently, our group found that melatonin receptor 1B (MT2) gene polymorphism was associated with the occurrence of AIS...
  59. doi Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, Room BB813, NY 10032, USA
    Prog Neurobiol 85:335-53. 2008
    ..antioxidant activity, melatonin exerts many of its physiological actions by interacting with membrane MT1 and MT2 receptors and intracellular proteins such as quinone reductase 2, calmodulin, calreticulin and tubulin...
  60. doi Melatonin receptors in the brain of the European sea bass: An in situ hybridization and autoradiographic study
    Patricia Herrera-Pérez
    Department of Biology, Faculty of Marine and Environmental Sciences, University of Cadiz, Campus Rio San Pedro, E 11510 Puerto Real, Spain
    J Comp Neurol 518:3495-511. 2010
    ..Recently, we have cloned three different melatonin receptors in sea bass belonging to the MT1, MT2, and Mel1c subtypes...
  61. doi Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in endometrial cancer cell line
    Mari Watanabe
    Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Kanagawa, Japan
    J Obstet Gynaecol Res 34:567-73. 2008
    ..To determine the receptor subtypes of melatonin in estrogen receptor-positive endometrial cancer cell line, Ishikawa, and the influence of melatonin on chemosensitivity...
  62. doi Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon
    Keiji Nishiyama
    Pharmacology Research Laboratory, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 17 85, Jusohonmachi 2 chome, Yodogawa ku, Osaka 532 8686, Japan
    J Pharmacol Exp Ther 330:855-63. 2009
    ..In conclusion, this information will help us to understand the pharmacological effects of melatonin receptor agonists in monkeys...
  63. ncbi Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse
    M L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pineal Res 39:113-20. 2005
    In the mouse suprachiasmatic nucleus (SCN), melatonin activates MT1 and MT2 G-protein coupled receptors, which are involved primarily in inhibition of neuronal firing and phase shift of circadian rhythms...
  64. doi In vitro and in vivo antitumor activity of melatonin receptor agonists
    Lulu Mao
    Department of Structural and Cellular Biology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Pineal Res 49:210-21. 2010
    ..analogs with greater therapeutic effects, we have examined the in vitro and in vivo antimitotic activity of two MT1/MT2 melatonin receptor agonists, S23219-1 and S23478-1...
  65. ncbi Specific roles of methylcobamide:coenzyme M methyltransferase isozymes in metabolism of methanol and methylamines in Methanosarcina barkeri
    D J Ferguson
    Department of Microbiology, The Ohio State University, Columbus, 43210, USA
    J Biol Chem 271:5189-94. 1996
    ..was employed as a direct test for functional activities of isozymes of methylcobamide:coenzyme M methyltransferase (MT2-M and MT2-A) in the metabolic pathways of methane formation from: methanol, acetate, monomethylamine, dimethylamine,..
  66. ncbi Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor
    S Y Shiu
    Department of Physiology, The University of Hong Kong, China
    J Pineal Res 27:183-92. 1999
    ..Interestingly, the selective MT2 melatonin receptor ligand, 4-phenyl-2-propionamidotetraline (4-P-PDOT), was found to exert not only concentration-..
  67. ncbi Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis
    Carol A Hitchon
    Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Rheumatol 29:107-17. 2002
    ..We examined the expression and activity of the gelatinases and their regulators in psoriatic skin and synovium using tissue immunohistochemistry and a sensitive tissue based zymographic technique...
  68. doi Function and expression of melatonin receptors on human pancreatic islets
    Reshma D Ramracheya
    Beta Cell Development and Function Group, School of Biomedical and Health Sciences, King s College London, London, UK
    J Pineal Res 44:273-9. 2008
    ..is known to inhibit insulin secretion from rodent beta-cells through interactions with cell-surface MT1 and/or MT2 receptors, but the function of this hormone in human islets of Langerhans is not known...
  69. ncbi Ramelteon 8 mg/d versus placebo in patients with chronic insomnia: post hoc analysis of a 5-week trial using 50% or greater reduction in latency to persistent sleep as a measure of treatment effect
    Louis Mini
    Takeda Pharmaceuticals North America, Inc, Deerfield, Illinois 60015, USA
    Clin Ther 30:1316-23. 2008
    Ramelteon is a selective MT1/MT2 melatonin receptor agonist approved by the US Food and Drug Administration for insomnia treatment.
  70. doi Melatonin receptors in a pleuronectiform species, Solea senegalensis: Cloning, tissue expression, day-night and seasonal variations
    Francesca Confente
    Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, E 11510 Puerto Real, Spain
    Gen Comp Endocrinol 167:202-14. 2010
    ..In this study we have cloned three melatonin receptor subtypes (MT1, MT2 and Mel1c) in the Senegalese sole and analyzed their central and peripheral tissue distribution...
  71. ncbi Functional MT1 and MT2 melatonin receptors in mammals
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine Center for Drug Discovery and Chemical Biology, Chicago, IL 60611, USA
    Endocrine 27:101-10. 2005
    ..This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 G protein-coupled receptors viewed as potential targets for drug discovery...
  72. ncbi Expression of melatoninergic receptors in human placental choriocarcinoma cell lines
    Dave Lanoix
    Department of Chemistry and Biochemistry, Universite de Moncton, Moncton, New Brunswick, Canada
    Hum Reprod 21:1981-9. 2006
    ..To date, the expression and role of melatonin receptors in human placenta choriocarcinoma cell lines and in human term placental tissues remain to be elucidated...
  73. doi Genetic components of heat stress in finishing pigs: Parameter estimation
    B Zumbach
    Department of Animal and Dairy Science, University of Georgia, Athens 30602 2771, USA
    J Anim Sci 86:2076-81. 2008
    ..Variance components were estimated with 3 models: univariate (UNI)-not accounting for heat stress, 2-trait (MT2), and random regression (RR)...
  74. doi Melatonin transmits photoperiodic signals through the MT1 melatonin receptor
    Shinobu Yasuo
    Dr Senckenbergische Anatomie, Institute of Anatomie II, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    J Neurosci 29:2885-9. 2009
    Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of ..
  75. doi Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Neuroendocrinology 90:251-9. 2009
    ..A 2-iodomelatonin binding assay and RT-PCR analysis demonstrated that the cells expressed neither MT1 nor MT2. However, treatment of GT1-7 cells with the GnRH antagonist cetrorelix significantly increased 2-iodomelatonin ..
  76. ncbi The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors
    I C Sumaya
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pineal Res 39:170-7. 2005
    ..antidepressant-like effect in C3H/HeN mice during the forced swimming test (FST) following treatment with the MT1/MT2 melatonin receptor ligand, luzindole...
  77. ncbi In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
    G Scarlatti
    Unit of Immunobiology of HIV, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 3:1259-65. 1997
    ..CCR5, a specific RANTES, MIP-1alpha and MIP-1 receptor, is used preferentially by non-MT2-tropic HIV-1 and HIV-2 strains and by simian immunodeficiency virus (SIV), whereas CXCR4, a receptor for the C-X-C ..
  78. ncbi The melatonin receptor subtype MT2 is present in the human cardiovascular system
    Cem Ekmekcioglu
    Department of Physiology, Faculty of Medicine, University of Vienna, Vienna
    J Pineal Res 35:40-4. 2003
    ..As studies in experimental animals suggest that the MT2 melatonin receptor subtype is also present in the vasculature, we investigated whether the MT2 is expressed in ..
  79. doi Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells
    M Imbesi
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Neuroscience 155:1160-4. 2008
    The melatonin receptors MT1 and MT2 take part in the regulation of the activity (i.e. phosphorylation) of extracellular-signal-regulated kinase (ERK1/2), an enzyme involved in neuroplasticity...
  80. ncbi Melatonin receptor subtype MT2 (Mel 1b) and not mt1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity
    D L Drazen
    Department of Psychology, The Johns Hopkins University, Baltimore, MD, USA
    Neuroendocrinology 74:178-84. 2001
    ..The present study examined the contribution of specific melatonin receptor subtypes, mt1 (Mel 1a) and MT2 (Mel 1b), in mediating melatonin-induced enhancement of cell-mediated and humoral immune function in mice...
  81. ncbi MT1 melatonin receptor mRNA expression exhibits a circadian variation in the rat suprachiasmatic nuclei
    Vincent Joseph Poirel
    Laboratoire de Neurobiologie des Rythmes, CNRS UMR 7518, Universite Louis Pasteur, 12 rue de l Université, 67000 Strasbourg, France
    Brain Res 946:64-71. 2002
    The aim of the present study was to investigate the daily regulation of both MT1 and MT2 melatonin receptor subtype mRNA expression in the rat SCN in order to clarify their role in the daily variation of SCN melatonin receptors...
  82. ncbi Molecular pharmacology, regulation and function of mammalian melatonin receptors
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Front Biosci 8:d1093-108. 2003
    ..We also review melatonin-mediated responses through activation of melatonin receptors (MT1, MT2, and MT3) highlighting their involvement in modulation of CNS, hypothalamic-hypophyseal-gonadal axis, ..
  83. pmc Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers
    Lennard P Niles
    Department of Psychiatry and Behavioural Neurosciences, McMaster University 1200 Main Street West, Hamilton ON L8N 3Z5, Canada
    BMC Neurosci 5:41. 2004
    ..In view of recent evidence suggesting a role for the pineal hormone melatonin in vertebrate development, it was also of interest to determine whether its G protein-coupled MT1 and MT2 receptors are expressed in NSCs.
  84. ncbi Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    J Pineal Res 38:10-6. 2005
    The aim of the present study was to identify the distribution of the second melatonin receptor (MT2) in the human hippocampus of elderly controls and Alzheimer's disease (AD) patients...
  85. pmc The pattern of melatonin receptor expression in the brain may influence antidepressant treatment
    Eric Hirsch-Rodriguez
    Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 69:120-4. 2007
    The pineal hormone melatonin produces most of its biological effects via G protein-coupled receptors MT1 and MT2. In mammals, these receptors are expressed in various tissues and organs including in the brain...
  86. doi Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912 Chicago, IL 60612, USA
    Neurosci Lett 439:34-6. 2008
    ..of melatonin receptor stimulation on neuronal BDNF, we used a clinically available novel agonist for MT1 and MT2 melatonin receptors, ramelteon...
  87. doi Cloning and retinal expression of melatonin receptors in the European sea bass, Dicentrarchus labrax
    Sandrine Sauzet
    Universite Pierre et Marie Curie PARIS6, UMR7628, Laboratoire Arago, Avenue Fontaulé, BP44, F 66651 Banyuls sur Mer, Cedex, France
    Gen Comp Endocrinol 157:186-95. 2008
    ..different melatonin receptor subtypes in the sea bass Dicentrarchus labrax, belonging, respectively, to the MT1, MT2 and Mel1c subtypes...
  88. doi Gene structures, biochemical characterization and distribution of rat melatonin receptors
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, 113 8602, Japan
    J Physiol Sci 59:37-47. 2009
    ..cDNAs of two rat membrane melatonin receptor subtypes, melatonin receptor 1a (MT1) and melatonin receptor 1b (MT2), using a rapid amplification of cDNA end (RACE) method...
  89. doi Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia
    I Ching Lai
    Department of Psychiatry, Tzu Chi General Hospital, Hualien, Taiwan
    World J Biol Psychiatry 12:143-8. 2011
    ..Melatonin has a modulating effect on dopaminergic neurotransmission in the brain; therefore, the hypothesis of an association between the melatonin receptor genes (MTNR1A, MTNR1B) and antipsychotics-induced TD was examined in this study.
  90. doi Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    J Pineal Res 50:272-80. 2011
    ..Cultured AECs express melatonin receptor type 1A (MT1), but not melatonin receptor type 1B (MT2)...
  91. ncbi [Comparison of melatonin receptor mRNA expression in bilateral paravertebral muscles in adolescent idiopathic scoliosis]
    Yong Qiu
    Spine Service, Gulou Hospital, Medical School of Nanjing University, Nanjing 210008, China
    Zhonghua Wai Ke Za Zhi 44:826-9. 2006
    ..To study the change of melatonin receptor mRNA expression in paravertebral muscles in adolescent idiopathic scoliosis (AIS), and analyze its relationship with the etiology of AIS...
  92. ncbi Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice
    Pjotr Sheynzon
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Fachbereich Medizin der J W Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurosci Lett 407:48-52. 2006
    ..cells of wild-type mice (MelAABB) and of mice bearing targeted deletions of the Mel1a receptor (MelaaBB), the Mel1b receptor (MelAAbb) or of both receptor types (Melaabb) at five different time points of a light/dark cycle...
  93. pmc Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
    R Jockers
    Department of Cell Biology, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Br J Pharmacol 154:1182-95. 2008
    ..In mammals, two melatonin receptors, MT1 and MT2, have been cloned. They belong to the G-protein-coupled receptor (GPCR) superfamily...
  94. doi Lack of association between the promoter polymorphism of the MTNR1A gene and adolescent idiopathic scoliosis
    Xu Sheng Qiu
    Spine Surgery, The Affiliated Drum Town Hospital of Nanjing University Medical School, Nanjing, China
    Spine (Phila Pa 1976) 33:2204-7. 2008
    ..A genetic association study to investigate variation of the melatonin receptor 1A (MTNR1A) gene in adolescent idiopathic scoliosis (AIS) patients...
  95. pmc Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    PLoS ONE 5:e11495. 2010
    ..Here, we sequenced the melatonin receptor MTNR1A and MTNR1B, genes coding for MT1 and MT2 receptors, respectively, in a large panel of 941 individuals including 295 patients ..
  96. ncbi Labeled [³H]--thymidine incorporation in the DNA of 3T3-L1 preadipocytes due to MT₂- and not MT₃- melatonin receptor
    M Adamczyk-Sowa
    Department of Neurology in Zabrze, Medical University of Silesia, Poland
    J Physiol Pharmacol 65:135-43. 2014
    ..Summarizing, it has been proven that melatonin exerts a proproliferative effect on 3T3-L1 preadipocytes at physiological and supraphysiological concentrations, partially by MT₂, and not by MT₃ receptors...
  97. ncbi Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
    H Ueno
    Department of Molecular Immunology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 57:2055-60. 1997
    ..Three different membrane-type MMPs (MT-MMPs), MT1-, MT2-, and MT3-MMPs are thought to be activators of proMMP-2 in the tissues...
  98. ncbi Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragments
    A Bini
    Laboratory of Blood Coagulation Biochemistry, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Biochemistry 38:13928-36. 1999
    ..That does not occur with other MMPs such as MMP-1, -2, and -9 and MT2-MMP...
  99. ncbi Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists
    George N Karageorge
    Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492 7660, USA
    Bioorg Med Chem Lett 14:5881-4. 2004
    ..A series of tetrahydroisoquinolines has yielded potent MT(2) receptor antagonists, which are selective versus the MT(1) receptor...
  100. doi Muscarinic inhibition of hippocampal and striatal adenylyl cyclase is mainly due to the M(4) receptor
    Gonzalo Sanchez
    Instituto de Biología Celular and Neurociencia Prof Eduardo De Robertis, Facultad de Medicina, Universidad de Buenos Aires CONICET, Paraguay 2155, 2do piso, 1121 Buenos Aires, Argentina
    Neurochem Res 34:1363-71. 2009
    ..Highly selective muscarinic toxins MT1 and MT2-affinity order M(1) > or = M(4) >> others-and MT3-highly selective M(4) antagonist-did not show ..
  101. pmc Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...

Research Grants51

  1. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
    ..regulates circadian rhythmicity by activating two membrane-bound G-protein coupled receptors in humans: the MT1 and MT2. Melatonin receptor agonists represent a new class of drugs indicated for the treatment of insomnia and circadian ..
  2. FASEB SRC on Melatonin Receptors: Actions and Therapeutics
    David Blask; Fiscal Year: 2011
    ..Furthermore, melatonin ligands acting on MT1 and MT2 receptors have been marketed for the treatment of insomnia, circadian disorders and depression (Rozerem, Takeda ..
  3. Vincent M Cassone; Fiscal Year: 2016
    ..with strains of mice capable of producing melatonin cycles (C3H) and whether these processes are dependent the known melatonin receptor molecules by comparing wild-type with MT1 receptor, MT2 Receptor and MT2/MT2 receptor knockout mice.
  4. Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
    Frank A Scheer; Fiscal Year: 2011
    ..Interestingly, two newly discovered T2D risk variants are located in the melatonin receptor gene MTNR1B and in the core circadian clock gene CRY2, providing compelling and converging support that circadian and sleep ..
  5. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..rhythmicity by comparing melatonin proficient mice (C3H/f+/+) and melatonin receptor knock-out mice (MT1-/-, MT2-/- and MT1-/-MT2-/-) in C3H/f+/+...
  6. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    ..The goal of this study is to determine the distribution of melatonin receptors [MT1 (formerly Mel1a), MT2 (formerly Mel1b)] in the circadian and limbic system of a diurnal non-human primate...
  7. Melatonin Regulation of MT2 Melatonin Receptors
    MATTHEW GERDIN; Fiscal Year: 2003
    This proposal aims to investigate the mechanisms by which melatonin (MET) regulates MT2 melatonin receptors and assess the physiological significance of these events...
  8. MELATONIN-LIGHT INTERACTION ON CIRCADIAN ACTIVITY
    Margarita Dubocovich; Fiscal Year: 2003
    ..and functional mechanism(s) through which activation of G-protein linked melatonin receptor subtypes (mt1 and MT2) and putative nuclear melatonin receptors (ROR-beta) within the circadian timing system (retina, SCN and IGL) ..
  9. MECHANISMS UNDERLYING MELATONIN RECEPTOR FUNCTION
    PAULA WITT ENDERBY; Fiscal Year: 1999
    ..proposal will focus on the molecular basis of desensitization of GPRs of two related melatonin receptors, mt1 and mt2. The mt1 melatonin receptors attenuate adenylyl cyclase and are primarily expressed in the brain...
  10. FASEB SRC on Melatonin Biology: Actions and Therapeutics
    JAMES MICHAEL OLCESE; Fiscal Year: 2013
    ..Furthermore, the first melatonin ligand acting on MT1 and MT2 receptors has been marketed for the treatment of insomnia and circadian sleep disorders (Ramelteon, by Takeda ..
  11. Melatonin Analog PD6735 and Anxiety
    Frank Zemlan; Fiscal Year: 2006
    ..Additional pre-clinical studies indicate that PD6735 is safe and is a high-affinity melatonin agonist at MT1 and MT2 receptors...
  12. Efficacy of the Melatonin Agonist in the Treatment of Depression
    Frank Zemlan; Fiscal Year: 2007
    ..Additional preclinical studies indicate that PD6735 is safe and is a high-affinity agonist at MT1 and MT2 receptors...
  13. A mechanism of metal-mediated immunosuppression
    MICHAEL LYNES; Fiscal Year: 2007
    ..has multiple Mt1 genes that drive MT overexpression, and the second carries targeted disruptions of the Mt1 and Mt2 genes...
  14. STEPHEN JOSEPH WEISS; Fiscal Year: 2015
    ..To this end, we have generated a unique cohort of endothelial cell-specific Snail1-, MT1-MMP- and MT2-MMP-knockout mice as well as MT1-MMP BAC transgenic rescue mice that allow for the testing of a new series of ..
  15. RAFAEL A FRIDMAN; Fiscal Year: 2015
    ..We now show a novel interaction between three members of the MT-MMP family, MT1- (MMP14), MT2- (MMP15), and MT3- (MP16) MP (refered here to as MT-MMPs), and the discoidin domain receptors (DDRs), a unique set ..
  16. STEPHEN JOSEPH WEISS; Fiscal Year: 2016
    ..More recent data now indicate that MT1-MMP activity may be complemented by a second, membrane-anchored MMP, termed MT2-MMP...
  17. NOVEL LINKAGES OF THE PEPTIDOGLYCAN LAYER: ADAPTATION &RESISTANCE TO B-LACTAMS
    Gyanu Lamichhane; Fiscal Year: 2011
    ..We have determined the molecular structure of Ldt{Mt2} by solving its crystal structure...
  18. DNA Methylation in Drosophila
    Keith A Maggert; Fiscal Year: 2010
    ..this hypothesis on analysis of genomic imprints in fruit flies mutant for the sole known DNA methyltransferase, Mt2. Our preliminary data suggest that DNA methylation is required maternally for establishment of paternal imprints, ..
  19. PROGRESSION OF CHEMICAL INDUCED SKIN TUMORS
    Andres Klein Szanto; Fiscal Year: 2007
    ..mice with other transgenic animals expressing PACE4 substrates targeted to the skin such as IGF-1, TGF-13 and MT2-MMP This approach will establish the in vivo hierarchy of the respective substrate activation in the acceleration ..
  20. Biology of a New DAP12 Associated Receptor Family
    William Seaman; Fiscal Year: 2005
    ..When expressed in MT2 macrophages, MDI-1 associates with endogenous DAP12 and stimulates the production of nitric oxide...
  21. Chicago State-Northwestern MS-PhD Bridge to the Future
    M Rundell; Fiscal Year: 2008
    ..The BP will continue to benefit from periodic examination and assessment by experienced and highly accomplished external advisors and evaluators. [unreadable] [unreadable] [unreadable]..
  22. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  23. Promoting Islet Transplantation with Synthetic Scaffolds
    WILLIAM LOWE; Fiscal Year: 2004
    ..abstract_text> ..
  24. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  25. PDX-1 Expression and Embryonic Stem Cells
    WILLIAM LOWE; Fiscal Year: 2004
    ..Thus, the proposed studies will address novel ways of promoting the differentiation of ES cells into islets with the ultimate goal of enhancing islet cell transplantation. ..
  26. Replication of GWAS for Maternal Glycemia, Birthweight and their Interaction
    WILLIAM LOWE; Fiscal Year: 2009
    ....
  27. Diabetes Genes: Maternal Glycemia and Birth Weight
    WILLIAM LOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. HYPERGLYCEMIA AND VASCULAR CELL SIGNALING
    WILLIAM LOWE; Fiscal Year: 2001
    ..Identifying the signaling pathways that mediate the effects of hyperglycemia on vascular cell function is critical to devising means to prevent these changes and their complications, such as atherosclerosis. ..
  29. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2008
    ..abstract_text> ..
  30. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    CHARLES FRANCE; Fiscal Year: 2003
    ....
  31. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2003
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  32. Fanyin Meng; Fiscal Year: 2016
    ..It is our firm belief that the results of these studies will provide information that will not only allow us to better understand cholangiocyte pathobiology but will also lead to treatments for cholestatic liver diseases. ..
  33. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..The in vitro model, if validated, has the potential to provide clinically important information on interactions involving HIV treatments and abusable drugs, at relatively low cost and with no human drug exposure. ..
  34. Phenotypes of HIV-1 Integrases
    William Robinson; Fiscal Year: 2009
    ..Inhibitors of integrase are in clinical testing. Understanding how HIV becomes resistant to these compounds and how such compounds interact with integrase are fundamental to the synthesis of better anti-HIV drugs. ..
  35. Pharmacogenetics of the acute response to sulfonylurea and metformin treatment in
    Jose Florez; Fiscal Year: 2008
    ..In addition, this pilot study will lay the groundwork for a long-term, outcomes-based pharmacogenetic clinical trial. [unreadable] [unreadable]..
  36. Genetic Mapping of Familial Idiopathic Scoliosis
    Jose Morcuende; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. Genetic variation in drug targets for type 2 diabetes
    Jose Florez; Fiscal Year: 2008
    ..This proposal should serve as the foundation for a large pharmacogenomics trial designed to evaluate the feasibility of genetically-tailored therapy in T2DM. ..
  38. GHB abuse: chemistry and neurobiology
    CHARLES FRANCE; Fiscal Year: 2003
    ..abstract_text> ..
  39. Intrnational Clubfoot Symposium
    Jose Morcuende; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  41. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2006
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  42. PLASTICITY OF MAMMALIAN CIRCADIAN AXIS
    Gianluca Tosini; Fiscal Year: 2003
    ..abstract_text> ..
  43. MDR1 and Related Proteins during HIV PI Exposure
    David Greenblatt; Fiscal Year: 2005
    ..The findings will be of importance in understanding lipid disorders related to PIs as well as the kinetics of drugs used to treat HIV and related disorders. ..
  44. Interactions Between Olive Leaf Extract and HIV Drugs
    Sylvia Lee Huang; Fiscal Year: 2005
    ..We hope that this information will provide an important knowledge base for anti-HIV therapy of OLE alone or in combination with HAART, as well as contribute to our understanding of viral pathogenesis. ..
  45. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2005
    ....
  46. Defining an HIV Integrase Inhibitor Binding Pocket
    William Robinson; Fiscal Year: 2004
    ..Moreover, by understanding the nature of inhibitor resistance, new molecules with activity against inhibitor-resistant HIV can be designed and synthesized. ..
  47. GARLIC PREPARATIONS AND ANTIRETROVIRAL DRUGS
    David Greenblatt; Fiscal Year: 2004
    ..The work will provide immediately applicable clinical data on garlic interactions with antiretrovirals, as well as mechanistic data identifying the interaction process and its predictability from in vitro models. ..
  48. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
  49. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2003
    ....