MSR1

Summary

Gene Symbol: MSR1
Description: macrophage scavenger receptor 1
Alias: CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2, macrophage scavenger receptor types I and II, macrophage acetylated LDL receptor I and II, macrophage scavenger receptor type III, scavenger receptor class A member 1
Species: human

Top Publications

  1. ncbi A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Lipid Res 39:531-43. 1998
  2. doi The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
    Celine Beauvillain
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Cancérologie Nantes Angers, Bâtiment Montéclair, 4 rue Larrey, Angers 49933, France
    J Hepatol 52:644-51. 2010
  3. doi Interleukin-10 down-regulates oxLDL induced expression of scavenger receptor A and Bak-1 in macrophages derived from THP-1 cells
    Hong Yang
    Tongji University School of Medicine, Shanghai 200092, China
    Arch Biochem Biophys 512:30-7. 2011
  4. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003
  5. ncbi Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 59:132-40. 2004
  6. ncbi Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain
    D Resnick
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:26924-30. 1996
  7. ncbi Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
  8. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
  9. ncbi Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA
    Gino V Limmon
    NIEHS NIH, Laboratory of Respiratory Biology, Durham, North Carolina 27709, USA
    FASEB J 22:159-67. 2008
  10. doi Conserved domains of the class A scavenger receptors: evolution and function
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 227:19-31. 2009

Research Grants

  1. Modifier genes of sepsis
    Antonio De Maio; Fiscal Year: 2009
  2. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
  3. Quantitative methods for genetic linkage heterogeneity
    Daniel Schaid; Fiscal Year: 2008
  4. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
  5. ETIOLOGIC HETEROGENEITY IN LATE ONSET BREAST CANCER
    Timothy Rebbeck; Fiscal Year: 2001
  6. AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"
    William Nelson; Fiscal Year: 2005
  7. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2007
  8. Mapping Prostate Cancer Susceptibility Genes at 8p22-23
    Jianfeng Xu; Fiscal Year: 2007
  9. Modifiers of Cancer Risk in BRCA 1/2 Mutation Carriers
    Timothy Rebbeck; Fiscal Year: 2008
  10. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010

Detail Information

Publications196 found, 100 shown here

  1. ncbi A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Lipid Res 39:531-43. 1998
    ..The demonstration that a naturally occurring splice variant of SR-A mRNA can act as a dominant negative isoform suggests a novel mechanism for regulation of scavenger receptor activity in macrophages...
  2. doi The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
    Celine Beauvillain
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Cancérologie Nantes Angers, Bâtiment Montéclair, 4 rue Larrey, Angers 49933, France
    J Hepatol 52:644-51. 2010
    ..This study aimed to identify the endocytic receptor(s) involved in the uptake of NS3 by myeloid cells and its relation with TLR2...
  3. doi Interleukin-10 down-regulates oxLDL induced expression of scavenger receptor A and Bak-1 in macrophages derived from THP-1 cells
    Hong Yang
    Tongji University School of Medicine, Shanghai 200092, China
    Arch Biochem Biophys 512:30-7. 2011
    ..Our findings suggested that IL-10 reduced the oxLDL-induced lipoprotein uptake and apoptosis partly via down-regulating the oxLDL-induced expression of SR-A and Bak-1 in THP-1-derived macrophages...
  4. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003
    Rare germline mutations of macrophage scavenger receptor 1 (MSR1) gene were reported to be associated with prostate cancer risk in families with hereditary prostate cancer (HPC) and in patients with non-HPC (Xu et al. 2002)...
  5. ncbi Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 59:132-40. 2004
    The macrophage scavenger receptor 1 (MSR1) gene on chromosome 8p22 was recently reported as a candidate gene for hereditary prostate cancer (HPC)...
  6. ncbi Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain
    D Resnick
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:26924-30. 1996
    ..The apparent juxtaposition of the fibrous domains at neutral pH provides a framework for future structure-function studies of these unusual multiligand receptors...
  7. ncbi Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in several processes proposed to be relevant to prostate ..
  8. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence...
  9. ncbi Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA
    Gino V Limmon
    NIEHS NIH, Laboratory of Respiratory Biology, Durham, North Carolina 27709, USA
    FASEB J 22:159-67. 2008
    ..These data provide direct evidence that SR-A is a novel cell surface receptor for dsRNA, and therefore, SR-A may play a role in antiviral immune responses...
  10. doi Conserved domains of the class A scavenger receptors: evolution and function
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 227:19-31. 2009
    ....
  11. doi Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells
    Kok Hooi Yew
    Pediatric Infectious Disease, Children s Mercy Hospitals, Kansas City, MO, United States
    Mol Immunol 47:883-93. 2010
    ..These findings reveal a novel mechanistic insight into an interrelationship between SR-A1 and TLR-3/-9 signaling in HCMV-exposed monocytes...
  12. pmc COPD is associated with a macrophage scavenger receptor-1 gene sequence variation
    Jill A Ohar
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 137:1098-107. 2010
    ..We genotyped at-risk smokers to evaluate the role of polymorphisms in the macrophage scavenger receptor-1 gene (MSR1) in COPD susceptibility and related measures of lung function...
  13. doi Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study
    M Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Intern Med 269:340-8. 2011
    The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates...
  14. doi Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma
    Manabu Shigeoka
    Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Sci 104:1112-9. 2013
    ..associated macrophages have anti-inflammatory properties or "alternatively" activated (M2) phenotype expressing CD204 and/or CD163...
  15. pmc Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions
    M Naito
    Second Department of Pathology, Kumamoto University Medical School, Japan
    Am J Pathol 141:591-9. 1992
    ..These results indicate that both type I and type II scavenger receptors are expressed and functionally active in physiologic and pathologic conditions...
  16. ncbi Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors
    J Ashkenas
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Lipid Res 34:983-1000. 1993
    ..5-12.8 micrograms protein/ml) affinity binding of 125I-labeled AcLDL. The ability of ReLPS (1 mg/ml) to inhibit either or both of these two classes of binding interactions varied depending on the species and type of receptor...
  17. ncbi Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains
    Ninetta Kosswig
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Biol Chem 278:34219-25. 2003
    ..Together, our results indicate a critical role for the membrane-proximal amino acids in SR-A trafficking and demonstrate that SR-A-mediated adhesion and internalization require distinct cytoplasmic domains...
  18. pmc Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6
    Xiaofei Yu
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 286:18795-806. 2011
    ..Here we report a previously unrecognized role of scavenger receptor A (SRA; also known as CD204) as a signaling regulator in the context of Toll-like receptor 4 (TLR4) activation...
  19. ncbi Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7
    V M Campa
    Instituto Universitario de Oncología del Principado de Asturias and Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33071 Oviedo, Spain
    Inflamm Res 54:328-37. 2005
    ..This study evaluates the poly inosinic acid (poly I)-induced activation in the murine monocytemacrophage cell line RAW 264.7, which led to an inflammatory phenotype...
  20. ncbi The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway
    Masako Mae
    Laboratory of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Kita, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:398-409. 2007
    ..FSL-1 induced upregulation of the expression of phagocytic receptors, including MSR1, CD36, DC-SIGN and Dectin-1 in THP-1 cells...
  21. ncbi Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, 901 87 Umea, Sweden
    Hum Genet 112:414-8. 2003
    ..In a recent study, seven potentially important mutations in the macrophage scavenger receptor 1 gene (MSR1), located at 8p22, were observed in families affected with HPC, and an indication of co-segregation between these ..
  22. ncbi Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells
    Yanyan Jiang
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX
    J Biol Chem 281:11834-45. 2006
    ..by the presence of a collagen-like domain and include macrophage scavenger receptor type A (SR-A1 I/II, SCARA1) and MARCO (SCARA2). These receptors are known to make important contributions to host defense...
  23. ncbi Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors
    J C Hu
    University of Texas School of Dentistry, Health Science Center at San Antonio, Department of Pediatric Dentistry, 78284 7888, USA
    Gene 251:1-8. 2000
    ..Repetitive DNA sequences from the MSR1 family are found in both the mouse and human PRSS17 genes...
  24. ncbi The complex genetic epidemiology of prostate cancer
    Daniel J Schaid
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hum Mol Genet 13:R103-21. 2004
    ..lead to refined mapping and mutation screening of several strong candidate genes, including ELAC2, RNASEL and MSR1. Up to now, a total of 10 genome-wide linkage scans for prostate cancer susceptibility have been completed, and are ..
  25. doi Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors
    Kyoko Kawamura
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 59:300-5. 2009
    ..Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors...
  26. doi Increased risk for atherosclerosis of various macrophage scavenger receptor 1 alleles
    Ronen Durst
    Department of Cardiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Genet Test Mol Biomarkers 13:583-7. 2009
    Macrophage scavenger receptor 1 (MSR1) mediates the uptake of modified low density lipoprotein (LDL)-cholesterol. The significance of MSR1 in atherosclerosis development in animal models is uncertain...
  27. doi Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus
    Jia Li
    Shanghai Institute of Rheumatology, Renji Hospital, Molecular Rheumatology Laboratory of Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 63:492-502. 2011
    ....
  28. doi Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology
    E Shantsila
    Haemostasis Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    J Thromb Haemost 9:1056-66. 2011
    ..Monocytes include several subsets with different and sometimes divergent roles in immunity, atherogenesis and reparative processes...
  29. doi [The role of the class A scavenger receptors, SR-A and MARCO, in the immune system. Part 2. Contribution to recognition and phagocytosis of pathogens as well as induction of immune response]
    Szczepan Jozefowski
    Katedra i Zakład Immunologii, Uniwersytet Jagiellonski, Collegium Medicum, ul Czysta 18, 31 121 Kraków
    Postepy Hig Med Dosw (Online) 66:120-31. 2012
    ..cells is mediated by pattern recognition receptors (PRR), which include the class A scavenger receptors (SR), SR-A/CD204 and MARCO...
  30. pmc Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
    Veerle Bieghs
    Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research NUTRIM Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands
    PLoS ONE 7:e34378. 2012
    ..demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), which are important for modified cholesterol-rich lipoprotein uptake, reduced NASH...
  31. doi Interaction of monocytes/macrophages with ovarian cancer cells promotes angiogenesis in vitro
    Xipeng Wang
    Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, China
    Cancer Sci 104:516-23. 2013
    ..THP-1 cells exhibited M2-polarized phenotype markers with high proportion of CD68(+) , CD206(+) and CD204(+) markers after phorbol 12-myristate 13-acetate (PMA) treatment, After co-culturing with TAM cells in a transwell ..
  32. pmc Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration
    Stefanie Haasken
    Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA
    J Immunol 191:1055-62. 2013
    The class A macrophage scavenger receptor Msr1 (SR-A, CD204) has been reported to participate in the maintenance of immunological tolerance. We investigated the role of Msr1 in a mouse model of autoantibody-dependent arthritis...
  33. doi Focused screening of a panel of cancer-related genetic polymorphisms reveals new susceptibility loci for pediatric acute lymphoblastic leukemia
    Sonja Offenmüller
    Pediatric Oncology and Hematology, University Children s Hospital, Erlangen, Germany
    Pediatr Blood Cancer 61:1411-5. 2014
    ..A genetic predisposition to acute lymphoblastic leukemia (ALL) in childhood is well established. Currently known risk loci, however, explain only one third of the estimated total risk related to common genetic variations...
  34. doi A novel subpopulation of peripheral blood mononuclear cells presents in major burn patients
    Hongbin Liu
    Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, 2D2 28 WMC, 8440 112 Street, Edmonton, AB, Canada T6G 2B7
    Burns 41:998-1007. 2015
    ..early stage following major thermal injuries, which primarily express procollagen 1, leukocyte specific protein 1, CD204, toll-like receptor 4 and stromal cell-derived factor 1 (SDF-1) receptor CXCR4...
  35. pmc SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation
    Linlin Yang
    Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America Pulmonary Immunology and Physiology Laboratory, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 10:e0126576. 2015
    ..Together, our findings support a model in which SP-R210 isoforms differentially regulate trafficking, expression, and activation of innate immune receptors on macrophages. ..
  36. doi miR-29a promotes scavenger receptor A expression by targeting QKI (quaking) during monocyte-macrophage differentiation
    Shuai Wang
    Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Biochem Biophys Res Commun 464:1-6. 2015
    Monocyte differentiation into macrophages results in upregulation of miR-29a and scavenger receptor A (SRA) expression, while the expression of RNA binding protein, QKI is suppressed...
  37. pmc Prognostic role of genetic biomarkers in clinical progression of prostate cancer
    María Jesús Alvarez-Cubero
    1 Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain 2 GENYO Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain
    Exp Mol Med 47:e176. 2015
    The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk ..
  38. pmc Characterization of the plant growth promoting bacterium, Enterobacter cloacae MSR1, isolated from roots of non-nodulating Medicago sativa
    Ashraf Y Z Khalifa
    Biological Sciences Department, College of Science, King Faisal University, Saudi Arabia Botany and Microbiology Department, Faculty of Science, University of Beni Suef, Beni Suef, Egypt
    Saudi J Biol Sci 23:79-86. 2016
    The aim of the present study was to characterize the endophytic bacterial strain designated MSR1 that was isolated from inside the non-nodulating roots of Medicago sativa after surface-sterilization...
  39. pmc Acute Exposure to Crystalline Silica Reduces Macrophage Activation in Response to Bacterial Lipoproteins
    Gillian L Beamer
    Department of Infectious Diseases and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
    Front Immunol 7:49. 2016
    ..Interestingly, these responses were dependent on interactions between SiO2 and the class A scavenger receptor CD204, but not MARCO...
  40. doi Transcriptional profiling of subcutaneous adipose tissue in Italian Large White pigs divergent for backfat thickness
    P Zambonelli
    Department of Agricultural and Food Sciences DISTAL, Bologna University, Via Fratelli Rosselli 107, 42123, Reggio Emilia, Italy
    Anim Genet 47:306-23. 2016
    ..g. ACP5, BCL2A1, CCR1, CD163, CD1A, EGR2, ENPP1, GPNMB, INHBB, LYZ, MSR1, OLR1, PIK3AP1, PLIN2, SPP1, SLC11A1, STC1) and 14 lower expressed (e.g...
  41. doi Depletion of Hepatic Macrophages Aggravates Liver Lesions Induced in Rats by Thioacetamide (TAA)
    Hossain M Golbar
    Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan
    Toxicol Pathol 44:246-58. 2016
    ..of differentiation [CD]68 and major histocompatibility complex class II) and M2 macrophages (expressing CD163 and CD204) mainly on days 1 through 3...
  42. doi Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis
    Takashi Ichimura
    Department of Chemotherapy, Gastroenterology Center, Gastroenterological Internal Medicine, the Cancer Institute Hospital of JFCR Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Hum Pathol 56:74-80. 2016
    Recent studies suggest that CD204-positive (CD204(+)) M2-type tumor-associated macrophages (TAMs) are associated with the aggressive behavior of various cancers...
  43. ncbi Mutational analysis of the macrophage scavenger receptor 1 (MSR1) gene in primary lung cancer
    Akinobu Yoshimura
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 71:99-104. 2004
    ..To facilitate investigation of alterations of the macrophage scavenger receptor 1 (MSR1), which is located on 8p22, and to determine the role of this gene in human carcinogenesis and tumor progression, ..
  44. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
    ..IL-13 deficiency led to decreased levels of alternatively activated CD206(+) and CD204(+) macrophages and increased levels of classically activated macrophages...
  45. pmc Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice
    Robert Drummond
    Department of Surgery, University of California San Diego, La Jolla, California 92093, USA
    J Surg Res 174:344-51. 2012
    ..Previous studies have shown that scavenger receptor A (Sra), also known as macrophage scavenger receptor 1 (Msr1), is a modifier of interleukin 10 (IL-10) expression after injection of bacterial lipopolysaccharide (LPS)...
  46. ncbi Genetic determinants of prostate cancer: a review
    Milan Kral
    Department of Urology, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 155:3-9. 2011
    ..associated with the risk of prostate cancer: changes in genes for the androgen receptor, RNAseL, ELAC2, MSR1, BRCA 1 and 2, HPCX, KLF6, HPC20 and fusion genes, e.g. TMPRSS2-ERG)...
  47. doi Differential gene expression in nerve biopsies of inflammatory neuropathies
    Andreas J Steck
    Department of Biomedicine Department of Neurology, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    J Peripher Nerv Syst 16:30-3. 2011
    ..A (CoA) desaturase, which may be a marker for remyelination, HLA-DQB1, CD69, an early T-cell activation gene, MSR1, a macrophage scavenger receptor, and PDZ and LIM domain 5 (PDLIM5), a factor regulating nuclear factor (NF)-kappa ..
  48. pmc Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity
    Huanfa Yi
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Cancer Res 71:6611-20. 2011
    ..The pattern recognition scavenger receptor SRA/CD204 attenuates the ability of DCs to activate CD8(+) T-cell responses...
  49. doi Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head
    Kiyoshi Yoshikawa
    Pathology Division, Research Center for Innovative Oncology, Kashiwa, Japan
    Cancer Sci 103:2012-20. 2012
    ..CD68 (a pan-macrophage marker) and CD204 (an M2 macrophage marker) immunohistochemistry was carried out in pancreas head specimens from 107 IDC cases and ..
  50. pmc Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction
    Gaetano Zizzo
    Section of Rheumatology, Department of Medicine, Temple University, Philadelphia, PA 19140, USA
    J Immunol 189:3508-20. 2012
    ..is heterogenous among macrophage subsets, being mostly restricted to anti-inflammatory M2c (CD14(+)CD16(+)CD163(+)CD204(+)CD206(+)CD209(-)) cells, differentiated by M-CSF or glucocorticoids...
  51. pmc Identification of an additional protein involved in mannan biosynthesis
    Yan Wang
    Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, MI, 48824, USA
    Plant J 73:105-17. 2013
    ..The level of mannosyl residues in stem glucomannans decreased by approximately 40% for Arabidopsis msr1 single T-DNA insertion mutants and by more than 50% for msr1 msr2 double mutants, but remained unchanged for msr2 ..
  52. pmc Macrophage heterogeneity and cholesterol homeostasis: classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL
    Eugene M Chu
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada V6Z 1Y6
    Biochim Biophys Acta 1831:378-86. 2013
    ..the mRNA expression of CD36 and the expression of both cell surface CD36 and macrophage scavenger receptor 1 (MSR1) protein...
  53. doi Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment
    Shunki Hirayama
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 7:1790-7. 2012
    ..b>CD204 (+) TAMs are reportedly related to tumor progression and clinical outcome in some tumors...
  54. doi Characterization of microglia/macrophages in gliomas developed in S-100β-v-erbB transgenic rats
    Atsushi Sasaki
    Department of Pathology, Saitama Medical University, Saitama
    Neuropathology 33:505-14. 2013
    ..Most TAMs showed no or little expression against CD68, CD163 or CD204, although CD204-positive TAMs were observed in necrosis as well as in the proliferating vascular wall...
  55. doi Lipoprotein lipase in non-small cell lung cancer tissue is highly expressed in a subpopulation of tumor-associated macrophages
    Helena Podgornik
    Department of Haematology, University Medical Centre Ljubljana, Zaloska cesta 2, 1000 Ljubljana, Slovenia
    Pathol Res Pract 209:516-20. 2013
    ..non-cancer tissue), expression of LPL correlated with expression of genes preferentially expressed in macrophages (MSR1, CD163, FOLR2), but not with expression of genes preferentially expressed in tumor cells...
  56. pmc CD4+ T cells and IFN-γ are required for the development of Pneumocystis-associated pulmonary hypertension
    Steve D Swain
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana Electronic address
    Am J Pathol 184:483-93. 2014
    ..Finally, we found differences in immune cell phenotypes that correlated with PH, including elevated CD204 expression in lung CD11c(+) cells, but their role remains unclear...
  57. pmc Pattern recognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis following organic dust extract exposures
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine
    J Immunotoxicol 12:64-73. 2015
    ..The multi-functional class A macrophage scavenger receptor (SRA)/CD204 has emerged as an important class of pattern recognition receptors with broad ligand binding ability...
  58. doi Prognostic significance of CD204-positive macrophages in upper urinary tract cancer
    Takashi Ichimura
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:2105-12. 2014
    Evidence suggests that CD204-positive (CD204(+)) tumor-infiltrating macrophages are associated with aggressive behavior of various cancers; however, the clinical, pathological, and prognostic associations of tumor-infiltrating CD204(+) ..
  59. pmc Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease
    Yoichiro Kaku
    Division of Respirology, Neurology, and Rheumatology, Department of Medicine 1, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    PLoS ONE 9:e87400. 2014
    ..Immunohistochemical techniques were used to examine CD163, CD204 and CD206, as M2 markers, expressed on alveolar macrophages in the lungs of patients with mild to very severe COPD ..
  60. pmc Host genetic variation influences gene expression response to rhinovirus infection
    Minal Caliskan
    Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 11:e1005111. 2015
    ..g., itga2, msr1, gstm3)...
  61. doi Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides
    Kariem Ezzat
    Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom
    Nano Lett 15:4364-73. 2015
    ..In vivo, the activity of PPMO was significantly decreased in SCARA1 knockout mice compared to wild-type animals...
  62. doi Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages
    Barbara Marengo
    Department of Experimental Medicine, University of Genoa, Via L B Alberti 2, Genoa, Italy
    Biofactors 42:80-92. 2016
    ..Compared with ethanol treatment, the oxysterol mixture decreased the surface expression of CD36 and CD204 scavenger receptors and reduced the amount of reactive oxygen species whereas it did not affect either cell ..
  63. doi Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells
    Le Ning Shao
    Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P R China
    Mol Med Rep 13:2661-70. 2016
    ..Expression of the cell surface markers CD68, CD204 and CD206, and changes to cell morphology were used to confirm successful differentiation...
  64. doi Mycobacterium bovis-infected macrophages from resistant and susceptible cattle exhibited a differential pro-inflammatory gene expression profile depending on strain virulence
    Edgar Alfonseca-Silva
    Laboratorio de Investigación en Tuberculosis Bovina, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Coyoacan, Mexico, D F 04510, Mexico
    Vet Immunol Immunopathol 176:34-43. 2016
    ..cytokine (TNFα, IL-12, IL-18, IL-1β, IL-6), chemokine (MCP-1, MCP-2, MIP-1), macrophage receptor (MSR1, TLR2, TLR4, MMR) and iNOS mRNA expression levels...
  65. pmc Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma
    Ken Hatogai
    Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan
    Oncotarget 7:47252-47264. 2016
    ..and TIICs, as well as infiltration of lymphocytes (CD4+, CD8+, FOXP3+, and PD- 1+) and macrophages (CD68+ and CD204+), were evaluated. PD-L1 was expressed in TCs of 18.4% and in TIICs of 83.3% of these patients...
  66. doi Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: Lesion staging and dynamic changes of axons and microglial subsets
    Kiyomitsu Oyanagi
    Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine, Nagano, Japan
    Brain Pathol . 2016
    ..Microglial cells immunopositive for CD68, CD163 or CD204 were far more obvious in ALSP, than in N-HD, and the shape and density of the cells changed in each stage...
  67. pmc Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
    Stefano Soldano
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
    PLoS ONE 11:e0166433. 2016
    ..are phenotypically characterized by the expression of specific markers, mainly macrophage scavenger receptors (CD204 and CD163) and mannose receptor-1 (CD206), and participate in the fibrotic process by over-producing pro-fibrotic ..
  68. ncbi Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson's Disease, Shifting M1 to M2 Microglia Responses
    Rosa Calvello
    Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, via Orabona, 4, 70126, Bari, Italy
    J Neuroimmune Pharmacol . 2016
    ..cytokines (IL-10, IL-4 and TGF-β) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2)...
  69. ncbi Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system
    Jens Husemann
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Glia 40:195-205. 2002
    Scavenger receptor class A (SR-A, CD204), scavenger receptor-BI (SR-BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologically modified substances, and participate in ..
  70. ncbi Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, Azienda Ospedaliera Umberto I, 60020 Torrette, Ancona, Italy
    Virchows Arch 444:503-8. 2004
    ..of PCa, mutations in a growing number of candidate hereditary prostate cancer loci and genes, such as RNASEL and MSR1, have been detected, suggesting that defects in critical pathways involving DNA damage response, apoptosis and ..
  71. doi Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice
    Taketoshi Kushiyama
    Department of Nephrology, National Defence Medical College, Tokorozawa, Saitama, Japan
    Nephrology (Carlton) 16:522-35. 2011
    ....
  72. doi The class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma
    Y Kato
    Laboratory of Veterinary Pathology, Life Science Research Centre, Gifu University, 1 1 Yanagido, Gifu, Japan
    J Comp Pathol 148:188-96. 2013
    The immunohistochemical expression of the class A macrophage scavenger receptor CD204, was investigated in 50 canine histiocytic sarcomas (HSs) and compared with that of CD18, CD163, CD11d and class II molecules of the major ..
  73. pmc Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-21
    Magomed Khaidakov
    Central Arkansas Veteran Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 7:e46973. 2012
    ..20 µg/ml ox-LDL for 2 and 12 hours was associated with upregulation of LOX-1 and CD36 scavenger receptors while MSR1 and CXLC16 receptors did not change...
  74. ncbi [Epidemiology and risk factors of the prostate cancer]
    Dominika Stasiewicz
    St John s Cancer Center, Lublin, Poland
    Pol Merkur Lekarski 33:163-7. 2012
    ..risk factors are advancing age, ethnicity and genetics, including changing in expression of ELAC2, RNASEL, MSR1 and HOXB13 genes as well as low number of CAG repeats in the androgen receptor gene...
  75. doi Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-γ
    Yao Dai
    University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72212, USA
    Biochem Biophys Res Commun 431:496-500. 2013
    ..the deficiency of LOX-1 modulates the expression of two other scavenger receptors, macrophage scavenger receptor-1 (MSR1) and CD36, on macrophages to account for the unaltered ox-LDL uptake...
  76. doi Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages
    Supriya R Hyam
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, Seoul 130 701, Republic of Korea
    Eur J Pharmacol 708:21-9. 2013
    ..IL-1β, IL-6 and TNF-α expression in LPS-stimulated peritoneal macrophages, but increased LPS-reduced IL-10 and CD204 expression...
  77. doi Nontuberculous mycobacteria-associated spindle cell pseudotumor of the nasal cavity: a case report
    Kentaro Ohara
    Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
    Pathol Int 63:266-71. 2013
    ..They were also positive for CD163 and CD204, suggesting that they showed a phenotype similar to alternatively activated (M2) macrophages and the phenotype ..
  78. doi GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways
    Naoki Urakawa
    1 Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan 2 Division of Gastro intestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Lab Invest 95:491-503. 2015
    ..of TE series human ESCC cell line (TECM) and confirmed the induction of the expression of the M2 macrophage marker CD204 and the protumorigenic factors interleukin (IL)-10, VEGFA, and MMPs...
  79. ncbi Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Sylvius Laboratories, Leiden University The Netherlands
    Arterioscler Thromb Vasc Biol 20:2600-6. 2000
    ..metabolism and atherogenesis was assessed in vivo by transplantation of bone marrow cells overexpressing human SRA (MSR1) to apoE-deficient mice...
  80. ncbi Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men
    David C Miller
    Department of Urology, University of Michigan, Medical School, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 63:3486-9. 2003
    Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors...
  81. pmc Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes
    Bin Hu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48105 2303, USA
    Am J Respir Cell Mol Biol 30:687-93. 2004
    ..Adhesion was not inhibited in either Mø type by mAbs against beta1 or beta3 integrins or scavenger receptor I/II (CD204), but AMø adhesion was inhibited by specific mAbs against CD11c/CD18...
  82. ncbi The role of inflammation in the pathogenesis of prostate cancer
    William G Nelson
    Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 172:S6-11; discussion S11-2. 2004
    ..A new hypothesis for the etiology of prostate cancer is that chronic or recurrent prostate inflammation may initiate and promote prostate cancer development...
  83. doi Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cancer Sci 100:2160-6. 2009
    Class A scavenger receptors (SR-A, CD204) are highly expressed in tumor-associated macrophages (TAM). To investigate the function of SR-A in TAM, wild-type and SR-A-deficient (SR-A(-/-)) mice were injected with EL4 cells...
  84. pmc Scavenger receptor A is expressed by macrophages in response to Porphyromonas gingivalis, and participates in TNF-alpha expression
    M T Baer
    Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Oral Microbiol Immunol 24:456-63. 2009
    ..Pattern recognition receptors (PRRs) participate in host response to this organism. It is likely that PRRs not previously recognized as part of the host response to P. gingivalis also participate in host response to this organism...
  85. pmc Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Clin Nutr 91:1574-83. 2010
    ..Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease...
  86. doi Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma
    Yoichi Ohtaki
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1507-15. 2010
    ..Alternatively, activated macrophages (M2 phenotype) are known to be related to tumor progression and outcome, and CD204 has been reported to be expressed in M2 macrophages in some tumors.
  87. doi Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation
    Daisuke Shiraishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Kumamoto, Japan
    Biochem Biophys Res Commun 425:304-8. 2012
    ..In addition, alternatively activated (M2) macrophage-related molecules, such as IL-10, CD163, and CD204 in HMDM, were significantly upregulated by GLP-1...
  88. doi Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma
    Kaoru Kaseda
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    Cancer Sci 104:1262-9. 2013
    ..004), whereas the expressions of CD44, CD44 variant 6, and vimentin were not. Large numbers of intravascular CD204(+) macrophages (P = 0.016), CD34(+) microvessels (P = 0.007), and α-smooth muscle actin (+) fibroblasts (P = 0...
  89. pmc Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization
    Fong Lee Huang
    Institute of Anatomy and Cell Biology, National Yang Ming University, Taipei11221, Taiwan
    J Biomed Sci 20:54. 2013
    ..Transfected COS-7 cells were incubated with fluorescent oAβ and acetylated LDL (AcLDL) to assess their ligand-internalization capabilities...
  90. doi Congenital cutaneous histiocytosis in a piglet
    P Helie
    Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Vet Pathol 51:812-5. 2014
    ..Immunohistochemically, the neoplastic cells were strongly positive for CD204; moderately positive for CD163, lysozyme, and vimentin; and negative for Mac 387, α-1-antitrypsin, S-100 protein ..
  91. pmc Spontaneous Extraskeletal Osteosarcoma in a Rabbit (Oryctolagus cuniculus): Histopathological and Immunohistochemical Findings
    Kavindra Kumara Wijesundera
    Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinku oraikita, Izumisano City, Osaka 598 8532, Japan
    J Toxicol Pathol 26:309-12. 2013
    ..the nature of osteoblasts with proliferating activity, but negative for α-smooth muscle actin, desmin or CD204. Based on these findings, a diagnosis of extraskeletal osteosarcoma was made, a very rare tumor both in laboratory ..
  92. doi Immunocytochemical detection of the class A macrophage scavenger receptor CD204 using air-dried cytologic smears of canine histiocytic sarcoma
    Yuki Kato
    Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
    Vet Clin Pathol 43:589-93. 2014
    ..Therefore, even on histopathologic examination, immunostaining is often necessary for a definitive diagnosis...
  93. ncbi A genomewide linkage analysis for prostate cancer susceptibility genes in families from Germany
    Christiane Maier
    Abteilung Humangenetik, Universitat Ulm, Germany
    Eur J Hum Genet 13:352-60. 2005
    ..47, P=0.0068), close to the previously identified susceptibility gene MSR1. Further local maxima with Zlr>2 (P<0.025) were observed at 1q, 5q and 15q...
  94. pmc Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Vascul Pharmacol 44:206-14. 2006
    ..Notably, the expression of VEGF-D, macrophage scavenger receptor-1 (MSR1), transforming growth factor beta receptor III (TGFbetaR3) and inhibitor of DNA binding 3 (ID3) was augmented by ..
  95. doi Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis
    Yuki Matsumura
    Pathology Division, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 103:1342-7. 2012
    ..respectively). Moreover, a significantly larger number of CD204-positive macrophages were present within the cancer-permeated lymphatic vessels in Type B patients than in Type A ..
  96. doi PKCδ signalling regulates SR-A and CD36 expression and foam cell formation
    Chin Sheng Lin
    Graduate Institute of Medical Science, National Defense Medical Center, No 161 Sec 6 Minquan E Rd, Neihu, Taipei, Taiwan, ROC
    Cardiovasc Res 95:346-55. 2012
    ..One of the critical steps in foam cell formation is the uptake of low-density lipoprotein (LDL) by macrophages via scavenger receptors (SRs). This study examined the role of protein kinase C (PKC) isoforms on foam cell formation...
  97. pmc In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancer
    Chunqing Guo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, PO Box 980033, Richmond, VA 23298, USA
    Mol Cancer Ther 11:2331-41. 2012
    ..radiation combined with in situ vaccination with DCs, in which the immunosuppressive scavenger receptor A (SRA/CD204) has been downregulated by lentivirus-mediated gene silencing, profoundly suppressed the growth of two mouse ..
  98. pmc Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study
    Magomed Khaidakov
    Central Arkansas Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    PLoS ONE 7:e47421. 2012
    ..is at least an order of magnitude greater than the expression of other major ox-LDL specific receptors CD36 and MSR1. In keeping with the data on LOX-1 expression, pre-treatment of HCAECs with LOX-1 neutralizing antibody resulted in ..
  99. doi CXCR4 positive and angiogenic monocytes in myocardial infarction
    Eduard Shantsila
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, UK
    Thromb Haemost 109:255-62. 2013
    ..001 for Mon1, p=0.02 for Mon2). CD204 expression on Mon1 correlated with tissue type plasminogen activator levels (r=0.46, p=0.001)...
  100. doi Slowly progressive cholangiofibrosis induced in rats by α-naphthylisothiocyanate (ANIT), with particular references to characteristics of macrophages and myofibroblasts
    Hossain M Golbar
    Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinku Ourai Kita, Izumisano City, Osaka 598 8531, Japan
    Exp Toxicol Pathol 65:825-35. 2013
    ..Interestingly, macrophages positive for SRA-E5 (CD204, reflecting lipid metabolism) increased at PFI weeks 7-19, and the appearance was limited in the sinusoids around ..
  101. pmc Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
    Y Ino
    Division of Molecular Pathology, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 108:914-23. 2013
    ..Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact...

Research Grants14

  1. Modifier genes of sepsis
    Antonio De Maio; Fiscal Year: 2009
    ..A candidate gene in this region, macrophage scavenger receptor 1 (Msr1), has emerged. The first aim of this investigation is to confirm the role of Msr1 during inflammation...
  2. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  3. Quantitative methods for genetic linkage heterogeneity
    Daniel Schaid; Fiscal Year: 2008
    ..Aim 3. User-friendly software: User-friendly software that implements the proposed methods, including well-documented procedures and examples of their usage, will be provided free to the scientific community. ..
  4. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
    ..The advantages of this proposed research, over those currently used to identify and characterize genes of complex diseases, are that it will offer a more powerful and flexible method to find these types of genes. ..
  5. ETIOLOGIC HETEROGENEITY IN LATE ONSET BREAST CANCER
    Timothy Rebbeck; Fiscal Year: 2001
    ..The results of these analyses will be used to attempt to elucidate the complex, multifactorial aetiology of late onset breast cancer. ..
  6. AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"
    William Nelson; Fiscal Year: 2005
    ..Support for this meeting will encourage the future development of urology research by providing mentoring for new investigators as well as education on this emerging research area. ..
  7. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2007
    ..abstract_text> ..
  8. Mapping Prostate Cancer Susceptibility Genes at 8p22-23
    Jianfeng Xu; Fiscal Year: 2007
    ..inversions, duplications) involving 8p22-23 in HPC patients; 3) the most recent finding by our group that the MSR1 (macrophage scavenger receptor 1) gene is associated with prostate cancer risk; and 4) evidence for additional ..
  9. Modifiers of Cancer Risk in BRCA 1/2 Mutation Carriers
    Timothy Rebbeck; Fiscal Year: 2008
    ..Our substantial multidisciplinary experience will therefore allow us to readily translate basic science and epidemiological data to clinically relevant information. ..
  10. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010
    ....
  11. Association of inflammatory genes and prostate cancer
    Jianfeng Xu; Fiscal Year: 2008
    ..Answers to these questions will significantly improve our knowledge of the role of inflammation in prostate cancer and will guide our efforts in identifying additional prostate cancer genes. ..
  12. Interaction of PTEN and CDKN1B in Pca susceptibility
    Jianfeng Xu; Fiscal Year: 2008
    ..The results from this study are likely to significant advance our knowledge of prostate cancer risk and begin to explore the underlying biological mechanisms for any observed differences. ..
  13. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2010
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
  14. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy R Rebbeck; Fiscal Year: 2010
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. ..