MRAS

Summary

Gene Symbol: MRAS
Description: muscle RAS oncogene homolog
Alias: M-RAs, R-RAS3, RRAS3, ras-related protein M-Ras, muscle and microspikes RAS, ras-related protein R-Ras3
Species: human

Top Publications

  1. ncbi Determination of quantitative food consumption levels for use in microbial risk assessments: cheddar cheese as an example
    Gyung Jin Bahk
    Department of Food Industry Development, Korea Health Industry Development Institute, Seoul 156 800, Korea
    J Food Prot 70:184-93. 2007
  2. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
  3. ncbi [Fabry disease in light of recent review]
    Eiichiro Uyama
    Department of Neurology, Kumamoto Takumadai Hospital, 1 14 27 Onoue, Kumamotoshi, Kumamoto 862 0913, Japan
    Brain Nerve 60:1235-44. 2008
  4. ncbi Traumatically induced vertebral artery occlusion associated with cervical spine injuries: prospective study using magnetic resonance angiography
    Hiroshi Taneichi
    Center for Spinal Disorder and Injury, Bibai Rosai Hospital, Bibai, Japan
    Spine (Phila Pa 1976) 30:1955-62. 2005
  5. doi Muscarinic receptor antagonism at the spinal cord level causes inhibitory effects on male rat sexual behavior
    Lisbeth E Gómez-Martínez
    Departamento de Recursos del Mar, CINVESTAV, Km 6, Carretera Antigua a Progreso, Cordemex 97310, A P 73, Merida, Yuc, Mexico
    Behav Brain Res 203:247-55. 2009
  6. doi M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras
    Etsuko Keduka
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Gene 429:49-58. 2009
  7. ncbi R-Ras3/(M-Ras) is involved in thermal adaptation in the critical period of thermal control establishment
    Galya Labunskay
    Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250 Israel
    J Neurobiol 66:56-70. 2006
  8. ncbi Mediator release assays based on human or murine immunoglobulin E in allergen standardization
    S Kaul
    Division of Allergology, Paul Ehrlich Institut, Langen, Germany
    Clin Exp Allergy 37:141-50. 2007
  9. doi Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Ann Neurol 67:648-56. 2010
  10. doi Incidence of unilateral distal vertebral artery aplasia: evaluation by combining basiparallel anatomic scanning-magnetic resonance imaging (BPAS-MRI) and magnetic resonance angiography
    Kohei Morimoto
    Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Jpn J Radiol 27:151-5. 2009

Research Grants

  1. Research for Adverse Drug-Events and Reports
    DENNIS PAUL WEST; Fiscal Year: 2010
  2. Sudha Seshadri; Fiscal Year: 2016
  3. Preeti Tandon; Fiscal Year: 2014
  4. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    HAL CHARLES; Fiscal Year: 1999
  5. R-RAS3 AND CELL SURVIVAL IN THE CENTRAL NERVOUS SYSTEM
    Andrew Chan; Fiscal Year: 2007
  6. Nanotube Reagentless Proteomic Arrays
    Michael Wilson; Fiscal Year: 2007
  7. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2001
  8. 3D Image Guided Endovascular Surgery
    Elizabeth Bullitt; Fiscal Year: 2006
  9. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2008
  10. Noninvasive assessment of tumor malignancy
    Elizabeth Bullitt; Fiscal Year: 2010

Detail Information

Publications167 found, 100 shown here

  1. ncbi Determination of quantitative food consumption levels for use in microbial risk assessments: cheddar cheese as an example
    Gyung Jin Bahk
    Department of Food Industry Development, Korea Health Industry Development Institute, Seoul 156 800, Korea
    J Food Prot 70:184-93. 2007
    ..it has been redesigned and that the data were sufficiently updated from previous versions to have more value for MRAs. We propose a model that can effectively use the new data sets and be incorporated into MRAs, using as an example ..
  2. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
    ..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24...
  3. ncbi [Fabry disease in light of recent review]
    Eiichiro Uyama
    Department of Neurology, Kumamoto Takumadai Hospital, 1 14 27 Onoue, Kumamotoshi, Kumamoto 862 0913, Japan
    Brain Nerve 60:1235-44. 2008
    ..In Caucasian patients, elongated, ectatic, and tortuous vertebral and basilar arteries are frequently observed on MRAs. Life-threatening megadolichobasilar anomaly with thrombosis has been identified in a large Hungarian family in ..
  4. ncbi Traumatically induced vertebral artery occlusion associated with cervical spine injuries: prospective study using magnetic resonance angiography
    Hiroshi Taneichi
    Center for Spinal Disorder and Injury, Bibai Rosai Hospital, Bibai, Japan
    Spine (Phila Pa 1976) 30:1955-62. 2005
    ..A prospective study using magnetic resonance angiography (MRA) on a consecutive cohort of patients with cervical spine injuries...
  5. doi Muscarinic receptor antagonism at the spinal cord level causes inhibitory effects on male rat sexual behavior
    Lisbeth E Gómez-Martínez
    Departamento de Recursos del Mar, CINVESTAV, Km 6, Carretera Antigua a Progreso, Cordemex 97310, A P 73, Merida, Yuc, Mexico
    Behav Brain Res 203:247-55. 2009
    ..In this study, the effects of the intrathecal (IT) administration of the muscarinic receptor antagonist subtypes (MRAs) methoctramine (Meth), tropicamide (Trop) and 4-DAMP on male rat sexual behavior were evaluated during three ..
  6. doi M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras
    Etsuko Keduka
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Gene 429:49-58. 2009
    ..By contrast, both the ascidians contain single genes orthologous to Mras, Rras, Ral, Rap1, and Rap2. A single Mras orthologue exists from nematode to mammalian...
  7. ncbi R-Ras3/(M-Ras) is involved in thermal adaptation in the critical period of thermal control establishment
    Galya Labunskay
    Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250 Israel
    J Neurobiol 66:56-70. 2006
    ..Taken together, the present findings correlate the R-Ras3-jun pathway with thermal-control establishment...
  8. ncbi Mediator release assays based on human or murine immunoglobulin E in allergen standardization
    S Kaul
    Division of Allergology, Paul Ehrlich Institut, Langen, Germany
    Clin Exp Allergy 37:141-50. 2007
    ..As established immunochemical methods in allergen standardization only determine inhibition potency or major allergen content, routine tests for biological potency may enhance standardization and batch control of allergen products...
  9. doi Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Ann Neurol 67:648-56. 2010
    ..To investigate the evolution and clinical significance of vasoconstriction on magnetic resonance angiography (MRA) in patients with reversible cerebral vasoconstriction syndromes (RCVS)...
  10. doi Incidence of unilateral distal vertebral artery aplasia: evaluation by combining basiparallel anatomic scanning-magnetic resonance imaging (BPAS-MRI) and magnetic resonance angiography
    Kohei Morimoto
    Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Jpn J Radiol 27:151-5. 2009
    ..During our daily magnetic resonance (MR) examinations, however, we frequently encounter MR angiograms (MRAs) that do not demonstrate unilateral VA...
  11. doi Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells
    Chin Mu Hsu
    School of Chinese Medicine, China Medical University, and Genetic Center, China Medical University Hospital, Taichung, Taiwan
    Biochem Biophys Res Commun 392:473-8. 2010
    ..The RNA expression levels of CYP1A1, CYP1B1, GDF15, SERPINE1, SOS1, RASD1, and MRAS were upregulated and those of NR1H4, PALMD, and TXNIP were downregulated in all three hepatoma cells...
  12. ncbi Catheter angiography, MR angiography, and MR perfusion in posterior reversible encephalopathy syndrome
    W S Bartynski
    Department of Radiology, Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 29:447-55. 2008
    ..The purpose of this study was to evaluate the catheter angiography (CA), MR angiography (MRA), and MR perfusion (MRP) features in PRES in order to render further insight into its mechanism of origin...
  13. ncbi Value of single-dose contrast-enhanced magnetic resonance angiography versus intraarterial digital subtraction angiography in therapy indications in abdominal and iliac arteries
    Philipp J Schaefer
    Department of Diagnostic Radiology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Strasse 9, 24105 Kiel, Germany
    Cardiovasc Intervent Radiol 30:376-82. 2007
    ..The results showed that the used MRA imaging technique of abdominal and iliac arteries is not competitive to i.a. DSA, with a high rate of misinterpretation of the MRAs resulting in incorrect therapies.
  14. pmc Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology
    Yasuhiro Saito
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    EMBO Rep 10:614-21. 2009
    ..Thus, we conclude that Plexin-B1 is a dual functional GAP for R-Ras and M-Ras, remodelling axon and dendrite morphology, respectively...
  15. ncbi Ras and relatives--job sharing and networking keep an old family together
    Annette Ehrhardt
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Exp Hematol 30:1089-106. 2002
    ..We also review the possibility that the differential localization of Ras proteins in different parts of the cell membrane may govern their responses to activation of cell surface receptors...
  16. ncbi MR arthrography of traumatic anterior shoulder lesions showed modest reproducibility and accuracy when evaluated under clinical circumstances
    S van Grinsven
    Department of Physiotherapy, Rijnstate Hospital, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands
    Arch Orthop Trauma Surg 127:11-7. 2007
    ..We examined the reproducibility and accuracy of high-field MRA in traumatic anterior shoulder instability under conditions resembling clinical practice and assessed the influence of observer experience...
  17. ncbi Dose comparison of single- vs. double-dose in contrast-enhanced magnetic resonance angiography of the carotid arteries: Intraindividual cross-over blinded trial using Gd-DTPA
    C Jourdan
    Department of Radiology, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Magn Reson Imaging 25:557-63. 2007
    ....
  18. doi 1.0-M gadobutrol versus 0.5-M gadoterate for peripheral magnetic resonance angiography: a prospective randomized controlled clinical trial
    Zsolt Szucs-Farkas
    Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University of Berne, Berne, Switzerland
    J Magn Reson Imaging 27:1399-405. 2008
    ..To perform a quantitative and qualitative comparison of gadobutrol and gadoterate in three-station contrast enhanced magnetic resonance angiography (CE-MRA) of the lower limbs...
  19. doi Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals
    Jae Sung Rhee
    Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul 133 791, South Korea
    Comp Biochem Physiol C Toxicol Pharmacol 149:433-9. 2009
    ..These results suggest that EDCs modulate the expression of R-ras genes and thus affect subsequent signal transduction and tumor development...
  20. doi Effectiveness of multidetector computed tomography arthrography for the diagnosis of shoulder pathology: comparison with magnetic resonance imaging with arthroscopic correlation
    Joo Han Oh
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea
    J Shoulder Elbow Surg 19:14-20. 2010
    ..We hypothesized that CTA would be cost-effective and effectively comparable with magnetic resonance arthrography (MRA) for assessing labral detachments and full-thickness rotator cuff tears...
  21. ncbi Intra-arterial magnetic resonance angiography of the iliac arteries: clinical experience using two different protocols
    C Paetzel
    Department of Diagnostic Radiology, University Hospital of Regensburg, Germany
    Acta Radiol 46:250-5. 2005
    ..To assess the feasibility of intra-arterial magnetic resonance angiography (iaMRA) with two different protocols...
  22. doi Time-resolved and high-resolution MRA in a rabbit model of pulmonary embolism at 7 T: preliminary results
    Jaime F Mata
    Department of Radiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Magn Reson Imaging 28:139-45. 2010
    ..Evaluate feasibility of using time-resolved and high-resolution, contrast-enhanced magnetic resonance angiography (MRA) at 7 T for characterization of an animal model of pulmonary embolism...
  23. pmc Effect of a titration polysomnogram on treatment success with a mandibular repositioning appliance
    Fernanda R Almeida
    Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada
    J Clin Sleep Med 5:198-204. 2009
    ..Titration of MRAs consists of sequential mandibular advancement guided by symptom improvement...
  24. doi Effects of omni-directional noise-exposure during hearing onset and age on auditory spatial resolution in the Mongolian gerbil (Meriones unguiculatus) -- a behavioral approach
    Julia K Maier
    Zoophysiology and Behaviour Group, Institute for Biology and Environmental Sciences, Carl von Ossietzky University Oldenburg, Carl von Ossietzky Street 9 11, 26129 Oldenburg, Germany
    Brain Res 1220:47-57. 2008
    ..b>MRAs for aged gerbils were higher compared to controls, whereas MRAs of noise-reared gerbils did not differ from those ..
  25. doi 3D TOF MRA of intracranial aneurysms at 1.5 T and 3 T: influence of matrix, parallel imaging, and acquisition time on image quality - a vascular phantom study
    Yasuhiro Hiai
    Department of Course of Radiological Sciences, Kumamoto University School of Health Sciences, Kumamoto University School of Medicine, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Acad Radiol 15:635-40. 2008
    ....
  26. ncbi CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I
    Jamila Louahed
    Ludwig Institute for Cancer Research, Brussels Branch, Experimental Medicine Unit, Universite de Louvain, Brussels, Belgium
    Eur J Immunol 33:494-501. 2003
    ..The implication of this pathway was confirmed by the fact that PD98059, an inhibitor of MEK kinases, as well as a dominant negative isoform of the M-RAS protein specifically blocked the anti-apoptotic activity of CCL1...
  27. ncbi Left ventricular end-diastolic volume is decreased at maximal exercise in athletes with marked repolarisation abnormalities: a continuous radionuclide monitoring study
    Albert Flotats
    Department of Nuclear Medicine, Hospital de la Santa Creu i Sant Pau, Sant Antoni M Claret, 167, 08025, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 32:203-10. 2005
    Although marked repolarisation abnormalities (MRAs) are considered innocuous in trained athletes, their functional significance awaits clarification...
  28. ncbi Long-term effects of mandibular repositioning appliances on symptoms of sleep apnoea
    Marie Marklund
    Department of Orthodontics, University Hospital, Umea, Sweden
    J Sleep Res 16:414-20. 2007
    Mandibular repositioning appliances (MRAs) reduce symptoms of obstructive sleep apnoea in the short term, but the long-term effects are unknown...
  29. doi MR angiographic follow-up of intracranial aneurysms treated with detachable coils: evaluation of a blood-pool contrast medium
    T Kau
    Institute of Diagnostic and Interventional Radiology, St Veiter Strasse 47, Klagenfurt, Austria
    AJNR Am J Neuroradiol 30:1524-30. 2009
    ..Our aim was to compare blood-pool contrast-enhanced MR angiography (BPCE-MRA) using gadofosveset trisodium (Vasovist) with 3D time-of-flight MRA (TOF-MRA) in the follow-up of intracranial aneurysms after endovascular therapy...
  30. ncbi Nutrition, acid-base status and growth in early childhood
    H Kalhoff
    Pediatric Clinic, Dortmund, Germany
    Eur J Nutr 40:221-30. 2001
    ..an early stage during the development of retention acidosis, characterized by maximum renal acid stimulation (MRAS, urine-pH < 5.4) on two consecutive days but still compensated systemic acid-base status...
  31. ncbi Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor
    Kai Xin Zhang
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Cancer Res 2:242-55. 2004
    ..Autocrine HGF/SF was thus critical for expression of key features of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras...
  32. ncbi Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells
    Peng Sun
    Department of Biology, Faculty of Science, and Graduate School of Science and Technology, Chiba University, Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Genes Cells 11:1097-113. 2006
    ..Therefore, M-Ras is essential for neuronal differentiation in PC12 cells by inducing sustained activation of ERK pathway...
  33. doi Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease
    R Pisoni
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Hum Hypertens 26:502-6. 2012
    ..Mineralocorticoid receptor antagonists (MRAs) are effective in the management of resistant hypertension but are not widely used in CKD because of the risk of ..
  34. doi The role of mineralocorticoid receptor antagonists in patients with American College of Cardiology/American Heart Association stage B heart failure
    Bertram Pitt
    Cardiovascular Center, University Hospital, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5853, USA
    Heart Fail Clin 8:247-53. 2012
    This article focuses on the potential role of mineralocorticoid receptor antagonists (MRAs) in patients with stage B heart failure (HF) due to hypertension, diabetes mellitus, and/or visceral obesity with the metabolic syndrome...
  35. doi Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells
    Lucilene Delazari Dos Santos
    Center for the Study of Venoms and Venomous Animals, University of Sao Paulo State, Botucatu, SP, Brazil
    Proteomics 12:2682-93. 2012
    ..The identification of the five proteins as targets of mastoparans may contribute in the near future to the use of this family of peptides as novel tools for dissecting the mechanism of exocytosis in mast cells...
  36. doi Study of aldosterone synthase inhibition as an add-on therapy in resistant hypertension
    Adam D Karns
    A Medical Corporation, Beverly Hills, CA, USA
    J Clin Hypertens (Greenwich) 15:186-92. 2013
    Aldosterone inhibition with mineralcorticoid receptor antagonists (MRAs) is an effective treatment for resistant hypertension...
  37. pmc Role of diuretics and ultrafiltration in congestive heart failure
    Dmitry Shchekochikhin
    University of Colorado Division of Renal Diseases and Hypertension, 12700 East 19th Avenue, C281, Aurora, CO 80045, USA
    Pharmaceuticals (Basel) 6:851-66. 2013
    ..addition of distal acting thiazide diuretics, natriuretic doses of mineralocorticoid receptor antagonists (MRAs), or vasoactive drugs. Slow continuous veno-venous ultrafiltration is another option...
  38. doi Diuretics in the treatment of hypertension. Part 2: loop diuretics and potassium-sparing agents
    Juan Tamargo
    Universidad Complutense, School of Medicine, Department of Pharmacology, Madrid, Spain
    Expert Opin Pharmacother 15:605-21. 2014
    ..Diuretics enhance the renal excretion of Na(+) and water due to a direct action at different tubular sites of the nephron where solute re-absorption occurs...
  39. pmc A Novel SHOC2 Variant in Rasopathy
    Vickie Hannig
    Division of Medical Genetics and Genomic Medicine, Vanderbilt University, Nashville, Tennessee
    Hum Mutat 35:1290-4. 2014
    ..We conclude that SHOC2 mutations can cause a spectrum of Rasopathy phenotypes in heterozygous individuals. Importantly, our work suggests that individuals with mild Rasopathy symptoms may be underdiagnosed. ..
  40. doi Galectin-3 and heart failure: prognosis, prediction & clinical utility
    Mando D Filipe
    University of Groningen, University Medical Center Groningen, Department of Cardiology, The Netherlands
    Clin Chim Acta 443:48-56. 2015
    ..enzyme (ACE) inhibitors, β-blockers, angiotensin receptor blockers (ARBs), mineralocorticoid receptor antagonists (MRAs), and implantable cardiac defibrillators, prognosis of HF patients remains poor...
  41. doi Heart failure with preserved ejection fraction
    Pierpaolo Pellicori
    Department of Cardiology, Hull York Medical School, Hull, UK
    Clin Med (Lond) 14:s22-8. 2014
    ..treatments directed at congestion and hypertension, such as diuretics, mineralocorticoid receptor antagonists (MRAs) and angiotensin converting-enzyme inhibitors, may improve symptoms and probably do improve outcomes...
  42. doi Stress-induced Aldosterone Hyper-Secretion in a Substantial Subset of Patients With Essential Hypertension
    Athina Markou
    Department of Endocrinology and Diabetes Center A M, I I A, C M T P, A G, L P, S F, D R, G P P, G Gennimatas General Hospital, Athens 11527, Greece Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics A S, E C, G P C, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece Department of Pathophysiology G K, University of Athens Medical School, Laikon Hospital, Athens 11527, Greece and Department of Cardiology A Z, A K, G Gennimatas General Hospital, Athens 11527, Greece
    J Clin Endocrinol Metab 100:2857-64. 2015
    ..Mineralocorticoid receptor antagonists (MRAs) have effectively been used for the treatment of patients with hypertension who do not have primary aldosteronism (..
  43. pmc Comparative Effectiveness and Safety of Monodrug Therapies for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Network Meta-analysis
    Jin Qiu Yuan
    From the Division of Epidemiology, School of Public Health and Primary Care JY, CM, ZY, XF, JT Department of Community and Family Medicine, The Chinese University of Hong Kong SW Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, Guangdong Province JY, CM, ZY, XF, JT and Kidney Internal Medical Department, Mianyang Central Hospital, Mianyang, China XD
    Medicine (Baltimore) 94:e974. 2015
    ..controlled trials that compared α-blockers, 5-alpha reductase inhibitors (5ARIs), muscarinic receptor antagonists (MRAs), phosphodiesterase-5 inhibitor (PDE5-Is), or placebo for the treatment of BPH...
  44. doi Spironolactone for Management of Heart Failure with Preserved Ejection Fraction: Whither to After TOPCAT?
    Sumeet S Mitter
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 600, Chicago, IL, 60611, USA
    Curr Atheroscler Rep 17:64. 2015
    Mineralocorticoid receptor antagonists (MRAs) represent an attractive class of drugs for the treatment of heart failure with preserved ejection fraction (HFpEF) because of the deleterious cardiovascular effects of aldosterone and because ..
  45. pmc Absence of M-Ras modulates social behavior in mice
    Annette Ehrhardt
    The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, V6T 1Z3, Canada
    BMC Neurosci 16:68. 2015
    ..Here, we report that the absence of the small GTPase M-Ras affects social behavior in mice...
  46. doi The association of nurse practitioners' mortality risk assessments and advance care planning discussions on nursing home patients' clinical outcomes
    Susan E Mullaney
    School of Nursing, College of Health Sciences, University of Massachusetts Lowell, Lowell, Massachusetts
    J Am Assoc Nurse Pract 28:304-10. 2016
    To investigate the impact nurse practitioners' (NPs) documented mortality risk assessments (MRAs) and advance care planning (ACP) discussions have on clinical outcomes for newly enrolled Medicare Advantage nursing home patients.
  47. pmc Temporal Trends and Hospital Variation in Mineralocorticoid Receptor Antagonist Use in Veterans Discharged With Heart Failure
    Sandesh Dev
    Phoenix VA Medical Center, Phoenix, AZ S D
    J Am Heart Assoc 4:. 2015
    Despite concerns about mineralocorticoid receptor antagonist therapies (MRAs) underuse and misuse in patients with heart failure, temporal and institutional variations of MRA prescription have not been reported.
  48. doi Use of a semi-automated cardiac segmentation tool improves reproducibility and speed of segmentation of contaminated right heart magnetic resonance angiography
    Animesh Tandon
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cardiovasc Imaging 32:1273-9. 2016
    ..Magnetic resonance angiograms (MRAs) of 19 patients undergoing intervention for right ventricular outflow lesions were segmented to demonstrate the ..
  49. doi A Single-Nucleotide Polymorphism in C12orf43 Region is Associated with the Risk of Coronary Artery Disease in a Pakistani Cohort
    Shafiqa Shahzadi
    Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
    Biochem Genet 54:676-84. 2016
    ..We aimed to examine the association of MRAS/rs9818870 and C12orf43/rs2258287 polymorphisms with the risk of CAD in a Pakistani sample...
  50. ncbi Purification of Antibacterial CHAPK Protein Using a Self-Cleaving Fusion Tag and Its Activity Against Methicillin-Resistant Staphylococcus aureus
    Elahe Seyed Hosseini
    Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
    Probiotics Antimicrob Proteins 8:202-210. 2016
    ..Finally, inhibition zone in MRAS culture medium confirmed antibacterial activity of the protein...
  51. pmc Expression of myogenes in longissimus dorsi muscle during prenatal development in commercial and local Piau pigs
    Evelyze Pinheiro Dos Reis
    Departamento de Zootecnia, Universidade Federal de Viçosa UFV, Vicosa, MG, Brazil
    Genet Mol Biol 39:589-599. 2016
    ..Pair-wise comparisons of prenatal periods in each breed showed that only the CSRP3, LEF1, MRAS and MYOG genes had higher expression (p < 0.05) in at least one prenatal period in commercial and Piau pigs...
  52. pmc Mineralocorticoid receptor antagonists for heart failure: systematic review and meta-analysis
    Nicolas M Berbenetz
    Department of Medicine, Western University, 339 Windermere Road, London, ON, N6A 5A5, Canada
    BMC Cardiovasc Disord 16:246. 2016
    Mineralocorticoid receptor antagonists (MRAs) have been associated with improved patient outcomes in patients with heart failure with reduced ejection fraction (HFrEF) but not preserved ejection fraction (HFpEF)...
  53. ncbi Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases
    Min Ye
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 280:31267-75. 2005
    ..Further, the first determination of the state 1 structure provides a molecular basis for developing novel anti-cancer drugs as compounds that hold Ras in the state 1 "off" conformation...
  54. ncbi Use of microbial risk assessment to inform the national estimate of acute gastrointestinal illness attributable to microbes in drinking water
    Jeffrey A Soller
    Soller Environmental, 3022 King St, Berkeley, CA 94703, USA
    J Water Health 4:165-86. 2006
    ..Pathogen-specific MRAS could be developed to characterize the risk associated with each of these components; however, these assessments ..
  55. ncbi Implant-retained oral appliances: a novel treatment for edentulous patients with obstructive sleep apnea-hypopnea syndrome
    Aarnoud Hoekema
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Oral Implants Res 18:383-7. 2007
    Mandibular repositioning appliances (MRAs) are a viable treatment alternative in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS)...
  56. doi M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation
    Haruko Watanabe-Takano
    Department of Biology, Graduate School of Science, Chiba University, Inageku, Chiba 263 8522, Japan
    Exp Cell Res 316:477-90. 2010
    ..These results imply that M-Ras, induced and activated by BMP-2 signaling, participates in the osteoblastic determination, differentiation, and transdifferentiation under p38 MAPK and JNK regulation...
  57. pmc Cervical vascular and upper airway asymmetry in Velo-cardio-facial syndrome: correlation of nasopharyngoscopy with MRA
    Avi G Oppenheimer
    Department of Radiology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, United States
    Int J Pediatr Otorhinolaryngol 74:619-25. 2010
    ..Furthermore, we assess the relationship with respect to laterality between cervical vascular patterns and the asymmetric abnormalities of these subjects' upper airways...
  58. pmc Successful Management of Pregnancy Complicated by Klippel-Trenaunay Syndrome Using MR Angiography-Based Evaluation
    Reiko Tanaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Case Rep Obstet Gynecol 2011:723467. 2011
    ..Systematic MRAs revealed hemangiomas and varicosities in the right leg, the lower abdomen, and the pubic region, while no obvious ..
  59. doi Selection of a mineralocorticoid receptor antagonist for patients with hypertension or heart failure
    Javaid Iqbal
    Department of Cardiovascular Science at the University of Sheffield and Cardiology Department at Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
    Eur J Heart Fail 16:143-50. 2014
    Clinical trials have demonstrated morbidity and mortality benefits of mineralocorticoid receptor antagonists (MRAs) in patients with heart failure. These studies have used either spironolactone or eplerenone as the MRA...
  60. pmc Mineralocorticoid receptor antagonist use in hospitalized patients with heart failure, reduced ejection fraction, and diabetes mellitus (from the EVEREST Trial)
    Muthiah Vaduganathan
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Am J Cardiol 114:743-50. 2014
    Despite the well-established benefits of mineralocorticoid receptor agonists (MRAs) in heart failure with reduced ejection fraction, safety concerns remain in patients with concomitant diabetes mellitus (DM) because of common renal and ..
  61. doi Clinical Outcomes in Dialysis Patients: Prospects for Improvement with Aldosterone Receptor Antagonists
    Samantha Dias Suthar
    Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina
    Semin Dial 29:52-61. 2016
    ..Therapy with mineralocorticoid receptor antagonists (MRAs) effectively reduces cardiac risk in discrete populations...
  62. pmc Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression
    Khairy M A Zoheir
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University P O Box 2457, Riyadh, Saudi Arabia Department of Cell Biology, National Research Centre 12622 Cairo, Egypt
    Int J Clin Exp Pathol 8:8821-31. 2015
    ..The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice...
  63. doi Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?
    L A Sechi
    Internal Medicine, Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy
    Horm Metab Res 47:1000-6. 2015
    ..Treatment with mineralocorticoid receptor antagonists (MRAs) is currently recommended for PA patients with bilateral adrenal disease, but these agents effectively decrease ..
  64. doi Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study
    Ken Lee Chin
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Eur J Heart Fail 18:1175-81. 2016
    ..concomitant use of aspirin might attenuate the beneficial effects of mineralocorticoid receptor antagonists (MRAs)...
  65. doi Vascular Effects of Eplerenone in Coronary Artery Disease With Preserved Ejection Fraction: A Double-Blind, Randomized, Placebo-Controlled Trial
    Isabella Sudano
    University Heart Center, Cardiology Clinic, University Hospital Zurich, Zurich, Switzerland
    Clin Cardiol 39:285-90. 2016
    Mineralocorticoid receptor antagonists (MRAs) reduce morbidity and mortality in heart failure with reduced ejection fraction (HFrEF)...
  66. doi Global cardiovascular protection in chronic kidney disease
    Gema Ruiz-Hurtado
    Unidad de Hipertensión and Instituto de Investigación i 12, Hospital Universitario 12 de Octubre, Avenida de Cordoba s n, 28041 Madrid, Spain
    Nat Rev Cardiol 13:603-8. 2016
    ..angiotensin-converting-enzyme inhibitors, angiotensin-receptor blockers, or mineralocorticoid-receptor antagonists (MRAs) often do not experience complete blockade of the renin-angiotensin-aldosterone system, primarily owing to the risk ..
  67. ncbi Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1
    Matthieu Collin
    a Intellectual Property Department, INSERM Transfert, Paris, France
    Expert Opin Ther Pat . 2016
    ..Beyond cardiac diseases, new indications of MRAs increase exponentially, especially in patients with impaired renal function...
  68. ncbi Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
    Jinbo Yang
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer Res 65:939-47. 2005
    ..g., MRAS and MET)...
  69. ncbi Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras
    Xuecui Guo
    The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z3
    Oncogene 24:2330-42. 2005
    ..Thus, expression of either activated M-Ras or H-Ras in normal hematopoietic cells was sufficient for transformation but each resulted in the generation of distinct lineages of cells...
  70. ncbi Expression of activated M-Ras in hemopoietic stem cells initiates leukemogenic transformation, immortalization and preferential generation of mast cells
    X Guo
    The Biomedical Research Centre, The University of British Columbia, Vancouver, BC, Canada
    Oncogene 25:4241-4. 2006
    ....
  71. doi Phase contrast and time-of-flight magnetic resonance angiography of the intracerebral arteries at 1.5, 3 and 7 T
    Anna C Stamm
    Department of Diagnostic Radiology, Philipps University, Marburg, Germany
    Magn Reson Imaging 31:545-9. 2013
    Time-of-flight (ToF) and phase contrast (PC) magnetic resonance angiographies (MRAs) are noninvasive applications to depict the cerebral arteries...
  72. pmc Increased constrictor tone induced by ouabain treatment in rats
    Victor M Pulgar
    Biomedical Research Infrastructure Center, Winston Salem State University, Winston Salem, NC 27101, USA
    J Cardiovasc Pharmacol 62:174-83. 2013
    ..At the end of treatment, vascular responses were studied in mesenteric resistance arteries (MRAs) by wire myography...
  73. pmc In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
    Fumi Shima
    Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Proc Natl Acad Sci U S A 110:8182-7. 2013
    ....
  74. doi Characterization of the enzymatic activity of Clostridium perfringens TpeL
    Serge Pauillac
    Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Toxicon 75:136-43. 2013
    ..In contrast to previous report, we observed that Ral was not a substrate of TpeL. In addition, we confirmed by in vitro glucosylation and mass spectrometry that TpeL modifies cH-Ras at Thr35...
  75. pmc Potential biomarkers for paclitaxel sensitivity in hypopharynx cancer cell
    Cheng zhi Xu
    Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, China
    Int J Clin Exp Pathol 6:2745-56. 2013
    ..interferon signaling (IFIT1, IFIT3, IFITM1 and MX1 etc.), mTOR signaling (MRAS, PRKAA2, PLD1, RND3 and EIF4A1 etc.) and IGF1 signaling (MRAS, IGFBP7, JUN and FOS etc...
  76. ncbi Identification of protein-protein interactions using in vivo cross-linking and mass spectrometry
    Julian Vasilescu
    The Biomedical Research Centre, University of British Columbia, Vancouver, Canada
    Proteomics 4:3845-54. 2004
    ..Among these, we identified the RasGAP-related protein IQGAP1 to be a novel interaction partner of M-Ras(Q71L). This method is applicable to many proteins and will aid in the study of protein-protein interactions...
  77. ncbi Resolution in azimuth sound localization in the Mongolian gerbil (Meriones unguiculatus)
    Julia K Maier
    Zoophysiology and Behavior Group, Institute for Biology and Environmental Science, Carl von Ossietzky University, Postfach 2503, 26111 Oldenburg, Germany
    J Acoust Soc Am 119:1029-36. 2006
    Minimum resolvable angles (MRAs) for sound localization in azimuth in the gerbil were determined in a behavioral study using tones, 300-Hz bands of noise centered at frequencies between 500 Hz and 8 kHz and broad-band noise of on average ..
  78. ncbi The COOH-terminal end of R-Ras alters the motility and morphology of breast epithelial cells through Rho/Rho-kinase
    Ha Won Jeong
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Daegu, Korea
    Cancer Res 65:507-15. 2005
    ..Our results suggest that R-Ras in breast epithelial cells disrupts cell polarity and motility through the Rho/Rho-associated kinase pathway triggered by a signal from the COOH-terminal end of R-Ras...
  79. ncbi Measuring Ras-family GTP levels in vivo--running hot and cold
    Ariel F Castro
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Walther Cancer Institute, Indianapolis, IN 46202, USA
    Methods 37:190-6. 2005
    ..Here we describe the detection of M-Ras and Rap1 activity by GST-RBD pull-down as well as that of Rheb and epitope-tagged R-Ras by classical metabolic labeling and immunoprecipitation...
  80. doi Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure
    Miriam T Rademaker
    Christchurch Heart Institute, Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand
    Circ Heart Fail 6:825-32. 2013
    Mineralocorticoid receptor antagonists (MRAs) have become established therapy in heart failure (HF). Urocortin 2 (Ucn2) is a novel peptide with potential in the treatment of this disease...
  81. ncbi Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases
    Won Do Heo
    Department of Molecular Pharmacology, Stanford University School of Medicine, 269 Campus Drive, Room 3215, Stanford, CA 94305, USA
    Cell 113:315-28. 2003
    ..Our study shows that specificity in protein families can be explored by combining genome-wide experimental functional classification with the creation of switch-of-function mutants...
  82. ncbi Reconstruction and in silico analysis of the MAPK signaling pathways in the human blood fluke, Schistosoma japonicum
    Lili Wang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, PR China
    FEBS Lett 580:3677-86. 2006
    ..In addition, several pathway member genes, including ERK, JNK, Sja-DSP, MRAS and RAS, were determined through quantitative PCR analysis to be expressed in a stage-specific manner, with ERK, ..
  83. doi Mineralocorticoid receptor antagonists for therapy of coronary artery disease and related complications
    Carolin Zwadlo
    Department of Cardiology and Angiology, Hannover Medical School, Germany
    Curr Opin Pharmacol 13:280-6. 2013
    ..Mineralocorticoid receptor antagonists (MRAs), such as spironolactone and eplerenone, prevent some of these maladaptive effects on the cardiovascular system and ..
  84. pmc New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3
    Maie Alshahid
    King Faisal Heart Institute, MBC 16, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Hum Genomics 7:15. 2013
    The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function as signal transducers in multiple processes including cell growth and differentiation...
  85. doi MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate
    Marie Emmanuelle Mathieu
    University of Bordeaux, CIRID, UMR 5164, F 33000 Bordeaux, France
    Development 140:3311-22. 2013
    ..Here we focus on muscle ras oncogene homolog (MRAS), which is a small GTPase of the Ras family encoded within the Pluri gene cluster...
  86. ncbi Gadolinium-enhanced versus time-of-flight magnetic resonance angiography: what is the benefit of contrast enhancement in evaluating carotid stenosis?
    Bart E Muhs
    Division of Vascular Surgery, New York University School of Medicine, New York, NY 10016, USA
    Ann Vasc Surg 19:823-8. 2005
    ..This was accomplished in 79.1% (136/172) of all GE MRAs. Simultaneous aortic arch imaging was not technically feasible with TOF MRA...
  87. doi Expanding role of mineralocorticoid receptor antagonists in the treatment of heart failure
    Alidz Talatinian
    College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, USA
    Pharmacotherapy 32:827-37. 2012
    ..Mineralocorticoid receptor antagonists (MRAs) have also demonstrated significant benefits in the treatment of heart failure, which include a reduction in sudden ..
  88. doi Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension
    Gianluca Colussi
    Clinica Medica, Department of Experimental and Clinical Medicine, University of Udine, Udine, Italy
    J Hypertens 31:3-15. 2013
    Mineralocorticoid receptor antagonists (MRAs) are commonly used to reduce blood pressure, left-ventricular hypertrophy, and urinary albumin excretion in patients with essential hypertension or primary aldosteronism...
  89. doi Management of hyperkalaemia consequent to mineralocorticoid-receptor antagonist therapy
    Sara S Roscioni
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands
    Nat Rev Nephrol 8:691-9. 2012
    Mineralocorticoid-receptor antagonists (MRAs) reduce blood pressure and albuminuria in patients treated with angiotensin-converting-enzyme inhibitors or angiotensin-II-receptor blockers...
  90. doi Targeting the renin-angiotensin-aldosterone system in heart failure
    Chim C Lang
    Division of Cardiovascular and Diabetes Medicine, Mailbox 2, Ninewells Hospital and Medical School, Medical Research Institute, University of Dundee, Dundee DD1 9SY, UK
    Nat Rev Cardiol 10:125-34. 2013
    ..enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)--and new data continue to emerge...
  91. pmc Effects of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with left ventricular systolic dysfunction: a meta-analysis of randomized controlled trials
    Srinivas R Bapoje
    Department of Medicine, Denver Health and Hospital Authority, Denver, CO, USA
    Circ Heart Fail 6:166-73. 2013
    ..Mineralocorticoid receptor antagonists (MRAs) may attenuate this risk...
  92. ncbi The new technique of using the epigastric arteries in renal transplantation with multiple renal arteries
    Mohammad Ali Amirzargar
    Department of Urology, Hamadan University of Medical Sciences, Hamadan, Iran
    Saudi J Kidney Dis Transpl 24:247-53. 2013
    ..We describe the long-term outcomes of 16 years of experience in 76 kidney transplantations with MRAs. In a new reconstruction technique, we remove arterial clamps after anastomosing the donor to the recipient's main ..
  93. doi The role of mineralocorticoid receptor antagonists (MRAs) in very old patients with heart failure
    Bertram Pitt
    School of Medicine, University of Michigan, Ann Arbor, MI, USA
    Heart Fail Rev 17:573-9. 2012
    Mineralocorticoid receptor antagonists (MRAs) have been effective in reducing total mortality in patients with heart failure (HF) and a reduced left ventricular ejection fraction...
  94. doi Update on aldosterone antagonists use in heart failure with reduced left ventricular ejection fraction. Heart Failure Society of America Guidelines Committee
    Javed Butler
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA
    J Card Fail 18:265-81. 2012
    Aldosterone antagonists (or mineralocorticoid receptor antagonists [MRAs]) are guideline-recommended therapy for patients with moderate to severe heart failure (HF) symptoms and reduced left ventricular ejection fraction (LVEF), and in ..
  95. doi Comparison of the quality of lower limb magnetic resonance angiographies performed with different paramagnetic contrast agents in relation to body mass index and ejection fraction
    Lukas Hrdina
    Department of Radiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 156:164-70. 2012
    To compare the quality of magnetic resonance angiographies (MRAs) performed with different contrast agents and to evaluate the effect of body mass index (BMI) and ejection fraction (EF) on the quality of these MRAs.
  96. ncbi Genetic and functional analyses of MRAS and HNF1A genes in diabetes and diabetic nephropathy
    E Horová
    Third Department of Medicine Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
    Folia Biol (Praha) 58:121-7. 2012
    Evidence has recently indicated that the MRAS and HNF1A genetic polymorphisms are associated with coronary artery disease...
  97. doi Current opinions and clinical practice in the titration of oral appliances in the treatment of sleep-disordered breathing
    Marijke Dieltjens
    Clinical Department of Special Care Dentistry, University of Antwerp UA and Antwerp University Hospital UZA, Edegem, Antwerp, Belgium
    Sleep Med Rev 16:177-85. 2012
    ..Mandibular repositioning appliances (MRAs) which are worn intra-orally at night, mechanically advance the mandible to help maintain a patent oropharygeal ..
  98. ncbi STAR MR angiography for rapid detection of vascular abnormalities in patients with acute cerebrovascular disease
    B Siewert
    Department of Radiology, Beth Isreal Hospital, Boston Mass, USA
    Stroke 28:1211-5. 1997
    ..The potential advantage of the technique is that angiographic images can be acquired in less than 1 minute...
  99. ncbi Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution
    A Kimmelman
    The Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Oncogene 15:2675-85. 1997
    ....
  100. ncbi Relationship between neurological asymptomatic vertigo and the vertebrobasilar system as revealed by magnetic resonance angiography
    T Seo
    Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya, Japan
    ORL J Otorhinolaryngol Relat Spec 62:63-7. 2000
    ..b>MRAs of the VB system were examined in 31 patients with positional nystagmus of unknown origin (PNU) and in 14 patients ..
  101. ncbi Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3
    Y Ohba
    Department of Pathology, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 182 8655, Japan
    J Biol Chem 275:20020-6. 2000
    ..In conclusion, TC21 and R-Ras were regulated by the same GEFs and GAPs, whereas M-Ras was regulated as the classical Ras...

Research Grants14

  1. Research for Adverse Drug-Events and Reports
    DENNIS PAUL WEST; Fiscal Year: 2010
    ..chronic kidney disease (CKD) or acute kidney injury (AKI) who receive GCCAs during Magnetic Resonance Angiograms (MRAs) and Magnetic Resonance Imaging (MRI) procedures...
  2. Sudha Seshadri; Fiscal Year: 2016
    ..We will systematically assess neurological, imaging (MRI &MRAs), functional, cognitive and mood outcomes in these subjects and provide estimates of lifetime risk, secular trends ..
  3. Preeti Tandon; Fiscal Year: 2014
    ..The overall goal of this research is to delineate the functions of Ras proteins in NF1 pathogenesis and to identify novel therapeutic strategies based on inhibition of specific Ras proteins. ..
  4. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    HAL CHARLES; Fiscal Year: 1999
    ..The MRAS and MR1 data will be correlated with clinical and histologic response to therapy...
  5. R-RAS3 AND CELL SURVIVAL IN THE CENTRAL NERVOUS SYSTEM
    Andrew Chan; Fiscal Year: 2007
    ..Using PC12 and H19-7 neuronal cell lines, the kinetics of activation of RRas3, H-Ras, and Rap1A upon stimulation with EGF, bFGF, and NGF will be compared...
  6. Nanotube Reagentless Proteomic Arrays
    Michael Wilson; Fiscal Year: 2007
    ..In operation, an array would be spotted first in each well with MRAs to the proteins of interest, and then exposed to the analyte solution containing one or more of these protein ..
  7. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2001
    ..We propose a number of studies to evaluate the accuracy and utility of our approach, and we also propose new visualization methods to indicate the uncertainty of our symbolic descriptions of image objects. ..
  8. 3D Image Guided Endovascular Surgery
    Elizabeth Bullitt; Fiscal Year: 2006
    ..Indeed, the methods to be developed under this proposal have the potential to change how endovascular procedures are performed throughout the body. ..
  9. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. Noninvasive assessment of tumor malignancy
    Elizabeth Bullitt; Fiscal Year: 2010
    ....
  11. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..Finally, we will use bioinformatics, statistical methods, and gene sequencing, to identify specific disease producing mutations and/or high risk haplotypes whose functional relevance will be subsequently explored. ..
  12. Interventional Management of Stroke III Planning Grant
    Joseph Broderick; Fiscal Year: 2004
    ..10. Explore funding of interventional angiography by CMS. 11. Continue interaction with industry, with attention to devices that might be applied to a device-augmented future IV/IA paradigm. ..
  13. Rheb GTPase as chemotherapeutic target for brain tumors
    LAWRENCE QUILLIAM; Fiscal Year: 2009
    ..They will address the molecular basis of non-Ras action of FTIs and demonstrate the value of targeting Rheb in cancer therapy. ..