MPHOSPH9

Summary

Gene Symbol: MPHOSPH9
Description: M-phase phosphoprotein 9
Alias: MPP-9, MPP9, M-phase phosphoprotein 9
Species: human

Top Publications

  1. ncbi Genes associated with multiple sclerosis: 15 and counting
    Mario Habek
    School of Medicine, University of Zagreb, Croatia
    Expert Rev Mol Diagn 10:857-61. 2010
  2. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
  3. pmc Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells
    Ryo Saga
    Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036 8564, Japan
    Oncol Lett 13:410-416. 2017
  4. pmc A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head
    Jieli Du
    Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China
    Oncotarget 7:68434-68441. 2016
  5. pmc Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies
    Ren Matsuba
    Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
    PLoS ONE 11:e0154093. 2016
  6. pmc Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels
    Fabrice Danjou
    Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche CNR, Monserrato, Cagliari, Italy
    Nat Genet 47:1264-71. 2015
  7. doi Iodine Affects Differentiation and Migration Process in Trophoblastic Cells
    Zendy Evelyn Olivo-Vidal
    Centro de Investigaciones Biomedicas, Universidad Veracruzana, Av Luis Castelazo Ayala s n, Col Industrial Animas, Xalapa, Veracruz, Mexico
    Biol Trace Elem Res 169:180-8. 2016
  8. pmc The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes
    Marie Neergaard Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 10:e0120890. 2015
  9. doi Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP‑9 via the ERK signaling pathway
    Guang Lin Yang
    Department of General Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P R China
    Oncol Rep 33:2045-51. 2015
  10. ncbi Expression of high mobility group box - B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC)
    Jing luan Wang
    Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, China E mail
    Asian Pac J Cancer Prev 15:4865-9. 2014

Scientific Experts

  • Philip L De Jager
  • Dawei Wu
  • Maija Wolf
  • Benjamin A Goldstein
  • D Reihmane
  • Ryo Saga
  • Jieli Du
  • Ren Matsuba
  • Zendy Evelyn Olivo-Vidal
  • Marie Neergaard Harder
  • Fabrice Danjou
  • Guang Lin Yang
  • Jing luan Wang
  • Ellen M Mowry
  • Won Jing Wang
  • Niamh O'Reilly
  • Apostolia Fragkouli
  • Hanako Fujita
  • Mario Habek
  • O M Kandil
  • Keiko Imamura
  • Gregg R Ward
  • Toshiya Nakamura
  • Satoru Monzen
  • Yoichiro Hosokawa
  • Hironori Yoshino
  • Mitsuru Chiba
  • Junyu Chen
  • Hiroshi Hirose
  • Kazuyuki Tobe
  • Minako Imamura
  • Minoru Iwata
  • Hirotaka Watada
  • Wanlin Liu
  • Kohei Kaku
  • Rui Bai
  • Tianbo Jin
  • Yasushi Tanaka
  • JianZhong Wang
  • Zhenqun Zhao
  • Hiroshi Maegawa
  • Atsunori Kashiwagi
  • Ryuzo Kawamori
  • Shiro Maeda
  • Guoqiang Wang
  • Omar Arroyo-Helguera
  • Mingqi Sun
  • Huiqin Xue
  • Rocío Coutiño Rodríguez
  • Xiyang Zhang
  • Fabio Busonero
  • Hai Rong Tao
  • Jiang Min Zhao
  • Renzo Galanello
  • Wei He
  • Maristella Pitzalis
  • Francesco Cucca
  • Emil Vincent Rosenbaum Appel
  • Han Wei Wang
  • Giorgio Pistis
  • Andrea Angius
  • Cramer Christensen
  • Thorkild I A Sørensen
  • Serena Sanna
  • Magdalena Zoledziewska
  • Chao Zhang
  • Carlo Sidore
  • Eleonora Porcu
  • Li Di Zhang
  • Anette Prior Gjesing
  • Stephan Menzel
  • Timothy D Spector
  • Susanna Barella
  • Yun Sun
  • Lidia Leoni
  • Manuela Uda
  • Feng Hou Gao
  • Maristella Steri
  • Mang Hua Xu
  • Torben Hansen
  • Lucia Perseu
  • Tarunveer S Ahluwalia
  • Allan Linneberg
  • Andrea Maschio
  • Torben Jørgensen
  • Ivan Brandslund
  • Goncalo R Abecasis
  • Swee Lay Thein
  • Niels Grarup
  • Sarah Metrustry

Detail Information

Publications23

  1. ncbi Genes associated with multiple sclerosis: 15 and counting
    Mario Habek
    School of Medicine, University of Zagreb, Croatia
    Expert Rev Mol Diagn 10:857-61. 2010
    Evaluation of: The International Multiple Sclerosis Genetics Consortium (IMSGC). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun. 11(5), 397-405 (2010)...
  2. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  3. pmc Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells
    Ryo Saga
    Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036 8564, Japan
    Oncol Lett 13:410-416. 2017
    ..Taken together, these results suggest that the administration of MU with 2 Gy IR is effective at reducing HA production, cell invasion and the metastatic potential of cancer cells...
  4. pmc A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head
    Jieli Du
    Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China
    Oncotarget 7:68434-68441. 2016
    ..Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these ..
  5. pmc Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies
    Ren Matsuba
    Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
    PLoS ONE 11:e0154093. 2016
    ..to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genome-wide association studies (GWAS) in 2014.
  6. pmc Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels
    Fabrice Danjou
    Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche CNR, Monserrato, Cagliari, Italy
    Nat Genet 47:1264-71. 2015
    ..Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3...
  7. doi Iodine Affects Differentiation and Migration Process in Trophoblastic Cells
    Zendy Evelyn Olivo-Vidal
    Centro de Investigaciones Biomedicas, Universidad Veracruzana, Av Luis Castelazo Ayala s n, Col Industrial Animas, Xalapa, Veracruz, Mexico
    Biol Trace Elem Res 169:180-8. 2016
    ..High iodine doses (1000-5000 μM) have shown cytotoxic effects. Based on our results, iodine is important for keeping the proliferation/differentiation balance in the placenta...
  8. pmc The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes
    Marie Neergaard Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 10:e0120890. 2015
    ..seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9. The aim of our study was to investigate associations between these novel risk variants and type 2 diabetes and ..
  9. doi Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP‑9 via the ERK signaling pathway
    Guang Lin Yang
    Department of General Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P R China
    Oncol Rep 33:2045-51. 2015
    ..The results are therefore useful in the prevention of Ara-C collateral damage associated with standard, conventional protocols of chemotherapy administration. ..
  10. ncbi Expression of high mobility group box - B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC)
    Jing luan Wang
    Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, China E mail
    Asian Pac J Cancer Prev 15:4865-9. 2014
    ..This study evaluated the expression level of high mobility group box-B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC) inmorder to reveal any relation with development and prognosis...
  11. pmc Multiple sclerosis susceptibility genes: associations with relapse severity and recovery
    Ellen M Mowry
    Multiple Sclerosis Center, Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 8:e75416. 2013
    ..Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes are associated with these attack features or with the risk of a second attack...
  12. pmc CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base
    Won Jing Wang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Cell Biol 15:591-601. 2013
    ..CEP162 is thus an axoneme-recognition protein pre-tethered at centriole distal ends before ciliogenesis to promote and restrict transition zone formation specifically at the cilia base...
  13. doi Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea
    Niamh O'Reilly
    Department of Biology, NUI Maynooth, Co Kildare, Ireland
    Invest Ophthalmol Vis Sci 53:3250-9. 2012
    ..The aim of the work presented here was to establish the response of a corneal epithelial cell line (hTCEpi) to protein extracted from a bacterium (Bacillus oleronius) previously isolated from a Demodex mite from a rosacea patient...
  14. doi The relationship between maximal exercise-induced increases in serum IL-6, MPO and MMP-9 concentrations
    D Reihmane
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 76:188-92. 2012
    ..Furthermore, correlation between increases in serum IL-6 and MMP-9 concentrations may suggest that IL-6 could exert modulatory effects on MMP-9 release during maximal exercise...
  15. doi Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9
    Apostolia Fragkouli
    Laboratory of Cell and Matrix Pathobiology, Institute of Biology, NCSR Demokritos, Athens, Greece
    J Neurochem 121:239-51. 2012
    ..Moreover, elevated sAPPα levels in the hippocampus and cortex of MPP9 transgenic animals were also observed...
  16. pmc Identification of novel M phase phosphoproteins by expression cloning
    N Matsumoto-Taniura
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 7:1455-69. 1996
    ..Three MPPS were strikingly localized to interphase structures: MPP7 to centers of DNA replication, MPP9 to the Golgi complex, and MPP10 to nucleoli. In mitosis, most of the MPPs were distributed throughout the cells...
  17. doi Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:420-30. 2011
    ..Doxycycline hydrochloride (DOXY), an inhibitor of MMPs, attenuates pulmonary fibrosis in models and in patients with IPF; however, the mechanism of this action remains obscure...
  18. pmc An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings
    Benjamin A Goldstein
    Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
    BMC Genet 11:49. 2010
    ..One such approach is the Random Forests (RF) algorithm. The use of RF for SNP discovery related to human disease has grown in recent years; however, most work has focused on small datasets or simulation studies which are limited...
  19. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
    ..Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma...
  20. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
    ..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
  21. doi Transcriptional analysis of buffalo (Bubalus bubalis) oocytes during in vitro maturation using bovine cDNA microarray
    O M Kandil
    Department of Animal Reproduction and A I, National Research Centre, Dokki, Giza, Egypt
    Reprod Domest Anim 45:63-74. 2010
    ..Among these, transcription factors (ZFP91), M-phase mitotic cell cycle (MPHOSPH9), growth factor (BMP15) and DNA binding (HMGN2) were found to be up-regulated in immature oocytes...
  22. ncbi Increased plasma matrix metalloproteinase-9 levels in migraineurs
    Keiko Imamura
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    Headache 48:135-9. 2008
    ..To seek their possible association, we investigated plasma MMP-9 levels in migraineurs during headache-free periods...
  23. ncbi Glucocorticoids plus opioids up-regulate genes that influence neuronal function
    Gregg R Ward
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Cell Mol Neurobiol 27:651-60. 2007
    ..FRS2 (fibroblast growth factor receptor substrate-2; CTNNB1 (beta1-catenin); PRCP (prolyl-carboxypeptidase); MPHOSPH9 (M-phase phosphoprotein 9); and ZFP95 (zinc finger protein 95) serve important neuronal functions in signal ..