MPG

Summary

Gene Symbol: MPG
Description: N-methylpurine DNA glycosylase
Alias: AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg, DNA-3-methyladenine glycosylase, 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, CRA36.1 (3-methyl-adenine DNA glycosylase), N-methylpurine-DNA glycosylase, MPG, proliferation-inducing protein 11, proliferation-inducing protein 16
Species: human

Top Publications

  1. pmc Rapid identification of Candida dubliniensis with commercial yeast identification systems
    D H Pincus
    bioMerieux, Inc, Hazelwood, Missouri 63042 2320, USA
    J Clin Microbiol 37:3533-9. 1999
  2. pmc Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases
    M Saparbaev
    URA 147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    Proc Natl Acad Sci U S A 91:5873-7. 1994
  3. ncbi Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision
    A Y Lau
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 95:249-58. 1998
  4. ncbi Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase
    Aarthy C Vallur
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610 0245, USA
    J Biol Chem 277:31673-8. 2002
  5. ncbi 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins
    F Miao
    Department of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 275:28433-8. 2000
  6. pmc Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG
    A Y Lau
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:13573-8. 2000
  7. ncbi Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors
    Nam Keun Kim
    Department of Biochemistry, Institute for Clinical Research, College of Medicine, Pochon CHA University, Sungnam 463 712, S Korea
    Anticancer Res 23:1417-23. 2003
  8. ncbi Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines
    PATRICK J O'BRIEN
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 42:12418-29. 2003
  9. ncbi Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase
    PATRICK J O'BRIEN
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:9750-7. 2004
  10. ncbi Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct
    Laurent Gros
    Groupe Réparation de l ADN, CNRS Unité Mixte de Recherche 8113 LBPA ENS Cachan, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Biol Chem 279:17723-30. 2004

Research Grants

  1. The contribution of anatomic pathology to the health of women and children
    Drucilla J Roberts; Fiscal Year: 2011
  2. Edward N Okeke; Fiscal Year: 2014
  3. David Ross; Fiscal Year: 2016
  4. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
  5. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
  6. Experimental Therapeutics in Acute Leukemias
    William G Blum; Fiscal Year: 2010
  7. Metal inhibition of the base excision repair enzymes
    Anton Guliaev; Fiscal Year: 2013
  8. CATHERINE KOTO; Fiscal Year: 2014
  9. Pranoti Mandrekar; Fiscal Year: 2016
  10. Inflammation and Oxidative Stress in Hyperglycemic Exacerbation of Infarct Size
    Irving L Kron; Fiscal Year: 2013

Detail Information

Publications314 found, 100 shown here

  1. pmc Rapid identification of Candida dubliniensis with commercial yeast identification systems
    D H Pincus
    bioMerieux, Inc, Hazelwood, Missouri 63042 2320, USA
    J Clin Microbiol 37:3533-9. 1999
    ..In addition, assimilation of methyl-alpha-D-glucoside (MDG), D-trehalose (TRE), and D-xylose (XYL) by the same isolates was investigated by the traditional procedure of ..
  2. pmc Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases
    M Saparbaev
    URA 147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    Proc Natl Acad Sci U S A 91:5873-7. 1994
    ..Duplex oligodeoxynucleotides containing hypoxanthine positioned opposite T, G, C, and A were cleaved efficiently. ANPG protein, APDG protein, and MAG protein--the 3-methyladenine DNA glycosylases of human, rat, and yeast origin, ..
  3. ncbi Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision
    A Y Lau
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 95:249-58. 1998
    ..The structure shows an elegant means of exposing a nucleotide for base excision as well as a network of residues that could catalyze the in-line displacement of a damaged base from the phosphodeoxyribose backbone...
  4. ncbi Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase
    Aarthy C Vallur
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610 0245, USA
    J Biol Chem 277:31673-8. 2002
    ..These results are consistent with a role for Tyr-162 in pushing the damaged base to assist in nucleotide flipping and indicate that a nucleotide flipping step may be rate-limiting for excision of hypoxanthine...
  5. ncbi 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins
    F Miao
    Department of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 275:28433-8. 2000
    Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases...
  6. pmc Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG
    A Y Lau
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:13573-8. 2000
    The human 3-methyladenine DNA glycosylase [alkyladenine DNA glycosylase (AAG)] catalyzes the first step of base excision repair by cleaving damaged bases from DNA...
  7. ncbi Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors
    Nam Keun Kim
    Department of Biochemistry, Institute for Clinical Research, College of Medicine, Pochon CHA University, Sungnam 463 712, S Korea
    Anticancer Res 23:1417-23. 2003
    ..Several studies have shown that N-methylpurine-DNA-glycosylase (MPG) mRNA levels were lower in adult brain than in other tissues...
  8. ncbi Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines
    PATRICK J O'BRIEN
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 42:12418-29. 2003
    Human alkyladenine DNA glycosylase (AAG) protects against alkylative and oxidative DNA damage, flipping damaged nucleotides out of double-stranded DNA and catalyzing the hydrolytic cleavage of the N-glycosidic bond to release the damaged ..
  9. ncbi Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase
    PATRICK J O'BRIEN
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:9750-7. 2004
    Human alkyladenine-DNA glycosylase (AAG) catalyzes the excision of a broad range of modified bases, protecting the genome from many types of alkylative and oxidative DNA damage...
  10. ncbi Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct
    Laurent Gros
    Groupe Réparation de l ADN, CNRS Unité Mixte de Recherche 8113 LBPA ENS Cachan, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Biol Chem 279:17723-30. 2004
    ..Here, we report the efficient biological hijacking of the human alkyl-N-purine-DNA glycosylase (ANPG) by 3,N(4)-ethenocytosine (epsilonC) when present in DNA...
  11. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, LIG3 and EXO1; double-strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1 and ..
  12. pmc Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition
    Peter Broderick
    Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    BMC Cancer 6:243. 2006
    ..It is conceivable that germline sequence variation in other BER pathway genes such as NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 also contribute to CRC susceptibility.
  13. pmc Human alkyladenine DNA glycosylase employs a processive search for DNA damage
    Mark Hedglin
    Chemical Biology Program, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    Biochemistry 47:11434-45. 2008
    ..Human alkyladenine DNA glycosylase (AAG) is responsible for recognizing a variety of base lesions, including alkylated and deaminated purines, and ..
  14. pmc Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG)
    Chun Yue I Lee
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 48:1850-61. 2009
    The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadenine (epsilonA)..
  15. pmc Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase
    Larry E Jones
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Carcinogenesis 30:2123-9. 2009
    ..repaired predominantly by the base excision repair (BER) pathway, which includes the alkyladenine DNA glycosylase (AAG). The AAG active site contains several tyrosines and cysteines that are potential sites for modification by RNS...
  16. pmc Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase
    Joanna Klapacz
    Department of Biological Engineering, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 37:843-53. 2010
    ..This study provides important insights into the mechanism of hAAG-induced genomic instability...
  17. doi Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis
    S Y Chen
    Genetic Center, Department of Medical Research, Taichung, Taiwan
    J Appl Genet 51:519-21. 2010
    ..In this study, we investigated the association of four N-methylpurine-DNA glycosylase (MPG) gene polymorphisms (rs3176364, rs710079, rs2858056, and rs2541632) with susceptibility to RA in 384 Taiwanese ..
  18. pmc Substitution of active site tyrosines with tryptophan alters the free energy for nucleotide flipping by human alkyladenine DNA glycosylase
    Jenna M Hendershot
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 5606, United States
    Biochemistry 50:1864-74. 2011
    Human alkyladenine DNA glycosylase (AAG) locates and excises a wide variety of structurally diverse alkylated and oxidized purine lesions from DNA to initiate the base excision repair pathway...
  19. pmc Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA
    Gondichatnahalli M Lingaraju
    Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:13205-13. 2011
    ..Although the human alkyladenine DNA glycosylase (AAG) can specifically bind DNA containing either 1,N(6)-ethenoadenine (εA) lesions or 3,N(4)-ethenocytosine (εC) ..
  20. pmc Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase
    Jeremy W Setser
    Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biochemistry 51:382-90. 2012
    To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions...
  21. ncbi Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in human gonads
    Nam Keun Kim
    Department of Biochemistry and Institute for Clinical Research, College of Medicine, Pochon CHA University, Sungnam, Korea
    Anticancer Res 22:793-8. 2002
    The multifunctional mammalian MPG is responsible for a damaged DNA base in the nucleus. The DNA repair enzyme is transported from the cytoplasm to nucleus to repair the DNA base when it is damaged...
  22. ncbi Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase
    Thomas M Hitchcock
    Department of Genetics, Biochemistry and Life Science Studies, South Carolina Experiment Station, Clemson University, Clemson, South Carolina 29634, USA
    J Biol Chem 279:38177-83. 2004
    ..Among the known human DNA glycosylases tested, human alkyladenine glycosylase (AAG) shows ODG activity, whereas hOGG1, hNEIL1, or hNEIL2 did not...
  23. pmc Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein
    Mark Hedglin
    Chemical Biology Program, University of Michigan, Ann Arbor, Michigan 48109 5606, USA
    ACS Chem Biol 5:427-36. 2010
    ..to detect the ability of a DNA modifying enzyme to hop and have applied it to human alkyladenine DNA glycosylase (AAG), a monomeric enzyme that initiates repair of alkylated and deaminated purine bases...
  24. pmc Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16
    L Samson
    Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115
    Proc Natl Acad Sci U S A 88:9127-31. 1991
    ....
  25. ncbi Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals?
    W Westlin
    Department of Pharmacology, New York Medical College, Valhalla
    Circulation 77:I30-9. 1988
    ..and teprotide, which lack the sulfhydryl group but inhibit ACE, and two compounds, N-2-mercaptopropionylglycine (MPG) and N-acetylcysteine (NAC), which contain a thiol moiety but are not ACE inhibitors, for suppression of free ..
  26. doi DNA damage after phototherapy in wounded fibroblast cells irradiated with 16 J/cm(2)
    Alwin B Mbene
    Laser Research Group, Faculty of Health Sciences, University of Johannesburg, P O Box 17011, Doornfontein, Johannesburg 2028, South Africa
    J Photochem Photobiol B 94:131-7. 2009
    ..It has been shown to induce DNA damage; however this damage appears to be repairable. This study aimed to determine the effects of phototherapy induced DNA damage and activation of the DNA repair gene methylpurine DNA glycosylase (MPG).
  27. ncbi Keratin 9 mutations in the coil 1A region in epidermolytic palmoplantar keratoderma
    S Szalai
    Department of Dermatology, , Budapest, Hungary
    Pediatr Dermatol 16:430-5. 1999
    ..In the other, we observed a novel mutation at nucleotide position 571, which changes codon 169 lysine (AAG) into the amber stop codon (TAG) (K169X)...
  28. pmc Drivers of inequality in Millennium Development Goal progress: a statistical analysis
    David Stuckler
    Oxford University, Department of Sociology, Oxford, UK
    PLoS Med 7:e1000241. 2010
    ..We also examined the impact of joint epidemics of HIV/AIDS and noncommunicable diseases (NCDs), which may limit the ability of households to address child mortality and increase risks of infectious diseases...
  29. ncbi High-performance liquid chromatographic determination of total plasma homocysteine with or without internal standards
    R Accinni
    C.N.R. Institute of Clinical Physiology, Medical and Surgical Cardio-Thoracic Department, Niguarda Hospital, Milan, Italy
    J Chromatogr A 828:397-400. 1998
    ..S.) of alpha-mercaptopropionylglycine (MPG), 2-mercaptoethylamine (ME), or N-acetylcysteine (NAC) or without I.S., and to verify whether the use of an I.S...
  30. ncbi Lead induced spermatoxicity in mouse and MPG treatment
    A K Gautam
    Division of Reproductive Toxicology, National Institute of Occupationa Health, Meghani Nagar, Ahmedabad, India
    J Environ Biol 22:287-91. 2001
    Protective efficacy of MPG (2-mercaptopropionyl glycine) was studied against the toxic effects of lead acetate in Swiss albino mice. The animals were treated with single dose of lead acetate @ 180, 200 and 250 mg/kg b.wt...
  31. ncbi Improving child survival through environmental and nutritional interventions: the importance of targeting interventions toward the poor
    Emmanuela Gakidou
    Initiative for Global Health, Harvard University, Cambridge, Massachusetts, USA
    JAMA 298:1876-87. 2007
    ..A critical but underinvestigated question for planning and allocating resources toward the MDGs is how interventions related to one MDG might affect progress toward other goals.
  32. pmc Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents
    Jason F Harrison
    Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688, USA
    Glia 55:1416-25. 2007
    ..expression system was employed to target high levels of the BER pathway initiator, N-methylpurine glycosylase (MPG), to either the mitochondria or nucleus of primary astrocytes to test the hypothesis that an alteration in BER ..
  33. ncbi Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561
    Azad Kumar
    Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Biochemistry 46:2758-66. 2007
    ..studies with hSGLT1, significant sodium-independent phlorizin inhibitable alpha-methyl d-glucopyranoside (alpha-MDG) uptake was observed which amounted to approximately 20% of the uptake observed in the presence of a sodium ..
  34. pmc Child health and mortality
    Shams El Arifeen
    ICDDR, B, Mohakhali, Dhaka 1212, Bangladesh
    J Health Popul Nutr 26:273-9. 2008
    ..one of the very few countries in the world, which is on target for achieving the Millennium Development Goal (MDG) 4 relating to child mortality...
  35. doi N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage
    Zoulikha M Zaïr
    Institute of Life Science, Swansea University, Swansea, SA2 8PP, UK
    Toxicol Sci 119:346-58. 2011
    ..N-methylpurine DNA glycosylase (MPG), an initiator glycosylase of the base excision repair (BER) pathway, typically repairs alkyl-induced DNA adducts, ..
  36. pmc Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase
    Michael R Baldwin
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    Biochemistry 48:6022-33. 2009
    Human alkyladenine DNA glycosylase (AAG) locates and excises a wide variety of damaged purine bases from DNA, including hypoxanthine that is formed by the oxidative deamination of adenine...
  37. ncbi Slow base excision by human alkyladenine DNA glycosylase limits the rate of formation of AP sites and AP endonuclease 1 does not stimulate base excision
    Robyn L Maher
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610 0245, United States
    DNA Repair (Amst) 6:71-81. 2007
    ..Human alkyladenine DNA glycosylase (AAG) is one of several damage-specific DNA glycosylases that recognizes and excises damaged DNA bases...
  38. ncbi N-terminal extension of N-methylpurine DNA glycosylase is required for turnover in hypoxanthine excision reaction
    Sanjay Adhikari
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 282:30078-84. 2007
    N-Methylpurine DNA glycosylase (MPG) initiates base excision repair in DNA by removing a wide variety of alkylated, deaminated, and lipid peroxidation-induced purine adducts...
  39. ncbi The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice
    Richard F Branda
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Mutat Res 615:12-7. 2007
    ..Weanling wild-type or 3-methyladenine glycosylase (Aag) null mice were maintained on a FA- diet or the same diet supplemented with folic acid (FA+) for 4 weeks...
  40. pmc Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells
    Nathalie Gaspar
    Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Cancer Res 69:1966-75. 2009
    Heat shock protein 90 (HSP90) inhibitors, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin), which is currently in phase II/phase III clinical trials, are promising new anticancer agents...
  41. pmc N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide
    Jiang bo Tang
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuro Oncol 13:471-86. 2011
    ..N-methylpurine DNA glycosylase (MPG) initiates BER by removing TMZ-induced N3-methyladenine and N7-methylguanine base lesions, leaving abasic sites (AP ..
  42. ncbi Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols
    V Mollace
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London, United Kingdom
    J Pharmacol Exp Ther 258:820-3. 1991
    ..enalaprilat (ENA) and other structurally unrelated sulfhydryl-containing compounds, N-2-mercaptopropionylglycine (MPG) or N-acetyl-L-cysteine (NAC), could influence platelet aggregation...
  43. ncbi Radioprotection by MPG of mice ovaries exposed to sublethal gamma radiation doses at different postnatal ages
    S Mathur
    Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Acta Oncol 30:981-3. 1991
    ..6, 1.2 and 2.4 Gy) of gamma radiation in the presence or absence of 2-mercaptopropionylglycine (MPG). Ovaries were histologically examined at different intervals after irradiation and the follicles were counted...
  44. ncbi The genetic variant A of human alpha 1-acid glycoprotein limits the blood to brain transfer of drugs it binds
    P Jolliet-Riant
    Service de Pharmacologie, Faculté de Médecine de Créteil Paris XII, Creteil, France
    Life Sci 62:PL219-26. 1998
    The objective of this work was to check the effects of alpha-1 acid glycoprotein (AAG) and of its components, A and F1/S genetic variants, on the brain transfer of drugs they bind in plasma...
  45. ncbi Achieving the goal of halving global hunger by 2015
    Prakash Shetty
    Food and Nutrition Division, Food and Agriculture Organization of the UN, Viale delle Terme di Caracalla, Rome, Italy
    Proc Nutr Soc 65:7-18. 2006
    ..suffering hunger by the year 2015, which was later incorporated into the UN Millennium Development Goals (MDG) that commit the international community to an expanded vision of development, and one that vigorously promotes ..
  46. ncbi Pharmacokinetics of bupivacaine during postoperative epidural infusion: enantioselectivity and role of protein binding
    Bernadette Th Veering
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:1062-9. 2002
    ..study examined the effect of postoperative increases (in response to surgery) in plasma alpha1-acid-glycoprotein (AAG) concentrations on the plasma concentrations of the enantiomers of bupivacaine during continuous epidural infusion ..
  47. pmc Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
    B P Engelward
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    EMBO J 15:945-52. 1996
    ..We previously isolated and characterized a mouse 3MeA DNA glycosylase cDNA (Aag) that provides resistance to killing by alkylating agents in E. coli...
  48. ncbi Purification and biochemical characterization of recombinant N-methylpurine-DNA glycosylase of the mouse
    R Roy
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston 77555
    Biochemistry 33:15131-40. 1994
    The mouse N-methylpurine-DNA glycosylase (MPG), responsible for the removal of most N-alkyladducts in DNA, was purified to homogeneity as a recombinant nonfusion protein from Escherichia coli...
  49. ncbi Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11
    B P Engelward
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115
    Carcinogenesis 14:175-81. 1993
    ..We described previously the isolation of a human 3MeA DNA glycosylase (AAG) cDNA that maps to chromosome 16 and hybridizes to specific genomic DNA fragments from a number of mammals, ..
  50. ncbi Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG)
    R Roy
    Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas, Medical Branch, Galveston, Texas 77555 1079, USA
    J Biol Chem 275:4278-82. 2000
    N-Methylpurine-DNA glycosylase (MPG) initiates base excision repair in DNA by removing a variety of alkylated purine adducts...
  51. ncbi Spatial expression of a DNA repair gene, N-methylpurine-DNA glycosylase (MPG) during development in mice
    N K Kim
    Department of Biochemistry, College of Medicine, Pochon CHA University, Korea
    Anticancer Res 20:3037-43. 2000
    ..If the damaged DNA is not repaired, it may lead to mutation, chromosomal aberration, aging and cancer. N-methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, removes N-methylpurine and other damaged purines in DNA.
  52. ncbi Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes
    N Empadinhas
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Rua da Quinta Grande 6, Apartado 127, 2780 156 Oeiras, Portugal
    J Biol Chem 276:43580-8. 2001
    ..Pyrococcus horikoshii is proposed based on the activities of purified recombinant mannosyl-3-phosphoglycerate (MPG) synthase and mannosyl-3-phosphoglycerate phosphatase...
  53. ncbi A structure-function study of MID1 mutations associated with a mild Opitz phenotype
    Laila Mnayer
    The Dr John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
    Mol Genet Metab 87:198-203. 2006
    ..The MID1 gene was implicated in OS by linkage to Xp22...
  54. ncbi The influence of a multifunctional, polymeric biomaterial on the concentration of acute phase proteins in an animal model
    Dorothee Rickert
    Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Frauenstr 12, 89075 Ulm, Germany
    Clin Hemorheol Microcirc 36:301-11. 2007
    The concentrations of the acute phase proteins alpha1-Acid Glycoprotein (AAG) and haptoglobin were determined in Sprague-Dawley-rats after implantation of a novel biodegradable multifunctional polymeric biomaterial for the reconstruction ..
  55. pmc Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination
    Simonne Longerich
    Committee on Immunology, University of Chicago, Chicago, IL 60637, United States
    DNA Repair (Amst) 6:1764-73. 2007
    ..Adenosine deamination would generate hypoxanthine (Hx), a substrate for the alkyladenine DNA glycosylase (Aag)...
  56. doi Serum acute phase protein concentrations in dogs with autoimmune hemolytic anemia
    K D Mitchell
    Department of Clinical Studies, University of Guelph, Guelph, ON, Canada
    J Vet Intern Med 23:585-91. 2009
    ..Serial monitoring of acute phase protein (APP) concentrations in canine autoimmune hemolytic anemia (AIHA) has not been reported...
  57. doi FK506 and rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury
    Gwen Lagoda
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2411, USA
    J Sex Med 6:1914-23. 2009
    ..Immunophilin ligands function by binding to receptor proteins such as FK506 binding proteins (FKBPs). FKBPs are studied for their roles in neuroprotection...
  58. doi Kinetics of {alpha}2-macroglobulin and {alpha}1-acid glycoprotein in rats subjected to repeated acute inflammatory stimulation
    Toshio Honjo
    Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan
    Lab Anim 44:150-4. 2010
    The kinetics of alpha(2)-macroglobulin (alpha2M) and alpha(1)-acid glycoprotein (AAG) in rats repeatedly stimulated with intramuscular injections of turpentine oil at doses 0.05 and 0.4 mL/rat were investigated...
  59. pmc Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs
    Yuval Samuni
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 48:1559-63. 2010
    ..Because of its adverse effects on liver, its less toxic derivatives 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) are currently being evaluated for the ..
  60. doi Efficacy of a lactylate on production performance and intestinal health of broilers during a subclinical Clostridium perfringens infection
    M Lensing
    Schothorst Feed Research, Meerkoetenweg 26, 8218 NA, Lelystad, Netherlands
    Poult Sci 89:2401-9. 2010
    ..First, the effect of LauL was compared with capric and lauric mono- and diglycerides (MDG) and capric and lauric free fatty acids in Clostridium-infected chickens...
  61. ncbi Acidity and proton affinity of hypoxanthine in the gas phase versus in solution: intrinsic reactivity and biological implications
    Xuejun Sun
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Org Chem 72:6548-55. 2007
    ..Alkyladenine DNA glycosylase (AAG) is the enzyme responsible for excising hypoxanthine from DNA in humans...
  62. ncbi Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinomas of transgenic mice expressing the SV40 large T-antigen gene
    N K Kim
    College of Medicine, Pochon CHA University, Kyonggi Do, Korea
    Mol Cells 8:383-7. 1998
    ..We have analyzed the expression of a DNA repair gene, N-methylpurine-DNA glycosylase (MPG), from different tissues of a non-transgenic (control) and SV40 T-ag expressing transgenic mice at the mRNA level...
  63. ncbi Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs
    G J Finlay
    Auckland Cancer Society Research Centre, University of Auckland School of Medicine, New Zealand
    Cancer Chemother Pharmacol 45:417-22. 2000
    ..These have been shown to reduce the free plasma concentrations of a number of anticancer drugs, particularly of those of complex organic structure, in both experimental studies and clinical trials...
  64. ncbi [Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]
    Dong Wang
    Cancer Center and Department of Pathology, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhonghua Bing Li Xue Za Zhi 35:352-6. 2006
    The overexpression of N-methylpurine DNA glycosylase (MPG) may imbalance the DNA base excision repair (BER) to sensitize tumor cells to current DNA damage chemotherapy...
  65. pmc Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury
    Sergiy M Nadtochiy
    Department of Anesthesiology, PO Box 604, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 42:812-25. 2007
    ..The reagent S-nitroso-2-mercaptopropionyl-glycine (SNO-MPG) was therefore developed to enhance mitochondrial S-nitrosation and elicit cardioprotection...
  66. doi Countdown to 2015 for maternal, newborn, and child survival: the 2008 report on tracking coverage of interventions
    Jennifer Bryce
    Johns Hopkins School of Public Health, USA
    Lancet 371:1247-58. 2008
    ..Child Survival initiative monitors coverage of priority interventions to achieve the Millennium Development Goals (MDG) for reduction of maternal and child mortality...
  67. pmc Invited Article: Autonomic ganglia: target and novel therapeutic tool
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA
    Neurology 70:1926-32. 2008
    ..Ganglionic AChR antibodies are found in patients with autoimmune autonomic ganglionopathy (AAG). Patients with AAG typically present with rapid onset of severe autonomic failure...
  68. doi Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene
    Jahye Kim
    Division of Clinical Pharmacy, Department of Medico Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Pharmacol 78:1075-82. 2009
    ..to alkylating agent-induced genotoxic stress through altering the expression of N-methylpurine DNA glycosylase (MPG), the first enzyme in the base excision repair pathway...
  69. pmc Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase
    Abigail E Wolfe
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 5606, USA
    Biochemistry 48:11357-69. 2009
    ..very stable extrahelical complex is formed in which the epsilonA lesion is strongly quenched by interactions in the AAG active site pocket...
  70. ncbi Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols
    M C Seeds
    Department of Internal Medicine Section on Pulmonary and Critical Care, Bowman Gray School of Medicine, Wake Forest University, Medical Center Blvd, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1394:224-34. 1998
    We have shown previously that both 1,2-diacylglycerol (AAG) and 1-O-alkyl-2-acylglycerol (EAG) prime neutrophil release of arachidonic acid via uncharacterized phospholipases A2...
  71. ncbi Isolation and characterization of a novel immunomodulatory alpha-glucan-protein complex from the mycelium of Tricholoma matsutake in basidiomycetes
    Hirotaka Hoshi
    Biomedical Research Laboratories, Kureha Chemical Industry Co Ltd, Tokyo 169 8503, Japan
    J Agric Food Chem 53:8948-56. 2005
    ..in order to identify the components involved in the expression of the activity, and a single peak fraction (MPG-1) was obtained with reversed phase chromatography. MPG-1 was a glycoprotein (sugar:protein ratio, 94.3:5...
  72. pmc The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex
    Beatriz Aranda-Orgilles
    Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195, Berlin, Germany
    Hum Genet 123:163-76. 2008
    ..The syndrome-causing gene encodes the X-linked E3 ubiquitin ligase MID1 that mediates ubiquitin-specific modification and degradation of the catalytic subunit of the translation regulator ..
  73. ncbi Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance
    Elizabeth R Glaze
    Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Executive Plaza North, Room 8040, Rockville, MD 20852, USA
    Cancer Chemother Pharmacol 56:637-47. 2005
    ..17-DMAG is a hydrophilic derivative of the molecular chaperone inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG; NSC-330507), which is currently being evaluated for the treatment of cancer in clinical trials...
  74. pmc Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning
    Turhan Dost
    Dept of Physiology, MSB 3074, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA
    Basic Res Cardiol 103:378-84. 2008
    ..The third group was also preconditioned, but the free radical scavenger N-2-mercaptopropionyl glycine (MPG 300 microM) was infused during the 10-min reperfusion and therefore was present in the myocardium in the ..
  75. pmc Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observations
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
    Auton Neurosci 146:18-21. 2009
    ..autonomic failure manifest as neurogenic orthostatic hypotension, including autoimmune autonomic ganglionopathy (AAG) and pure autonomic failure (PAF)...
  76. ncbi Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51
    Qing Yao
    The Cancer Center, University of Minnesota MMC 806, 420 Delaware St SE, Minneapolis, Minnesota, USA
    Clin Cancer Res 13:1591-600. 2007
    ..17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), an inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), inhibits growth and induces apoptosis in ..
  77. pmc Reversal of acquired resistance to adriamycin in CHO cells by tamoxifen and 4-hydroxy tamoxifen: role of drug interaction with alpha 1 acid glycoprotein
    M Chatterjee
    Cancer Research Unit, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 62:712-7. 1990
    ..Because alpha 1 acid glycoprotein (AAG) can bind a range of calcium channel blockers that also reverse MDR and rises in malignancy, its interactions with ..
  78. ncbi Clinical pharmacokinetics of mifepristone
    O Heikinheimo
    Department of Biomedicine, University of Helsinki, Finland
    Clin Pharmacokinet 33:7-17. 1997
    ..The serum transport protein alpha 1-acid glycoprotein (AAG) regulates the serum kinetics of mifepristone...
  79. ncbi 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase
    Murat Saparbaev
    Groupe Réparation de l ADN, Unité Mixte de Recherche 8532 CNRS, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquée Ecole Normale Supérieure Cachan, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Biol Chem 277:26987-93. 2002
    ..the Escherichia coli mismatch-specific uracil-DNA glycosylase (MUG) and the human alkylpurine-DNA-N-glycosylase (ANPG), can release 1,N(2)-epsilonG from defined oligonucleotides containing a single modified base...
  80. ncbi The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin
    Nicole Burns
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Toxicol Sci 95:391-400. 2007
    ..deficient in the repair of N3-methyladenine adducts, 3-methyladenine DNA glycosylase (alkyladenine DNA glycosylase [Aag]) null mice, were reported to be resistant to the direct cytotoxic effect of STZ, but later developed autoimmune ..
  81. ncbi Myotube driven myogenic recruitment of cells during in vitro myogenesis
    M Breton
    INSERM U153 and CNRS ERS 64, Paris, France
    Dev Dyn 202:126-36. 1995
    Muscular dysgenesis (mdg) is a recessive lethal mutation in the mouse which drastically affects skeletal muscle development during embryonic life...
  82. pmc DNA repair modulates the vulnerability of the developing brain to alkylating agents
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, United States
    DNA Repair (Amst) 8:400-12. 2009
    ..Parallel studies with neuronal cultures from mice deficient in alkylguanine DNA glycosylase (Aag(-/-)) or O(6)-methylguanine methyltransferase (Mgmt(-/-)), revealed significant differences in the sensitivity of ..
  83. pmc Influence of alpha-1 glycoprotein acid concentrations and variants on atazanavir pharmacokinetics in HIV-infected patients included in the ANRS 107 trial
    A Barrail-Tran
    Hopital Bicetre, Clinical Pharmacy, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:614-9. 2010
    ..of atazanavir and second to evaluate whether plasma protein binding to albumin and alpha-1 glycoprotein acid (AAG) influences the pharmacokinetics of atazanavir in HIV-infected patients...
  84. ncbi Hydrodynamic endurance test of the prosthetic valve used in the various types of the ventricular assist device
    S Nitta
    Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan
    Sci Rep Res Inst Tohoku Univ Med 38:57-62. 1991
    ..The water-hammer phenomenon was evaluated using the maximum pressure gradient (MPG) across the prosthetic valve in the moc circulatory loop...
  85. ncbi The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32
    B Drouet
    Groupe de Biologie, Développement et Régénération du Système Neuromusculaire, INSERM U 153, Paris, France
    Mamm Genome 4:499-503. 1993
    ..On the basis of single-strand conformation polymorphism (SSCP-PCR) analysis in an interspecific backcross, we have determined that the Cchl1a3 = mdg (muscular dysgenesis) locus is very closely linked to the myogenin (Myog) locus.
  86. ncbi Modulation of clinical expression and band 3 deficiency in hereditary spherocytosis
    N Alloisio
    Laboratoire de Génétique Moléculaire Humaine, Centre National de la Recherche Scientifique, URA 1171, Institut Pasteur de Lyon, France
    Blood 90:414-20. 1997
    ..They carried, in trans to allele Coimbra, allele Mondego, defined by two mutations: E40K, GAG --> AAG, the known mutation Montefiore, and P147S, CCT --> TCT, a novel mutation, both located in the cytoplasmic domain ..
  87. ncbi Isolation and characterization of simple sequence repeat loci in the gray tree frog, Hyla chrysoscelis
    J D Krenz
    Division of Biological Sciences, University of Missouri, Columbia 65211 7400, USA
    Genome 42:676-80. 1999
    ..an average-sized insert of 350 bp, was screened with six SSR repeat oligonucleotides (AC, AG, ACG, AGC, AAC, and AAG). Screening identified 31 unique positive clones containing 41 SSR loci...
  88. ncbi Evolutionary rate of a gene affected by chromosomal position
    J Perry
    Section of Gene Function and Regulation Chester Beatty Laboratories Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Curr Biol 9:987-9. 1999
    ..The gene Fxy (also known as MID1 [7]) spans the pseudoautosomal boundary (PAB) in the laboratory mouse (Mus musculus domesticus, C57BL/6) such that ..
  89. ncbi Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix
    E G Pearce
    Department of Dermatology, University of Wales College of Medicine UWCM, Heath Park, Cardiff, UK
    J Invest Dermatol 113:1123-7. 1999
    ..GAG to CAG: E402Q) whereas in patient B, the transition was G to A yielding a lysine substitution (GAG to AAG: E402K)...
  90. ncbi Electromagnetic interference of an implantable loop recorder by commonly encountered electronic devices
    C C de Cock
    Department of Cardiology, University Hospital VU, Amsterdam, The Netherlands
    Pacing Clin Electrophysiol 23:1516-8. 2000
    ..The MDG had no influence on ILR function...
  91. ncbi Human alpha-1-glycoprotein and its interactions with drugs
    Z H Israili
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Rev 33:161-235. 2001
    ..of drugs, especially but not exclusively basic entities, to another plasma protein, alpha 1-acid glycoprotein (AAG), has increasingly become important in this regard...
  92. ncbi Helicobacter pylori vaccine development based on combined subproteome analysis
    Dirk Bumann
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    Proteomics 4:2843-8. 2004
    ..Helicobacter pylori proteomics data are stored in a proteomics database (http://www.mpiib-berlin.mpg.de/2D-PAGE/)...
  93. ncbi Schema-based learning of adaptable and flexible prey-catching in anurans I. The basic architecture
    Fernando Corbacho
    USC Brain Project, University of Southern California, Los Angeles, 90089 0871, USA
    Biol Cybern 93:391-409. 2005
    ..to generate and synchronize motor synergies? What is the role of afferent feedback in shaping the activity of a MPG? How can several MPGs share the same underlying circuitry and yet give rise to different motor patterns under ..
  94. ncbi Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor
    Gang Niu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:99-106. 2008
    The aim of this study is to non-invasively monitor the epidermal growth factor receptor (EGFR) response to a Hsp90 inhibitor-17-AAG treatment in a PC-3 prostate cancer model.
  95. pmc SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers
    Sarat Chandarlapaty
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 14:240-8. 2008
    ..Ansamycins, such as 17-(allylamino)-17-demethoxygeldanmycin (17-AAG), inhibit Hsp90 function; induce the degradation of Hsp90 client proteins such as HER2, and have shown activity in ..
  96. ncbi Structural and functional properties of Viviparous1 genes in dormant wheat
    Shigeko Utsugi
    Research Institute for Bioresources, Okayama University, Kurashiki, Okayama, Japan
    Genes Genet Syst 83:153-66. 2008
    ..Most TaVp-B1 transcripts were spliced correctly, but some had an additional 3-bp (AAG) insertion in the B3 domain, which may not affect their function...
  97. doi Role of reactive oxygen species (ROS) in angiotensin II-induced stimulation of the cardiac Na+/HCO3- cotransport
    Verónica C De Giusti
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900, La Plata, Argentina
    J Mol Cell Cardiol 47:716-22. 2009
    ..70+/-0.15 mM/min, n=8*). This effect of Ang II was abolished when we added to the extracellular solution 2 mM MPG (ROS scavenger; 0.80+/-0.08 mM/min, n=11#), 300 microM apocynin (NADPH oxidase blocker; 0.80+/-0...
  98. ncbi Update on Hsp90 inhibitors in clinical trial
    Y S Kim
    Medical Oncology Branch, NCI, NIH, Bethesda, MD 20892, USA
    Curr Top Med Chem 9:1479-92. 2009
    ..The first-in-class Hsp90 inhibitor 17-AAG entered into Phase I clinical trials in 1999...
  99. doi Dynamical model for assessment of anti-angiogenic therapy of cancer
    Abhik Mukherjee
    Department of Computer Science and Technology, Bengal Engineering and Science University, Shibpur, Botanic Garden, Howrah 711103, West Bengal, India
    Mol Biosyst 6:1047-55. 2010
    Different experimental models have substantially established that the anti-angiogenic (AAG)group of drugs are able to control the growth of tumor mass by cutting down the nutritive supply to the cancer cells...
  100. doi Design and evaluation of micellar nanocarriers for 17-allyamino-17-demethoxygeldanamycin (17-AAG)
    Thripthy Chandran
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
    Int J Pharm 392:170-7. 2010
    17-Allyamino-17-demethoxygeldanamycin (17-AAG) is a potent anticancer agent currently undergoing phases I and II clinical trials...
  101. doi Endoplasmic reticulum is a major target of cadmium toxicity in yeast
    Aurélie Gardarin
    Equipe Transports et Régulations Intracellulaires de Métaux, LCBM iRTSV, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble Cedex 9, France
    Mol Microbiol 76:1034-48. 2010
    ..In particular, Cd(2+) activates the calcium channel Cch1/Mid1, which also contributes to Cd(2+) entry into the cell...

Research Grants76

  1. The contribution of anatomic pathology to the health of women and children
    Drucilla J Roberts; Fiscal Year: 2011
    ..highlight the importance of pathology in helping meet the United Nations'(UN) Millennium Developmental Goals (MDG) to reduce maternal and childhood mortality...
  2. Edward N Okeke; Fiscal Year: 2014
    ..high rates of maternal and child mortality in developing countries are 2 out of the 5 Millennium Development Goals (MDG), yet, many countries continue to lag well behind 2015 MDG targets...
  3. David Ross; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The benzoquinone ansamycin Hsp90 inhibitors 17-AAG and 17-DMAG are in Phase II trials but their use is limited by hepatotoxicity...
  4. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..Among these, a series of structurally diverse damaged purines are repaired by N- methylpurine DNA-glycosylase (MPG), present in all species from bacteria to man...
  5. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..Analogues of geldanamycin (GAAs), e.g., 17-AAG and 17-DMAG, inhibit the ATP binding and chaperone function of hsp90, resulting in misfolding, polyubiquitylation ..
  6. Experimental Therapeutics in Acute Leukemias
    William G Blum; Fiscal Year: 2010
    ..a phase I combination study of the heat shock protein 90 (HspQO) inhibitor 17-allyamino-demethyoxygeldanamycin (17-AAG) with the proteasome inhibitor PS-341 (bortezomib, Velcade) in relapsed and refractory AML...
  7. Metal inhibition of the base excision repair enzymes
    Anton Guliaev; Fiscal Year: 2013
    ..based on our recently obtained data showing that one of the BER enzymes, human N-methylpurine-DNA glycosylase (MPG), is inhibited by several toxic metal ions...
  8. CATHERINE KOTO; Fiscal Year: 2014
    ..X-linked Opitz Syndrome, which is caused by loss of function of Midline-1 (MID1), is a disorder characterized by multiple developmental defects, including hypospadias and CLP...
  9. Pranoti Mandrekar; Fiscal Year: 2016
    ..B) Evaluating the effect of hsp90 inhibitors, 17-AAG and/or 17-DMAG in induction of pro-inflammatory cytokine production, and alleviation of alcoholic liver injury...
  10. Inflammation and Oxidative Stress in Hyperglycemic Exacerbation of Infarct Size
    Irving L Kron; Fiscal Year: 2013
    ..abrogates the hyperglycemic exacerbation of myocardial injury, as does treatment with the potent antioxidant MPG. These studies indicate that acute hyperglycemia in non-diabetics increases the size of MI by interrupting ..
  11. Hsp90s as targets in the development of anticancer drugs
    Neal Rosen; Fiscal Year: 2004
    ..One ansamycin, 17 -allylaminogeeldanamycin (17- AAG) is currently in clinical trial...
  12. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..sites of modification in DNA by enals: acrolein (Acr-dG), t-4-hydroxy-2-nonenal (HNE-dG), and malondialdehyde (MdG)...
  13. BIOLOGIC EFFECTS OF 17AA GELDANAMYCIN
    Howard Scher; Fiscal Year: 2000
    ..will be performed in the context of phase I a clinical trial of 17-N-allylamino-17-demethoxy geldanamycin (17-AAG), the first ansamycin antibiotic to enter clinical testing...
  14. Enzyme Targets, Apoptosis and Purine Metabolism
    VINCENT DAVISSON; Fiscal Year: 2002
    ..on the molecular target(s) for the experimental breast cancer drug l7-allylamino-17- demethoxygeldanamycin (17-AAG)...
  15. Identification of Novel, Drug-like Inhibitors of Hsp90
    Martha Kelly; Fiscal Year: 2007
    ..This hypothesis has been clinically validated by the geldanamycin analogs 17- AAG, and 17-DMAG. However, these ansamycin analogs suffer from poor pharmacokinetic properties and off- target toxicity...
  16. Glen S Kwon; Fiscal Year: 2016
    ..We hypothesize that AmB and 17-allylamino-17-demethoxygeldanamycin (17-AAG), a heat shock protein 90 (Hsp90) inhibitor, will exert potent antifungal activity with low renal toxicity...
  17. Nancy Lundebjerg; Fiscal Year: 2015
    ..activities to advance this work: Developing a multiplatform app for smartphones and tablets that is based on our MPG and developing a portfolio of educational tools that support physicians who want to improve their care of this ..
  18. Leona D Samson; Fiscal Year: 2016
    ..k.a. Mpg/MPG and Apng/APNG), contributes to the response of different cell types upon exposure to DNA damaging agents...
  19. Mechanism, regulation and function of PP2A ubiquitination
    Brian E Wadzinski; Fiscal Year: 2010
    ..The applicant hypothesizes that Mid1/alpha4-dependent mono- and polyubiquitination of PP2Ac determine the enzyme's subcellular localization and ..
  20. Leona D Samson; Fiscal Year: 2014
    ..influences the carcinogenic response by examining mice deficient in one (or more) of numerous DNA repair proteins (Aag, Abh2, Abh3, Myh, Ogg1, and Mbd4)...
  21. Histone Deacetylase Inhibitor Based Therapy of AML
    Kapil Bhalla; Fiscal Year: 2011
    ..the in vitro and in vivo effects of combining HAA-HDIs with hsp90 antagonist 17-allylamino-demethoxy-geldanamycin (AAG) and its more soluble analogue 17-DMAG in attenuating mFLT-3 and the downstream pro-growth and pro-survival ..
  22. Autonomic Control of Urinary Function in Diabetic Mice
    JOHN DANIEL TOMPKINS; Fiscal Year: 2012
    ..The hypothesis will be addressed by investigation of major pelvic ganglion (MPG) structure and function in murine models of diabetes...
  23. PATRICK J O'BRIEN; Fiscal Year: 2016
    ..diffusion contributes to efficient DNA repair in eukaryotic cells;3) Quantify the catalytic specificity of AAG by employing competition kinetics with a wide variety of structurally diverse base lesions;4) Determine the ..
  24. MARGARET ANN VIZZARD; Fiscal Year: 2016
    ..mice;(3) to define the functional properties of bladder postganglionic cells in the major pelvic ganglion (MPG) during development, the underlying channel properties that contribute to the diversity of electrophysiological ..
  25. Functionalized Micellar Nanocarriers for Targeted Cancer Therapy
    Chalet Tan; Fiscal Year: 2010
    ..17-Allylamino-17-demethoxygeldanamycin (17-AAG) is a potent heat shock protein 90 (Hsp90) inhibitor that is currently undergoing Phases I and II clinical trials ..
  26. Structure and Mechanism in DNA Excision Repair
    GREGORY LAWRENCE VERDINE; Fiscal Year: 2013
    ..by glycosylases that repair a variety of genotoxic methylated adducts in DNA (the AlkA protein in bacteria and Aag in humans)...
  27. MICHELE LAURA LENOUE-NEWTON; Fiscal Year: 2014
    ..shown to regulate PP2A stability and expression (14, 15) and localizes to microtubules due to its association with Mid1 (16)...
  28. Hashim M Al-Hashimi; Fiscal Year: 2016
    ....
  29. Comprehensive Analysis of Data from Testing the Re-engineered Hospital Discharge
    VEERAPPA CHETTY; Fiscal Year: 2009
    ..ROCR: Visualizing the performance of scoring classifiers". R package version 1.0-2. http://rocr.bioinf.mpi-sb.mpg.de/ Outcomes: We will publish five papers as listed 1.) risk scores and Intervention effect;2...
  30. Xanthine DNA Glycosylase in Mammalian Systems
    Weiguo Cao; Fiscal Year: 2010
    ..Mammalian alkyladenine DNA glycosylase (Aag) has been identified as xanthine DNA glycosylase (XDG)...
  31. GENETIC SUSCEPTIBILITY TO VINYL CHLORIDE INDUCED CANCER
    Roland Valdes; Fiscal Year: 2000
    ..conjugation of metabolites to glutathione, and, 3) it is decreased through methylpurine-DNA glycosylase (MPG)-initiated removal of etheno-DNA adducts...
  32. HUMAN DNA REPAIR ENZYMES FOR REDOX AND ALKYLATION DAMAGE
    BRUCE F DEMPLE; Fiscal Year: 2010
    ..Determine the contribution of DNA glycosylases (in particular UNG2, OGG1, AAG/MPG, and NTH1) and of oxidative damage as sources of the lethal lesions that accumulate in Ape1-deficient cells; 3...
  33. Histone Deacetylase Inhibitors in CML
    Kapil Bhalla; Fiscal Year: 2009
    ..Accordingly, lowering the levels of Bcr-Abl, e.g., by hsp90 inhibitor 17-AAG or by inhibiting the Bcr-Abl TK activity by imatinib mesylate (IM;Gleevec) inhibits the growth and induces ..
  34. EUKARYOTIC DNA ALKYLATION REPAIR
    Leona D Samson; Fiscal Year: 2010
    ..More recently we found that expression of the human AAG 3-methyadenine DNA glycosylase in yeast and human cells creates a genomic instability phenotype...
  35. Clinical Activity of 17-AAG in Lymphoma
    Anas Younes; Fiscal Year: 2007
    ..17-AAG, a small molecule analog of geldanamycin, binds specifically and inhibits HSP-90 function, causing degradation of ..
  36. FUSION AND NUCLEAR RESCUE DOMAINS IN DYSGENIC MICE
    JEANNE POWELL; Fiscal Year: 1991
    ..Muscular dysgenesis is a murine disorder, which results from a single lethal, recessive, autosomal mutation (mdg), characterized by progressive degeneration of embryonic skeletal muscle and lack of muscle contraction...
  37. DETERMINANTS OF STEROID HORMONES IN BLACK AND WHITE MEN
    Susan Gapstur; Fiscal Year: 2006
    ..As part of the CMHS, concentrations of 3alpha-androstanediol glucuronide (AAG), IGF-1, IGF binding protein-3 (IGFBP-3), and sex hormone binding globulin (SHBG) were measured in serially ..
  38. MODULATION OF DRUGS BY PLASMA PROTEINS
    Svein Oie; Fiscal Year: 1991
    ..will aim to identify the mechanism(s) responsible for the "protein effect" related to alpha-1-acid glycoprotein (AAG), an acute phase reactant, and to determine the importance of other acute phase reactants after induction of acute ..
  39. Gleevec plus novel anti-Bcr-Abl strategies in Leukemias
    Kapil Bhalla; Fiscal Year: 2005
    ..Notably, these cells are sensitive to novel anti-Bcr-Abl targeted agents 17-allyl-amino geldanamycin (17-AAG) or PD 180970...
  40. Damage Recognition by a Human DNA-Repair Glycosylase
    PATRICK O BRIEN; Fiscal Year: 2004
    In humans, a single enzyme, alkyladenine DNA glycosylase (AAG), safeguards the cell against a wide variety of alkylated and deaminated DNA bases...
  41. Male sex behavior and development of the pelvic ganglia
    LYNWOOD CLEMENS; Fiscal Year: 2007
    ..stimulation on the development of the spinal nucleus of the bulbocavernosus (SNB), the major pelvic ganglion (MPG), and male reproductive behavior in the laboratory rat. 2...
  42. Novel Small Molecule Hsp90 Therapeutics to Treat Glioma
    Ruihong Chen; Fiscal Year: 2009
    ..inhibition of cancer cell growth in various tumor models and the first inhibitor in clinical development, 17-AAG, is in Phase II/III development for cancer...
  43. Preclinical Evaluation of a Novel Hsp90 inhibitor in Mutant Tau Mice
    Leonard Petrucelli; Fiscal Year: 2009
    ..90 (HSP90) inhibitors such as geldanamycin (GA) and its derivatives (17-allylamino-17-demethoxygeldanamycin;17-AAG) can pharmacologically modulate chaperone levels and have recently been implicated for the treatment of cancer;..
  44. A phase II study of IPI-504 in metastatic hormone refractory prostate cancer
    William Oh; Fiscal Year: 2009
    ..Based on this hypothesis, trials of 17-allylaminogeldanamycin (17-AAG), an HSP90 inhibitor, in CaP have been initiated...
  45. Novel Geldanamycin Analogs as Anti-tumor Agents
    Gary Ashley; Fiscal Year: 2005
    ..17-Allylamino-17-desmethoxygeldanamycin (17-AAG), the first Hsp90 inhibitor to enter Phase I clinical trials for cancer chemotherapy, has shown higher blood levels ..
  46. A Phase I Study of the AKT Inhibitor 17-AAG in CLL
    Thomas Lin; Fiscal Year: 2006
    ..The investigational drug 17-allylamino-17-demethoxygeldanamycin (17-AAG) depletes AKT by inhibiting the chaperone protein Hsp90, which normally protects AKT from proteosomal degradation...
  47. Phase II trial of 17-AAG in melanoma patients
    Paul Chapman; Fiscal Year: 2007
    ..Inhibition of HSP90 by 17-AAG results in depletion of BRAF in cell lines and in xenograft models and inhibition of cell growth...
  48. Novel Geldanamycin Analogs as Anti-tumor Agents
    Charles Hutchinson; Fiscal Year: 2002
    ..17-Allyamino-17- demethoxygeldanamycin (17-AAG) is in clinical trials...
  49. E-C Coupling: Signaling Between Calcium Channels
    Paul Allen; Fiscal Year: 2006
    ..Data from our dysgenic (mdg) mouse model have defined the critical regions of the slow voltage gated Ca 2+ channel in the surface membrane (..
  50. Relevance of circulating mutant BRAF DNA in melanoma
    David Polsky; Fiscal Year: 2006
    ..institution testing BAY 43-9006, and the other collaborating with Memorial Sloan-Kettering Cancer Center testing 17-AAG) which require that the patients undergo biopsy of their metastatic lesion for sequencing of the BRAF gene to be ..
  51. SRC AS A NOVEL TARGET FOR HUMAN COLON CANCER THERAPY
    Timothy Yeatman; Fiscal Year: 2004
    ..PI has recently received a renewal of his funding through the American Cancer Society as a Research project Grant (MPG 97751; 1/99 - 1/02) entitled "Src Activation in Colon Cancer...
  52. Mechanical Injury to Lung Endothelium
    James Parker; Fiscal Year: 2001
    ..pore distribution in monolayers of the three EC phenotypes will be measured with and without expression of the MID1 gene product to determine the role of SACC in initiating the increased permeability as wet as certain cellular ..
  53. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  55. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  56. Potentiation of Topo Inhibitors by the HDACi, SAHA
    Pamela Munster; Fiscal Year: 2007
    ..These findings may be useful in the rational design of future clinical trials involving HDACi. [unreadable] [unreadable]..
  57. Potentiation of Topo Inhibitors by HDAC Inhibitors
    Pamela Munster; Fiscal Year: 2005
    ..Finally, the utility of the topo II inhibitors could be enhanced if their efficacy could be increased without worsening toxicity, as our preclinical data appears to indicate. ..
  58. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  59. FUNCTIONAL CHARACTERIZATION OF AGT GENETIC POLYMORPHISM
    Jun yan Hong; Fiscal Year: 2001
    ..It could have a significant impact on cancer prevention by identifying susceptible subpopulations in future epidemiological studies. ..
  60. Imbalancing DNA BER to enhance Ovarian Tumor Sensitivity
    Mark Kelley; Fiscal Year: 2008
    ..of the human apurinic/apyrimidinic endonuclease (APE1) enzyme, overexpression of N-methylpurine DNA glycosylase (MPG), both targeted to the nucleus and mitochondria, as well as small (short) interfering RNA (siRNA) for APE1...
  61. Enhancing Photodynamic Therapy for Treating Kaposi's Sarcoma
    Charles Gomer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. Viral vector-based RNAi therapy for Alexander Disease
    Daniel Bonthius; Fiscal Year: 2008
    ..The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. [unreadable] [unreadable] [unreadable]..
  63. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2010
    ..3) To test a hypothesis that Clp1 promotes actomyosin ring stability through effects on Cdc15. 4) To determine how Clp1 and the anaphase promoting complex promote Cdc25 inactivation in late mitosis. ..
  64. NDRG1 in squamous cell oesophageal cancer
    Denver Hendricks; Fiscal Year: 2008
    ..The effect of these deletions on the sub-cellular localization of NDRG1 and markers of tumorigenesis described above will be determined. [unreadable] [unreadable]..
  65. Hsp90 inhibitors as suppressors of protein misfolding toxicity
    Gabriela Chiosis; Fiscal Year: 2008
    ..In conclusion, Hsp90- interfering drugs represent a potential novel class of drugs to promote the survival of neurons and open up a promising approach to the treatment of neurodegenerative diseases. [unreadable] [unreadable] [unreadable]..
  66. Plainning malaria training in Zambia
    Thomas Eisele; Fiscal Year: 2009
    ..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
  67. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  68. MOLECULAR MECHANISMS OF MATRIX GLA PROTEIN
    KRISTINA BOSTROM; Fiscal Year: 2004
    ..Understanding the molecular mechanisms of MGP will provide information that is widely applicable to the development of vascular disease. ..
  69. FUNCT. CHARACTERIZATION OF HUMAN CYP2A6 GENETIC VARIANTS
    Jun yan Hong; Fiscal Year: 2002
    ....
  70. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  71. OXIDATIVE DNA DAMAGE AND REPAIR IN CNS CELLS
    Mark Kelley; Fiscal Year: 2003
    ..abstract_text> ..
  72. A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation to
    Christopher Haiman; Fiscal Year: 2007
    ..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
  73. Isolation of Inhibitors of Her-Kinase Expression (RMI)
    Gabriela Chiosis; Fiscal Year: 2005
    ..To our knowledge, this has not been accomplished, and we believe that we are uniquely positioned to initiate this goal. ..
  74. Vitamin K, Bone, and Arterial Calcification
    Reidar Wallin; Fiscal Year: 2006
    ..The proposed work will provide basic knowledge of BMP-2 growth factor mediated calcification as it is linked to the function of a fat-soluble vitamin (vitamin K) and biosynthesis of vitamin K-dependent proteins. ..
  75. Effect of Adenosine A2 receptor activation on the mitochondrial death pathway
    Zhelong Xu; Fiscal Year: 2010
    ....