MMP-9

Summary

Gene Symbol: MMP-9
Description: matrix metallopeptidase 9
Alias: CLG4B, GELB, MANDP2, MMP-9, matrix metalloproteinase-9, macrophage gelatinase, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), type V collagenase
Species: human

Top Publications

  1. pmc MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    T H Vu
    Department of Anatomy, University of California, San Francisco 94143, USA
    Cell 93:411-22. 1998
  2. pmc Association of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China
    Yanhong Cong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 15:1412-7. 2009
  3. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
  4. ncbi The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL
    L Yan
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:37258-65. 2001
  5. pmc MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    L M Coussens
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cell 103:481-90. 2000
  6. ncbi MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cancer Cell 2:289-300. 2002
  7. pmc Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women
    Barbara J Jefferis
    Department of Primary Care and Population Health, UCL Medical School, London, United Kingdom
    Atherosclerosis 208:557-63. 2010
  8. pmc KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9
    X Wang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA
    Oncogene 30:1901-11. 2011
  9. ncbi The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients
    Cecilia A Fernandez
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, MA, USA
    Clin Cancer Res 11:5390-5. 2005
  10. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011

Research Grants

  1. Regulation of endothelial MMP expression and function
    Zorina Galis; Fiscal Year: 2006
  2. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
  3. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
  4. Suresh C Tyagi; Fiscal Year: 2015
  5. 92K-GL (MMP 9) AND THE INVASIVE PHENOTYPE
    MARTIN BODDEN; Fiscal Year: 1999
  6. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
  7. Linda L Phillips; Fiscal Year: 2016
  8. KATHLEEN RAMAN; Fiscal Year: 2016
  9. Ana J Coito; Fiscal Year: 2014
  10. A novel function of TIMP-1
    Hyeong Reh Choi Kim; Fiscal Year: 2012

Patents

  1. Mmp-9 gene polymorphisms

Detail Information

Publications415 found, 100 shown here

  1. pmc MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    T H Vu
    Department of Anatomy, University of California, San Francisco 94143, USA
    Cell 93:411-22. 1998
    ..Growth plates from gelatinase B-null mice in culture show a delayed release of an angiogenic activator, establishing a role for this proteinase in controlling angiogenesis...
  2. pmc Association of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China
    Yanhong Cong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 15:1412-7. 2009
    ..To study the association of the single nucleotide polymorphisms (SNPs) rs17576 and rs2250889 in the extracellular matrix metalloprotease-9 (MMP-9) gene with primary angle closure glaucoma (PACG) in southern Chinese patients...
  3. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
    ..These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion...
  4. ncbi The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL
    L Yan
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:37258-65. 2001
    ..In summary, this study identifies the 125-kDa urinary gelatinase as being a complex of MMP-9 and NGAL and provides evidence that NGAL modulates MMP-9 activity by protecting it from degradation...
  5. pmc MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    L M Coussens
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cell 103:481-90. 2000
    ..Thus, inflammatory cells can be coconspirators in carcinogenesis...
  6. ncbi MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cancer Cell 2:289-300. 2002
    ..Thus, a block of MMP9 induction via VEGFR-1 inhibition could be useful for the prevention of tumor metastasis in lung...
  7. pmc Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women
    Barbara J Jefferis
    Department of Primary Care and Population Health, UCL Medical School, London, United Kingdom
    Atherosclerosis 208:557-63. 2010
    ..We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors...
  8. pmc KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9
    X Wang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA
    Oncogene 30:1901-11. 2011
    ..Taken together, this work identified the KLF8 activation of MMP9 as a novel and critical signaling mechanism underlying human breast cancer invasion and metastasis...
  9. ncbi The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients
    Cecilia A Fernandez
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, MA, USA
    Clin Cancer Res 11:5390-5. 2005
    ..Based on our previous reports that MMPs can be detected in the urine of cancer patients, we also asked whether MMP-9/NGAL could be detected in the urine of breast cancer patients and whether it might be predictive of disease status...
  10. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011
    ..An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective...
  11. ncbi Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytes
    Jeanette A Ardans
    Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 71:1012-8. 2002
    ..These data suggest that the interaction of primary monocytes with ox-LDL and proinflammatory cytokines may contribute to vascular remodeling and plaque rupture...
  12. pmc Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
    Marianne Strazza
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1399:96-115. 2011
    ....
  13. ncbi Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 107:1579-85. 2003
    ..However, epidemiological data evaluating the prognostic impact of circulating concentrations and functional genetic variations of MMP-9 are lacking...
  14. pmc A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Physiol 216:405-12. 2008
    ..Taken together, our data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of MMPs, in particular MMP-2 and MMP-9, and EGFR-activated signaling...
  15. doi Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects
    Peter McColgan
    Imperial College Cerebrovascular Research Unit, Imperial College London, Hammersmith Hospitals, London, United Kingdom
    Int J Cancer 125:1473-8. 2009
    ..Subjects with the MMP-1 nt-1607 polymorphism have an increased association with colorectal cancer. Those homozygous for either the MMP-2/1306T or 735T allele may be at reduced risk of lung cancer, although the evidence base is small...
  16. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
    ....
  17. doi Adiposity and low-grade systemic inflammation modulate matrix metalloproteinase-9 levels in Greek children with sleep apnea
    Athanasios G Kaditis
    University of Thessaly, School of Medicine, Larissa, Greece
    Pediatr Pulmonol 45:693-9. 2010
    ..The aim of this investigation was to evaluate the association of severity of OSA, adiposity, and CRP with MMP-9 plasma levels in Greek children...
  18. ncbi CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12
    Sreenivasa R Chinni
    Department of Urology, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Prostate 66:32-48. 2006
    ..Recent evidence suggests that similar mechanisms may be active in cancer metastasis. Previously, we showed that metalloproteases (MMPs), and in particular MMP-9, play a role in prostate cancer (PC) expansion in bone...
  19. pmc ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer
    Li fang Lin
    Institute of Basic Medical Sciences, National Cheng Kung University, Department of Pathology, Tainan, Taiwan
    Cancer Res 70:192-201. 2010
    ..Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression...
  20. doi Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder
    Pichili Vijaya Bhaskar Reddy
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Neurochem Res 37:1697-706. 2012
    ..Taken together, these results suggest a possible protective role of Nrf2 in regulating the levels of pro-oxidative and pro-inflammatory molecules in HAND...
  21. doi META060 attenuates TNF-α-activated inflammation, endothelial-monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes
    Anuradha Desai
    Metagenics, Inc, Gig Harbor, WA 98332, USA
    Atherosclerosis 223:130-6. 2012
    ..A modified hop extract, META060, was identified as an inhibitor of inflammatory mediators in human rheumatoid arthritis synovial fibroblasts...
  22. doi Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    Karine Lolmede
    Clinical Cardiovascular Biology Research Center, H San Raffaele Scientific Institute, Milano, Italy
    J Leukoc Biol 85:779-87. 2009
    ..Moreover, they open the possibility of novel strategies, aimed at interfering selectively with signals that recruit blood-derived stem cells toward pro- or anti-inflammatory macrophages...
  23. ncbi The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer
    Taku Takeuchi
    Department of Surgery, Nara Medical University, Kashihara City, Nara, Japan
    Clin Cancer Res 10:5572-9. 2004
    ..However, the clinical relevance of these findings remains to be fully documented. Here we examined the expression of RECK and one of its targets, MMP-9, in colorectal cancer tissue...
  24. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008
    ..In this study, increased mMUC5AC transcripts and protein were associated with increased lung matrix metalloproteinase 9 (mMMP9) transcripts, protein, and activity in acrolein-exposed mice...
  25. doi Matrix metalloproteinase-9 is associated with relapse and prognosis of patients with colorectal cancer
    Dake Chu
    State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, Shaanxi, China
    Ann Surg Oncol 19:318-25. 2012
    ..The present study aims to examine MMP-9 expression in human colorectal cancer and to determine its association with clinicopathological characteristics and prognosis...
  26. doi Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer
    Vesna V Dragutinović
    Institute of Medical Chemistry, School of Medicine, University of Belgrade, Visegradska 26, Belgrade, Serbia
    Mol Cell Biochem 355:173-8. 2011
    ..Detection of MMP-2 and MMP-9 in serum might be useful for identification of patients with higher risk for colorectal cancer recurrence...
  27. doi Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts
    Gustavo Ramirez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Lab Invest 91:1206-18. 2011
    ..These findings indicate that loss of Thy-1 in human lung fibroblasts induces a fibrogenic phenotype...
  28. pmc PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    FASEB J 25:3979-88. 2011
    ..Overall, our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells...
  29. doi HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9
    Ruifen Xu
    Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
    Brain Res 1436:13-9. 2012
    ..Taken together, these results show that the HIV-1 Tat protein disrupts BBB integrity, at least in part by decreasing the production of occludin...
  30. pmc Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1
    Lisa A Ridnour
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Neurochem 123:736-49. 2012
    ..Aβ) peptides that are metabolized into products, including Aβ1-16, by proteases including matrix metalloproteinase 9 (MMP-9)...
  31. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  32. ncbi Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells
    Syng Ook Lee
    Department of Food Science and Technology and The Center for Traditional Microorganism Resources TMR, Keimyung University, Daegu 704 701, Republic of Korea
    Biochem Biophys Res Commun 354:165-71. 2007
    ..These results suggest that silibinin represents a potential anti-metastatic agent suppressing PMA-induced cancer cell invasion through the specific inhibition of AP-1-dependent MMP-9 gene expression...
  33. ncbi Safety profile of tissue plasminogen activator treatment among stroke patients carrying a common polymorphism (C-1562T) in the promoter region of the matrix metalloproteinase-9 gene
    Joan Montaner
    Neurovascular Research Laboratory, Stroke Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 34:2851-5. 2003
    ....
  34. doi Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
    Javier Redondo-Muñoz
    Centro de Investigaciones Biologicas, Madrid, Spain
    Cancer Cell 17:160-72. 2010
    ..Our results establish that MMP/receptor binding induces intracellular survival signals and highlight the role of (pro)MMP-9 in B-CLL pathogenesis...
  35. ncbi Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells
    Ha Young Lee
    Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong A University, Busan 602 714, Republic of Korea
    Biochem Biophys Res Commun 330:989-98. 2005
    ..Taken together, we suggest that SAA plays a role in the modulation of inflammatory and immune responses via FPRL1, by inducing MMP-9 upregulation in human monocytic cells...
  36. ncbi Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta
    Christina H Stuelten
    Laboratory of Cell Regulation and Carcinogenesis, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 118:2143-53. 2005
    ..Together, our results indicate that MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk, involving multiple ligands and cellular signaling pathways...
  37. ncbi Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration
    Javier Redondo-Muñoz
    Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid
    Blood 111:383-6. 2008
    ..These results strongly suggest that MMP-9 is involved in B-CLL nodal infiltration and expand the roles of MMP-9 and CCR7 in B-CLL progression. Both molecules could thus constitute therapeutic targets for this disease...
  38. ncbi Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model
    Odete Mendes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Clin Exp Metastasis 22:237-46. 2005
    ..In addition, PD 166793 decreased the in vitro invasive cell behavior of ENU1546. Together our results suggest that MMP-2, -3 and -9 may be involved in the process of metastasis of breast cancer to the brain...
  39. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
    ....
  40. doi Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population
    Shin Yup Lee
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Respiration 80:133-8. 2010
    ..Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent...
  41. doi Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells
    Javier Redondo-Muñoz
    Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Blood 112:169-78. 2008
    ..Thus, we have identified alpha4beta1 and CD44v as a novel proMMP-9 cell surface docking complex and show that cell-associated MMP-9 may regulate B-CLL cell migration and arrest...
  42. pmc Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
    Melanie Rolli
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:9482-7. 2003
    ..These molecules cooperate to enhance breast cancer cell migration toward specific matrix proteins, and this may contribute to the strongly enhanced metastatic capacity of breast cancer cells that express activated alphavbeta3...
  43. ncbi Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway
    J C H Cheng
    Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    Oncogene 25:7009-18. 2006
    ..Taken together, our results indicated that sublethal dose of radiation could enhance HCC cell invasiveness by MMP-9 expression through the PI3K/Akt/NF-kappaB signal transduction pathway...
  44. ncbi MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
    Javier Redondo-Muñoz
    Departamento de Inmunologia, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Blood 108:3143-51. 2006
    ..MMP-9 could therefore constitute a target for treatment of this malignancy...
  45. ncbi Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells
    Jaime Symowicz
    Departments of Cell and Molecular Biology and Pathology, Northwestern University Feinberg Medical School, Chicago, IL, USA
    Cancer Res 67:2030-9. 2007
    ..These data support a novel mechanism for posttranslational modification of E-cadherin function via MMP-9 induction initiated by cell-matrix contact and suggest a mechanism for promotion of EOC metastatic dissemination...
  46. pmc Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors
    Asmaa B Hamze
    College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Protein Sci 16:1905-13. 2007
    ..8 and 0.4 nM for MMP-2 and -9, respectively. Interestingly, the Gly mutant has a Ki of 2.1 nM for MMP-9 and >40 muM for MMP-2, indicating that engineered TIMPs can discriminate between MMPs in the same subfamily...
  47. doi Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer
    Soon Young Park
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 302 718, Republic of Korea
    Oncol Rep 25:1677-81. 2011
    ..By developing HDAC isoforms as potential biomarkers for breast cancer metastasis, the present study can be extended to developing therapies for breast cancer invasion...
  48. ncbi Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories
    Stella B Somiari
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Int J Cancer 119:1403-11. 2006
    ..Independent validation based on the leave-one-out cross validation approach gave an overall classification of 63%. Our study provides evidence supporting the potential role of serum MMP2/9 as biomarkers for breast disease classification...
  49. doi Role of MMP9 on invadopodia formation in cells from adenoid cystic carcinoma. Study by laser scanning confocal microscopy
    Camila F Nascimento
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Microsc Res Tech 73:99-108. 2010
    ..Our results showed that CAC2 cells exhibit functional invadopodia containing cortactin and MT1-MMP. Furthermore, MMP9 would be required in the initial steps of invadopodia formation...
  50. pmc Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
    J Clin Invest 110:625-32. 2002
    ..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA...
  51. pmc A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
    ..Expression and activity of matrix metalloproteinase 9 (MMP-9), a major effector of ECM turnover, is up-regulated in the inflamed conjunctiva of trachoma ..
  52. doi High MMP-9 activity levels in fragile X syndrome are lowered by minocycline
    Magdalena Dziembowska
    Nencki Institute, Warsaw, Poland
    Am J Med Genet A 161:1897-903. 2013
    ..The results of this study suggest that, in humans, activity levels of MMP-9 are lowered by minocycline and that, in some cases, changes in MMP-9 activity are positively associated with improvement based on clinical measures...
  53. ncbi Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons
    B Bauvois
    Unite 365 INSERM, Section de Recherche, Institut Curie, Pavillon Pasteur, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Leukemia 16:791-8. 2002
    ..IFNs however did not affect the production of bFGF, VEGF and TNF-alpha. Together, our data show that B-CLL lymphocytes synthesize MMP-9 and emphasize the specific inhibitory actions of IFNs on its expression...
  54. pmc Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 96:211-9. 2010
    ..0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans...
  55. pmc Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street Room 255 Philadelphia, PA 19107, USA
    ScientificWorldJournal 2012:482575. 2012
    ....
  56. pmc IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9
    Qiaojia Huang
    Department of Experimental Medicine, Fuzhou General Hospital Dongfang Hospital, 156 North Xi er Huan Road, Fuzhou City, Fujian Province 350025, China
    Mol Cancer 13:18. 2014
    ..P38 and JNK are the major MAPK family members that regulate IL-1β signaling pathways. Here, we investigated the role of both p38 and JNK in IL-1β-induced GA cell migration, invasion and metastatic potential...
  57. pmc Eosinophil inflammation of nasal polyp tissue: relationships with matrix metalloproteinases, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta1
    Young Mok Lee
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    J Korean Med Sci 18:97-102. 2003
    ..Close correlations were noted between TGF-beta1, and MMP-9 and MMP-2, but not with TIMP-1. MMP-2, MMP-9, and TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue...
  58. ncbi The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1
    Koichi Hattori
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, Room D601 New York, NY 10021, USA
    Leuk Lymphoma 44:575-82. 2003
    ..These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting...
  59. ncbi Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression
    Tanya L Medley
    Alfred and Baker Medical Unit, Baker Medical Research Institute, University of Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 24:1479-84. 2004
    ..This study examined whether matrix metalloproteinase (MMP)-9 (gelatinase B) genotype is associated with large artery stiffening and aortic MMP-9 gene and protein expression...
  60. ncbi Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge Addenbrooke s Hospital Cambridge, United Kingdom
    Arterioscler Thromb Vasc Biol 25:372. 2005
    ..We hypothesized that elastase activity would be related to arterial stiffness and tested this using isolated systolic hypertension (ISH) as a model of stiffening and separately in a large cohort of healthy individuals...
  61. ncbi Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells
    SaHyun Hong
    Department of Pathology and Department of Obstetrics and Gynecology, College of Medicine, Catholic University of Daegu, Daegu 705 034, Korea
    J Biol Chem 280:25202-9. 2005
    ..In conclusion, ascochlorin represents a unique natural anti-tumor compound that specifically inhibits MMP-9 activity through suppression of AP-1-dependent induction of MMP-9 gene expression...
  62. ncbi Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment
    C Avolio
    Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Mult Scler 11:441-6. 2005
    ..85; P < 0.05) of the numbers of MRI Gd-TD active lesions. These data confirm that serum MMP-9/TMIP-1 ratio may be viewed as a reliable marker and may be predictive of MRI activity in RR MS...
  63. pmc Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study
    Julio Rodriguez-Lopez
    Research Laboratory 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 8:R1. 2006
    ....
  64. pmc Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity
    Mineo Iwata
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 109:85-92. 2007
    ..001). We conclude that monocytes can express MMP-9 in response to stromal factors and that this response may be significantly decreased in MDS-derived monocytes...
  65. pmc Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
    Bilal Bin Hafeez
    Department of Dermatology, University of Wisconsin, 1300 University Avenue, Medical Science Center, B 25, Madison, WI 53706, USA
    Clin Cancer Res 15:452-9. 2009
    ..Because Notch1 was found to be overexpressed in prostate cancer (PCa) cells and human PCa tissue, we therefore tested our hypothesis that overexpression of Notch1 in PCa promotes tumor invasion...
  66. pmc Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells
    Xiaolin Sun
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Carcinogenesis 30:2109-16. 2009
    ..Taken together, these results indicate that the Abi1 signaling plays a critical role in breast cancer progression and suggest that this pathway may serve as a therapeutic target for the treatment of human breast cancer...
  67. pmc Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis
    Fiia P Gäddnäs
    Department of Anesthesiology, Division of Intensive Care, Oulu University Hospital, Kajaanintie 50, Oulu, Finland
    Crit Care 14:R49. 2010
    ..The aim of this study was to investigate the timely development of serum and skin MMP-2, -8 and -9 levels in human severe sepsis and their association with disease severity and mortality...
  68. doi Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort
    Priyanka Srivastava
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Ann Surg Oncol 17:3068-75. 2010
    ..To test this proposition we examined whether six SNPs of the MMP-3 and MMP-9 genes are associated with risk of bladder cancer (BC) in a North Indian population...
  69. doi Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1
    Yu Chen
    State Key Laboratory of Cancer Biology and Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Int J Cancer 129:1586-98. 2011
    ..Gelatin zymography and Western blot showed that instead of regulating matrix metalloproteinase 9 (MMP9) expression, RUNX3 expression inhibited MMP9 enzyme activity, and this was consistent with the ..
  70. pmc Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer
    Jean Luc Brun
    Department of Obstetrics, Hopital Tenon, AP HP, F 75571 Paris, France
    Oncol Rep 27:1049-57. 2012
    ..Standard statistical analysis adjusted after Bonferroni correction and CMDS reduced the relevance of MMPs and TIMPs in the prognosis of patients with advanced ovarian cancer...
  71. doi Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse
    Maria Maddalena Ferrari
    Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Arch Gynecol Obstet 285:1581-6. 2012
    ..To evaluate whether the presence of specific polymorphism in the gene promoter of collagen and some matrix metalloproteinases was associated with the risk of developing pelvic organ prolapse...
  72. pmc AP-1 mediated transcriptional repression of matrix metalloproteinase-9 by recruitment of histone deacetylase 1 in response to interferon β
    Megan L Mittelstadt
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 7:e42152. 2012
    ..Altogether, our results establish that the repression of MMP-9 transcription in response to IFNβ occurs by the recruitment of HDAC1 via the proximal AP-1 binding site...
  73. pmc Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm
    Tyler Duellman
    Molecular and Cellular Pharmacology Graduate Program, University of Wisconsin School of Medicine and Public Health, 1300 University Ave, Madison, WI 53706, USA
    Circ Cardiovasc Genet 5:529-37. 2012
    ....
  74. doi Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway
    Xiaolei Li
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi 710032, P R China
    Int J Oncol 43:793-802. 2013
    ..These data demonstrate that Bmi-1 plays a vital role in HCC invasion and that Bmi-1 is a potential therapeutic target for HCC...
  75. pmc Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9
    Ewa Zajac
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA
    Blood 122:4054-67. 2013
    ..Our study provides a unifying molecular mechanism for high angiogenic capacity of TIMP-free proMMP-9 that would be uniquely produced in a pathophysiological microenvironment by influxing neutrophils and/or M2 polarized macrophages. ..
  76. pmc Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells
    Hee Cheol Kim
    Biomedical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea
    Oncotarget 5:519-29. 2014
    ..an effect mediated by extracellular signal-regulated kinase (ERK)-dependent upregulation of matrix metalloproteinase 9 (MMP9)...
  77. doi Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis
    Hisato Takagi
    Department of Cardiovascular Surgery, Shizuoka Medical Center, Sunto gun, Shizuoka 411 8611, Japan
    Interact Cardiovasc Thorac Surg 9:437-40. 2009
    ..We found that, based on a systematic review and meta-analysis, circulating MMP-9 concentrations are higher in patients with AAA than those in subjects without AAA. Higher circulating MMP-9 concentrations are associated with AAA presence...
  78. ncbi Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer
    N Inagaki
    Reproductive Biology Unit, The Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Hum Reprod 18:608-15. 2003
    ..This question was addressed by measuring cytokine concentrations and matrix metalloproteinase activities in fluid derived from uterine irrigation of such patients...
  79. ncbi RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion
    Irina Abécassis
    INSERM U496, Hopital Saint Louis, 1 Ave C Vellefaux, 75010, Paris, France
    Exp Cell Res 291:363-76. 2003
    ..We propose that RhoA triggers signalling pathways that, upregulating expression of a proteinase at specific membrane localizations, may confer an highly invasive phenotype to endothelial cells...
  80. ncbi Matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions correlate with the recurrence of intracranial meningiomas
    Masaki Okada
    Department of Neurological Surgery, Kagawa Medical University, Kita County, Kagawa, Japan
    J Neurooncol 66:29-37. 2004
    ..We studied whether or not the expressions of MMP-2 and MMP-9 were correlated with the proliferative potential or recurrence of intracranial meningiomas...
  81. ncbi Class II major histocompatibility complex transactivator (CIITA) inhibits matrix metalloproteinase-9 gene expression
    Susan Nozell
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    J Biol Chem 279:38577-89. 2004
    ....
  82. pmc The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer
    Aparna A Kamat
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Clin Cancer Res 12:1707-14. 2006
    ..We sought to determine the role of epithelial (tumor cell-derived) and stromal (host-derived) expression of MMPs in predicting the clinical outcome of patients with epithelial ovarian cancer (EOC)...
  83. ncbi Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer
    Nils Elander
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping, Sweden
    Anticancer Res 26:791-5. 2006
    ..Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC)...
  84. ncbi Angiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cells
    Wei Huang
    Department of Gastroenterology, Ruijin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Dig Dis Sci 53:163-8. 2008
    ..These results suggest that AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP2 and MMP9...
  85. doi The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells
    Ling Li
    CHUM Research Centre, Notre Dame Hospital, Department of Medicine, University of Montreal, Quebec, Canada
    Atherosclerosis 204:40-6. 2009
    ..These results demonstrate that gliclazide inhibits endothelial LOX-1 expression and prevents LOX-1-mediated proatherogenic effects associated with endothelial dysfunction and plaque rupture...
  86. doi Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease
    Shih Lung Cheng
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    Biochem Genet 47:591-601. 2009
    ..Combinations of genetic variants including *2A homozygotes of CYP1A1 and T alleles in MMP-9 are significant indicators for susceptibility to COPD. The homozygous *2A allele of CYP1A1 is an independent risk factor for very severe COPD...
  87. ncbi Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease
    J Safranek
    Departments of Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, University Hospital in Pilsen, Czech Republic
    Anticancer Res 29:2513-7. 2009
    ....
  88. doi Clinical significance of the measurements of serum matrix metalloproteinase-9 and its inhibitor (tissue inhibitor of metalloproteinase-1) in patients with pancreatic cancer: metalloproteinase-9 as an independent prognostic factor
    Barbara Mroczko
    Department of Biochemical Diagnostics, Medical University, Bialystok, Poland
    Pancreas 38:613-8. 2009
    ..The aim of the study was to determine the diagnostic and prognostic significance of the measurements of serum MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with PC...
  89. ncbi Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions
    S Vatansever
    Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey
    Clin Invest Med 32:E293-300. 2009
    ..To investigate diagnostic values of pleural fluid matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1) and TIMP-2 measurements in tuberculous pleurisy(TP) and malignat pleurisy (MP)...
  90. doi Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas
    Gamze Donmez
    Adana Numune Education and Research Hospital, Department of Pathology, Adana, Turkey
    Pathol Res Pract 205:854-7. 2009
    ..014, r=-0.21). Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma...
  91. pmc Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population
    Imran Haq
    School of Molecular Medical Sciences, Institute of Genetics, Queen s Medical Centre, University of Nottingham, UK
    BMC Med Genet 11:7. 2010
    ..Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting associations of both single nucleotide polymorphisms (SNPs) and SNP haplotypes, plausibly due to under-powered studies...
  92. pmc The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
    P Bhoopathi
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA
    Br J Cancer 102:530-40. 2010
    ..We therefore sought to determine the effect of SPARC expression on medulloblastoma tumour growth and angiogenesis...
  93. pmc Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus
    Kathryn M Thrailkill
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA
    Endocrine 37:336-43. 2010
    ....
  94. pmc Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study
    Stefan Lakemeier
    Department of Orthopedics and Rheumatology, University Hospital Marburg, Marburg, Germany
    BMC Musculoskelet Disord 11:271. 2010
    ..We compared expression of these MMPs in both LHB and healthy tendon samples...
  95. pmc Methamphetamine and HIV-1 gp120 effects on lipopolysaccharide stimulated matrix metalloproteinase-9 production by human monocyte-derived macrophages
    Jessica L Reynolds
    Departments of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Innovation Center, USA
    Immunol Invest 40:481-97. 2011
    ..Collectively methamphetamine and gp120 effects on MMPs may modulate remodeling of the extracellular environment enhancing migration of monocytes/macrophages to the CNS...
  96. pmc Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population
    Mona S Awadalla
    Ophthalmology Department, Flinders University, Adelaide, South Australia, Australia
    Mol Vis 17:1420-4. 2011
    ..To investigate the association between genetic variation at the matrix metalloproteinase-9 (MMP9) locus and primary angle closure glaucoma (PACG) in an Australian Caucasian population...
  97. pmc MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    Shivani Ponnala
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:2065-75. 2011
    ..Taken together, these data provide new insights into the mechanisms underlying MMP-9-mediated hTERT expression in glioma proliferation...
  98. doi Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells
    Antonia Patruno
    Department of Drug Sciences, University G D Annunzio, Chieti, Italy
    J Cell Physiol 227:2767-74. 2012
    ..These results may suggest a pathway connecting an imbalance of MMPs and their cognate inhibitor TIMP-1...
  99. pmc ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3
    Sonali Ghosh
    Cell Biology and Physiology Division, CSIR Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, 4 Raja S C Mullick Road, Kolkata 700032, India
    J Biol Chem 287:15001-15. 2012
    ..The study provides a mechanistic insight into the prometastatic functions of VEGF-induced expression of relevant MMPs...
  100. doi Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy
    Nathalie Bednarek
    INSERM, Hopital Robert Debre, Paris, France
    Pediatr Res 71:63-70. 2012
    ..We evaluated the effectiveness of matrix metalloproteinases (MMPs) and their naturally occurring tissue inhibitors of metalloproteinases (TIMPs) in predicting neonatal encephalopathy (NE) damage in newborns...
  101. ncbi MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture
    S J Fortunato
    Perinatal Research Center, Women s Health Research and Education Foundation, Nashville, TN, USA
    J Perinat Med 27:362-8. 1999
    ..This study examines the levels of the gelatinases and their natural inhibitors (tissue inhibitor of matrix metalloproteinases-TIMPs) in the amniotic fluid during PROM, preterm labor (PTL) and at term...

Research Grants85

  1. Regulation of endothelial MMP expression and function
    Zorina Galis; Fiscal Year: 2006
    ..abstract_text> ..
  2. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ....
  3. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
    ..Many chronic pain conditions are inadequately alleviated by available medications. This proposal will examine the role of matrix metalloproteinases in the onset and the duration of pain sensations. ..
  4. Suresh C Tyagi; Fiscal Year: 2015
    ..The positive outcome of this project will have therapeutic ramifications for chronic heart failure. ..
  5. 92K-GL (MMP 9) AND THE INVASIVE PHENOTYPE
    MARTIN BODDEN; Fiscal Year: 1999
    ..The combination of the studies proposed in this application will provide a better understanding of the role of 92K-GL and TIMP-l, as well as other MMPs, in the invasive phenotype of human cancers of oral and other origins. ..
  6. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
    ..Inhibiting MMP-1 gene expression may, therefore, be useful in therapeutically controlling melanoma metastasis. ..
  7. Linda L Phillips; Fiscal Year: 2016
    ..These studies are likely to identify novel options for regional and fiber targeted therapy in patients suffering from axonal damage after TBI. ..
  8. KATHLEEN RAMAN; Fiscal Year: 2016
    ..The clinical relevance of this proposal is underscored by the increasing incidence of AAAs among the VA population and the limited treatment options that are currently available. ..
  9. Ana J Coito; Fiscal Year: 2014
    ....
  10. A novel function of TIMP-1
    Hyeong Reh Choi Kim; Fiscal Year: 2012
    ..This information may also be useful for the development of novel approaches for targeting TIMP-1's signaling activity versus its MP inhibitory activity. ..
  11. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2010
    ..Moreover, we will assess the function of Timp-1 overexpression as a therapeutic approach in partial liver IRI and in steatotic OLT. ..
  12. Suresh C Tyagi; Fiscal Year: 2016
    ..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page ..
  13. A Brent Carter; Fiscal Year: 2015
    ..abstract_text> ..
  14. Targeting Matrix Metalloproteinases for Tumor Imaging
    Carolyn Anderson; Fiscal Year: 2004
    ..If successful, the outcome of this study may be a PET tracer for determining the metastatic potential of various types of cancer. ..
  15. Suresh C Tyagi; Fiscal Year: 2016
    ..The results of the proposed research should uncover the molecular mechanisms regulating Hcy-Fg-Ab-collagen complex formation and lead to effective strategies for the treatment of cerebrovascular complications during diseases such as AD. ..
  16. Matrix Metalloproteinases and Cocaine
    Barbara A Sorg; Fiscal Year: 2012
    ..These studies will have a positive impact on the drug abuse field because they will determine the potential for using MMP inhibitors to disrupt reconsolidation of cocaine memories that may underlie chronic relapse. ..
  17. Zena Werb; Fiscal Year: 2016
    ..mechanisms of this complex interplay between malignant cancer cells and the surrounding non- malignant stroma represents one of the major challenges in cancer research, which once understood, will foster new approaches to cancer therapy, ..
  18. Conor C Lynch; Fiscal Year: 2014
    ..abstract_text> ..
  19. Gregg B Fields; Fiscal Year: 2016
    ....
  20. Innate Immunity in Acne Vulgaris
    Jenny J Kim; Fiscal Year: 2013
    ....
  21. The Role of Extracelluar Enzymes in Regulating Corneal Repair
    Matilda Frances Chan; Fiscal Year: 2012
    ....
  22. Jihe Zhao; Fiscal Year: 2014
    ..Completion of this project will shed new lights on mechanisms responsible for breast cancer metastasis which may leads to new therapeutic intervention. ..
  23. Ling Qin; Fiscal Year: 2014
    ..In addition, as a new investigator, I will be greatly benefited from this award by generating preliminary data to be used for competing future research supports. ..
  24. Judith A West-Mays; Fiscal Year: 2015
    ..Ultimately, our goal is to define the TGF[unreadable]- mediated pathways controlling EMT and fibrosis in ASC and PCO in order to design therapeutics for mitigating these diseases. ..
  25. Veronica Shubayev; Fiscal Year: 2016
    ..This porgram is designed to expedite the development and implementation of novel therapies to neurodegenerative diseases. ..
  26. WILLIAM RAMSES BISHAI; Fiscal Year: 2016
    ..This study will identify the specific mechanisms and inflammatory processes that are subverted by bacterial cyclic-AMP secretion in order to identify targets in the host and the microbe that may be interrupted. ..
  27. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  28. Lipid Nanoparticle Mediated Inhibition and Detection of Matrix Metalloproteinases
    Sanku Mallik; Fiscal Year: 2012
    ..The successful completion of this research will establish foundation for developing diagnostic and therapeutic tools for other proteins responsible for causing different human diseases. ..
  29. JOSEPH KOFI AGYIN; Fiscal Year: 2014
    ..Together, these screens will provide validation for bone-targeted tumor-activated prodrugs as an effective treatment modality for treatment of MM and other bone metastatic cancers. ..
  30. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..The purpose of this proposal is to examine how 3-synuclein affects prosurvival/prodeath signaling and how it is implicated in MMP-9 regulation in glaucoma. ..
  31. TYPE V COLLAGENASE IN RHEUMATOID ARTHRITIS
    Tayebeh Pourmotabbed; Fiscal Year: 2001
    ..b>Type V collagenase/gelatinase B is a member of this multigene family of enzymes which exhibits high specificity for denatured ..
  32. Peter Libby; Fiscal Year: 2016
    ..g. mineralocorticid receptor blocking agent or statin administration) affect matrix metabolism in humans in vivo. ..
  33. Trauma to Developing Brain-Injury and Repair Mechanisms
    Linda J Noble; Fiscal Year: 2013
    ..Together, these studies provide an important foundation for understanding the unique vulnerability of the young brain to TBI and for developing the most appropriate therapies for the brain-injured child. ..
  34. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2012
    ..Defining how HCMV impairs EVT invasion is of major importance to the reproductive community and may provide additional therapeutic targets to maintain viable pregnancy. ..
  35. Aortic Aneurysm Formation: Mechanisms of Oxidative Stress-Induced MMP Expression
    MATTHEW JEREMIAH EAGLETON; Fiscal Year: 2012
    ..A better understanding of the pathogenesis of AAA formation could lead to the development of pharmacotherapies used to prevent aneurysm expansion and rupture. ..
  36. Crevicular Fluid Content During Early Wound Healing- Implant versus Tooth
    Binnaz Leblebicioglu; Fiscal Year: 2010
    ..This model will allow investigation of early stages of wound healing prior to soft tissue seal maturation without altering actual treatment protocol. ..
  37. PIA JOHANNA HAUK; Fiscal Year: 2014
    ..If bacteria in the airways of children with asthma cause more severe disease, antibiotics may have to be considered more often as therapy. ..
  38. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010
    ..The information that will be gained from this study is essential for the successful discovery of biological processes that impact on cognitive function in SLE that could be potentially amenable to disease-reversing therapies. ..
  39. Elena I Deryugina; Fiscal Year: 2016
    ..The results will be then validated in a number of murine models of angiogenesis and metastasis including orthotopic transplants and transgenic models focusing on the human disease-like TRAMP model. ..
  40. MOLECULAR MECHANISMS OF ANEURYSMAL DEGENERATION
    Robert Thompson; Fiscal Year: 2009
    ..Taken together, these studies will contribute important new information on the mechanisms underlying extracellular matrix degradation in aneurysmal degeneration. ..
  41. Chemoprevention of Head &Neck Cancer Using Controlled Release Polymers
    Susan R Mallery; Fiscal Year: 2013
    ..abstract_text> ..
  42. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ....
  43. Sanjay Misra; Fiscal Year: 2016
    ..The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy. ..
  44. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  45. Intervention of Disease by Selective Gelatinase Inhibitors
    Shahriar Mobashery; Fiscal Year: 2011
    ..The present grant application attempts to bring forward members of this type of drug forward for preclinical development. ..
  46. William P Fay; Fiscal Year: 2016
    ..We anticipate that the information gained from our experiments will lead to new strategies to treat and prevent vein graft disease. ..
  47. Physiology of Respiratory Muscle Micromechanics
    ALADIN BORIEK; Fiscal Year: 2009
    ..The completion of these aims will significantly contribute to the fundamental understanding of mechanical signal transduction in the respiratory pump. ..
  48. Targeting MT-MMPs in Cancer Progression
    RAFAEL A FRIDMAN; Fiscal Year: 2013
    ..Therefore, understanding the biological factors promoting these processes and developing therapies aimed at reducing tumor spread is of great clinical significance. ..
  49. Edward B Garon; Fiscal Year: 2015
    ..At the conclusion of this research training, I will be well positioned to function as an independent physician scientist in patient-oriented lung cancer research, and I anticipate competing for independent research funding. ..
  50. Merry L Lindsey; Fiscal Year: 2016
    ..Our multi-faceted approach will further advance the mechanistic understanding of the events that initiate post-MI LV remodeling, which may provide targets for translational research. ..
  51. Maintenance of Ocular Surface Integrity
    M Elizabeth Fini; Fiscal Year: 2006
    ..In the past grant period, this project focused on the role of Matrix Metalloproteinase (MMP) gelatinase B (gelB; MMP-9), expression of which is induced at the front of the corneal epithelium migrating to resurface a wound...
  52. Determining the Effect of Altered Pulse Pressure on Artery Structure and Function
    DANIKA HAYMAN; Fiscal Year: 2010
    ..Ultimately this knowledge will improve vascular disease treatment. ..
  53. The Role of Gelatinase B in Terminal Airway Remodeling
    Robert Senior; Fiscal Year: 2005
    ..Taken together, the studies proposed will contribute to better understanding of the biology of terminal airway epithelium, a site that is central in many chronic lung disorders, especially COPD. ..
  54. The role of Mycobacterium marinum protein ESAT-6 in promoting granuloma formation
    Frances Chu; Fiscal Year: 2011
    ..These experiments may lead to the discovery and characterization of new host drug targets and reduce the time required to treat drug-resistant tuberculosis infections. ) ..
  55. Xiaoying Wang; Fiscal Year: 2014
    ..We believe our proposal should be directly relevant for PA-07-233, "Multidisciplinary Translational Research in Critical Care" (R01). ..
  56. Concerted role for integrin alpha3beta1 and TGFb signaling in cancer progression
    Sita Subbaram; Fiscal Year: 2013
    ..These studies will contribute towards the understanding of malignant progression and lead to the development of novel therapies against metastatic cancer. ..
  57. ANTISENSE INHIBITORS FOR TREATMENT OF MULTIPLE SCLEROSIS
    Duane Ruffner; Fiscal Year: 2002
    ..There exists no cure for MS. Gelatinase-B also known as matrix metalloproteinase 9 (MMP-9), has been implicated in the pathogenesis of MS...
  58. Mathematical Modeling of Matrix Metalloproteinase-9 Driven Left Ventricular Remod
    Yufang Jin; Fiscal Year: 2010
    ....
  59. Regulation of Epithelial Cancer by MMP-9/gelatinase B
    Lisa Coussens; Fiscal Year: 2006
    ..Only a thorough understanding of the actions and effects of MMP-9 will effectively guide use of MMPIs in the treatment of cancer. ..
  60. GELATINASE B AND INFLAMMATORY BONE LOSS
    ANNE WUCHERPFENNIG; Fiscal Year: 1999
    ..enzyme in resorption, targeted disruption of the gelatinase B gene will be carried out to produce a mutant mouse (gelB-/-) (Aim 1). The skeletal structure of gelB-/- embryos will be examined in whole mount preparations...
  61. David H Wasserman; Fiscal Year: 2016
    ..Results from these studies will lead to a greater understanding of the sites involved in the dysregulation of muscle glucose uptake associated with insulin resistance and will identify potential treatment strategies. ..
  62. INTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVO
    David Wasserman; Fiscal Year: 2009
    ..Results from these studies will lead to a greater understanding of the sites involved in the dysregulation of muscle glucose uptake associated with insulin resistance and will identify potential treatment strategies. ..
  63. Linda J Noble; Fiscal Year: 2016
    ..Together, these studies provide an important foundation for understanding the unique vulnerability of the young brain to TBI and for developing the therapies that are specifically tailored to the brain-injured child. ..
  64. Sex Differences in Vascular Markers of Stroke Risk
    Cheryl D Bushnell; Fiscal Year: 2012
    ..This could naturally lead to development of a predictive panel of markers for future stroke risk. ..
  65. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ....
  66. Genetic Epidemiology of HAD Susceptibility Genes
    Sunil Ahuja; Fiscal Year: 2009
    ..110. We have submitted a request for addition of a new subtitle: "Genetic epidemiology of HIV-associated dementia". ..
  67. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  68. Jefferey L Burgess; Fiscal Year: 2014
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  69. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  70. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..The present study explores the usefulness of gene therapy to inhibit protease expression in conjunction with radiation for killing of medulloblastoma cells with lower toxicity. ..
  71. PROPERTIES OF OLFACTORY RECEPTORS - NEURAL REGENERATION
    RICHARD COSTANZO; Fiscal Year: 2009
    ..abstract_text> ..
  72. Pak H Chan; Fiscal Year: 2015
    ....
  73. Jamary Oliveira-Filho; Fiscal Year: 2015
    ..This work will also facilitate the development of novel anti-trypanosomal, anti- inflammatory, and antithrombotic strategies for stroke prevention and management in Brazil. ..
  74. STRAP and Smad 7 Signaling in Colorectal Carcinomas
    Pran K Datta; Fiscal Year: 2013
    ..A better understanding of these mechanisms will help to improve drug development and treatment of this lethal disease. ..
  75. J Marc Simard; Fiscal Year: 2016
    ..Demonstrating these concepts will advance our understanding of the fundamental cellular biology of stroke, and is anticipated to bring forth pharmaceutical treatments that will extend the treatment window and safety of tPA. ..
  76. Paras Kumar Mishra; Fiscal Year: 2016
    ..At translational level, the proposal will provide concrete evidence that over expression of miR-133 or ablation of MMP9 can ameliorate diabetic cardiomyopathy. ..
  77. Eng H Lo; Fiscal Year: 2015
    ..Our studies will dissect the molecular mechanisms involved, and determine the time course of when this good-to-bad switch occurs. ..
  78. EMMANUEL ANTONIO CRUZ; Fiscal Year: 2014
    ....
  79. Rajesh Agarwal; Fiscal Year: 2016
    ..In addition, these comprehensive study efforts will identify effective broad spectrum mechanism-based agent/s that alone or in combination provide effective therapies against vesicating agents-induced ocular injuries in humans. ..
  80. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. (End of Abstract) ..
  81. Carol M Troy; Fiscal Year: 2016
    ..Our preliminary data suggest that active caspase-9 regulates edema by decreasing the expression of matrix metalloproteinase 9 (MMP-9)...
  82. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..The objective of this proposal is to determine the mechanisms by which plasminogen regulates cell migration and, thereby, the inflammatory responses that contribute to thrombosis and CVD. ..
  83. Ahsan Husain; Fiscal Year: 2014
    ..The proposed identification of the downstream targets of chymase should provide a foundation for the development of novel therapeutic agents directed toward patients with cardiovascular disease. ..
  84. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..Identification of EPCs as an operant process in brain AVMs can suggest lines of investigation to develop new treatment modalities. ..
  85. Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    Zena Werb; Fiscal Year: 2006
    ..These studies will have direct implications for the treatment of skeletal injuries resulting from disease or malformation, and for injuries that are refractory to conventional therapy. ..

Patents1

  1. Mmp-9 gene polymorphisms
    Patent Number: WO9957315-A2; Date:1999-11-11