MMP-2

Summary

Gene Symbol: MMP-2
Description: matrix metallopeptidase 2
Alias: CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, 72 kDa type IV collagenase, collagenase type IV-A, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), matrix metalloproteinase-2, matrix metalloproteinase-II, neutrophil gelatinase
Species: human

Top Publications

  1. pmc The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    Hilary A Kenny
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1367-79. 2008
  2. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
  3. pmc A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Physiol 216:405-12. 2008
  4. pmc Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2
    Xiaojian Ni
    Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
    Cancer Sci 105:18-25. 2014
  5. doi Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
    Yuki Nishida
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
    Cancer Res 68:9096-104. 2008
  6. doi Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
    C X Zhou
    School of Dentistry and Oral Health and Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, Gold Coast, Queensland, Australia
    Aust Dent J 55:385-9. 2010
  7. ncbi Integrin alpha5beta1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity
    Galina Morozevich
    V N Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia
    Cell Cycle 8:2219-25. 2009
  8. ncbi The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily
    Georgina S Butler
    Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Center for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:15615-20. 2004
  9. doi Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population
    Hao Li
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, PR China
    Cerebrovasc Dis 30:618-25. 2010
  10. ncbi The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer
    Pornchai O-Charoenrat
    Department of Head and Neck Surgery, Faculty of Medicine, Siriraj Hospital Medical School, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand
    Oral Oncol 42:257-67. 2006

Research Grants

  1. Comparative Evaluation of Urinary Biological Markers for the Prognostic Stratific
    Bertrand Jaber; Fiscal Year: 2009
  2. Linda L Phillips; Fiscal Year: 2016
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
  4. Matam Vijay Kumar; Fiscal Year: 2015
  5. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
  6. MARK EDWARD WESTERMAN; Fiscal Year: 2014
  7. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
  8. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
  9. "Validation of Novel CKD Biomarkers in CRIC"
    Kathleen D Liu; Fiscal Year: 2013
  10. Subclinical and clinical heart disease and the effect on kidney injury and diseas
    Meyeon Park; Fiscal Year: 2013

Detail Information

Publications325 found, 100 shown here

  1. pmc The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    Hilary A Kenny
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1367-79. 2008
    ..These findings indicate that MMP-2 expressed by metastatic OvCa cells functionally regulates their attachment to peritoneal surfaces...
  2. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
    ..This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology...
  3. pmc A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Physiol 216:405-12. 2008
    ..Taken together, our data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of MMPs, in particular MMP-2 and MMP-9, and EGFR-activated signaling...
  4. pmc Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2
    Xiaojian Ni
    Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China
    Cancer Sci 105:18-25. 2014
    ..In a previous study, we found the expression of matrix metalloproteinase 2 (MMP2) to be significantly more pronounced at metastatic bone sites than at orthotopic sites...
  5. doi Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
    Yuki Nishida
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
    Cancer Res 68:9096-104. 2008
    ..MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2...
  6. doi Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
    C X Zhou
    School of Dentistry and Oral Health and Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, Gold Coast, Queensland, Australia
    Aust Dent J 55:385-9. 2010
    ..This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases...
  7. ncbi Integrin alpha5beta1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity
    Galina Morozevich
    V N Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia
    Cell Cycle 8:2219-25. 2009
    ....
  8. ncbi The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily
    Georgina S Butler
    Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, Center for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:15615-20. 2004
    ..These results challenge the dogma that this methionine residue and the Met-turn, which are absolutely conserved in all of the subfamilies of the metzincins, play an essential role in catalysis or active site structure...
  9. doi Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population
    Hao Li
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, PR China
    Cerebrovasc Dis 30:618-25. 2010
    ..The study was designed to examine the association of single nucleotide polymorphisms in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) genes with MMD occurrence...
  10. ncbi The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer
    Pornchai O-Charoenrat
    Department of Head and Neck Surgery, Faculty of Medicine, Siriraj Hospital Medical School, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand
    Oral Oncol 42:257-67. 2006
    ..These findings suggest that the genetic polymorphisms in the promoters of MMP2 and TIMP2 may be associated with the development and aggressiveness of HNSCC...
  11. ncbi Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from co
    Takashi Oshima
    Gastroenterological Center, Yokohama City University Medical Center, Kanagawa ken 232 0024, Japan
    Oncol Rep 19:1285-91. 2008
    ..There were positive correlations among the gene expression levels of MMP-2, MMP-9 and RECK. MMP-2 gene expression was considered a useful predictor of liver metastasis from colorectal cancer...
  12. ncbi Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts
    Kyoshi Hanata
    Department of Otolaryngology, Akita University School of Medicine, Akita, Japan
    Arch Histol Cytol 70:267-77. 2007
    ..We postulate that soluble EMMPRIN probably triggers the promotion of cancer invasion in vivo...
  13. ncbi Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism
    Sara Monea
    Department of Surgery, S A Localio Laboratory for General Surgery Research, New York, New York, USA
    J Cell Physiol 192:160-70. 2002
    ..Thus, plasmin can activate proMMP-2 only in the presence of MT1-MMP; however, this process does not require the catalytic activity of MT1-MMP...
  14. ncbi Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer
    Nils Elander
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping, Sweden
    Anticancer Res 26:791-5. 2006
    ..Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC)...
  15. ncbi Angiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cells
    Wei Huang
    Department of Gastroenterology, Ruijin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Dig Dis Sci 53:163-8. 2008
    ..These results suggest that AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP2 and MMP9...
  16. doi Single-nucleotide polymorphisms in the promoter region of matrix metalloproteinase-1, -2, and -3 in Japanese with high myopia
    Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto Unviersity Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:4432-6. 2010
    ..The purpose of this study was to determine whether functional single-nucleotide polymorphisms (SNPs) in the MMP1, -2, and -3 promoter regions are associated with high myopia in the Japanese...
  17. doi Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin α(v)β(3) interaction
    Mansi Prakash
    School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Cell Signal 23:1563-77. 2011
    ..The treatment of curcumin, the anticancer drug along with HABP1, inhibited the migration, expression of MT1-MMP and activation of MMP-2 and finally tumor growth supports the involvement of HABP1 in tumor formation...
  18. pmc Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration
    Marianne Pons
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Am J Pathol 178:2665-81. 2011
    ..A better understanding of the molecular events by which Ang II induces ECM dysregulation is of critical importance to further define its contribution to the progression of sub-RPE deposits in AMD patients with HTN...
  19. doi Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells
    Antonia Patruno
    Department of Drug Sciences, University G D Annunzio, Chieti, Italy
    J Cell Physiol 227:2767-74. 2012
    ..These results may suggest a pathway connecting an imbalance of MMPs and their cognate inhibitor TIMP-1...
  20. doi Effect on the expression of MMP-2, MT-MMP in laryngeal carcinoma Hep-2 cell line by antisense glucose transporter-1
    Ying Ying Xu
    Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Arch Med Res 43:395-401. 2012
    ..We hypothesized that Glut-1 regulates the expression of membrane type 1-MMP (MT1-MMP) and matrix metalloproteinase-2 (MMP-2)...
  21. ncbi Expression of matrix metalloproteinases (MMP-2 and -9) and their inhibitors (TIMP-1 and -2) in prostate cancer tissue
    B Brehmer
    Clinic of Urology, University Clinic Aachen, Germany
    Prostate Cancer Prostatic Dis 6:217-22. 2003
    ..The observed imbalance of MMP and TIMP is mainly caused by a loss of TIMP-1. Furthermore, palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours...
  22. doi Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis
    Hui Yan Sun
    Department of Physiology and Pathophysiology, Medical College of Chinese People s Armed Police Forces, Tianjin 300162, China
    Biochem Biophys Res Commun 395:361-6. 2010
    ..These results elucidate the important role that ZNF580 plays in the process of migration and proliferation of endothelial cells, which provides a foundation for a novel approach to regulate angiogenesis...
  23. pmc PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways
    Yong Luo
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Biochemistry 48:1838-46. 2009
    ..Accordingly, increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion...
  24. pmc Epigenetic control of the invasion-promoting MT1-MMP/MMP-2/TIMP-2 axis in cancer cells
    Andrei V Chernov
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Biol Chem 284:12727-34. 2009
    ..Our results suggest that the epigenetic control plays an important role in both the balanced regulation of the MT1-MMP/MMP-2/TIMP-2 axis and the invasive behavior in cancer cells...
  25. pmc Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma
    Mumtaz V Rojiani
    Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA
    Int J Clin Exp Pathol 3:775-81. 2010
    ..The relationship between MMP-2 expression and angiogenesis has been previously reported and its biological and therapeutic implications remain the focus of investigations...
  26. ncbi Activated matrix metalloproteinase-2--a potential marker of prognosis for epithelial ovarian cancer
    Xiaohua Wu
    Department of Obstetrics and Gynecology, Fourth Affilaited Hospital, Hebei Medical University, Shijiazhuang, Hebei, 050011, People s Republic of China
    Gynecol Oncol 84:126-34. 2002
    ..The difference was not statistically significant (P = 0.54). The positive and negative predictive values of active MMP-2 for disease progression were 65 (19/29) and 75% (9/12), respectively, and the accuracy was 68% (28/41)...
  27. ncbi Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin
    Dallas P Veitch
    Program in Epithelial Biology, Stanford University, 269 Campus Drive, Stanford, CA 94305, USA
    J Biol Chem 278:15661-8. 2003
    ..In addition, mTLD/BMP-1 null mice were shown to have deficient laminin-5 processing. Together, these data identify laminin-5 as a substrate for mTLD, suggesting a role for laminin-5 processing by mTLD in the skin...
  28. ncbi Ets-1 is up-regulated together with its target gene products matrix metalloproteinase-2 and matrix metalloproteinase-9 in atypical and anaplastic meningiomas
    A F Okuducu
    Institute of Neuropathology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Histopathology 48:836-45. 2006
    ..The aim of this study was to determine the relationship between the expression of Ets-1, MMP-2 and -9 and the malignant potential of meningiomas...
  29. ncbi Specific changes in plasma concentrations of matrix metalloproteinase-2 and -9, TIMP-1 and TGF-beta1 in patients with distinct types of primary glomerulonephritis
    Brigitte Bauvois
    INSERM 507, CNRS UMR 7131, Hopital Necker, Paris, France
    Nephrol Dial Transplant 22:1115-22. 2007
    ..There is little information on the circulating levels of these proteins in human GNs. Here, we assessed whether different histopathological GN types could be associated with distinct plasma patterns of MMPs and regulatory proteins...
  30. doi The role of matrix metalloproteinase 2 on the survival of patients with non-small cell lung cancer: a systematic review with meta-analysis
    Qian Qian
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China
    Cancer Invest 28:661-9. 2010
    ..08 (95% CI: 1.24-3.48)). This study supported the fact that MMP-2 could be included in further prospective trials studying prognostic factors in NSCLC...
  31. ncbi Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation
    Sun Ryung Lee
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 24:720-7. 2004
    ..The results suggest that MMP-9 and MMP-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling...
  32. doi A common matrix metalloproteinase (MMP)-2 polymorphism affects plasma MMP-2 levels in subjects environmentally exposed to mercury
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Sci Total Environ 409:4242-6. 2011
    ..These findings suggest a significant interaction between the C(-1306)T polymorphism and Hg exposure, possibly increasing the risk of developing diseases in subjects with the C allele...
  33. pmc RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells
    Christopher S Gondi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Int J Oncol 35:851-9. 2009
    ..In summary, it is evident from our results that MMP-2 downregulation induces caspase-8 and AIF-mediated apoptosis and, as such, shows potential for glioma therapy...
  34. ncbi Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung cancer
    Chunyuan Yu
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Cancer Res 62:6430-3. 2002
    ..55, 95% CI 3.34-9.22). These results demonstrate a significant association between the MMP2 -1306C/T polymorphism and risk of developing lung cancer solely or in a manner of interaction with carcinogen exposure...
  35. ncbi Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer
    N Inagaki
    Reproductive Biology Unit, The Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Hum Reprod 18:608-15. 2003
    ..This question was addressed by measuring cytokine concentrations and matrix metalloproteinase activities in fluid derived from uterine irrigation of such patients...
  36. ncbi Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer
    Chunyuan Yu
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cancer Res 64:7622-8. 2004
    ..34; 95% CI = 1.16-9.63). These findings suggest that the C(-1306)-C(-735) haplotype in the MMP-2 promoter contributes to risk of the occurrence and metastasis of esophageal squamous cell carcinoma by increasing expression of MMP-2...
  37. ncbi Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility
    Yifeng Zhou
    Department of Etiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Carcinogenesis 26:1117-21. 2005
    ..001). These results are consistent with our previous findings and further support the hypothesis that gain-of-function of MMP2 resulting from genetic polymorphisms plays an important role in human carcinogenesis...
  38. ncbi Matrix metalloproteinases in rectal mucosa, tumour and plasma: response after preoperative irradiation
    Eva Angenete
    Department of Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, Gothenburg, Sweden
    Int J Colorectal Dis 22:667-74. 2007
    ..The aim of this study was to investigate tissue remodeling after preoperative radiotherapy and to explore possible correlations with clinical outcome...
  39. ncbi Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation
    Meltem Sariahmetoglu
    Department of Pediatrics, 462 Heritage Medical Research Center, University of Alberta, Edmonton, AB T6G 2S2, Canada
    FASEB J 21:2486-95. 2007
    ..We conclude that MMP-2 is modulated by phosphorylation on multiple sites and that protein kinase C may be a regulator of this protease in vivo...
  40. doi Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry
    Dominique Trudel
    Department of Pathology, Centre Hospitalier Universitaire de Québec CHUQ and Université Laval, Quebec, Canada G1K 7P4
    Hum Pathol 39:731-9. 2008
    ..0001). This study suggests that MMP14 is involved mostly in Pca implantation and that MMP2 and TIMP2 expression by reactive stromal cells might be used as predictors of DFS in T3N0-2M0 Pca...
  41. ncbi Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
    ....
  42. ncbi [Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas]
    Wei Wu
    Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:908-9. 2008
    ..To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas...
  43. pmc Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells
    Po Shun Lee
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 42:227-34. 2010
    ....
  44. ncbi Expression of COX-2, MMP-2 and VEGF in stage II and III colorectal cancer and the clinical significance
    Zhi Heng Peng
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China
    Hepatogastroenterology 58:369-76. 2011
    ..To investigate the expression of COX-2, MMP-2 and VEGF in colorectal cancer and the clinical/pathological significance...
  45. pmc Circulating matrix metalloproteinase-2 and -9 enzyme activities in the children with ventricular septal defect
    Kun Shan Cheng
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
    Int J Biol Sci 9:557-63. 2013
    ..In conclusion, a positive trend between the severity of VSD and activities of MMP-2 and MMP-9 was found. Our data imply that MMP-2 and MMP-9 activities may play a role in the pathogenesis of VSD...
  46. ncbi Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinase
    I Kazes
    INSERM U 489, Hopital Tenon, Paris, France
    Kidney Int 54:1976-84. 1998
    ..In spite of evidence for the synthesis of MT1-MMP shown by immunoblotting, immunocytochemistry and RT-PCR, and of TIMP2, MMP2 was found exclusively in a latent form in human mesangial cells (HMC) serum-free culture medium...
  47. pmc Eosinophil inflammation of nasal polyp tissue: relationships with matrix metalloproteinases, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta1
    Young Mok Lee
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    J Korean Med Sci 18:97-102. 2003
    ..Close correlations were noted between TGF-beta1, and MMP-9 and MMP-2, but not with TIMP-1. MMP-2, MMP-9, and TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue...
  48. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  49. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer
    Enping Xu
    Department of Pathology and Pathophysiology, Center for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Biochem Biophys Res Commun 324:999-1003. 2004
    ..Our data suggest that MMP-2 -1306 C-->T polymorphism may be associated with colorectal cancer development and invasion in the Chinese population...
  50. ncbi The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells
    Eun Ok Lee
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul 158 710, Korea
    J Biol Chem 280:7845-53. 2005
    ..Collectively, these data suggest that Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression...
  51. doi Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF
    S Gremlich
    Department of Gynecology and Obstetrics, CHUV Hospital Maternity, Avenue Pierre Decker 2, 1011 Lausanne, Switzerland
    Hum Reprod 23:1200-6. 2008
    ..We analysed the maternal genetic profile at these polymorphic sites in IVF patients, to determine possible correlations with IVF outcome...
  52. doi Assessment of matrix metalloproteinase (MMP)-2, MMP-8, MMP-9, and their inhibitors, the tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in obese children and adolescents
    Vanessa A Belo
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970 Campinas, SP, Brazil
    Clin Biochem 42:984-90. 2009
    ....
  53. pmc ProMMP-2: TIMP-1 complexes identified in plasma of healthy individuals
    Stanley Zucker
    Department of Research, Veterans Affairs Medical Center, Northport, New York 11768, USA
    Connect Tissue Res 50:223-31. 2009
    ..In contrast to our immunoassay and bead-binding experiments, proMMP-2 failed to bind to immobilized TIMP-1 employing surface plasmon resonance technology. Additional studies are needed to clarify these contrasting results...
  54. doi Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases
    Bon Hun Koo
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 134 Sinchon Dong Seodaemun Gu, Seoul 120 749, South Korea
    FEBS J 276:6271-84. 2009
    ..Thus, our experimental data, taken together with the broad expression of proprotein convertases, suggest that the proprotein convertase-mediated processing may be a general activation mechanism for pro-matrix metalloprotease-2 in vivo...
  55. ncbi Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma
    Benicio L B B P Nunes
    Coloproctology Service, Hospital Santa Casa de Misericórdia de Maceió, Alagoas, Brazil
    Int J Biol Markers 24:156-64. 2009
    ..The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors...
  56. doi mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: potential role of TIMP1 as an adverse prognostic factor
    Carlos Alberto Scrideli
    Department of Pediatrics, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Leuk Res 34:32-7. 2010
    ..04) and multivariable analysis (P=0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL...
  57. doi Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147
    Yangqiong Ou
    Laboratory of Immunopharmacology, Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191 Beijing, People s Republic of China
    Rheumatol Int 31:1479-85. 2011
    ..01). Our results point to a possible mechanism of SIN on treatment of RA is the inhibitory effect of SIN on cell invasion and migration ability, which strongly correlates with repressing the expression of CD147, MMP-2, and MMP-9...
  58. ncbi Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer
    Mohammad A Mohammad
    Biochemistry and Molecular Biology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Int J Biol Markers 25:69-74. 2010
    ..To analyze the behavior of matrix metalloproteinases (MMPs) in their active state in patients with bladder cancer...
  59. pmc The role of hypoxia inducible factor-1α in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles
    Rong Wan
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky, USA
    Nanotoxicology 5:568-82. 2011
    ..Our results suggest that HIF-1α accumulation may be involved in the increased MMP-2 and MMP-9 production in U937 cells exposed to Nano-Ni...
  60. pmc Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines
    Rihua Zhang
    Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e23831. 2011
    ..This study investigates the effect of the SDF-1α/CXCR4 axis on expression and activity of MMP-2 induced by osteopontin...
  61. doi Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells
    Su Ju Tsai
    Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan
    Biochem Biophys Res Commun 425:462-7. 2012
    ..This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis...
  62. ncbi Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer
    Jerome Rollin
    INSERM, U618, Tours F 37000, France
    Lung Cancer 56:273-80. 2007
    ..6-fold in -735CC patients (p=0.045; 95% CI=1.0-6.7). The results of this study suggest that the -735C/T MMP-2 polymorphism might be an independent prognostic marker in NSCLC, but this should be confirmed in a larger cohort of patients...
  63. ncbi Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement
    Aiko Suminoe
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Leuk Res 31:1437-40. 2007
    ..005 and 0.009) and between CNS involvement and the MMP-2/TIMP-2 ratio (p=0.012). The results suggest that MMP/TIMP balance is closely related to the infiltration of leukemia cells into extramedullary organs...
  64. ncbi Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness
    Sigrid Harendza
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg D 20246, Germany
    J Biol Chem 278:20490-9. 2003
    ....
  65. ncbi Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes
    Yifeng Zhou
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 25:399-404. 2004
    ..These findings suggest that the presence of the variant allele in the promoter of MMP2 or TIMP2 may be a protective factor for the development of breast cancer...
  66. pmc Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma
    Ze Yu Wu
    Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, Guangdong Province, China
    World J Gastroenterol 12:2941-4. 2006
    ..To examine matrix metalloproteinase-2 (MMP-2) expression in gastric cancer tissues and to evaluate its relationship with lymph node micrometastasis...
  67. pmc Active MMP-2 effectively identifies the presence of colorectal cancer
    Mary Jo Murnane
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Int J Cancer 125:2893-902. 2009
    ....
  68. ncbi Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
    G Angus McQuibban
    Department of Biochemistry and Molecular Biology and the Biomedical Research Centre, University of British Columbia, Vancouver, Canada
    Blood 100:1160-7. 2002
    ..We propose that MMPs have an important role in modulating inflammatory and immune responses by processing chemokines in wound healing and in disease...
  69. pmc Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
    Brian C McKaig
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Pathol 162:1355-60. 2003
    ..These studies illustrate a potential mechanism by which differential expression of isoforms of TGF-beta may lead to excessive deposition of extracellular matrix and stricture formation via TIMP-1-mediated inhibition of MMP activity...
  70. ncbi Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands
    Breast Cancer Res Treat 88:197-204. 2004
    ..06). These findings suggest that breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes...
  71. ncbi Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor
    Myung Jin Park
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Gu, Seoul 139 706, Korea
    J Biol Chem 282:30485-96. 2007
    ..Our data collectively suggest that NGF stimulates endothelial cell invasion and cord formation by augmenting MMP-2 via the PI3K/Akt signaling pathway and AP-2 transcription factor, which may be responsible for triggering angiogenesis...
  72. ncbi Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed
    E Morgunova
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Science 284:1667-70. 1999
    ..The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability...
  73. ncbi Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms
    J Caird
    Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur J Neurol 13:1098-105. 2006
    Matrix metalloproteinases 2 and 9 (MMP 2 and -9) have been implicated in the pathogenesis of atherosclerosis and aneurysm formation...
  74. pmc A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation
    Yuichiro Hirose
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Am J Hum Genet 82:1122-9. 2008
    ..Our data indicate that regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH...
  75. doi Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects
    Peter McColgan
    Imperial College Cerebrovascular Research Unit, Imperial College London, Hammersmith Hospitals, London, United Kingdom
    Int J Cancer 125:1473-8. 2009
    ..Subjects with the MMP-1 nt-1607 polymorphism have an increased association with colorectal cancer. Those homozygous for either the MMP-2/1306T or 735T allele may be at reduced risk of lung cancer, although the evidence base is small...
  76. doi Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma
    Jesus Planaguma
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, FI 00014 University of Helsinki, Helsinki, Finland
    Hum Pathol 42:57-67. 2011
    ..These results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several of the basement membrane components, which are likely to associate with the invasive stage of EEC and OEC...
  77. doi Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients
    Irena Ranogajec
    Department of Clinical Cytology, SUNCE Polyclinic, Trnjanska cesta 108, 10000 Zagreb, Croatia
    Med Oncol 29:561-9. 2012
    ..9). Our results suggest that MMP-2, MMP-9, APN/CD13 expression and MMP-2/MMP-9 coexpression in combination with other standard prognostic factors can serve as a poor prognostic factor in the evaluation of breast cancer prognosis...
  78. ncbi The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
    H Will
    In Vitek GmbH, Robert Roessle Strasse 10, D 13125 Berlin Buch, Federal Republic of Germany
    J Biol Chem 271:17119-23. 1996
    ..These data demonstrate the basic mechanism of MT1-MMP action on progelatinase A and the reason for the lack of inhibition by TIMP-1 previously demonstrated in cell-based activation studies...
  79. ncbi Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion
    Lisa A Di Nezza
    Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
    Cancer 94:1466-75. 2002
    ..The cellular localization of MMP-2, MMP-9, membrane type 1 (MT1)-MMP, tissue inhibitors of metalloproteinases (TIMPs) 1-3, and the presence of active gelatinases were investigated in endometrial carcinoma...
  80. ncbi Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene
    Zhendong Ma
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    J Biol Chem 279:46326-34. 2004
    ..These results illustrate the connection between the SWI/SNF complex and optimal expression of MMP-2 and highlight the critical function of Brg-1 in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter...
  81. ncbi Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease
    Nicolas Lamblin
    Centre Hospitalier Universitaire de Lille, Lille Cedex, France
    J Am Coll Cardiol 40:43-8. 2002
    ..Our hypothesis was that functional polymorphisms in matrix metalloproteinase (MMP) genes may act as susceptibility factors for the development of coronary aneurysms (CAs)...
  82. pmc A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
    Marina R Bergman
    Cardiology Section, Department of Medicine, San Francisco Veterans Affairs Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem J 369:485-96. 2003
    ..This report is the first demonstration that defined members of the Fos and Jun transcription-factor families specifically regulate this gene under conditions relevant to critical pathophysiological processes...
  83. ncbi A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma
    Xiaoping Miao
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Cancer Res 63:3987-90. 2003
    ..36-2.20) for the CC genotype. These findings are consistent with our initial observation for lung cancer and further support the hypothesis that MMP2 genotype may influence individual susceptibility to the development of certain cancer...
  84. ncbi Functional genotype in matrix metalloproteinases-2 promoter is a risk factor for oral carcinogenesis
    Shu Chun Lin
    School of Dentistry, National Yang Ming University, Taipei, Taiwan
    J Oral Pathol Med 33:405-9. 2004
    ..This study aimed to assess the association of such genotype with the risk of OSCC and oral submucous fibrosis (OSF), which is a precancerous condition that exhibits excessive collagen production and etiologically links to areca use...
  85. ncbi Genetic variations in the human gelatinase A (matrix metalloproteinase-2) promoter are not associated with susceptibility to, and severity of, chronic periodontitis
    Lydie Izakovicova Holla
    Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenskeho nam 2, 662 43 Brno, Czech Republic
    J Periodontol 76:1056-60. 2005
    ..In this study, we test the hypothesis that variations in this gene influence the development and severity of chronic periodontitis...
  86. pmc Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective
    Richard A Dean
    University of British Columbia, Centre for Blood Research, 4 401 Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Mol Cell Biol 27:8454-65. 2007
    ..Hence the unmasking of cytokines, such as VEGF, by metalloproteinase processing of their binding proteins is a new mechanism in the control of cytokine activation and angiogenesis...
  87. ncbi Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin
    C M Overall
    Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 274:4421-9. 1999
    ..This location implies that considerable molecular movement of the TIMP-2. C domain complex would be needed for the bound TIMP-2 to inhibit in cis the gelatinase A active site...
  88. ncbi Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix
    Denis Stygar
    Division for Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, 17176 Stockholm, Sweden
    Biol Reprod 67:889-94. 2002
    ..These data indicate the involvement of MMP-2 and MMP-9 in the cervical ripening process...
  89. ncbi Diverse role of MMP-2 and MMP-9 in the clinicopathological behavior of Hodgkin's lymphoma
    Outi Kuittinen
    Department of Oncology and Radiotherapy, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland
    Eur J Haematol 69:205-12. 2002
    ..The favorable prognostic value of MMP-2 is surprising in view of the role of MMPs in solid tumors. This, however, may be linked to the basic biological differences of hematological malignancies vs. other tumors...
  90. ncbi Significance of MMP-2 expression in prostate cancer: an immunohistochemical study
    Dominique Trudel
    Departments of Pathology, Laval University, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Cancer Res 63:8511-5. 2003
    ..267; P = 0.0012). Increased MMP-2 expression by malignant prostatic epithelia is an independent predictor of decreased prostate cancer disease-free survival...
  91. ncbi Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases
    Katherine Conant
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 10:21-8. 2004
    ..These results also suggest a potential mechanism for acceleration of HIVD with methamphetamine use...
  92. ncbi The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9
    Mark R Morgan
    Tumour Biology Laboratory, Cancer Research UK Clinical Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Sq, London EC1M 6BQ, United Kingdom
    J Biol Chem 279:26533-9. 2004
    ....
  93. ncbi Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2
    A Zankl
    Division of Molecular Pediatrics, Center Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Clin Genet 67:261-6. 2005
    ..Recently, mutations in the matrix metalloproteinase 2 (MMP2) gene were identified in affected individuals with a clinical diagnosis of NAO in two Arab ..
  94. ncbi Matrix metalloproteinases participate in osteosarcoma invasion
    Kristin Bjørnland
    Institute for Surgical Research, Rikshospitalet, 0027 Oslo, Norway
    J Surg Res 127:151-6. 2005
    ..Thus, the aim of the present study was to evaluate the involvement of MMPs in a panel of human OS cell lines, xenografts and biopsies...
  95. ncbi Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma
    Zi Bin Gao
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Int J Mol Med 16:599-603. 2005
    The aim of this study is to investigate the expression of matrix metalloproteinase 2 (MMP-2) and the tissue inhibitor of metalloproteinase 2 (TIMP-2) in oral squamous cell carcinoma (OSCC) and adjacent normal tissues, and explore the role ..
  96. ncbi Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease
    Horng Rong Chang
    Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Clin Chim Acta 366:243-8. 2006
    ..However, the relationship of circulating levels of MMP-2, -9 and serum creatinine in the patients of chronic kidney disease (CKD) has not yet been investigated...
  97. ncbi Induction of secreted matrix metalloproteinase-9 activity in human melanoma cells by extracellular matrix proteins and cytokines
    Yiqun G Shellman
    Department of Dermatology, University of Colorado Health Science Center at Fitzsimons, Aurora, CO 80045, USA
    Melanoma Res 16:207-11. 2006
    ....
  98. ncbi Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta
    P Petignat
    Department of Obstetrics and Gynecology, Hormone Laboratory, University of Geneva, Switzerland
    Int J Gynecol Cancer 16:1679-84. 2006
    ..MMP-2 and mutp53 are overexpressed in HM as compared with normal trophoblast and might participate in the invasive behavior of the HM...
  99. pmc Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
    F J G M Kubben
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Cancer 95:744-51. 2006
    ..We conclude that MMP-related SNPs, especially MMP-7(-181A>G) and TIMP-2(303C>T), may be helpful in identifying gastric cancer patients with a poor clinical outcome...
  100. ncbi Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer
    Chun Ying Wu
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Cancer 43:799-808. 2007
    ..We aim to elucidate the role of MMP-2 and TIMP-2 in clinicopathological manifestations of gastric cancer...
  101. ncbi Evidence implicating matrix metalloproteinases in the mechanism underlying accumulation of IL-1beta and neuronal apoptosis in the neocortex of HIV/gp120-exposed rats
    Rossella Russo
    Department of Pharmacobiology, University of Calabria, Via P Bucci, 87036 Arcavacata di Rende CS, Italy
    Int Rev Neurobiol 82:407-21. 2007
    ....

Research Grants67

  1. Comparative Evaluation of Urinary Biological Markers for the Prognostic Stratific
    Bertrand Jaber; Fiscal Year: 2009
    ..relevant urinary markers include Kidney Injury Molecule-1 (KIM-1) (a tubular dedifferentiation marker), Neutrophil Gelatinase-Associated Lipocalin (NGAL) (a tubular proliferation marker), interleukin-18 (IL-18) (a mediator of ..
  2. Linda L Phillips; Fiscal Year: 2016
    ..These studies are likely to identify novel options for regional and fiber targeted therapy in patients suffering from axonal damage after TBI. ..
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..2) Improved renal function, reflected by the concentration of urinary Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)...
  4. Matam Vijay Kumar; Fiscal Year: 2015
    ..with colitis, the multifaceted biologic activity of Lcn2 (as well as that of its human ortholog, Neutrophil Gelatinase-Associated Lipocalin) or NGAL suggests it may play a central role in IBD...
  5. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..processed and frozen for later blinded, batched measurement of biomarkers such as interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin C...
  6. MARK EDWARD WESTERMAN; Fiscal Year: 2014
    ..In contrast to established biomarkers of AKI, plasma creatinine (pCr) and neutrophil gelatinase-associated lipocalin (NGAL), in both these studies urinary hepcidin (uHep;ng/ml) and uHep adjusted for ..
  7. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..analyze urine for the following potential biomarkers of AKI: kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), glutathione-S-transferases (alpha and pi-..
  8. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
    ..We will also detect subclinical renal injury using the validated urinary biomarkers: neutrophil gelatinase-associated lipocalin and kidney injury marker 1...
  9. "Validation of Novel CKD Biomarkers in CRIC"
    Kathleen D Liu; Fiscal Year: 2013
    ....
  10. Subclinical and clinical heart disease and the effect on kidney injury and diseas
    Meyeon Park; Fiscal Year: 2013
    ..Use of novel urinary biomarkers such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may allow differentiation between different etiologies of rise in creatinine ..
  11. NGAL: A novel early biomarker of acute renal injury
    Prasad Devarajan; Fiscal Year: 2005
    ..We have recently identified Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a protein that is markedly induced in kidney tubule cells very early after ..
  12. Urinary Biomarkers for Acute Kidney Injury in Critical Illness
    Steven Coca; Fiscal Year: 2007
    ..Urinary IL-18, neutrophil gelatinase- associated lipocalin (NGAL), and cystatin C are three promising biomarkers for the early detection and ..
  13. CSILLA LIPPERT; Fiscal Year: 2015
    ..We hypothesize that ACPP-based delivery of these therapies will increase their therapeutic index. The application of ACPPs to mouse models of asthma will improve our understanding, evaluation, and treatment of asthma. ..
  14. David H Lovett; Fiscal Year: 2014
    ..Our work suggests that a new molecule contributes to heart injury and offers the possibility of new forms of therapy for this common and disabling disorder. ..
  15. Ana J Coito; Fiscal Year: 2014
    ....
  16. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..apoptosis, necrosis, peroxynitrite and poly(ADP- ribose) formation, and serum concentrations of neutrophil gelatinase-associated lipocalin...
  17. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2010
    ..Moreover, we will assess the function of Timp-1 overexpression as a therapeutic approach in partial liver IRI and in steatotic OLT. ..
  18. Driss Zoukhri; Fiscal Year: 2015
    ..abstract_text> ..
  19. ANDREA W PAGE-MCCAW; Fiscal Year: 2015
    ..To accomplish these aims we have garnered support from a broad team of experts to inform and guide our experiments. ..
  20. Jihe Zhao; Fiscal Year: 2014
    ..Completion of this project will shed new lights on mechanisms responsible for breast cancer metastasis which may leads to new therapeutic intervention. ..
  21. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  22. Zena Werb; Fiscal Year: 2016
    ..mechanisms of this complex interplay between malignant cancer cells and the surrounding non- malignant stroma represents one of the major challenges in cancer research, which once understood, will foster new approaches to cancer therapy, ..
  23. Characterization of the interaction between Mmp2 Frac and during axon guidance
    CRYSTAL MARIE MILLER; Fiscal Year: 2010
    ....
  24. Mechanisms of MMP-2 transcription in hindlimb ischemia
    Rajabrata Sarkar; Fiscal Year: 2010
    ..b>Matrix metalloproteinase 2 (MMP-2) is transcriptionally induced in tissue ischemia and is a critical enzyme for angiogenesis and ..
  25. PROPERTIES OF OLFACTORY RECEPTORS - NEURAL REGENERATION
    RICHARD COSTANZO; Fiscal Year: 2009
    ..abstract_text> ..
  26. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..e. neutrophil gelatinase associated lipocalin, transferrin, ceruloplasmin, al-acid glycoprotein, chemokine ligand 2, adiponectin, ..
  27. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2013
    ..antibodies binding to MC (-actinin directly modulated inflammatory gene expression including cytokines and neutrophil gelatinase associated lipocalin (NGAL, lipocalin-2), via Fc-dependent and independent mechanisms...
  28. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..We have recently identified the presence of NGAL (Neutrophil Gelatinase- Associated Lipocalin) both alone, and complexed to the gelatinase MMP-9, in the urine of women with ..
  29. Marxa L Figueiredo; Fiscal Year: 2014
    ....
  30. Sanjay Misra; Fiscal Year: 2016
    ..The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy. ..
  31. Role of C/EBPepsilon in myeloid differentiation
    Stephanie Halene; Fiscal Year: 2010
    ..secondary granule proteins (SGP) lactoferrin (LF), transcobalamin I (TCI), neutrophil collagenase (NC) and neutrophil gelatinase (NG) marks the commitment to terminal neutrophil differentiation...
  32. Early diagnosis of acute kidney injury by aptasensors
    Muslum Ilgu; Fiscal Year: 2013
    ..our proposal lies in the combination of aptamer technology with microcantilever detection of serum/urine neutrophil gelatinase-associated lipocalin (NGAL), an early marker of AKI [2-4 hours at the onset of AKI with cutoff ..
  33. Shuta Ishibe; Fiscal Year: 2016
    ..Finally, to address FAK's role in its regulation of downstream signaling molecules such as inducing matrix metalloproteinase 2 (MMP-2) activity, mice as well as cell culture models defined in the first two specific aims will be ..
  34. Mechanistic Studies of MUC4 and NGAL in Pancreatic Adenocarcinoma
    MICHAEL JAMES BAINE; Fiscal Year: 2012
    ..in tissue microarrays containing well characterized tumors tissues, we observed elevated expression of neutrophil gelatinase associated lipocalin (NGAL), also known as Lipocalin 2 or uterocalin, during pancreatic cancer progression...
  35. W Ray Kim; Fiscal Year: 2015
    ..of ATN in ESLD patients, based on our preliminary data that urinary biomarkers such as 1- microglobulin, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and microalbumin correlate with renal histology, ..
  36. Intercalated Cells of the Distal Nephron Defend the Urinary System
    Neal Paragas; Fiscal Year: 2013
    ..believe that the uroepithelia of the distal tubule detects and secretes a bacteriostatic molecule called neutrophil gelatinase-associated lipocalin (NGAL)...
  37. RONALD MARK PAYNE; Fiscal Year: 2015
    ..Our research team identified neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic biomarker and showed that plasma and urine NGAL levels 2 hours ..
  38. Neutrophil gelatinase-associated lipocalin mediated retinoid effects in the skin
    KIMBERLY R LUMSDEN; Fiscal Year: 2010
    ..This research will help to characterize neutrophil-gelatinase associated lipocalin's (NGAL) effect on the skin and will hopefully lead to the discovery of therapies alternative to 13-cis RA, which is known to cause birth defects. ..
  39. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ....
  40. STRUCTURAL STUDIES OF RECEPTORS IN MUCUOSAL IMMUNITY
    Roland Strong; Fiscal Year: 2000
    ..mount immune responses in the mucosal compartment by: 1) determining the three-dimensional structure of Neutrophil Gelatinase Associated Lipocalin; 2) characterizing the interaction between the Polymeric Immunoglobulin Receptor and ..
  41. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2006
    ..analyze urine for the following potential biomarkers of AKI: kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), glutathione-S-transferases (alpha and pi-..
  42. Gadiparthi N Rao; Fiscal Year: 2015
    ....
  43. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..The success of the proposed experiments may lead to a significant advancement in the development of EGCG as a potentially safe and inexpensive treatment option for RA. ..
  44. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ....
  45. William P Fay; Fiscal Year: 2016
    ..We anticipate that the information gained from our experiments will lead to new strategies to treat and prevent vein graft disease. ..
  46. Urokinase plasminogen activator receptor associated protein and acute lung injury
    Michael Bundesmann; Fiscal Year: 2010
    ..It will help us understand how the lung coordinates several components of the repair process. ..
  47. Inflammatory Breast Cancer: Factors Contributing to Dissemination
    Bonnie F Sloane; Fiscal Year: 2012
    ..This research will be done primarily in Egypt at Cairo University in collaboration with Mona Mostafa Mohamed, as an extension of NIH Grant No. R01CA131990, 8-01-2008 to 5-31-2013.
  48. Laura F Gibson; Fiscal Year: 2014
    ....
  49. Aging related susceptibility to lung injury - remodeling and oxidative stress
    Jesse Roman; Fiscal Year: 2012
    ....
  50. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
    ....
  51. MT1-MMP-based Animal Model of Age-related Macular Degeneration (AMD)
    George Inana; Fiscal Year: 2010
    ....
  52. CXCR4 regulation of tumor progression in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2012
    ..Targeting this process by mobilizing myeloma cells out of the marrow will lead to a higher sensitivity to killing of the cells with cytotoxic agents. ..
  53. Fucosyl transferases in inflammation and angiogenesis
    Alisa E Koch; Fiscal Year: 2013
    ..These studies should form the basis for us to investigate the role of futs in human RA in the future as well as potentially open up an entirely new family of targets for the treatment of RA. ..
  54. PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURY
    Michael Robbins; Fiscal Year: 2004
    ..These studies offer the promise of developing rational therapeutic strategies directed at reducing the severity of this dose-limiting morbidity in human beings. ..
  55. Andrew P Goodwin; Fiscal Year: 2014
    ..With his substantial ability and ambition combined with outstanding mentors and institutional support, Dr. Goodwin is a prime candidate to excel in the independent development of innovative cancer nanotechnologies. ..
  56. Ming Hui Zou; Fiscal Year: 2016
    ..increased elastin degradation, enlargement of the aorta, abnormal expression and activation of matrix metalloproteinase 2 (MMP2), and an increased incidence of AAA in ApoE knockout (ApoE-/-) mice...
  57. SDF-1 and neurogenesis in HIV-1 associated dementia
    JIALIN CHARLES ZHENG; Fiscal Year: 2012
    ..This work will elucidate mechanisms through which neurogenesis is affected by HAD, which could identify new therapeutic strategies for treating HAD and other neurodegenerative disorders. ..
  58. Alice S Chen-Plotkin; Fiscal Year: 2016
    ....
  59. Correlation of MMP activity with anatomic changes in the ruptured AAA wall
    SEAN JASON ENGLISH; Fiscal Year: 2011
    ..This study will allow for the development of non-invasive, imaging techniques that can be used to determine when AAAs are prone to rupture or dissection before emergency surgery must be performed. ..
  60. Shaw in Jamaica MoN Project
    TASHNI ANN DUBROY; Fiscal Year: 2013
    ..collaborate with investigators at two universities in Kingston, Jamaica, the University of the West Indies (UWI), Mona Campus and the University of Technology (Utech)...
  61. Dirk Bohmann; Fiscal Year: 2014
    ..The potential tumor suppressive function of a specific inhibitor of FGF signaling, which is generated by MMP, will be tested. ..
  62. Signaling Through Membrane Type 1 Matrix Metalloproteinase
    William Scheerer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Variation in Severity of Sickle Cell Disease among the Yorubas
    RICHARD STANLEY COOPER; Fiscal Year: 2013
    ..investigators at the University College Hospital (UCH), Ibadan, Nigeria, the University of the West Indies (UWI), Mona, Kingston, Jamaica, and Loyola Medical School, Chicago, USA to study genes which modify severity and clinical ..
  64. Combination therapy to inhibit glioma growth by Ad MMP2 and radiation
    Jasti S Rao; Fiscal Year: 2012
    ..This proposal represents a combinational therapeutic approach using p-MMP-2 siRNA. This strategy may improve radiotherapy outcomes for the treatment of glioblastomas. ..
  65. Developmental Pesticide Exposure: The Parkinson's Disease Phenotype
    Mona Thiruchelvam; Fiscal Year: 2010
    PrincipalInvestigator/Program Director (Last, First, Middle): Thiruchelvam, Mona J...
  66. The Role of the Microenvironment in Early Ovarian Cancer Metastasis
    HILARY ANN KENNY; Fiscal Year: 2010
    ....
  67. NMR Studies of Plasminogen and Related Genomic Domains
    Miguel Llinas; Fiscal Year: 2004
    ..Implicated in tissue remodeling is the matrix metalloproteinase 2, which digests denatured collagen (gelatin) via adhesion through three fibronectin type II domains...