MMP-1

Summary

Gene Symbol: MMP-1
Description: matrix metallopeptidase 1
Alias: CLG, CLGN, interstitial collagenase, fibroblast collagenase, matrix metallopeptidase 1 (interstitial collagenase), matrix metalloprotease 1, matrix metalloproteinase 1
Species: human

Top Publications

  1. doi KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition
    Fang Cheng
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Cell Host Microbe 10:577-90. 2011
  2. ncbi Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer
    Yuji Hinoda
    Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Int J Cancer 102:526-9. 2002
  3. ncbi Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases
    Katherine Conant
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 10:21-8. 2004
  4. ncbi Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK
    Sabine Krueger
    Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    J Biol Chem 281:2868-75. 2006
  5. ncbi Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 67:11621-9. 2007
  6. doi Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts
    I A Lian
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Olav Kyrres gate 11, Trondheim, Norway
    Placenta 31:615-20. 2010
  7. pmc MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms
    Muna Affara
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 12:43. 2011
  8. doi A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer
    Li Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Cancer 117:5172-81. 2011
  9. ncbi Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke
    Becky A Mercer
    Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:17690-6. 2004
  10. ncbi Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma
    Tomoko Hashimoto
    Department of Otolaryngology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    Cancer Lett 211:19-24. 2004

Research Grants

  1. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
  2. Suresh C Tyagi; Fiscal Year: 2016
  3. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
  4. Suresh C Tyagi; Fiscal Year: 2015
  5. Apoptosis and Fibrosis
    ARIEL R JOHNSON; Fiscal Year: 2013
  6. Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung Transplant
    Meera Subramaniam; Fiscal Year: 2010
  7. ANDREA W PAGE-MCCAW; Fiscal Year: 2015
  8. TGF-beta receptor signaling in scleroderma
    MARIA TROJANOWSKA TROJANOWSKA; Fiscal Year: 2012
  9. ACE Inhibition and Novel Cardiovascular Risk Factors
    Marco Pahor; Fiscal Year: 2004
  10. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010

Detail Information

Publications281 found, 100 shown here

  1. doi KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition
    Fang Cheng
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Cell Host Microbe 10:577-90. 2011
    ....
  2. ncbi Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer
    Yuji Hinoda
    Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Int J Cancer 102:526-9. 2002
    ..0010; OR = 1.949; 95% CI = 1.305-2.911). Our present data suggest that the MMP-1 and MMP-3 promoter polymorphisms may be associated with a colorectal cancer susceptibility in Japanese...
  3. ncbi Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases
    Katherine Conant
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 10:21-8. 2004
    ..These results also suggest a potential mechanism for acceleration of HIVD with methamphetamine use...
  4. ncbi Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK
    Sabine Krueger
    Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    J Biol Chem 281:2868-75. 2006
    ..Induction of MMP-1 is further implicated in complex processes induced by H. pylori, resulting in tissue degradation and remodeling of the gastric mucosa...
  5. ncbi Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 67:11621-9. 2007
    ..This model highlights the role of MT1-MMP at the leading edge of migrating cells...
  6. doi Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts
    I A Lian
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Olav Kyrres gate 11, Trondheim, Norway
    Placenta 31:615-20. 2010
    ..05). Based on these findings, we hypothesize that reduced levels of MMP1 protein in EVTs could be linked to the impaired trophoblast invasion in PE and/or FGR...
  7. pmc MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms
    Muna Affara
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 12:43. 2011
    ..b>Matrix metalloproteinase 1 (MMP1) is important in both normal development and in numerous pathologies...
  8. doi A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer
    Li Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Cancer 117:5172-81. 2011
    Matrix metalloproteinase-1 (MMP-1), an interstitial collagenase, plays an important role in the breakdown of extracellular matrix and mediates pathways of apoptosis, angiogenesis, and immunity...
  9. ncbi Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke
    Becky A Mercer
    Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:17690-6. 2004
    The interstitial collagenase matrix metalloprotein-ase-1 (MMP-1) is up-regulated in the lung during pulmonary emphysema. The mechanisms underlying this aberrant expression are poorly understood...
  10. ncbi Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma
    Tomoko Hashimoto
    Department of Otolaryngology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    Cancer Lett 211:19-24. 2004
    ..042; OR, 1.56). In the MMP-3 polymorphism, there was no significant difference in the genotype distribution between patients and controls. These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC...
  11. doi Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies
    Bo Peng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Mutagenesis 25:41-8. 2010
    ..Future studies with larger sample sizes are warranted to further evaluate these associations in more detail...
  12. doi Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population
    Shin Yup Lee
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Respiration 80:133-8. 2010
    ..Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent...
  13. ncbi Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes
    Seong Su Nah
    Division of Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    FEBS Lett 581:1928-32. 2007
    ..In conclusion, accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha...
  14. doi Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer
    Wiebke Sauter
    Institute of Epidemiology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1127-35. 2008
    ..MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens...
  15. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube 755 8505, Yamaguchi, Japan
    Int J Cancer 106:372-4. 2003
    ..Our present data suggest that the MMP-1 promoter polymorphism may be linked to susceptibility for conventional RCC...
  16. ncbi The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma
    Kinya Okamoto
    The Second Department of Internal Medicine, Tottori University School of Medicine, Yonago
    Intern Med 49:887-95. 2010
    ....
  17. doi Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
    Edyta Wieczorek
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland
    BJU Int 112:1207-14. 2013
    ....
  18. pmc Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
    M Kajita
    Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Cell Biol 153:893-904. 2001
    ..These findings revealed a novel interaction of the two molecules that have each been implicated in tumor cell migration and invasion...
  19. ncbi A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
    Shunji Matsumura
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    J Cancer Res Clin Oncol 130:259-65. 2004
    ..In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer...
  20. ncbi IL-1 receptor antagonist attenuates MAP kinase/AP-1 activation and MMP1 expression in UVA-irradiated human fibroblasts induced by culture medium from UVB-irradiated human skin keratinocytes
    Xiaoyong Wang
    Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, PR China
    Int J Mol Med 16:1117-24. 2005
    ..Collectively, our data suggest that IL-1 plays an important role in the dermal collagen degradation associated with UV-induced premature aging of the skin and IL-1Ra may be applied for the prevention and treatment of photoaging...
  21. ncbi Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer
    Nils Elander
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping, Sweden
    Anticancer Res 26:791-5. 2006
    ..Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC)...
  22. doi A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer
    Yoshinori Shimizu
    Department of Otolaryngology, School of Medicine, Kanazawa University, Takaramachi 13 1, Ishikawa, Japan
    Auris Nasus Larynx 35:381-9. 2008
    ..MMP-1 -1607 2G/2G and IL-8 -251 A/A genotypes enhance transcriptional activity and may be associated with increased risk in malignant tumors. We therefore evaluated the impact of these SNPs in tongue squamous cell carcinoma (SCC)...
  23. doi The influence of interstitial collagenase-1 genotype polymorphism on colorectal cancer risk in Iranian population
    F Kouhkan
    Genetics Division, Biology Department, Faculty of Sciences, Isfahan University, Isfahan, Iran
    Cancer Invest 26:836-42. 2008
    b>Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene...
  24. doi Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers
    Ching Yu Yen
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, Taiwan
    Biomarkers 14:244-9. 2009
    ..With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers...
  25. doi CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells
    David A Armstrong
    Research Service, Department of Veterans Affairs, White River Junction, VT 05009, USA
    Mol Cancer Res 7:1517-24. 2009
    ..These studies establish CEBPB as an important mediator of metalloproteinase gene activation during inflammatory responses in lung cancer cells and highlight the different regulatory roles of CEBPB isoforms...
  26. pmc Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proin
    Hyun Mi Choi
    East West Bone and Joint Research Institute, East West Neo Medical Center, Kyung Hee University, 149 Sangil dong, Gangdong gu, Seoul, 134 727, Republic of Korea
    Arthritis Res Ther 11:R161. 2009
    ....
  27. pmc Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2
    Michel Steenport
    Department of Pathology and Laboratory Medicine
    J Immunol 183:8119-27. 2009
    ..These data also suggest that this nexus is targetable utilizing anti-TNF-alpha therapies and/or selective EP4 antagonists...
  28. doi Single-nucleotide polymorphisms in the promoter region of matrix metalloproteinase-1, -2, and -3 in Japanese with high myopia
    Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto Unviersity Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:4432-6. 2010
    ..The purpose of this study was to determine whether functional single-nucleotide polymorphisms (SNPs) in the MMP1, -2, and -3 promoter regions are associated with high myopia in the Japanese...
  29. pmc Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study
    Stefan Lakemeier
    Department of Orthopedics and Rheumatology, University Hospital Marburg, Marburg, Germany
    BMC Musculoskelet Disord 11:271. 2010
    ..It is unclear which of these enzymes contribute to LHB but we chose to study MMP 1, 3, and 9 and hypothesized that one or more of them may be altered in LHB, whether diagnosed preoperatively or ..
  30. pmc Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway
    Paul Haines
    Boston University School of Medicine, Arthritis Center, Boston, MA USA
    J Dermatol Sci 64:210-6. 2011
    ..b>Matrix metalloproteinase 1 (MMP-1) is a collagenase capable of degrading insoluble triple helical collagens...
  31. pmc The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway
    Yuk Cheung Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 287:41032-43. 2012
    ..b>Matrix metalloproteinase 1 (MMP-1), one of the Ets-1 downstream mediators, was negatively regulated by miR-199a-5p...
  32. pmc Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma
    Astrid Lievre
    INSERM U775 et Université René Descartes, Paris, France
    BMC Cancer 6:270. 2006
    ....
  33. ncbi The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    ..MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of ..
  34. ncbi siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line
    Xiaoling Jiang
    Department of Orthopedic Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Physiol 202:723-30. 2005
    ....
  35. doi UV-induced DNA damage initiates release of MMP-1 in human skin
    Kelly K Dong
    AGI Dermatics, Freeport, New York, USA
    Exp Dermatol 17:1037-44. 2008
    ..DNA damage in the keratinocytes initiates one of the signals for MMP-1 release, and enhancing DNA repair can reduce MMP-1 expression in human skin cells and tissue...
  36. ncbi Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:1024-9. 2006
    ..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men...
  37. ncbi Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression
    Haixin Lei
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Breast Cancer Res Treat 103:61-9. 2007
    ..34, 95% CI 1.08-5.08). Although our study suggests some correlations between the studied SNPs and the progression of breast cancer, the rarity of the risk genotypes limits their usefulness in the clinic...
  38. pmc Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter
    Becky A Mercer
    Department of Medicine, Division of Molecular and Pulmonary Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 40:4-12. 2009
    ..This characterization of a smoke response region in the distal MMP-1 promoter has implications for smoking-related diseases such as cancer, heart disease, and emphysema...
  39. ncbi Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease
    Shu Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Heart J 24:1668-71. 2003
    ..In addition, we examined a polymorphism in the human MMP-3 gene that was previously reported to be associated with progression of coronary atherosclerosis...
  40. pmc MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
    Ivan O Rosas
    Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School ofMedicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 5:e93. 2008
    ..The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression...
  41. pmc Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis
    Penelope A Bradbury
    Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada
    Carcinogenesis 30:793-8. 2009
    ..MMP1, MMP3 and possibly MMP12 -82A/G polymorphisms and their haplotypes are associated with increased EA risk...
  42. doi HER2-mediated upregulation of MMP-1 is involved in gastric cancer cell invasion
    Wei Bao
    State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi an 710032, China
    Arch Biochem Biophys 499:49-55. 2010
    ..These findings help further understanding of the molecular mechanisms through which HER2 promotes malignancy, and suggest that targeting both HER2 and MMP-1 may be required to effectively block HER2 signaling in gastric cancer therapy...
  43. ncbi [Association of MMP1 -1607(1G>2G)single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality]
    Wei Qiang Zhang
    Department of Thoracic Surgery, Beijing Army General Hospital, Beijing, 100700 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:313-5. 2006
    b>Matrix metalloproteinase 1 (MMP1) plays an important role in the development of lung cancer...
  44. ncbi Role of MMP-1 1G/2G promoter gene polymorphism on the development of prostate cancer in the Turkish population
    Selami Albayrak
    Clinic of Second Urology, Kartal Training Hospital, Istanbul, Turkey
    Urol Int 79:312-5. 2007
    ..To investigate the association of 1G/2G polymorphism in matrix metalloproteinase-1 (MMP-1) promoter with susceptibility to prostate carcinoma in the Turkish population...
  45. doi Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema
    Alison M Wallace
    University of British Columbia UBC James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, BC, Canada
    COPD 5:13-23. 2008
    ..Alveolar macrophage proteolytic enzymes include cathepsin L, cathepsin S, matrix metalloproteinase 1, 9, and 12, and a number of studies have implicated these proteinases in the alveolar destruction that ..
  46. doi Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis
    Y Chen
    Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, Staffordshire, UK
    Genes Immun 13:29-37. 2012
    ....
  47. doi Variation of matrix metalloproteinase 1 and 3 haplotypes and their serum levels in patients with rheumatoid arthritis and osteoarthritis
    Somia H Abd-Allah
    Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Genet Test Mol Biomarkers 16:15-20. 2012
    ..Moreover, MMP1 and MMP3 polymorphisms may predict the activity and severity of these diseases...
  48. ncbi The expression of matrix metalloproteinase-1 mRNA induced by ultraviolet A1 (340-400 nm) is phototherapy relevant to the glutathione (GSH) content in skin fibroblasts of systemic sclerosis
    Lei Yin
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Dermatol 30:173-80. 2003
    ..These data support the concept that clinical responses to UVA1 radiation are influenced by the antioxidative state of the patients' skin...
  49. ncbi Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma
    Alicja Jozkowicz
    Department of Molecular Genetics, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 50:677-89. 2003
    ....
  50. doi Prognostic value of matrix metalloproteinase-1/ proteinase-activated receptor-1 signaling axis in hepatocellular carcinoma
    Mingmei Liao
    National Hepatobiliary and Enteric Surgery Research Center, Central South University, Changsha, Hunan, 410008, Peoples Republic of China
    Pathol Oncol Res 18:397-403. 2012
    ..Our results suggest for the first time that the MMP-1/PAR-1 signaling axis might be applied as a novel marker for the prediction of recurrence and metastasis potency and a significant indicator of poor prognosis for patients with HCC...
  51. pmc The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma
    Richard Keld
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Mol Cancer 9:313. 2010
    ..The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers...
  52. ncbi Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Science 289:1202-6. 2000
    ..This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response...
  53. pmc Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis
    G Astrid Limb
    Department of Pathology, Institute of Ophthalmology, University College London and Moorfields Eye Hospital, 11 Bath St, London EC1V 9EL
    Am J Pathol 166:1555-63. 2005
    Since the first description of matrix metalloproteinase (MMP)-1 as an interstitial collagenase, great importance has been ascribed to this enzyme in extracellular matrix remodeling during tumoral, inflammatory, and angiogenic processes...
  54. ncbi Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease
    Kinya Okamoto
    Division of Medicine and Clinical Science, Tottori University School of Medicine, Yonago, Japan
    J Gastroenterol Hepatol 20:1102-8. 2005
    ..The aim of this study was to examine the possible association of MMP-1, MMP-3, and MMP-9 gene polymorphisms with the progression of chronic liver disease in the Japanese population...
  55. ncbi Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction
    Eve Pearce
    Human Genetics Division, School of Medicine, University of Southampton, United Kingdom
    Circ Res 97:1070-6. 2005
    ..Haplotype-specific differences in MMP1 mRNA level in atherosclerotic tissues were also detected. The data indicate that MMP1 gene variation is a genetic factor contributing to interindividual differences in MI risk...
  56. ncbi Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population
    Claudia Maria Astolfi
    Oral Biology Program, University of Sagrado, Coração Bauru, SP, Brazil
    J Clin Periodontol 33:699-703. 2006
    ..The aim of this study was to investigate the relationship between these genetic variations with chronic periodontitis in a Brazilian population...
  57. doi A polymorphism at -1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at -519A/G in MMP-1
    Sung Il Nam
    Department of Otolaryngology, School of Medicine, Kyung Hee University, Seoul, Korea
    Laryngoscope 121:171-5. 2011
    ..Two common etiologies for sudden deafness (SD) are circulatory disturbance and inflammation. The present study aimed to investigate whether MMP-1 polymorphisms are associated with SD...
  58. ncbi Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer
    Hung Cheng Lai
    Department of Obstetrics and Gynecology, Tri Service General Hospital, Taipei, 325, Sec 2 Cheng Gung Road, Taipei 114, Taiwan, ROC
    Gynecol Oncol 96:314-9. 2005
    ..b>Matrix metalloproteinase 1 (MMP-1) is an important modulator of carcinogenesis...
  59. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility
    Giorgio Ghilardi
    Dipartimento di Medicina Chirurgia e Odontoiatria, Clinica Chirurgica Generale, Universita degli Studi di Milano, Polo S Paolo, I 20142 Milan, Italy
    Clin Cancer Res 8:3820-3. 2002
    ..The aim of this pilot study was to evaluate the impact of this 5A/6A polymorphism on susceptibility and metastasis in breast cancer...
  60. ncbi The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells
    Grant B Tower
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Breast Cancer Res Treat 82:75-82. 2003
    ..We conclude that ERK 1/2 signaling and the 2G SNP mediate high levels of MMP-1 expression, which may contribute to the invasive potential of these breast cancer cells...
  61. ncbi Correlation between functional genotypes in the matrix metalloproteinases-1 promoter and risk of oral squamous cell carcinomas
    Shu Chun Lin
    School of Dentistry, National Yang Ming University, Taipei, Taiwan
    J Oral Pathol Med 33:323-6. 2004
    ..This genotype is associated with risks of cancer genesis and metastasis. In this paper, we studied the relationship between such genotype and areca-associated oral diseases...
  62. ncbi The use of allelic expression differences to ascertain functional polymorphisms acting in cis: analysis of MMP1 transcripts in normal lung tissue
    J Heighway
    Roy Castle Lung Cancer Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Ann Hum Genet 69:127-33. 2005
    Summary Aberrant expression of matrix metalloproteinase 1 (MMP1) has been implicated in a number of pathological conditions of the lung...
  63. ncbi Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture
    Min P Kim
    Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 78:195-201. 2005
    ..These observations provide insight into the association between hypertension and acute coronary syndrome and a possible mechanism by which Ang-converting enzyme inhibitor and aspirin may reduce the risk for heart attacks...
  64. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances oral squamous cell carcinoma susceptibility in a Chinese population
    Zheng guo Cao
    Key Lab for Oral Biomedical Engineering of Ministry of Education, Wuhan University, Wuhan, People s Republic of China
    Oral Oncol 42:32-8. 2006
    ..The results showed that a SNP in the MMP-1 promoter -1607 bp was associated with OSCC susceptibility in a Chinese population...
  65. pmc Expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in ulcerative colitis
    Ying De Wang
    Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
    World J Gastroenterol 12:6050-3. 2006
    ..To examine the expression of metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the colonic mucosa of patients with ulcerative colitis (UC)...
  66. pmc The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer
    A Hettiaratchi
    Inflammatory Diseases Research Unit, Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Br J Cancer 96:783-92. 2007
    ..Although our results were unexpected, given that this genotype is associated with enhanced MMP-1 transcriptional activity, they are consistent with recent data highlighting the anti-tumorigenic properties of MMPs...
  67. pmc Expression of matrix metalloproteinase-1 and tumor necrosis factor-alpha in ulcerative colitis
    Ying De Wang
    Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
    World J Gastroenterol 13:5926-32. 2007
    ..To examine the expression of matrix metallo-proteinase-1 (MMP-1) and tumor necrosis factor-alpha (TNF-alpha) in the colon mucosa of patients with ulcerative colitis (UC)...
  68. ncbi Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population
    Li Jiang Tang
    Department of Cardiology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang 317000, China
    Clin Biochem 40:1427-30. 2007
    ..To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM)...
  69. ncbi Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain
    A J Fosang
    Orthopaedic Molecular Biology Research Unit, Melbourne University, Royal Children s Hospital, Parkville, Australia
    FEBS Lett 430:186-90. 1998
    ..The data are consistent with MT1-MMP cleavage at three sites in the aggrecan interglobular domain; one at N342-F342, a second at D441-L442 and a third at Q354-T355...
  70. ncbi Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen
    J A Dumin
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:29368-74. 2001
    ....
  71. ncbi Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals. Role of calcium-dependent protein kinase C alpha
    Paul M Reuben
    Department of Medicine, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 277:15190-8. 2002
    ....
  72. ncbi Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells
    Hui Bin Sun
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Matrix Biol 21:263-70. 2002
    ..These results support a potential role of mechanical strain in down-regulating the cytokine-mediated proteolytic processes in synoviocytes...
  73. ncbi Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
    G Angus McQuibban
    Department of Biochemistry and Molecular Biology and the Biomedical Research Centre, University of British Columbia, Vancouver, Canada
    Blood 100:1160-7. 2002
    ..We propose that MMPs have an important role in modulating inflammatory and immune responses by processing chemokines in wound healing and in disease...
  74. ncbi Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis
    Giorgio Ghilardi
    Dipartimento di Medicina, Chirurgia, e Odontoiatria, Clinica Chirurgica Generale, Università degli Studi di Milano Polo S Paolo, Milan, Italy
    Stroke 33:2408-12. 2002
    ..The aim of this study was to investigate a possible association between MMP polymorphisms and increased risk of internal carotid artery (ICA) stenosis...
  75. ncbi MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population
    A P de Souza
    Departments of Morphology, Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Clin Periodontol 30:154-8. 2003
    ..In this paper, we studied the possible relationship between the MMP-1 promoter polymorphism and the severity of chronic periodontitis...
  76. pmc Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 as biomarkers of ulcerative colitis activity
    Alicja Wiercinska-Drapalo
    Department of Infectious Diseases, Intestinal Diseases Unit, Medical University of Bialystok, 15 540 Bialystok, Zurawia str, 14, Poland
    World J Gastroenterol 9:2843-5. 2003
    ..The aim of this study was to evaluate the effect of ulcerative colitis (UC) on MMP-1 and TIMP-1 plasma concentrations, as two possible biomarkers of the disease activity...
  77. ncbi Matrix metalloproteinase-1 polymorphism of promoter region in sarcoidosis and tuberculosis patients
    Shigemitsu Ninomiya
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 21:19-24. 2004
    ..This polymorphism, 1G/2G, has been reported to associate with several malignant tumors and lung diseases. In this study, we investigated whether this polymorphism is associated with sarcoidosis or tuberculosis...
  78. pmc Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis
    Sylvia Dörr
    Institute of Human Genetics, University of Halle Saale, Germany
    Arthritis Res Ther 6:R199-207. 2004
    ..The matrix metalloproteinases MMP1 (interstitial collagenase) and MMP3 (stromelysin 1) are thought to be important in destructive joint changes seen in RA...
  79. ncbi Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis
    Manami Itagaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Periodontol 31:764-9. 2004
    ..The aim of this study was to investigate whether these gene promoter polymorphisms were associated with the susceptibility to periodontitis...
  80. ncbi Interstitial collagenase is a Brownian ratchet driven by proteolysis of collagen
    Saveez Saffarian
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 306:108-11. 2004
    ..The biological implications of MMP-1 acting as a molecular ratchet tethered to the cell surface suggest new mechanisms for its role in tissue remodeling and cell-matrix interaction...
  81. ncbi Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer
    Franck Zinzindohoue
    INSERM U490, Laboratoire de Toxicologie Moléculaire, 45 Rue des Saintes Pères, 75006 Paris, France
    Clin Cancer Res 11:594-9. 2005
    ..A polymorphism in the promoter region of the MMP-1 gene leads to a variation of its level of transcription...
  82. ncbi PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    Adrienne Boire
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Cell 120:303-13. 2005
    ..These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion...
  83. ncbi DHPLC analysis of the matrix metalloproteinase-1 promoter 1G/2G polymorphism that can be easily used to screen large population
    Enping Xu
    Department of Pathology and Pathophysiology, Center for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China
    J Biochem Biophys Methods 63:222-7. 2005
    ..The genotypes of MMP-1 1G/2G revealed by DHPLC analysis were further confirmed by DNA sequencing. In conclusion, DHPLC is a cost-effective, rapid, sensitive, and high-throughput technique for MMP-1 1G/2G genotyping...
  84. ncbi Association of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population
    Zhengguo Cao
    Department of Periodontology, School of Stomatology, Wuhan University, Wuhan, China
    J Periodontal Res 40:427-31. 2005
    ..A single nucleotide polymorphism in the promoter region of -1607 bp of the human matrix metalloproteinase-1 (MMP-1) gene has been found to be associated with an increased risk of various inflammatory diseases and cancer metastasis...
  85. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  86. ncbi Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:18722-31. 2007
    ..These data indicate H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role...
  87. ncbi Matrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    Clin Chim Acta 384:57-63. 2007
    ..The aim of this study was to investigate the susceptibility and prognostic implications of the MMP-1 (-1607) 1G/2G and MMP-9 (-1562) C/T polymorphisms in nasopharyngeal carcinomas...
  88. ncbi Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma
    Gangqiao Zhou
    The State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Hum Mutat 28:1091-7. 2007
    ..Our findings suggest that the genetic polymorphisms or haplotype in the MMP2 promoter may play a role in mediating the susceptibility to NPC in Chinese populations...
  89. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  90. ncbi Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness
    Christine Armstrong
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Stroke 38:2895-9. 2007
    ..We have therefore sought to address this issue in a large, well-phenotyped community population to assess the effect of a number of polymorphisms in both MMP and TIMP genes on carotid artery intima-media thickness (IMT)...
  91. ncbi A single-nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances bladder cancer susceptibility
    Ali I Tasci
    Department of Urology, Bakirkoy Dr Sadi Konuk Research and Teaching Hospital, Istanbul, Turkey
    BJU Int 101:503-7. 2008
    ..To explore the association between the promoter polymorphism (that influences the transcriptional level) of matrix metalloproteinase-1 (MMP-1, associated with tumour cell invasion and metastasis) and bladder cancer in a Turkish population...
  92. ncbi Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis
    Han Pin Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun Hwa N Rd, Taipei, Taiwan
    Tuberculosis (Edinb) 88:262-7. 2008
    ..1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity...
  93. ncbi Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
    Ayumi Honda
    Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Dermatol Sci 49:63-72. 2008
    ..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
  94. doi Impact of matrix metalloproteinase-1 gene variations on risk of acute coronary syndrome
    Yaling Han
    Department of Cardiology, Cardiovascular Research Institute of PLA, Shenyang Northern Hospital, Shenyang, China
    Coron Artery Dis 19:227-30. 2008
    ..This case-control study was conducted to investigate whether genetic variations in the matrix metalloproteinase-1 gene promoter were related to risk of acute coronary syndrome (ACS)...
  95. doi Matrix metalloproteinase-1 promoter is associated with body mass index in Korean population with aged greater or equal to 50 years
    Young Kyun Nho
    Department of Preventive Medicine, School of Medicine, and Institute for Medical Genetics, Keimyung University, 194 Dong San Dong, Jung Gu, Daegu 700 712, Republic of Korea
    Clin Chim Acta 396:14-7. 2008
    ..We investigated whether inter-individual variability in the risk of obesity was associated with a crucial fibrillar collagen-degrading enzyme matrix metalloproteinase (MMP)-1 polymorphisms (MMP1-1607 and MMP1-519)...
  96. doi Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis
    Demet Pirhan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 35:862-70. 2008
    ....
  97. doi MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis
    Marco Checa
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Apartado Postal 21 630, Coyoacan, Mexico DF, CP 04000, Mexico
    Hum Genet 124:465-72. 2008
    ..3; CI 1.15-4.97). These findings indicate that polymorphisms of the MMP-1 promoter may confer increased risk for IPF and reveal a putative gene-environment interaction between the -755 MMP-1 polymorphism and smoking in this disease...
  98. ncbi Matrix metalloproteinase-1 is a crucial bone metastasis factor in a human breast cancer-derived highly invasive cell line
    Noritaka Okuyama
    Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 20:1497-504. 2008
    ..We therefore concluded that MMP-1 plays a crucial role in breast cancer bone metastasis. Furthermore, our MDA-231-derived cell lines are useful analytical models of MMP-1- associated breast cancer bone metastasis...
  99. doi Urokinase receptor, MMP-1 and MMP-9 are markers to differentiate prognosis, adenoma and carcinoma in thyroid malignancies
    Daniel Buergy
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Mannheim Faculty, University of Heidelberg, and DKFZ Heidelberg, Mannheim, Germany
    Int J Cancer 125:894-901. 2009
    ..This is the first study to suggest MMP-1/-9 as significant differentiation markers between follicular adenoma and follicular carcinoma...
  100. ncbi MMP-1 polymorphism and its relationship to pathological processes
    P A Arakaki
    University Federal of Parana, Centro Politecnico, Rua Francisco H dos Santos, Jd, das Americas, 81531 990, Curitiba PR, Brazil
    J Biosci 34:313-20. 2009
    ..MMP-1 is the most ubiquitously expressed interstitial collagenase and has a prominent role in initial cleavage of the ECM...
  101. pmc Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma
    Christopher Ricketts
    Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK
    PLoS ONE 4:e6037. 2009
    ..Hence we hypothesised that low-penetrance functional genetic variants in pathways related to the VHL protein (pVHL) function might (a) modify the phenotypic expression of VHL disease and/or (b) predispose to sporadic RCC...

Research Grants66

  1. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
    ..Inhibiting MMP-1 gene expression may, therefore, be useful in therapeutically controlling melanoma metastasis. ..
  2. Suresh C Tyagi; Fiscal Year: 2016
    ..The results of the proposed research should uncover the molecular mechanisms regulating Hcy-Fg-Ab-collagen complex formation and lead to effective strategies for the treatment of cerebrovascular complications during diseases such as AD. ..
  3. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    ..abstract_text> ..
  4. Suresh C Tyagi; Fiscal Year: 2015
    ..Chronic stress leads to mitochondrial mitophagy and activation of MMP-9 and MMP-13 (an interstitial collagenase in rodent and MMP-1 in human)...
  5. Apoptosis and Fibrosis
    ARIEL R JOHNSON; Fiscal Year: 2013
    ..Elucidation of these mechanisms will identify opportunities for therapeutic intervention in fibrosis. ..
  6. Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung Transplant
    Meera Subramaniam; Fiscal Year: 2010
    ..MMP-8 is an interstitial collagenase, highly expressed by polymorphonuclear cells (PMNs), and also present in fibroblasts...
  7. ANDREA W PAGE-MCCAW; Fiscal Year: 2015
    ..To accomplish these aims we have garnered support from a broad team of experts to inform and guide our experiments. ..
  8. TGF-beta receptor signaling in scleroderma
    MARIA TROJANOWSKA TROJANOWSKA; Fiscal Year: 2012
    ....
  9. ACE Inhibition and Novel Cardiovascular Risk Factors
    Marco Pahor; Fiscal Year: 2004
    ..abstract_text> ..
  10. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ....
  11. Redox-Control of MMP-1 and Senescence
    JUAN ANDRES MELENDEZ; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Matrix metalloproteinase-1 (MMP-1) or interstitial collagenase is a secreted protein which contributes to the etiology of many age-related degenerative diseases...
  12. Vascularization of polymeric tissue beds
    Horst A von Recum; Fiscal Year: 2010
    ..Successful completion of the research will generate fundamental insights into the requirements needed for developing vascular networks in engineered tissue constructs and facilitate translation into clinical applications. ..
  13. JEANINE M D'ARMIENTO; Fiscal Year: 2016
    ..Upon completion of this proposal our goal is to determine whether the collagenolytic enzymes are a therapeutic target in emphysema and whether this pathway is useful as a disease susceptibility marker. ! ..
  14. MMP1-PAR1 Signaling in Vascular Integrity During Sepsis
    Caitlin J Foley; Fiscal Year: 2013
    ..proteases, including thrombin and activated protein C (APC), and by the zinc-dependent collagenase, matrix metalloprotease 1 (MMP1)...
  15. CTRIP: MMP1-PAR1-based Interventions in Arterial Thrombosis
    Athan Kuliopulos; Fiscal Year: 2010
    ....
  16. Athan Kuliopulos; Fiscal Year: 2016
    ....
  17. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..the alpha-myosin heavy chain promoter we have created a transgenic mouse which constitutively expresses interstitial collagenase in the heart...
  18. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2004
    ..is based on this concept and the following three lines of evidence: (1) we have demonstrated that interstitial collagenase expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated ..
  19. PURIFICATION & STUDY OF HUMAN KERATINOCYTE COLLAGENASE
    Marta Petersen; Fiscal Year: 1991
    ..Modulation of collagenase production will be studied with known stimulators and inhibitors of fibroblast collagenase, protein kinase C pathway analogues and growth factors...
  20. Role of Matrix Metalloproteinase-2 in Liver Fibrosis
    Meena Bansal; Fiscal Year: 2007
    ..Its role in acting as an interstitial collagenase will be assessed by 1) comparing the rate of spontaneous resolution of fibrosis between MMP-2 -/- and MMP-..
  21. PEPTIDE INHIBITORS OF EXTRACELLULAR MATRIX PROTEASES
    THOMAS VANAMAN; Fiscal Year: 1993
    ..The three target enzymes are human skin fibroblast collagenase (most active against type III collagen), human skin fibroblast type IV collagenase, and human neutrophil ..
  22. C
    MICHAEL SMAR; Fiscal Year: 1992
    ..will also be tested for the ability to inhibit other physiologically important proteases such as interstitial collagenase and stromelysin...
  23. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ....
  24. SIGNAL PATHWAY--INTERSTIT COLLAGE TRANSCRIPT
    Matthew Vincenti; Fiscal Year: 2001
    b>Interstitial collagenase is an enzyme produced by synovial fibroblasts which contributes to the pathophysiology of rheumatoid arthritis...
  25. STROMELYSINS IN HUMAN HEAD AND NECK TUMORS
    Bente Birkedal Hansen; Fiscal Year: 1993
    ..a more distantly related member, SL-3, which exhibits about the same levels of homology with SL-1/2 and interstitial collagenase (40%)...
  26. EXTRACELLULAR MATRIX DEGRADATION IN SKIN
    George Stricklin; Fiscal Year: 1993
    ..of the dermal extracellular matrix is mediated by a metalloproteinase family which includes interstitial collagenase, gelatinase, and stromelysin...
  27. DIFFERENTIAL GENE EXPRESSION IN SCLERODERMA FIBROBLASTS
    JOSEPH KORN; Fiscal Year: 2002
    ..abstract_text> ..
  28. KARYN MARIE AUSTIN; Fiscal Year: 2015
    ..Finally, the efficacy of PAR1 targeted pepducins will be tested as therapies for the treatment and prevention of vascular neointimal formation. ..
  29. Trauma to Developing Brain-Injury and Repair Mechanisms
    Linda J Noble; Fiscal Year: 2013
    ..Together, these studies provide an important foundation for understanding the unique vulnerability of the young brain to TBI and for developing the most appropriate therapies for the brain-injured child. ..
  30. Mechanistic Analysis of TIMP-1 Induction of EMT
    Rebecca Bigelow; Fiscal Year: 2007
    ..Finally, these in vitro observations will be related to clinical data to assess potential correlations between TIMP-1, E-cadherin, Beta-catenin, PAI-1 and prognosis and mortality of breast carcinoma patients. ..
  31. Protease-activated receptors in vascular integrity and dysfunction
    Athan Kuliopulos; Fiscal Year: 2010
    ....
  32. Studies on the Post-translational processing of MUC1
    Michael A Hollingsworth; Fiscal Year: 2012
    ..This renewal application will investigate the mechanisms by which MUC1 is involved in signal transduction and transcriptional regulation, and how this influences invasion and metastasis of pancreatic tumor cells. ..
  33. Inter-Cellular Signaling of Invastion Receptors in the Tumor Microenvironment
    Athan Kuliopulos; Fiscal Year: 2010
    ..As envisioned, these studies will develop the first inhibitors of these invasion and chemokine receptors for the potential treatment of advanced breast and ovarian cancers. ..
  34. Kytai Truong Nguyen; Fiscal Year: 2016
    ..canines mimics the consequences of restrictive lung disease and is a robust model of compensatory lung growth (CLG), characterized by early alveolar cellular proliferation-hypertrophy, progressive septal remodeling, gradual ..
  35. TERESA BORRAS; Fiscal Year: 2016
    ..We expect that completion of this project will provide all needed preclinical efficacy and safety requirements for setting up a Phase I clinical trial for the treatment of steroid glaucoma patients. ..
  36. PhScN as a Potent Agent for Use with Radiation in Pancreatic Cancer
    DONNA LUCY LIVANT; Fiscal Year: 2013
    ..Moreover, it also represents the first time that alpha5 beta1 integrin has been targeted in pancreatic cancer. ..
  37. Shou Jiang Gao; Fiscal Year: 2016
    ..This project will investigate the mechanism underlining the development of Kaposi's sarcoma, and identify potential targets for the prevention and treatment of this disease. ..
  38. LOUIS JUSTINE VUGA; Fiscal Year: 2014
    ....
  39. CYTOSKELETAL SIGNALING AND AXON GUIDANCE
    Erik A Lundquist; Fiscal Year: 2013
    ..Aim 2 also is designed to test the role of the Cdc42 GEFs UIG-1/Clg and EXC-5/Fgd1 on regulation of CDC-42 in axon pathfinding...
  40. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..tolerance-dependence and abstinence processes and (c) peptides like Pro-Leu-Gly-NH2 (MIF) and cyclo(Leu-Gly) (CLG) inhibit morphine tolerance-dependence and abstinence processes by affecting DA and opiate receptors...
  41. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    ..cascades conferring FGFR1/FGFR2-regulated gene expression in osteoblasts, using osteocalcin (OC) and interstitial collagenase (MMP) FGF response elements (FREs) as models for study...
  42. ECM PROTEASES IN INFLAMMATION, FIBROSIS & TUMORIGENESIS
    Gregory Goldberg; Fiscal Year: 2000
    ..avenues of investigation has been developed aimed at elucidation of cell surface activation mechanism of interstitial collagenase (Cl1)...
  43. MMP1 & MMP9: Mechanism of Activation & Substrate Binding
    Gregory Goldberg; Fiscal Year: 2009
    ..Specific Aims 2 and 3 propose to start with the gelatinase model to define biochemical interactions of gelatinases with substrate and to examine how these can enable processive diffusion and enzyme activation. ..
  44. Mechanism of Triplex DNA Damage and Repair in Skin Cells
    Dennis Oh; Fiscal Year: 2007
    ..of the proposed project is to understand and manipulate how TFOs target psoralen photoadducts to the interstitial collagenase gene in skin derived cells, and to identify the molecular basis for repair of this unusual macromolecular ..
  45. DDR2, a Novel Collagen Receptor, and Mineralization
    Mitsuo Yamauchi; Fiscal Year: 2006
    ..e. rodent interstitial collagenase and gelatinase)...
  46. Alpha2Beta1 Integrin and Cell Surface MMP-1 Activity
    Samuel Santoro; Fiscal Year: 2006
    ..An illustrative example of physiologically relevant spatial regulation of proteolysis is seen with matrix metalloproteinase 1 (MMP-1, collagenase 1) in human cutaneous wounds...
  47. HOST RESPONSE TO TB AND AIDS
    William Rom; Fiscal Year: 2006
    ..This study is critical in developing efficacious treatment strategies for TB and demonstrating that rIFN-gamma ameliorates the lung fibrosis and destruction in advanced TB. ..
  48. REGULATION OF RETINAL PIGMENTED EPITHELIAL ECMS
    Ted Acott; Fiscal Year: 1993
    ..RPE cells were shown to secrete MMP-1 (interstitial collagenase), MMP-2 (gelatinase), MMP-3 (stromelysin) and the tissue inhibitor of metalloproteinases (TIMP)...
  49. Identifying Therapeutic Targets for MPNST
    Shyra Miller; Fiscal Year: 2007
    ..Another gene, matrix metalloproteinase 1 (MMP1), can cause tumor cell invasion and was dramatically overexpressed in a subset of MPNST...
  50. CENTRAL HIGHLANDS APPAL LEADERSHIP INITIATIVE ON CANCER
    Gilbert Friedell; Fiscal Year: 1999
    ..We propose to organize District Coalitions (DC) and Community Leadership Groups (CLG) to promote systems change in communities and facilitate the development, implementation, maintenance, and ..
  51. MMP EXPRESSION IN A NOVEL IN VITRO WOUND HEALING MODEL
    Nadeem Karimbux; Fiscal Year: 2001
    ..In Aim 3 expression of MT-MMP-1 and gelatinase A will be examined by immunofluorescence with anti-MT-MMP-1 and MMP-2 antibodies, Western analysis of wound extracts, and gelatin zymography of culture medium. ..
  52. Nitric Oxide Regulation of Compensatory Lung Growth
    VICTOR LAUBACH; Fiscal Year: 2005
    ..in rapid growth of the remaining lung, the stimuli and molecular mechanisms of this compensatory lung growth (CLG) remain unknown...
  53. Regeneration and transdetermination of imaginal discs of Drosophila
    GEROLD A SCHUBIGER; Fiscal Year: 2010
    ..genes such as alr-like, a gene orthologous to the mouse gene augmenter of liver regeneration (alr), Matrix metalloproteinase 1 (Mmp1), and dReg, a novel gene that contains a C-lectin domain...
  54. Protease Activated Receptors in Cancer Invasion
    Lidija Covic; Fiscal Year: 2009
    ..Aim 3 will use cell-penetrating pepducins to evaluate PARs as potential therapeutic targets in the treatment of breast cancer using both in vitro and mouse model systems. ..
  55. Use of matrix metalloproteinase to improve myogenic cell transplantation in MDX m
    Yong Li; Fiscal Year: 2009
    ..If successful, we expect that this approach would increase the clinical applicability of myogenic transplantation therapy. ..
  56. MMP1 TARGETED RIBOZYMES FOR RESTENOSIS
    Joan Robbins; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATIONS: Immusol, Inc. plans to develop MMP-1 targeted ribozymes for use in the prevention of restenosis following PTCA. ..
  57. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..We have recently observed that membrane type 1 matrix metalloproteinase 1 (MT 1-MMP) transcription is differentially regulated by oscillatory shear and cyclic strain...
  58. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2009
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  59. MMPs in neural networking
    Katherine Conant; Fiscal Year: 2006
    ..The results of our studies should improve our understanding of those CNS inflammatory diseases that are characterized by elevated levels of MMPs. [unreadable] [unreadable] [unreadable]..
  60. MMPs and Synaptic Injury with HIV/METH
    Katherine Conant; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..hypothesized further that stimulated epithelial cells elaborate factors that induce production of MMP-1 (interstitial collagenase) by adjacent fibroblasts. Together, these events bring about invasion...
  62. HIV 1 PROTEINS AND DRUGS OF ABUSE AND METALLOPROTEASES
    Katherine Conant; Fiscal Year: 2003
    ..We will also examine the mechanisms by which these substances may affect MMP production, and identify clinically tolerable compounds which may inhibit such production. ..
  63. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  64. MMPS IN HIV DEMENTIA: EFFECTS ON BBB STRUCTURE/FUNCTION
    Katherine Conant; Fiscal Year: 2003
    ..Also, the proposed studies will use both primary brain-derived HIV isolates, which differ from laboratory adapted strains, and normal human cells, which also differ significantly from those of rodent or tumor origin. ..
  65. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2006
    ..abstract_text> ..
  66. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..