MLC1

Summary

Gene Symbol: MLC1
Description: megalencephalic leukoencephalopathy with subcortical cysts 1
Alias: LVM, MLC, membrane protein MLC1
Species: human

Top Publications

  1. ncbi Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone
    Di Zhang
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Houston, Texas 77030, USA
    J Biol Chem 277:37430-8. 2002
  2. pmc Mutations of MLC1 (KIAA0027), encoding a putative membrane protein, cause megalencephalic leukoencephalopathy with subcortical cysts
    P A Leegwater
    Department of Clinical Chemistry, Free University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Hum Genet 68:831-8. 2001
  3. ncbi Sequence diversity of KIAA0027/MLC1: are megalencephalic leukoencephalopathy and schizophrenia allelic disorders?
    Claudia Rubie
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Hum Mutat 21:45-52. 2003
  4. ncbi A case of megalencephalic leukoencephalopathy with subcortical cysts (van der Knaap disease): molecular genetic study
    Harumi Saijo
    Tokyo Metropolitan Higashiyamato Medical Center for the Severely Disabled, 3 44 10 Sakuragaoka, Higashiyamato, Tokyo 207 0022, Japan
    Brain Dev 25:362-6. 2003
  5. ncbi Genetic heterogeneity of megalencephalic leukoencephalopathy and subcortical cysts
    C Patrono
    Unit of Molecular Medicine and Division of Pediatric Neurology, Bambino Gesu Children s Hospital, Rome, Italy
    Neurology 61:534-7. 2003
  6. ncbi A common mutation and a novel mutation in Japanese patients with van der Knaap disease
    Seiichi Tsujino
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Hum Genet 48:605-8. 2003
  7. ncbi Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts
    Oscar Teijido
    Department of Biochemistry and Molecular Biology, Josep Samitier 1 5 Barcelona E 08028, Spain
    Hum Mol Genet 13:2581-94. 2004
  8. ncbi Vacuolating megalencephalic leukoencephalopathy with subcortical cysts: functional studies of novel variants in MLC1
    Giorgia Montagna
    Molecular Medicine, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
    Hum Mutat 27:292. 2006
  9. ncbi Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1
    P K Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Mutat 27:505-12. 2006
  10. pmc MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet
    Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Acta Neuropathol 114:403-10. 2007

Research Grants

  1. EFFECT OF TSH ON THYROID METABOLISM
    WILLIAM DEERY; Fiscal Year: 1991
  2. MLC Dephosphorylation in Smooth Muscle Cell Apoptosis
    Fabeha Fazal; Fiscal Year: 2002
  3. Wen Wang; Fiscal Year: 2015
  4. Patrick J Tighe; Fiscal Year: 2015
  5. ANGARA KONETI RAO; Fiscal Year: 2016
  6. Patrice Delafontaine; Fiscal Year: 2015
  7. HTS ASSAYS FOR INHIBITORS OF PROTEIN INTERACTIONS INCLUDING MLCK1-FKBP8
    Jerrold R Turner; Fiscal Year: 2012
  8. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2013
  9. Analysis of Protein Dynamics in C. elegans by mLC/MS/MS
    Michael MacCoss; Fiscal Year: 2013
  10. Lei Wei; Fiscal Year: 2016

Detail Information

Publications250 found, 100 shown here

  1. ncbi Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone
    Di Zhang
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Houston, Texas 77030, USA
    J Biol Chem 277:37430-8. 2002
    ..Biol. Chem. 276, 47542-47549), it is likely that MCL1, an anti-apoptotic protein inducible by growth and differentiation stimuli, stabilizes another anti-apoptotic protein fortilin maximizing the prosurvival environment in cells...
  2. pmc Mutations of MLC1 (KIAA0027), encoding a putative membrane protein, cause megalencephalic leukoencephalopathy with subcortical cysts
    P A Leegwater
    Department of Clinical Chemistry, Free University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Hum Genet 68:831-8. 2001
    ..informative and six uninformative families were found in one of the candidate genes, KIAA0027, which we renamed "MLC1." The gene encodes a putative membrane protein with eight predicted transmembrane domains...
  3. ncbi Sequence diversity of KIAA0027/MLC1: are megalencephalic leukoencephalopathy and schizophrenia allelic disorders?
    Claudia Rubie
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Hum Mutat 21:45-52. 2003
    The aim of the study is to validate the etiological role of KIAA0027/MLC1 in childhood-onset megalencephalic leukoencephalopathy with subcortical cysts (MLC) and in schizophrenia, particularly the catatonic subtype, which were reported to ..
  4. ncbi A case of megalencephalic leukoencephalopathy with subcortical cysts (van der Knaap disease): molecular genetic study
    Harumi Saijo
    Tokyo Metropolitan Higashiyamato Medical Center for the Severely Disabled, 3 44 10 Sakuragaoka, Higashiyamato, Tokyo 207 0022, Japan
    Brain Dev 25:362-6. 2003
    ..revealed that the mutations in the gene, KIAA0027, were responsible for MLC and the gene was renamed subsequently 'MLC1'...
  5. ncbi Genetic heterogeneity of megalencephalic leukoencephalopathy and subcortical cysts
    C Patrono
    Unit of Molecular Medicine and Division of Pediatric Neurology, Bambino Gesu Children s Hospital, Rome, Italy
    Neurology 61:534-7. 2003
    ..A broad spectrum of pathogenetic mutations (missense, splice site, insertion, and deletions) were identified in the MLC1 gene, enlarging the spectrum of allelic variants without a straightforward genotype-phenotype correlation...
  6. ncbi A common mutation and a novel mutation in Japanese patients with van der Knaap disease
    Seiichi Tsujino
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Hum Genet 48:605-8. 2003
    ..Recently, the MLC1 gene was identified as the gene responsible for this disorder, and mutations in this gene were described in several ..
  7. ncbi Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts
    Oscar Teijido
    Department of Biochemistry and Molecular Biology, Josep Samitier 1 5 Barcelona E 08028, Spain
    Hum Mol Genet 13:2581-94. 2004
    Mutations in the MLC1 gene are responsible for one form of the neurological disorder megalencephalic leukoencephalopathy with subcortical cysts (MLC). The disease is a type of vacuolating myelinopathy...
  8. ncbi Vacuolating megalencephalic leukoencephalopathy with subcortical cysts: functional studies of novel variants in MLC1
    Giorgia Montagna
    Molecular Medicine, IRCCS Bambino Gesù Children s Hospital, Rome, Italy
    Hum Mutat 27:292. 2006
    ..presenting vacuolating myelinopathy with subcortical cysts were identified and analyzed for variations in the MLC1 gene. We detected 12 mutations (p.Leu37fs, p.Met80Val, p.Leu83Phe, p.Pro92Ser, p.Ser93Leu, p.Ile108fs, p...
  9. ncbi Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1
    P K Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Mutat 27:505-12. 2006
    ..MLC is caused by mutations in the gene MLC1, which encodes a novel protein, MLC1. Since the first report, 50 mutations in this gene have been found...
  10. pmc MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet
    Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Acta Neuropathol 114:403-10. 2007
    ..cysts (MLC) is a progressive cerebral white matter disease with onset in childhood, caused by mutations in the MLC1 gene...
  11. doi MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation
    Angela Lanciotti
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurobiol Dis 37:581-95. 2010
    ..leukoencephalopathy with subcortical cysts (MLC) is a rare congenital leukodystrophy caused by mutations in the MLC1 gene that encodes a membrane protein of unknown function...
  12. pmc The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis
    Maria S Brignone
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Hum Mol Genet 20:90-103. 2011
    ..leucoencephalopathy with subcortical cysts (MLC) is a rare congenital leucodystrophy caused by mutations in MLC1, a membrane protein of unknown function...
  13. doi Identification of novel MLC1 mutations in Chinese patients with megalencephalic leukoencephalopathy with subcortical cysts (MLC)
    Jingmin Wang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Hum Genet 56:138-42. 2011
    ..with subcortical cysts (MLC) is an autosomal, recessively inherited disease caused by mutations in the MLC1 gene. Most of the previously published studies have been carried out in ethnic populations other than the Chinese...
  14. pmc Knockdown of MLC1 in primary astrocytes causes cell vacuolation: a MLC disease cell model
    Anna Duarri
    Seccion de Fisiologia, Departamento de Ciencias Fisiologicas II, Universidad de Barcelona, Spain
    Neurobiol Dis 43:228-38. 2011
    ..with subcortical cysts (MLC) is a rare type of leukodystrophy, in the majority of cases caused by mutations in the MLC1 gene...
  15. doi Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts
    Tania López-Hernández
    Seccion de Fisiologia, IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, Spain
    Hum Mol Genet 20:3266-77. 2011
    Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy caused by mutations in MLC1 or GLIALCAM. The GLIALCAM gene product functions as an MLC1 beta-subunit...
  16. doi Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations
    Angela Lanciotti
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Hum Mol Genet 21:2166-80. 2012
    ..characterized by macrocephaly, subcortical fluid cysts and myelin vacuolation, has been linked to mutations in the MLC1 gene. This gene encodes a membrane protein that is highly expressed in astrocytes...
  17. ncbi A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree
    J Meyer
    Department of Psychiatry and Psychotherapy, University of Wurzburg, D 97080 Wurzburg, Germany
    Mol Psychiatry 6:302-6. 2001
    ....
  18. ncbi Identification of novel mutations in MLC1 responsible for megalencephalic leukoencephalopathy with subcortical cysts
    P A J Leegwater
    Department for Clinical Chemistry, Free University Medical Center, Amsterdam, The Netherlands
    Hum Genet 110:279-83. 2002
    ..Mutations in the MLC1 gene, encoding a putative membrane protein, have been recently identified as a cause for MLC...
  19. ncbi Megalencephalic leukoencephalopathy with subcortical cysts; a founder effect in Israeli patients and a higher than expected carrier rate among Libyan Jews
    Bruria Ben-Zeev
    Sackler School of Medicine, Tel Aviv University, Israel
    Hum Genet 111:214-8. 2002
    ..The disease is caused by mutations in the MLC1 gene, which encodes a putative CNS membrane transporter. We describe three novel mutations (p.G59E, p...
  20. doi Biochemical characterization of MLC1 protein in astrocytes and its association with the dystrophin-glycoprotein complex
    Elena Ambrosini
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Mol Cell Neurosci 37:480-93. 2008
    b>MLC1 gene mutations have been associated with megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare neurologic disorder in children...
  21. ncbi MLC1: a novel protein in distal astroglial processes
    P K Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 64:412-9. 2005
    ..with subcortical cysts (MLC) is a progressive cerebral white matter disease in children caused by mutations in the MLC1 gene. This disease is histopathologically characterized by myelin splitting and intramyelinic vacuole formation...
  22. ncbi [Good response to ganciclovir in a patient of cytomegalovirus (CMV) interstitial pneumonitis and gastric ulcer following allogeneic bone marrow transplantation for acute lymphoblastic leukemia]
    S Mizuno
    Bone Marrow Transplantation Group of Miyazaki Prefectural Hospital
    Kansenshogaku Zasshi 69:213-7. 1995
    ..Ten months later she underwent bone marrow transplantation (BMT) from her HLA-identical and MLC-negative sister...
  23. ncbi Determinants of left ventricular mass in normotensive children
    F A Trieber
    Medical College of Georgia, Department of Pediatrics, Augusta
    Am J Hypertens 6:505-13. 1993
    ..Few studies have examined the determinants of left ventricular mass (LVM) in normotensive children...
  24. ncbi Dietary calcium induces regression of left ventricular hypertrophy in hypertensive non-insulin-dependent diabetic blacks
    M B Zemel
    Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan
    Am J Hypertens 3:458-63. 1990
    ..of calcium supplementation on forearm blood flow (FBF) and vascular resistance (FVR) and left ventricular mass (LVM) in seven type II diabetic hypertensive black men with left ventricular hypertrophy (LVH) maintained off ..
  25. ncbi Effect of antihypertensive treatment on cardiac and subcutaneous artery structure: a comparison between calcium channel blocker and thiazide-based regimens
    I Sihm
    Department of Medicine and Cardiology, Aarhus University Hospital, Denmark
    Am J Hypertens 11:263-71. 1998
    ..Left ventricular mass (LVM) index was determined by echocardiography according to the Penn convention...
  26. pmc Inhibition of antiskin allograft immunity induced by infusions with photoinactivated effector T lymphocytes (PET cells)
    M I Perez
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510
    Yale J Biol Med 62:595-609. 1989
    ..Recipient mice were tested for tolerance to alloantigens in mixed leukocyte culture (MLC), cytotoxicity (CTL), delayed-type hypersensitivity assays (DTH), and challenge with a fresh CBA/j graft...
  27. ncbi Rest and effort hemodynamic responses during prolonged treatment with felodipine, 24-h blood pressure monitoring, and echocardiographic changes
    R Zimlichman
    Department of Medicine, Hypertension and The Donolo Institute of Physiological Hygiene, Wolfson Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
    Am J Hypertens 10:905-12. 1997
    ..Left ventricular mass (LVM) was determined before and at the end of treatment...
  28. ncbi Echocardiographic measurement of left ventricular mass and volume in normotensive and hypertensive rats. Necropsy validation
    G De Simone
    Department of Medicine, New York Hospital-Cornell Medical Center, New York City, NY 10021
    Am J Hypertens 3:688-96. 1990
    ..echocardiography in rats, blinded crossectional area (CSA) and LV mass measurements using either the cube function (LVM) or an elliptical model (LVMel) from high resolution M-mode echocardiograms were compared to necropsy LV weight (0...
  29. ncbi In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression
    H Ramseier
    Institute for Immunology and Virology, , Switzerland
    Immunopharmacol Immunotoxicol 15:557-82. 1993
    ..T cell responses as a consequence of recognition of alloantigens, as measured in mixed lymphocyte cultures (MLC), were affected in an analogous way...
  30. ncbi Reliability of the capacity factor at zero micellar concentration and the solute-micelle association constant estimates by micellar liquid chromatography
    F Argilés
    Departamento de Quimica Analitica, Facultad de Farmacia, Universidad de Valencia, Spain
    J Chromatogr A 778:67-75. 1997
    In micellar liquid chromatography, MLC, the hydrophobicity of a compound is the predominant effect on its retention and interaction with micelles...
  31. ncbi Left ventricular geometric patterns and QT dispersion in untreated essential hypertension
    Z Bugra
    Department of Cardiology, Istanbul Faculty of Medicine, University of Istanbul, Turkiye
    Am J Hypertens 11:1164-70. 1998
    ..Left ventricular mass (LVM), body mass index, total peripheral resistance (TPR), relative wall thickness (RWT), and QT dispersion were found ..
  32. ncbi Left ventricular hypertrophy and its regression: pathophysiology and therapeutic approach: focus on treatment by antihypertensive agents
    M P Schlaich
    Department of Medicine IV, , , Germany
    Am J Hypertens 11:1394-404. 1998
    ..In fact, increased echocardiographic left ventricular mass (LVM) has been shown to predict cardiovascular complications not only in patients with arterial hypertension, but also ..
  33. ncbi [Effects of verapamil and nifedipine on blood pressure during rest and exertion and on left ventricular hypertrophy]
    P Gosse
    , Pessac
    Arch Mal Coeur Vaiss 85:1249-52. 1992
    ..with nifedipine 20 mg SR (N) or verapamil 240 mg SR (V) on rest and exercise BP and left ventricular mass (LVM) and function were evaluated in 31 essential hypertensive patients (mean age: 54, 19 males, 12 females), never ..
  34. ncbi Central obesity and hypertension: the role of plasma endothelin
    G Parrinello
    Department of Internal Medicine, University of Palermo, Italy
    Am J Hypertens 9:1186-91. 1996
    ..mean blood pressure (MBP/24 h) by noninvasive ambulatory blood pressure monitoring, left ventricular mass/ height (LVM/H), and left ventricular ejection fraction (LVEF) by echocardiography and peak filling rate (PFR) by radionuclide ..
  35. ncbi Fluorinated bonded stationary phases in micellar liquid chromatography
    S Yang
    Department of Chemistry, North Carolina State University, Raleigh 27695
    J Chromatogr A 664:1-11. 1994
    The usefulness of fluorinated bonded stationary phases in micellar liquid chromatography (MLC) is examined...
  36. ncbi [Do WHO-ISH guidelines identify high risk mild hypertensive patients?]
    G Chatellier
    Service d Informatique Médicale, Hopital Broussais, Paris
    Arch Mal Coeur Vaiss 91:967-70. 1998
    ..To assess the ability of 1993 WHO-ISH recommendations to identify patients who need drug treatment...
  37. ncbi Pharmaceutical applications of micelles in chromatography and electrophoresis
    H Nishi
    Analytical Research Laboratory, Tanabe Seiyaku Co, Osaka, Japan
    J Chromatogr A 780:243-64. 1997
    ..stationary phases such as octadecylsilylized silica gel (ODS) columns is known as micellar liquid chromatography (MLC)...
  38. ncbi Computer systems analysis of spaceflight induced changes in left ventricular mass
    Richard L Summers
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Comput Biol Med 37:358-63. 2007
    ..It has been postulated that a decrement in left ventricular mass (LVM) found after microgravity exposure may be the central component in this cardiovascular deconditioning...
  39. ncbi Noninvasive detection of vascular dysfunction in alcoholic patients
    G Maiorano
    Hypertension Group, Internal Medicine I, University of Bari, Italy
    Am J Hypertens 12:137-44. 1999
    ..Esaote Au3) according to guidelines of the American Society of Echocardiography to assess left ventricular mass (LVM), wall thickness, systolic stress, and diastolic function changes...
  40. ncbi [Left ventricular hypertrophy and ambulatory blood pressure]
    P Gosse
    , Pessac
    Arch Mal Coeur Vaiss 84:101-5. 1991
    ..value of ambulatory blood pressure recording; the observation of better correlations between left ventricular mass (LVM) and systolic BP with ambulatory rather than clinical recordings is one of the most convincing arguments in favour ..
  41. ncbi [Determinants of left ventricular hypertrophy in hypertensive subjects that have never been treated: role of the sodium intake]
    G du Cailar
    Policlinique, , Montpellier
    Arch Mal Coeur Vaiss 82:1105-8. 1989
    ..Posterior wall thickness (PWT) and left ventricular mass (LVM) were measured by M-mode echocardiography and sodium intake was estimated from urinary sodium excretion rate (UNa, ..
  42. pmc Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery
    A Suzuki
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 109:703-12. 1993
    ..CL-A, an inhibitor of type 1 and 2A phosphatases) on mechanical activities, phosphorylation of myosin light chain (MLC) and the relationship between the two were studied in Ca(2+)-free solution containing 4 mM EGTA and these effects ..
  43. ncbi Correction of left ventricular ischemia in blacks with hypertensive heart disease
    A A Carr
    Department of Medicine, Medical College of Georgia, Augusta 30912-3150
    Am J Hypertens 6:271S-276S. 1993
    ..ischemia documented by 201Tl-myocardial imaging also had a significant reduction in left ventricular mass (LVM)...
  44. ncbi [Evaluation by Doppler echocardiography of systolic and diastolic functions of the left ventricle of the athlete's heart]
    A Cohen
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 82:55-62. 1989
    ..T-mode echocardiographic parameters were determined: wall thickness and cavitary diameter, left ventricular mass (LVM), fibre shortening fraction (FSF) and ejection fraction (EF)...
  45. ncbi Murine fetal liver augments proliferation in an allogenic mixed lymphocyte culture: benzo(a)pyrene reduces augmentation
    P Urso
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30208, USA
    Immunopharmacol Immunotoxicol 17:181-200. 1995
    ..These data indicate that: a) FL cells syngeneic to responder cells of an allogenic mixed lymphocyte culture (MLC) have an augmenting but not suppressive capacity on cell proliferation; b) in utero insult with BP modifies the ..
  46. ncbi [Dynamic left ventricular obstruction increased by nitroglycerin in elderly patients with hypertension and concentric left ventricular hypertrophy]
    A Cohen
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 83:1155-60. 1990
    ..3 in all patients). LVM could be calculated in 15 patients and was corrected for body surface area (LVMI)...
  47. ncbi Predicting heart growth during puberty: The Muscatine Study
    K F Janz
    Department of Sport, Health, and Leisure Studies, University of Iowa, Iowa City 52242, USA
    Pediatrics 105:E63. 2000
    ..and longitudinal relationships among aerobic fitness, body size, blood pressure (BP), and left ventricular mass (LVM) through puberty including the predictors of heart growth during puberty and the tracking of LVM from pre-puberty ..
  48. ncbi Micellar liquid chromatography for prediction of drug transport
    M Molero-Monfort
    , Universidad de Valencia, Burjassot, Spain
    J Chromatogr A 870:1-11. 2000
    ..In this paper, a new in vitro method, based on the retention data in micellar liquid chromatography (MLC), is validated for the prediction of passive drug absorption...
  49. ncbi [Coronary reserve in treated hypertension with persistent left ventricular hypertrophy]
    I Antony
    Service d'Explorations Fonctionnelles, INSERM U251, groupe hospitalier Bichat-Claude-Bernard, Paris
    Arch Mal Coeur Vaiss 84:1043-6. 1991
    ..In 26 patients with normal coronary arteriography, end-diastolic wall thickness (EDWT), LV mass (LVM) and peak systolic LVWS were determined on 30 degrees right anterior oblique LV angiography with simultaneous ..
  50. ncbi [Myocardial morphological changes related to sodium intake in normotensive and hypertensive patients never treated before]
    G du Cailar
    Policlinique, , Montpellier, France
    Arch Mal Coeur Vaiss 83:2045-9. 1990
    ..Posterior wall thickness (PWT) and left ventricular mass (LVM) were measured by M-mode echocardiography and urinary sodium excretion (UNa, mmol/24h) was taken as an index of ..
  51. ncbi Effects of spironolactone-altizide on left ventricular hypertrophy
    S Degre
    , , Brussels, Belgium
    Acta Cardiol 53:261-7. 1998
    ..Additionally, to study the correlation between left ventricular mass (LVM) index and electrocardiographic (ECG) criteria for LVH...
  52. ncbi The impact of acemannan on the generation and function of cytotoxic T-lymphocytes
    D Womble
    Department of Internal Medicine, Vanderbilt University, Nashville, Tennessee 37232-2372
    Immunopharmacol Immunotoxicol 14:63-77. 1992
    ..To investigate whether acemannan directly stimulated the generation of Tc from primary mixed lymphocyte cultures (MLC), the drug was added at the initiation of the MLC...
  53. ncbi Influence of left ventricular hypertrophy on the diastolic performance in hypertensive patients and in athletes
    N Lefkos
    2nd Department of Internal Medicine, Aristotelian University, Thessaloniki, Greece
    Acta Cardiol 48:507-14. 1993
    ..EDD, ESD) the wall thickness (IVST, PWT) and their ratio (IVST/PWT), the ejection fraction (EF), the mass (LVM) and the index mass (I mass) of the left ventricle (LV) as well as the dimension (LA) and the emptying index (LAEI) ..
  54. ncbi A weight reduction and weight maintenance program with long-lasting improvement in left ventricular mass and blood pressure
    E Himeno
    Department of Health Development, University of Occupational and Environmental Health, Nishino Hospital, Japan
    Am J Hypertens 12:682-90. 1999
    ..risk factor for cardiovascular disease and is associated with hypertension and increased left ventricular mass (LVM). Maintenance of reduced weight has been a matter of recent concerns in the treatment of obese subjects...
  55. ncbi Determinants of left ventricular mass in untreated mildly hypertensive subjects: hospitalet study in mild hypertension
    P Armario
    Department of Internal Medicine, Red Cross Hospital, Hospitalet de Llobregat, Barcelona, Spain
    Am J Hypertens 12:1084-90. 1999
    ..Left ventricular mass (LVM) was analyzed as a continuous variable...
  56. ncbi Micellar liquid chromatographic separation of sulfonamides in physiological samples using direct on-column injection
    S Yang
    Department of Chemistry, North Carolina State University, Raleigh 27695-8204
    J Chromatogr A 692:311-8. 1995
    A mixture of twelve sulfonamides was separated by micellar liquid chromatography (MLC) using sodium dodecyl sulfate (SDS) micelles and a hydrophilic endcapped C18 column...
  57. ncbi The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cells
    S Takata
    Department of Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 3:227S-230S. 1990
    ..production, cytosolic Ca2+ concentration [( Ca2+]i), and the phosphorylation of 20 kilodalton myosin light chain (MLC) were examined in cultured rat vascular smooth muscle cells (VSMC)...
  58. ncbi [Ventriculoarterial coupling and left ventricular performance in hypertensive patients with left ventricular hypertrophy]
    A Nitenberg
    Service de Physiologie et d'Explorations Fonctionnelles, INSERM U 426, , CHU Xavier-Bichat, Colombes
    Arch Mal Coeur Vaiss 90:1025-30. 1997
    ..subjects (CS) showed that LV contractile performance assessed by Ees/100 g left ventricular myocardial mass (LVM, echocardiographic determination) was depressed (HT: 4.35 +/- 1.13; CS: 5.21 +/- 1.89 mmHg/ml/100 g; p < 0...
  59. ncbi [Correlation between QT interval dispersion and ventricular arrhythmia in hypertension]
    S Balanescu
    Service de cardiologie, , Roumanie
    Arch Mal Coeur Vaiss 89:987-90. 1996
    ..Left ventricular mass was determined by echocardiography (LVM-Devereux formula) and left ventricular mass index (LVMI) were determined in 202 subjects...
  60. ncbi Early minilaparoscopic cholecystectomy in patients with acute cholecystitis
    Chi Hsun Hsieh
    Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5, Fu Hsing St, Kwei Shan, 333, Taoyuan, Taiwan
    Am J Surg 185:344-8. 2003
    ..instruments (2 or 3 mm in diameter) for laparoscopic cholecystectomy, called minilaparoscopic cholecystectomy (MLC), were reported to be superior to conventional LC (CLC, using 5 mm instruments) in postoperative course and ..
  61. ncbi Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus
    Piotr Moleda
    Klinika Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii PAM, ul Arkonska 4, 71 455 Szczecin, Poland
    Kardiol Pol 64:959-65; discussion 966. 2006
    ..Type 2 diabetes mellitus is probably related to increased left ventricular mass (LVM). Existing data show that the renin-angiotensin-aldosterone (RAA) system may play a role in the development of LVH...
  62. ncbi [Mid-term echographic evaluation of systolic function after cardiac transplantation]
    J Julien
    , , Paris, France
    Arch Mal Coeur Vaiss 83:495-500. 1990
    The aim of this study was to analyse variations in left ventricular mass (LVM) and systolic function after cardiac transplantation and to evaluate eventual changes induced by the onset of systemic hypertension (HT)...
  63. ncbi Lack of correlation between left ventricular mass and diameter of left coronary artery main trunk in hypertensive patients
    C Cuspidi
    Istituto di Clinica Medica Generale e Terapia Medica and Centro Fisiologia Clinica e Ipertensione, , IRCCS, Milano, Italy
    Am J Hypertens 12:1163-8. 1999
    ..5 and r = 0.4, P<.05). Our data suggest that in H the increase in LVM is not associated with a concomitant increase of epicardial coronary artery diameter, and this finding may account ..
  64. ncbi Reversal of left ventricular hypertrophy in hypertensive patients. A metaanalysis of 109 treatment studies
    B Dahlof
    Department of Medicine, University of Goteborg, Ostra Hospital, Goteborg, Sweden
    Am J Hypertens 5:95-110. 1992
    ..Overall left ventricular mass (LVM) was reduced by 11.9% [95% confidence interval (CI) 10.1 to 13...
  65. ncbi Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta
    Seigo Fujimoto
    Department of Cellular and Molecular Pharmacology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Eur J Pharmacol 459:65-73. 2003
    ..relaxation of the norepinephrine-contraction were studied by measuring isometric force, myosin light chain (MLC(20)) phosphorylation and cyclic GMP in endothelium-denuded muscle from the guinea-pig aorta. Norepinephrine (5...
  66. ncbi [Blood pressure variability and morbidity]
    P Balansard
    Service de cardiologie, , Toulon
    Arch Mal Coeur Vaiss 83:1089-93. 1990
    ..Furthermore, we have showed a weaker correlation between absolute variability (AV) and left ventricular mass (LVM)...
  67. ncbi Assessment of left ventricular hypertrophy in patients with essential hypertension. A rational basis for the electrocardiogram
    P V Fragola
    Department of Internal Medicine, School of Cardiovascular Diseases, II University of Rome, Italy
    Am J Hypertens 6:164-9. 1993
    ..years) with mild to moderate essential hypertension, using echocardiographically determined left ventricular mass (LVM) as the standard for comparison...
  68. doi Cardiac dysfunction in an animal model of neonatal asphyxia is associated with increased degradation of MLC1 by MMP-2
    Adrian Doroszko
    Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Basic Res Cardiol 104:669-79. 2009
    ..hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in ..
  69. pmc Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase
    Tanchun Wang
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Physiol Renal Physiol 297:F1534-42. 2009
    Smooth muscle contraction is regulated by phosphorylation of the myosin light chain (MLC) catalyzed by MLC kinase and dephosphorylation catalyzed by MLC phosphatase...
  70. ncbi Prognostic value of left ventricular mass and its evolution during treatment in the Bordeaux cohort of hypertensive patients
    C Cipriano
    , Centre Hospitalier Universitaire de Bordeaux, France
    Am J Hypertens 14:524-9. 2001
    ..a cohort of initially untreated hypertensive patients with echocardiographic measurements of left ventricular mass (LVM)...
  71. pmc In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
    Y Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059
    J Cell Biol 124:129-37. 1994
    Phosphorylation of the regulatory light chain of myosin II (MLC) controls the contractility of actomyosin in nonmuscle and muscle cells...
  72. ncbi Adenosine induces dephosphorylation of myosin II regulatory light chain in cultured bovine corneal endothelial cells
    S P Srinivas
    School of Optometry, Indiana University, 800 Atwater Ave, Bloomington, IN 47405, USA
    Exp Eye Res 79:543-51. 2004
    Dephosphorylation of the myosin II regulatory light chain (MLC) promotes barrier integrity of cellular monolayers through relaxation of the actin cytoskeleton...
  73. ncbi Characterization of capsaicin-induced, capsazepine-insensitive relaxation of ileal smooth muscle of rats
    Seigo Fujimoto
    Department of Cellular and Molecular Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho cho, Muzuho, Nagoya 467 8601, Japan
    Eur J Pharmacol 487:175-82. 2004
    ..were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileal longitudinal smooth muscles of rats...
  74. ncbi Linear solvation energy relationships in micellar liquid chromatography and micellar electrokinetic capillary chromatography
    S Yang
    Department of Chemistry, North Carolina State University, Raleigh 27695-8204
    J Chromatogr A 692:301-10. 1995
    ..and characterize chemical interactions that influence retention behavior in micellar liquid chromatography (MLC) and micellar electrokinetic capillary chromatography (MEKC)...
  75. doi Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation
    Ariadna Yolanda Ruiz-Loredo
    Division de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    J Cell Physiol 226:414-23. 2011
    ..We analyzed thrombin effect on signaling pathways leading to myosin light chain (MLC) phosphorylation and actin stress fiber formation in primary cultures of rat RPE cells, in order to support a role ..
  76. ncbi Magnetic resonance imaging compared to echocardiography to assess left ventricular mass in the hypertensive patient
    P B Bottini
    Department of Medicine, Medical College of Georgia, Augusta, USA
    Am J Hypertens 8:221-8. 1995
    Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient...
  77. ncbi [Semi-automatic measurement of the left ventricular mass from tomodensitometric traces of the left ventricle]
    P Gosse
    , CHU Bordeaux
    Arch Mal Coeur Vaiss 92:961-3. 1999
    To improve the standardisation and reproductibility of echocardiographic left ventricular mass (LVM) measurements we developed a specific software for automated measurements of LV diameter (EDD) and wall thickness (ST&PWT) from M ..
  78. ncbi Use of an amorphous silicon electronic portal imaging device for multileaf collimator quality control and calibration
    S J K Baker
    North Western Medical Physics, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Phys Med Biol 50:1377-92. 2005
    Multileaf collimator (MLC) calibration and quality control is a time-consuming procedure typically involving the processing, scanning and analysis of films to measure leaf and collimator positions...
  79. ncbi [Sensitivity and specificity of criteria of left ventricular hypertrophy for predicting cardiovascular complications in the Bordeaux cohort of hypertensive patients]
    P Gosse
    , , rue Jean-Burguet, 33075 Bordeaux
    Arch Mal Coeur Vaiss 94:771-4. 2001
    ..a cohort of initially untreated hypertensive patients with echocardiographic measurements of left ventricular mass (LVM)...
  80. ncbi Induction and characterization of minor histocompatibility antigens. Specific primary cytotoxic T lymphocyte responses in vitro
    K Ando
    Department of Immunology, Nagoya University School of Medicine, Aichi, Japan
    J Immunol 140:723-9. 1988
    A definite cytotoxic activity was developed in a BALB/c (H-2d) anti-DBA/2 primary mixed leukocyte culture (MLC), which received interleukin 2 (IL-2) on day 3 of culture...
  81. ncbi Minilaparoscopic and laparoscopic cholecystectomy: a comparative study
    Ming Te Huang
    Department of Surgery, En Chu Kong Hospital, Taipei, Taiwan
    Arch Surg 138:1017-23. 2003
    To evaluate the feasibility and safety of the minilaparoscopic cholecystectomy (MLC) and to compare the clinical benefits experienced by patients who undergo MLC with those who undergo laparoscopic cholecystectomy (LC) or 5-mm ..
  82. pmc Relation of left ventricular mass and concentric remodeling to extent of coronary artery disease by computed tomography in patients without left ventricular hypertrophy: ROMICAT study
    Quynh A Truong
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Hypertens 27:2472-82. 2009
    Cardiac computed tomography allows for simultaneous assessment of left ventricular mass (LVM) and coronary artery disease (CAD)...
  83. doi Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling
    Misuzu Yamashita
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kitaku, Okayama City, 700 8558, Japan
    Regul Pept 162:99-108. 2010
    ..of simvastatin in osteoclast function and differentiation induced by RANKL and BMP-2 using mouse macrophage-like MLC-6 cells and human osteoclast precursor cells...
  84. ncbi [Normal aging, hypertension and left ventricular filling]
    J P Ollivier
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 83:1143-7. 1990
    ..angiographic peak filling rate (PFR), doppler echocardiographic early E and late A waves, left ventricular mass (LVM), blood pressure (BP) and ejection fraction (EF) in cautiously screened 30 untreated hypertensive and 30 age paired ..
  85. ncbi In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21
    N Sadeg
    Laboratoire de Toxicologie, , Paris, France
    Immunopharmacol Immunotoxicol 15:163-77. 1993
    ..induced by different mitogens (ConA, PHA, PWM) and also on the proliferation of mixed lymphocyte cultures (MLC)...
  86. ncbi Characterization of a new virulent phage (MLC-A) of Lactobacillus paracasei
    M L Capra
    Instituto de Lactología Industrial INLAIN, Facultad de Ingeniería Química Universidad Nacional del Litoral, Santiago del Estero 2829, 3000 Santa Fe, Argentina
    J Dairy Sci 89:2414-23. 2006
    A new virulent bacteriophage (MLC-A) was recently isolated in Argentina from a probiotic dairy product containing a strain of Lactobacillus paracasei...
  87. ncbi [Left ventricular mass and glomerular hyperfiltration in essential hypertension]
    G du Cailar
    Policlinique, , Montpellier
    Arch Mal Coeur Vaiss 83:1161-4. 1990
    ..Left ventricular mass (LVM, M-mode echocardiography), sodium intake (24h UNaV) and urinary kallikrein (Kall) were also measured...
  88. ncbi Utility of electrocardiogram for predicting increased left ventricular mass in asymptomatic men at risk for cardiovascular disease
    N Denarie
    Centre de Medecine Preventive Cardiovasculaire, INSERM CRI, Hopital Broussais, Paris, France
    Am J Hypertens 11:861-5. 1998
    The objective of this study was to test the value of electrocardiogram for predicting left ventricular mass (LVM), assessed echographically in 136 asymptomatic men with at least one major cardiovascular risk factor...
  89. ncbi In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery
    Vitali Moiseenko
    Vancouver Cancer Centre, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
    Med Phys 34:1514-20. 2007
    ..a reference; regular seven-field IMRT, irradiation time 5 min; and IMRT with a break for multiple leaf collimator (MLC) re-initialization after three fields were delivered, irradiation time 10 min...
  90. pmc Functions of the Caenorhabditis elegans regulatory myosin light chain genes mlc-1 and mlc-2
    A M Rushforth
    Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 150:1067-77. 1998
    Caenorhabditis elegans contains two muscle regulatory myosin light chain genes, mlc-1 and mlc-2. To determine their in vivo roles, we identified deletions that eliminate each gene individually and both genes in combination...
  91. ncbi Selection bias in clinical research when subjects are excluded because of failure to estimate left ventricular mass by echocardiography
    G A Whalley
    Cardiovascular Research Laboratory and Clinical Trials Research Unit, Department of Medicine, School of Medicine, University of Auckland, New Zealand
    J Am Soc Echocardiogr 11:1050-5. 1998
    ..The goals of this study were as follows: (1) to determine the frequency with which left ventricular mass (LVM) could be estimated by echocardiography, (2) to characterize persons in whom LVM could not be estimated from ..
  92. ncbi [Role of Rho-Rock pathways induced by angiotensin II in hepatic stellate cell contraction]
    Xiao Lan Zhang
    Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 88:2422-6. 2008
    ..To investigate the mechanism of Ca(2+)-independent pathways mediated by Rho-kinase in contraction of hepatic stellate cells (HSCs) induced by angiotonin II (Ang II)...
  93. doi Effect of agalsidase alfa replacement therapy on Fabry disease-related hypertrophic cardiomyopathy: a 12- to 36-month, retrospective, blinded echocardiographic pooled analysis
    Christoph Kampmann
    Division of Cardiology, University Children s Hospital, Mainz, Germany
    Clin Ther 31:1966-76. 2009
    ..Fabry disease is an X-linked disease caused by a deficiency in the activity of the lysosomal enzyme alpha-galactosidase A. Affected individuals typically develop left ventricular hypertrophy (LVH) among other pathologies...
  94. pmc An MLC calibration method using a detector array
    Thomas A Simon
    Department of Nuclear and Radiological Engineering, University of Florida, 202 Nuclear Science Building, Gainesville, Florida 32611 8300, USA
    Med Phys 36:4495-503. 2009
    The authors have developed a quantitative calibration method for a multileaf collimator (MLC) which measures individual leaf positions relative to the MLC backup jaw on an Elekta Synergy linear accelerator.
  95. ncbi Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells
    C C Kumar
    Department of Tumor Biology, Schering Corporation, Bloomfield, New Jersey 07003
    Biochemistry 28:4027-35. 1989
    The 20-kDa regulatory myosin light chain (MLC), also known as MLC-2, plays an important role in the regulation of both smooth muscle and nonmuscle cell contractile activity...
  96. pmc Thiophosphorylation-induced Ca(2+) sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase
    G Pfitzer
    Department of Physiology and Pathophysiology, University of Cologne, Robert Koch Strasse 39, D 50931 Cologne, Germany
    J Physiol 533:651-64. 2001
    ..with ATP gamma S under conditions that do not lead to thiophosphorylation of regulatory light chains of myosin (r-MLC) increased subsequent Ca(2+) sensitivity of force and r-MLC phosphorylation...
  97. ncbi Pulse pressure is the best predictor of future left ventricular mass and change in left ventricular mass: 10 years of follow-up
    J M Jokiniitty
    Department of Medicine, Medical School, University of Tampere and Department of Internal Medicine, Tampere University Hospital, Finland
    J Hypertens 19:2047-54. 2001
    Ambulatory blood pressure correlates more closely with left ventricular mass (LVM) than casual blood pressure in cross-sectional studies, but prospective evidence is very limited.
  98. ncbi Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase
    Akira Endo
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachussetts, USA
    J Biol Chem 279:42055-61. 2004
    Excitation-contraction coupling in smooth muscle involves activation of myosin light chain (MLC) phosphorylation, which increases activity of the myosin actin-activated ATPase, resulting in contraction...
  99. ncbi Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance
    D Quilliot
    Service de Diabetologie, Maladies Métaboliques et de Nutrition, Hopital Jeanne d Arc, Centre Hospitalier Universitaire de Nancy, Nancy, France
    Int J Obes (Lond) 29:1321-8. 2005
    ....
  100. ncbi An improved MLC segmentation algorithm and software for step-and-shoot IMRT delivery without tongue-and-groove error
    Shuang Luan
    Department of Computer Science, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Med Phys 33:1199-212. 2006
    We present an improved multileaf collimator (MLC) segmentation algorithm, denoted by SLS(NOTG) (static leaf sequencing with no tongue-and-groove error), for step-and-shoot intensity-modulated radiation therapy (IMRT) delivery...
  101. ncbi The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats
    Sheng Zhong
    Dept of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Cell Physiol 293:C723-8. 2007
    ..from a reduced ATPase activity and/or a reduction in the relative content of myosin light chain 3f isoform content (MLC(3f))...

Research Grants63

  1. EFFECT OF TSH ON THYROID METABOLISM
    WILLIAM DEERY; Fiscal Year: 1991
    ..32P, TSH rapidly caused a reduction of 32p in two polypeptides having many characteristics of myosin light chains (MLC)...
  2. MLC Dephosphorylation in Smooth Muscle Cell Apoptosis
    Fabeha Fazal; Fiscal Year: 2002
    ..The information derived from these studies will increase our understanding of cytoskeletal dynamics during apoptosis. ..
  3. Wen Wang; Fiscal Year: 2015
    ..follow-up findings from one of the largest multi-ethnic genome-wide association studies for Left Ventricular Mass (LVM) and Left Ventricular Hypertrophy (LVH)...
  4. Patrick J Tighe; Fiscal Year: 2015
    ..To accurately forecast severe postoperative pain, we propose the use of machine learning classifiers (MLC's), which are classification algorithms employing a range of novel search and classification methodologies ..
  5. ANGARA KONETI RAO; Fiscal Year: 2016
    ..and secretion associated with diminished agonist-stimulated phosphorylation of pleckstrin and myosin light chain (MLC), decreased PKC- and impaired activation of GPIIb-IIIa. This patient has a heterozygous mutation in RUNX1...
  6. Patrice Delafontaine; Fiscal Year: 2015
    ..We will utilize AMPK-KD mice, MLC-IGF-1 mice (muscle specific IGF-1 transgenics), muscle specific IGF-1R-/- mice to assess effects of Ang II on ..
  7. HTS ASSAYS FOR INHIBITORS OF PROTEIN INTERACTIONS INCLUDING MLCK1-FKBP8
    Jerrold R Turner; Fiscal Year: 2012
    ..tight junctions in response to pathogenic stimuli, where it phosphorylates myosin II regulatory light chain (MLC) to reduce barrier function...
  8. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2013
    ..These pathways include primarily the myosin light chain (MLC) kinase, the MLC phosphatase, activated and constitutively active Rho kinases, and protein kinase C (PKC)...
  9. Analysis of Protein Dynamics in C. elegans by mLC/MS/MS
    Michael MacCoss; Fiscal Year: 2013
    ..Furthermore, the proteome-wide measurement of protein turnover in response to insulin-like molecules will produce an experimental dataset for probing the underlying mechanism of insulin signaling. ..
  10. Lei Wei; Fiscal Year: 2016
    ..mechanistic concept that ROCK1 preferentially mediates stress-induced acto-myosin contraction via the ROCK1/MYPT/MLC pathway leading to increased cell death, while ROCK2 preferentially contributes to actin polymerization via the ..
  11. NITRIC OXIDE SIGNALING MECHANISMS IN VASCULAR CELLS
    Michael Mendelsohn; Fiscal Year: 2009
    ..VSMC contractile state is dynamically regulated by phosphorylation of the regulatory myosin light (MLC) chains controlling actinomyosin contraction...
  12. Henri R Ford; Fiscal Year: 2014
    ..It is known that Ca2+ activates myosin light chain kinase (MLCK), leading to MLC phosphorylation and actomyosin contractility...
  13. In Situ Sensing of Single Myosin Function in Hypertrophy Disease
    Thomas P Burghardt; Fiscal Year: 2013
    ..Several MLC mutants are hypothesized to impact lever-arm structural stability influencing lever-arm dynamics and effectiveness...
  14. Enteropathogenic E. coli Effects on Intestinal Function
    Gail A Hecht; Fiscal Year: 2010
    ..can be dissected into 2 events mediated by different effectors: cytoskeletal contraction via myosin light chain (MLC) phosphorylation and endocytosis of TJ proteins...
  15. Mitsuo Ikebe; Fiscal Year: 2016
    ..Smooth muscle contraction is primarily regulated by myosin light chain (MLC) phosphorylation, however, recent studies have suggested that actin cytoskeletal rearrangement may be in part ..
  16. Ethnicity, Stress, and LV Mass
    Carlos Jose Rodriguez; Fiscal Year: 2010
    ..The applicant has provided evidence that echocardiographic LVM is an independent predictor of cardiovascular morbidity and mortality in Hispanics and that Hispanics have higher ..
  17. S MURTHY KARNAM; Fiscal Year: 2016
    ..and G[unreadable]12/Rho-GEF (AKAP-Lbc), which regulate RhoA activity and sustained muscle contraction;and (iii) the MLC phosphatase activators, telokin and p116Rip, which promote MLC20 dephosphorylation (Specific Aim I)...
  18. S MURTHY KARNAM; Fiscal Year: 2016
    ..sustained contraction was mediated via sequential activation of G12, LARG, RhoA/Rho kinase leading to inhibition of MLC phosphatase...
  19. Amit Sawant; Fiscal Year: 2015
    ..In Aim 3, we will investigate real-time beam adaptation using multileaf collimator (MLC) tracking...
  20. Neutrophil-dependent regulation of venular permeability
    Sarah Y Yuan; Fiscal Year: 2011
    ..Comparative analysis of the complex pathways points to a predominant role for myosin light chain (MLC)-mediated contractile force development as a triggering event to open the paracellular pathway for protein leakage ..
  21. Teresa A Zimmers; Fiscal Year: 2015
    ..mice and in mouse models of cancer cachexia, and 3) Determine the contribution of skeletal muscle STAT3 to IL-6 induced wasting and cancer cachexia using skeletal muscle specific STAT3 null mice and our panel of MLC-SOCS3 transgenics.
  22. Regulation of Myosin Phosphorylation in Smooth Muscle
    Mitsuo Ikebe; Fiscal Year: 2013
    ..the mechanism by which the Rho/MLCP (myosin light chain phosphatase) pathway regulates myosin light chain (MLC) phosphorylation and contraction in vascular smooth muscle...
  23. Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury
    Jingsong Xu; Fiscal Year: 2013
    ..The proposed studies have the following specific aims: i) to dissect the myosin light chain (MLC) independent pathway of non-muscle MLCK that is required for the full activation of (2 integrins via the tyrosine ..
  24. MYPT1 phosphatase in smooth muscle
    Mitsuo Ikebe; Fiscal Year: 2012
    ..However, recent studies have suggested that the Ca2+ independent regulation of MLC phosphorylation cannot solely be explained by RhoA/ROCK...
  25. John M Jakicic; Fiscal Year: 2015
    ..The primary outcome is LVM measured by cardiac MRI...
  26. How Does a4B1 Integrin Regulate Cell Migration?
    Joy Yang; Fiscal Year: 2010
    ..association in (a) localization and organization of MIIA;(b) focal adhesion turnover;(c) regulating MLC phosphorylation and filament assembly;and (d) regulating RhoAand FAK-mediated pathways...
  27. Gene-air pollution interactions and cardiac structure and function in MESA and CH
    Victor C Van Hee; Fiscal Year: 2012
    ..to traffic-related air pollution) has been demonstrated to be associated with increased left ventricular mass (LVM), an important intermediate for cardiovascular disease outcomes including heart failure...
  28. Actomyosin motors and Mechanism of Myelin Formation
    Carmen V Melendez Vasquez; Fiscal Year: 2010
    ..our laboratory strongly suggest that regulation of actomyosin assembly via phosphorylation of myosin light chain (MLC) is an important aspect of this process...
  29. STRUCTURE/FUNCTION OF MYOSIN IN SKELETAL MUSCLE
    Gordon Lutz; Fiscal Year: 2001
    ..vertebrates express a multigene family of the two myosin subunits; myosin heavy chain (MHC) and myosin light chain (MLC)...
  30. SCOTT MATTHEW WILLIAMS; Fiscal Year: 2016
    ..population-based genetic studies of pre-clinical cardiovascular disease (CVD) as measured by left ventricular mass (LVM)...
  31. LIPID AND PROTEIN PO4 TURNOVER IN IRIS OF THE EYE
    ATA ABDEL LATIF; Fiscal Year: 1999
    ..Investigate the relationships between PG-induced IP3 accumulation, DG production, MLC phosphorylation, cAMP formation and muscle tension in the iris sphincter of different species. 2...
  32. QSAR STUDIES BY LIPOSOME ELECTROKINETIC CHROMATOGRAPHY
    Morteza Khaledi; Fiscal Year: 2003
    ..the usefulness of Micellar Electrokinetic Capillary Chromatography (MECC) and Micellar Liquid Chromatography (MLC) for prediction of bioactivity through Quantitative Retention -Activity Relationships (QRAR) and for quantitation ..
  33. PROTEIN PHOSPHATASES IN ENDOTHELIAL CELL PERMEABILITY
    JOE GARCIA; Fiscal Year: 2001
    ..Although several PPases can dephosphorylate isolated MLC, myosin-associated PPase properties in endothelium are unknown...
  34. Role of Rho Kinase in Aqueous Humor Outflow Pathway
    P Rao; Fiscal Year: 2004
    ..of Rho/Rho kinase function have contrasting effects not only upon cytoskeletal changes and myosin light chain (MLC) phosphorylation in human trabecular meshwork (HTM) and Schlemm's canal (HSC) cells, but on SC cell monolayer ..
  35. FUNCTIONAL AND MOLECULAR STUDY OF HUMAN MASSETER FIBERS
    James Sciote; Fiscal Year: 2000
    ..of the human primate are the most exceptional, expressing developmental and cardiac MHC and myosin light chain (MLC) isoforms not found in other adult skeletal muscle, as well as the typical adult skeletal isoforms...
  36. CTL DEVELOPMENT BY L-ORNITHINE AND POLYAMINES
    Brian Susskind; Fiscal Year: 1990
    L-Ornithine has been shown to inhibit the development of cytotoxic T lymphocytes (CTL) in mixed lymphocyte cultures (MLC)...
  37. Microfilament organization in mitosis and transformation
    Fumio Matsumura; Fiscal Year: 2009
    ..and cell migration, by defining the specific roles of phosphorylation of the regulatory light chain of myosin II (MLC) in these processes...
  38. Adherens Junction Integrity and Barrier Function
    Fred Minnear; Fiscal Year: 2005
    ..of S1P is independent of cAMP and protein kinases A and G and is not affected by inhibition of myosin light chain (MLC) kinase and extracellular signal-regulated kinase...
  39. Mechanisms of Calmodulin-dependent EC Barrier Regulation
    Alexander Verin; Fiscal Year: 2004
    ..Ca2+ increases, activation of Ca2+/CaM-dependen myosin light chain kinase (MLCK), increases in myosin light chain (MLC) phosphorylation, initiation of actomyosin contraction and finally gap formation and barrier dysfunction...
  40. Myocardial repair by targeted stem cells
    JAMES LARRICK; Fiscal Year: 2009
    ..recognizing the CD34+ enriched SCs was chemically conjugated to an antibody recognizing myosin light chain (MLC) exposed in injured cardiac tissue...
  41. MECHANISMS FOR ALTERED DETRUSOR CONTRACTILITY IN DIABET
    Samuel Chacko; Fiscal Year: 2002
    ..of intravesical pressure and over distension of the diabetic bladder is due to a low level of myosin light chain (MLC) phosphorylation or a change in the site of phosphorylation of the MLC in the detrusor smooth muscle at the resting ..
  42. MOLECULAR CLONING OF THE DR7-ASSOCIATED IA GENES
    Robert Karr; Fiscal Year: 1992
    Among individuals with the serologically defined HLA-DR7 specificity, six distinct mixed lymphocyte culture (MLC)-defined HLA-D specificities have been described: Dw7, Dw11, Dw17, DW7L, Dw11S, and Dw blank...
  43. NEURAL AND MECHANICAL REGULATION OF SLOW MYOSIN
    Karyn Esser; Fiscal Year: 1999
    ..gene that is necessary for slow muscle specific expression in vivo: 2) To determine cis-acting sequences of the MLC 2 slow gene that are necessary for induction in response to slow innervation...
  44. AMANDA LYNSEY JONES; Fiscal Year: 2015
    ..The Mobile Laboratory Coalition (MLC) was formed in 2005 and is now considered an international partnership of mobile science education programs that ..
  45. IMMUNOGENETICS OF SACRAL AGENESIS
    Mark Ballow; Fiscal Year: 1980
    ..of children with sacral agenesis demonstrated that 5/9 patients responded poorly in mixed lymphocyte culture (MLC) to one patient, KL, despite differences at the HLA-D locus...
  46. TGFB INDUCED DECREASE OF ENDOTHELIAL MONOLAYER INTEGRITY
    Peter Vincent; Fiscal Year: 2004
    ..this decrease was temporally associated with intercellular gap formation and an increase in myosin light chain (MLC) phosphorylation...
  47. Vascular Reactivity in Heart Failure
    Frank Brozovich; Fiscal Year: 2006
    ..dependent on 20 kDa myosin light chain (MLC20) phosphorylation levels, which depend on the relative activities of MLC kinase and MLC phosphatase...
  48. Thrombin-induced Signaling in Vascular Smooth Muscle
    George Stouffer; Fiscal Year: 2005
    ..e. 6S). Equilibration between 6S and 10S is sensitive to the phosphorylation state of myosin light chain (MLC)...
  49. ANESTHETIC MECHANISMS IN VASCULAR SMOOTH MUSCLE
    WALTER BOYLE; Fiscal Year: 2005
    ..muscle is initiated by increases in intracellular Ca+2 concentration ([Ca2+]i), which activate myosin light chain (MLC) kinase, thereby resulting in MLC phosphorylation and initiation of contraction...
  50. MECHANISMS OF MINOR H ANTIGEN GVHD
    BRIAN HAMILTON; Fiscal Year: 1992
    ..antigens (minor HA) in two strain combinations selected for H-2 identity and for mutual nonreactivity in MLC: C57BL/6-LP (H-2b combination) and B10.D2/nSn-BALB/c (H-2d combination)...
  51. Mechanisms of VEGF modulation of smooth muscle function
    Reynold Panettieri; Fiscal Year: 2009
    ..The relative efficacy of VEGF receptor-specific ligands to activate Rho, phosphorylate myosin light chain (MLC) and enhance agonist- induced force will be characterized...
  52. ATP in Lung Endothelial Barrier Enhancement
    Alexander Verin; Fiscal Year: 2009
    ..to the disruption of cell-cell contacts and includes activation of contraction initiated by myosin light chain (MLC)phosphorylation followed by F-actin stress fiber formation and formation of paracellular gaps...
  53. PHYSICOCHEMICAL & BIOANALYTICAL STUDIES USING MLC
    Morteza Khaledi; Fiscal Year: 1993
    ..Finally, in the third part, the aim is to demonstrate the unique capabilities of micellar LC for chemical analysis which are especially advantages in solving bioanalytical problems...
  54. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..Myosin light chain (MLC) phosphorylation by MLC kinase (MLCK) is a critical regulatory step in actin-myosin interaction and ensuing ..
  55. Phosphorylation, calcium and smooth muscle contraction
    Robert Moreland; Fiscal Year: 2007
    It is widely accepted that an increase in [Ca2+] initiates contraction by activation of myosin light chain (MLC) kinase and phosphorylation of the 20 kDa MLC...
  56. ADOLESCENT RISK FACTORS AND YOUNG ADULT CARDIAC RISK
    Julia Steinberger; Fiscal Year: 2003
    ..field developed during fellowship when she became interested in the relations among obesity, left ventricular mass (LVM) insulin resistance, and lipids...
  57. CARDIAC PROGENITOR CELL DIFFERENTIATION
    M Siddiqui; Fiscal Year: 2002
    ..the structural domains of Clp-1 that are responsible for binding the B element MEF-2 binding site in the cardiac MLC-2 gene promoter and determine if these same structural domains mediate Clp-1 activation of the cardiac MLC-2 gene ..
  58. MECHANISM OF HUMAN TRANSENDOTHELIAL LEUKOCYTE MIGRATION
    Samuel Silverstein; Fiscal Year: 1999
    ..identify/characterize the substance (s) by stimulated PMN s that increase in EC ((Ca++(i), phosphorylation of EC MLC, and the permeability of EC MLC, and the permeability of EC megalocytes establish the biological properties of this ..
  59. Experimental Analysis of Advanced Radiotherapy Dosimetry
    JAMES DEMPSEY; Fiscal Year: 2007
    ..project is to understand the role of nontrivial systematic errors in the overall accuracy of multileaf collimator (MLC) -based megavoltage (MV) photon-beam intensity modulated radiation therapy (IMRI-) delivery and dose calculation...
  60. REGULATION OF SMOOTH MUSCLE MLC KINASE EXPRESSION
    Steven Fisher; Fiscal Year: 1999
    ..This program is designed to mold Dr. Fisher into productive physician scientist who utilizes basic cell and molecular techniques to study clinically relevant smooth muscle disease processes. ..
  61. Cardiac disease in children with chronic renal failure
    Mark Mitsnefes; Fiscal Year: 2006
    ..Thus, the long-term goal will be to decrease the incidence and prevalence of cardiovascular disease in young adults who developed chronic renal disease during childhood. ..
  62. Laser acceleration of protons for radiation therapy
    Dale Litzenberg; Fiscal Year: 2007
    ..This research will conduct the first critical step in determining if the cost can be dramatically reduced through the use of new acceleration technology. [unreadable] [unreadable] [unreadable]..
  63. Adiponectin and Cardiovascular Disease in the CKiD Children
    Mark Mitsnefes; Fiscal Year: 2009
    ....