Genomes and Genes
Gene Symbol: MKS1
Description: Meckel syndrome, type 1
Alias: BBS13, JBTS28, MES, MKS, POC12, Meckel syndrome type 1 protein, POC12 centriolar protein homolog
Publications177 found, 100 shown here
- Periodic limb movement disorder is associated with normal motor conduction latencies when studied by central magnetic stimulation--successful use of a new techniqueR C Smith
Department of Medicine, Michigan State University, East Lansing 48824
Sleep 15:312-8. 1992..Subjects had no other medical or sleep problems. A novel magnetic stimulator, the Cadwell MES-10, was discharged over the vertex and the C7 cervical spine...
- Extracellular matrix receptors and the differentiation of human megakaryocytes in vitroA Molla
, UMR CNRS UJF 5538, Institut Albert Bonniot, La Tronche, France
Leuk Lymphoma 33:15-23. 1999..of extracellular matrix receptors (or integrins) in the course of the differentiation of human megakaryocytes (Mks) leading to the formation of platelets...
- Meckel syndrome in the Hutterite population is actually a Joubert-related cerebello-oculo-renal syndromeKym M Boycott
Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
Am J Med Genet A 143:1715-25. 2007Meckel syndrome (MKS) is a rare lethal autosomal recessive disorder characterized by the presence of occipital encephalocele, cystic kidneys, fibrotic changes of the liver and polydactyly...
- Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzymeKimie Nakagawa
Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
Nature 468:117-21. 2010..the natural world in several forms, including a plant form, phylloquinone (PK), and a bacterial form, menaquinones (MKs)...
- Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteinsNathan J Bialas
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
J Cell Sci 122:611-24. 2009..An identifying feature of MKS1, one of six MKS-associated proteins, is the presence of a B9 domain of unknown function...
- MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndromeMira Kyttälä
Department of Molecular Medicine, National Public Health Institute, FI 00251 Helsinki, Finland
Nat Genet 38:155-7. 2006..Here we report the identification of a gene, MKS1, mutated in MKS families linked to 17q...
- Molecular diagnostics of Meckel-Gruber syndrome highlights phenotypic differences between MKS1 and MKS3Mark B Consugar
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Hum Genet 121:591-9. 2007..MKS is genetically heterogeneous with three loci mapped and two identified; MKS1 (17q23) and MKS3 (8q22.1)...
- Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. OnlineRana Khaddour
INSERM U 781, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
Hum Mutat 28:523-4. 2007..MKS is genetically heterogeneous and three loci have been mapped respectively on 17q23 (MKS1), 11q13 (MKS2), and 8q24 (MKS3)...
- A disease causing deletion of 29 base pairs in intron 15 in the MKS1 gene is highly associated with the campomelic variant of the Meckel-Gruber syndromeB Auber
Institute of Human Genetics, University of Goettingen, Germany
Clin Genet 72:454-9. 2007..Recently, mutations in the MKS1 gene have been identified as disease causing in individuals of Finnish MKS families...
- Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndromeCarmen C Leitch
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
Nat Genet 40:443-8. 2008..Here we show that mutations in MKS1, MKS3 and CEP290 (also known as NPHP6) either can cause Bardet-Biedl syndrome (BBS) or may have a potential ..
- Displacement chromatography of proteins using a self-sharpening pH front formed by adsorbed buffering species as the displacerC R Narahari
Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore 21250, USA
J Chromatogr A 825:115-26. 1998..of acetic acid and either 3-(N-morpholino)propane-sulfonic acid (MOPS) or 2-(N-morpholino)ethanesulfonic acid (MES). Sample loads up to 150 mg of protein were applied to a 75 x 7...
- Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensationL F Zhang
Department of Aviation Environmental Physiology, Fourth Military Medical College, Xi an
Sci Sin B 31:204-16. 1988..A new kind of category scale, the multistage evaluation scale (MES), based on a fuzzy set category judgement model for quantifying respiratory sensory magnitude has been put forward ..
- Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenilW Loscher
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
Br J Pharmacol 113:1349-57. 1994..The threshold for maximal (tonic) electroshock seizures (MES) was significantly increased by GYKI 52466 (10-20 mg kg-1), NBQX (80-120 mg kg-1) and diazepam (5 mg kg-1) shortly ..
- Trace determination of iron in water at the microgram/l level by on-line coupling of capillary isotachophoresis and capillary zone electrophoresis with UV detection of the EDTA-Fe (III) complexP Blatný
Department of Carbohydrate Chemistry and Technology, Institute of Chemical Technology, Prague, Czech Republic
J Chromatogr A 757:297-302. 1997..1% hydroxypropylmethyl cellulose (pH 6.0), 5 mmol/l MES, and 25 mmol/l MES + 10 mmol/l bis-tris-propane (pH 6...
- Combination of cor triatriatum sinistrum and hypoplastic left heart syndrome in Meckel-Gruber syndrome: a case reportMana Taweevisit
Department of Pathology, Faculty of Medicine, Chulalongkorn University, 1873 King Rama IV Street, Pathumwan, Bangkok, Thailand
Pediatr Dev Pathol 12:404-9. 2009Meckel-Gruber syndrome (MKS) is a fatal, autosomal recessive disorder characterized by malformation of central nervous system, particularly occipital encephalocele, bilateral renal dysplasia, and polydactyly...
- The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndromeLekbir Baala
INSERM U 781, Hopital Necker Enfants Malades, Paris, France
Am J Hum Genet 80:186-94. 2007..obvious phenotypic overlap between JS and MKS, we hypothesized that mutations in the recently identified MKS genes, MKS1 on chromosome 17q and MKS3 on 8q, may be a cause of JS...
- The anticonvulsant activities of N-benzyl 3-methoxypropionamidesS V Andurkar
Department of Chemistry, University of Houston, TX 77204-5641, USA
Bioorg Med Chem 7:2381-9. 1999We recently reported that the ED50 value for (R,S)-2,3-dimethoxypropionamide (1) in the maximal electroshock (MES)-induced seizure test in mice was 30 mg/kg (Choi, D.; Stables, J.P., Kohn, H. Bioorg. Med. Chem. 1996, 4, 2105)...
- Mkks-null mice have a phenotype resembling Bardet-Biedl syndromeMelissa A Fath
Department of Pediatrics, Division of Medcal Genetics, University of Iowa, Iowa City, IA 52242, USA
Hum Mol Genet 14:1109-18. 2005McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia...
- Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndromeCheng Cui
University of Pittsburgh, Department of Developmental Biology, 8111 Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201, USA
Dis Model Mech 4:43-56. 2011..We recovered a mouse mutant with a mutation in the Mks1 gene (Mks1(del64-323)) that caused a 260-amino-acid deletion spanning nine amino acids in the B9 domain, a protein ..
- The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiationWendy A Ciovacco
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA
Bone 44:80-6. 2009..Recently, we reported that megakaryocytes (MKs) enhance osteoblast (OB) proliferation by a juxtacrine signaling mechanism...
- Mutations in MKKS cause Bardet-Biedl syndromeA M Slavotinek
Genetic Diseases Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
Nat Genet 26:15-6. 2000..Some BBS cases (approximately 10%) remain unassigned to the five previously mapped loci. McKusick-Kaufma syndrome (MKS) includes hydrometrocolpos, postaxial polydactyly and congenital heart disease, and is also inherited in an ..
- Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndromeValeska Frank
Department of Human Genetics, RWTH Aachen University, Aachen, Germany
Hum Mutat 29:45-52. 2008..Recently, genes for MKS1 and MKS3 were identified, putting MKS on the list of ciliary disorders (ciliopathies)...
- Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1(low) mice: a possible role in osteosclerosisRama Garimella
University of Kansas Medical Center, Kansas City, KS 66160, USA
J Histochem Cytochem 55:745-52. 2007..However, growth factors released from the bone marrow cells, including from MKs, have been implicated in myelofibrosis, osteosclerosis, and angiogenesis...
- Metabolism and cell biology of vitamin KMartin J Shearer
Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
Thromb Haemost 100:530-47. 2008..vitamin K compounds comprise a plant form, phylloquinone (vitamin K(1)) and a series of bacterial menaquinones (MKs) (vitamin K(2))...
- [5-HT(1A) receptors are involved in the modulation of respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats]Zheng Qin
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Sheng Li Xue Bao 59:293-8. 2007..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O2 and 5% CO2), and ended in 3 min...
- Megakaryocytes and platelets in experimentally induced renovascular hypertension (2K1C) in ratsJoanna Pawlak
Department of Human Anatomy, Medical University of Białystok
Postepy Hig Med Dosw (Online) 62:241-8. 2008..Approximately 10% of the population with hypertension reveals the secondary type of the disease. The aim of the study was to evaluate the megakaryocyte-platelet system in the course of renovascular hypertension...
- [D(1)-dopamine receptor is involved in the modulation of the respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats in vitro.]Yong gang Jiao
Department of Physiology, Southern Medical University, Guangzhou, China
Sheng Li Xue Bao 60:704-8. 2008..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous ventilating 95% O2 and 5% CO2 and ended in 3 min...
- Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytesJosé P Young
Dept of Physiology and Biophysics, Georgetown Univ, Columbia, Washington, DC 20057, USA
Am J Physiol Cell Physiol 298:C602-10. 2010..in a fluctuating fashion, triggering oscillatory outward Ca(2+)-activated K(+) currents in rat megakaryocytes (MKs)...
- Long-term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin-amplified in clinical grade serum-free cultureGianfranco Mattia
Department of Hematology, Oncology and Molecular Medicine, Section of Transfusion Methodologies, Istituto Superiore di Sanita, Rome, Italy
Exp Hematol 36:244-52. 2008..when induced to differentiate along the megakaryocytic (MK) lineage, retention of a low ploidy in the expanded MKs. Ex vivo expansion of CB hematopoietic progenitor cells for reconstitution of different human hematopoietic ..
- [Effect of glial cell metabolism on respiratory rhythmical discharge activity in neonatal rat medulla oblongata slices]Fang Fang
Department of Physiology, Southern Medical University, Guangdong, Guangzhou 510515, China
Nan Fang Yi Ke Da Xue Xue Bao 29:2410-3. 2009..To explore the role of glial cell metabolism in the generation and regulation of central respiratory rhythm...
- The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machineryKoji Eto
Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Japan
Blood 110:3637-47. 2007..While MKs and platelets principally express WAVE1 and WAVE2, which are associated with Abi1, the physiologic significance of ..
- Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzleJonna Tallila
National Public Health Institute, Institute for Molecular Medicine Finland, Helsinki 00290, Finland
Am J Hum Genet 82:1361-7. 2008Meckel syndrome (MKS) is a lethal malformation disorder characterized classically by encephalocele, polycystic kidneys, and polydactyly. MKS is also one of the major contributors to syndromic neural tube defects (NTDs)...
- Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signalingLarissa Lordier
INSERM, U790, Villejuif, France
Blood 112:3164-74. 2008..No abnormality was observed in the central spindle of endomitotic MKs. A furrow formation was present, but the contractile ring was abnormal because accumulation of nonmuscle myosin IIA ..
- Prenatal diagnosis of the Meckel-Gruber syndrome from 11th to 20th gestational weekC Mittermayer
Department of Neonatology and Intensive Care, University Hospital Vienna
Ultraschall Med 25:275-9. 2004The Meckel-Gruber syndrome (MKS) is a rare autosomal recessive disorder that is characterized by typical sonographical findings: occipital encephalocele, postaxial polydactyly and cystic enlargement of the kidneys...
- Microembolic signals and clinical outcome in patients with acute stroke--a prospective studyA Delcker
Department of Neurology, University of Essen, Germany
Eur Arch Psychiatry Clin Neurosci 250:1-5. 2000The occurrence of microembolic signals (MES) in patients with transient ischemic attack (TIA) or stroke has already been described; the influence of the time interval between onset of symptoms and transcranial Doppler monitoring (TCD) on ..
- Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?S Bord
University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Bone 27:397-401. 2000..b>MKs were identified morphologically, and the bone marrow cell population and MK number quantified by cell counting in a ..
- Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regressionAmy E Geddis
Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
Cell Cycle 6:455-60. 2007..We have postulated that anaphase in endomitotic MKs diverges from diploid mitosis at a point distal to the assembly of the midzone, possibly involving impaired ..
- CD41+/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocytic population in murine bone marrowKuniko Matsumura-Takeda
Molecular Medical Science Institute, Otsuka Pharmaceutical Co Ltd, 463 10 Kagasuno, Tokushima, Japan
Stem Cells 25:862-70. 2007Murine megakaryocytes (MKs) are defined by CD41/CD61 expression and acetylcholinesterase (AChE) activity; however, their stages of differentiation in bone marrow (BM) have not been fully elucidated...
- New perspectives on keratoconus as revealed by corneal confocal microscopyNathan Efron
Institute of Health and Biomedical Innovation and School of Optometry, Queensland University of Technology, Brisbane, Australia
Clin Exp Optom 91:34-55. 2008Confocal microscopy (CM) of keratoconus is reviewed. In the Manchester Keratoconus Study (MKS), slit scanning CM was used to evaluate 29 keratoconic patients and light microscopy (LM) was performed on two of the keratoconic corneas post-..
- [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]Zhi bin Qian
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Sheng Li Xue Bao 60:216-20. 2008..DOI), and an antagonist of 5-HT(2A) receptor, ketanserine, dissolved in modified Krebos solution (MKS)...
- Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidyDonald J McCrann
Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
Blood 114:1243-9. 2009Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy...
- Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4Corey L Williams
Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA
J Am Soc Nephrol 21:782-93. 2010..to renal cyst formation in multiple human syndromes including nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Joubert syndrome (JBTS), and Bardet-Beidl syndrome (BBS)...
- [Effect of doxapram on the respiratory rhythmical discharge activity in the brainstem slice of neonatal rats]Guo cai Li
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Nan Fang Yi Ke Da Xue Xue Bao 30:245-8. 2010..To investigate the effects of doxapram on the respiratory rhythmical discharge activity (RRDA) in the brainstem slices of neonatal rats...
- The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytesP Rojnuckarin
Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Biol Chem 276:41014-22. 2001..ERK/mitogen-activated protein kinase pathway is important for TPO-induced endomitosis in primary megakaryocytes (MKs)...
- Classical Swine Fever: pathology of bone marrowJ C Gomez-Villamandos
Departamento Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Cordoba, Spain
Vet Pathol 40:157-63. 2003..Megakaryocytes (MKs) did not show significant changes in number, but there were important qualitative changes including 1) increased ..
- Identification and activation of Src family kinases in primary megakaryocytesBrian J Lannutti
Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
Exp Hematol 31:1268-74. 2003..In this study, we examine which of the eight Src family members are expressed in primary megakaryocytes (MKs) and determine which of these become activated in response to TPO.
- Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) miceLucia Centurione
Department of Biomorphology, University G D Annunzio, Chieti, Italy
Blood 104:3573-80. 2004..blocks megakaryocytic maturation between stage I and II, resulting in accumulation of defective megakaryocytes (MKs) in the tissues of GATA-1(low) mice...
- Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregationHasna Kanta
Department of Biological Sciences, University of Arkansas, Fayetteville 72701, USA
Genetics 173:435-50. 2006..We identified five genes, HHT1, MKS1, HDA1, HDA2, and HDA3, four of which encode proteins directly connected to chromatin function: histone H3 and each ..
- Vitamin K content of foods and dietary vitamin K intake in Japanese young womenMaya Kamao
Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan
J Nutr Sci Vitaminol (Tokyo) 53:464-70. 2007..To obtain a closer estimate of dietary intake of phylloquinone (PK) and menaquinones (MKs), PK, MK-4 and MK-7 contents in food samples (58 food items) were determined by an improved high-performance liquid ..
- Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiationJ J Reiners
Department of Carcinogenesis, University of Texas M D Anderson Cancer Center
Drug Metab Dispos 20:360-6. 1992..and 7-ethoxyresorufin O-deethylase (7-ERD) were measured in four subpopulations of murine epidermal keratinocytes (MKs) that differed in their stages of differentiation...
- Storage pool deficiency in cattle with the Chédiak-Higashi syndrome results from an absence of dense granule precursors in their megakaryocytesM Menard
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164 6520
Blood 72:1726-34. 1988..Megakaryocytes (MKs) from five control (n = 135) and five CHS (n = 133) cattle were evaluated using standard transmission electron ..
- Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptorsJennifer Antonchuk
Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Blood 104:1306-13. 2004..However, the number of megakaryocytic colony forming units (CFU-Mks) was significantly reduced, particularly in the spleen...
- PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)Takafumi Nakao
Department of Medicine, Division of Hematology Oncology, University of California San Diego, La Jolla, California, USA
Cell Cycle 7:257-66. 2008..We found that TPO down-modulates p27(Kip1) expression at both the mRNA and protein levels in primary MKs in a PI3K dependent fashion...
- The suitability of 160Tb as a PAC probe for studies of biomoleculesN P Sidhu
Department of Physics, Punjabi University, Patiala, India
Int J Rad Appl Instrum A 39:437-8. 1988The gamma-ray perturbed angular correlation (PAC) studies were made with 160Tb as a probe in MES (2[N-morpholino]-ethane sulphonic acid) solutions of various concentrations...
- Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HNS P Ridley
Mol Cell Biol 4:761-70. 1984..The dominant mutations in one gene (MKS50) and recessive mutations in at least two genes (mks1 and mks2) suppress M2 exclusion by L-A-HN but do not show other characteristics of ski mutations and thus define a ..
- Mks1p is a regulator of nitrogen catabolism upstream of Ure2p in Saccharomyces cerevisiaeH K Edskes
Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
Genetics 153:585-94. 1999..Overexpression of Mks1p does not affect cellular levels of Ure2p. An mks1 ure2 double mutant can take up ureidosuccinate on either ammonia or proline...
- Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesY Miyakawa
Division of Hematology, University of Washington School of Medicine, Seattle 98195, USA
J Biol Chem 276:2494-502. 2001..Although many downstream signaling targets of TPO have been identified in cell lines, primary MKs, and platelets, the molecular mechanism(s) by which many of these molecules are activated remains uncertain...
- Kinetics of endomitosis in primary murine megakaryocytesC E Carow
Department of Medicine, University of Washington, Seattle 98195 7710, USA
J Cell Physiol 188:291-303. 2001Megakaryocytes (MKs) develop from diploid progenitor cells via successive rounds of DNA synthesis in the absence of cell division, a process termed endomitosis (EnM)...
- Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet releaseGianfranco Mattia
Department of Clinical Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
Blood 99:888-97. 2002..blood (PB) were investigated on their capability to give rise, in a serum-free medium containing thrombopoietin, to MKs and platelets...
- Megakaryocytes require thrombospondin-2 for normal platelet formation and functionThemis R Kyriakides
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Blood 101:3915-23. 2003..Megakaryocytes (MKs) show high levels of TSP2 by immunohistochemical analysis of bone marrow...
- Preferential ex vivo expansion of megakaryocytes from human cord blood CD34+-enriched cells in the presence of thrombopoietin and limiting amounts of stem cell factor and Flt-3 ligandChantal Proulx
Research and Development, HEMA QUEBEC, Canada
J Hematother Stem Cell Res 12:179-88. 2003..of the key factor of megakaryopoiesis, thrombopoietin (TPO), permit the ex vivo expansion of megakaryocytes (MKs) for possible use in early post-transplant support of patients and the production of functional platelets for ..
- Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functionsHarald Schulze
Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
Blood 104:3949-57. 2004..SLPI is expressed in MKs and platelets in 2 discrete compartments...
- Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5Randy O Sigle
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
J Cell Sci 117:4481-94. 2004..5, but not cleaved laminin 5, was bound and deposited by mouse keratinocytes null for mouse alpha3 chain (alpha3-/- MKs). The deposition rescued adhesion and spreading and survival...
- Analysis of microbial community structure in a biofilm on membrane surface in the submerged membrane bioreactor treating domestic wastewater on the basis of respiratory quinone profilesByung Ran Lim
Water Environment and Remediation Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, Seoul, 130 650 Korea
J Gen Appl Microbiol 50:197-202. 2004..on the membrane surface in an intermittently aerated SMBR were ubiquinone (UQs)-8, -10, followed by menaquinones (MKs)-8(H4), -8(H2) and -7, but those of suspended microorganisms were UQ-8, UQ-10 followed by MKs-8, -9(H4) and -6...
- Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartmentSiham Sabri
Institut National de la Santé etde la Recherche Médicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejut, France
Blood 108:134-40. 2006..By electron microscopy, WASp-deficient MKs appeared to have shed platelets ectopically within the bone marrow space...
- A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic miceTarvinder S Dhanjal
Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, United Kingdom
Blood 109:4237-44. 2007During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet ..
- [Role of histamine H(1) and H(2) receptors in the modulation of respiratory rhythmical discharge in medulla oblongata slice preparation of neonatal rats]Ying Qi
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Sheng Li Xue Bao 60:397-402. 2008..hypoglossal nerve rootlets was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O(2) and 5% CO(2)), and ended in 3 min...
- Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1Jin Long Qiu
Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark
Plant Physiol 148:212-22. 2008..the kinases in jasmonate- and salicylate-dependent defense responses, mediated in part via the MPK4 substrate MKS1. In addition, transcriptome analyses delineate overlapping and specific effects of the kinases on global gene ..
- [Glycine is involved in the modulation of respiratory rhythmical discharge activity in neonatal rat medullary brain slices]Jing Cheng
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Nan Fang Yi Ke Da Xue Xue Bao 28:2142-5. 2008..To determine the role of glycine (Gly) in the generation and modulation of basic respiratory rhythm...
- NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood developmentAnnarita Miccio
Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
EMBO J 29:442-56. 2010..Gene expression analysis in primary mutant erythroid cells and megakaryocytes (MKs) revealed an essential function for NuRD during both the repression and activation of select GATA-1/FOG-1 target ..
- Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2BPaquita Nurden
Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
Blood 115:2649-56. 2010..Cultures of MKs from controls performed with or without purified VWF confirmed a positive influence of VWF on platelet production ..
- Novel TMEM67 mutations and genotype-phenotype correlates in meckelin-related ciliopathiesMiriam Iannicelli
Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo and CSS Mendel Institute, Viale Regina Margherita 261, Rome, Italy
Hum Mutat 31:E1319-31. 2010..Among ciliopathies, Joubert syndrome and related disorders (JSRD), Meckel syndrome (MKS) and nephronophthisis (NPH) present clinical and genetic overlap, being allelic at several loci...
- [The Mounier-Kuhn syndrome]Rade Milić
Vojnomedicinska akademija, Klinika za Plucne Bolesti, Beograd, Srbija
Vojnosanit Pregl 67:867-70. 2010The Mounier-Kuhn syndrome (MKS) or tracheobronchomegaly (TBM) is a rare condition of unknown frequency, up to now about 100 cases have been reported...
- Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategyEdgar A Otto
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
J Med Genet 48:105-16. 2011..includes nephronophthisis (NPHP), Senior-Loken syndrome (SLS), Joubert syndrome (JBTS), and Meckel-Gruber syndrome (MKS)...
- Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper functionKlaus Petersen
Department of Biology, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 5:e14364. 2010..MAP kinase 4 (MPK4) functions downstream of innate immune receptors via a nuclear substrate MKS1 to regulate the activity of the WRKY33 transcription factor, which in turn controls the production of anti-..
- Renal cystic disease proteins play critical roles in the organization of the olfactory epitheliumJennifer L Pluznick
Department of Cellular and Molecular Physiology, Yale School of Medicine New Haven, Connecticut, United States of America
PLoS ONE 6:e19694. 2011..proteins associated with renal cystic diseases - polycystin 1 and 2 (PC1, PC2), and Meckel-Gruber syndrome 1 and 3 (MKS1, MKS3) - localize to the murine OE. PC1, PC2, MKS1 and MKS3 are all detected in the OE by RT-PCR...
- FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorlyAntonija Jurak Begonja
Division of Translational Medicine, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA
Blood 118:2285-95. 2011..Analysis of platelet production in vitro reveals that FlnA-null MKs prematurely convert their cytoplasm into large CD61(+) platelet-sized particles, reminiscent of the large platelets ..
- [The effects of thrombopoietin on the fibrogenesis of bone marrow stromal cells in absence of megakaryocytes]Jian Liang Shen
Department of Hematology, Navy General Hospital, Beijing 100048, China
Zhongguo Ying Yong Sheng Li Xue Za Zhi 27:163-6. 2011In order to investigate whether or not thrombopoietin (TPO) could promote the fibrogenesis of bone marrow stromal cells in absence of megakaryocytes (MKs).
- TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zoneLijia Huang
Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Am J Hum Genet 89:713-30. 2011..elegans JBTS-14 and MKS-2/TMEM216, MKSR-1/B9D1, and MKSR-2/B9D2...
- Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartmentDapeng Zhang
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
Cell Cycle 11:3861-75. 2012..of these complexes are at the heart of human ciliopathies such as Nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Bardet-Biedl syndrome (BBS) and Joubert syndrome (JBTS)...
- Cytogenetic abnormalities and monosomal karyotypes in children and adolescents with acute myeloid leukemia: correlations with clinical characteristics and outcomeKalliopi N Manola
Department of Cytogenetics, Laboratory of Health Physics and Enviromental Health, NCSR Demokritos Athens, Greece
Cancer Genet 206:63-72. 2013..Moreover, the incidence and prognostic impact of monosomal karyotypes (MKs), which are new cytogenetic categories reported recently in adults with AML, are currently unknown for childhood ..
- Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndromeGabrielle Wheway
Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, Beckett Street, The University of Leeds, Leeds, LS9 7 TF, UK
Dev Biol 377:55-66. 2013..Mutations in the basal body protein MKS1 account for 7% of cases of MKS...
- Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedsideVarda R Deutsch
The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
Br J Haematol 161:778-93. 2013..proliferation and terminal differentiation of megakaryocytic progenitors (MK-p) and maturation of megakaryocytes (MKs) to produce functional platelets...
- Early abdomino-perineal pull-through vaginoplastyIlhan Ciftci
Department of Pediatric Surgery, Selcuk University, Medical Faculty, Konya, Turkey
Afr J Paediatr Surg 10:188-91. 2013..McKusick-Kaufman syndrome (MKS) is an autosomal recessive multiple malformation syndrome characterized by Müllerian anomalies with ..
- McKusick Kaufman syndrome, complications arising at pubertyErin T Lueth
University of Colorado, Denver, CO
J Pediatr Adolesc Gynecol 27:e125-6. 2014McKusick Kaufman Syndrome (MKS), a rare genetic condition, presents in the neonatal period with a classic triad of postaxial polydactyly, congenital heart disease, and hydrometrocolpos...
- Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytesS Stritt
Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Wurzburg, Wurzburg, Germany
J Thromb Haemost 12:1364-71. 2014Blood platelets are small anucleated cell fragments generated from bone marrow megakaryocytes (MKs) by a cytoskeleton-driven process...
- Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesisSara C Meyer
Human Oncology and Pathogenesis Program
Blood 124:2280-4. 2014..We evaluated the impact of Jak2 deletion in platelets (PLTs) and megakaryocytes (MKs) on blood counts, stem/progenitor cells, and Jak-Stat signaling...
- SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cellsMiguel G Toscano
1 Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer University of Granada Andalusian Regional Government, PTS Granada, Granada, Spain 2 Current address Amarna Therapeutics SL Seville, Spain
Mol Ther 23:158-70. 2015..We show that ectopic SCL expression enhances the emergence of megakaryocytic precursors, mature megakaryocytes (MKs), and platelets in vitro...
- Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet releaseI Badirou
Institut National de la Sante et de la Recherche Medicale, Villejuif, France Université Paris Sud, Le Kremlin Bicetre, France Institut Gustave Roussy, Villejuif, France
J Thromb Haemost 13:851-9. 2015At the end of maturation, megakaryocytes (MKs) form long cytoplasmic extensions called proplatelets (PPT)...
- Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndromeLuigi M Larocca
a Department of Pathology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
Platelets 26:751-7. 2015..In 4/4 patients, the BM biopsy showed fibrosis (grade 2-3) and extensive emperipolesis, with many (36-65%) MKs containing 2-4 leukocytes engulfed within the cytoplasm...
- Repellency and oviposition deterrence of wild tomato leaf extracts to spider mites, Tetranychus urticae KochGeorge F Antonious
a Division of Environmental Studies, College of Agriculture, Food Science, and Sustainable Systems, Kentucky State University, Frankfort, Kentucky, USA
J Environ Sci Health B 50:667-73. 2015..Mull, also known as Solanum habrochaites (Solanaceae) synthesize and accumulate high levels of methyl ketones (MKs)...
- Identification of a novel MKS locus defined by TMEM107 mutationRanad Shaheen
Department of Genetics and
Hum Mol Genet 24:5211-8. 2015Meckel-Gruber syndrome (MKS) is a perinatally lethal disorder characterized by the triad of occipital encephalocele, polydactyly and polycystic kidneys...
- A missense mutation in TMEM67 causes Meckel-Gruber syndrome type 3 (MKS3): a family from ChinaManli Zhang
Department of Obstetrics and Gynecology, Chinese PLA General Hospital Beijing 100853, China
Int J Clin Exp Pathol 8:5379-86. 2015..Genetic heterogeneity has been demonstrated at eleven loci, MKS1-11...
- CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrowAyako Nakamura-Ishizu
Cancer Science Institute, National University of Singapore, Singapore 117599 The Sakaguchi Laboratory, Department of Cell Differentiation, Keio University, Shinjuku ku, Tokyo 160 8582, Japan International Research Center for Medical Sciences IRCMS, Kumamoto University, Chuo Ku, Kumamoto City 860 0811, Japan
J Exp Med 212:2133-46. 2015..The BM niche is composed of nonhematopoietic and mature hematopoietic cells, including megakaryocytes (Mks). Thrombopoietin (Thpo) is a crucial cytokine produced by BM niche cells...
- Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration Via Distinct and Overlapping MechanismsPierre P Eleniste
Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana
J Cell Biochem 117:1396-406. 2016..Megakaryocytes (MKs), the platelet-producing cells, also promote osteoblast proliferation in vitro and bone-formation in vivo via a ..
- Characterization of thrombopoietin kinetics within 60 days after allogeneic hematopoietic stem cell transplantation and its correlation with megakaryocyte ploidy distributionHaixia Fu
Peking University People s Hospital, Institute of Hematology, Beijing, China
Clin Transplant 30:170-8. 2016..We attempt to characterize the kinetics of TPO and its correlation with megakaryocytes (MKs) ploidy distribution pattern within 60 d after allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
- Application of biogenic carbon dioxide produced by yeast with different carbon sources for attraction of mosquitoes towards adult mosquito trapsD Sukumaran
Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, India
Parasitol Res 115:1453-62. 2016..This setup was applied in field condition along with two different mosquito traps namely Mosquito Killing System (MKS) and Biogents Sentinel (BGS) trap. Biogenic CO2 from this setup has increased the trapping efficiency of MKS by 6...
- Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevisYuta Tanizaki
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 2 2 Wakamatsu, Shinjuku, Tokyo, 162 8480, Japan
Sci Rep 5:18519. 2015The development of mammalian megakaryocytes (MKs) and platelets, which are thought to be absent in non-mammals, is primarily regulated by the thrombopoietin (TPO)/Mpl system...
- Linkage between the mechanisms of thrombocytopenia and thrombopoiesisKoji Eto
Department of Clinical Application Research, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan and
Blood 127:1234-41. 2016..is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis)...
- Regulatory role of Megakaryocytes on Hematopoietic Stem Cells Quiescence by CXCL4/PF4 in Bone Marrow NicheFatemeh Norozi
Health Research Institute, Thalassemia and Hemoglobinopathies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Leuk Res 48:107-12. 2016..Megakaryocytes (Mks) are associated with the vascular niche in the bone marrow (BM) and are located in vicinity of BM sinusoids...
- Respiratory Conditions Associated with Tracheobronchomegaly (Mounier-Kuhn Syndrome): A Study of Seventeen CasesPierre Schmitt
Department of Respiratory Medicine, University Hospital Maison Blanche, Reims, France
Respiration 91:281-7. 2016Mounier-Kuhn syndrome (MKS) is a rare disorder characterized by enlargement of the trachea and main bronchi and associated with recurrent respiratory tract infections.
- Cellular and Molecular Regulation of ThrombopoiesisRamesh A Shivdasani; Fiscal Year: 2012..Cellular and molecular mechanisms of platelet assembly within, and their release from, megakaryocytes (MKs) remain largely unknown...
- Martha C Sola-Visner; Fiscal Year: 2015..not understood, but are clearly related to the unique biological characteristics of fetal/neonatal megakaryocytes (MKs)...
- 2013 Cell Biology of Megakaryocytes and Platelets GRC &GRSKatya Ravid; Fiscal Year: 2013..Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them...
- Louis M Pelus; Fiscal Year: 2016..have forged a new collaboration based upon the findings in the Kacena laboratory of a novel role of megakaryocytes (MKs) produced by the hematopoietic system in stimulating bone formation by osteoblasts (OBs);findings in the Pelus ..
- Melissa A Kacena; Fiscal Year: 2015DESCRIPTION (provided by applicant): A growing body of evidence suggests that megakaryocytes (MKs) play a key role in regulating skeletal homeostasis...
- Role of shear forces in proplatelet production from stem cells in bioreactorsEleftherios T Papoutsakis; Fiscal Year: 2012DESCRIPTION (provided by applicant): Megakaryocytes (Mks) are derived from hematopoietic stem cells...
- MKL in megakaryocytopoiesisDiane S Krause; Fiscal Year: 2013..during megakaryocytic differentiation with the highest levels in the most mature polyploid megakaryocytes (Mks), 2) overexpression of wildtype (WT) MKL1 promotes Mk differentiation of human cell lines as well as primary murine ..
- Stress and Platelet NPY in Vascular RemodelingJohn W Osborn; Fiscal Year: 2012..MK turnover and up-regulation of NPY expression in MK/platelets, mediated by sympathetic, NPY-ergic activation of MKs. The hypothesis that platelet NPY, at certain threshold concentrations, triggers the inflammatory cascade was ..
- Katya Ravid; Fiscal Year: 2015DESCRIPTION (provided by applicant): Megakaryocytes (MKs) are responsible for the production of platelets, which have a major impact on blood homeostasis...
- LISA MADALEN NISWANDER; Fiscal Year: 2015..stromal-derived factor-1 (SDF-1), signaling through receptor CXCR4, has been implicated in the chemotaxis of MKs toward sinusoidal vessels, however we lack a comprehensive analysis of SDF-1/CXCR4 signaling in MK lineage ..
- CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPEShahin Rafii; Fiscal Year: 2002..It is hypothesized that disruption of chemokine network, and adhesive interactions between megakaryocytes (MKs) and bone marrow endothelium (BMEC) as it may occur during HIV infection, plays a seminal role in the failure of MK ..
- David L Kaplan; Fiscal Year: 2015..to build upon our recent successful studies where a novel bioreactor system was engineered to house megakaryocytes (Mks) and to generate functional platelets in vitro...
- JONATHAN NOAH THON; Fiscal Year: 2014..b>MKs release long branched extensions called proPLTs into sinusoidal blood vessels that undergo repeated abcissions to ..
- GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESISKenneth Kaushansky; Fiscal Year: 2006..the role of survivin, INCENP and Aurora kinases, and the integrity of the late anaphase checkpoint in polyploid MKs. Finally, as we recently participated in the cloning and initial characterization of a new cytokine, a fourth ..
- Peter C Harris; Fiscal Year: 2016..we will study two apparently recessively inherited PKDs, autosomal recessive PKD (ARPKD) and Meckel syndrome (MKS)...
- Jinghua Hu; Fiscal Year: 2016..ADPKD), Joubert syndrome (JBST), Bardet-Biedl syndrome (BBS), nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), and autosomal recessive polycystic kidney disease (ARPKD), have been characterized molecularly as cilia-related ..
- Abnormal Megakaryocyte DevelopmentDIANA GILLIGAN; Fiscal Year: 2006..a "systems biology" approach will be applied to study and interpret the molecular fingerprint of abnormal MKs and platelets from these pedigrees in comparison to normal individuals...
- Maureen M Barr; Fiscal Year: 2014..kidney disease (ADPKD), autosomal recessive PKD, Bardet-Biedl Syndrome (BBS), and Meckel Gruber Syndrome (MKS)...
- Jarema Malicki; Fiscal Year: 2014..Many forms of human blindness involve cilia malfunction. Nephronophthisis (NPHP) and Meckel-Gruber syndrome (MKS) are ciliary disorders that in addition to other abnormalities involve photoreceptor degeneration and blindness...
- Bioengineering challenges for platelet production from hematopoietic stem cellsWilliam M Miller; Fiscal Year: 2010..Production of autologous or compatible platelets by megakaryocytic cells (Mks) derived from cultured hematopoietic stem and progenitor cells (HSPCs or CD34+ cells) would greatly decrease these ..
- ERICA ELLEN DAVIS; Fiscal Year: 2015..In RPGRIP1L, a gene known to cause neonatal lethal Meckel-Gruber Syndrome (MKS) and moderately severe Joubert Syndrome (JBTS), we identified a highly-conserved A229T change which was present at ..
- Bradley K Yoder; Fiscal Year: 2016..These include Nephronophthisis (NPHP) and Meckel Syndrome (MKS)...
- Novel Wnt effectors in renal cystic diseaseErica Davis; Fiscal Year: 2009..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
- CONTROL INTERFACE ASSESSMENT SYSTEMCindy George; Fiscal Year: 1991..microcomputers and utilize two specially designed control interface devices: a Membrane Keyboard Simulator (MKS) and a Universal Adjustable Microswitch (UAS)...
- Thrombopoietin Signaling: The Role of Src KinasesBRIAN LANNUTTI; Fiscal Year: 2007..Understanding the signaling mechanisms of Mp1 and its interactions with other signaling molecules may lead to novel approaches in the treatment of a number of hematologic and other diseases. ..
- THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALINGAmy Geddis; Fiscal Year: 2005..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..
- CHEMOSENSORY TRANSDUCTIONJUDITH VAN HOUTEN; Fiscal Year: 2003..These studies should inform the research of others who study sensory transduction in olfaction, taste, chemotaxis and other signaling stems. ..
- Aberrant Platelet Mechanisms in Inherited Human Platelet Function DisordersANGARA KONETI RAO; Fiscal Year: 2010..Our studies will provide a wealth of information on platelet mechanisms and on potential new targets for antithrombotic therapy. ..
- SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETSA Rao; Fiscal Year: 2006..Overall, our studies will provide new important insights into the regulation of two key platelet proteins (G-alpha-q and PLC-beta2) involved in platelet signaling and into the signaling mechanisms in platelets. ..
- Plasma Membrane Ca-ATPases in Mouse Chemosensory CellsJUDITH VAN HOUTEN; Fiscal Year: 2005..The understanding of OSN and VSN function is important for understanding normal olfactory and VNO function in health and disease. ..
- MECHANISMS REGULATING ENDOMITOSIS IN MEGAKARYOCYTESKatya Ravid; Fiscal Year: 2001..3) To determine the roles of MegNIMA-like, NIMA kinases and CD3 in megakaryocytopoiesis and thrombocytopoiesis in cultured cells and in vivo. The in vitro studies will be done with both rat megakaryocytes and with cell lines. ..
- BAYLOR BIRCWH PROGRAMJoe Simpson; Fiscal Year: 2004..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
- GPI ANCHORED PROTEINS IN CHEMORESPONSEJUDITH VAN HOUTEN; Fiscal Year: 2004..abstract_text> ..