MKS1

Summary

Gene Symbol: MKS1
Description: Meckel syndrome, type 1
Alias: BBS13, JBTS28, MES, MKS, POC12, Meckel syndrome type 1 protein, POC12 centriolar protein homolog
Species: human

Top Publications

  1. ncbi Periodic limb movement disorder is associated with normal motor conduction latencies when studied by central magnetic stimulation--successful use of a new technique
    R C Smith
    Department of Medicine, Michigan State University, East Lansing 48824
    Sleep 15:312-8. 1992
  2. ncbi Extracellular matrix receptors and the differentiation of human megakaryocytes in vitro
    A Molla
    , UMR CNRS UJF 5538, Institut Albert Bonniot, La Tronche, France
    Leuk Lymphoma 33:15-23. 1999
  3. ncbi Meckel syndrome in the Hutterite population is actually a Joubert-related cerebello-oculo-renal syndrome
    Kym M Boycott
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet A 143:1715-25. 2007
  4. doi Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Nature 468:117-21. 2010
  5. pmc Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
    Nathan J Bialas
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    J Cell Sci 122:611-24. 2009
  6. ncbi MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome
    Mira Kyttälä
    Department of Molecular Medicine, National Public Health Institute, FI 00251 Helsinki, Finland
    Nat Genet 38:155-7. 2006
  7. ncbi Molecular diagnostics of Meckel-Gruber syndrome highlights phenotypic differences between MKS1 and MKS3
    Mark B Consugar
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Hum Genet 121:591-9. 2007
  8. ncbi Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. Online
    Rana Khaddour
    INSERM U 781, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
    Hum Mutat 28:523-4. 2007
  9. ncbi A disease causing deletion of 29 base pairs in intron 15 in the MKS1 gene is highly associated with the campomelic variant of the Meckel-Gruber syndrome
    B Auber
    Institute of Human Genetics, University of Goettingen, Germany
    Clin Genet 72:454-9. 2007
  10. doi Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
    Carmen C Leitch
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
    Nat Genet 40:443-8. 2008

Research Grants

  1. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
  2. Martha C Sola-Visner; Fiscal Year: 2015
  3. 2013 Cell Biology of Megakaryocytes and Platelets GRC &GRS
    Katya Ravid; Fiscal Year: 2013
  4. Louis M Pelus; Fiscal Year: 2016
  5. Melissa A Kacena; Fiscal Year: 2015
  6. Role of shear forces in proplatelet production from stem cells in bioreactors
    Eleftherios T Papoutsakis; Fiscal Year: 2012
  7. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2013
  8. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
  9. Katya Ravid; Fiscal Year: 2015
  10. LISA MADALEN NISWANDER; Fiscal Year: 2015

Detail Information

Publications177 found, 100 shown here

  1. ncbi Periodic limb movement disorder is associated with normal motor conduction latencies when studied by central magnetic stimulation--successful use of a new technique
    R C Smith
    Department of Medicine, Michigan State University, East Lansing 48824
    Sleep 15:312-8. 1992
    ..Subjects had no other medical or sleep problems. A novel magnetic stimulator, the Cadwell MES-10, was discharged over the vertex and the C7 cervical spine...
  2. ncbi Extracellular matrix receptors and the differentiation of human megakaryocytes in vitro
    A Molla
    , UMR CNRS UJF 5538, Institut Albert Bonniot, La Tronche, France
    Leuk Lymphoma 33:15-23. 1999
    ..of extracellular matrix receptors (or integrins) in the course of the differentiation of human megakaryocytes (Mks) leading to the formation of platelets...
  3. ncbi Meckel syndrome in the Hutterite population is actually a Joubert-related cerebello-oculo-renal syndrome
    Kym M Boycott
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet A 143:1715-25. 2007
    Meckel syndrome (MKS) is a rare lethal autosomal recessive disorder characterized by the presence of occipital encephalocele, cystic kidneys, fibrotic changes of the liver and polydactyly...
  4. doi Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Nature 468:117-21. 2010
    ..the natural world in several forms, including a plant form, phylloquinone (PK), and a bacterial form, menaquinones (MKs)...
  5. pmc Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
    Nathan J Bialas
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    J Cell Sci 122:611-24. 2009
    ..An identifying feature of MKS1, one of six MKS-associated proteins, is the presence of a B9 domain of unknown function...
  6. ncbi MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome
    Mira Kyttälä
    Department of Molecular Medicine, National Public Health Institute, FI 00251 Helsinki, Finland
    Nat Genet 38:155-7. 2006
    ..Here we report the identification of a gene, MKS1, mutated in MKS families linked to 17q...
  7. ncbi Molecular diagnostics of Meckel-Gruber syndrome highlights phenotypic differences between MKS1 and MKS3
    Mark B Consugar
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Hum Genet 121:591-9. 2007
    ..MKS is genetically heterogeneous with three loci mapped and two identified; MKS1 (17q23) and MKS3 (8q22.1)...
  8. ncbi Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. Online
    Rana Khaddour
    INSERM U 781, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
    Hum Mutat 28:523-4. 2007
    ..MKS is genetically heterogeneous and three loci have been mapped respectively on 17q23 (MKS1), 11q13 (MKS2), and 8q24 (MKS3)...
  9. ncbi A disease causing deletion of 29 base pairs in intron 15 in the MKS1 gene is highly associated with the campomelic variant of the Meckel-Gruber syndrome
    B Auber
    Institute of Human Genetics, University of Goettingen, Germany
    Clin Genet 72:454-9. 2007
    ..Recently, mutations in the MKS1 gene have been identified as disease causing in individuals of Finnish MKS families...
  10. doi Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
    Carmen C Leitch
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
    Nat Genet 40:443-8. 2008
    ..Here we show that mutations in MKS1, MKS3 and CEP290 (also known as NPHP6) either can cause Bardet-Biedl syndrome (BBS) or may have a potential ..
  11. ncbi Displacement chromatography of proteins using a self-sharpening pH front formed by adsorbed buffering species as the displacer
    C R Narahari
    Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore 21250, USA
    J Chromatogr A 825:115-26. 1998
    ..of acetic acid and either 3-(N-morpholino)propane-sulfonic acid (MOPS) or 2-(N-morpholino)ethanesulfonic acid (MES). Sample loads up to 150 mg of protein were applied to a 75 x 7...
  12. ncbi Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensation
    L F Zhang
    Department of Aviation Environmental Physiology, Fourth Military Medical College, Xi an
    Sci Sin B 31:204-16. 1988
    ..A new kind of category scale, the multistage evaluation scale (MES), based on a fuzzy set category judgement model for quantifying respiratory sensory magnitude has been put forward ..
  13. pmc Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 113:1349-57. 1994
    ..The threshold for maximal (tonic) electroshock seizures (MES) was significantly increased by GYKI 52466 (10-20 mg kg-1), NBQX (80-120 mg kg-1) and diazepam (5 mg kg-1) shortly ..
  14. ncbi Trace determination of iron in water at the microgram/l level by on-line coupling of capillary isotachophoresis and capillary zone electrophoresis with UV detection of the EDTA-Fe (III) complex
    P Blatný
    Department of Carbohydrate Chemistry and Technology, Institute of Chemical Technology, Prague, Czech Republic
    J Chromatogr A 757:297-302. 1997
    ..1% hydroxypropylmethyl cellulose (pH 6.0), 5 mmol/l MES, and 25 mmol/l MES + 10 mmol/l bis-tris-propane (pH 6...
  15. doi Combination of cor triatriatum sinistrum and hypoplastic left heart syndrome in Meckel-Gruber syndrome: a case report
    Mana Taweevisit
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, 1873 King Rama IV Street, Pathumwan, Bangkok, Thailand
    Pediatr Dev Pathol 12:404-9. 2009
    Meckel-Gruber syndrome (MKS) is a fatal, autosomal recessive disorder characterized by malformation of central nervous system, particularly occipital encephalocele, bilateral renal dysplasia, and polydactyly...
  16. pmc The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome
    Lekbir Baala
    INSERM U 781, Hopital Necker Enfants Malades, Paris, France
    Am J Hum Genet 80:186-94. 2007
    ..obvious phenotypic overlap between JS and MKS, we hypothesized that mutations in the recently identified MKS genes, MKS1 on chromosome 17q and MKS3 on 8q, may be a cause of JS...
  17. ncbi The anticonvulsant activities of N-benzyl 3-methoxypropionamides
    S V Andurkar
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    Bioorg Med Chem 7:2381-9. 1999
    We recently reported that the ED50 value for (R,S)-2,3-dimethoxypropionamide (1) in the maximal electroshock (MES)-induced seizure test in mice was 30 mg/kg (Choi, D.; Stables, J.P., Kohn, H. Bioorg. Med. Chem. 1996, 4, 2105)...
  18. ncbi Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome
    Melissa A Fath
    Department of Pediatrics, Division of Medcal Genetics, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 14:1109-18. 2005
    McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia...
  19. pmc Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
    Cheng Cui
    University of Pittsburgh, Department of Developmental Biology, 8111 Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201, USA
    Dis Model Mech 4:43-56. 2011
    ..We recovered a mouse mutant with a mutation in the Mks1 gene (Mks1(del64-323)) that caused a 260-amino-acid deletion spanning nine amino acids in the B9 domain, a protein ..
  20. pmc The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation
    Wendy A Ciovacco
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA
    Bone 44:80-6. 2009
    ..Recently, we reported that megakaryocytes (MKs) enhance osteoblast (OB) proliferation by a juxtacrine signaling mechanism...
  21. ncbi Mutations in MKKS cause Bardet-Biedl syndrome
    A M Slavotinek
    Genetic Diseases Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Nat Genet 26:15-6. 2000
    ..Some BBS cases (approximately 10%) remain unassigned to the five previously mapped loci. McKusick-Kaufma syndrome (MKS) includes hydrometrocolpos, postaxial polydactyly and congenital heart disease, and is also inherited in an ..
  22. ncbi Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome
    Valeska Frank
    Department of Human Genetics, RWTH Aachen University, Aachen, Germany
    Hum Mutat 29:45-52. 2008
    ..Recently, genes for MKS1 and MKS3 were identified, putting MKS on the list of ciliary disorders (ciliopathies)...
  23. ncbi Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1(low) mice: a possible role in osteosclerosis
    Rama Garimella
    University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Histochem Cytochem 55:745-52. 2007
    ..However, growth factors released from the bone marrow cells, including from MKs, have been implicated in myelofibrosis, osteosclerosis, and angiogenesis...
  24. ncbi Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
    ..vitamin K compounds comprise a plant form, phylloquinone (vitamin K(1)) and a series of bacterial menaquinones (MKs) (vitamin K(2))...
  25. ncbi [5-HT(1A) receptors are involved in the modulation of respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats]
    Zheng Qin
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 59:293-8. 2007
    ..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O2 and 5% CO2), and ended in 3 min...
  26. ncbi Megakaryocytes and platelets in experimentally induced renovascular hypertension (2K1C) in rats
    Joanna Pawlak
    Department of Human Anatomy, Medical University of Białystok
    Postepy Hig Med Dosw (Online) 62:241-8. 2008
    ..Approximately 10% of the population with hypertension reveals the secondary type of the disease. The aim of the study was to evaluate the megakaryocyte-platelet system in the course of renovascular hypertension...
  27. ncbi [D(1)-dopamine receptor is involved in the modulation of the respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats in vitro.]
    Yong gang Jiao
    Department of Physiology, Southern Medical University, Guangzhou, China
    Sheng Li Xue Bao 60:704-8. 2008
    ..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous ventilating 95% O2 and 5% CO2 and ended in 3 min...
  28. pmc Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes
    José P Young
    Dept of Physiology and Biophysics, Georgetown Univ, Columbia, Washington, DC 20057, USA
    Am J Physiol Cell Physiol 298:C602-10. 2010
    ..in a fluctuating fashion, triggering oscillatory outward Ca(2+)-activated K(+) currents in rat megakaryocytes (MKs)...
  29. ncbi Long-term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin-amplified in clinical grade serum-free culture
    Gianfranco Mattia
    Department of Hematology, Oncology and Molecular Medicine, Section of Transfusion Methodologies, Istituto Superiore di Sanita, Rome, Italy
    Exp Hematol 36:244-52. 2008
    ..when induced to differentiate along the megakaryocytic (MK) lineage, retention of a low ploidy in the expanded MKs. Ex vivo expansion of CB hematopoietic progenitor cells for reconstitution of different human hematopoietic ..
  30. ncbi [Effect of glial cell metabolism on respiratory rhythmical discharge activity in neonatal rat medulla oblongata slices]
    Fang Fang
    Department of Physiology, Southern Medical University, Guangdong, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2410-3. 2009
    ..To explore the role of glial cell metabolism in the generation and regulation of central respiratory rhythm...
  31. ncbi The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
    Koji Eto
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Japan
    Blood 110:3637-47. 2007
    ..While MKs and platelets principally express WAVE1 and WAVE2, which are associated with Abi1, the physiologic significance of ..
  32. pmc Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle
    Jonna Tallila
    National Public Health Institute, Institute for Molecular Medicine Finland, Helsinki 00290, Finland
    Am J Hum Genet 82:1361-7. 2008
    Meckel syndrome (MKS) is a lethal malformation disorder characterized classically by encephalocele, polycystic kidneys, and polydactyly. MKS is also one of the major contributors to syndromic neural tube defects (NTDs)...
  33. doi Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling
    Larissa Lordier
    INSERM, U790, Villejuif, France
    Blood 112:3164-74. 2008
    ..No abnormality was observed in the central spindle of endomitotic MKs. A furrow formation was present, but the contractile ring was abnormal because accumulation of nonmuscle myosin IIA ..
  34. ncbi Prenatal diagnosis of the Meckel-Gruber syndrome from 11th to 20th gestational week
    C Mittermayer
    Department of Neonatology and Intensive Care, University Hospital Vienna
    Ultraschall Med 25:275-9. 2004
    The Meckel-Gruber syndrome (MKS) is a rare autosomal recessive disorder that is characterized by typical sonographical findings: occipital encephalocele, postaxial polydactyly and cystic enlargement of the kidneys...
  35. ncbi Microembolic signals and clinical outcome in patients with acute stroke--a prospective study
    A Delcker
    Department of Neurology, University of Essen, Germany
    Eur Arch Psychiatry Clin Neurosci 250:1-5. 2000
    The occurrence of microembolic signals (MES) in patients with transient ischemic attack (TIA) or stroke has already been described; the influence of the time interval between onset of symptoms and transcranial Doppler monitoring (TCD) on ..
  36. ncbi Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 27:397-401. 2000
    ..b>MKs were identified morphologically, and the bone marrow cell population and MK number quantified by cell counting in a ..
  37. ncbi Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:455-60. 2007
    ..We have postulated that anaphase in endomitotic MKs diverges from diploid mitosis at a point distal to the assembly of the midzone, possibly involving impaired ..
  38. ncbi CD41+/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocytic population in murine bone marrow
    Kuniko Matsumura-Takeda
    Molecular Medical Science Institute, Otsuka Pharmaceutical Co Ltd, 463 10 Kagasuno, Tokushima, Japan
    Stem Cells 25:862-70. 2007
    Murine megakaryocytes (MKs) are defined by CD41/CD61 expression and acetylcholinesterase (AChE) activity; however, their stages of differentiation in bone marrow (BM) have not been fully elucidated...
  39. ncbi New perspectives on keratoconus as revealed by corneal confocal microscopy
    Nathan Efron
    Institute of Health and Biomedical Innovation and School of Optometry, Queensland University of Technology, Brisbane, Australia
    Clin Exp Optom 91:34-55. 2008
    Confocal microscopy (CM) of keratoconus is reviewed. In the Manchester Keratoconus Study (MKS), slit scanning CM was used to evaluate 29 keratoconic patients and light microscopy (LM) was performed on two of the keratoconic corneas post-..
  40. ncbi [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]
    Zhi bin Qian
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:216-20. 2008
    ..DOI), and an antagonist of 5-HT(2A) receptor, ketanserine, dissolved in modified Krebos solution (MKS)...
  41. pmc Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    Donald J McCrann
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 114:1243-9. 2009
    Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy...
  42. pmc Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4
    Corey L Williams
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA
    J Am Soc Nephrol 21:782-93. 2010
    ..to renal cyst formation in multiple human syndromes including nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Joubert syndrome (JBTS), and Bardet-Beidl syndrome (BBS)...
  43. ncbi [Effect of doxapram on the respiratory rhythmical discharge activity in the brainstem slice of neonatal rats]
    Guo cai Li
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:245-8. 2010
    ..To investigate the effects of doxapram on the respiratory rhythmical discharge activity (RRDA) in the brainstem slices of neonatal rats...
  44. ncbi The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
    P Rojnuckarin
    Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 276:41014-22. 2001
    ..ERK/mitogen-activated protein kinase pathway is important for TPO-induced endomitosis in primary megakaryocytes (MKs)...
  45. ncbi Classical Swine Fever: pathology of bone marrow
    J C Gomez-Villamandos
    Departamento Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Cordoba, Spain
    Vet Pathol 40:157-63. 2003
    ..Megakaryocytes (MKs) did not show significant changes in number, but there were important qualitative changes including 1) increased ..
  46. ncbi Identification and activation of Src family kinases in primary megakaryocytes
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
    Exp Hematol 31:1268-74. 2003
    ..In this study, we examine which of the eight Src family members are expressed in primary megakaryocytes (MKs) and determine which of these become activated in response to TPO.
  47. ncbi Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    Lucia Centurione
    Department of Biomorphology, University G D Annunzio, Chieti, Italy
    Blood 104:3573-80. 2004
    ..blocks megakaryocytic maturation between stage I and II, resulting in accumulation of defective megakaryocytes (MKs) in the tissues of GATA-1(low) mice...
  48. pmc Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation
    Hasna Kanta
    Department of Biological Sciences, University of Arkansas, Fayetteville 72701, USA
    Genetics 173:435-50. 2006
    ..We identified five genes, HHT1, MKS1, HDA1, HDA2, and HDA3, four of which encode proteins directly connected to chromatin function: histone H3 and each ..
  49. ncbi Vitamin K content of foods and dietary vitamin K intake in Japanese young women
    Maya Kamao
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:464-70. 2007
    ..To obtain a closer estimate of dietary intake of phylloquinone (PK) and menaquinones (MKs), PK, MK-4 and MK-7 contents in food samples (58 food items) were determined by an improved high-performance liquid ..
  50. ncbi Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation
    J J Reiners
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center
    Drug Metab Dispos 20:360-6. 1992
    ..and 7-ethoxyresorufin O-deethylase (7-ERD) were measured in four subpopulations of murine epidermal keratinocytes (MKs) that differed in their stages of differentiation...
  51. ncbi Storage pool deficiency in cattle with the Chédiak-Higashi syndrome results from an absence of dense granule precursors in their megakaryocytes
    M Menard
    Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164 6520
    Blood 72:1726-34. 1988
    ..Megakaryocytes (MKs) from five control (n = 135) and five CHS (n = 133) cattle were evaluated using standard transmission electron ..
  52. ncbi Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors
    Jennifer Antonchuk
    Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 104:1306-13. 2004
    ..However, the number of megakaryocytic colony forming units (CFU-Mks) was significantly reduced, particularly in the spleen...
  53. ncbi PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)
    Takafumi Nakao
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, La Jolla, California, USA
    Cell Cycle 7:257-66. 2008
    ..We found that TPO down-modulates p27(Kip1) expression at both the mRNA and protein levels in primary MKs in a PI3K dependent fashion...
  54. ncbi The suitability of 160Tb as a PAC probe for studies of biomolecules
    N P Sidhu
    Department of Physics, Punjabi University, Patiala, India
    Int J Rad Appl Instrum A 39:437-8. 1988
    The gamma-ray perturbed angular correlation (PAC) studies were made with 160Tb as a probe in MES (2[N-morpholino]-ethane sulphonic acid) solutions of various concentrations...
  55. pmc Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN
    S P Ridley
    Mol Cell Biol 4:761-70. 1984
    ..The dominant mutations in one gene (MKS50) and recessive mutations in at least two genes (mks1 and mks2) suppress M2 exclusion by L-A-HN but do not show other characteristics of ski mutations and thus define a ..
  56. pmc Mks1p is a regulator of nitrogen catabolism upstream of Ure2p in Saccharomyces cerevisiae
    H K Edskes
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Genetics 153:585-94. 1999
    ..Overexpression of Mks1p does not affect cellular levels of Ure2p. An mks1 ure2 double mutant can take up ureidosuccinate on either ammonia or proline...
  57. ncbi Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
    Y Miyakawa
    Division of Hematology, University of Washington School of Medicine, Seattle 98195, USA
    J Biol Chem 276:2494-502. 2001
    ..Although many downstream signaling targets of TPO have been identified in cell lines, primary MKs, and platelets, the molecular mechanism(s) by which many of these molecules are activated remains uncertain...
  58. ncbi Kinetics of endomitosis in primary murine megakaryocytes
    C E Carow
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    J Cell Physiol 188:291-303. 2001
    Megakaryocytes (MKs) develop from diploid progenitor cells via successive rounds of DNA synthesis in the absence of cell division, a process termed endomitosis (EnM)...
  59. ncbi Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release
    Gianfranco Mattia
    Department of Clinical Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Blood 99:888-97. 2002
    ..blood (PB) were investigated on their capability to give rise, in a serum-free medium containing thrombopoietin, to MKs and platelets...
  60. ncbi Megakaryocytes require thrombospondin-2 for normal platelet formation and function
    Themis R Kyriakides
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Blood 101:3915-23. 2003
    ..Megakaryocytes (MKs) show high levels of TSP2 by immunohistochemical analysis of bone marrow...
  61. ncbi Preferential ex vivo expansion of megakaryocytes from human cord blood CD34+-enriched cells in the presence of thrombopoietin and limiting amounts of stem cell factor and Flt-3 ligand
    Chantal Proulx
    Research and Development, HEMA QUEBEC, Canada
    J Hematother Stem Cell Res 12:179-88. 2003
    ..of the key factor of megakaryopoiesis, thrombopoietin (TPO), permit the ex vivo expansion of megakaryocytes (MKs) for possible use in early post-transplant support of patients and the production of functional platelets for ..
  62. ncbi Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
    Harald Schulze
    Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Blood 104:3949-57. 2004
    ..SLPI is expressed in MKs and platelets in 2 discrete compartments...
  63. ncbi Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5
    Randy O Sigle
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
    J Cell Sci 117:4481-94. 2004
    ..5, but not cleaved laminin 5, was bound and deposited by mouse keratinocytes null for mouse alpha3 chain (alpha3-/- MKs). The deposition rescued adhesion and spreading and survival...
  64. ncbi Analysis of microbial community structure in a biofilm on membrane surface in the submerged membrane bioreactor treating domestic wastewater on the basis of respiratory quinone profiles
    Byung Ran Lim
    Water Environment and Remediation Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, Seoul, 130 650 Korea
    J Gen Appl Microbiol 50:197-202. 2004
    ..on the membrane surface in an intermittently aerated SMBR were ubiquinone (UQs)-8, -10, followed by menaquinones (MKs)-8(H4), -8(H2) and -7, but those of suspended microorganisms were UQ-8, UQ-10 followed by MKs-8, -9(H4) and -6...
  65. ncbi Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment
    Siham Sabri
    Institut National de la Santé etde la Recherche Médicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejut, France
    Blood 108:134-40. 2006
    ..By electron microscopy, WASp-deficient MKs appeared to have shed platelets ectopically within the bone marrow space...
  66. ncbi A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice
    Tarvinder S Dhanjal
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, United Kingdom
    Blood 109:4237-44. 2007
    During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet ..
  67. ncbi [Role of histamine H(1) and H(2) receptors in the modulation of respiratory rhythmical discharge in medulla oblongata slice preparation of neonatal rats]
    Ying Qi
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:397-402. 2008
    ..hypoglossal nerve rootlets was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O(2) and 5% CO(2)), and ended in 3 min...
  68. pmc Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1
    Jin Long Qiu
    Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark
    Plant Physiol 148:212-22. 2008
    ..the kinases in jasmonate- and salicylate-dependent defense responses, mediated in part via the MPK4 substrate MKS1. In addition, transcriptome analyses delineate overlapping and specific effects of the kinases on global gene ..
  69. ncbi [Glycine is involved in the modulation of respiratory rhythmical discharge activity in neonatal rat medullary brain slices]
    Jing Cheng
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:2142-5. 2008
    ..To determine the role of glycine (Gly) in the generation and modulation of basic respiratory rhythm...
  70. pmc NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development
    Annarita Miccio
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    EMBO J 29:442-56. 2010
    ..Gene expression analysis in primary mutant erythroid cells and megakaryocytes (MKs) revealed an essential function for NuRD during both the repression and activation of select GATA-1/FOG-1 target ..
  71. doi Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B
    Paquita Nurden
    Centre de Reference des Pathologies Plaquettaires, Plateforme Technologique et d Innovation Biomedicale, Hopital Xavier Arnozan, Pessac, France
    Blood 115:2649-56. 2010
    ..Cultures of MKs from controls performed with or without purified VWF confirmed a positive influence of VWF on platelet production ..
  72. pmc Novel TMEM67 mutations and genotype-phenotype correlates in meckelin-related ciliopathies
    Miriam Iannicelli
    Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo and CSS Mendel Institute, Viale Regina Margherita 261, Rome, Italy
    Hum Mutat 31:E1319-31. 2010
    ..Among ciliopathies, Joubert syndrome and related disorders (JSRD), Meckel syndrome (MKS) and nephronophthisis (NPH) present clinical and genetic overlap, being allelic at several loci...
  73. ncbi [The Mounier-Kuhn syndrome]
    Rade Milić
    Vojnomedicinska akademija, Klinika za Plucne Bolesti, Beograd, Srbija
    Vojnosanit Pregl 67:867-70. 2010
    The Mounier-Kuhn syndrome (MKS) or tracheobronchomegaly (TBM) is a rare condition of unknown frequency, up to now about 100 cases have been reported...
  74. pmc Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy
    Edgar A Otto
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    J Med Genet 48:105-16. 2011
    ..includes nephronophthisis (NPHP), Senior-Loken syndrome (SLS), Joubert syndrome (JBTS), and Meckel-Gruber syndrome (MKS)...
  75. pmc Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function
    Klaus Petersen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e14364. 2010
    ..MAP kinase 4 (MPK4) functions downstream of innate immune receptors via a nuclear substrate MKS1 to regulate the activity of the WRKY33 transcription factor, which in turn controls the production of anti-..
  76. pmc Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium
    Jennifer L Pluznick
    Department of Cellular and Molecular Physiology, Yale School of Medicine New Haven, Connecticut, United States of America
    PLoS ONE 6:e19694. 2011
    ..proteins associated with renal cystic diseases - polycystin 1 and 2 (PC1, PC2), and Meckel-Gruber syndrome 1 and 3 (MKS1, MKS3) - localize to the murine OE. PC1, PC2, MKS1 and MKS3 are all detected in the OE by RT-PCR...
  77. pmc FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly
    Antonija Jurak Begonja
    Division of Translational Medicine, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 118:2285-95. 2011
    ..Analysis of platelet production in vitro reveals that FlnA-null MKs prematurely convert their cytoplasm into large CD61(+) platelet-sized particles, reminiscent of the large platelets ..
  78. ncbi [The effects of thrombopoietin on the fibrogenesis of bone marrow stromal cells in absence of megakaryocytes]
    Jian Liang Shen
    Department of Hematology, Navy General Hospital, Beijing 100048, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 27:163-6. 2011
    In order to investigate whether or not thrombopoietin (TPO) could promote the fibrogenesis of bone marrow stromal cells in absence of megakaryocytes (MKs).
  79. pmc TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone
    Lijia Huang
    Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Am J Hum Genet 89:713-30. 2011
    ..elegans JBTS-14 and MKS-2/TMEM216, MKSR-1/B9D1, and MKSR-2/B9D2...
  80. pmc Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment
    Dapeng Zhang
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 11:3861-75. 2012
    ..of these complexes are at the heart of human ciliopathies such as Nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Bardet-Biedl syndrome (BBS) and Joubert syndrome (JBTS)...
  81. doi Cytogenetic abnormalities and monosomal karyotypes in children and adolescents with acute myeloid leukemia: correlations with clinical characteristics and outcome
    Kalliopi N Manola
    Department of Cytogenetics, Laboratory of Health Physics and Enviromental Health, NCSR Demokritos Athens, Greece
    Cancer Genet 206:63-72. 2013
    ..Moreover, the incidence and prognostic impact of monosomal karyotypes (MKs), which are new cytogenetic categories reported recently in adults with AML, are currently unknown for childhood ..
  82. doi Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome
    Gabrielle Wheway
    Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, Beckett Street, The University of Leeds, Leeds, LS9 7 TF, UK
    Dev Biol 377:55-66. 2013
    ..Mutations in the basal body protein MKS1 account for 7% of cases of MKS...
  83. doi Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside
    Varda R Deutsch
    The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Br J Haematol 161:778-93. 2013
    ..proliferation and terminal differentiation of megakaryocytic progenitors (MK-p) and maturation of megakaryocytes (MKs) to produce functional platelets...
  84. doi Early abdomino-perineal pull-through vaginoplasty
    Ilhan Ciftci
    Department of Pediatric Surgery, Selcuk University, Medical Faculty, Konya, Turkey
    Afr J Paediatr Surg 10:188-91. 2013
    ..McKusick-Kaufman syndrome (MKS) is an autosomal recessive multiple malformation syndrome characterized by Müllerian anomalies with ..
  85. doi McKusick Kaufman syndrome, complications arising at puberty
    Erin T Lueth
    University of Colorado, Denver, CO
    J Pediatr Adolesc Gynecol 27:e125-6. 2014
    McKusick Kaufman Syndrome (MKS), a rare genetic condition, presents in the neonatal period with a classic triad of postaxial polydactyly, congenital heart disease, and hydrometrocolpos...
  86. doi Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes
    S Stritt
    Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Wurzburg, Wurzburg, Germany
    J Thromb Haemost 12:1364-71. 2014
    Blood platelets are small anucleated cell fragments generated from bone marrow megakaryocytes (MKs) by a cytoskeleton-driven process...
  87. pmc Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis
    Sara C Meyer
    Human Oncology and Pathogenesis Program
    Blood 124:2280-4. 2014
    ..We evaluated the impact of Jak2 deletion in platelets (PLTs) and megakaryocytes (MKs) on blood counts, stem/progenitor cells, and Jak-Stat signaling...
  88. pmc SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells
    Miguel G Toscano
    1 Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer University of Granada Andalusian Regional Government, PTS Granada, Granada, Spain 2 Current address Amarna Therapeutics SL Seville, Spain
    Mol Ther 23:158-70. 2015
    ..We show that ectopic SCL expression enhances the emergence of megakaryocytic precursors, mature megakaryocytes (MKs), and platelets in vitro...
  89. doi Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release
    I Badirou
    Institut National de la Sante et de la Recherche Medicale, Villejuif, France Université Paris Sud, Le Kremlin Bicetre, France Institut Gustave Roussy, Villejuif, France
    J Thromb Haemost 13:851-9. 2015
    At the end of maturation, megakaryocytes (MKs) form long cytoplasmic extensions called proplatelets (PPT)...
  90. doi Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndrome
    Luigi M Larocca
    a Department of Pathology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    Platelets 26:751-7. 2015
    ..In 4/4 patients, the BM biopsy showed fibrosis (grade 2-3) and extensive emperipolesis, with many (36-65%) MKs containing 2-4 leukocytes engulfed within the cytoplasm...
  91. doi Repellency and oviposition deterrence of wild tomato leaf extracts to spider mites, Tetranychus urticae Koch
    George F Antonious
    a Division of Environmental Studies, College of Agriculture, Food Science, and Sustainable Systems, Kentucky State University, Frankfort, Kentucky, USA
    J Environ Sci Health B 50:667-73. 2015
    ..Mull, also known as Solanum habrochaites (Solanaceae) synthesize and accumulate high levels of methyl ketones (MKs)...
  92. doi Identification of a novel MKS locus defined by TMEM107 mutation
    Ranad Shaheen
    Department of Genetics and
    Hum Mol Genet 24:5211-8. 2015
    Meckel-Gruber syndrome (MKS) is a perinatally lethal disorder characterized by the triad of occipital encephalocele, polydactyly and polycystic kidneys...
  93. pmc A missense mutation in TMEM67 causes Meckel-Gruber syndrome type 3 (MKS3): a family from China
    Manli Zhang
    Department of Obstetrics and Gynecology, Chinese PLA General Hospital Beijing 100853, China
    Int J Clin Exp Pathol 8:5379-86. 2015
    ..Genetic heterogeneity has been demonstrated at eleven loci, MKS1-11...
  94. pmc CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow
    Ayako Nakamura-Ishizu
    Cancer Science Institute, National University of Singapore, Singapore 117599 The Sakaguchi Laboratory, Department of Cell Differentiation, Keio University, Shinjuku ku, Tokyo 160 8582, Japan International Research Center for Medical Sciences IRCMS, Kumamoto University, Chuo Ku, Kumamoto City 860 0811, Japan
    J Exp Med 212:2133-46. 2015
    ..The BM niche is composed of nonhematopoietic and mature hematopoietic cells, including megakaryocytes (Mks). Thrombopoietin (Thpo) is a crucial cytokine produced by BM niche cells...
  95. pmc Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration Via Distinct and Overlapping Mechanisms
    Pierre P Eleniste
    Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana
    J Cell Biochem 117:1396-406. 2016
    ..Megakaryocytes (MKs), the platelet-producing cells, also promote osteoblast proliferation in vitro and bone-formation in vivo via a ..
  96. doi Characterization of thrombopoietin kinetics within 60 days after allogeneic hematopoietic stem cell transplantation and its correlation with megakaryocyte ploidy distribution
    Haixia Fu
    Peking University People s Hospital, Institute of Hematology, Beijing, China
    Clin Transplant 30:170-8. 2016
    ..We attempt to characterize the kinetics of TPO and its correlation with megakaryocytes (MKs) ploidy distribution pattern within 60 d after allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
  97. doi Application of biogenic carbon dioxide produced by yeast with different carbon sources for attraction of mosquitoes towards adult mosquito traps
    D Sukumaran
    Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, India
    Parasitol Res 115:1453-62. 2016
    ..This setup was applied in field condition along with two different mosquito traps namely Mosquito Killing System (MKS) and Biogents Sentinel (BGS) trap. Biogenic CO2 from this setup has increased the trapping efficiency of MKS by 6...
  98. pmc Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis
    Yuta Tanizaki
    Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 2 2 Wakamatsu, Shinjuku, Tokyo, 162 8480, Japan
    Sci Rep 5:18519. 2015
    The development of mammalian megakaryocytes (MKs) and platelets, which are thought to be absent in non-mammals, is primarily regulated by the thrombopoietin (TPO)/Mpl system...
  99. pmc Linkage between the mechanisms of thrombocytopenia and thrombopoiesis
    Koji Eto
    Department of Clinical Application Research, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan and
    Blood 127:1234-41. 2016
    ..is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis)...
  100. doi Regulatory role of Megakaryocytes on Hematopoietic Stem Cells Quiescence by CXCL4/PF4 in Bone Marrow Niche
    Fatemeh Norozi
    Health Research Institute, Thalassemia and Hemoglobinopathies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
    Leuk Res 48:107-12. 2016
    ..Megakaryocytes (Mks) are associated with the vascular niche in the bone marrow (BM) and are located in vicinity of BM sinusoids...
  101. doi Respiratory Conditions Associated with Tracheobronchomegaly (Mounier-Kuhn Syndrome): A Study of Seventeen Cases
    Pierre Schmitt
    Department of Respiratory Medicine, University Hospital Maison Blanche, Reims, France
    Respiration 91:281-7. 2016
    Mounier-Kuhn syndrome (MKS) is a rare disorder characterized by enlargement of the trachea and main bronchi and associated with recurrent respiratory tract infections.

Research Grants34

  1. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..Cellular and molecular mechanisms of platelet assembly within, and their release from, megakaryocytes (MKs) remain largely unknown...
  2. Martha C Sola-Visner; Fiscal Year: 2015
    ..not understood, but are clearly related to the unique biological characteristics of fetal/neonatal megakaryocytes (MKs)...
  3. 2013 Cell Biology of Megakaryocytes and Platelets GRC &GRS
    Katya Ravid; Fiscal Year: 2013
    ..Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them...
  4. Louis M Pelus; Fiscal Year: 2016
    ..have forged a new collaboration based upon the findings in the Kacena laboratory of a novel role of megakaryocytes (MKs) produced by the hematopoietic system in stimulating bone formation by osteoblasts (OBs);findings in the Pelus ..
  5. Melissa A Kacena; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): A growing body of evidence suggests that megakaryocytes (MKs) play a key role in regulating skeletal homeostasis...
  6. Role of shear forces in proplatelet production from stem cells in bioreactors
    Eleftherios T Papoutsakis; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Megakaryocytes (Mks) are derived from hematopoietic stem cells...
  7. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2013
    ..during megakaryocytic differentiation with the highest levels in the most mature polyploid megakaryocytes (Mks), 2) overexpression of wildtype (WT) MKL1 promotes Mk differentiation of human cell lines as well as primary murine ..
  8. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
    ..MK turnover and up-regulation of NPY expression in MK/platelets, mediated by sympathetic, NPY-ergic activation of MKs. The hypothesis that platelet NPY, at certain threshold concentrations, triggers the inflammatory cascade was ..
  9. Katya Ravid; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Megakaryocytes (MKs) are responsible for the production of platelets, which have a major impact on blood homeostasis...
  10. LISA MADALEN NISWANDER; Fiscal Year: 2015
    ..stromal-derived factor-1 (SDF-1), signaling through receptor CXCR4, has been implicated in the chemotaxis of MKs toward sinusoidal vessels, however we lack a comprehensive analysis of SDF-1/CXCR4 signaling in MK lineage ..
  11. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..It is hypothesized that disruption of chemokine network, and adhesive interactions between megakaryocytes (MKs) and bone marrow endothelium (BMEC) as it may occur during HIV infection, plays a seminal role in the failure of MK ..
  12. David L Kaplan; Fiscal Year: 2015
    ..to build upon our recent successful studies where a novel bioreactor system was engineered to house megakaryocytes (Mks) and to generate functional platelets in vitro...
  13. JONATHAN NOAH THON; Fiscal Year: 2014
    ..b>MKs release long branched extensions called proPLTs into sinusoidal blood vessels that undergo repeated abcissions to ..
  14. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
    ..the role of survivin, INCENP and Aurora kinases, and the integrity of the late anaphase checkpoint in polyploid MKs. Finally, as we recently participated in the cloning and initial characterization of a new cytokine, a fourth ..
  15. Peter C Harris; Fiscal Year: 2016
    ..we will study two apparently recessively inherited PKDs, autosomal recessive PKD (ARPKD) and Meckel syndrome (MKS)...
  16. Jinghua Hu; Fiscal Year: 2016
    ..ADPKD), Joubert syndrome (JBST), Bardet-Biedl syndrome (BBS), nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), and autosomal recessive polycystic kidney disease (ARPKD), have been characterized molecularly as cilia-related ..
  17. Abnormal Megakaryocyte Development
    DIANA GILLIGAN; Fiscal Year: 2006
    ..a "systems biology" approach will be applied to study and interpret the molecular fingerprint of abnormal MKs and platelets from these pedigrees in comparison to normal individuals...
  18. Maureen M Barr; Fiscal Year: 2014
    ..kidney disease (ADPKD), autosomal recessive PKD, Bardet-Biedl Syndrome (BBS), and Meckel Gruber Syndrome (MKS)...
  19. Jarema Malicki; Fiscal Year: 2014
    ..Many forms of human blindness involve cilia malfunction. Nephronophthisis (NPHP) and Meckel-Gruber syndrome (MKS) are ciliary disorders that in addition to other abnormalities involve photoreceptor degeneration and blindness...
  20. Bioengineering challenges for platelet production from hematopoietic stem cells
    William M Miller; Fiscal Year: 2010
    ..Production of autologous or compatible platelets by megakaryocytic cells (Mks) derived from cultured hematopoietic stem and progenitor cells (HSPCs or CD34+ cells) would greatly decrease these ..
  21. ERICA ELLEN DAVIS; Fiscal Year: 2015
    ..In RPGRIP1L, a gene known to cause neonatal lethal Meckel-Gruber Syndrome (MKS) and moderately severe Joubert Syndrome (JBTS), we identified a highly-conserved A229T change which was present at ..
  22. Bradley K Yoder; Fiscal Year: 2016
    ..These include Nephronophthisis (NPHP) and Meckel Syndrome (MKS)...
  23. Novel Wnt effectors in renal cystic disease
    Erica Davis; Fiscal Year: 2009
    ..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
  24. CONTROL INTERFACE ASSESSMENT SYSTEM
    Cindy George; Fiscal Year: 1991
    ..microcomputers and utilize two specially designed control interface devices: a Membrane Keyboard Simulator (MKS) and a Universal Adjustable Microswitch (UAS)...
  25. Thrombopoietin Signaling: The Role of Src Kinases
    BRIAN LANNUTTI; Fiscal Year: 2007
    ..Understanding the signaling mechanisms of Mp1 and its interactions with other signaling molecules may lead to novel approaches in the treatment of a number of hematologic and other diseases. ..
  26. THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALING
    Amy Geddis; Fiscal Year: 2005
    ..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..
  27. CHEMOSENSORY TRANSDUCTION
    JUDITH VAN HOUTEN; Fiscal Year: 2003
    ..These studies should inform the research of others who study sensory transduction in olfaction, taste, chemotaxis and other signaling stems. ..
  28. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..Our studies will provide a wealth of information on platelet mechanisms and on potential new targets for antithrombotic therapy. ..
  29. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006
    ..Overall, our studies will provide new important insights into the regulation of two key platelet proteins (G-alpha-q and PLC-beta2) involved in platelet signaling and into the signaling mechanisms in platelets. ..
  30. Plasma Membrane Ca-ATPases in Mouse Chemosensory Cells
    JUDITH VAN HOUTEN; Fiscal Year: 2005
    ..The understanding of OSN and VSN function is important for understanding normal olfactory and VNO function in health and disease. ..
  31. MECHANISMS REGULATING ENDOMITOSIS IN MEGAKARYOCYTES
    Katya Ravid; Fiscal Year: 2001
    ..3) To determine the roles of MegNIMA-like, NIMA kinases and CD3 in megakaryocytopoiesis and thrombocytopoiesis in cultured cells and in vivo. The in vitro studies will be done with both rat megakaryocytes and with cell lines. ..
  32. BAYLOR BIRCWH PROGRAM
    Joe Simpson; Fiscal Year: 2004
    ..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
  33. GPI ANCHORED PROTEINS IN CHEMORESPONSE
    JUDITH VAN HOUTEN; Fiscal Year: 2004
    ..abstract_text> ..