MIR9-1

Summary

Gene Symbol: MIR9-1
Description: microRNA 9-1
Alias: MIRN9-1, hsa-mir-9-1, miRNA9-1
Species: human

Top Publications

  1. pmc miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
    Himanshu Arora
    Laboratory of Molecular and Genomic Medicine, Department of Biomedical Sciences, Seoul National University College of Medicine, Korea
    Exp Mol Med 43:298-304. 2011
  2. pmc Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
  3. doi MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer
    Jae Moon Gwak
    Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Breast Cancer Res Treat 147:39-49. 2014
  4. doi Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma
    Angela B Y Hui
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 19:2154-62. 2013
  5. pmc MicroRNA-9 as potential biomarker for breast cancer local recurrence and tumor estrogen receptor status
    Xin Zhou
    Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    PLoS ONE 7:e39011. 2012
  6. pmc Aberrant hypermethylation of miR-9 genes in gastric cancer
    Kuo Wang Tsai
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China
    Epigenetics 6:1189-97. 2011
  7. pmc Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer
    Kengo Shigehara
    Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    PLoS ONE 6:e23584. 2011
  8. doi MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility
    Liang Zhu
    Cancer Institute Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Med Oncol 29:1037-43. 2012
  9. doi Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma
    M A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:5724-8. 2010
  10. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010

Scientific Experts

  • Eun Jung Jin
  • Zong hui Wu
  • G Pignot
  • Da Jun Deng
  • Anna Torres
  • Xavier Nissan
  • R Krishnan Kutty
  • Xiaoling Wu
  • Eniko Sonkoly
  • Yan Li
  • Weijun Liu
  • Xiaoxia Hu
  • Hongchun Luo
  • Li Min Guo
  • Hong Yu Gao
  • Jun Deng
  • Irina V Pronina
  • Chu hai Xie
  • Jiangbo Zhang
  • Chen Tian
  • K Nowek
  • Aaron Topol
  • Ling Hu
  • Prince Jeyabal
  • Eryong Lu
  • Young Ran Park
  • Myriam Ben Dhiab
  • Shao Wen Zhu
  • Haifeng Wang
  • Jing Jing Li
  • Dalong Xie
  • Adriana Sondermann
  • Mingchen Zhu
  • Chao pan Zheng
  • Ana O'Loghlen
  • Samira Mohammadi-Yeganeh
  • Xi Chen
  • Qi Zhang
  • Zhi Xin Zhang
  • T Yu
  • Ye Song
  • Wei Liu
  • Michela Visani
  • Jae Moon Gwak
  • Shi hong Xu
  • Li Ting Wang
  • Fei Gao
  • Jinsoo Song
  • Yuwen Song
  • Haosha Tang
  • Maryam Hafizi
  • ZhiJun Zhang
  • Angela B Y Hui
  • Liang Zhu
  • Julie K Schwarz
  • Guanglei Zhuang
  • Xin Zhou
  • Perry W Grigsby
  • Xiaochao Tan
  • Xiaowei Wang
  • Yantao Du
  • Fen Biao Gao
  • Pichayanoot Rotkrua
  • Kengo Shigehara
  • Feng Li
  • Kuo Wang Tsai
  • Himanshu Arora
  • Hai Ying Wan
  • M A T Hildebrandt
  • Celine Delaloy
  • Bin Yin
  • Antonio Sacco
  • Li Ma
  • Xiaomin Zhong
  • Hua Tang
  • Xin Li
  • Tao Liu
  • Min Liu
  • Flavia Bazzoni
  • Teng fei Chao
  • Hai Yan Wang
  • Dong Sheng Pei
  • Fu Chun Huo
  • K van Lom
  • In Hee Kim
  • H Dohner
  • Shijia Zhu
  • Yu Chuan Liu
  • Min Ro Lee
  • Lijun Zhao

Detail Information

Publications68

  1. pmc miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
    Himanshu Arora
    Laboratory of Molecular and Genomic Medicine, Department of Biomedical Sciences, Seoul National University College of Medicine, Korea
    Exp Mol Med 43:298-304. 2011
    ..From these results, we conclude that the expression of miR-9 and let-7g could enhance the efficiency of radiotherapy for lung cancer treatment through the inhibition of NFκB1...
  2. pmc Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
    ....
  3. doi MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer
    Jae Moon Gwak
    Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Breast Cancer Res Treat 147:39-49. 2014
    ....
  4. doi Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma
    Angela B Y Hui
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 19:2154-62. 2013
    ..Hence, the objectives of this study were to determine whether miRNA expression differed as a function of HPV status and to assess whether such miRNAs provide prognostic value beyond HPV status...
  5. pmc MicroRNA-9 as potential biomarker for breast cancer local recurrence and tumor estrogen receptor status
    Xin Zhou
    Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    PLoS ONE 7:e39011. 2012
    ..02). Expression levels of miR-9 and another miR candidate, miR-375, were also strongly associated with ER status (p<0.001 for both). The potential of miR-9 as a biomarker for LR warrants further investigation with larger sample size...
  6. pmc Aberrant hypermethylation of miR-9 genes in gastric cancer
    Kuo Wang Tsai
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China
    Epigenetics 6:1189-97. 2011
    ..Ectopic expression of miR-9 inhibited cell proliferation, migration and invasion, suggesting its tumor suppressive potential in gastric cancer progression...
  7. pmc Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer
    Kengo Shigehara
    Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    PLoS ONE 6:e23584. 2011
    ..These findings suggest that bile miRNAs could be informative biomarkers for hepatobiliary disease and that some miRNAs, particularly miR-9, may be helpful in the diagnosis and clinical management of BTC...
  8. doi MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility
    Liang Zhu
    Cancer Institute Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Med Oncol 29:1037-43. 2012
    ..The overexpression of miR-9 could also down-regulate α-catenin expression. These data suggest that miR-9 may potentially participate in the metastatic process of CRC though facilitating cell motility...
  9. doi Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma
    M A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:5724-8. 2010
    ..034 and 0.007 for miR-9-1 and miR-9-3, respectively). Our results demonstrate that hsa-miR-9 is involved in the development of ccRCC while also having a role in the development of metastatic recurrence...
  10. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010
    ..These findings uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis-suppressing protein E-cadherin...
  11. pmc Down-regulated miR-9 and miR-433 in human gastric carcinoma
    Hongchun Luo
    Department of Gastroenterology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China
    J Exp Clin Cancer Res 28:82. 2009
    ..MircoRNAs(miRNAs) are short, endogenously non-coding RNAs. The abnormal expression of miRNAs may be valuable for the diagnosis and treatment of tumors...
  12. doi MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1
    Li Min Guo
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, China
    FEBS J 276:5537-46. 2009
    ....
  13. ncbi [MiR-9 regulates the expression of CBX7 in human glioma]
    Teng fei Chao
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30:268-74. 2008
    ..To detect the expression of CBX7 in human glioma and investigate the potential regulatory effect of abnormally expressed microRNAs on CBX7 expression...
  14. pmc Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma
    Hai Ying Wan
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin 300070, PR China
    Mol Cancer 9:16. 2010
    ....
  15. pmc A microRNA expression signature for cervical cancer prognosis
    Xiaoxia Hu
    Departments of Radiation Oncology, Pathology and Immunology, and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:1441-8. 2010
    ..In particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordinate suppression of multiple genes controlling cell motility...
  16. pmc MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors
    Celine Delaloy
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, CA 94158, USA
    Cell Stem Cell 6:323-35. 2010
    ..These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs...
  17. doi MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
    Jing Jing Li
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, Australia
    J Allergy Clin Immunol 136:462-73. 2015
    ..MicroRNAs (miRs) are small noncoding RNAs that regulate the function of innate immune cells by controlling mRNA stability and translation. Their role in regulating glucocorticoid responsiveness and AHR remains unexplored...
  18. doi Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell
    Jiangbo Zhang
    Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P R China
    Mol Carcinog 55:732-42. 2016
    ..In conclusion, our results here present a tumor suppressor potential of miR-9 in cervical adenocarcinoma for the first time and suggest that miR-9 could repress tumorigenesis through inhibiting the activity of IL-6/Jak/STAT3 pathway...
  19. doi MicroRNA-9 inhibits the gastric cancer cell proliferation by targeting TNFAIP8
    Hong Yu Gao
    Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, Xuzhou, China
    Cell Prolif . 2017
    ..However, till now, the relationship between MicroRNA-9 and TNFAIP8 in GC has not been reported...
  20. pmc Up-regulation of miR-9 target CBX7 to regulate invasion ability of bladder transitional cell carcinoma
    Dalong Xie
    Department of Anatomy, College of Basic Medicine, China Medical University, Shenyang, Liaoning, China mainland
    Med Sci Monit 21:225-30. 2015
    ..The objective of this study was to investigate whether the miR-9 can regulate the invasion ability of human bladder transitional cell carcinoma cells by down-regulation of CBX7...
  21. doi Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma
    Qi Zhang
    Department of Haematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou Medical College, Xuzhou, Jiangsu Province, China
    J Clin Pathol 68:557-61. 2015
    ..The miR-9 family microRNAs (miRNAs) are tumour suppressor miRNAs implicated in carcinogenesis. We postulated that miR-9-1, miR-9-2 and miR-9-3 may be inactivated by aberrant promoter methylation in multiple myeloma (MM)...
  22. doi MicroRNA-9 suppresses the sensitivity of CNE2 cells to ultraviolet radiation
    Chao pan Zheng
    Department of Otorhinolaryngology, The First Affiliated Hospital and Otorhinolaryngology Institute, Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Mol Med Rep 12:2367-73. 2015
    ..These findings suggest that miR-9 may be a potential target for modulating the radiosensitivity of NPC cells...
  23. pmc Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis
    Mingchen Zhu
    Department of Clinical Laboratory, Jiangsu Cancer Hospital and Nanjing Medical University Cancer Hospital, Nanjing, China
    Cancer Sci 106:833-9. 2015
    ..Collectively, our results offer in vitro validation of the concept that miR-9 could repress the expression of UHRF1, and function as a tumor-suppressive microRNA in CRC. It may serve as a prognostic and therapeutic marker for CRC. ..
  24. doi Targeting of miR9/NOTCH1 interaction reduces metastatic behavior in triple-negative breast cancer
    Samira Mohammadi-Yeganeh
    Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, 6th Floor, 2th SBUMS Bldg, Next to Ayatollah Taleghani Hospital, Velenjak, Tehran, 198396 3113, Iran
    Chem Biol Drug Des 86:1185-91. 2015
    ..These results shows that miR-9, by direct targeting of NOTCH1, can reveal a suppressor-like activity in metastatic breast cancer cells. ..
  25. doi MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer
    Adriana Sondermann
    Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, Av Albert Einstein, 627, Sao Paulo, SP, 05652 000, Brazil
    Clin Exp Metastasis 32:521-30. 2015
    ..In conclusion, our results support the potential clinical value of miR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid carcinoma...
  26. ncbi miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor
    Shao Wen Zhu
    Tianjin Medical University, Tianjin, China E mail
    Asian Pac J Cancer Prev 16:4509-13. 2015
    ..In sum, these results highlight the importance of miR-9 as an oncogene in regulating the proliferation of osteosarcoma by directly targeting GCIP and may provide new insights into the pathogenesis of osteosarcoma. ..
  27. doi miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer
    Haifeng Wang
    Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming, 650101, China
    Tumour Biol 36:9631-40. 2015
    ..In conclusion, these results indicate that miR-9 upregulation might be associated with malignant phenotype of bladder cancer. miR-9 promotes chemoresistance of bladder cancer cells by target LASS2...
  28. doi Aberrant expression of miR-9/9* in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG
    K Nowek
    Department of Hematology, Erasmus University Medical Center Cancer Institute, Rotterdam, The Netherlands
    Leukemia 30:229-37. 2016
    ..Taken together, this study demonstrates that miR-9/9* are aberrantly expressed in most of AML cases and interfere with normal neutrophil differentiation by downregulation of ERG. ..
  29. doi BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1
    Zhi Xin Zhang
    Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining 272029, China
    Biochem Biophys Res Commun 465:225-31. 2015
    ..However, its molecular mechanism underlying gastric cancer is still unknown. In present study, we investigated whether BANCR was involved in the development of gastric cancer cells via regulation of NF-κB1...
  30. doi Investigation of miR9-1, miR9-2 and miR9-3 Methylation in Hodgkin Lymphoma
    Myriam Ben Dhiab
    Department of Pathology, Farhat Hached University Hospital, Sousse, Tunisia
    Pathobiology 82:195-202. 2015
    ..miR9 is an important tumor suppressor microRNA regulated by DNA methylation in various types of cancers...
  31. pmc CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a)
    Ana O'Loghlen
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, W12 0NN, UK
    Aging Cell 14:1113-21. 2015
    ..The ability of the miR-9 family to regulate senescence could have implications for understanding the role of miR-9 in cancer and aging...
  32. doi Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers
    Irina V Pronina
    Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
    Gene 576:483-91. 2016
    ..01), and GeneCards data) in the examined gynecological tumors...
  33. pmc Oncogenic miR-9 is a target of erlotinib in NSCLCs
    Xi Chen
    Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, China, 210029
    Sci Rep 5:17031. 2015
    ..Clarifying the regulation of miRNAs by erlotinib may indicate novel strategies for enhancing EGFR-targeted cancer therapy. ..
  34. doi MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1
    Chen Tian
    Department of Hematology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, People s Republic of China
    Tumour Biol 37:7461-71. 2016
    ..Our results indicate that the miR-9 plays an important role in supporting AML cell growth and survival by downregulation of Hes1 and that miR-9 has potential as a therapeutic target for treating AML. ..
  35. pmc Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway
    Jun Deng
    Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China
    Oncotarget 7:10037-50. 2016
    ..Taken together, our findings demonstrate that perturbations to miR-9/137-CUL4A-Hippo signaling contribute to gastric tumorigenesis, and suggest potential therapeutic targets for the future treatment of GC. ..
  36. pmc Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer
    Ling Hu
    Department of Anesthesiology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China
    Oncotarget 7:8441-54. 2016
    ..Therefore, we conduct to systematically identify miRNAs related to NSCLC, and their target genes expression changes using microarray data sets...
  37. pmc MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1
    Prince Jeyabal
    Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA
    Biochem Biophys Res Commun 471:423-9. 2016
    ..Taken together our study highlights the potential therapeutic implications of targeting miR-9/ELAVL1 in preventing cardiomyocyte cell loss during HF in diabetics. ..
  38. doi MicroRNA-9 suppresses cell migration and invasion through downregulation of TM4SF1 in colorectal cancer
    Young Ran Park
    Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Int J Oncol 48:2135-43. 2016
    ..Our results also indicate that miR-9 might be a novel target for the treatment of CRC invasion and metastasis. ..
  39. pmc Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
    Aaron Topol
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA
    Cell Rep 15:1024-36. 2016
    ..Together, these data indicate that aberrant levels and activity of miR-9 may be one of the many factors that contribute to SZ risk, at least in a subset of patients. ..
  40. ncbi Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression
    Chu hai Xie
    Department of Orthopedics, The Second Affiliated Hospital of Guangzhou Medical University, No 250 Chang gang dong Road, Guangzhou, 510260, China
    Tumour Biol 37:15031-15041. 2016
    ..These findings may contribute to the lncRNA-targeted therapy for human osteosarcoma...
  41. doi Enhanced miR-9 promotes laryngocarcinoma cell survival via down-regulating PTEN
    Eryong Lu
    Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang, 471003, China
    Biomed Pharmacother 84:608-613. 2016
    ..PTEN expression was down-regulated in the laryngocarcinoma cells with miR-9 overexpression. We also found that miR-9 expression was negatively associated with PTEN expression in laryngocarcinoma tissues...
  42. pmc Activation of miR-9 by human papillomavirus in cervical cancer
    Weijun Liu
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri
    Oncotarget 5:11620-30. 2014
    ..Thus, our work helps to understand the molecular mechanisms as well as identify potential therapeutic targets for cervical cancer and other HPV-induced cancers. ..
  43. pmc MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma
    Ye Song
    State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat sen University Cancer Center, Guangzhou, 510060, China
    Oncotarget 5:11669-80. 2014
    ..Our study also suggests miR-9 can be served as a new independent prognostic marker and/or as a novel potential therapeutic target for ESCC. ..
  44. doi miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1
    Haosha Tang
    Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P R China
    Int J Mol Med 32:381-8. 2013
    ..Moreover, the activation of the TLN1-modulated FAK/AKT pathway was inhibited by the increased miR-9 levels. These results suggest that miR-9 plays a role as a tumor suppressor in OSC by suppressing TLN1 expression...
  45. pmc MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin
    Jinsoo Song
    Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk 570 749, South Korea
    Cell Commun Signal 11:66. 2013
    ..Using these cells, we analyzed the changes in the expression of genes and proteins, tested the expression level of miR-9, and applied a target validation system. We also performed functional study of miR-9 and PRTG...
  46. doi MicroRNA-9 inhibits vasculogenic mimicry of glioma cell lines by suppressing Stathmin expression
    Yuwen Song
    Department of Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, No 37, Yiyuan Street, Harbin, 150001, People s Republic of China
    J Neurooncol 115:381-90. 2013
    ..MicroRNA-9 and its targets may represent a novel panel of molecules for the development of glioma treatment...
  47. doi MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway
    T Yu
    Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, Chengdu, People s Republic of China
    Oncogene 33:5017-27. 2014
    ..These results provide new evidence of miR-9 as a promising tumor gene therapeutic target for OSCC patients. ..
  48. pmc Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations
    ZhiJun Zhang
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e76055. 2013
    ..These results show that iPSC models of FTD/ALS are useful for revealing stress-dependent cellular defects of human patient neurons containing rare TDP-43 mutations in their native genetic contexts. ..
  49. doi Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III
    Michela Visani
    Department of Pharmacy and Biotechnology, FaBiT, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Mol Oncol 8:417-30. 2014
    ..This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. ..
  50. doi Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy
    Li Ting Wang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 30:229-34. 2014
    ..These results clearly suggested that cellular SMN proteins regulated miR-9 expression and that miR-9 expression was related to SMA severity. Thus, miR-9 may be a marker for SMA prognosis. ..
  51. pmc MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma
    Shi hong Xu
    Department of Ultrasound Diagnosis, Shandong Medical Imaging Research Institute, Shandong University, 324 Jingwu Road, Jinan, Shandong Province 250021, China
    World J Surg Oncol 12:195. 2014
    ....
  52. doi Epigenetic silencing of miRNA-9 is correlated with promoter-proximal CpG island hypermethylation in gastric cancer in vitro and in vivo
    Yan Li
    Chongqing Cancer Institute, Chongqing 400030, P R China
    Int J Oncol 45:2576-86. 2014
    ..miR-19b and miR-433 were positively correlated with male gender. Of four candidate miRNAs downregulated in GC, miR-9 is epigenetically regulated by DNA methylation both in vitro and in vivo...
  53. ncbi [Expression of miR-9 in B lymphocytes and B cell lymphomas cell lines and its significance]
    Feng Li
    Department of Pathology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou 510515, China
    Zhonghua Xue Ye Xue Za Zhi 32:249-53. 2011
    ..To investigate the expression of miR-9 in B lymphocytes, B cell lymphoma and classical Hodgkin's lymphoma (cHL) cell lines and its significance...
  54. doi Epigenetics in Waldenström's macroglobulinemia
    Antonio Sacco
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Epigenomics 2:691-6. 2010
    ..In this study it has been demonstrated that WM patients present with a specific miRNA signature. Among deregulated miRNAs, miR-155 and miR-9* play a pivotal role in the pathogenesis of this disease...
  55. doi microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer
    Géraldine Pignot
    Department of Urology, Hopital Cochin, AP HP, Paris F 75014, France
    Int J Cancer 132:2479-91. 2013
    ..05). Our results suggested a promising individual prognostic value of these new markers...
  56. pmc Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
    Yantao Du
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Division of Cancer Etiology, Peking University Cancer Hospital and Institute, Fu Cheng Lu, NO, 52 Haidian District, Beijing 100142, China
    BMC Cancer 12:249. 2012
    ..The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR CpG islands and its relationship with miRNA expression...
  57. pmc Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
    Guanglei Zhuang
    Genentech Inc, South San Francisco, CA 94080, USA
    EMBO J 31:3513-23. 2012
    ..Collectively, these observations suggest that tumour-secreted miRNAs participate in intercellular communication and function as a novel pro-angiogenic mechanism...
  58. doi Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA
    Xavier Nissan
    CECS, I STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    Cell Rep 2:1-9. 2012
    ..Our results support the hypothesis, recently proposed from analyses in mice, that protection of neural cells from progerin accumulation in HGPS is due to the physiologically restricted expression of miR-9 to that cell lineage...
  59. doi Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients
    Anna Torres
    Laboratory of Biostructure, Department of Human Anatomy, Medical University of Lublin, Lublin, Poland
    Int J Cancer 132:1633-45. 2013
    ..909 (95% CI: 0.789-973) and 0.913 (95% CI: 0.794-0.976), respectively. We conclude that miRNA signatures hold a great promise to become noninvasive biomarkers for early EEC detection and prognosis...
  60. doi MicroRNAs as markers for neurally committed CD133+/CD34+ stem cells derived from human umbilical cord blood
    Maryam Hafizi
    Stem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran
    Biochem Genet 51:175-88. 2013
    ..These data highlight the prominent therapeutic potential of hematopoietic stem cells for use in cell therapy of neurodegenerative diseases...
  61. pmc The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells
    Xiaochao Tan
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 7:e49570. 2012
    ....
  62. doi miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells
    Fei Gao
    Cancer Research Institute, Southern Medical University, Guangzhou 510515, PR China
    Biochem Biophys Res Commun 431:610-6. 2013
    ....
  63. doi MiR-9 downregulates CDX2 expression in gastric cancer cells
    Pichayanoot Rotkrua
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 129:2611-20. 2011
    ..004). Therefore, miR-9 might repress CDX2 expression via the binding site in the 3'-UTR, resulting in the promotion of cell proliferation in GCs...
  64. pmc Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells
    Xiaomin Zhong
    Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:41961-71. 2010
    ..Global down-regulation of these miRNAs may be one of the mechanisms of LIN28 reactivation in human cancers...
  65. pmc MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, Bldg 6, Room 112, National Eye Institute, National Institutes of Health, 6 Center Dr, MSC 0608, Bethesda, MD 20892, USA
    Mol Vis 16:1475-86. 2010
    ..The aim of the present study was to investigate the expression of miR-9 in ARPE-19 cells in response to 4HPR treatment, and to identify other miRNAs normally expressed in these cells...
  66. doi microRNAs in inflammation
    Eniko Sonkoly
    Molecular Dermatology Research Group, Unit of Dermatology and Venerology, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Int Rev Immunol 28:535-61. 2009
    ..In this review, we summarize the current knowledge about miRNAs in immunity and inflammation, focusing on the recent results on miRNAs involved in the regulation of immune responses and inflammatory diseases...