Genomes and Genes

Species

MIR33B

Summary

Gene Symbol: MIR33B
Description: microRNA 33b
Alias: MIRN33B, hsa-mir-33b
Species: human

Top Publications

  1. pmc MicroRNA 33 regulates glucose metabolism
    Cristina M Ramírez
    Department of Medicine, Leon H Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 33:2891-902. 2013
  2. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
  3. doi Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels
    Weilie Ma
    Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan, Guangdong, China Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, Guangdong, China
    Atherosclerosis 239:566-70. 2015
  4. doi MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression
    Qinggang Tian
    Department of General Surgery, The 4th Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014040, P R China
    Int J Mol Med 38:1587-1595. 2016
  5. pmc SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
    Nathan L Price
    Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and Cell Biology, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 36:1180-93. 2016
  6. pmc DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer
    Haixin Yin
    Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing 100005, PR China
    Sci Rep 6:18824. 2016
  7. doi MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling
    Jingjing Qu
    Department of Respiratory Medicine, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P R China
    Int J Oncol 47:2141-52. 2015
  8. doi Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric age
    Francesco Martino
    Center of Clinic Lipid Research, Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Clin Sci (Lond) 129:963-72. 2015
  9. doi MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
    Int Heart J 56:365-71. 2015
  10. pmc Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis
    Denuja Karunakaran
    From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada D K, M A N, L R, M G, E R, P S, K J R Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada A B T, M A N, R S, J P P, M E H, K J R National Research Council of Canada, Ottawa, Ontario, Canada R S, J P P Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H Charney Division of Cardiology, New York University School of Medicine M O, K J M and Department of Molecular Medicine and Surgery L P, U H and Department of Medicine L M, Karolinska Institute, Stockholm, Sweden
    Circ Res 117:266-78. 2015

Scientific Experts

  • Alessandra Magenta
  • Koh Ono
  • Pu Zhang
  • Takahiro Horie
  • Yajaira Suarez
  • Carlos Fernandez-Hernando
  • Cristina M Ramírez
  • Leigh Goedeke
  • Yasuhide Kuwabara
  • Takeshi Kimura
  • Osamu Baba
  • Tomohiro Nishino
  • Daniel Cirera-Salinas
  • Qinggang Tian
  • Nathan L Price
  • Haixin Yin
  • Erqun Song
  • Francesco Martino
  • Jingjing Qu
  • C Mandolini
  • Changjin Huang
  • Yancheng Lin
  • Weilie Ma
  • Denuja Karunakaran
  • Yang Song
  • Toru Kita
  • Masayuki Yokode
  • Ning Xu
  • Ruihua Cao
  • Rafael De Cabo
  • Julie A Mattison
  • Kathryn J Moore
  • Apana A L Takwi
  • Alberto Davalos
  • S Hani Najafi-Shoushtari
  • Fang Wang
  • Peng Song
  • Jing Zhang
  • Yao Xiao
  • Jia Yu
  • Jingling Yang
  • Wei Song
  • Furong Dai
  • Min Luo
  • Martin Wabitsch
  • Wenfeng Gao
  • Laurence Bianchini
  • Tuankui Guo
  • Yanni Ma
  • Weibin Wang
  • Lei Dong
  • Junwu Zhang
  • Yanting Wu
  • Zhiqing Song
  • Yun Liu
  • Guihua Yang
  • Zhigang Sun
  • Changzheng Liu
  • Bei Gong
  • Yuguo Zhang
  • Brandon Holtrup
  • Matthew Rodeheffer
  • Stephanie L Kwei
  • Rui Su
  • Bin Wang
  • Gentao Liu
  • Qi Luo
  • Zhizhen Zhang
  • Francesco Barilla
  • Allan Yi Liu
  • Gaoliang Ouyang
  • A Brianne Thrush
  • P Marcantonio
  • Cong Peng
  • Yuan Li
  • Ljubica Perisic
  • Mary Ellen Harper
  • Fabrizio Carlomosti
  • Xiaohua Gong
  • Eleni Ramphos
  • John P Pezacki
  • Panying Zeng
  • Chuannan Fan
  • Michèle Geoffrion
  • Wen Zhong
  • Anna Montali
  • Hong Zheng
  • Mireille Ouimet
  • Eliana Martino
  • Shasha Wu

Detail Information

Publications22

  1. pmc MicroRNA 33 regulates glucose metabolism
    Cristina M Ramírez
    Department of Medicine, Leon H Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 33:2891-902. 2013
    ..In this regard, we have recently demonstrated that miR-33a and miR33b, intronic miRNAs located within the sterol regulatory element-binding protein (SREBP) genes, regulate lipid ..
  2. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    ..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
  3. doi Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels
    Weilie Ma
    Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan, Guangdong, China Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, Guangdong, China
    Atherosclerosis 239:566-70. 2015
    ..MPD further promotes LDL receptor through reducing the PCSK9 level. Collectively, the study demonstrates that MPD potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. ..
  4. doi MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression
    Qinggang Tian
    Department of General Surgery, The 4th Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014040, P R China
    Int J Mol Med 38:1587-1595. 2016
    ..Therefore, miR‑33b/SALL4 may become a potential therapeutic target for the treatment of HCC...
  5. pmc SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
    Nathan L Price
    Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and Cell Biology, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 36:1180-93. 2016
    ..Together, these findings demonstrate a novel role of miR-33b in the regulation of adipocyte differentiation, with important implications for the development of obesity and metabolic disease. ..
  6. pmc DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer
    Haixin Yin
    Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing 100005, PR China
    Sci Rep 6:18824. 2016
    ..In conclusion, miR-33b acts as a tumor suppressor and hypermethylation of the CpG island upstream of miR-33b is responsible for its down-regulation in gastric cancer. ..
  7. doi MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling
    Jingjing Qu
    Department of Respiratory Medicine, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P R China
    Int J Oncol 47:2141-52. 2015
    ..In conclusion, the present study provided novel insight into the molecular mechanism of lung adenocarcinoma progression. MicroRNA-33b should be further investigated as a potential therapeutic target in human lung adenocarcinoma...
  8. doi Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric age
    Francesco Martino
    Center of Clinic Lipid Research, Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Clin Sci (Lond) 129:963-72. 2015
    ..05 respectively). Although it is only explorative, the present study could be the first to point to the use of miR-33a and miR-33b as early biomarkers for cholesterol levels in childhood, once validated in independent larger cohorts. ..
  9. doi MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
    Int Heart J 56:365-71. 2015
    ..In this review, we describe the current understanding of the functions of miRNAs in HDL metabolism and their potential in therapy for treating cardiometabolic diseases. ..
  10. pmc Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis
    Denuja Karunakaran
    From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada D K, M A N, L R, M G, E R, P S, K J R Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada A B T, M A N, R S, J P P, M E H, K J R National Research Council of Canada, Ottawa, Ontario, Canada R S, J P P Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H Charney Division of Cardiology, New York University School of Medicine M O, K J M and Department of Molecular Medicine and Surgery L P, U H and Department of Medicine L M, Karolinska Institute, Stockholm, Sweden
    Circ Res 117:266-78. 2015
    ..Bioinformatic pathway analysis predicts that miR-33 represses a cluster of genes controlling cellular energy metabolism that may be important in macrophage cholesterol efflux...
  11. pmc MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1
    Yancheng Lin
    State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China
    Sci Rep 5:9995. 2015
    ..These data indicate that miR-33b acts as an onco-suppressive microRNA in breast cancer progression by inhibiting the stemness and metastasis of breast cancer cells. ..
  12. pmc Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b
    Pu Zhang
    Key Laboratory of Luminescence and Real Time Analytical Chemistry Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
    Oncotarget 6:9834-53. 2015
    ....
  13. doi MicroRNA-33a/b in lipid metabolism – novel “thrifty” models
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 79:278-84. 2015
    ..In this review, we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the "thrifty" aspect...
  14. doi MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2
    Pu Zhang
    Key Laboratory of Luminescence and Real Time Analytical Chemistry Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, People s Republic of China Department of Bioengineering, Pennsylvania State University, University Park, PA 16801, United States Electronic address
    Toxicol Lett 234:151-61. 2015
    ..The observed activities of EF24 support its further evaluation as an anti-metastatic agent in melanoma therapy. ..
  15. pmc MicroRNA-33b suppresses migration and invasion by targeting c-Myc in osteosarcoma cells
    Ning Xu
    Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, No 23, Youzheng St, Nangang, Harbin, Heilongjiang, China
    PLoS ONE 9:e115300. 2014
    ..The findings of this study contribute to current understanding of the functions of miR-33b in osteosarcoma. ..
  16. doi Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques
    C Mandolini
    Geriatric Clinic, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, Chieti, Italy Clinical Research Center, Center of Excellence on Aging Ce S I, Chieti, Italy
    Nutr Metab Cardiovasc Dis 25:202-9. 2015
    ..Thus, the aim of this study was to investigate the modulation of the ABCA1 and ABCG1 pathway in human atherosclerotic plaques and microRNA involvement in its modulation...
  17. pmc MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo
    Takahiro Horie
    1 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 2 Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 3
    Sci Rep 4:5312. 2014
    ..Our mice will also aid in elucidating the roles of miR-33a/b in different genetic disease models. ..
  18. pmc Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels
    Ruihua Cao
    Department of Geriatric Cardiology, Chinese PLA General Hospital, No 28 Fuxing road, Beijing 100853, China
    Dis Markers 2014:781780. 2014
    ..Xuezhikang (XZK) is a marked natural HDL-raising polypill. We aim to evaluate the effects of XZK on the expression of circulating miR-33a/b in patients with low plasma HDL-C levels...
  19. pmc A regulatory role for microRNA 33* in controlling lipid metabolism gene expression
    Leigh Goedeke
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Mol Cell Biol 33:2339-52. 2013
    ..Altogether, these data support a regulatory role for the miRNA* species and suggest that miR-33 regulates lipid metabolism through both arms of the miR-33/miR-33* duplex...
  20. pmc A statin-regulated microRNA represses human c-Myc expression and function
    Apana A L Takwi
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, KY, USA
    EMBO Mol Med 4:896-909. 2012
    ..This work presents a highly promising therapeutic option, using drug repurposing and a miRNA as a biomarker, against cancers that overexpress c-Myc...
  21. pmc miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
    Alberto Davalos
    Department of Medicine and Cell Biology, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 108:9232-7. 2011
    ....