Gene Symbol: MIR33B
Description: microRNA 33b
Alias: MIRN33B, hsa-mir-33b
- MicroRNA 33 regulates glucose metabolismCristina M Ramírez
Department of Medicine, Leon H Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA
Mol Cell Biol 33:2891-902. 2013..In this regard, we have recently demonstrated that miR-33a and miR33b, intronic miRNAs located within the sterol regulatory element-binding protein (SREBP) genes, regulate lipid ..
- MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasisS Hani Najafi-Shoushtari
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Science 328:1566-9. 2010..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
- Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levelsWeilie Ma
Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan, Guangdong, China Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, Guangdong, China
Atherosclerosis 239:566-70. 2015..MPD further promotes LDL receptor through reducing the PCSK9 level. Collectively, the study demonstrates that MPD potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. ..
- MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expressionQinggang Tian
Department of General Surgery, The 4th Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014040, P R China
Int J Mol Med 38:1587-1595. 2016..Therefore, miR‑33b/SALL4 may become a potential therapeutic target for the treatment of HCC...
- SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte DifferentiationNathan L Price
Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and Cell Biology, New York University School of Medicine, New York, New York, USA
Mol Cell Biol 36:1180-93. 2016..Together, these findings demonstrate a novel role of miR-33b in the regulation of adipocyte differentiation, with important implications for the development of obesity and metabolic disease. ..
- DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancerHaixin Yin
Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing 100005, PR China
Sci Rep 6:18824. 2016..In conclusion, miR-33b acts as a tumor suppressor and hypermethylation of the CpG island upstream of miR-33b is responsible for its down-regulation in gastric cancer. ..
- MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signalingJingjing Qu
Department of Respiratory Medicine, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P R China
Int J Oncol 47:2141-52. 2015..In conclusion, the present study provided novel insight into the molecular mechanism of lung adenocarcinoma progression. MicroRNA-33b should be further investigated as a potential therapeutic target in human lung adenocarcinoma...
- Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric ageFrancesco Martino
Center of Clinic Lipid Research, Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Clin Sci (Lond) 129:963-72. 2015..05 respectively). Although it is only explorative, the present study could be the first to point to the use of miR-33a and miR-33b as early biomarkers for cholesterol levels in childhood, once validated in independent larger cohorts. ..
- MicroRNAs and High-Density Lipoprotein Cholesterol MetabolismKoh Ono
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Int Heart J 56:365-71. 2015..In this review, we describe the current understanding of the functions of miRNAs in HDL metabolism and their potential in therapy for treating cardiometabolic diseases. ..
- Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisDenuja Karunakaran
From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada D K, M A N, L R, M G, E R, P S, K J R Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada A B T, M A N, R S, J P P, M E H, K J R National Research Council of Canada, Ottawa, Ontario, Canada R S, J P P Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H Charney Division of Cardiology, New York University School of Medicine M O, K J M and Department of Molecular Medicine and Surgery L P, U H and Department of Medicine L M, Karolinska Institute, Stockholm, Sweden
Circ Res 117:266-78. 2015..Bioinformatic pathway analysis predicts that miR-33 represses a cluster of genes controlling cellular energy metabolism that may be important in macrophage cholesterol efflux...
- MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1Yancheng Lin
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China
Sci Rep 5:9995. 2015..These data indicate that miR-33b acts as an onco-suppressive microRNA in breast cancer progression by inhibiting the stemness and metastasis of breast cancer cells. ..
- Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33bPu Zhang
Key Laboratory of Luminescence and Real Time Analytical Chemistry Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Oncotarget 6:9834-53. 2015....
- MicroRNA-33a/b in lipid metabolism – novel “thrifty” modelsKoh Ono
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Circ J 79:278-84. 2015..In this review, we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the "thrifty" aspect...
- MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2Pu Zhang
Key Laboratory of Luminescence and Real Time Analytical Chemistry Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, People s Republic of China Department of Bioengineering, Pennsylvania State University, University Park, PA 16801, United States Electronic address
Toxicol Lett 234:151-61. 2015..The observed activities of EF24 support its further evaluation as an anti-metastatic agent in melanoma therapy. ..
- MicroRNA-33b suppresses migration and invasion by targeting c-Myc in osteosarcoma cellsNing Xu
Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, No 23, Youzheng St, Nangang, Harbin, Heilongjiang, China
PLoS ONE 9:e115300. 2014..The findings of this study contribute to current understanding of the functions of miR-33b in osteosarcoma. ..
- Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaquesC Mandolini
Geriatric Clinic, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, Chieti, Italy Clinical Research Center, Center of Excellence on Aging Ce S I, Chieti, Italy
Nutr Metab Cardiovasc Dis 25:202-9. 2015..Thus, the aim of this study was to investigate the modulation of the ABCA1 and ABCG1 pathway in human atherosclerotic plaques and microRNA involvement in its modulation...
- MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivoTakahiro Horie
1 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 2 Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 3
Sci Rep 4:5312. 2014..Our mice will also aid in elucidating the roles of miR-33a/b in different genetic disease models. ..
- Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levelsRuihua Cao
Department of Geriatric Cardiology, Chinese PLA General Hospital, No 28 Fuxing road, Beijing 100853, China
Dis Markers 2014:781780. 2014..Xuezhikang (XZK) is a marked natural HDL-raising polypill. We aim to evaluate the effects of XZK on the expression of circulating miR-33a/b in patients with low plasma HDL-C levels...
- A regulatory role for microRNA 33* in controlling lipid metabolism gene expressionLeigh Goedeke
Department of Medicine, New York University School of Medicine, New York, NY, USA
Mol Cell Biol 33:2339-52. 2013..Altogether, these data support a regulatory role for the miRNA* species and suggest that miR-33 regulates lipid metabolism through both arms of the miR-33/miR-33* duplex...
- A statin-regulated microRNA represses human c-Myc expression and functionApana A L Takwi
Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, KY, USA
EMBO Mol Med 4:896-909. 2012..This work presents a highly promising therapeutic option, using drug repurposing and a miRNA as a biomarker, against cancers that overexpress c-Myc...
- miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signalingAlberto Davalos
Department of Medicine and Cell Biology, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 108:9232-7. 2011....