MIR222

Summary

Gene Symbol: MIR222
Description: microRNA 222
Alias: MIRN222, miRNA222, mir-222
Species: human

Top Publications

  1. doi MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells
    Shanliang Zhong
    Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China
    Gene 531:8-14. 2013
  2. ncbi miR-221/222 promote malignant progression of glioma through activation of the Akt pathway
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P R China
    Int J Oncol 36:913-20. 2010
  3. ncbi Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P R China
    Int J Oncol 36:1503-12. 2010
  4. doi microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression
    Patrizia Dentelli
    Department of Internal Medicine, University of Torino, Torino, Italy
    Arterioscler Thromb Vasc Biol 30:1562-8. 2010
  5. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
  6. ncbi PUMA is a novel target of miR-221/222 in human epithelial cancers
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, PR China
    Int J Oncol 37:1621-6. 2010
  7. doi miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA
    Fangfang Jiang
    Institute of Stomatological Research, Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong 510055, P R China
    Oncol Rep 31:1255-62. 2014
  8. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
  9. doi Elevated expression of tumor miR-222 in pancreatic cancer is associated with Ki67 and poor prognosis
    Chonglek Lee
    Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital Affiliated to Fudan University, No 12, WuRuWuQi Middle Road, Shanghai, 200040, China
    Med Oncol 30:700. 2013
  10. ncbi miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    Silvia Galardi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    J Biol Chem 282:23716-24. 2007

Research Grants

Scientific Experts

Detail Information

Publications88

  1. doi MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells
    Shanliang Zhong
    Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China
    Gene 531:8-14. 2013
    ..The most importance is that we identify two miRNAs (miR-222 and miR-29a) involved in drug-resistance, at least in part via targeting PTEN...
  2. ncbi miR-221/222 promote malignant progression of glioma through activation of the Akt pathway
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P R China
    Int J Oncol 36:913-20. 2010
    ..Our results suggest that miR-221/222 co-enhance the glioma malignant phenotype via activation of the Akt pathway mediated by regulation of common gene expression...
  3. ncbi Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P R China
    Int J Oncol 36:1503-12. 2010
    ..These data indicate for the first time a mechanism involving STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells...
  4. doi microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression
    Patrizia Dentelli
    Department of Internal Medicine, University of Torino, Torino, Italy
    Arterioscler Thromb Vasc Biol 30:1562-8. 2010
    ..Among them, microRNA-221/222 (miR-221/222) seem to negatively modulate vascular remodeling by targeting different target genes. Here, we investigated their potential contribution to inflammation-mediated neovessel formation...
  5. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
    ..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
  6. ncbi PUMA is a novel target of miR-221/222 in human epithelial cancers
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, PR China
    Int J Oncol 37:1621-6. 2010
    ..Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers...
  7. doi miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA
    Fangfang Jiang
    Institute of Stomatological Research, Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong 510055, P R China
    Oncol Rep 31:1255-62. 2014
    ..Our results suggest that miR-222 targets the expression of PUMA in OSCC cells and affects cell growth, invasive and apoptotic abilities. Thus, PUMA may be a possible new target for the treatment of OSCC. ..
  8. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
    ..Genistein, a potential nontoxic chemopreventive agent, restores expression of ARHI and may be an important dietary therapeutic agent for treating prostate cancer...
  9. doi Elevated expression of tumor miR-222 in pancreatic cancer is associated with Ki67 and poor prognosis
    Chonglek Lee
    Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital Affiliated to Fudan University, No 12, WuRuWuQi Middle Road, Shanghai, 200040, China
    Med Oncol 30:700. 2013
    ..Our data suggest the potential of micro-RNA-222 as a prognostic biomarker for the pancreatic cancer. ..
  10. ncbi miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    Silvia Galardi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    J Biol Chem 282:23716-24. 2007
    ....
  11. pmc miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer
    Michael S Hwang
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech, Inc, South San Francisco, California, United States of America
    PLoS ONE 8:e66502. 2013
    ..These results suggest that ADIPOR1 may play an important role in breast cancer progression and metastasis, and could potentially offer an alternative therapeutic strategy for basal-like breast cancer patients...
  12. doi TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer
    Susanna Stinson
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc, South San Francisco, CA 94080, USA
    Sci Signal 4:ra41. 2011
    ..We conclude that by promoting EMT, miR-221/222 may contribute to the more aggressive clinical behavior of basal-like breast cancers...
  13. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
    ..MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. However, the association of miR-221/222 with glioma cell invasion and survival remains unknown...
  14. pmc Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma
    Gianfranco Mattia
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Pigment Cell Melanoma Res 24:953-65. 2011
    ..Finally, in vivo studies confirmed the contribution of miR-222 to the increased invasive potential obtained by ETS- silencing...
  15. pmc miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ
    C Quintavalle
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples, Italy
    Oncogene 31:858-68. 2012
    ..In conclusion, our results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPμ protein expression...
  16. doi MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17
    Ke Xu
    State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, PR China
    Exp Cell Res 318:2168-77. 2012
    ..Our findings suggest that miR-222 could play a role in the development of MDR by modulation of ADAM-17, the new MDR treatment target in colorectal carcinoma cells...
  17. doi miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells
    Jianwei Hao
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, PR China
    Oncol Rep 27:1504-10. 2012
    ..We conclude that miR-221/222 function as oncogenic microRNAs in human gliomas, at least in part, by targeting Cx43...
  18. pmc Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal
    Yuanzhi Lu
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:42292-302. 2011
    ..In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen...
  19. pmc Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1
    Ryo Ueda
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 106:10746-51. 2009
    ..This study suggests development of novel miR-targeted therapy to promote cytolysis of tumor cells...
  20. pmc miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    Michela Garofalo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 16:498-509. 2009
    ..Finally, we demonstrate that the MET oncogene is involved in miR-221&222 activation through the c-Jun transcription factor...
  21. doi Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    Thomas Greither
    Clinic of Radiation Therapy, Martin Luther University, Halle, Wittenberg, Germany
    Int J Cancer 126:73-80. 2010
    ..Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression...
  22. ncbi Regulation of p27Kip1 by miRNA 221/222 in glioblastoma
    Jana K Gillies
    Ottawa Health Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada
    Cell Cycle 6:2005-9. 2007
    ..These data show that p27(Kip1) is a direct target for microRNAs 221 and 222, and suggest a role for these microRNAs in promoting the aggressive growth of human glioblastoma...
  23. ncbi MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle
    Rosa Visone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Naples, Italy
    Endocr Relat Cancer 14:791-8. 2007
    ..Therefore, the data reported here demonstrate that miR-221 and miR-222 are endogenous regulators of p27(Kip1) protein expression, and thereby, the cell cycle...
  24. pmc MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    Tyler E Miller
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:29897-903. 2008
    ..This finding also provides the rationale for the application of altered expression of specific miRNAs as a predictive tamoxifen-resistant breast cancer marker...
  25. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    ....
  26. pmc MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 6:131-9. 2009
    ..Our results indicate that hsa-miR-222 plays an important role in OTSCC invasion, and may serve as a novel therapeutic target for OTSCC patients at risk of metastatic disease...
  27. pmc MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
    Nadia Felli
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Proc Natl Acad Sci U S A 102:18081-6. 2005
    ..Furthermore, the results on kit+ erythroleukemic cells suggest a potential role of these miRs in cancer therapy...
  28. pmc The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 69:3356-63. 2009
    ..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
  29. doi MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Cancer Res 16:867-75. 2010
    ..This study aims to profile the expressions of 156 microRNAs (miRNA) in hepatocellular carcinoma (HCC) and to characterize the functions of miR-222, the most significantly upregulated candidate identified...
  30. pmc The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
    Neri Mercatelli
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 3:e4029. 2008
    ..We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity...
  31. doi Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer
    Miki Fuse
    Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan
    J Hum Genet 57:691-9. 2012
    ..Identification and categorization of the molecular pathways regulated by tumor suppressive miRNAs could provide new information about the molecular mechanisms of PCa tumorigenesis...
  32. pmc miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells
    Li Ping Zeng
    The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China
    J Cell Mol Med 20:559-67. 2016
    ..Therefore, miR-222 may be a novel therapeutic target for bladder cancer. ..
  33. doi Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III
    Michela Visani
    Department of Pharmacy and Biotechnology, FaBiT, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Mol Oncol 8:417-30. 2014
    ..This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. ..
  34. pmc HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer
    S Mardente
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Biomed Res Int 2015:512027. 2015
    ..The newly identified pathway HMGB1/RAGE/miR221/222 may represent an effective way of tumor escape from immune surveillance that could be used to develop new therapeutic strategies against anaplastic tumors. ..
  35. doi MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway
    Hongyu Shen
    The Fourth Clinical School of Nanjing Medical University, Baiziting 42, Nanjing 210009, Jiangsu, China Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Baiziting 42, Nanjing 210009, Jiangsu, China
    Gene 596:110-118. 2017
    ..The aim of this study was to explore the possible mechanism by which miR-222 affects sensitivity to ADR...
  36. doi High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222
    Eleonora Brognara
    Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
    Int J Oncol 48:1029-38. 2016
    ..In addition, co-administration of R8-PNA-a221 and R8-PNA-a222 induced apoptosis of TMZ-treated T98G cells at a level higher than that obtained following singular administration of R8-PNA-a221 or R8-PNA-a222...
  37. doi Correlations between the expression levels of micro-RNA146b, 221, 222 and p27Kip1 protein mRNA and the clinicopathologic parameters in papillary thyroid cancers
    F Acibucu
    Cumhuriyet University, Endocrinology, Sivas, Turkey
    Exp Clin Endocrinol Diabetes 122:137-43. 2014
    ..It has been shown that miRNA 221, 222 and 146b are increasingly expressed while p27(Kip1) is suppressed in papillary thyroid cancer (PTC)...
  38. pmc miR-221/222 control luminal breast cancer tumor progression by regulating different targets
    Patrizia Dentelli
    Department of Medical Sciences University of Torino Torino, Italy
    Cell Cycle 13:1811-26. 2014
    ..Pre-miR-221/222 use in the aggressive luminal subtype may be a powerful therapeutic anti-cancer strategy. ..
  39. doi Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222
    Dan Dan Yu
    The First Clinical School of Nanjing Medical University, Nanjing, China
    Tumour Biol 37:3227-35. 2016
    ..In conclusion, exosomes are effective in transmitting drug resistance and the delivery of miR-222 via exosomes may be a mechanism. ..
  40. pmc Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs
    Wei xian Chen
    The Fourth Clinical School of Nanjing Medical University, Nanjing, Jiangsu, China Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China
    PLoS ONE 9:e95240. 2014
    ..Our results suggest that drug-resistant breast cancer cells may spread resistance capacity to sensitive ones by releasing exosomes and that such effects could be partly attributed to the intercellular transfer of specific miRNAs. ..
  41. doi Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers
    Wei Long
    Department of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China
    Cell Physiol Biochem 33:1304-15. 2014
    ..Circulating miRNAs have recently been shown to serve as diagnostic/prognostic biomarkers in patients with cancers. Our current study focused on the altered expression of serum miRNAs and their correlation with PCOS...
  42. pmc Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotype
    Sanket H Shah
    a Cancer Biology University of Miami Miami, FL USA
    Cancer Biol Ther 16:1671-81. 2015
    ..Collectively, our results demonstrate that CAF-secreted microRNAs are directly involved in ER-repression, and may contribute to the MAPK-induced ER repression in breast cancer cells...
  43. pmc Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by hepatitis B virus X protein in malignant hepatocytes
    Manikankana Bandopadhyay
    ICMR Virus Unit, Kolkata, GB 4, 1st Floor, ID and BG Hospital Campus, 57, Dr, S C Banerjee Road, Beliaghata, Kolkata West Bengal, 700010, India
    BMC Cancer 14:721. 2014
    ..Alterations in miRNA expressions are frequently noted in HCC. This study is aimed to examine the role of HBx protein in the modulation of oncogenic miRNA-21, miRNA-222 and tumor suppressor miRNA-145 in malignant hepatocytes...
  44. doi Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells
    Lina Wang
    Department of Biochemistry and Molecular Biology, Medical School of Shandong University, Jinan 250012, Shandong, China Jinan Infectious Disease Hospital, Jinan 250012, Shandong, China
    Gene 572:252-8. 2015
    ..To investigate the role of miR-221/222 in cell proliferation and apoptosis in human prostate cancer cells, and examine the effects of miR-221/222 on caspase-10 expression...
  45. doi β-elemene reverses chemoresistance of breast cancer via regulating MDR-related microRNA expression
    Jun Zhang
    Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China
    Cell Physiol Biochem 34:2027-37. 2014
    ....
  46. pmc Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism
    Felix Jansen
    Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich Wilhelms University, Bonn, Germany
    J Cell Mol Med 19:2202-14. 2015
    ..In pathological hyperglycaemic conditions, EMP-mediated miR-222-dependent anti-inflammatory effects are reduced. ..
  47. pmc Overexpression of primary microRNA 221/222 in acute myeloid leukemia
    Anna Rommer
    Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 13:364. 2013
    ..In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations...
  48. pmc miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers
    Youjia Hua
    Feinberg School of Medicine, Division Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    BMC Genomics 14:179. 2013
    ..We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect)...
  49. doi Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China
    Oncol Rep 27:854-60. 2012
    ..Taken together, our study indicates that downregulated miR-221/222 can sensitize glioma cells to TMZ by regulating apoptosis independently of p53 status...
  50. doi MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway
    Qifeng Li
    Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200092, PR China
    FEBS Lett 587:1742-8. 2013
    ..Taken together, our findings reveal a new regulatory mechanism of miR-222 and suggest that miR-222 might be a potential target in glioma therapy...
  51. doi MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia
    Ebru Coskun
    Hematology and Oncology, Charite, University Hospital Benjamin Franklin, Berlin, Germany
    Leuk Res 37:647-56. 2013
    ..Importantly, miR-222 may impact leukemogenesis by altering expression of the proto-oncogene ETS1 in acute leukemia...
  52. pmc The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway
    M Cristina Errico
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Int J Cancer 133:879-92. 2013
    ....
  53. pmc miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases
    Ernest K Amankwah
    Department of Cancer Epidemiology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Asian J Androl 15:226-30. 2013
    ..Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved...
  54. doi MicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation
    R C Gehrau
    Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA, USA
    Am J Transplant 13:729-37. 2013
    ..Seven microRNAs were successfully validated in the validation set using QPCR. We have identified a 9-microRNA signature able to identify early post-LT patients at high risk of severe HCVrec during long-term follow-up...
  55. doi HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells
    Stefania Mardente
    Department of Experimental Medicine, Sapienza University of Rome, I 00161 Rome, Italy
    Oncol Rep 28:2285-9. 2012
    ..The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility...
  56. doi High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells
    Yunzhi Zhang
    Department of Infectious Disease, Shanghai Public Health Clinical Center affiliated to Fudan University, Shanghai, People s Republic of China
    Mol Cell Biochem 357:363-71. 2011
    ..These results suggested that HMGA1 is a positive regulator of miR-222, and HMGA1 overexpression might contribute to dysregulation of Akt signaling in NSCLC...
  57. doi Urinary sediment ICAM-1 level in lupus nephritis
    J Guan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Lupus 21:1190-5. 2012
    ....
  58. doi Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Skårn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    ....
  59. doi Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model
    Ioannis Pandis
    Biomedical Sciences Research Centre Alexander Fleming, Institute of Immunology, Vari 16672, Greece
    Ann Rheum Dis 71:1716-23. 2012
    ..To identify novel microRNA (miR) associations in synovial fibroblasts (SF), by performing miR expression profiling on cells isolated from the human tumour necrosis factor (TNF) transgenic mouse model (TghuTNF, Tg197) and patients biopsies...
  60. doi A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration
    Xavier M Keutgen
    Division of Endocrine Surgery, Department of Surgery, Department of Pathology, Institute for Computational Biomedicine, NY 10021, USA
    Clin Cancer Res 18:2032-8. 2012
    ..Hemi- or total thyroidectomy has, therefore, been routinely advocated for definitive diagnosis. In this study, we analyzed miRNA expression in indeterminate FNA samples and determined its prognostic effects on final pathologic diagnosis...
  61. doi Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
    Na Li
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, Chongqing 400038, China
    FEBS Lett 586:722-8. 2012
    ..Collectively, H. pylori may function as an initiator in the process of carcinogenesis by up-regulating miR-222, which further participates in the progression of cancer by promoting proliferation and inhibiting RECK...
  62. pmc miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222
    M Acunzo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Oncogene 31:634-42. 2012
    ..Moreover, we found that miR-130a reduced migratory capacity of NSCLC. A better understanding of MET-miR-221 and 222 axis regulation in drug resistance is the key in developing new strategies in NSCLC therapy...
  63. ncbi MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Gut 61:1600-9. 2012
    ..MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer...
  64. pmc The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer, Institute, Harvard Medical School, Boston, MA 02115, USA
    Prostate 72:1093-103. 2012
    ....
  65. ncbi The expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and microRNA 221 and 222 in prostate cancer
    D Lin
    Urology Department, The First Affiliated Hospital of Suzhou University, Suzhou, China
    J Int Med Res 39:1870-5. 2011
    ..Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation...
  66. doi MicroRNAs and potential target interactions in psoriasis
    John R Zibert
    Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    J Dermatol Sci 58:177-85. 2010
    ..MicroRNAs are important in the pathogenesis of human diseases such as immunological disorders, as they regulate a broad range of biological processes...
  67. pmc Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex
    Marco Gabbianelli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
    Haematologica 95:1253-60. 2010
    ..MicroRNAs (miRs) play a pivotal role in normal hematopoiesis: downmodulation of miR-221/222 stimulates human erythropoietic proliferation through upmodulation of the kit receptor...
  68. doi MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27
    Michela Frenquelli
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 115:3949-59. 2010
    ..These data indicate that the miR-221/222 cluster modulates the expression of p27 protein in CLL cells and lead to suggest that miR-221/222 and p27 may represent a regulatory loop that helps maintaining CLL cells in a resting condition...
  69. doi Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets
    Simone Treiger Sredni
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Children s Memorial Hospital, 2300 Children s Plaza, Chicago, IL 60614, USA
    Childs Nerv Syst 26:279-83. 2010
    ..The aim of this study is to search for new therapeutic targets for atypical teratoid-rhabdoid tumors (ATRT)...
  70. doi [Up-regulation of p27(kip1) by miR-221/222 antisense oligonucleotides enhances the radiosensitivity of U251 glioblastoma]
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, 300052 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:634-8. 2009
    ..To study the radiation-sensitizing effect of up-regulating p27(kip1) expression by knocking down miR-221/222 in the U251 human glioblastoma cell line...
  71. doi Hematopoiesis-related microRNA expression in myelodysplastic syndromes
    Aina Pons
    Unit of Human Anatomy, Molecular Oncology Laboratory, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    Leuk Lymphoma 50:1854-9. 2009
    ..miR-222 ( p = 0.0023) and miR-181a ( p = 0.014) expression was higher in AML than in MDS in both BM and PB. This study adds further evidence to the role of miRNAs in the pathogenesis of MDS and their transformation into AML...
  72. doi Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q)...
  73. doi Hsa-miR-222 is involved in differentiation of endometrial stromal cells in vitro
    Kun Qian
    Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Endocrinology 150:4734-43. 2009
    ....
  74. pmc MicroRNA-221-222 regulate the cell cycle in mast cells
    Ramon J Mayoral
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Immunol 182:433-45. 2009
    ..Our study provides further insights on miR-221-222 transcriptional regulation as well as evidences that miR-221-222 regulate cell cycle checkpoints in mast cells in response to acute activation stimuli...
  75. ncbi A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias
    Sebastian Kreil
    Leuk Res 33:e168-9. 2009
  76. ncbi Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2453-9. 2011
    ..Oncogenic KRAS plays several key roles in a three-dimensional (3D) colonic-crypt model. However, miRNA expression regulated by oncogenic KRAS in this model is still elusive...
  77. pmc MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival
    Kaitlyn Wurz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Genes Chromosomes Cancer 49:577-84. 2010
    ..01). In contrast, CDKN1B expression was not associated with miR-221 or miR-222 expression. Neither somatic mutations nor methylation of the studied region explained the alterations in miR-221 and miR-222 expression in most carcinomas...
  78. pmc MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
    Manuela Ferracin
    Dipartimento di Medicina Sperimentale e Diagnostica Università di Ferrara, Ferrara, Italy
    Mol Cancer 9:123. 2010
    ....
  79. doi miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27(Kip1)- and MEK/ERK-mediated cell cycle regulation
    Rongyang Dai
    Department of Biochemistry of Luzhou Medical College, Luzhou 646000, Sichuan, China
    Biol Chem 391:791-801. 2010
    ..Our results suggest that suppression of miR-221/222 plays a crucial role in the protection against apoptosis induced by ER stress in HCC cells...
  80. doi A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility
    Martijn Kedde
    Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Nat Cell Biol 12:1014-20. 2010
    ..We have therefore uncovered a novel RBP-induced structural switch modulating microRNA-mediated gene expression regulation...
  81. doi MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24
    Yan Cao
    Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin 150001 Heilongjiang, China
    Tumour Biol 32:179-88. 2011
    ..The synergy effect between miRNA-19a and arsenic trioxide that advocates targeting the mir-19a may represent a potential approach to enhance the efficacy and safety of ATO to treat bladder cancer by a decrease in dose...
  82. pmc MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways
    X Rao
    Interdisciplinary Biochemistry Graduate Program, Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, USA
    Oncogene 30:1082-97. 2011
    ....
  83. pmc Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits
    Matteo Brioschi
    Dipartimento di Biologia e Genetica per le Scienze Mediche, Facolta di Medicina, Universita degli Studi di Milano, Milan, Italy
    Neoplasia 12:866-76. 2010
    ....
  84. doi Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors
    Marita Koelz
    Clinical Institute of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Int J Oncol 38:503-11. 2011
    ..Although miR-221/222 expression does not have an impact on diagnostics, it could be considered as a tool for future therapeutic strategies for GISTs, especially for tumors with secondary resistance to tyrosine kinase inhibitors...
  85. pmc MicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma
    Linwah Yip
    Department of Surgery, Section of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Surg Oncol 18:2035-41. 2011
    ..MicroRNAs (miRNAs) are dysregulated in various tumors types, and some of them serve as markers of poor prognosis. In this study, we evaluated miRNA expression as a marker of more aggressive behavior in PTC...
  86. doi [The role of mir-221/222 in inhibiting endoplasmic reticulum stress-induced human hepatocarcinoma cell apoptosis]
    You ping Liu
    Department of Biochemistry, Luzhou Medical College, Luzhou Sichuan, China
    Zhonghua Gan Zang Bing Za Zhi 19:191-5. 2011
    ..To investigate the role of miR-221/222 in inhibiting endoplasmic reticulum stress-induced human hepatocarcinoma cells apoptosis...
  87. doi miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer
    Susanna Stinson
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech, Inc, South San Francisco, CA, USA
    Sci Signal 4:pt5. 2011
    ..TRPS1 inhibited EMT by directly repressing expression of ZEB2 (Zinc finger E-box-binding homeobox 2). Therefore, miR-221/222 may contribute to the aggressive clinical behavior of basal-like breast cancers...

Research Grants1

  1. Novel System to Study Telomere Dynamics in Hemotopoiesis
    Ruben Carrasco; Fiscal Year: 2005
    ..He also holds a Ph.D. in Biochemistry. The research will be carried out in a cancer/aging biology laboratory within the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School, under the mentorship of Dr. Ron DePinho. ..