MIR21

Summary

Gene Symbol: MIR21
Description: microRNA 21
Alias: MIRN21, hsa-mir-21, miR-21, miRNA21
Species: human

Top Publications

  1. doi miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism
    Shuji Fujita
    Division of Host Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Mol Biol 378:492-504. 2008
  2. pmc MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
    Masahiro Seike
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12085-90. 2009
  3. ncbi MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein
    Yanhui Lou
    Department of Gynecology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, P R China
    Int J Mol Med 26:819-27. 2010
  4. ncbi MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
  5. doi MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    Thales Papagiannakopoulos
    Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Cancer Res 68:8164-72. 2008
  6. ncbi MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    Shuomin Zhu
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Biol Chem 282:14328-36. 2007
  7. pmc MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    Galina Gabriely
    Center of Neurologic Diseases, Brigham and Women s Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA
    Mol Cell Biol 28:5369-80. 2008
  8. pmc Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    Xuezhong Cai
    Box 3025, Duke University Medical Center, Durham, NC 27710, USA
    RNA 10:1957-66. 2004
  9. doi MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
    Tao Li
    Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, China
    Biochem Biophys Res Commun 383:280-5. 2009
  10. doi MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G
    Yang Chen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cancer Lett 272:197-205. 2008

Research Grants

  1. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
  2. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
  3. CONTROL OF DIFFERENTIATION IN COLON CARCINOMA
    Luzhe Sun; Fiscal Year: 2001
  4. Role of BCL-6 in Allergic Immune Responses
    Alexander Dent; Fiscal Year: 2005
  5. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008

Detail Information

Publications148 found, 100 shown here

  1. doi miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism
    Shuji Fujita
    Division of Host Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Mol Biol 378:492-504. 2008
    ..Since exogenous miR-21 expression moderately induced endogenous miR-21, an evolutionarily conserved double-negative feedback regulation would be operating as a mechanism to sustain miR-21 expression...
  2. pmc MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
    Masahiro Seike
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12085-90. 2009
    ....
  3. ncbi MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein
    Yanhui Lou
    Department of Gynecology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, P R China
    Int J Mol Med 26:819-27. 2010
    ..Collectively, our findings suggest miR-21 may be important in the initiation and progression of EOC as an oncomiR, likely through regulating PTEN...
  4. ncbi MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
    ..Our data suggest that aberrantly expressed miR-21 may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes...
  5. doi MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    Thales Papagiannakopoulos
    Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Cancer Res 68:8164-72. 2008
    ..These findings establish miR-21 as an important oncogene that targets a network of p53, TGF-beta, and mitochondrial apoptosis tumor suppressor genes in glioblastoma cells...
  6. ncbi MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    Shuomin Zhu
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Biol Chem 282:14328-36. 2007
    ..Thus, down-regulation of TPM1 by mir-21 may explain, at least in part, why suppression of mir-21 can inhibit tumor growth, further supporting the notion that mir-21 functions as an oncogene...
  7. pmc MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    Galina Gabriely
    Center of Neurologic Diseases, Brigham and Women s Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA
    Mol Cell Biol 28:5369-80. 2008
    ....
  8. pmc Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    Xuezhong Cai
    Box 3025, Duke University Medical Center, Durham, NC 27710, USA
    RNA 10:1957-66. 2004
    ..Together, these data show that human pri-miRNAs are not only structurally similar to mRNAs but can, in fact, function both as pri-miRNAs and mRNAs...
  9. doi MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
    Tao Li
    Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, China
    Biochem Biophys Res Commun 383:280-5. 2009
    ..Gene therapy using miR-21 inhibition strategy may therefore be useful as a prostate cancer therapy...
  10. doi MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G
    Yang Chen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cancer Lett 272:197-205. 2008
    ..Together, these results indicate that miR-21 expression plays a key role in regulating cellular processes in glioblastomas and may serve as a target for effective therapies...
  11. doi MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells
    Qing Yao
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou 510275, PR China
    Biochem Biophys Res Commun 388:539-42. 2009
    ..These results suggest that miR-21 may play an oncogenic role in the cellular processes of cervical cancer and may serve as a target for effective therapies...
  12. doi MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor
    Jinsong Li
    Oral and Maxillofacial Surgery, and Breast Tumor Center, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Clin Cancer Res 15:3998-4008. 2009
    ..We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis...
  13. doi Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas
    H J Kwak
    Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Oncogene 30:2433-42. 2011
    ..Taken together, these results suggest that the post-transcriptional regulation of Spry2 by miR-21 has an essential role on the malignant progression of human gliomas. Thus, Spry2 may be a novel therapeutic target for treating gliomas...
  14. doi Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR
    Athina Markou
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece
    Clin Chem 54:1696-704. 2008
    ..We evaluated the prognostic value of mature microRNA-21 (miR-21) and mature microRNA-205 (miR-205) overexpression in non-small cell lung cancer (NSCLC)...
  15. doi Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia
    Yasuo Yamanaka
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Blood 114:3265-75. 2009
    ..Collectively, these results provide important new insight into the pathogenesis of NK-cell lymphoma/leukemia and suggest targeting miR-21 and/or miR-155 may represent a useful approach to treating NK-cell lymphoma/leukemia...
  16. pmc miR-21 promotes keratinocyte migration and re-epithelialization during wound healing
    Xue Yang
    Model Organism Division, E Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P R China
    Int J Biol Sci 7:685-90. 2011
    ..Taken together, our results demonstrate that miR-21 promotes keratinocyte migration and boosts re-epithelialization during skin wound healing...
  17. pmc PTEN modulates miR-21 processing via RNA-regulatory protein RNH1
    Youn Jae Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    PLoS ONE 6:e28308. 2011
    ....
  18. doi miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma
    Qin Zhu
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Oncol Rep 27:1660-8. 2012
    ....
  19. doi MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4)
    Satoru Itani
    Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cancer Res Clin Oncol 138:1501-9. 2012
    ..In addition, we attempted to seek associations between the miRNA and their potential targets in MPNST...
  20. pmc DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
    Jixiao Niu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 287:21783-95. 2012
    ....
  21. ncbi BMPRII is a direct target of miR-21
    Wenming Qin
    State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 41:618-23. 2009
    ..These findings suggest that miR-21 may have a potential role in regulating the malignancy and metastatic abilities of prostate cancer cells and in self-renewal of stem cells by regulating the expression of BMPRII...
  22. doi Inhibition of mir-21, which is up-regulated during MYCN knockdown-mediated differentiation, does not prevent differentiation of neuroblastoma cells
    Jochen Buechner
    Department of Paediatrics, University Hospital of North Norway, 9038 Tromsø, Norway
    Differentiation 81:25-34. 2011
    ..We performed a miRNA profiling study on SK-N-BE (2) cells, and determined differentially expressed miRNAs during differentiation initiated by MYCN knockdown, using anti-MYCN short-hairpin RNA (shRNA) technology...
  23. doi The status of microRNA-21 expression and its clinical significance in human cutaneous malignant melanoma
    Li Jiang
    Department of Plastic and Burn Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Acta Histochem 114:582-8. 2012
    ..Thus, the status of microRNA-21 might be an independent prognostic factor for patients with cutaneous melanoma, and microRNA-21 has the potential of being a novel molecular target for the treatment of human cutaneous melanoma...
  24. doi miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
    Zhiyu Zhang
    1Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Lab Invest 88:1358-66. 2008
    ..Our findings suggest a potential regulatory pathway in which H. pylori infection upregulates expression of miR-21, which in turn downregulates RECK, and then leads to the development of gastric cancer...
  25. doi Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development
    Nobutake Yamamichi
    Department of Microbiology and Immunology, Division of Host Parasite Interaction, Faculty of Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 15:4009-16. 2009
    ..To better understand microRNA miR-21 function in carcinogenesis, we analyzed miR-21 expression patterns in different stages of colorectal cancer development using in situ hybridization (ISH)...
  26. doi Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells
    Haiyan Hu
    Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China
    Leuk Lymphoma 51:694-701. 2010
    ..Our data suggest that miR-21 may play an oncogenic role in the cellular processes of CML, and antisense inhibition of miR-21 may therefore be useful as CML therapy...
  27. ncbi Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
    Kazuo Motoyama
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Int J Oncol 36:1089-95. 2010
    ..Furthermore, our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies...
  28. doi MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells
    Guangdong Yang
    School of Kinesiology, Lakehead University, Thunder Bay, Canada
    J Cell Physiol 227:3192-200. 2012
    ..Take together, these results suggest that miR-21 participates in CSE/H(2)S-mediated-SMC differentiation by targeting SP1...
  29. doi TGF-β-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-β in HaCaT cells
    Tao Wang
    Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing 400038, China
    Int J Biochem Cell Biol 44:366-76. 2012
    ..Thus, our results suggest that miR-21 regulates the ability of epithelial cells to respond to TGF-β, with potential impact on epithelium homeostasis, wound-healing and tumorigenesis...
  30. doi Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma
    Nicolas Fischer
    Department of Urology, University of Bonn, Bonn, Germany
    Biochem Biophys Res Commun 417:29-34. 2012
    ..We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals...
  31. doi MicroRNA-21 expression is regulated by β-catenin/STAT3 pathway and promotes glioma cell invasion by direct targeting RECK
    Lei Han
    Department of Neurosurgery, Tianjin Medical University General Hospital, China
    CNS Neurosci Ther 18:573-83. 2012
    ..Recent studies report that miR-21 regulates cell invasion by targeting RECK, however, the underlying transcriptional regulation of miR-21 in glioma cells remains elusive...
  32. pmc Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines
    Ho Shin Gwak
    Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    PLoS ONE 7:e47449. 2012
    ..Our results show that miR-21 is a pivotal molecule for circumventing radiation-induced cell death in malignant glioma cells through the regulation of autophagy and provide a novel phenomenon for the acquisition of radio-resistance...
  33. pmc MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    Nils Habbe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:340-6. 2009
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  34. pmc Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy res
    Lilly Y W Bourguignon
    Endocrine Unit, Department of Medicine, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 284:26533-46. 2009
    ..Thus, this newly discovered HA-CD44 signaling pathway should provide important drug targets for sensitizing tumor cell apoptosis and overcoming chemotherapy resistance in breast cancer cells...
  35. doi Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    Jong Kook Park
    Ohio State University, Columbus, 43210, USA
    Pancreas 38:e190-9. 2009
    ..The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides...
  36. pmc Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma
    Aaron J Schetter
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 15:5878-87. 2009
    ..This study examines the potential clinical utility of an inflammatory gene expression signature as a prognostic biomarker for colon cancer in addition to previously examined miR-21 expression...
  37. pmc Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype
    Erin Connolly
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 173:856-64. 2008
    ..The combination of assays presented here supports a role for these miRNAs in the maintenance of the malignant transformation of hepatocytes...
  38. doi MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma
    Yukiharu Hiyoshi
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 15:1915-22. 2009
    ..The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21...
  39. doi MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    Yiming Li
    Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
    Brain Res 1286:13-8. 2009
    ..Our findings suggest that miR-21 represents a promising target for therapeutic manipulation to increase the efficacy of chemotherapeutic agents in treating glioblastoma, a highly lethal type of cancer...
  40. ncbi MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    Ruirui Ji
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Circ Res 100:1579-88. 2007
    ..MiRNAs may be a new therapeutic target for proliferative vascular diseases such as atherosclerosis, postangioplasty restenosis, transplantation arteriopathy, and stroke...
  41. pmc MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  42. ncbi MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    I A Asangani
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, Germany
    Oncogene 27:2128-36. 2008
    ..This is the first study to show that Pdcd4 is negatively regulated by miR-21. Furthermore, it is the first report to demonstrate that miR-21 induces invasion/intravasation/metastasis...
  43. ncbi miR-21 microRNA expression in human gastric carcinomas and its clinical association
    Shih Hsuan Chan
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Republic of China
    Anticancer Res 28:907-11. 2008
    ..However, its association with the clinicopathological features of human gastric cancer has yet to be addressed...
  44. pmc MicroRNA alterations in head and neck squamous cell carcinoma
    Steven S Chang
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0910, USA
    Int J Cancer 123:2791-7. 2008
    ..These differentially expressed microRNAs may be of interest as potential novel oncogenes and tumor suppressor genes in HNSCC. Mir-21 is a putative oncogenic microRNA in head and neck cancer...
  45. pmc MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    Li Xu Yan
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou 510060, People s Republic of China
    RNA 14:2348-60. 2008
    ....
  46. doi High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1
    Biyun Qian
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 117:131-40. 2009
    ..08-4.00) despite no value for prognosis. The study supports the notion that miR-21 is an onco-microRNA for breast cancer. Elevated miR-21 expression may facilitate tumor progression, and TGF-beta may up-regulate its expression...
  47. pmc Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
    Nalinie S Wickramasinghe
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 37:2584-95. 2009
    ..These results are the first to demonstrate that E(2) represses the expression of an oncogenic miRNA, miR-21, by activating estrogen receptor in MCF-7 cells...
  48. doi Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression
    Redouane Rouas
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Bruxelles, Belgium
    Eur J Immunol 39:1608-18. 2009
    ..In conclusion, not only have we identified and validated a miR signature for human natural Treg, but also unveiled some of the mechanisms by which this signature was related to the control of FOXP3 expression in these cells...
  49. pmc microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells
    Peng Wang
    Departments of Pathology and Pharmacology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 69:8157-65. 2009
    ..Our data show a role of miR-21 in modulating cell cycle progression following stress, providing a novel mechanism of Cdc25A regulation and a potential explanation of miR-21 in tumorigenesis...
  50. doi Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    Frederick J Sheedy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:141-7. 2010
    ..Thus, miR-21 regulates PDCD4 expression after LPS stimulation...
  51. pmc MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol
    Yu Ren
    Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, PR China
    BMC Cancer 10:27. 2010
    ..Thus, miR-21 can theoretically become a target to enhance the chemotherapeutic effect in cancer therapy. So far, the effect of downregulating miR-21 to enhance the chemotherapeutic effect to taxol has not been studied in human GBM...
  52. pmc MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity
    Martina Weber
    Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 393:643-8. 2010
    ..These studies advance our understanding of the mechanisms by which shear stress forces modulate vascular homeostasis...
  53. doi MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
    Ji Guang Zhang
    Thoracic Surgery Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People s Republic of China
    Clin Chim Acta 411:846-52. 2010
    ..We identified the role of miR-21 in non-small cell lung cancer (NSCLC) and to clarify the regulation of PTEN by miR-21 and determine mechanisms of this regulation...
  54. pmc MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
    Bao Song
    Provincial Key Laboratory of radiation oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
    J Exp Clin Cancer Res 29:29. 2010
    ....
  55. pmc MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
    Danish Sayed
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 285:20281-90. 2010
    ..Thus, we have identified a unique aspect of the function of AKT by which it inhibits apoptosis through miR-21-dependent suppression of FasL...
  56. ncbi Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC
    Sotai Kimura
    Division of Tumor Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Oncol Rep 23:1625-33. 2010
    ..These results suggest that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in HNSCC and ESCC...
  57. doi MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma
    Changzheng Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Department of Biochemistry, Beijing, PR China
    J Hepatol 53:98-107. 2010
    ..In this study, we investigate the function of microRNA-21 as a potent oncomir and probe the relationship between microRNA-21, its targets, and phenotypic alterations...
  58. doi Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    Felix Fleissner
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Circ Res 107:138-43. 2010
    ..The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (APCs) by small regulatory RNAs...
  59. pmc Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta
    Matthew A Maccani
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 5:583-9. 2010
    ..These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression...
  60. pmc miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells
    Charisa L Cottonham
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:35293-302. 2010
    ..Therefore, we have uncovered miR-21 and miR-31 as downstream effectors of TGF-β in facilitating invasion and metastasis of colon carcinoma cells...
  61. doi NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors
    Vivian Y Shin
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Carcinogenesis 32:240-5. 2011
    ..Perhaps this study may shed light on the development of anticancer drugs to improve the chemosensitivity in smokers...
  62. doi Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis
    Jian Xu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Mol Carcinog 50:136-42. 2011
    ..Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC...
  63. doi Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer
    Hajime Shibuya
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Oncology 79:313-20. 2010
    ..In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined...
  64. doi microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells
    Jun Tao
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, PR China
    Oncol Rep 25:1721-9. 2011
    ..Furthermore, the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002. These data verified the oncogenic role of miR-21 in TCCs and may usher in new therapeutic strategies in treating this disease...
  65. doi Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis
    Xiaonan Fu
    Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China
    Eur J Clin Invest 41:1245-53. 2011
    ..The aim of this meta-analysis is to summarize the global predicting role of miR-21 for survival in patients with a variety of carcinomas...
  66. doi Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
    Elias Stagakis
    Laboratory of Autoimmunity and Infl ammation, University of Crete Medical School, Heraklion, Greece
    Ann Rheum Dis 70:1496-506. 2011
    ..A study was undertaken to characterise the miRNA signature and identify novel genes involved in the regulation of immune responses in systemic lupus erythematosus (SLE)...
  67. doi A miR-21 inhibitor enhances apoptosis and reduces G(2)-M accumulation induced by ionizing radiation in human glioblastoma U251 cells
    Yi Li
    Department of Neurosurgery, Kansai Medical University, Moriguchi, Osaka 570 8507, Japan
    Brain Tumor Pathol 28:209-14. 2011
    ..Taken together, these findings suggest that miR-21 inhibitor can increase IR-induced growth arrest and apoptosis in U251 glioblastoma cells, at least in part by abrogating G(2)-M arrest, and that Cdc25A is a potential target of miR-21...
  68. doi Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Hepatol 56:167-75. 2012
    ..The aim of this study was to evaluate the significance of plasma microRNA-21 level as a biochemical marker for hepatocellular carcinoma...
  69. pmc Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors
    Kyriaki Bakirtzi
    Division of Digestive Diseases, Inflammatory Bowel Disease Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Gastroenterology 141:1749-61.e1. 2011
    ..MicroRNAs (miR) regulate protein synthesis by degrading or preventing translation of mRNAs. We analyzed expression of 365 different microRNAs by human colonic epithelial cells (NCM460) after activation of NTR1...
  70. pmc MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity
    Thomas X Lu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 187:3362-73. 2011
    ..Thus, our results define miR-21 as a major regulator of Th1 versus Th2 responses, defining a new mechanism for regulating polarized immunoinflammatory responses...
  71. pmc miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions
    V Grignol
    Department of Surgery, The Ohio State University Comprehensive Cancer Center, N924 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA
    Br J Cancer 105:1023-9. 2011
    ....
  72. doi miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells
    Ming Liu
    Department of Medical Oncology Laboratory of Signal Transduction and Molecular Targeted Therapy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    FEBS Lett 585:2998-3005. 2011
    ..These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer...
  73. pmc Prognostic significance of miR-181b and miR-21 in gastric cancer patients treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin
    Jingting Jiang
    Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People s Republic of China
    PLoS ONE 6:e23271. 2011
    ..Doxifluridine/Oxaliplatin regimen and to identify miRNAs as potential prognostic biomarkers in gastric cancer patients. The expression of candidate miRNAs was quantified from fifty-five late stage gastric cancer FFPE specimens...
  74. doi Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma
    Yuichi Nagao
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Mod Pathol 25:112-21. 2012
    ....
  75. doi Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells
    Mingli Han
    Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Mol Cell Biochem 363:427-36. 2012
    ..Our results demonstrated that re-expression of miR-21 is responsible for migration and invasion by activating the EMT process and enhancing the characteristics of CSCs in MCF-7 cells...
  76. doi Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
    Petra Faltejskova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic
    Int J Colorectal Dis 27:1401-8. 2012
    ..MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer (CRC) patients; however, only a little is known about its functional role in CRC...
  77. pmc EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours
    Olga Bornachea
    Molecular Oncology Unit, CIEMAT, Ave Complutense 40, E 28040 Madrid, Spain
    Sci Rep 2:434. 2012
    ..Collectively these data identify novel molecular mechanisms leading to metastasis in vivo originated by p53 loss in epithelia...
  78. pmc Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    Mingli Han
    Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    PLoS ONE 7:e39520. 2012
    ....
  79. pmc TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e42316. 2012
    ..Our results uncover an essential role of TGFβ-induced expression of miR-21, which targets PTEN to initiate a non-canonical signaling circuit involving Akt/mTORC1 axis for mesangial cell hypertrophy and matrix protein synthesis...
  80. doi Effect of miR-21 and miR-30b/c on TRAIL-induced apoptosis in glioma cells
    C Quintavalle
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples, Italy
    Oncogene 32:4001-8. 2013
    ..In conclusion, we show that high expression levels of miR-21 and -30b/c are needed to maintain the TRAIL-resistant phenotype, thus making these miRs as promising therapeutic targets for TRAIL resistance in glioma...
  81. doi Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Mech Ageing Dev 133:675-85. 2012
    ..TGF-βR2 mRNA, a validated miR-21 target, showed the highest expression in the leukocytes from a subset of the octogenarians. Our findings suggest that miR-21 may be a new biomarker of inflammation...
  82. pmc Mechanical stretch modulates microRNA 21 expression, participating in proliferation and apoptosis in cultured human aortic smooth muscle cells
    Jian Tao Song
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e47657. 2012
    ..We tested whether the expression of microRNA 21 (miR-21) is modulated by stretch and is involved in stretch-induced proliferation and apoptosis of human aortic smooth muscle cells (HASMCs)...
  83. doi The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL
    Peng Wang
    Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China
    Mol Oncol 7:334-45. 2013
    ..Therefore, the serum level of miR-21 may serve as a predictor of chemosensitivity in advanced pancreatic cancer. Additionally, we identified a new mechanism of chemoresistance mediated by the effects of miR-21 on the FasL/Fas pathway...
  84. ncbi Prognostic impact of circulating miR-21 in the plasma of patients with gastric carcinoma
    Shuhei Komatsu
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachihirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Anticancer Res 33:271-6. 2013
    ..Recently, we reported that these miRNAs were consistently detectable in plasma and reflected tumor dynamics of GC. We hypothesized that these plasma miRNA concentrations could be used as prognostic markers in patients with GC...
  85. pmc miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling
    Tushar D Bhagat
    Albert Einstein College of Medicine, Bronx, NY
    Blood 121:2875-81. 2013
    ..Taken together, these studies demonstrate the role of miR-21 in regulating overactivated TGF-β signaling in MDS...
  86. pmc Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth
    Emanuela Leone
    Medical Oncology Unit, Department of Experimental and Clinical Medicine, Magna Graecia University and T Campanella Cancer Center, Catanzaro, Italy
    Clin Cancer Res 19:2096-106. 2013
    ..Among upregulated miRNAs, miR-21 has oncogenic potential and therefore represents an attractive target for the treatment of multiple myeloma...
  87. pmc Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth
    Yan Xia Zhang
    Key Laboratory of Tumour Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, China
    Biomed Pharmacother 67:97-102. 2013
    ..Our results demonstrated that cisplatin could upregulate the expression of MSH2 through downregulating miR-21 to inhibit A549 cell proliferation, which provides new gene targets for drug design or cancer therary...
  88. pmc High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan
    Hanna Dellago
    Department of Biotechnology, BOKU VIBT University of Natural Resources and Life Sciences Vienna, Muthgasse 18, 1190, Vienna, Austria
    Aging Cell 12:446-58. 2013
    ..Therefore, we propose that miR-21 is the first miRNA that upon its knock-down extends the replicative lifespan of normal human cells...
  89. pmc Plasma miRNAs as biomarkers to identify patients with castration-resistant metastatic prostate cancer
    Akira Watahiki
    The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC V6H 3Z6, Canada
    Int J Mol Sci 14:7757-70. 2013
    ..Our results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC...
  90. doi Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer
    Guang Hui Liu
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, China
    Tumour Biol 34:2175-81. 2013
    ..In summary, our data indicate that miR-21 and miR-92a serum levels have potential value for early detection of CRC. Furthermore, miR-92a has prognostic value in CRC patients...
  91. doi The prognostic significance of APC gene mutation and miR-21 expression in advanced-stage colorectal cancer
    T H Chen
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan Division of Gastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Colorectal Dis 15:1367-74. 2013
    ..The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients...
  92. doi Let-7g and miR-21 expression in non-small cell lung cancer: correlation with clinicopathological and molecular features
    Alessandra Capodanno
    Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, I 56126 Pisa, Italy
    Int J Oncol 43:765-74. 2013
    ..Our data indicate that Let-7g and miR-21 profiling combined with the determination of K-Ras mutational status may be considered a useful biomarker for a more effective molecular characterization and clinical management of NSCLC patients...
  93. ncbi Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells
    Hugo Seca
    Cancer Drug Resistance Group, IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Curr Drug Targets 14:1135-43. 2013
    ..To the best of our knowledge, this is the first description of autophagy induction via miR-21 targeting and its involvement in drug sensitivity. ..
  94. pmc MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis
    Brian E Kadera
    Division of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e71978. 2013
    ..Dysregulation of miR regulatory networks in PDAC tumor-associated fibroblasts (TAFs) have not been previously described. In this study, we show that miR-21 expression in TAFs promotes TC invasion...
  95. doi Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells
    Fei Luo
    Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, PR China The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, PR China
    Toxicol Appl Pharmacol 273:27-34. 2013
    ..These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. ..
  96. pmc Potential role of microRNA-21 in the diagnosis of gastric cancer: a meta-analysis
    Zongyue Zeng
    College of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chong Qing Medical University, Chongqing, China
    PLoS ONE 8:e73278. 2013
    ..Therefore, we aimed to assess the potential diagnostic value of miR-21 for gastric cancer in this study...
  97. doi MicroRNA-21 in breast cancer: diagnostic and prognostic potential
    J Chen
    Department of Medical Oncology Breast, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, 310022, Zhejiang, China
    Clin Transl Oncol 16:225-33. 2014
    ..We will also discuss the issues and challenges of miR-21 as a potential biomarker in future clinical applications. ..
  98. pmc Prognostic role of microRNA-21 in colorectal cancer: a meta-analysis
    Xiaochun Xia
    Department of Radiation Oncology, Nantong Tumor Hospital, Nantong, Jiangsu, China
    PLoS ONE 8:e80426. 2013
    ..The present meta-analysis summarizes the recent advances in the use of microRNA-21 (miR-21) in the assessment of colorectal cancer and analyzes the prognostic role of miR-21 for survival outcome...
  99. doi MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
    Z Lu
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Oncogene 27:4373-9. 2008
    ..The demonstration that miR-21 promotes cell transformation supports the concept that mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4...
  100. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
    ..995. Inhibitors of miR-21 increased protein levels of programmed cell death 4 (PDCD4) and tissue inhibitor of metalloproteinases 3 (TIMP3). Notably, messenger RNA levels of TIMP3 were significantly lower in CCAs than in normals...
  101. doi MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen
    Haitao Bai
    Department of Haematology, Shanghai Jiaotong University Affiliated Shanghai First People s Hospital, Shanghai, China
    Int J Hematol 97:223-31. 2013
    ..Furthermore, knockdown of NF-κB decreased miR-21 expression and sensitized CRL2631 cells to CHOP treatment. These results provide evidence that it may be possible to overcome microRNA-based DLBCL drug resistance...

Research Grants5

  1. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  2. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  3. CONTROL OF DIFFERENTIATION IN COLON CARCINOMA
    Luzhe Sun; Fiscal Year: 2001
    ....
  4. Role of BCL-6 in Allergic Immune Responses
    Alexander Dent; Fiscal Year: 2005
    ..These studies will also provide insight into the function of BCL6, which may help the treatment of B cell lymphoma. ..
  5. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..