MIR200A

Summary

Gene Symbol: MIR200A
Description: microRNA 200a
Alias: MIRN200A
Species: human

Top Publications

  1. pmc miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    Jonathon D Roybal
    University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cancer Res 9:25-35. 2011
  2. doi miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
    Bogdan Mateescu
    Stress and Cancer Laboratory, Institut Curie, Paris, France
    Nat Med 17:1627-35. 2011
  3. doi Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer
    Niall Barron
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Prostate 72:1193-9. 2012
  4. doi MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2
    Qiuhua Wu
    Department of Obstetrics and Gynaecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China
    Gynecol Oncol 122:149-54. 2011
  5. doi Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer
    Erik D Wiklund
    Department of Molecular Biology, Aarhus University, Aarhus C, Denmark
    Int J Cancer 128:1327-34. 2011
  6. pmc Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway
    Okay Saydam
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts 02129, USA
    Mol Cell Biol 29:5923-40. 2009
  7. doi A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer
    Xiaoxia Hu
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 114:457-64. 2009
  8. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
  9. doi Loss of microRNA-200a expression correlates with tumor progression in breast cancer
    Kiseok Jang
    Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea Electronic address
    Transl Res 163:242-51. 2014
  10. pmc Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
    Miharu Kobayashi
    Centre for Clinical Diagnostics, Royal Brisbane and Women s Hospital, University of Queensland Centre for Clinical Research, Building 71 918, Herston, Queensland 4029, Australia
    J Transl Med 12:4. 2014

Scientific Experts

  • Carlos Salomon
  • Koichi Yoneyama
  • Guo sheng Gao
  • En Min Li
  • Qingmin Sun
  • ROBERT CASERO
  • Sriram Venneti
  • Anna Torres
  • Liana Adam
  • Nina Zidar
  • Mingyan Zhu
  • Ki Seok Jang
  • N Barron
  • Gabriel Eades
  • Hongping Xia
  • Xiaoxia Hu
  • Jianlin Wang
  • Xisheng Yang
  • Chin Sheng Hung
  • Jonathon D Roybal
  • Mohammed A Suliman
  • X Tang
  • Vin Yee Chung
  • Xiaoxia Sun
  • Zhuliang Shi
  • Daniel Senfter
  • Yuan Gao
  • Zhenduo Lu
  • Chong Zhong
  • Haimin Li
  • Xiaojie Bian
  • Jiye Feng
  • Mónica Martínez-Fernández
  • Bai Ruan
  • Lindsey E Becker
  • Shibin Qu
  • Kefeng Dou
  • Tadashi Asakura
  • Jia Yao
  • Xiaofeng Xue
  • C Bernecker
  • Cheng liang Zhu
  • M Pichler
  • Miharu Kobayashi
  • Rong Li
  • Christine M O'Connor
  • Yolande Berthois
  • Yuhang Su
  • Evgeny Izumchenko
  • P Ceppi
  • Limo Chen
  • Shaohua Xu
  • Shuet Theng Lee
  • Xiaoyan Liao
  • Yat Yuen Lim
  • Yong Li
  • Po Li Wei
  • San Jian Yu
  • Ningning Cong
  • Hung Hua Liang
  • Gerben Duns
  • David H Engelsvold
  • Maricica Pacurari
  • Yu Jia Chang
  • Suhail Ahmed Kabeer Rasheed
  • Jonathan M Kurie
  • Don L Gibbons
  • Young Ho Ahn
  • John V Heymach
  • Yingwei Chen
  • Koriand r C Williams
  • Jiping Cai
  • Sripathi M Sureban
  • Ji Hang Yuan
  • Yuan Yao
  • Susanna Leskela
  • Muhua Yang
  • Erik D Wiklund
  • Yi Xuan Li
  • Qiuhua Wu
  • Qun Zhou
  • Tissa T Manavalan
  • Bogdan Mateescu
  • Yong Huang
  • Yongshu Zhang
  • Johnny Sze
  • Xiu Wu Bian
  • Marie C Lin
  • S Uhlmann
  • Ang Li

Detail Information

Publications70

  1. pmc miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    Jonathon D Roybal
    University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cancer Res 9:25-35. 2011
    ..Flt1 knockdown decreased the growth and metastasis of tumor cells in syngeneic mice. We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1...
  2. doi miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
    Bogdan Mateescu
    Stress and Cancer Laboratory, Institut Curie, Paris, France
    Nat Med 17:1627-35. 2011
    ..The miR200a-dependent stress signature correlates with improved survival of patients in response to treatment...
  3. doi Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer
    Niall Barron
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Prostate 72:1193-9. 2012
    ..MicroRNA (miRNA) levels are altered in cancer and are associated with progression of disease. The miR-200 family has roles in prostate cancer...
  4. doi MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2
    Qiuhua Wu
    Department of Obstetrics and Gynaecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China
    Gynecol Oncol 122:149-54. 2011
    ..The aim of the study was to elucidate the mechanism of miR-200a involved in migration and invasion in CD133/1+ ovarian cancer stem cells (OCSCs)...
  5. doi Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer
    Erik D Wiklund
    Department of Molecular Biology, Aarhus University, Aarhus C, Denmark
    Int J Cancer 128:1327-34. 2011
    ..TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression...
  6. pmc Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway
    Okay Saydam
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts 02129, USA
    Mol Cell Biol 29:5923-40. 2009
    ....
  7. doi A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer
    Xiaoxia Hu
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 114:457-64. 2009
    ..A reliable method that could predict disease outcome would improve care of patients with this disease. The main aim of this study is to identify novel prognostic biomarkers for advanced ovarian cancer...
  8. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. Our data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells...
  9. doi Loss of microRNA-200a expression correlates with tumor progression in breast cancer
    Kiseok Jang
    Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea Electronic address
    Transl Res 163:242-51. 2014
    ..ISH can be used to detect miRNAs in FFPE sections, and should permit the validation of miRNAs as biomarkers in large clinical samples. ..
  10. pmc Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
    Miharu Kobayashi
    Centre for Clinical Diagnostics, Royal Brisbane and Women s Hospital, University of Queensland Centre for Clinical Research, Building 71 918, Herston, Queensland 4029, Australia
    J Transl Med 12:4. 2014
    ..The hypothesis to be tested was that ovarian cancer cell invasiveness is associated with altered release of exosomes and discordant exosomal sequestration of miRNA...
  11. doi MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN
    Rong Li
    Laboratory of Reproductive Biology, Chongqing Medical University, No 1 Yixueyuan Rd, Box 197, Chongqing, 400016, People s Republic of China
    Mol Biol Rep 41:1977-84. 2014
    ..Taken together, we propose that in HEC-1B cells, miR-200a functions as an oncogene, affecting proliferation and apoptosis by regulating the expression of the tumor suppressor PTEN at the translational level...
  12. pmc Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions
    Xiaoyan Liao
    Department of Reproductive Medicine, University of California, San Diego, California, USA
    J Cell Sci 126:3848-61. 2013
    ..These findings suggest that precise control of target mRNA expression by miRNAs ensures proper lineage specification during pancreatic development. ..
  13. pmc MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients
    M Pichler
    1 Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria 2 Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Br J Cancer 110:1614-21. 2014
    ..In this study, we therefore globally profiled miRNAs associated with E-cadherin expression in CRC cells in an attempt to identify miRNAs that are associated with aggressive clinical course in CRC patients...
  14. doi microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases
    C Bernecker
    Division for Endocrinology, Department of Endocrinology and Diabetes, Medical Faculty, Heinrich Heine University Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 122:107-12. 2014
    ..These data may help to better understand the gene regulations in the causative cells causing these autoimmune processes. They extend our very limited knowledge concerning miRNAs in thyroid diseases. ..
  15. ncbi The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features
    Shaohua Xu
    Department of Biomedical Science, Mercer University School of Medicine, Savanna, GA 31410, USA Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China
    Curr Pharm Des 20:1888-95. 2014
    ....
  16. pmc Host microRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency
    Christine M O'Connor
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Virol 88:5524-32. 2014
    ..Cells permissive for lytic replication demonstrate low levels of these miRNAs. We propose that cellular miRNA regulation of HCMV is critical for maintenance of viral latency...
  17. doi microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer
    Jia Yao
    1 Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China
    DNA Cell Biol 33:291-300. 2014
    ....
  18. pmc Differential expression of miR200a-3p and miR21 in grade II-III and grade IV gliomas: evidence that miR200a-3p is regulated by O⁶-methylguanine methyltransferase and promotes temozolomide responsiveness
    Yolande Berthois
    Aix Marseille Université Inserm CRO2 UMR_S 911 Marseille, France
    Cancer Biol Ther 15:938-50. 2014
    ..oncogenic miR21 has been shown to be overexpressed in gliomas, the expression and function of the tumor-supressor miR200a in GBMs remains unknown. In this study, we show that miR21 is upregulated in grade IV (GBMs) vs...
  19. pmc The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors
    Evgeny Izumchenko
    Authors Affiliations Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine and
    Cancer Res 74:3995-4005. 2014
    ....
  20. pmc The role of miR-200a in mammalian epithelial cell transformation
    Lindsey E Becker
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Carcinogenesis 36:2-12. 2015
    ..These results demonstrate an oncogenic role for miR-200a and provide a specific cellular context where miR-200a acts as an oncomiR rather than a tumor suppressor by cooperating with an oncogene in malignant cell transformation. ..
  21. pmc MiR200-upregulated Vasohibin 2 promotes the malignant transformation of tumors by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
    Xiaofeng Xue
    Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China
    Cell Commun Signal 12:62. 2014
    ..Previously, we reported that Vasohibin2 (VASH2) is preferentially expressed in hepatocellular carcinoma (HCC) tumor tissues and promotes angiogenesis. Here, we further investigated the role of VASH2 in HCC tumor progression...
  22. doi MiR-200a impairs glioma cell growth, migration, and invasion by targeting SIM2-s
    Yuhang Su
    Departments of aEmergency Surgery bNeurosurgery, Qilu Hospital of Shandong University cBrain Science Research Institute, Shandong University, Jinan dDepartment of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao Medical College, Yantai, China
    Neuroreport 25:12-7. 2014
    ..Finally, blockage of miR-200a expression in a mouse model of human glioma resulted in significant promotion of tumor growth. These findings suggest that miR-200a could serve as a therapeutic tool for glioma. ..
  23. doi Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis
    Xiaoxia Sun
    Department of Cardiology 3, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P R China
    Int J Mol Med 38:1303-11. 2016
    ....
  24. pmc Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    Limo Chen
    1 Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Commun 5:5241. 2014
    ....
  25. ncbi miR-200a overexpression in advanced ovarian carcinomas as a prognostic indicator
    Cheng liang Zhu
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China E mail
    Asian Pac J Cancer Prev 15:8595-601. 2014
    ..miR-200a expression is frequently altered in numerous cancers. The aim of the present study was to determine the role of microRNA-200a in advanced ovarian carcinomas...
  26. doi Overexpression of miR-200a suppresses epithelial-mesenchymal transition of liver cancer stem cells
    Jianlin Wang
    Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 West Changle Street, Xi an, Shaan Xi, 710032, People s Republic of China
    Tumour Biol 36:2447-56. 2015
    ....
  27. doi miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma
    Jiye Feng
    Department of Hepatobiliary Surgery, Ningbo Yinzhou People s Hospital Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, Zhejiang 315040, P R China
    Oncol Rep 33:713-20. 2015
    ..These findings suggest that miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation...
  28. doi Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1
    Tadashi Asakura
    Department of Biochemistry, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Int J Oncol 46:2251-60. 2015
    ..Since suppression of ZEB1 in Ish/EXM cells by treatment with its siRNA did not restore the miR-200 family expression, miR-200 family was placed upstream of ZEB1 to regulate the expression...
  29. pmc Expression of dicer and its related miRNAs in the progression of prostate cancer
    Xiaojie Bian
    Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 10:e0120159. 2015
    ....
  30. pmc MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
    Xisheng Yang
    Department of Hepatobiliary Surgery, The Xijing Hospital of The Fourth Military Medical Uiversity, Xi an, China
    Oncotarget 6:7918-29. 2015
    ..The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2...
  31. doi Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro
    Daniel Senfter
    Institute of Clinical Pathology and
    Hum Mol Genet 24:3689-98. 2015
    ..The data support the notion that horizontal miR-200 signalling prevents the permeation of cells into adjacent epithelia and contributes to organ integrity. ..
  32. pmc Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast cancer cells through upregulating mir-200a/b expression via association with p73
    Zhenduo Lu
    Department of Breast Surgery, Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, Henan, 450008, People s Republic of China
    Mol Cancer 14:102. 2015
    ..However, little information is available on its expression patterns and functions in vivo. Our study was performed to detect if Restin plays a role in breast cancer cells in vitro and in vivo...
  33. pmc Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling
    X Tang
    Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, 1 Yi Xue Yuan Road, Yu Zhong District, Chongqing 400016, China
    Cell Death Differ 23:132-45. 2016
    ..Thus, these data provide important and novel insights into breast CAF activation and ECM remodeling, which trigger tumor cell invasion...
  34. pmc A Polycomb-mir200 loop regulates clinical outcome in bladder cancer
    Mónica Martínez-Fernández
    Molecular Oncology Unit, CIEMAT ed70A, 28040 Madrid, Spain
    Oncotarget 6:42258-75. 2015
    ..Since pharmacological inhibition of EZH2 in BC cell lines lead to increased miR-200 expression, our findings may support new therapeutic strategies for BC clinical management. ..
  35. pmc MicroRNA-200a inhibits epithelial-mesenchymal transition in human hepatocellular carcinoma cell line
    Chong Zhong
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou 510405, P R China
    Int J Clin Exp Pathol 8:9922-31. 2015
    ..Our study investigated the role of microRNA (miR)-200a and its molecular targets in hepatocellular carcinoma (HCC) cells...
  36. doi MicroRNA-200a mediates nasopharyngeal carcinoma cell proliferation through the activation of nuclear factor-κB
    Zhuliang Shi
    Department of Ear, Nose and Throat, People s Liberation Army 113th Hospital, Ningbo, Zhejiang 315000, P R China
    Mol Med Rep 13:1732-8. 2016
    ..The luciferase assay indicated that IκBα was the target gene of miR-200a. In conclusion, miR-200a was demonstrated to enhance NPC cell proliferation by activating the NF-κB signaling pathway...
  37. pmc GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
    Vin Yee Chung
    Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, 12 01, Singapore 117599
    Sci Rep 6:19943. 2016
    ..These findings support GRHL2 as a pivotal gatekeeper of EMT in EOC via miR-200-ZEB1...
  38. pmc Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family
    Mohammed A Suliman
    Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P R China
    Int J Mol Med 38:776-84. 2016
    ..Collectively, these findings demonstrate that niclosamide potentially inhibits the progression of colon cancer by downregulating Notch signaling and by upregulating the miR-200 family members. ..
  39. pmc The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
    Maricica Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26505, USA
    Int J Oncol 43:548-60. 2013
    ..These results provide new insights into miR-200 regulation in lung cancer metastasis and consequent clinical outcome, and may provide a potential basis for innovative therapeutic approaches for the treatment of this deadly disease...
  40. doi MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells
    P Ceppi
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Oncogene 33:269-78. 2014
    ..This review will highlight and discuss this link and its possible implications for the fight against cancer. ..
  41. doi MicroRNA-200a and -200b mediated hepatocellular carcinoma cell migration through the epithelial to mesenchymal transition markers
    Chin Sheng Hung
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Ann Surg Oncol 20:S360-8. 2013
    ..However, little is known about specific miRNAs during the development of hepatocellular carcinoma (HCC) from well-differentiated to poorly differentiated cells...
  42. doi MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells
    Hung Hua Liang
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Tumour Biol 34:3209-18. 2013
    ..The expression levels of miR-200a/b might determine the therapeutic efficacy of curcumin on HCC cells...
  43. pmc miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium
    David H Engelsvold
    Department of Ophthalmology, Stavanger University Hospital, Stavanger, Norway Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, Bergen, Norway
    Exp Eye Res 115:189-98. 2013
    ....
  44. doi Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state
    Yat Yuen Lim
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    J Cell Sci 126:2256-66. 2013
    ..Therapy targeted against miR-200 family members and epigenetic modifications might therefore be applicable to breast cancer...
  45. doi MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Brain Pathol 22:522-9. 2012
    ..Our data suggest that miR-9 and miR-200a can distinguish between hemangioblastomas and Met CCRCC. Further, these results may also provide insight in understanding the biology of hemangioblastomas...
  46. doi miR-200a modulate HUVECs viability and migration
    Yi Xuan Li
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China
    IUBMB Life 63:553-9. 2011
    ..MiR-200a can directly bind to THBS1 3'UTR and negatively regulate THBS1 expression. The identification of endothelial cells (ECs) related miRNA and its target gene may gain new insight into the mechanism of angiogenesis...
  47. doi The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma
    Ji Hang Yuan
    Department of Medical Genetics, Second Military Medical University, Shanghai, China
    Hepatology 54:2025-35. 2011
    ..Finally, we determined that miR-200a inhibited the proliferation and migration of HCC cells in vivo and in vitro...
  48. pmc miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    Gabriel Eades
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:40725-33. 2011
    ....
  49. pmc Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells
    Tissa T Manavalan
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cancer Lett 313:26-43. 2011
    ..Agreement in the direction of anticipated regulation was detected for 12 putative targets. These miRNAs with opposite expression between the two cell lines may be involved in endocrine resistance...
  50. doi MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
    Yong Huang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    Blood 118:6793-802. 2011
    ..These data suggest that miR-132, -212, and -200a up-regulation during prolonged IL-12 treatment, negatively regulates the IL-12 signaling pathway by reducing STAT4 expression in primary human NK cells...
  51. pmc Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis
    Shuet Theng Lee
    Cancer Biology and Pharmacology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672
    Proc Natl Acad Sci U S A 110:11121-6. 2013
    ..We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC...
  52. doi MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2
    Jiping Cai
    Department of Ophthalmology of Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 250:523-31. 2012
    ..Aberrant microRNA expression is implicated in cancer initiation and progression. We sought to identify dysregulated miRNAs in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, and investigated their biological significance...
  53. pmc MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor
    Koriand r C Williams
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:7529-34. 2012
    ....
  54. doi Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients
    Anna Torres
    Laboratory of Biostructure, Department of Human Anatomy, Medical University of Lublin, Lublin, Poland
    Int J Cancer 132:1633-45. 2013
    ..909 (95% CI: 0.789-973) and 0.913 (95% CI: 0.794-0.976), respectively. We conclude that miRNA signatures hold a great promise to become noninvasive biomarkers for early EEC detection and prognosis...
  55. doi The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney
    Gerben Duns
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Genes Chromosomes Cancer 52:165-73. 2013
    ..Expression levels of 13 of the 47 validated target genes for the downregulated miRNAs were increased more than twofold. Our data reinforce the importance of the epithelial to mesenchymal transition process in the development of ccRCC...
  56. pmc MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells
    Suhail Ahmed Kabeer Rasheed
    Department of Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, 169857 Singapore
    J Biol Chem 288:7986-95. 2013
    ..These data provide strong evidence that GNA13 is an important mediator of prostate cancer cell invasion, and that miR-182 and miR-200 family members regulate its expression post-transcriptionally...
  57. doi MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer
    San Jian Yu
    Breast Cancer Institute, Department of Breast Surgery, Cancer Hospital Cancer Institute, Shanghai Medical College, Fudan University, Shanghai, PR China
    Clin Cancer Res 19:1389-99. 2013
    ..miR-200a is involved in this multistep metastatic cascade. This study aimed to test the hypothesis that miR-200a promotes metastasis through increased anoikis resistance in breast cancer...
  58. doi Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma
    Ningning Cong
    Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, PR China
    Oncol Rep 29:1579-87. 2013
    ..The effect of miR-200a on Wnt/β-catenin signaling may provide a therapeutic target against EMT...
  59. pmc miR-200b is involved in intestinal fibrosis of Crohn's disease
    Yingwei Chen
    Department of Gastroenterology, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, PR China
    Int J Mol Med 29:601-6. 2012
    ..Furthermore, we found that miR-200b was overexpressed in the serum of the fibrosis group. The results suggest that miR-200b has potential value for diagnostic and therapeutic applications for CD patients with fibrosis complications...
  60. doi miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy
    Liana Adam
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5060-72. 2009
    ..The aims of this study were to determine the potential role of microRNAs (miRNA) in controlling EMT and the role of EMT in inducing the sensitivity of human bladder cancer cells to the inhibitory effects of the anti-EGFR therapy...
  61. doi miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion
    Hongping Xia
    Integrative Chemical Biology Laboratory, Institute of Molecular Technology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Biochem Biophys Res Commun 391:535-41. 2010
    ..Our results reveal the important role of miR-200a as a regulatory factor of NPC carcinogenesis and a potential candidate for miRNA-based therapy against NPC...
  62. pmc A microRNA expression signature for cervical cancer prognosis
    Xiaoxia Hu
    Departments of Radiation Oncology, Pathology and Immunology, and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:1441-8. 2010
    ..In particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordinate suppression of multiple genes controlling cell motility...
  63. doi miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer
    S Uhlmann
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Oncogene 29:4297-306. 2010
    ..Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion, viability and cell cycle progression in breast cancer...
  64. pmc Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels
    Ang Li
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:5226-37. 2010
    ..The elevated serum levels of miR-200a and miR-200b in most patients with pancreatic cancer could have diagnostic utility...
  65. pmc miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling
    Hongping Xia
    Brain Tumour Centre and Division of Neurosurgery, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Biol Chem 285:36995-7004. 2010
    ....
  66. doi The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients
    Susanna Leskela
    Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Endocr Relat Cancer 18:85-95. 2011
    ..Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients...
  67. doi Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck--hallmark of epithelial-mesenchymal transition
    Nina Zidar
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
    Hum Pathol 42:482-8. 2011
    ..The result is not only an altered expression of classic cadherins in adherens junctions but also a complete loss of desmosomal cadherins...
  68. pmc DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
    Sripathi M Sureban
    Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 71:2328-38. 2011
    ..Moreover, they demonstrate a functional role for DCAMKL-1 in pancreatic cancer. Together, our results rationalize DCAMKL-1 as a therapeutic target for eradicating pancreatic cancers...
  69. pmc miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
    Gabriel Eades
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:25992-6002. 2011
    ....