MIR138-1

Summary

Gene Symbol: MIR138-1
Description: microRNA 138-1
Alias: MIRN138-1
Species: human

Top Publications

  1. pmc Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, Room 530C, Chicago, IL 60612, USA
    Hum Genet 129:189-97. 2011
  2. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
  3. doi MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer
    Huijun Zhang
    Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University, Shanghai
    Cell Physiol Biochem 31:56-65. 2013
  4. pmc miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL
    Valeska Berg
    Department I of Internal Medicine and Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Cologne, Germany
    Blood 125:2948-57. 2015
  5. doi MicroRNA138 regulates keratin 17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT in psoriasis vulgaris
    Shi Jun Feng
    Department of Dermatology, Cangzhou Central Hospital, Cangzhou 061001, PR China Electronic address
    Biomed Pharmacother 85:169-176. 2017
  6. doi MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha
    Xiong Wang
    Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    FEBS Lett 589:726-9. 2015
  7. doi MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX
    Huan Yang
    Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, 1
    Cancer Invest 33:126-36. 2015
  8. doi MiR-138/peroxisome proliferator-activated receptor β signaling regulates human hypertrophic scar fibroblast proliferation and movement in vitro
    Ying Ying Xiao
    Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China
    J Dermatol 42:485-95. 2015
  9. pmc Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer
    Yu Zhou Qin
    Department of Gastrointestinal Surgery, Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P R China
    Oncol Rep 33:2728-36. 2015
  10. pmc MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1
    Chao Yu
    Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, 550004, China
    Cell Oncol (Dordr) 38:173-81. 2015

Scientific Experts

  • Jirong Huo
  • B Li
  • Tao Song
  • Xiaofeng Zhou
  • Lu Jiang
  • Xiqiang Liu
  • Shi Jun Feng
  • Yun Wang
  • Li Ping Han
  • Kazuhiro Tanaka
  • Baoen Jiang
  • Christine I Seidl
  • Ziqiang Zhu
  • Jun Hu
  • Hélène Denis
  • Xiong Wang
  • Valeska Berg
  • Jiefang Li
  • Jin Wang
  • Ran Xu
  • Dandan Fu
  • Yu Zhou Qin
  • Liangping Wu
  • Chao Yu
  • Huan Yang
  • Ying Ying Xiao
  • Tian Yang
  • Anagha Sen
  • Yi Gao
  • Hui Yang
  • Bo Qu
  • Puxiang Chen
  • Lihong Han
  • Dongli Pan
  • Limin Long
  • Siyi He
  • Hui Gong
  • Shuwei Qiu
  • Huijun Zhang
  • Mrinmay Chakrabarti
  • Shyam Ramachandran
  • Ying Chu Lee
  • Takeshi Yamasaki
  • Andrew H Girgis
  • Xia Liu
  • Tilde Eskildsen
  • Yemin Wang
  • Anxun Wang
  • Guang Jing Zhang
  • Zheng Xiang Wang
  • Yun Yi Ma
  • Rui Qi Chu
  • Zhi Song
  • Jing Ma
  • Xiu Fang Yang
  • Shinichi Ikeda
  • Aida Martinez-Sanchez
  • Weimin Gao
  • Jianqiang Wang
  • Tatsuya Iwasaki
  • Haining Xu
  • Chao Wang
  • Ichiro Itonaga
  • Tian Fu
  • Masanori Kawano
  • Olivier Van Grembergen
  • Hongyan Tian
  • Rachel Deplus
  • Benjamin Delatte
  • Liang Li
  • Zebin Ma
  • Francois Fuks
  • Xiaoqing Zhou
  • Christopher L Murphy
  • Zhonglian Huang
  • Zhenzhen Sun
  • Gang Duan
  • Weidong Mu
  • Jiankun Xu
  • Yong Lin
  • Huanqiang Wang
  • Shou Lin Wang
  • Zhan Zhang
  • Hengsen Xu
  • Yuantao Zhang
  • Menglei Yu
  • Minghui Ji
  • Emilie Calonne
  • Jiangquan Wang
  • Qiu Fang Jiang

Detail Information

Publications45

  1. pmc Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, Room 530C, Chicago, IL 60612, USA
    Hum Genet 129:189-97. 2011
    ..In summary, we identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in TSCC initiation and progression...
  2. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
    ..Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis...
  3. doi MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer
    Huijun Zhang
    Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University, Shanghai
    Cell Physiol Biochem 31:56-65. 2013
    ..MicroRNAs (miRNAs) play important roles in tumorigenesis. We investigated the roles and mechanisms of miR-138 in human non-small cell lung cancer (NSCLC)...
  4. pmc miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL
    Valeska Berg
    Department I of Internal Medicine and Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Cologne, Germany
    Blood 125:2948-57. 2015
    ..Here, we introduce palmitoylation as a novel posttranslational modification in CLL, which might impact on localization, mobility, and function of molecules, survival signaling, and migration. ..
  5. doi MicroRNA138 regulates keratin 17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT in psoriasis vulgaris
    Shi Jun Feng
    Department of Dermatology, Cangzhou Central Hospital, Cangzhou 061001, PR China Electronic address
    Biomed Pharmacother 85:169-176. 2017
    ..MiR-138 may regulate K17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT gene...
  6. doi MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha
    Xiong Wang
    Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    FEBS Lett 589:726-9. 2015
    ..In conclusion, our data suggest that miR-138 promotes tau phosphorylation by targeting the RARA/GSK-3β pathway. ..
  7. doi MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX
    Huan Yang
    Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, 1
    Cancer Invest 33:126-36. 2015
    ..To date, there has been no study showing the role of miR-138/H2AX machinery in SCLC development. Our results may shed a light to development of new lines of SCLC diagnosis and treatment approaches. ..
  8. doi MiR-138/peroxisome proliferator-activated receptor β signaling regulates human hypertrophic scar fibroblast proliferation and movement in vitro
    Ying Ying Xiao
    Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China
    J Dermatol 42:485-95. 2015
    ..Thus, our study provides evidence to help determine whether miR-138/PPARβ signaling may be a potential target for hypertrophic scarring management. ..
  9. pmc Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer
    Yu Zhou Qin
    Department of Gastrointestinal Surgery, Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P R China
    Oncol Rep 33:2728-36. 2015
    ..The results indicated that miR-138-5p and miR-422a potentially inhibited hTERT expression in CRC, and suggest a potential application of miR‑422a in prognosis prediction and CRC treatment. ..
  10. pmc MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1
    Chao Yu
    Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, 550004, China
    Cell Oncol (Dordr) 38:173-81. 2015
    ..Here, we set out to investigate the role of microRNA 138 (miR-138-5p) in the regulation of pancreatic cancer cell growth and to assess its role as putative therapeutic target...
  11. doi Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus
    Liangping Wu
    Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
    APMIS 123:580-5. 2015
    ..Our study is one of the pioneer studies showing the differences in peripheral miRNA level in obesity, T2DM and T2DM combined with obesity. The study results suggest the potential utility of miRNAs in the prediction for obesity and T2DM. ..
  12. doi FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells
    Tian Yang
    Department of Respiratory Medicine, The First Affiliated Hospital, Medical College of Xi an Jiaotong University, 277 West Yanta Road, Xian, 710061, China
    Tumour Biol 36:8185-91. 2015
    ..Our data demonstrated that FOXP4 was a critical regulator in NSCLC and independently associated with miR-138 regulation...
  13. doi MicroRNA-138 regulates the balance of Th1/Th2 via targeting RUNX3 in psoriasis
    Dandan Fu
    Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453000, Henan, China
    Immunol Lett 166:55-62. 2015
    ..Taken together, our study suggests that increased miR-138 regulates the balance of Th1/Th2 through inhibiting RUNX3 expression in psoriasis, providing a potential therapeutic target for psoriasis. ..
  14. doi miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1
    Yun Wang
    Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, People s Republic of China
    Arch Toxicol 90:1239-49. 2016
    ..Still, the study provides a novel insight into the roles of miRNA* during carcinogenesis, particularly airborne carcinogens-induced lung cancer. ..
  15. doi MicroRNA-138 negatively regulates non-small cell lung cancer cells through the interaction with cyclin D3
    Li Ping Han
    Department of Respiratory Medicine, Jining First People s Hospital, 6 Jiankang Road, Jining, 272000, China
    Tumour Biol 37:291-8. 2016
    ..Our study revealed novel anti-cancer effects of miR-138 upregulation in NSCLC, as well as its new molecular target of CCND3. ..
  16. doi miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1
    Ran Xu
    Department of Stomatology, The First Affiliated Hospital, Medical School of Xi an Jiaotong University, Xi an, Shaanxi 710061, P R China
    Oncol Rep 34:2171-8. 2015
    ..The results suggest that miR-138 is a tumor suppressor miRNA in OSCC through targeting YAP1, which serves as a promising therapeutic target for the treatment of OSCC...
  17. pmc MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C
    Jiefang Li
    KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China
    J Cell Mol Med 19:2793-805. 2015
    ....
  18. doi Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype
    Christine I Seidl
    Kennedy Institute of Rheumatology and University of Oxford, Oxford, UK
    Arthritis Rheumatol 68:398-409. 2016
    ..To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs)...
  19. doi MicroRNAs regulate KDM5 histone demethylases in breast cancer cells
    Hélène Denis
    Laboratory of Cancer Epigenetics, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Biosyst 12:404-13. 2016
    ..Altogether, our findings suggest that miRNAs may regulate KDM5 histone demethylase levels in breast cancer and thereby control breast cancer cell proliferation and migration. ..
  20. doi Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cells
    Kazuhiro Tanaka
    Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Int J Oncol 48:1135-44. 2016
    ..The data in the present study demonstrates for the first time a novel mechanism that regulates the expression of FAK via miR‑138 in ES cells...
  21. pmc Focal Adhesion Kinase Signaling Mediated the Enhancement of Osteogenesis of Human Mesenchymal Stem Cells Induced by Extracorporeal Shockwave
    Jun Hu
    Department of Orthopaedics, The First Affiliated Hospital, Shantou University Medical College, Guangdong Province, China
    Sci Rep 6:20875. 2016
    ....
  22. pmc MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells
    Ziqiang Zhu
    Department of Orthopaedics, The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, China
    PLoS ONE 11:e0150026. 2016
    ..In conclusion, the present study demonstrates that miR-138 acts as a tumor suppressor by enhancing osteosarcoma cell chemosensitivity and supports its potential application for treating osteosarcoma in the future. ..
  23. ncbi MicroRNA-138 inhibits proliferation of cervical cancer cells by targeting c-Met
    B Li
    Harbin Medical University Cancer Hospital, Harbin, China
    Eur Rev Med Pharmacol Sci 20:1109-14. 2016
    ..MicroRNA-138 (miR-138) has been shown to play a critical role in tumor pathogenesis, the present study aimed to investigate the role of miR-138 in cervical cancer...
  24. pmc MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2
    Baoen Jiang
    Department of Traumatic Orthopaedics, The People s Hospital of Dongying City of Shandong Province, No 317 Nanyi Road, Dongying, 257091, Shandong, China
    J Exp Clin Cancer Res 35:69. 2016
    ..However, the expression and the role of miR-138 in human osteosarcoma are still poorly understood. We investigated the function and the underlying mechanism of miR-138 in osteosarcoma...
  25. doi Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling
    Puxiang Chen
    Department of Gynecology and Obstetrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P R China
    Oncol Rep 32:2070-6. 2014
    ..The results provide evidence supporting miR-138/Limk1 as a novel diagnostic or therapeutic target for ovarian cancer. ..
  26. doi Prognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer
    Lihong Han
    Department of Respiratory Medicine, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, 471009, Henan Province, China
    Med Oncol 31:129. 2014
    ..More importantly, miR-138 and PDK1 may synergistically predict patients' prognosis and their combination may represent a promising prognostic biomarker of human NSCLC...
  27. doi PDGF-regulated miRNA-138 inhibits the osteogenic differentiation of mesenchymal stem cells
    Bo Qu
    Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Department of Orthopaedics, Chengdu Military General Hospital, Chengdu, Sichuan Province, China
    Biochem Biophys Res Commun 448:241-7. 2014
    ....
  28. pmc A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency
    Dongli Pan
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell Host Microbe 15:446-56. 2014
    ..Thus, miR-138 is a neuronal factor that represses HSV-1 lytic gene expression, promoting host survival and viral latency. ..
  29. doi Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells
    Hui Yang
    Department of Nuclear Medicine, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, 450008, Henan, China
    Tumour Biol 35:6557-65. 2014
    ..In conclusion, our data demonstrate that the miR-138/SENP1 cascade is relative to radiosensitization in lung cancer cells and is a potential radiotherapy target. ..
  30. doi miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124
    Yi Gao
    Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Biochem Biophys Res Commun 446:179-86. 2014
    ....
  31. pmc Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction
    Anagha Sen
    Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA, USA
    FEBS Lett 588:906-14. 2014
    ..We show that loss of S100A1 in ECs reduces stimulus-induced NO production, which can be prevented by inhibition of miR-138. Our study suggests that targeting miR-138 might be beneficial for the treatment of cardiovascular disease. ..
  32. doi miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway
    Siyi He
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Biochem Biophys Res Commun 441:763-9. 2013
    ..Our study demonstrates that up-regulation of miR-138 plays a protective role in myocardial adaptation to chronic hypoxia, which is mediated mainly by MLK3/JNK/c-jun signaling pathway. ..
  33. pmc Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2
    Limin Long
    Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
    J Transl Med 11:275. 2013
    ..The molecular events involved in the development and progression of CRC remain unclear. Recently, more and more evidences have showed that deregulated miRNAs participate in colorectal carcinogenesis...
  34. doi Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions
    Jin Wang
    Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Lett 356:404-9. 2015
    ..Our findings make a compelling case for undertaking in-depth analyses of cyst fluid miRNomes for developing informative early detection biomarkers of pancreatic cancer developing from pancreatic cystic lesions...
  35. doi Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma
    Andrew H Girgis
    Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute St Michael s Hospital, Toronto, Canada
    Cancer Res 72:5273-84. 2012
    ....
  36. doi Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma
    Hui Gong
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Clin Cancer Res 19:1083-93. 2013
    ..Constitutive activation of NF-κB signaling plays vital roles in esophageal squamous cell carcinoma (ESCC) progression. The aim of this study was to evaluate the effect of miR-138 on NF-κB activation and ESCC progression...
  37. doi Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme
    Shuwei Qiu
    Department of Neurology, Sun Yat Sen University, Guangzhou, China
    Biochim Biophys Acta 1832:1697-707. 2013
    ..In conclusion, our data demonstrate a tumor suppressive role of miRNA-138 in GBM tumorigenicity, suggesting a potential application in GBM therapy...
  38. ncbi MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells
    Tao Song
    Department of Urology, Clinical Division of Surgery, Chinese PLA General Hospital, Beijing, China
    Asian Pac J Cancer Prev 12:1307-11. 2011
    ..Here, we investigated a microRNA regulating expression of HIF-1a and explored its functions in clear cell renal cell carcinoma (ccRCC) cells...
  39. doi MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene
    Xia Liu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cell Cycle 11:2495-506. 2012
    ..The identification of functional miR-138 in NPC and its direct link to CCND1 might provide good candidates for developing diagnostic markers and therapeutic applications for NPC...
  40. pmc Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma
    Takeshi Yamasaki
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Int J Oncol 41:805-17. 2012
    ..The existence of a tumor suppressive miR‑138-mediated oncogenic pathway provides new insights into the potential mechanisms of RCC oncogenesis and metastasis...
  41. pmc A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator
    Shyam Ramachandran
    Department of Pediatrics, Interdisciplinary Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 109:13362-7. 2012
    ..This discovery also provides therapeutic avenues for restoring CFTR function to cells affected by the most common cystic fibrosis mutation...
  42. pmc MicroRNA-138 suppresses neutrophil gelatinase-associated lipocalin expression and inhibits tumorigenicity
    Ying Chu Lee
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    PLoS ONE 7:e52979. 2012
    ..Taken together, our results indicate that NGAL may be a good target for cancer therapy and suggest that miR-138 acts as a tumor suppressor and may prevent metastasis...
  43. pmc miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo
    Mrinmay Chakrabarti
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA
    Exp Cell Res 319:1575-85. 2013
    ....
  44. pmc MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression
    Yemin Wang
    Howard Hughes Medical Institute, Division of Human Biology, University of Washington, Seattle, Washington, USA
    Mol Cancer Res 9:1100-11. 2011
    ..Our study suggests that miR-138 is an important regulator of genomic stability and a potential therapeutic agent to improve the efficacy of radiotherapy and chemotherapy with DNA-damaging agents...
  45. pmc MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
    Tilde Eskildsen
    Molecular Endocrinology Laboratory, KMEB, Odense University Hospital, University of South Denmark, DK 5000 Odense C, Denmark
    Proc Natl Acad Sci U S A 108:6139-44. 2011
    ..Our findings suggest that pharmacological inhibition of miR-138 by antimiR-138 could represent a therapeutic strategy for enhancing bone formation in vivo...