MIR137

Summary

Gene Symbol: MIR137
Description: microRNA 137
Alias: MIRN137, miR-137
Species: human

Top Publications

  1. doi MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A
    Kristina Althoff
    Department of Pediatric Oncology and Hematology, University Children s Hospital Essen, Essen, Germany
    Int J Cancer 133:1064-73. 2013
  2. doi Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia
    M J Green
    School of Psychiatry, University of New South Wales, Research Unit for Schizophrenia Epidemiology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Mol Psychiatry 18:774-80. 2013
  3. doi Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
    E Cummings
    Dept of Psychiatry and Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland
    Neurosci Lett 532:33-8. 2013
  4. pmc miR-137: a new player in schizophrenia
    Jingwen Yin
    Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China
    Int J Mol Sci 15:3262-71. 2014
  5. doi miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes
    Chonglin Luo
    Division of Translational Immunology D015, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Invest Dermatol 133:768-75. 2013
  6. pmc Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells
    Matthew J Hill
    Department of Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 153:225-30. 2014
  7. pmc A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137
    Paolo Devanna
    Language and Genetics Department, Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD, Nijmegen, The Netherlands
    Sci Rep 4:3994. 2014
  8. doi MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2
    Li Liang
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, PR China
    Gastroenterology 144:624-635.e4. 2013
  9. pmc Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer
    Dong Liang Chen
    State Key Laboratory of Oncology in South China
    Carcinogenesis 34:803-11. 2013
  10. pmc Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuropsychopharmacology 37:2720-9. 2012

Research Grants

Scientific Experts

  • Melissa Jayne Green
  • Jubao Duan
  • Emilia Kozlowska
  • Yingwei Luo
  • Yantao Du
  • Berrin Tunca
  • H C Whalley
  • Da Jun Deng
  • K Danielsson
  • Sjoukje I Lok
  • S G Potkin
  • M Svoboda
  • Chonglin Luo
  • Xiaolan Zhu
  • Scott M Langevin
  • Theo G M van Erp
  • Ilaria Guella
  • Astrid Vallès
  • C Wright
  • Hélène Denis
  • Yong Han
  • Joshua C Black
  • Jie Li
  • Ping Zhang
  • V I Loginov
  • Alix Warburton
  • Shuai Hao
  • Chao Tan
  • M Strazisar
  • Liyu Zhang
  • Yuecheng Zeng
  • Yan rong Yang
  • Amber R Smith
  • Yijun Yang
  • Shihui Xia
  • Yan Cheng
  • Matthew J Hill
  • Jingwen Yin
  • Peipei Li
  • Paolo Devanna
  • Sheng Liu
  • Youcheng Xiu
  • Fanglin Guan
  • Helena Cousijn
  • Keun Koo Shin
  • Saleh Tamim
  • Emma J Rose
  • Fabio Macciardi
  • Marquis P Vawter
  • Jun Dang
  • Hao Li
  • Wenlin Xu
  • Lulu Long
  • Ariel Bier
  • Lulu Hui
  • E Cummings
  • Kristina Althoff
  • T A Lett
  • Li Liang
  • Jinling Guo
  • Huiling Shen
  • Dong Liang Chen
  • Yuefeng Li
  • Armaz Aschrafi
  • Lingchao Chen
  • Yan Sun
  • Boryana Georgieva
  • Marjolein H Willemsen
  • Hirosha Geekiyanage
  • Qingjiang Chen
  • Xiaoyan Chen
  • Yu Deng
  • Robert W Sobol
  • Jennifer R Grandis
  • Clareann H Bunker
  • Emanuela Taioli
  • Roslyn A Stone
  • Lynne T Bemis
  • Gad Getz
  • V V Khokonova
  • S Ehrlich
  • Na Liu
  • Zhenlin Yang
  • Christos Sotiriou
  • Johnathan R Whetstine
  • Françoise Rothé
  • Chao Pan
  • Guoqiang Zhang
  • Hailei Zhang
  • J Chen

Detail Information

Publications68

  1. doi MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A
    Kristina Althoff
    Department of Pediatric Oncology and Hematology, University Children s Hospital Essen, Essen, Germany
    Int J Cancer 133:1064-73. 2013
    ..Therapeutic strategies to re-express miR-137 in neuroblastomas could be useful to reduce tumor aggressiveness. ..
  2. doi Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia
    M J Green
    School of Psychiatry, University of New South Wales, Research Unit for Schizophrenia Epidemiology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Mol Psychiatry 18:774-80. 2013
    ..Risk alleles on the MIR137 single-nucleotide polymorphism (SNP) predicted membership of CD subtype only in combination with higher severity ..
  3. doi Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
    E Cummings
    Dept of Psychiatry and Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland
    Neurosci Lett 532:33-8. 2013
    ..The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes...
  4. pmc miR-137: a new player in schizophrenia
    Jingwen Yin
    Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China
    Int J Mol Sci 15:3262-71. 2014
    ..A more complete picture of the miR-137, which is dysregulated in psychiatric illness, may improve our understanding of the molecular mechanisms underlying schizophrenia. ..
  5. doi miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes
    Chonglin Luo
    Division of Translational Immunology D015, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Invest Dermatol 133:768-75. 2013
    ..In summary, our study confirms that miR-137 acts as a tumor suppressor in malignant melanoma and reveals that miR-137 regulates multiple targets including c-Met, YB1, EZH2, and MITF...
  6. pmc Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells
    Matthew J Hill
    Department of Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 153:225-30. 2014
    b>MIR137, transcribed as the microRNA miR-137, is one of the leading candidate schizophrenia susceptibility genes to arise from large genome-wide association studies (GWAS) of the disorder...
  7. pmc A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137
    Paolo Devanna
    Language and Genetics Department, Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD, Nijmegen, The Netherlands
    Sci Rep 4:3994. 2014
    Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders...
  8. doi MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2
    Li Liang
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, PR China
    Gastroenterology 144:624-635.e4. 2013
    ..We investigated whether microRNAs regulate levels of FMNL2 in colorectal cancer (CRC) cells...
  9. pmc Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer
    Dong Liang Chen
    State Key Laboratory of Oncology in South China
    Carcinogenesis 34:803-11. 2013
    ..Taken together, these results demonstrated that overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in CRC patients...
  10. pmc Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuropsychopharmacology 37:2720-9. 2012
    ..The strongest finding was a locus within an intron of a putative primary transcript for microRNA MIR137. In the current study, we examine the impact of variation at this locus (rs1625579, G/T; where T is the common and ..
  11. doi The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia
    T A Lett
    Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 18:443-50. 2013
    ..the influence of the genome-wide significant schizophrenia risk variant rs1625579 near the microRNA (miRNA)-137 (MIR137) gene on well-established sources of phenotypic variability in schizophrenia: age-at-onset of psychosis and brain ..
  12. pmc MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
    Ariel Bier
    Everard and Mina Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncotarget 4:665-76. 2013
    ..miR-137 inhibits GSC self-renewal and promotes their differentiation by targeting RTVP-1 which downregulates CXCR4. Thus, miR-137 and RTVP-1 are attractive therapeutic targets for the eradication of GSCs and for the treatment of GBM. ..
  13. pmc Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
    Ilaria Guella
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    J Psychiatr Res 47:1215-21. 2013
    ..This study offers additional support for involvement of miR-137 and downstream targets as mechanisms of risk for psychiatric disorders. ..
  14. pmc Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation
    Theo G M van Erp
    Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, University of California Irvine, Irvine, California
    Biol Psychiatry 75:398-405. 2014
    ..miR-137 dysregulation has been implicated in the etiology of schizophrenia, but its functional role remains to be determined...
  15. doi MicroRNA-137 down-regulates KIT and inhibits small cell lung cancer cell proliferation
    Peipei Li
    Department of Respiration, Tangdu Hospital, Fourth Military Medical University, 710038 Xi an, China Department of Respiration, Harrison International Peace Hospital, 053000 Hengshui, China
    Biomed Pharmacother 68:7-12. 2014
    ..Besides, it has also been proved that KIT might be only one of the downstream molecules of miR-137 that related to SCLC MDR. ..
  16. doi MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese
    Fanglin Guan
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an, China Institute of Human Genomics and Forensic Sciences, Xi an, China
    Schizophr Res 152:97-104. 2014
    Recently, evidence has accumulated indicating that the MIR137 gene and the target gene CACNA1C of miR-137 might be two of the most robustly implicated genes in schizophrenia...
  17. doi miR-137 suppresses cell growth in ovarian cancer by targeting AEG-1
    Jinling Guo
    Department of Gynecology, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping road, Nan Gang District, Harbin, 150081, Heilongjiang Province, China
    Biochem Biophys Res Commun 441:357-63. 2013
    ..Taken together, these findings indicate that miR-137 functions as a tumor suppressor by inhibition of AEG-1. These molecules might be targets for prevention or treatment of OC...
  18. ncbi Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer
    M Svoboda
    Oncobios Research Group, CZ 612 00 Brno, Czech Republic
    Int J Oncol 33:541-7. 2008
    ..However, other two micro-RNAs miR125b, miR137 showed a significant increase in median expression levels after starting therapy in most samples...
  19. pmc MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index
    Scott M Langevin
    Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    Carcinogenesis 31:864-70. 2010
    ..The observed associations with gender and BMI help to shed light on potential risk factors for an altered methylation state in SCCHN...
  20. doi MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines
    Lynne T Bemis
    Division of Medical Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Cancer Res 68:1362-8. 2008
    ..Further, we have identified a 15-bp variable nucleotide tandem repeat located just 5' to the pre-miR-137 sequence, which alters the processing and function of miR-137 in melanoma cell lines...
  21. doi Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma
    Xiaoyan Chen
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 52:1193-9. 2011
    ..The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. In this study, they investigated the role of miR-137 in the pathogenesis of uveal melanoma...
  22. doi miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Eur J Cancer 48:3104-11. 2012
    ..In conclusion, our study demonstrates that miR-137 deregulation is common in glioma, and restoration of its function inhibits cell proliferation and invasion, suggesting that miR-137 may act as a tumour suppressor...
  23. doi miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42
    Qingjiang Chen
    Department of Medicine Oncology, The First Affiliated Hospital, Zhengzhou University, 1 East Jianshe Road, 450000, Zhengzhou, People s Republic of China
    Dig Dis Sci 56:2009-16. 2011
    ..Some recent studies show that DNA methylation contributes to down-regulation of microRNA-137 (miR-137) during tumorigenesis. Whether down-regulation of miR-137 also exists in gastric cancer is unknown...
  24. doi Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability
    Marjolein H Willemsen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Med Genet 48:810-8. 2011
    ..Recent studies identified miRNAs as important regulators of learning and memory in model organisms. So far, no mutations in specific miRNA genes have been associated with impaired cognitive functions...
  25. pmc MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease
    Hirosha Geekiyanage
    Genetics Program, Michigan State University, East Lansing, Michigan 48824, USA
    J Neurosci 31:14820-30. 2011
    ..Finally, these results suggest SPT and the respective miRNAs may be potential therapeutic targets for sporadic AD...
  26. pmc MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines
    Yu Deng
    Laboratory of Signal Transduction and Molecular Targeted Therapy, State Key Laboratory of Biotherapy Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Int J Biol Sci 7:133-7. 2011
    ....
  27. pmc MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck
    Scott M Langevin
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer 117:1454-62. 2011
    ..However, the aberrant miR-137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor-specific molecular defect that may contribute to disease progression...
  28. ncbi [Novel miRNA genes hypermethylated in breast cancer]
    V I Loginov
    Institute of General Pathology and Pathophysiology, Moscow, 125315 Russia
    Mol Biol (Mosk) 50:797-802. 2016
    ..These results enable the involvement of three miRNAs (miR-132, miR-137, miR-1258) and the methylation of the genes that encode them in the pathogenesis of breast cancer to be suggested...
  29. pmc Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression
    Amber R Smith
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    Oncotarget 6:12558-73. 2015
    ..Our results demonstrate that miR-137 acts as a tumor-suppressive miRNA in colorectal cancers and negatively regulates oncogenic MSI1. ..
  30. doi miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma
    Yijun Yang
    Division of Molecular and Cellular Biology, Toronto General Research Institute, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 21:2399-411. 2015
    ..Deregulation of miRNA has been implicated in the pathogenesis of multiple myeloma. We identified miR-137 and miR-197, mapped to the chromosome 1p (12)-(21) deletion region, and examined their antimyeloma activity as tumor suppressors...
  31. pmc No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
    Helena Cousijn
    Department of Psychiatry, University of Oxford, Oxford, UK
    Schizophr Res 159:329-32. 2014
    Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown...
  32. pmc MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3
    Youcheng Xiu
    School of Life Science and Biotechnology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    PLoS ONE 9:e109734. 2014
    ..These findings indicate that miR-137 could be a potential oncogene in bladder cancer. ..
  33. doi MIR137 Regulates Starvation-Induced Autophagy by Targeting ATG7
    Yuecheng Zeng
    Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Mol Neurosci 56:815-21. 2015
    ..Human microR-137 (MIR137) is involved in neuronal maturation and neurogenesis, while little is known about its role in cancer...
  34. pmc Polymorphisms in microRNA target sites of forkhead box O genes are associated with hepatocellular carcinoma
    Chao Tan
    Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
    PLoS ONE 10:e0119210. 2015
    ..Further knowledge obtained from this study may provide important evidence for the prevention and targeted therapy of HCC. ..
  35. pmc Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137
    Alix Warburton
    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK
    Schizophr Bull 41:698-707. 2015
    b>MIR137 has been identified as a candidate gene for schizophrenia from genome-wide association studies via association with an intronic single nucleotide polymorphism (SNP), rs1625579...
  36. doi MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo
    Liyu Zhang
    Department of Obstetrics and Gynecology, The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P R China
    Mol Med Rep 12:3107-14. 2015
    ..Notably, the enforced expression of miR-137 suppressed tumor growth in the nude mice models. These findings suggested that miR-137 may act as a tumor suppressor and be used as a potential therapeutic agent for the treatment of EOC...
  37. doi Experimental validation of candidate schizophrenia gene CALN1 as a target for microRNA-137
    Shihui Xia
    Children s Hospital and Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China
    Neurosci Lett 602:110-4. 2015
    b>MIR137, which encodes microRNA-137 (miR-137), and several of its target genes exhibit genome-wide significant associations with schizophrenia...
  38. doi miR-137 inhibits proliferation of melanoma cells by targeting PAK2
    Shuai Hao
    Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China
    Exp Dermatol 24:947-52. 2015
    ..Furthermore, overexpression of PAK2 restored miR-137-mediated suppression of cell proliferation. These findings indicate that miR-137 could inhibit proliferation through targeting PAK2 in melanoma cells. ..
  39. doi miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1
    Yong Han
    Department of Breast and Thyroid Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, People s Republic of China
    Hum Cell 29:30-6. 2016
    ....
  40. doi miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1
    Danni Deng
    Modern Medical Research Center, Third Affiliated Hospital of Soochow University, 185 Juqian Road, Changzhou, Jiangsu, China
    Tumour Biol 37:3331-40. 2016
    ..Taken together, our results indicate that miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1. These findings suggest that miR-137 may serve as a novel therapeutic target in astrocytoma treatment. ..
  41. pmc MicroRNA-137 inhibits cell migration and invasion by targeting bone morphogenetic protein-7 (BMP7) in non-small cell lung cancer cells
    Yan rong Yang
    Department of Respiration, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University Weihui 453100, China
    Int J Clin Exp Pathol 8:10847-53. 2015
    ..Taken together, our findings suggested that miR-137/BMP7 axis could contribute to the progression of NSCLC, suggesting miR-137 as a potential therapeutic target for the treatment of NSCLC. ..
  42. doi MicroRNAs regulate KDM5 histone demethylases in breast cancer cells
    Hélène Denis
    Laboratory of Cancer Epigenetics, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Biosyst 12:404-13. 2016
    ..Altogether, our findings suggest that miRNAs may regulate KDM5 histone demethylase levels in breast cancer and thereby control breast cancer cell proliferation and migration. ..
  43. doi microRNA-137 is downregulated in thyroid cancer and inhibits proliferation and invasion by targeting EGFR
    Yingwei Luo
    Department of Vascular and Thyroid Surgery, The First Affiliated Hospital of China Medical University, No 155 N Nanjing St, Shenyang, 110001, China
    Tumour Biol 37:7749-55. 2016
    ..In conclusion, the present study showed that miR-137 downregulation is associated with malignant progression of thyroid cancer. miR-137 inhibits growth and invasion by targeting EGFR in thyroid cancer cells. ..
  44. pmc Regulation of Transient Site-specific Copy Gain by MicroRNA
    Joshua C Black
    From the Massachusetts General Hospital Cancer Center and Departments of Medicine and
    J Biol Chem 291:4862-71. 2016
    ..Consistent with increased CKS1B expression, miRNA inhibition reduced breast cancer cell sensitivity to cisplatin. Our data identify these miRNAs as regulators of TSSG and copy gains of a drug resistance gene. ..
  45. pmc Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia
    C Wright
    The MIND Research Network, Albuquerque, NM, USA
    Transl Psychiatry 6:e724. 2016
    ..Given that the genes evaluated here are involved in protein kinase A signaling, dysregulation of this pathway through alterations in miR-137 biogenesis may underlie the gray matter loss seen in the disease. ..
  46. doi The SNP rs1625579 in miR-137 gene and risk of schizophrenia in Chinese population: A meta-analysis
    Ping Zhang
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    Compr Psychiatry 67:26-32. 2016
    ..However, subsequent genetic association studies in Chinese population yielded inconsistent results...
  47. doi Down-Regulation of MicroRNA-137 Improves High Glucose-Induced Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells by Up-Regulation of AMPKα1
    Jie Li
    Department of Anesthesiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
    Cell Physiol Biochem 39:847-59. 2016
    ..To investigate the effects of miR-137 on high glucose (HG)-induced vascular injury, and to establish the mechanism underlying these effects...
  48. doi The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals
    Emma J Rose
    Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, 8, Ireland Trinity College Institute of Neuroscience, Trinity College, Dublin, 2, Ireland
    Am J Med Genet B Neuropsychiatr Genet 165:467-71. 2014
    ..However, it remains to be determined whether or not alternative measures of brain structure are related to these functions of miR-137...
  49. doi MiR-137 regulates epithelial-mesenchymal transition in gastrointestinal stromal tumor
    Sheng Liu
    Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China
    Tumour Biol 35:9131-8. 2014
    ..Therefore, miR-137 may function as anti-migration and anti-metastasis in GIST and our study provides a potential approach for developing miR-137-based therapeutic strategy for GIST...
  50. doi MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets
    M Strazisar
    1 Applied Molecular Genomics Unit, Department of Molecular Genetics, VIB, Antwerp, Belgium 2 University of Antwerp, Antwerp, Belgium
    Mol Psychiatry 20:472-81. 2015
    ..in a northern Swedish patient/control population, resulted in the discovery of two functional variants in the MIR137 gene...
  51. pmc MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia
    Astrid Vallès
    Department of Neurocognition, Faculty of Psychology and Neurosciences, Maastricht University, Maastricht, the Netherlands Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behavior, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Psychiatry Neurosci 39:312-20. 2014
    ..Therefore, a molecular network of interacting miR-137 targets may provide insights into the biological processes underlying schizophrenia...
  52. doi miR-137 controls proliferation and differentiation of human adipose tissue stromal cells
    Keun Koo Shin
    Department of Physiology, School of Medicine, Pusan National University, Pusan, Korea
    Cell Physiol Biochem 33:758-68. 2014
    ..Demonstrating the molecular mechanisms of human adipose tissue-derived mesenchymal stem cells (hADSCs) differentiation and proliferation could develop hADSCs-based cell therapy...
  53. pmc Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
    Saleh Tamim
    Children s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 9:e85591. 2014
    ..We suggest that the concomitant increase of these four miRNAs in neuronal stem cells or their repression in tumor cells could produce a robust regulatory effect with major consequences to neuronal differentiation and tumorigenesis...
  54. pmc Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs
    Emilia Kozlowska
    Department of Molecular Biomedicine, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14 Str, 61 704 Poznan, Poland
    Int J Mol Sci 14:16999-7016. 2013
    ..Hence, we demonstrated that certain 5'-end variants of miRNAs might be functional for the regulation of the same targets as canonical miRNAs...
  55. doi miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway
    Yan Cheng
    Department of Digestive Diseases, The Second Affiliated Hospital, Medical School of Xi an Jiaotong University, Xi an, Shaanxi 710004, PR China
    FEBS Lett 588:3274-81. 2014
    ..Moreover, restored Cox-2 expression partially abolished the tumor suppressive effects of miR-137 in GC cells, suggesting miR-137 may suppress GC carcinogenesis by targeting Cox-2. ..
  56. doi miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1
    Xiaolan Zhu
    The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
    Acta Biochim Biophys Sin (Shanghai) 45:80-6. 2013
    ..In conclusion, our results demonstrated that miR-137 was involved in MDR in cancer through modulation of P-gp by targeting YB-1, suggesting that miR-137 might be a potential target for preventing and reversing MDR in tumor cells...
  57. doi Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus
    K Danielsson
    Departments of Odontology Medical Biosciences, Umea University, Umea, Sweden
    J Oral Pathol Med 41:90-5. 2012
    ..The aim of this study was to investigate the expression of miR-21, miR-125b, and miR-203 and to compare RNA levels of their potential targets, the tumor suppressor p53 and its relative p63, both known to be deregulated in OLP...
  58. doi Characterization of the uterine leiomyoma microRNAome by deep sequencing
    Boryana Georgieva
    Department of Plant Physiology and Molecular Biology, University of Plovdiv, 24 TsarAssen St, 4000 Plovdiv, Bulgaria
    Genomics 99:275-81. 2012
    ..The microRNA transcriptomes obtained in this study deliver insights and further expand our understanding the role of small RNAs in uterine leiomyoma development...
  59. pmc Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
    Yantao Du
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Division of Cancer Etiology, Peking University Cancer Hospital and Institute, Fu Cheng Lu, NO, 52 Haidian District, Beijing 100142, China
    BMC Cancer 12:249. 2012
    ..The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR CpG islands and its relationship with miRNA expression...
  60. doi Olea europaea leaf extract alters microRNA expression in human glioblastoma cells
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Cancer Res Clin Oncol 138:1831-44. 2012
    ..The present study aimed to evaluate whether Olea europaea leaf extract (OLE) has an anticancer effect and modulates miRNA expression in GBM...
  61. doi miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect
    Yan Sun
    Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China
    Oncol Rep 28:1346-52. 2012
    ..These results demonstrate that miRNAs (miR-124, miR-137 and miR-340) impair colorectal cancer growth by counteracting the Warburg effect due to regulating alternative splicing of the PKM gene...
  62. doi MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma
    Jun Dang
    Department of Periodontics and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, China
    J Oral Pathol Med 42:315-21. 2013
    ..This raises the possibility to use miR-137 methylation as a biomarker for malignant prediction in patients with OLP...
  63. doi miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
    Xiaolan Zhu
    The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212000, China
    FEBS Lett 587:73-81. 2013
    ..Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137...
  64. doi Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support
    Sjoukje I Lok
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Heart Fail 6:853-61. 2013
    ..In the present study, proteomics identified significant changes in α-1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail...
  65. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...

Research Grants1

  1. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..