MIR126

Summary

Gene Symbol: MIR126
Description: microRNA 126
Alias: MIRN126, miRNA126
Species: human

Top Publications

  1. pmc miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
    Yun Zhang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Cell Biol 15:284-94. 2013
  2. doi MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Tokyo, Japan
    Mol Cancer Res 10:3-10. 2012
  3. doi A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    Kim J Png
    Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 481:190-4. 2011
  4. doi miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A
    Xiaolan Zhu
    The Affiliated People s Hospital, Jiangsu University, Zhenjiang 212001, China
    Acta Biochim Biophys Sin (Shanghai) 44:519-26. 2012
  5. doi Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1
    S Meng
    Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Mol Cell Cardiol 53:64-72. 2012
  6. pmc Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction
    Guangwen Long
    Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Biol Sci 8:811-8. 2012
  7. doi The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β
    Roberto Sessa
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Biochim Biophys Acta 1823:1925-35. 2012
  8. pmc IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal
    Chongxiu Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Circ Res 111:1054-64. 2012
  9. pmc MicroRNA-126 inhibits tumor cell growth and its expression level correlates with poor survival in non-small cell lung cancer patients
    Jiyun Yang
    Center for Human Molecular Biology and Genetics, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS ONE 7:e42978. 2012
  10. pmc let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer
    Edin Jusufovic
    Polyclinic for Pulmonary Diseases, Medical Center Tuzla, Tuzla, Bosnia and Herzegovina
    PLoS ONE 7:e45577. 2012

Scientific Experts

Detail Information

Publications80

  1. pmc miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
    Yun Zhang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Cell Biol 15:284-94. 2013
    ....
  2. doi MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Tokyo, Japan
    Mol Cancer Res 10:3-10. 2012
    ..We showed for the first time that the miR-126/ADAM9 axis plays essential role in the inhibition of invasive growth of pancreatic cancer cells...
  3. doi A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    Kim J Png
    Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 481:190-4. 2011
    ..Our work further reveals endothelial recruitment and endothelial interactions in the tumour microenvironment to be critical features of metastatic breast cancer...
  4. doi miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A
    Xiaolan Zhu
    The Affiliated People s Hospital, Jiangsu University, Zhenjiang 212001, China
    Acta Biochim Biophys Sin (Shanghai) 44:519-26. 2012
    ....
  5. doi Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1
    S Meng
    Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Mol Cell Cardiol 53:64-72. 2012
    ..This study provides the first evidence that miR-126 is downregulated in EPCs from diabetic patients, and impairs EPCs-mediated function via its target, Spred-1, and through Ras/ERK/VEGF and PI3K/Akt/eNOS signal pathway...
  6. pmc Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction
    Guangwen Long
    Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Biol Sci 8:811-8. 2012
    ..A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Our results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI...
  7. doi The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β
    Roberto Sessa
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Biochim Biophys Acta 1823:1925-35. 2012
    ..Our findings suggest that miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation...
  8. pmc IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal
    Chongxiu Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Circ Res 111:1054-64. 2012
    ..Diets high in polyunsaturated fatty acids (PUFAs) may provide athero-protection by ameliorating this effect...
  9. pmc MicroRNA-126 inhibits tumor cell growth and its expression level correlates with poor survival in non-small cell lung cancer patients
    Jiyun Yang
    Center for Human Molecular Biology and Genetics, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS ONE 7:e42978. 2012
    ..It is controversial whether microRNA-126 is a tumor suppressive or oncogenic miRNA. More experiments are needed to determine whether microRNA-126 is associated with non-small cell lung cancer risk and prognosis...
  10. pmc let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer
    Edin Jusufovic
    Polyclinic for Pulmonary Diseases, Medical Center Tuzla, Tuzla, Bosnia and Herzegovina
    PLoS ONE 7:e45577. 2012
    ..Moreover, the regulation of let-7b and miR-126 expression could have therapeutic potential because it could reduce tumor angiogenesis and therefore suppress tumor growth in lung cancer patients...
  11. doi Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity
    Philipp Jakob
    Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland
    Circulation 126:2962-75. 2012
    ....
  12. doi AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics
    Pavani Mocharla
    Cardiovascular Centre, University Hospital Zurich and Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland
    Blood 121:226-36. 2013
    ..Moreover, an alteration of angiomiR-126 expression in CD34(+) PBMCs in diabetes provides a novel pathway causing impaired proangiogenic effects...
  13. pmc Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IκBα
    Xiao Feng
    Department of Gastroenterology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People s Republic of China
    PLoS ONE 7:e52782. 2012
    ..Altered expression of miRNAs has recently demonstrated association with human ulcerative colitis (UC). In this study, we attempted to elucidate the roles of miR-126 in the pathogenesis of UC...
  14. doi Decreased expression of miR-126 correlates with metastatic recurrence of hepatocellular carcinoma
    Hongyuan Chen
    Department of General Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China
    Clin Exp Metastasis 30:651-8. 2013
    ..Our study revealed that down-regulation of miR-126 plays an important role in HCC metastasis, and suggest a potential application of miR-126 in prognosis prediction and HCC treatment...
  15. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
    ..These data suggest that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation...
  16. pmc Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress
    Jing Zhou
    Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Circ Res 113:40-51. 2013
    ..Endothelial microRNA-126 (miR-126) modulates vascular development and angiogenesis. However, its role in the regulation of smooth muscle cell (SMC) function is unknown...
  17. doi MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway
    Nan Li
    Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Tongzhipo Road 138, Changsha, Hunan, People s Republic of China
    Mol Cell Biochem 380:107-19. 2013
    ..These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies...
  18. doi Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer
    Yu Zhang
    Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nangfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P R China
    Oncol Rep 30:1976-84. 2013
    ..miR-126 may be a potential target for the therapeutic strategy against CRC...
  19. doi Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles
    Felix Jansen
    Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich Wilhelms University, Bonn, Germany F J, M H, A C, T S, S P, G N, N W Feinberg Cardiovascular Research Institute, Northwestern University School of Medicine, Chicago, IL X Y Institute of Physiology, University Hospital Bonn, Rheinische Friedrich Wilhelms University, Bonn, Germany D W, S V, B K F and Institute of Innate Immunity, Rheinische Friedrich Wilhelms University, Bonn, Germany B S F
    Circulation 128:2026-38. 2013
    ..The underlying mechanisms of endothelial cell repair are largely unknown. We sought to investigate whether endothelial microparticles (EMPs), released from apoptotic endothelial cells (ECs), influence EC repair...
  20. ncbi miR-126 Suppresses the proliferation of cervical cancer cells and alters cell sensitivity to the chemotherapeutic drug bleomycin
    Qing Yu
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China E mail
    Asian Pac J Cancer Prev 14:6569-72. 2014
    ..Upregulation of miR-126 inhibited cervical cancer cell proliferation and enhanced the sensitivity to BLM. Thus, miR-126 may represent a novel approach to cervical cancer treatment. ..
  21. pmc miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2
    Chenglin Yang
    Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China
    Int J Mol Sci 15:423-37. 2013
    ..Taken together, our data indicate that miR-126 functions as a tumor suppressor in OS, which exerts its activity by suppressing the expression of Sox2. ..
  22. pmc Combination of expression levels of miR-21 and miR-126 is associated with cancer-specific survival in clear-cell renal cell carcinoma
    Daniel Vergho
    Department of Urology and Paediatric Urology, Julius Maximilians University Medical Centre of Würzburg, Wurzburg, Germany
    BMC Cancer 14:25. 2014
    ..The expression of miR-21 and miR-126 was analysed in a large cohort of RCC patients; a combined risk score (CRS)-model was constructed based on expression levels of both miRNAs...
  23. pmc Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals
    Tao Zhang
    Department of Laboratory Medicine, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, China
    Biomed Res Int 2013:761617. 2013
    ....
  24. doi Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer
    Yaling Liu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
    Genes Chromosomes Cancer 53:358-65. 2014
    ..Multivariate analysis indicated that miR-126 was an independent prognostic factor for overall survival, suggesting its clinical significance as a prognostic predictor in CRC patients...
  25. pmc MicroRNA-126 inhibits invasion in bladder cancer via regulation of ADAM9
    A Y Jia
    Department of Pathology and Cell Biology, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Br J Cancer 110:2945-54. 2014
    ..Despite the association of several miRNAs with bladder cancer, little is known about the miRNAs that contribute to bladder cancer progression from non-muscle invasive (NMI) to muscle-invasive (MI) disease...
  26. doi Mir-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2 and Crk, and the tumor suppressor PLK2
    Li Ying Liu
    The Center Laboratory for Biomedical Research, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710004, P R China
    Int J Oncol 45:1257-65. 2014
    ..Our study indicates that miR-126 is a tumor suppressor, which in the future may become a therapeutic target for gastric cancer...
  27. doi Insulin receptor substrate-1 and Golgi phosphoprotein 3 are downstream targets of miR‑126 in esophageal squamous cell carcinoma
    Haomiao Li
    Department of Thoracic Surgery, the Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P R China
    Oncol Rep 32:1225-33. 2014
    ..miR-126 suppressed the proliferation, migration and invasion of ESCC cells, and acted as a tumor suppressor in the carcinogenesis of ESCC. IRS-1 and GOLPH3 are downstream targets of miR-126 at the post-transcriptional level in ESCC. ..
  28. doi miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7
    Yanqin Sun
    Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China
    Biochem Biophys Res Commun 391:1483-9. 2010
    ..As a result, our study demonstrates that miR-126 can inhibit proliferation of non-small cell lung cancer cells through one of its targets, EGFL7...
  29. pmc Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126
    Ratanakanit Harnprasopwat
    Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 399:117-22. 2010
    ..Moreover, its frequency is different among races. Thus, our study emphasizes the importance of identifying new miRNA SNP and its contribution to miRNA biogenesis which is possible link to human genetic disease...
  30. doi Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes
    Anna Zampetaki
    King s British Heart Foundation Centre, King s College London, United Kingdom
    Circ Res 107:810-7. 2010
    ..MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may contribute to common disease complications...
  31. doi MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines
    M Crawford
    The Ohio State University Medical Center, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, DHLRI 473 West 12th Avenue Room 201, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 373:607-12. 2008
    ..Crk is a predicted putative target gene for miR-126. Over-expression of miR126 in a lung cancer cell line resulted in a decrease in Crk protein without any alteration in the associated mRNA...
  32. pmc Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells
    Tamia A Harris
    Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arterioscler Thromb Vasc Biol 30:1990-7. 2010
    ..MicroRNA-126 (miR-126) is highly expressed in endothelial cells, and it regulates angiogenesis and vascular inflammation. Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression...
  33. doi Down-regulation of miR-126 expression in colorectal cancer and its clinical significance
    Xiang Min Li
    Emergency Department of Xiangya Hospital, Central South University, 410008, Changsha, China
    Med Oncol 28:1054-7. 2011
    ....
  34. pmc The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
    Chunguang Guo
    Department of Medicine and Ireland Cancer Center, Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Genes Chromosomes Cancer 47:939-46. 2008
    ..Taken together, we propose that miR-126 regulates PI3K signaling partly by targeting p85beta, and that the loss of miR-126 may provide a selective growth advantage during colon carcinogenesis...
  35. pmc MicroRNA-126 regulates HOXA9 by binding to the homeobox
    Wei Fang Shen
    Department of Medicine, University of California, San Francisco, California, USA
    Mol Cell Biol 28:4609-19. 2008
    ..In support of this hypothesis, expression of miR-126 alone in MLL-ENL-immortalized bone marrow cells decreased endogenous HOXA9 protein, while inhibition of endogenous miR-126 increased expression of HOXA9 in F9 cells...
  36. doi Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk
    Rongxi Yang
    Division Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
    Breast Cancer Res Treat 127:549-54. 2011
    ..None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk...
  37. doi The cell growth suppressor, mir-126, targets IRS-1
    Jin Zhang
    Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical College, Fudan University, Shanghai, China
    Biochem Biophys Res Commun 377:136-40. 2008
    ..In conclusion, we developed a simple method for high-throughput screening of miRNAs and found that mir-126, a cell growth suppressor, targets IRS-1...
  38. pmc Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells
    Xinqiang Huang
    Howard Hughes Medical Institute, Los Angeles, CA, USA
    Blood 117:2157-65. 2011
    ..Our results define an important function of miRs-126/126* in negative regulation of erythropoiesis, providing the first evidence for a role of miR in hematopoietic differentiation of hESCs...
  39. doi Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2
    Ni Zhu
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Mol Cell Biochem 351:157-64. 2011
    ..In addition, miR-126 could target both VEGFA and PIK3R2, and its expression was decreased in human breast cancer, implying that miR-126 may play a role in tumor genesis and growth by regulating the VEGF/PI3K/AKT signaling pathway...
  40. doi Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells
    Yoshimasa Saito
    Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9181, USA
    Biochem Biophys Res Commun 379:726-31. 2009
    ..Thus, epigenetic therapy not only directly activates miRNAs from their own promoters, but also activates intronic miRNAs together with their host genes. This reveals an additional mechanism and anticancer effect of epigenetic therapy...
  41. doi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
    ..miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients...
  42. doi miR-126 functions as a tumour suppressor in human gastric cancer
    Runhua Feng
    Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 20025, People s Republic of China
    Cancer Lett 298:50-63. 2010
    ..Mechanistically, we identified the adaptor protein Crk as a target of miR-126. Taken together, our results suggest that miR-126 may function as a tumour suppressor in gastric cancer, with Crk as a direct target...
  43. doi MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo
    Bo Liu
    Cardiovascular Department, Changhai Hospital, Shanghai, China
    Lung Cancer 66:169-75. 2009
    ..8035+/-0.1521 to 0.6235+/-0.0757g, with the inhibitive rate being 22.4%. All these results revealed that miR-126 may have a tumor suppressor function in lung cancer cells and could be a promising treatment in anticancer therapy...
  44. pmc MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis
    Takeshi Otsubo
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e16617. 2011
    ..Here, we assessed whether microRNAs (miRNAs) regulate SOX2 expression in gastric cancers. Furthermore, we attempted to find downstream target genes of SOX2 contributing to gastric carcinogenesis...
  45. doi miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5
    Edit Miko
    Dept of Biochemistry and Molecular Biology, Clinical Genomics Center, University of Debrecen Medical and Health Science Center, Hungary
    FEBS Lett 585:1191-6. 2011
    ..Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126...
  46. doi miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression
    Irene K Oglesby
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Ireland
    J Immunol 184:1702-9. 2010
    ..To our knowledge, this study is the first to report of a role for TOM1 in the TLR2/4 signaling pathways and the first to describe microRNA involvement in CF...
  47. pmc Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways
    Yu Zhou
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China Department of Gastroenterology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong Province, China
    PLoS ONE 8:e81203. 2013
    ..In this study, we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 (IRS-1) and its possible signaling pathway by miR-126...
  48. doi Exercise training improves high-density lipoprotein-mediated transcription of proangiogenic microRNA in endothelial cells
    Saskia Riedel
    Department of Cardiology, University Leipzig Heart Center Leipzig, Leipzig, Germany
    Eur J Prev Cardiol 22:899-903. 2015
    ..The aim of the present study was to evaluate if HDL-induced miR expression is altered in CHF and if exercise training has an impact...
  49. doi MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)
    Xin Sun
    Department of Otorhinolarynology, Shengjing Hospital, China Medical University, Shenyang 110004, P R China
    Int J Oncol 44:1678-84. 2014
    ..In addition, Camsap1 expression induced microtubule formation and aggregation. This mechanism possibly explains why loss of miR-126 is frequently associated with tumor metastasis. ..
  50. doi MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage
    Joanna E Kontaraki
    Molecular Cardiology Laboratory, School of Medicine, University of Crete, Greece Electronic address
    J Am Soc Hypertens 8:368-75. 2014
    ..Thus, they may possibly represent potential biomarkers and candidate therapeutic targets in essential hypertension...
  51. ncbi Down-regulation of MicroRNA-126 in Glioblastoma and its Correlation with Patient Prognosis: A Pilot Study
    In Bo Han
    Department of Neurosurgery, CHA University, Bundang Cha Medical Center, Gyeonggido, Republic of Korea
    Anticancer Res 36:6691-6697. 2016
    ..Future clinical studies with larger sample sizes should be performed to validate this observation...
  52. pmc Osteoblast-derived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126
    Huai Ching Tai
    Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    Oncotarget 5:7589-98. 2014
    ..Thus, WISP-1 may be a new molecular therapeutic target in PCa bone metastasis. ..
  53. doi Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer
    Tomomi Fujii
    Department of Pathology, Nara Medical University School of Medicine, Nara, Japan
    Biochem Biophys Res Commun 456:183-9. 2015
    ..These miRNAs promote cell proliferation by suppressing SOX2, NANOG, and Oct4. The regulation of these factors by miR-126 and miR-149 is essential for syndecan-1-mediated development of androgen-refractory prostate cancer...
  54. doi A genetic variant regulating miR-126 is associated with sight threatening diabetic retinopathy
    Annie K McAuley
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Vic, Australia
    Diab Vasc Dis Res 12:133-8. 2015
    ....
  55. pmc Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients
    Yoshihiko Shibayama
    Education Research Center for Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060 0812, Japan
    Oncol Rep 33:2176-82. 2015
    ..The results of the present study demonstrated that higher expression levels of miR-126-5p/3p in patients with AML resulted in a poorer prognosis. Furthermore, miR-126-5p elevated the phosphorylation of Akt...
  56. doi MicroRNA-126 inhibits cell proliferation in gastric cancer by targeting LAT-1
    Junqing Wang
    Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197, Rui Jin Er Road, Shanghai 20025, People s Republic of China Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197, Rui Jin Er Road, Shanghai 20025, People s Republic of China Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 197, Rui Jin Er Road, Shanghai 20025, People s Republic of China Electronic address
    Biomed Pharmacother 72:66-73. 2015
    ..This might provide us likely potential biomarkers and targets for GC prevention, diagnosis and therapeutic treatment. ..
  57. pmc Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis
    Jie Bu
    Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China
    Dis Markers 2015:739469. 2015
    ..Increasing studies found that miR-126 expression may be associated with the prognosis of cancers. Here, we performed a meta-analysis to assess the prognostic role of miR-126 in different cancers...
  58. pmc Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS
    Jingying Han
    Department of Orthodontics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China mainland
    Med Sci Monit 22:522-9. 2016
    ....
  59. doi Expression of miR-155 and miR-126 in situ in cutaneous T-cell lymphoma
    Katharina L Kopp
    Department of International Health, Immunology and Microbiology UoC, Copenhagen, Denmark
    APMIS 121:1020-4. 2013
    ..Taken together, our findings suggest that both malignant and non-malignant T cells express miR-155 in situ in CTCL. Moreover, they indicate heterogeneity in miR-155 expression among malignant T cells. ..
  60. pmc MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors
    Kazuki Okuyama
    Division of Hematological Malignancy, Regenerative Medical Science, Tokai University School of Medicine, Kanagawa 259 1193, Japan
    Proc Natl Acad Sci U S A 110:13410-5. 2013
    ..These experiments show that miR-126 regulates myeloid vs. B-cell fate through an alternative machinery, establishing the critical role of miRNAs in the lineage specification of multipotent mammalian cells. ..
  61. doi MicroRNA-126 regulates EPCs function: implications for a role of miR-126 in preeclampsia
    Ting Yan
    Department of Gynecology and Obstetrics, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China
    J Cell Biochem 114:2148-59. 2013
    ..These findings suggest that miR-126 is essential for angiogenic properties of EPCs in vitro and placental vasculogenesis in vivo, providing basis for an alternative therapeutic approach in patients with preeclampsia...
  62. pmc MicroRNA-126 and epidermal growth factor-like domain 7-an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial
    T F Hansen
    Department of Oncology, Vejle Hospital, Lillebaelt Hospital, Denmark
    Br J Cancer 109:1243-51. 2013
    ....
  63. pmc MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway
    Andong Qin
    Department of Immunology, Zunyi Medical College, Guizhou, 563000, China
    J Cell Mol Med 17:252-64. 2013
    ....
  64. pmc Attenuation of miR-126 activity expands HSC in vivo without exhaustion
    Eric R Lechman
    Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada
    Cell Stem Cell 11:799-811. 2012
    ..These data establish that miR-126 sets a threshold for HSC activation and thus governs HSC pool size, demonstrating the importance of miRNA in the control of HSC function...
  65. doi MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia
    Coen van Solingen
    Department of Nephrology, LUMC, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Cardiovasc Res 92:449-55. 2011
    ..Based on the seed sequence, miR-126 can also be predicted to regulate vasculogenesis by modulating the endothelial expression of stromal cell-derived factor-1 (SDF-1)...
  66. doi Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression
    Shuang Liu
    Department of Gynecology and Obstetrics, Shengjing Hospital, China Medical University, 36 Sanhao Street, Shenyang 110004, China
    Arch Gynecol Obstet 285:1065-72. 2012
    ..To evaluate the relationship between miR-126 and Crk and discuss the role of miR-126 in the development and progression of endometriosis (EMs)...
  67. ncbi [Differential expression of hsa-miR-126 and hsa-miR-518b in esophageal squamous carcinoma]
    Hui Cai
    Department of Oncology Surgery, Xi an Jiaotong University College of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:23-7. 2011
    ..To identify the differentially expressed microRNAs (miRNAs) between esophageal squamous carcinoma (ESC) and adjacent non-tumorous tissue (NT)...
  68. pmc Adipose tissue microRNAs as regulators of CCL2 production in human obesity
    Erik Arner
    RIKEN Omics Science Center, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan
    Diabetes 61:1986-93. 2012
    ..Taken together, our data suggest that miRNAs may be important regulators of adipose inflammation through their effects on CCL2 release from human adipocytes and macrophages...
  69. pmc Increased expression of vascular cell adhesion molecule 1 in muscle biopsy samples from juvenile dermatomyositis patients with short duration of untreated disease is regulated by miR-126
    Erin Kim
    Children s Hospital of Chicago Research Center, Chicago, Illinois, USA
    Arthritis Rheum 64:3809-17. 2012
    ....
  70. pmc MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways
    Svenja Daschkey
    Heinrich Heine University Dusseldorf, Medical Faculty, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Dusseldorf, Germany
    PLoS ONE 8:e56334. 2013
    ..First studies in children investigate single selected miRNAs, however, a comprehensive overview of miRNA expression and function in children and young adults is missing so far...
  71. pmc miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma
    Nadia Felli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    PLoS ONE 8:e56824. 2013
    ..In view of this miR-126&126* wide-ranging action, we believe that the replacement of these microRNAs might be considered a promising therapeutic approach...
  72. pmc Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma
    Megan E McNally
    Division of Surgical Oncology, Ohio State University Medical Center, OH, USA
    HPB (Oxford) 15:260-4. 2013
    ..MicroRNAs (miRNAs) are small non-coding genes which become dysregulated in cancer and may predict survival. The role of miRNAs in outcomes in cholangiocarcinoma (CC) has not been reported...
  73. pmc Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors
    Ranjan Dutta
    Department of Neurosciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Neurol 73:637-45. 2013
    ..How demyelination alters neuronal gene expression is unknown...
  74. doi miR-126 and miR-126*: new players in cancer
    Jeannette Meister
    Molecular Signal Transduction, Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University School of Medicine, Frankfurt am Main, Germany
    ScientificWorldJournal 10:2090-100. 2010
    ....
  75. pmc Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells
    Alla Musiyenko
    Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, Alabama 36688 0002, USA
    J Mol Med (Berl) 86:313-22. 2008
    ..We conclude that intronic miRNAs from tissue-specific transcripts, or their natural absence, make cardinal contributions to cellular gene expression and phenotype. These findings also open the door to tissue-specific miRNA therapy...
  76. pmc Identification of differentially expressed microRNA in parathyroid tumors
    Reza Rahbari
    Endocrine Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, MD, USA
    Ann Surg Oncol 18:1158-65. 2011
    ....
  77. doi Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30615 Hanover, Germany
    Ann Hematol 88:325-32. 2009
    ..No association to thrombocytosis, JAK2(V617F) mutations or cytoreductive treatment (bone marrow cells) were observed...
  78. pmc The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes
    Hyun Su Ryu
    Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea
    PLoS ONE 6:e17343. 2011
    ....
  79. ncbi [miR-126 modulates the expression of epidermal growth factor-like domain 7 in human umbilical vein endothelial cells in vitro]
    Yan qin Sun
    Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:767-70. 2010
    ..To investigate the regulatory effect of miR-126 on epidermal growth factor-like domain 7 (EGFL7) in ECV-304 cells...
  80. pmc Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma
    Lory Santarelli
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
    PLoS ONE 6:e18232. 2011
    ..Since recent data point to abnormal levels of microRNAs (miRNAs) in tumors, we hypothesized that a profile of deregulated miRNAs may be a marker of MPM and that the levels of specific miRNAs may be used for monitoring its progress...