MIF

Summary

Gene Symbol: MIF
Description: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Alias: GIF, GLIF, MMIF, macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, phenylpyruvate tautomerase
Species: human

Top Publications

  1. pmc Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor
    W Y Weiser
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:7522-6. 1989
  2. ncbi The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents
    Jodi B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:24976-82. 2002
  3. ncbi A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
    J A Baugh
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Genes Immun 3:170-6. 2002
  4. ncbi Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
  5. ncbi Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
  6. doi Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas
    Xiao Bing Wang
    Department of Pathology, Guangdong General Hospital, 106, Zhongshan Road II, Guangzhou, China
    J Neurooncol 106:43-51. 2012
  7. ncbi Cloning the human gene for macrophage migration inhibitory factor (MIF)
    V Paralkar
    Section on Molecular Structure and Function, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 19:48-51. 1994
  8. doi Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity
    Kuninobu Wakabayashi
    Division of Rheumatology, Department of Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Mod Rheumatol 22:59-65. 2012
  9. pmc Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
  10. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001

Research Grants

  1. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
  2. CHANGHYON CHRIS YUN; Fiscal Year: 2015
  3. PATRICIA JEAN JOHNSON; Fiscal Year: 2014
  4. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
  5. Thomas Yoonsang Cho; Fiscal Year: 2015
  6. Pedro L Vera; Fiscal Year: 2016
  7. Laura E Nagy; Fiscal Year: 2016
  8. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
  9. Arthur A Vandenbark; Fiscal Year: 2016
  10. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012

Detail Information

Publications274 found, 100 shown here

  1. pmc Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor
    W Y Weiser
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:7522-6. 1989
    A cDNA encoding a human macrophage migration inhibitory factor (MIF) was isolated, through functional expression cloning in COS-1 cells, from a cDNA library prepared from a lectin-stimulated T-cell hybridoma, T-CEMB...
  2. ncbi The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents
    Jodi B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:24976-82. 2002
    b>Macrophage migration inhibitory factor (MIF) is an immunoregulatory protein that is a potential therapeutic target for a number of inflammatory diseases...
  3. ncbi A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
    J A Baugh
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Genes Immun 3:170-6. 2002
    The macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine and regulates the anti-inflammator effects of glucocorticoids...
  4. ncbi Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
    To study the capacity of macrophage migration inhibitory factor (MIF) to regulate proliferation, apoptosis, and p53 in an animal model of rheumatoid arthritis (RA) and in fibroblast-like synoviocytes (FLS) from humans with RA.
  5. ncbi Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
    b>Macrophage migration inhibitory factor (MIF) is a pro-inflammatory mediator with the ability to induce various immunomodulatory responses and override glucocorticoid-driven immunosuppression...
  6. doi Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas
    Xiao Bing Wang
    Department of Pathology, Guangdong General Hospital, 106, Zhongshan Road II, Guangzhou, China
    J Neurooncol 106:43-51. 2012
    b>Macrophage migration inhibitory factor (MIF) plays a critical role in tumorigenesis...
  7. ncbi Cloning the human gene for macrophage migration inhibitory factor (MIF)
    V Paralkar
    Section on Molecular Structure and Function, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 19:48-51. 1994
    b>Macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine. However, recent work strongly suggests a wider role for MIF beyond the immune system...
  8. doi Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity
    Kuninobu Wakabayashi
    Division of Rheumatology, Department of Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Mod Rheumatol 22:59-65. 2012
    b>Macrophage migration inhibitory factor (MIF) is recognized to be an important mediator in several inflammatory disorders, including rheumatoid arthritis (RA) and vasculitis...
  9. pmc Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
    ..b>Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules and ..
  10. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001
    To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA).
  11. ncbi The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability
    Alexander Schmeisser
    Medical Clinic II, Department of Cardiology, University of Technology Dresden, PO Box 95, Fetscherstr 74, 01307 Dresden, Germany
    Atherosclerosis 178:83-94. 2005
    b>Macrophage migration inhibitory factor 1alpha (MIF), a cytokine with immunoregulatory functions has been suggested to be involved in atherosclerotic plaque development...
  12. ncbi Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor
    Beatriz E Rendon
    Molecular Targets Program, J G Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 282:29910-8. 2007
    b>Macrophage migration inhibitory factor (MIF) is expressed and secreted in response to mitogens and integrin-dependent cell adhesion...
  13. ncbi Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy
    F Arcuri
    Institute of Pathological Anatomy and Histology and Institute of General Physiology, University of Siena, Siena 53100, Italy
    Biol Reprod 64:1200-5. 2001
    b>Macrophage migration inhibitory factor (MIF) was discovered as an activated T-lymphocyte-derived protein that inhibits the random migration of macrophages in vitro...
  14. pmc Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis
    H Murakami
    Third Department of Internal Medicine, Ehime University School of Medicine, Japan
    Clin Exp Immunol 128:504-10. 2002
    The level of macrophage migration inhibitory factor (MIF) and the functions of dendritic cells (DC) are up-regulated in the peripheral blood, and the numbers of MIF-expressing cells and mature DC are increased at the colonic mucosa from ..
  15. ncbi Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes
    John N Fain
    Department of Molecular Sciences, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 55:1113-21. 2006
    ..to compare the relative release of interleukin 1 receptor antagonist (IL-1Ra), cathepsin S, macrophage migration inhibitory factor (MIF), nerve growth factor (NGF), and interleukin 18 (IL-18) by adipocytes as compared with the ..
  16. pmc The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors
    Caroline Piette
    Laboratory of Tumor and Developmental Biology, GIGA R, CHU, Liege, Belgium
    J Biol Chem 284:32483-92. 2009
    ..b>Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs...
  17. ncbi Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism
    D Rigante
    Department of Paediatric Sciences, Catholic University of Sacred Heart, Rome, Italy
    Scand J Rheumatol 36:307-10. 2007
    To examine the association of the -173 single-nucleotide G/C polymorphism of the macrophage migration inhibitory factor gene (MIF) and serum macrophage migration inhibitory factor (MIF) concentrations in a group of Italian patients with ..
  18. ncbi Macrophage migration inhibitory factor in the human prostate: identification and immunocytochemical localization
    F Arcuri
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Prostate 39:159-65. 1999
    b>Macrophage migration inhibitory factor (MIF) is a lymphokine originally identified for its capacity to inhibit the random migration of macrophages...
  19. doi Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells
    Bonnie L Barrilleaux
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA
    Tissue Eng Part A 15:2335-46. 2009
    ..This was partly due to a dose-dependent response to macrophage migration inhibitory factor (MIF)...
  20. ncbi Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma
    Stéphanie Cludts
    Laboratory of Anatomy and Cellular Biology, Faculty of Medicine and Pharmacy, University of Mons Hainaut, Mons, Belgium
    Anticancer Res 30:3313-9. 2010
    To examine the presence of macrophage migration inhibitory factor (MIF) quantitatively in relation to neoplastic progression of hypopharyngeal squamous cell carcinoma (HSCC).
  21. doi Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro
    Ling Yuh Shyu
    Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
    Thromb Res 129:43-9. 2012
    b>Macrophage migration inhibitory factor (MIF) is an important cytokine in the modulation of inflammatory and immune responses, but its role in coagulation remains to be elucidated...
  22. ncbi Elevated levels of macrophage migration inhibitory factor in the peripheral blood of women with endometriosis
    Mathieu Morin
    Laboratoire d endocrinologie de la reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec CHUQ, Faculte de Medecine, Universite Laval, 10 rue de l Espinay, Quebec, PQ, Canada G1L 3L5
    Fertil Steril 83:865-72. 2005
    To evaluate the concentrations of macrophage migration inhibitory factor (MIF) in the peripheral blood of normal women and patients with endometriosis.
  23. ncbi Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium
    Raj Wadgaonkar
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Cell Biochem 95:849-58. 2005
    ..922 aa) as bait, identified additional stable MLCK binding partners including the 12 KDa macrophage migration inhibitory factor (MIF)...
  24. doi Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervaenget 6, Odense C, Denmark
    Clin Endocrinol (Oxf) 71:652-8. 2009
    ..sensitizing treatment reduces the inflammatory state, but the effect on serum levels of migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha have not been evaluated ..
  25. ncbi Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Biochemistry 33:14144-55. 1994
    The cytokine macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock...
  26. ncbi Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma
    Eiji Hira
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan
    Cancer 103:588-98. 2005
    b>Macrophage migration inhibitory factor (MIF) is a pivotal cytokine that regulates inflammatory and immune responses...
  27. pmc Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants
    Eloísa Amália Vieira Ferro
    Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Av Pará, 1720, Uberlandia, Minas Gerais, Brasil 38405320
    Am J Pathol 172:50-8. 2008
    Considering the potential role of macrophage migration inhibitory factor (MIF) in the inflammation process in placenta when infected by pathogens, we investigated the production of this cytokine in chorionic villous explants obtained from ..
  28. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
    The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF...
  29. ncbi Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery
    F M H van Dielen
    Department of General Surgery, Nutrition Research Institute Maastricht and University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:4062-8. 2004
    ..However, 2 yr after surgery, the inflammatory mediators reach near normal values.These findings may be an explanation for the reduced comorbidity seen in morbidly obese patients after gastric restrictive surgery...
  30. ncbi Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    John A Baugh
    School of Medicine and Medical Science, The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Biophys Res Commun 347:895-903. 2006
    b>Macrophage migration inhibitory factor (MIF) is a well-described pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression...
  31. ncbi Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
    R Kleemann
    Laboratory of Biochemistry Institute for Interfacial Engineering, University of Stuttgart, Germany
    Nature 408:211-6. 2000
    ..b>Macrophage migration inhibitory factor (MIF) is a cytokine that has a critical role in several inflammatory conditions but that also has ..
  32. ncbi Expression of macrophage migration inhibitory factor in human breast cancer: association with nodal spread
    Hiroko Bando
    Breast Unit, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo 113 0021, Japan
    Jpn J Cancer Res 93:389-96. 2002
    b>Macrophage migration inhibitory factor (MIF) is known to exert pleiotropic functions including inhibition of macrophage migration, anchoring, and counteraction of the anti-inflammatory and immunosuppressive activity of glucocorticoids...
  33. pmc Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme
    Michael Bacher
    Institute of Immunology, Philipps University Marburg, Germany
    Am J Pathol 162:11-7. 2003
    ..b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine released by leukocytes and by a variety of cells outside of the ..
  34. ncbi Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter
    Oliver Flieger
    Institute for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, 70569 Stuttgart, Germany
    FEBS Lett 551:78-86. 2003
    The cytokine macrophage migration inhibitory factor (MIF) is inducibly secreted by immune cells and certain other cell types to critically participate in the regulation of the host immune response...
  35. ncbi Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    Tadamichi Shimizu
    Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 279:13729-37. 2004
    b>Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
  36. ncbi Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
    To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA).
  37. ncbi Macrophage migration inhibitory factor promotes intestinal tumorigenesis
    Jonathan M Wilson
    Molecular Medicine Unit, University of Leeds, Leeds, United Kingdom
    Gastroenterology 129:1485-503. 2005
    The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models...
  38. pmc Macrophage migration inhibitory factor: a central regulator of wound healing
    Matthew J Hardman
    Faculty of Life Sciences, University of Manchester, UK
    Am J Pathol 167:1561-74. 2005
    ..expression within the wounds of mice that were wild type or null for the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in the presence or absence of estrogen...
  39. ncbi Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 7:433-6. 2006
    The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus...
  40. ncbi Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma
    Sou Pan Wu
    Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    Arthritis Rheum 54:3661-9. 2006
    To investigate the potential association between functional polymorphisms in the gene for the innate mediator, macrophage migration inhibitory factor (MIF), and the clinical expression of systemic sclerosis (SSc).
  41. ncbi Increases in serum macrophage migration inhibitory factor in patients with severe sepsis predict early mortality
    Chia C Chuang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Shock 27:503-6. 2007
    This prospective study aimed to delineate the association between the serum levels of macrophage migration inhibitory factor (MIF) and the risks of early mortality in 112 patients who presented with clinically severe sepsis...
  42. ncbi Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:744-7. 2007
    The macrophage inhibitory factor (MIF) is a cytokine that has been implicated in several inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus, glomerulonephritis, and multiple sclerosis...
  43. ncbi Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
    Ayumi Honda
    Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Dermatol Sci 49:63-72. 2008
    ..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
  44. doi Overexpression of macrophage migration inhibitory factor induces angiogenesis in human breast cancer
    Xiangdong Xu
    Department of Center of Breast Disease, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou 510080, China
    Cancer Lett 261:147-57. 2008
    b>Macrophage migration inhibitory factor (MIF) is known to be an important contributor to tumor progression. Overexpression of MIF has been reported in different types of tumors...
  45. doi Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells
    Véronique Veillat
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 91:2148-56. 2009
    To investigate the involvement of the nuclear factor (NF)-kappaB in the interleukin (IL)-1 beta-mediated macrophage migration inhibitory factor (MIF) gene activation.
  46. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    The cytokine, macrophage migration inhibitory factor (MIF), is encoded in a functionally polymorphic locus and subjects with high-expression MIF alleles are at an increased risk of inflammatory disease...
  47. ncbi Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity
    J B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biochemistry 38:7346-54. 1999
    b>Macrophage migration inhibitory factor (MIF) is an important immunoregulatory molecule with a unique ability to suppress the anti-inflammatory effects of glucocorticoids...
  48. ncbi Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
    Sujittra Chaisavaneeyakorn
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia 30341, USA
    J Infect Dis 186:1371-5. 2002
    b>Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids...
  49. ncbi Macrophage migration inhibitory factor (MIF) expression in human glioblastomas correlates with vascular endothelial growth factor (VEGF) expression
    C Munaut
    Laboratoire de Biologie des Tumeurs et du Developpement, Universite de Liege, Belgium
    Neuropathol Appl Neurobiol 28:452-60. 2002
    b>Macrophage migration inhibitory factor (MIF) is a peptide released upon hypothalamo-pituitary stimulation that acts as a potent endogenous antagonist of the glucocorticoid inhibition of acute inflammatory response and subsequent antigen-..
  50. ncbi Macrophage migration inhibitory factor in human pregnancy and labor
    F Ietta
    Department of Physiology, Division of Immunoendocrinology and Reproductive Physiology University of Siena, Siena, Italy
    Am J Reprod Immunol 48:404-9. 2002
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in reproduction. Presently there is no information on the possible involvement of MIF in the onset of labor.
  51. ncbi The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis
    Mai Tuyet Nguyen
    Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart and Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany
    J Immunol 170:3337-47. 2003
    The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis...
  52. ncbi Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis
    Fabrizio De Benedetti
    IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
    Arthritis Rheum 48:1398-407. 2003
    ..the functional and prognostic relevance of the -173 single-nucleotide G-to-C polymorphism of the macrophage migration inhibitory factor (MIF) gene in patients with systemic-onset juvenile idiopathic arthritis (systemic-onset JIA) by ..
  53. ncbi Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester, UK
    Genes Immun 4:487-91. 2003
    The aim of the study was to investigate whether polymorphisms of macrophage migration inhibitory factor (MIF) determine susceptibility to or severity of inflammatory polyarthritis (IP)...
  54. ncbi Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy
    Nobuyuki Hizawa
    First Department of Medicine, Hokkaido University School of Medicine, Kita Ku N 15 W 7, Sapporo, Japan 060 8638
    Am J Respir Crit Care Med 169:1014-8. 2004
    b>Macrophage migration inhibitory factor (MIF) is a pleiotrophic lymphocyte and macrophage cytokine; it is likely to play an important role in innate immunity...
  55. ncbi Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta
    Shin Onodera
    Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Arthritis Rheum 50:1437-47. 2004
    ..This study was undertaken to investigate the IL-8 inductive activity of the macrophage migration inhibitory factor (MIF) in RA synovial fibroblasts...
  56. ncbi Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor
    Leilani L Santos
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    J Rheumatol 31:1038-43. 2004
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine important in animal models of rheumatoid arthritis (RA)...
  57. ncbi Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis
    Rachelle P Donn
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    J Invest Dermatol 123:484-7. 2004
    b>Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis...
  58. ncbi Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:5043-7. 2004
    The objective of the study was to determine whether plasma migration inhibitor factor (MIF) concentration and mononuclear cell (MNC) mRNA are elevated in obesity and whether treatment with metformin reduces plasma MIF concentration...
  59. pmc Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines Veterans Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 5:73. 2005
    b>Macrophage migration inhibitory factor (MIF) is a cytokine associated with prostate cancer, based on histologic evidence and circulating (serum) levels. Recent studies from another laboratory failed to document these results...
  60. ncbi Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1
    Thierry Roger
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 35:3405-13. 2005
    The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) acts as a physiological counter-regulator of the immuno-suppressive effects of glucocorticoids...
  61. pmc Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
    ..05). However, Erk1/2 and Jak2 were not involved. Silencing RNA directed against MIF, and inhibitors of Src, PI3K, NFkappaB, anti-VCAM-1, and anti-ICAM-1 significantly inhibited rhMIF-induced adhesion ..
  62. ncbi Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    Julia Dambacher
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 13:71-82. 2007
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with increased expression in inflammatory bowel disease...
  63. ncbi Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia, and Instituto de Parasitología y Biomedicina Lopez Neyra, CSIC, Grenada, Spain
    Tissue Antigens 70:28-33. 2007
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic...
  64. ncbi A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Hepatogastroenterology 54:784-6. 2007
    b>Macrophage migration inhibitory factor (MIF) is an important cytokine involved in the regulation of the innate immune system in IBD...
  65. ncbi Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
    Thorsten Hagemann
    Queen Mary s Medical School, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Mol Cancer Ther 6:1993-2002. 2007
    In view of our previous findings that tumor cell-derived macrophage migration inhibitory factor (MIF) increased macrophage-mediated ovarian cancer cell invasiveness in vitro, we investigated the wider significance of ovarian cancer cell-..
  66. ncbi Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population
    Bao ying Fei
    Department of Gastroenterology, Zhejiang Provincial People s Hospital, Hangzhou 310014, China
    Cytokine 41:44-7. 2008
    To study whether macrophage migration inhibitory factor (MIF)-173 gene polymorphism correlates with inflammatory bowel disease (IBD) in Chinese Han population.
  67. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
    ..Recent studies have revealed that macrophage migration inhibitory factor (MIF) expression is increased in lung cancer, particularly non-small cell lung carcinomas (NSCLC)...
  68. pmc Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, GermanyAachen, Germany
    Proc Natl Acad Sci U S A 105:16278-83. 2008
    We have recently identified the archaic cytokine macrophage migration inhibitory factor (MIF) as a non-canonical ligand of the CXC chemokine receptors CXCR2 and CXCR4 in inflammatory and atherogenic cell recruitment...
  69. pmc Macrophage migration inhibitory factor promotes colorectal cancer
    Xing Xiang He
    Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China
    Mol Med 15:1-10. 2009
    A growing body of evidence implicates macrophage migration inhibitory factor (MIF) in tumorigenesis and metastasis...
  70. doi Increase of macrophage migration inhibitory factor (MIF) expression in cardiomyocytes during chronic hypoxia
    Zhao Jian
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, 183 Xinqiao Street, Chongqing 400037, PR China
    Clin Chim Acta 405:132-8. 2009
    b>Macrophage migration inhibitory factor (MIF) might play an important role in the myocardium during chronic hypoxia because MIF protects the heart during myocardial ischemia by activating 5'-adenosine monophosphate activated protein kinase ..
  71. pmc MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Infect Dis 200:629-37. 2009
    ..The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA.
  72. doi Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
    Aoi Son
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Antioxid Redox Signal 11:2595-605. 2009
    ..b>Macrophage migration inhibitory factor (MIF) is a 12 kDa cytokine belonging to the TRX family...
  73. pmc Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer
    Eva Verjans
    Department of Biochemistry and Molecular Cell Biology, RWTH Aachen University Hospital, Aachen, Germany
    BMC Cancer 9:230. 2009
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases...
  74. pmc Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation
    Katherine L Meyer-Siegler
    Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL 33744, USA
    Cancer Lett 290:49-57. 2010
    Mounting evidence suggests that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and carcinogenesis as evidenced by the increase in serum MIF found in ..
  75. doi High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase
    Jia Liang Liang
    Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
    Clin Exp Pharmacol Physiol 37:969-73. 2010
    1. It is known that high glucose can induce cardiomyocyte apoptosis and that macrophage migration inhibitory factor (MIF) may be involved in the development of diabetes...
  76. doi Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin II
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Cytokine 53:35-41. 2011
    b>Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque stability. MIF was shown to be highly expressed in advanced atherosclerotic lesions...
  77. pmc Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
    Xi Yong Yu
    Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    PLoS ONE 6:e16239. 2011
    ..The purpose of this study was to examine the expression levels of macrophage migration inhibitory factor (MIF) and G protein-coupled receptor kinase 2 (GRK2) in patients with early diabetic ..
  78. doi Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course
    Mara Anaís Llamas-Covarrubias
    Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col Independencia, 44348 Guadalajara, Jalisco, Mexico
    Rheumatol Int 32:2307-11. 2012
    ..Many cytokines have been found to be associated with RA pathogenesis and among them is macrophage migration inhibitory factor (MIF)...
  79. pmc Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus
    Antoine Sreih
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Arthritis Rheum 63:3942-51. 2011
    To study the effect of the innate cytokine macrophage migration inhibitory factor (MIF) on the susceptibility and severity of systemic lupus erythematosus (SLE) in a multinational population of 1,369 Caucasian and African American patients...
  80. doi Macrophage migration inhibitory factor increases cell motility and up-regulates αvβ3 integrin in human chondrosarcoma cells
    Chun yi Lee
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    J Cell Biochem 113:1590-8. 2012
    The macrophage migration-inhibitory factor (MIF) is a pro-inflammatory cytokine first known for its effect on macrophage migration and activation...
  81. doi Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis
    Ruiping Liu
    Department of Orthopedics, the Affiliated Hospital of Nanjing Medical University, Changzhou Second People s Hospital, Changzhou, China
    Mol Biol Rep 39:6915-22. 2012
    b>Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory mediator. It plays an important role part in the pathogenesis of several inflammatory and immune diseases...
  82. doi Macrophage migration inhibitory factor is elevated in obese adolescents
    Uran Kamchybekov
    Friedrich Schiller University, Clinic of Internal Medicine I, Jena, Germany
    Arch Physiol Biochem 118:204-9. 2012
    The prevalence of obesity in childhood and adolescence is continuing rising. Macrophage migration inhibitory factor (MIF) participates in inflammatory and immune responses as a pro-inflammatory cytokine...
  83. pmc Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease
    Jun Nishihira
    Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido, Japan
    Ann N Y Acad Sci 1271:53-7. 2012
    b>Macrophage migration inhibitory factor (MIF) is a unique protein that participates in inflammation, immune responses, and cell growth...
  84. pmc Macrophage migration inhibitory factor (MIF): genetic evidence for participation in early onset and early stage rheumatoid arthritis
    M A Llamas-Covarrubias
    Functional Immunogenetics Group and PhD Program in Biomedical Sciences, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Cytokine 61:759-65. 2013
    b>Macrophage migration inhibitory factor (MIF) is an upstream pro-inflammatory cytokine that is associated with the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA)...
  85. pmc Dysregulated D-dopachrome tautomerase, a hypoxia-inducible factor-dependent gene, cooperates with macrophage migration inhibitory factor in renal tumorigenesis
    Vinay Pasupuleti
    From the Departments of Radiation Oncology
    J Biol Chem 289:3713-23. 2014
    ..We recently described a role for the macrophage migration inhibitory factor (MIF) in ccRCC as an autocrine-signaling molecule with elevated expression in tumor tissues and in ..
  86. ncbi The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor
    F Y Zeng
    Abteilung Glykobiochemie und Angewandte Tumorlektinologie, Philipps Universitat, Marburg, Germany
    Arch Biochem Biophys 303:74-80. 1993
    ..major sarcolectin-binding protein is identical to that deduced from the cDNA sequence of a human macrophage migration inhibitory factor (MIF), starting from its third amino acid, over the determined stretch of 22 amino acids...
  87. pmc Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor
    H W Sun
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:5191-6. 1996
    b>Macrophage migration inhibitory factor (MIF) was the first cytokine to be described, but for 30 years its role in the immune response remained enigmatic...
  88. pmc A proinflammatory cytokine inhibits p53 tumor suppressor activity
    J D Hudson
    Unit of Cancer Biology, Institute of Child Health, London WC1N 1EH, United Kingdom
    J Exp Med 190:1375-82. 1999
    ..In both screens, we isolated cDNAs encoding macrophage migration inhibitory factor (MIF), a cytokine that was shown previously to exert both local and systemic proinflammatory ..
  89. ncbi Macrophage migration inhibitory factor evaluation compared with prostate specific antigen as a biomarker in patients with prostate carcinoma
    Katherine L Meyer-Siegler
    Research and Development, Bay Pines Veterans Administration Medical Center, Bay Pines, Florida 33744, USA
    Cancer 94:1449-56. 2002
    ..The objective of this study was to evaluate the clinical usefulness of serum evaluation of the cytokine macrophage migration inhibitory factor (MIF) in patients undergoing routine prostate specific antigen (PSA) screening.
  90. ncbi Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis
    Ali Akoum
    Département d obstétrique gynécologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 77:989-94. 2002
    To assess spontaneous and stimulated secretion of monocyte chemotactic protein-1 (MCP-1) and macrophage migration inhibitory factor (MIF) by peritoneal macrophages in women with and without endometriosis.
  91. ncbi Macrophage migration inhibitory factor gene polymorphism is associated with sarcoidosis in biopsy proven erythema nodosum
    Mahsa M Amoli
    ARC Epidemiology Unit, Manchester University Medical School, United Kingdom
    J Rheumatol 29:1671-3. 2002
    To assess whether polymorphism of the macrophage migration inhibitory factor (MIF) gene at the position -173 is implicated in the development of sarcoidosis.
  92. pmc Release of macrophage migration inhibitory factor and CXCL8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection
    Ute Arndt
    Institute of Immunology, Philipps University, Marburg, Germany
    J Virol 76:9298-306. 2002
    ..In addition to the release of CXCL8/IL-8, we obtained a massive release of macrophage migration inhibitory factor (MIF) from virus-infected lung cells...
  93. ncbi Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis
    Rachelle Donn
    Epidemiology Unit, Arthritis Research Campaign, University of Manchester, Manchester, UK
    Arthritis Rheum 46:2402-9. 2002
    To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with juvenile idiopathic arthritis (JIA).
  94. ncbi Macrophage migration inhibitory factor
    Elias Lolis
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Expert Opin Ther Targets 7:153-64. 2003
    b>Macrophage migration inhibitory factor (MIF) is a ubiquitous protein that is found in virtually all cells...
  95. pmc MIF signal transduction initiated by binding to CD74
    Lin Leng
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St, P O Box 208031, New Haven, CT 06520 8031, USA
    J Exp Med 197:1467-76. 2003
    b>Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive immunity...
  96. ncbi Macrophage migration inhibitory factor: a regulator of innate immunity
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Nat Rev Immunol 3:791-800. 2003
    For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity...
  97. ncbi Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques
    Yao zhong Kong
    Department of Medicine, The First People s Foshan Hospital, Foshan, Guangdong, China
    Atherosclerosis 178:207-15. 2005
    b>Macrophage migration inhibitory factor (MIF) has been shown to participate in both experimental and human atherogenesis. Expression of MMP-9 has been shown to play a role in the instability of atherosclerotic plaque...
  98. ncbi Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism
    Barry J Plant
    F R C P I, Department of Medicine and Therapeutics, The Education Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Am J Respir Crit Care Med 172:1412-5. 2005
    b>Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It contributes toward an exaggerated gram-negative inflammatory response via its ability to induce Toll-like receptor-4 expression...
  99. ncbi Macrophage migration inhibitory factor is a determinant of hypoxia-induced apoptosis in colon cancer cell lines
    Kangshen Yao
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 11:7264-72. 2005
    ..to identify novel genes mediating sensitivity to hypoxia-induced apoptosis and isolated macrophage migration inhibitory factor (MIF) from the hypoxia-conditioned cell lines...
  100. ncbi Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events
    Ellen J Beswick
    Department of Pediatrics, University of Texas, Galveston, TX 77555, USA
    J Immunol 176:6794-801. 2006
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has recently been implicated in carcinogenesis...
  101. pmc CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex
    Xuerong Shi
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:595-606. 2006
    The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident...

Research Grants63

  1. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
    ..Chronic inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
  2. CHANGHYON CHRIS YUN; Fiscal Year: 2015
    ..including c-Myc, cyclin D, hypoxia-inducible factor (HIF)-1?, HIF-2?, cyclooxygenase-2, and macrophage migration inhibitory factor (MIF)...
  3. PATRICIA JEAN JOHNSON; Fiscal Year: 2014
    ..We have recently identified a secreted T. vaginalis homologue of the inflammatory cytokine, human macrophage migration inhibitory factor (MIF)...
  4. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
    ..b>Macrophage migration inhibitory factor (MIF) is a pleiotropi cytokine which is produced by variety of cells, including activated ..
  5. Thomas Yoonsang Cho; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Abstract Macrophage migration inhibitory factor (MIF) plays an important role for the recruitment of innate and adaptive immune cells to the place of inflammation...
  6. Pedro L Vera; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Experimental evidence supports the pro-inflammatory effect of Macrophage Migration Inhibitory Factor (MIF) in bladder inflammation, but how MIF mediates bladder inflammation is poorly understood...
  7. Laura E Nagy; Fiscal Year: 2016
    ..Using a pre- clinical mouse model of chronic ethanol exposure, we have identified macrophage migration inhibitory factor (MIF) as an important contributor to ethanol-induced steatosis and inflammation...
  8. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
  9. Arthur A Vandenbark; Fiscal Year: 2016
    ..its expression on the monocyte cell surface and blocking the inflammatory effects of macrophage migration inhibitory factor (MIF) that is a key pathogenic cytokine for EAE and MS...
  10. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012
    ..The pluripotential cytokine MIF (macrophage migration inhibitory factor) has described roles in regulating changes in cardiomyocyte glucose metabolism observed in the ..
  11. MEREDITH A GREENE; Fiscal Year: 2016
    ..b>Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that has been studied for its role in the immune system and in ..
  12. Yatrik M Shah; Fiscal Year: 2016
    ..3) The proinflammatory mediators, macrophage migration inhibitory factor (MIF) and prostaglandin E2 (PGE2) are early initiating factors in HIF2a-induced colon inflammation...
  13. Amplification of tumor hypoxic responses by MIF-dependent HIF stabilization
    Robert A Mitchell; Fiscal Year: 2013
    ..We recently discovered that macrophage migration inhibitory factor (MIF), one of the oldest cytokines ever described, is elevated in PDAC patient's plasma and ..
  14. MIHAELA GUEORGUIEVA GADJEVA; Fiscal Year: 2016
    ..Despite the promising studies conducted during my current R21 funding period which showed that macrophage migration inhibitory factor (MIF) has an unappreciated importance in regulating innate immune responses to P...
  15. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
  16. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..recently introduced a novel paradigm for AMPK activation, based on our discovery that the cytokine macrophage migration inhibitory factor (MIF) has an autocrine/paracrine effect to amplify AMPK activation during ischemia...
  17. Rituparna Das; Fiscal Year: 2014
    ..My preliminary data demonstrate an important role for macrophage migration inhibitory factor (MIF), a cytokine and upstream mediator of the innate immune response, in pneumococcal infection...
  18. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    Colin Sumners; Fiscal Year: 2013
    ..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive ..
  19. Edmund J Miller; Fiscal Year: 2016
    ..of a previously unrecognized, clinically relevant interaction between a proinflammatory cytokine [Macrophage Migration Inhibitory Factor (MIF)] and a thyroid hormone [Thyroxine (T4)] in PAH...
  20. Safe and Efficacious Oral MIF Inhibitors for Rheumatoid Arthritis Treatment
    ANDERSON GAWECO; Fiscal Year: 2012
    ..Selective inhibition of macrophage migration inhibitory factor [MIF] has been target validated demonstrating unprecedented superior safety and efficacy in ..
  21. Molecular characterization of a hookworm Macrophage Migration Inhibitory Factor
    Jon J Vermeire; Fiscal Year: 2010
    ..We have identified an orthologue of the inflammatory mammalian cytokine macrophage migration inhibitory factor (MIF) from the human hookworm Ancylostoma ceylanicum...
  22. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this proposal is to examine the role of macrophage migration inhibitory factor (MIF) in the regulation of osteoclastogenesis...
  23. Developing Small MIF Inhibitors for Rheumatoid Arthritis
    Christian Grant; Fiscal Year: 2013
    ..being developed at the academic partner (The Feinstein Institute for Medical Research), targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine whose dysregulation underlies many autoimmune diseases...
  24. Colin Sumners; Fiscal Year: 2014
    ..We have identified macrophage migration inhibitory factor in the brain as a regulator that helps to keep blood pressure in check and stop it from exceeding ..
  25. Orchestration of breast cancer osteolytic bone metastasis by MIF
    Jessica M Grunda; Fiscal Year: 2013
    ..of medulloblastoma bone metastasis generated by our laboratory as a 'discovery tool', macrophage migration inhibitory factor (MIF) was identified as a factor potentially orchestrating the development of breast cancer ..
  26. Richard F Loeser; Fiscal Year: 2014
    ..The objective of this exploratory and developmental (R21) project is to determine the role of macrophage migration inhibitory factor (MIF) in the development of osteoarthritis (OA) in mice and obtain data on MIF function in human ..
  27. William L Jorgensen; Fiscal Year: 2016
    ..Three specific biomolecular targets are addressed: HIV-1 reverse transcriptase (HIV-RT), macrophage migration inhibitory factor (MIF), and tyrosyl-DNA phosphodiesterase 1 (Tdp1)...
  28. Regulators of Endothelial Cell Apoptosis in LPS-Induced Acute Lung Injury
    Rachel L Damico; Fiscal Year: 2012
    ..Further, her work demonstrates that macrophage migration inhibitory factor (MIF) is a determinant of EC responses to LPS...
  29. Lara A Ray; Fiscal Year: 2014
    ..Ibudilast (IBUD) is a glial cell modulator that inhibits phosphodiesterases (PDE) -4 and -10 and macrophage migration inhibitory factor (MIF)...
  30. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    KAREN G ANTHONY; Fiscal Year: 2013
    ..RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF)...
  31. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Here, we will examine how the lung can be detrimental to the heart during sepsis. Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, ..
  32. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
  33. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    Karen Anthony; Fiscal Year: 2009
    ..with rheumatoid arthritis (RA), which will act by reducing the inflammatory response triggered by macrophage migration inhibitory factor (MIF). RA afflicts up to 4 million people in the U.S...
  34. POR In Inherited Metabolic Liver Diseases
    Pramod Mistry; Fiscal Year: 2009
    ..severity with functional polymorphisms in genes encoding the cytokines that are elevated in GD: Macrophage migration inhibitory factor (MIF), IL 6, IL 10, TNF alpha and TGF beta. 2...
  35. Potential Role of H. Pylori-induced MIF in Gastric Cancer
    ELLEN BESWICK; Fiscal Year: 2009
    ..H. pylori induces macrophage migration inhibitory factor (MIF) production from gastric epithelial cells, and MIF production is an important factor in many ..
  36. HEMOZOIN AND MALARIA PATHOGENESIS
    JAMES MARTINEY; Fiscal Year: 1999
    ..We have preliminary data demonstrating the release of large amounts of macrophage migration inhibitory factor (MIF) by macrophages after ingestion of hemozoin or parasitized erythrocytes...
  37. GIF regulation of B cells and CD4 cells
    Katsuji Sugie; Fiscal Year: 2003
    ..by a single gene in the genome and its nucleotide sequence is identical is that published for macrophage migration inhibitory factor (MIF). MIF(GIF)-/- mice show enhanced susceptibility to Leishmania major...
  38. MACROPHAGE PROLIFERATION AND ACTIVATION
    John Hadden; Fiscal Year: 1980
    ..Sephadex chromatography indicates an approximate molecular weight similar to that of migration inhibitory factor (MIF); however, vacuum dialysis prior to chromatography removes MIF and, therefore, distinguishes between the two ..
  39. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..b>Macrophage migration inhibitory factor (MIF) is an immunohormonal molecule that overrides the effect of cortisol on the GR...
  40. REGULATION OF MACROPHAGE MOTILITY BY COMPLEMENT
    Celso Bianco; Fiscal Year: 1980
    ..derived stimuli which induce migration or local retention and their relationship to MIF (macrophage migration inhibitory factor)...
  41. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF) is a unique molecule that functions as a cytokine and a hormone, and is induced by infections and psychological stress in animal models...
  42. The role of MIF in hookworm infection and disease
    Michael Cappello; Fiscal Year: 2009
    ..A eDNA corresponding to a homologue of the mammalian cytokine Macrophage Migration Inhibitory Factor (MIF) has recently been cloned from the human hookworm Ancylostoma ceylanicum...
  43. MOLECULES INVOLVED IN MACROPHAGE RESPONSES TO LYMPHOKINE
    David Liu; Fiscal Year: 1990
    ..This proposal is aimed at the dissection of the interaction of one lymphokine, migration inhibitory factor (MIF), with its target cell the macrophage...
  44. Novel MLCK-MIF Interaction in Endothelium
    Ari Zaiman; Fiscal Year: 2002
    ..system, the N-terminal portion of EC MLCK was found to interact with a proinflammatory cytokine, macrophage migration inhibitory factor (MIF), a regulator of innate and acquired immunity with a pathologic role in ARDS, sepsis, and ..
  45. INITIATION OF T CELL IMMUNE RESPONSES IN GUT MUCOSA
    Subhash Gautam; Fiscal Year: 1990
    ..adoptively transfer DH, to develop hapten induced T cell proliferation, and to produce migration inhibition factor (MIF) will be examined...
  46. ASTROCYTES AND MICROGLIA IN EPILEPSY
    Donald Born; Fiscal Year: 2000
    ..directly with lipopolysaccharide (a systemic macrophage promoter) or macrophage migration inhibition factor (MIF) during kainic acid induction of epilepsy...
  47. Migration Inhibitory Factor in the Progression of EAE
    Caroline C Whitacre; Fiscal Year: 2010
    ..Migration inhibitory factor (MIF) has recently been re-discovered as an inducer of pro- inflammatory cytokines and an antagonist of glucocorticoid ..
  48. Roles of MIF and iNOS in SLE-associate inflammation
    Michael Hickey; Fiscal Year: 2007
    ..preliminary data suggests the involvement of mediators such as nitric oxide (NO) and the cytokine macrophage migration inhibitory factor (MIF) in the modulation of leukocyte-endothelial interactions...
  49. A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary study
    Elizabeth D Mellins; Fiscal Year: 2013
    ..Pro-inflammatory cytokines that are principally monocyte-derived, including IL-18, MIF, IL-6 and IL-1, are implicated in SJIA pathogenesis by transcriptional analysis and other studies...
  50. Sophia Ran; Fiscal Year: 2014
    ..Consistent with hyperactive NF-?B signaling, we found that NF-?B-inducing factors IL-1[unreadable], MIF and KC/CXCL1 are overexpressed in pro-lymphangiogenic breast tumor lines and act in concert with a VEGFR-3 specific ..
  51. RICHARD J BUCALA; Fiscal Year: 2016
    ..Our research has focused on the role of the cytokine MIF, which we initially cloned together with its two-component receptor and found to sustain inflammatory responses by ..
  52. Regulation of CXCR4 by cognate and non-cognate ligands
    Elias Lolis; Fiscal Year: 2013
    ..More recently, a non-cognate protein, macrophage migration inhibitory protein (MIF), was reported to functionally activate CXCR4. We verified that MIF and CXCR4 interact with each other...
  53. Diane Bimczok; Fiscal Year: 2015
    ..to chronic inflammation and gastric autoimmunit;and (3) Determine whether gastric DC secretion of IL-8 and MIF promotes epithelial cell proliferation through the CXCR2-EGF-R axis in H. pylori gastritis...
  54. Jianqing Fan; Fiscal Year: 2014
    ..activation and teratoma development;and to unveil how the human MIFpolymorphisms associated with the serum MIF concentration in order to select patients for safe celltransplantation...
  55. Promotion of Angiogenesis in Lung Cancer by MIF
    Douglas A Arenberg; Fiscal Year: 2010
    ..In our initial proposal we studied the promotion of angiogenesis in lung cancer by the cytokine MIF, and determined that tumors can create an angiogenic milieu by activating one of several different pathways...
  56. PATHWAYS TO INFLAMMATORY BOWEL DISEASE
    CORNELIS P TERHORST; Fiscal Year: 2012
    This application seeks funding for studies aimed at evaluating how the cytokine MIF and the receptor / counter-receptor pair CD48/CD244 control the innate immune responses involved in the development of experimental colitis...
  57. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..CNS are involved in morphine tolerance-dependence and abstinence processes and (c) peptides like Pro-Leu-Gly-NH2 (MIF) and cyclo(Leu-Gly) (CLG) inhibit morphine tolerance-dependence and abstinence processes by affecting DA and opiate ..
  58. Paul J May; Fiscal Year: 2016
    ..The preganglionic and MIF motor neuron groups are found in the perioculomotor region...
  59. CONTROL OF MSH RELEASE AND ROLE OF MIF AND MSH
    ABBA KASTIN; Fiscal Year: 1980
    ..We plan to continue to study the MSH-release inhibiting factor (MIF) and its interactions with other systems...
  60. COLLEEN MARIE CEBULLA; Fiscal Year: 2016
    ..my preliminary proteomic analysis of retina and vitreous in an animal model of PVR has identified up-regulation of MIF, as well as other candidates, in PVR...
  61. UltraVIEW VoX spinning disk confocal for core facility
    Rebecca M Williams; Fiscal Year: 2012
    ..The instrument will be managed under the Microscopy and Imaging Facility (MIF), which houses a variety of optical imaging stations, from widefield microscopes to point scanning confocals to ..
  62. Ocular Motor Adaptation in Health and Disease
    HOWARD SHANN CHERNG YING; Fiscal Year: 2013
    ..Specifically, we examine the role of global multiply-innervated fibers (MIF's), which have been previously overlooked because of their lack of fast twitch fibers, and their palisade ..
  63. Sepsis syndrome and adenosine A2A receptor activation
    WILLIAM SCHELD; Fiscal Year: 2007
    ..implicated in the pathophysiology of septic shock, including TNF?, IL-1, IL-6, IL-8, IL-10, IL-12, interferon-?, MIF, HMGB1, and TREM-1...