MID1IP1

Summary

Gene Symbol: MID1IP1
Description: MID1 interacting protein 1
Alias: G12-like, MIG12, S14R, STRAIT11499, THRSPL, mid1-interacting protein 1, MID1 interacting G12-like protein, MID1 interacting protein 1 (gastrulation specific G12-like), gastrulation specific G12 homolog, spot 14-R, spot 14-related protein
Species: human

Top Publications

  1. pmc Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway
    Abhik Shah
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Bioinformatics 10:433. 2009
  2. pmc Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon
    Neil I Bower
    Scottish Oceans Institute, School of Biology, University of St Andrews, St Andrews, Fife, United Kingdom
    Physiol Genomics 42:114-30. 2010
  3. doi A genome-wide association study for canine cryptorchidism in Siberian Huskies
    X Zhao
    Department of Animal Science, Iowa State University, Ames, IA, USA
    J Anim Breed Genet 131:202-9. 2014
  4. pmc ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line
    Chanachai Sae-Lee
    Clinical Molecular Pathology Laboratory, Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    PLoS ONE 11:e0147411. 2016
  5. pmc Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis
    Qifei Wang
    Department of Scoliosis, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Mol Med Rep 13:4636-42. 2016
  6. pmc Homozygous and heterozygous GH transgenesis alters fatty acid composition and content in the liver of Amago salmon (Oncorhynchus masou ishikawae)
    Manabu Sugiyama
    Nihon University College of Bioresource Sciences, Kameino 1866, Fujisawa 252 0880, Japan
    Biol Open 1:1035-42. 2012
  7. pmc PPARγ maintains ERBB2-positive breast cancer stem cells
    X Wang
    Department of Biomedical Sciences, Cancer Research Center, University at Albany, State University of New York, Rensselaer, NY, USA
    Oncogene 32:5512-21. 2013
  8. pmc Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2
    Sungjo Park
    Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, MN, USA
    J Mol Recognit 26:679-88. 2013
  9. pmc Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules
    Caterina Berti
    Telethon Institute of Genetics and Medicine, 80131 Naples, Italy
    BMC Cell Biol 5:9. 2004
  10. pmc Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development
    Julie M Hayes
    Department of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University Station C1000, University of Texas, Austin, TX 78712, USA
    Dev Biol 312:115-30. 2007

Research Grants

  1. Joseph L Goldstein; Fiscal Year: 2016

Scientific Experts

  • Tsukasa Mori
  • Abhik Shah
  • Caterina Berti
  • Neil I Bower
  • Joseph L Goldstein
  • Chai Wan Kim
  • Qifei Wang
  • Chanachai Sae-Lee
  • X Zhao
  • Sungjo Park
  • X Wang
  • Manabu Sugiyama
  • Jun Inoue
  • Hyock Joo Kwon
  • Christopher L Colbert
  • Derrick L Aipoalani
  • Young Ah Moon
  • Makoto Suzuki
  • Jay D Horton
  • Naoto Ueno
  • W M Casey
  • Julie M Hayes
  • Naravat Poungvarin
  • Zifang Huang
  • Hengwei Fan
  • Lawrence Chan
  • Xiang Lin
  • Chaofan Xie
  • Kanya Moolsuwan
  • Junlin Yang
  • M Rothschild
  • S Onteru
  • D Garrick
  • M Saatchi
  • Andre Terzic
  • Y Sun
  • J Wong
  • In Wook Hwang
  • Nicolas J Niederlander
  • Tatsuya Kato
  • Enoch Y Park
  • Yu Makishima
  • Ester Perales-Clemente
  • D S Conklin
  • Yoichiro Kitani
  • Fumio Takenaga
  • Goshi Yamamoto
  • Kazuo Araki
  • Hiroyuki Nagoya
  • Hiroyuki Okamoto
  • Tetsuji Masaoka
  • Emina Ikeuchi
  • Kohei Yamasaki
  • Tomoko Nishimaki-Mogami
  • Ryuichiro Sato
  • Yoko Fujiwara
  • Shin ichi Satoh
  • Makoto Shimizu
  • Dong Cheng
  • William B McKean
  • Yusuke Hara
  • Brennon L O'Callaghan
  • Johann Deisenhofer
  • Cary N Mariash
  • Chiyo Takagi
  • Howard C Towle
  • Maya Palnitkar
  • Kevin Fitzgerald
  • Sahng Wook Park
  • Douglas G Mashek
  • Takamasa S Yamamoto
  • Lisa Henry
  • L Yoon
  • T Brodie
  • H Ni
  • H L Jordan
  • N F Cariello
  • Tae Joo Park
  • Philip B Abitua
  • Matthew W Grow
  • Emily R Herrington
  • John B Wallingford
  • Atsushi Kitayama
  • Su Kyoung Kim

Detail Information

Publications16

  1. pmc Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway
    Abhik Shah
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Bioinformatics 10:433. 2009
    ..The topology of a biological pathway provides clues as to how a pathway operates, but rationally using this topology information with observed gene expression data remains a challenge...
  2. pmc Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon
    Neil I Bower
    Scottish Oceans Institute, School of Biology, University of St Andrews, St Andrews, Fife, United Kingdom
    Physiol Genomics 42:114-30. 2010
    ..expression during the proliferative phase of the culture (FOXD1, DRG1) or as cells differentiated (SMYD1, RTN1, MID1IP1, HSP90A, novel transcript GE617747)...
  3. doi A genome-wide association study for canine cryptorchidism in Siberian Huskies
    X Zhao
    Department of Animal Science, Iowa State University, Ames, IA, USA
    J Anim Breed Genet 131:202-9. 2014
    ..on CFA24, ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif, 20) on CFA27 and MID1IP1 (MID1 interacting protein 1) on CFAX are known to be functionally related to extracellular matrix remodelling, which might be ..
  4. pmc ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line
    Chanachai Sae-Lee
    Clinical Molecular Pathology Laboratory, Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    PLoS ONE 11:e0147411. 2016
    ..and necessary for regulation of Eno1, Pklr, Mdh1, Me1, Pdha1, Acly, Acaca, Fasn, Elovl6, Gpd1, Cpt1a, Rgs16, Mid1ip1,Txnip, and Chrebpβ. Expression of Chrebpα and Srebp1c were not changed by caChREBP or dnChREBP...
  5. pmc Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis
    Qifei Wang
    Department of Scoliosis, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Mol Med Rep 13:4636-42. 2016
    ..study was to evaluate the different expression levels of thyroid hormone responsive (THRSP; Spot14)/S14 related, Mig12 (S14R) during bone marrow mesenchymal stem cell (BM-MSC) adipogenesis in adolescent idiopathic scoliosis (AIS) ..
  6. pmc Homozygous and heterozygous GH transgenesis alters fatty acid composition and content in the liver of Amago salmon (Oncorhynchus masou ishikawae)
    Manabu Sugiyama
    Nihon University College of Bioresource Sciences, Kameino 1866, Fujisawa 252 0880, Japan
    Biol Open 1:1035-42. 2012
    ..gene expression profiling was performed using liver tissues from Tg/Tg and +/+ fish, and showed that Mid1 interacting protein 1 (Mid1ip1), which is an important factor to activate Acetyl-CoA carboxylase (ACC), was down-regulated in ..
  7. pmc PPARγ maintains ERBB2-positive breast cancer stem cells
    X Wang
    Department of Biomedical Sciences, Cancer Research Center, University at Albany, State University of New York, Rensselaer, NY, USA
    Oncogene 32:5512-21. 2013
    ..analyses show that GW9662 treatment suppresses the expression of several lipogenic genes, including ACLY, MIG12, FASN and NR1D1, and the stem-cell related genes KLF4 and ALDH in BT474 cells...
  8. pmc Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2
    Sungjo Park
    Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, MN, USA
    J Mol Recognit 26:679-88. 2013
    ..Spot14, a thyroid hormone responsive protein, and Mig12, a Spot14 paralog, have recently been identified as regulators of fatty acid synthesis targeting ACC1, a ..
  9. pmc Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules
    Caterina Berti
    Telethon Institute of Genetics and Medicine, 80131 Naples, Italy
    BMC Cell Biol 5:9. 2004
    ..Mid1 acts as an E3 ubiquitin ligase, regulating PP2A degradation on microtubules...
  10. pmc Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development
    Julie M Hayes
    Department of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University Station C1000, University of Texas, Austin, TX 78712, USA
    Dev Biol 312:115-30. 2007
    ..b>Mig12-GFP localizes very strongly to the base of cilia and confocal imaging of this construct allows for simple ..
  11. ncbi Correlation analysis of gene expression and clinical chemistry to identify biomarkers of skeletal myopathy in mice treated with PPAR agonist GW610742X
    W M Casey
    GlaxoSmithKline, US Research and Development, Safety Assessment, NC 27709, USA
    Biomarkers 13:364-76. 2008
    ..transducer and activator of transcription 3), Socs3 (suppressor of cytokine signalling 3) and Mid1ip1 (Mid1 interacting protein 1)...
  12. pmc Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis
    Derrick L Aipoalani
    Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, Minnesota 55455, USA
    Endocrinology 151:2071-7. 2010
    ..was postulated that this difference could be due to the expression of a paralogous gene called S14R (S14 related; Mig12) in the liver but not mammary tissue...
  13. pmc Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis
    Chai Wan Kim
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:9626-31. 2010
    ..Here, we show that MIG12, a 22 kDa cytosolic protein of previously unknown function, binds to ACC and lowers the threshold for citrate ..
  14. doi MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization
    Makoto Suzuki
    Division of Morphogenesis, Department of Developmental Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki 444 8585, Aichi, Japan
    Development 137:2329-39. 2010
    ..We also found that the xMIDs and their interacting protein Mig12 were coordinately required for microtubule stabilization during remodeling of the neural plate...
  15. pmc Crystal structure of Spot 14, a modulator of fatty acid synthesis
    Christopher L Colbert
    Department of Biochemistry and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 107:18820-5. 2010
    ..65 Å and biochemical data showing that S14 can form heterodimers with MIG12. MIG12 modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the ..
  16. doi Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation
    Jun Inoue
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Mol Endocrinol 25:995-1005. 2011
    ..We describe a novel LXR target, midline-1-interacting G12-like protein (MIG12), which has been recently identified as an acetyl-coenzyme A carboxylase-binding protein...

Research Grants1

  1. Joseph L Goldstein; Fiscal Year: 2016
    ..required for ghrelin's activity in controlling appetite and blod sugar;7) identification of a protein, MIG12, that activates fatty acid synthesis in liver;8) discovery of 25-hydroxycholesterol as an immunoregulatory sterol ..