methionine synthase reductase

Summary

Gene Symbol: methionine synthase reductase
Description: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Alias: MSR, cblE, methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing), methionine synthase reductase, mitochondrial
Species: human

Top Publications

  1. doi Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes
    Esko J Wiltshire
    Department of Paediatrics and Child Health, University of Otago Wellington, Wellington South, New Zealand
    Pediatr Diabetes 9:348-53. 2008
  2. pmc Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
    D Leclerc
    Medical Research Council Group in Medical Genetics, The Montreal Children s Hospital, McGill University Health Centre, Montreal, PQ, Canada H3Z 2Z3
    Proc Natl Acad Sci U S A 95:3059-64. 1998
  3. ncbi Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism
    A Wilson
    MRC Group in Medical Genetics, Montreal Children s Hospital, Canada
    Hum Mol Genet 8:2009-16. 1999
  4. ncbi Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    S J James
    Food and Drug Administration National Center for Toxicological Research, the Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Am J Clin Nutr 70:495-501. 1999
  5. ncbi 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    L D Botto
    Birth Defects and Pediatric Genetics Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 151:862-77. 2000
  6. ncbi Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation
    H Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 276:35558-63. 2001
  7. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
  8. ncbi MTRR and MTHFR polymorphism: link to Down syndrome?
    Valerie B O'Leary
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Am J Med Genet 107:151-5. 2002
  9. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
  10. pmc Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
    Marie Therese Doolin
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Hum Genet 71:1222-6. 2002

Research Grants

  1. GENETIC RISK FACTORS FOR HYPERHOMOCYSTEINEMIA
    ROY GRAVEL; Fiscal Year: 2006
  2. Conversion of Inactive Cobalamins to Coenzyme B12
    Thomas Bobik; Fiscal Year: 2005
  3. Pharmacogenetics of Methotrexate Therapy in Arthritis
    ALEXANDER WHITEHEAD; Fiscal Year: 2006
  4. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
  5. Kinetic Analysis of Methionine Synthase Reductase
    KIRSTEN WOLTHERS; Fiscal Year: 2004
  6. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
  7. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
  8. Ann E Jerse; Fiscal Year: 2014
  9. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2009
  10. Significance of four methionine sulfoxide reductases in Staphylococcus aureus
    Vineet Kumar Singh; Fiscal Year: 2010

Detail Information

Publications207 found, 100 shown here

  1. doi Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes
    Esko J Wiltshire
    Department of Paediatrics and Child Health, University of Otago Wellington, Wellington South, New Zealand
    Pediatr Diabetes 9:348-53. 2008
    ..We aimed to determine whether polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are risk factors for early microvascular disease in a large group of adolescents with ..
  2. pmc Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
    D Leclerc
    Medical Research Council Group in Medical Genetics, The Montreal Children s Hospital, McGill University Health Centre, Montreal, PQ, Canada H3Z 2Z3
    Proc Natl Acad Sci U S A 95:3059-64. 1998
    ..to predicted binding sites for FMN, FAD, and NADPH, we have cloned a cDNA corresponding to the "methionine synthase reductase" reducing system required for maintenance of the methionine synthase in a functional state...
  3. ncbi Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism
    A Wilson
    MRC Group in Medical Genetics, Montreal Children s Hospital, Canada
    Hum Mol Genet 8:2009-16. 1999
    b>Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia...
  4. ncbi Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    S J James
    Food and Drug Administration National Center for Toxicological Research, the Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Am J Clin Nutr 70:495-501. 1999
    ..Although advanced maternal age is a major risk factor for trisomy 21, most children with Down syndrome are born to mothers <30 y of age...
  5. ncbi 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    L D Botto
    Birth Defects and Pediatric Genetics Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 151:862-77. 2000
    ..g., cystathionine-beta-synthase and methionine synthase reductase)...
  6. ncbi Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation
    H Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 276:35558-63. 2001
    ..Identification of mutations in the gene encoding a putative methionine synthase reductase in the cblE class of patients with an isolated functional deficiency of methionine synthase suggested ..
  7. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
    ..One such enzyme, methionine synthase reductase (MTRR), maintains adequate levels of methylcob(III)alamin, the activated cofactor for methionine ..
  8. ncbi MTRR and MTHFR polymorphism: link to Down syndrome?
    Valerie B O'Leary
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Am J Med Genet 107:151-5. 2002
    ..genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome...
  9. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ....
  10. pmc Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
    Marie Therese Doolin
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Hum Genet 71:1222-6. 2002
    ..involved in homocysteine remethylation/methionine biosynthesis--methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G--provided evidence that both variants influence the risk of spina bifida via the maternal ..
  11. ncbi Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase
    Horatiu Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 41:13378-85. 2002
    b>Methionine synthase reductase (MSR) catalyzes the conversion of the inactive form of human methionine synthase to the active state of the enzyme...
  12. ncbi Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study
    Paul F Jacques
    Jean Mayer USDA, Human Nutrition Research Center on Aging at Tufts University, 711 Wasington Street, Boston, MA 02111, USA
    Atherosclerosis 166:49-55. 2003
    ..Common variants of two other enzymes involved in homocysteine metabolism, methionine synthase and methionine synthase reductase, have also been identified...
  13. ncbi Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Mol Genet Metab 78:216-21. 2003
    ..purpose of this study is to investigate whether gene polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) are involved in the risk for NTDs, specifically spina bifida...
  14. ncbi Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects
    A Zijno
    Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Carcinogenesis 24:1097-103. 2003
    ..acid, homocysteine and vitamin B12, and by the methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms was investigated in 191 healthy subjects...
  15. ncbi Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 12:1222-6. 2003
    ..and three polymorphisms in two genes that code for enzymes that require folate and B(12) as cofactors: methionine synthase reductase (MTRR) A66G and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C...
  16. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair insertion), and thymidylate ..
  17. ncbi Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant
    Jaimie D Vaughn
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 134:2985-90. 2004
    Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are important for homocysteine remethylation...
  18. ncbi cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression
    Petra Zavadakova
    Institute of Inherited Metabolic Diseases, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Hum Mutat 25:239-47. 2005
    ..enzyme might be activated by two different reducing systems, mutations were reported in only the methionine synthase reductase gene (MTRR) in cblE patients...
  19. ncbi Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    b>Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase (MTR)...
  20. ncbi No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers
    Abalo Chango
    INSERM U 724, Laboratory of Nutritional Genomics, ISAB Agrohealth, 60026 Beauvais, France
    Br J Nutr 94:166-9. 2005
    ..Recent evidence has suggested that 5,10-methylenetetrahydrofolate reductase (MTHFR) and/or methionine synthase reductase (MTRR) might contribute to the maternal risk of trisomy 21...
  21. ncbi Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tsukjii, Tokyo
    Nutr Cancer 53:42-50. 2005
    ..02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake. In conclusion, the study did not support the existing hypothesis of gene-nutrient interaction in colorectal carcinogenesis...
  22. pmc Human methionine synthase reductase is a molecular chaperone for human methionine synthase
    Kazuhiro Yamada
    4002 Life Sciences Institute, Department of Biological Chemistry, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Proc Natl Acad Sci U S A 103:9476-81. 2006
    Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins...
  23. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  24. ncbi MTRR 66A>G polymorphism in relation to congenital heart defects
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem Lab Med 44:1317-23. 2006
    ..The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role ..
  25. ncbi Genetic polymorphisms in folate metabolism and the risk of stomach cancer
    Fang Fang Zhang
    Division of Cancer Epidemiology and Genetics, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:115-21. 2007
    ..Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk...
  26. ncbi Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2452-8. 2007
    ..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk...
  27. ncbi Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses
    Jolanta Lissowska
    Department of Cancer Epidemiology and Prevention, Cancer Center and M Sklodowska Curie Institute of Oncology, Warsaw, Poland
    Int J Cancer 120:2696-703. 2007
    ..In conclusion, this report does not support a substantial overall association between the evaluated polymorphisms in the one-carbon metabolism pathway and breast cancer risk...
  28. pmc Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase
    C Lee Elmore
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Mol Genet Metab 91:85-97. 2007
    ..We have constructed a mouse model with a gene trap insertion in the Mtrr gene specifying methionine synthase reductase, an enzyme essential for the activity of methionine synthase...
  29. ncbi Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    Ase Fredriksen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Hum Mutat 28:856-65. 2007
    ..1286A>C (known as 1298A>C; p.Glu429Ala); methionine synthase (MTR) c.2756A>G (p.Asp919Gly); methionine synthase reductase (MTRR) c.66A>G (p.Ile22Met); methylenetetrahydrofolate dehydrogenase (MTHFD1) c.1958G>A (p...
  30. ncbi Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation
    Kirsten R Wolthers
    Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    Biochemistry 46:6696-709. 2007
    ..The C-terminal activation domain also interacts with methionine synthase reductase (MSR), a NADPH-dependent diflavin oxidoreductase required for the reductive regeneration of ..
  31. ncbi Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women
    P R Barbosa
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, SP, Brazil
    Eur J Clin Nutr 62:1010-21. 2008
    ..methylenetetrahydrofolate reductase (MTHFR) (C677T and A1298C), methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms and total homocysteine (tHcy), methylmalonic acid (MMA) and S-..
  32. ncbi One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
    ..as methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism and thus might impact on HNSCC ..
  33. ncbi Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease
    Laurent Peyrin-Biroulet
    INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre les Nancy, France
    Am J Gastroenterol 103:399-406. 2008
    ..The aim of this study was to evaluate the association of nutritional (folate, vitamin B12) and genetic (MTHFR, MTR, MTRR, TCN) determinants of homocysteine metabolism and of superoxide dismutase with Crohn's disease (CD)...
  34. ncbi Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer
    C Marchal
    Urology Department, Hospital Clinico Universitario, Virgen de la Victoria, Campus de Teatinos s n, Malaga 29010, Spain
    Eur J Surg Oncol 34:805-10. 2008
    ..reductase (MTHFR, 677CT and 1298AC), methionine synthase (MTR, 2756AC) and methionine synthase reductase (MTRR, 66AC) provoke variations in enzyme activity, which can lead to alterations in the metabolism of ..
  35. ncbi Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?
    I Terruzzi
    Division of Internal Medicine, Section of Nutrition Metabolism, San Raffaele Scientific Institute, 20132 Milano, Italy
    J Endocrinol Invest 30:747-53. 2007
    ..of methylene-tetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), betaine:homocysteine methyltransferase (BHMT G742A) and cystathionine beta-synthase (CBS ..
  36. doi Dietary vitamin B6 intake and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:171-82. 2008
    ..Evidence from larger cohort and experimental studies is now required to confirm and define the anticarcinogenic actions of vitamin B6 and to explore the mechanisms by which this effect is mediated...
  37. pmc Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China
    Shao shuai Wang
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Zhejiang Univ Sci B 9:93-9. 2008
    ..explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the ..
  38. doi Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Neurosci Lett 449:15-9. 2009
    ..reductase (MTHFR) 677C>T and 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G, and thymidylate synthase (TYMS) 28bp repeat and 1494del6...
  39. ncbi Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population
    Sun Young Kwak
    Department of Internal Medicine, College of Medicine, Pochon CHA University, Seongnam, South Korea
    Anticancer Res 28:2807-11. 2008
    ..Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) play an essential role in both DNA synthesis and methylation and polymorphisms in the MTHFR ..
  40. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  41. doi Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 18:3086-96. 2009
    ..The incomplete overlap between CIMP, MLH1 hypermethylation, and microsatellite instability indicates that these related "methylation phenotypes" may not be similar and should be investigated separately...
  42. pmc Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 21:331-45. 2010
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer...
  43. pmc MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Mol Med 16:425-32. 2010
    ..methyl-associated genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR) and methionine synthase reductase (MTRR), were analyzed in the same patient cohort to find a possible link between these genetic ..
  44. pmc Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome
    Adam E Locke
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    Genet Epidemiol 34:613-23. 2010
    ..folate pathway genes: 5,10-methylenetetrahyrdofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), cystathionine beta-synthase (CBS), and the reduced folate carrier (SLC19A1, RFC1)...
  45. pmc Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil
    Ana Paula Carneiro Brandalize
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Dis Markers 29:95-101. 2010
    ....
  46. doi MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic
    Barbara Pardini
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Mutat Res 721:74-80. 2011
    ..For MTRR, additional studies on larger populations are needed to clarify the possible role of variation in this gene in colorectal carcinogenesis...
  47. doi Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer
    Mladen Jokic
    Laboratory for Personalized Medicine, Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
    DNA Cell Biol 30:771-6. 2011
    ..Specific combinations of alleles of these two polymorphisms showed a protective but also a risk effect on colon cancer susceptibility...
  48. doi Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies
    Dong Han
    Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin 150081, China
    Mol Biol Rep 39:805-16. 2012
    b>Methionine synthase reductase (MTRR) gene is involved in tumorigenesis by regulating DNA methylation through activation of methionine synthase (MTR)...
  49. doi Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma
    José Luiz Miranda Guimarães
    Service of Oncohematology, Department of Clinical Oncology from Hospital Santa Rita Complexo Hospitalar Santa Casa, Grupo Hospitalar Conceição, Rua Capitão Pedro Werlang, 614, Partenon, Porto Alegre, Rio Grande do Sul, Cep 91530110, Brazil
    Tumour Biol 32:853-61. 2011
    ..of methylenetetrahydrofolate reductase (MTHFR A1298C and C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS 2R/3R) in 113 patients with sporadic colorectal ..
  50. doi Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression is epigenetically regulated by one-carbon metabolism in invasive duct cell carcinoma of breast
    Shaik Mohammad Naushad
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India
    Mol Cell Biochem 361:189-95. 2012
    ..CIMP phenotype of BNIP3 showed positive association with tubule formation (P = 0.034) and methionine synthase reductase (MTRR) A66G (P = 0...
  51. doi A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population
    W Zeng
    The Laboratory of Early Development and Injuries, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
    Genet Mol Res 10:2597-605. 2011
    ..b>Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine...
  52. doi Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population
    Jian Yuan Zhao
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Circulation 125:482-90. 2012
    Homocysteine is known to be an independent risk factor for congenital heart disease (CHD). Methionine synthase reductase (MTRR) is essential for the adequate remethylation of homocysteine, which is the dominant pathway for homocysteine ..
  53. doi MTRR 66A>G polymorphism as maternal risk factor for Down syndrome: a meta-analysis
    Marcia R Amorim
    Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
    Genet Test Mol Biomarkers 17:69-73. 2013
    ..Recent reports have investigated possible genetic factors that may increase maternal risk for DS. Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in ..
  54. ncbi A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
    A Wilson
    The Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    Mol Genet Metab 67:317-23. 1999
    ..We now report a polymorphism in methionine synthase reductase (MTRR), the enzyme that activates cobalamin-dependent methionine synthase...
  55. ncbi Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event
    Zoe Yates
    Academic Unit of Paediatrics and Obstetrics and Gynaecology, D Floor, Clarendon Wing, Leeds General Infirmary, University of Leeds, Leeds, West Yorkshire LS2 9NS, UK
    Mol Genet Metab 79:201-13. 2003
    ..and homocysteine remethylation via folate dependent methionine biosynthesis, namely 2756A-->G-MS/66A-->G-MSR and 677C-->T-MTHFR/1298A-->C-MTHFR...
  56. ncbi Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis
    Qiuling Shi
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:547-55. 2005
    ..Methionine synthase (MS; gene symbol, MTR) and methionine synthase reductase (MSR; gene symbol, MTRR) play important roles in the folate metabolism pathway...
  57. ncbi Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility
    Han Chul Lee
    Functional Genomics Lab, CHA Research Institute, Bundang Campus, College of Medicine, Pochon CHA University, Kyunggi Do, Republic of Korea
    Hum Reprod 21:3162-70. 2006
    ..We evaluated whether polymorphisms of these three enzymes are associated with non-obstructive male infertility...
  58. doi Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study
    Anna C Verkleij-Hagoort
    Department of Obstetrics, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Mol Genet Metab 94:112-9. 2008
    ..We investigated methionine synthase reductase (MTRR) and transcobalamin II (TC) genes and maternal intake and serum concentrations of vitamin B12 in ..
  59. pmc Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome
    N Fintelman-Rodrigues
    Departamento de Genetica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Dis Markers 26:155-61. 2009
    ..Our results suggest that maternal folate-related polymorphisms studied here have no influence on trisomy 21 susceptibility in subjects of Brazilian population...
  60. ncbi [A rare inborn error of intracellular processing of cobalamine presenting with microcephalus and megaloblastic anemia: a report of 3 children]
    P Muller
    HELIOS Krankenhaus Leisnig, Abteilung für Kinder und Jugendmedizin, Leisning
    Klin Padiatr 219:361-7. 2007
    Defects of methionine synthase or methionine synthase reductase result in an impaired remethylation of homocysteine to methionine...
  61. pmc Impeded electron transfer from a pathogenic FMN domain mutant of methionine synthase reductase and its responsiveness to flavin supplementation
    Carmen G Gherasim
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 47:12515-22. 2008
    b>Methionine synthase reductase (MSR) is a diflavin oxidoreductase that transfers electrons from NADPH to oxidized cobalamin and plays a vital role in repairing inactive cobalamin-dependent methionine synthase...
  62. ncbi Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1
    Horatiu Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 278:38310-4. 2003
    ..Genetic and biochemical studies have demonstrated that the soluble dual flavoprotein oxidoreductase, methionine synthase reductase, serves as a redox partner for methionine synthase in an NADPH-dependent reaction...
  63. doi Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex
    Kirsten R Wolthers
    Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    FEBS J 276:1942-51. 2009
    Human methionine synthase reductase (MSR), a diflavin enzyme, restores the activity of human methionine synthase through reductive methylation of methionine synthase (MS)-bound cob(II)alamin...
  64. pmc Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice
    Liyuan Deng
    Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, Montreal, Canada
    Mol Genet Metab 94:336-42. 2008
    ..b>Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme...
  65. pmc Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias
    Rowena G Matthews
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Clin Chem Lab Med 45:1700-3. 2007
    ..metabolism: cystathionine beta-synthase, methylenetetrahydrofolate reductase, methionine synthase and methionine synthase reductase. While each enzyme deficiency leads to murine hyperhomocyst(e)inemia, the accompanying metabolic ..
  66. ncbi Defects in human methionine synthase in cblG patients
    S Gulati
    Biochemistry Department, University of Nebraska, Lincoln 68588 0664, USA
    Hum Mol Genet 5:1859-65. 1996
    ..resulting in isolated functional methionine synthase deficiency fall into two complementation groups, cblG and cblE. Using biochemical approaches we demonstrate that one cblG patient has greatly reduced levels of methionine ..
  67. ncbi CblE type of homocystinuria: mild clinical phenotype in two patients homozygous for a novel mutation in the MTRR gene
    M A Vilaseca
    Hospital Sant Joan de Deu, Barcelona, Spain
    J Inherit Metab Dis 26:361-9. 2003
    ..clearly reduced production of methylcobalamin from 57Co-labelled cyanocobalamin indicated functional methionine synthase reductase deficiency due to the cblE defect...
  68. ncbi Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?
    Jean Louis Gueant
    INSERM 00 14, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine Nancy, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 41:1473-7. 2003
    ..reductase (MTHFR 677 C --> T and 1298 A --> C), of methionine synthase (MTR 2756 C --> G), methionine synthase reductase (MTRR 66 A --> G) and transcobalamin (TCN 776 C --> G)...
  69. ncbi A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease
    C A Brown
    Department of Pediatrics, Carolinas Medical Center, Charlotte, North Carolina, USA
    J Cardiovasc Risk 7:197-200. 2000
    b>Methionine synthase reductase (MTRR) catalyzes the regeneration of methylcobalamin, a cofactor of methionine synthase, an enzyme essential for maintaining adequate intracellular pools of methionine and tetrahydrofolate, as well as for ..
  70. ncbi [Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]
    Ya Ping Liao
    Department of Cell Biology, Bengbu Medical College, Bengbu 233030, China
    Yi Chuan 32:461-6. 2010
    ..explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), reduced folate carrier1 (RFC-1), methionine synthase (MTR) involved in folate metabolism and ..
  71. ncbi Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 28:1718-25. 2007
    ..methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate metabolism and thus might be suspected of ..
  72. doi MTRR A66G polymorphism and breast cancer risk: a meta-analysis
    Jia Hu
    Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 124:779-84. 2010
    b>Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk...
  73. ncbi Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A
    Peter L Rady
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0359, USA
    Am J Med Genet 107:162-8. 2002
    ..Compound heterozygosity for multiple polymorphic alleles may play a role in birth defects and vascular diseases...
  74. ncbi Gene polymorphism and folate metabolism: a maternal risk factor for Down syndrome
    Jayesh J Sheth
    Foundation for Research in Genetics and Encocrinology FRIGE, Genetics Center, Ahmedabad 380 015, India
    Indian Pediatr 40:115-23. 2003
    ....
  75. ncbi Disturbed visual system function in methionine synthase deficiency
    Charlotte M Poloschek
    Department of Paediatric Ophthalmology and Ophthalmogenetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Graefes Arch Clin Exp Ophthalmol 243:497-500. 2005
    Isolated functional methionine synthase deficiency occurs in the cblE and cblG defects of methylcobalamin metabolism and is one of a number of causes of severely elevated plasma homocysteine...
  76. ncbi Crystal structure and solution characterization of the activation domain of human methionine synthase
    Kirsten R Wolthers
    Faculty of Life Sciences, University of Manchester, UK
    FEBS J 274:738-50. 2007
    ..Fluorescence studies show that human activation domain interacts with the FMN-binding domain of human methionine synthase reductase (hMSR). This interaction is enhanced in the presence of S-adenosyl-methionine...
  77. ncbi High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    Klaus Meyer
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem 50:391-402. 2004
    ..Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism...
  78. pmc The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome
    C B Santos-Rebouças
    Departamento de Genetica, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Alcantara Gomes, Serviço de Genética, Rio de Janeiro, RJ, Brazil
    Dis Markers 25:149-57. 2008
    ..1298A>C polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and 66A>G in the methionine synthase reductase gene (MTRR) between 103 young mothers of Down syndrome (DS) individuals and 108 control mothers, whose ..
  79. pmc Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA study
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Mol Genet Metab 98:181-6. 2009
    ..metabolism: cystathionine beta-synthase (CBS) 844ins68, methionine synthase (MS) 2756A>G; methionine synthase reductase (MTRR) 66A>G and methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C...
  80. doi Vitamin B(12) and birth defects
    Fei Li
    Department of Human Genetics, McGill University, Que, Canada
    Mol Genet Metab 98:166-72. 2009
    ..cubilin, AMN, coding for amnionless, the MTR gene coding for methionine synthase, or MTRR coding for methionine synthase reductase, is embryonic lethal in mice...
  81. pmc Effects of nicorandil on the recovery of reflex potentials after spinal cord ischaemia in cats
    T Suzuki
    Department of Pharmacology, School of Medicine, Chiba University, Japan
    Br J Pharmacol 116:1815-20. 1995
    ..The monosynaptic (MSR) and polysynaptic reflex (PSR) potentials, elicited by electrical stimulation of the tibial nerve, were recorded ..
  82. pmc Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study
    S Farkas
    Department of Electrophysiology, Chemical Works of Gedeon Richter Ltd, Budapest, Hungary
    Br J Pharmacol 114:1193-205. 1995
    ..3. NBQX and GYKI 52466 were able to abolish completely the mono-, di- and polysynaptic ventral root reflexes (MSR, DSR, PSR) and the synaptic excitability of motoneurones, while hardly influencing direct excitability of ..
  83. doi Inducible clindamycin resistance in Staphylococcus aureus: a study from North India
    V Gupta
    Department of Microbiology, Government Medical College Hospital, Chandigarh, India
    J Postgrad Med 55:176-9. 2009
    ..The resistance to macrolide can be mediated by msr A gene coding for efflux mechanism or via erm gene encoding for enzymes that confer inducible or constitutive ..
  84. pmc Comparative genome analysis of four magnetotactic bacteria reveals a complex set of group-specific genes implicated in magnetosome biomineralization and function
    Michael Richter
    Microbial Genomics Group, Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    J Bacteriol 189:4899-910. 2007
    ..magnetotactic Alphaproteobacteria including the nearly complete genome of Magnetospirillum gryphiswaldense strain MSR-1, the complete genome of Magnetospirillum magneticum strain AMB-1, the complete genome of the magnetic coccus MC-1,..
  85. pmc Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae
    Shuqing Zhao
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Antimicrob Agents Chemother 53:3744-51. 2009
    ....
  86. pmc Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci
    Olivier Chesneau
    Unité des Staphylocoques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 49:973-80. 2005
    The Vga and Msr resistance determinants, encoded by mobile genetic elements in various staphylococcal strains, belong to a family of ATP-binding cassette (ABC) proteins whose functions and structures are ill defined...
  87. ncbi Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals
    Kiyoshi Takahashi
    Fuji Bio Co Ltd, 1 14 23 Kasuga, Kumamoto 860 0047, Japan
    Med Electron Microsc 35:179-203. 2002
    ..Among various scavenger receptors, class A type I and type II macrophage scavenger receptors (MSR-A I,II) play the most important role in the uptake of oxidized low-density lipoprotein by macrophages...
  88. ncbi Corticotropin-releasing hormone and pro-opiomelanocortin gene expression in female monkeys with differences in sensitivity to stress
    Maria Luisa Centeno
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 86:277-88. 2007
    ..assessed in brain tissue collected from nonstressed female cynomolgus monkeys previously categorized as highly stress resilient (HSR), medium stress resilient (MSR), or stress sensitive (SS) with respect to stress-induced anovulation.
  89. ncbi Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype
    Masatoshi Tanaka
    Department of Urology, School of Medicine, Fukuoka University, Jonan ku, Japan
    Int J Antimicrob Agents 27:20-6. 2006
    ..gonorrhoeae strain with reduced susceptibility to ceftriaxone, which also showed a multidrug-resistant phenotype that can be explained by the presence of multiple loci mutations associated with antibiotic resistance...
  90. doi A thiol-activated lipase from Trichosporon asahii MSR 54: detergent compatibility and presoak formulation for oil removal from soiled cloth at ambient temperature
    S Suresh Kumar
    Department of Microbiology, University of Delhi, South Campus, New Delhi, 110021, India
    J Ind Microbiol Biotechnol 36:427-32. 2009
    An alkaline lipase from Trichosporon asahii MSR 54 was used to develop presoak formulation for removing oil stains at ambient temperature...
  91. ncbi Solubilization of nitrotoluenes in micellar nonionic surfactant solutions
    Dianne J Luning Prak
    US Naval Academy, 572M Holloway Road, Annapolis, MD 21402, USA
    Chemosphere 68:1961-7. 2007
    ..two or less in 10 g l(-1) surfactant solutions, but did not significantly change their molar solubilization ratios (MSR, e.g. 0.02 for TNT) or their micelle-water partition coefficients (K(m), e.g. 3.4 for TNT)...
  92. ncbi In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes
    G Novotna
    Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czechia
    Folia Microbiol (Praha) 52:593-9. 2007
    ..13 isolates with constitutive erm genes) or demonstrated telithromycin D-shaped zone (60 isolates with inducible msr(A) and/or erm)...
  93. pmc Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA
    Robert Lindberg
    Department of Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Antimicrob Agents Chemother 51:2117-22. 2007
    ..In conclusion, an unambiguous association between penA mosaic alleles, in conjunction with genetic polymorphisms in mtrR, porB1b, and ponA, and greater reduced susceptibility to cefixime and ceftriaxone was identified...
  94. ncbi Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin
    U K Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:25785-91. 1999
    We have studied insulin-dependent regulation of macrophage alpha(2)-macroglobulin signaling receptors (alpha(2)MSR) and low density lipoprotein receptor-related protein/alpha(2)M receptors (LRP/alpha(2)MR) employing cell binding of (125)..
  95. ncbi Enhancement of spinal monosynaptic reflexes with phenylethylamine and related drugs through descending noradrenergic neurons
    Y Hasebe
    Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    J Pharmacobiodyn 12:241-5. 1989
    ..such as methamphetamine, phenelzine, methylphenidate, nomifensine and mazindol on the spinal monosynaptic reflex (MSR) were investigated in rats treated with 6-hydroxydopamine (6-OHDA) or 5,6-dihydroxytryptamine (5,6-DHT)...
  96. ncbi Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1
    S J De Kimpe
    The William Harvey Research Institute, St Bartholomew s Hospital, Medical College, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Mol Pharmacol 53:1076-82. 1998
    The uptake of modified low density lipoprotein via the macrophage scavenger receptor (MSR) results in the formation of lipid-laden foam cells during atherosclerosis...
  97. ncbi Modulation of the mtrCDE-encoded efflux pump gene complex of Neisseria meningitidis due to a Correia element insertion sequence
    Corinne E Rouquette-Loughlin
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Microbiol 54:731-41. 2004
    ..We conclude that the mtr efflux system in meningococci is subject to transcriptional regulation by IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element...
  98. ncbi Postural reflexes, balance control, and functional mobility with long-duration head-down bed rest
    Millard F Reschke
    Neurosciences Laboratories, Human Adaptation and Countermeasures Division, NASA Johnson Space Center, Mail Code SK272, 2101 NASA Parkway, Houston, TX 77058, USA
    Aviat Space Environ Med 80:A45-54. 2009
    ..To differentiate somatosensory changes from graviceptor changes in post-spaceflight sensorimotor behavior, bed rest may serve as an exclusionary analog to spaceflight...
  99. pmc Simple, rapid, and inexpensive detection of Neisseria gonorrhoeae resistance mechanisms using heat-denatured isolates and SYBR green-based real-time PCR
    Gayle Kugelman
    Queensland Children s Medical Research Institute, Infectious Diseases Laboratory, Royal Children s Hospital, Herston Road, Herston, QLD 4029, Queensland Australia
    Antimicrob Agents Chemother 53:4211-6. 2009
    ..These methods may have broader application in the detection of polymorphisms associated with phenotypes of interest...
  100. ncbi Absence of linear correlation between fluctuations in area of simultaneous recorded monosynaptic responses and Hoffmann's reflexes in the rat
    Celia Reyes
    INR, SSA, Mexico
    Neurosci Lett 411:249-53. 2007
    In this study we analyze the possible relationship between fluctuations in area of monosynaptic reflex responses (MSR) and Hoffmann's reflex (H reflexes) in the plantar closed loop pathway of the anesthetized rat...
  101. pmc Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord
    Wendy Bautista
    Departamento de Fisiologia, Biofisica y Neurociencias, CINVESTAV IPN, Avenida IPN No 2508, Colonia Zacatenco, Mexico D F, CP 07300, Mexico
    J Physiol 588:2621-31. 2010
    ..to determine if GABA(A) receptors mediating tonic inhibition participate in the modulation of monosynaptic reflex (MSR) in the vertebrate spinal cord...

Research Grants46

  1. GENETIC RISK FACTORS FOR HYPERHOMOCYSTEINEMIA
    ROY GRAVEL; Fiscal Year: 2006
    ..A major outcome was the discovery of a novel enzyme methionine synthase reductase (gene and enzyme symbol, MTRR) required for the activation of cobalamin-dependent methionine synthase (..
  2. Conversion of Inactive Cobalamins to Coenzyme B12
    Thomas Bobik; Fiscal Year: 2005
    ..Preliminary studies showed that the human methionine synthase reductase can reduce cob(II)alamin to cob(I)alamin for coenzyme B 12 synthesis, and results indicated a highly ..
  3. Pharmacogenetics of Methotrexate Therapy in Arthritis
    ALEXANDER WHITEHEAD; Fiscal Year: 2006
    ..In addition, methionine synthase (MTR), cystathionine Beta-synthase (CBS), and methionine synthase reductase (MTRR) are involved in reactions that control Hcy concentrations...
  4. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..SHMT1), mehylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), thymidylate synthase (TYMS or TS), S-adenosylhomocysteine hydrolase (AHCY or SAHH), ADA (..
  5. Kinetic Analysis of Methionine Synthase Reductase
    KIRSTEN WOLTHERS; Fiscal Year: 2004
    ..of the proposed research are to understand the enzymology of human methionine synthase (MS) and methionine synthase reductase (MSR) as well as their clinically relevant variants...
  6. DYNAMIC AND KINETIC BEHAVIOR OF FOLATE METABOLISM
    Andrew Clifford; Fiscal Year: 2005
    ..folic acid in individuals with respect to two variants of MTHFR (C677T & A1298C), MS A2756G, and methionine synthase reductase (MTRR) A66G...
  7. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..24, and 44 weeks) and use QD-antibody conjugates injected in vivo to detect the inflammatory markers VCAM-1, MCP-1, MSR, and dimerized fibrin (D-dimer) on plaque surfaces, which serve as relatively early and late indicators of ..
  8. Ann E Jerse; Fiscal Year: 2014
    ..Finally, phosphorothiorate- modified antisense oligo-deoxynucleotides (PS-ODNs) that target the mtrC transcript will be tested as a potential therapy for increasing Gc susceptibility to APs, antibiotics, and PMN killing. ..
  9. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2009
    ..Finally, phosphorothiorate-modified antisense oligodeoxynucleotides (PS-ODNs) that target the mtrC transcript will be tested as a potential therapy for increasing Gc susceptibility to APs, antibiotics, and PMN killing. ..
  10. Significance of four methionine sulfoxide reductases in Staphylococcus aureus
    Vineet Kumar Singh; Fiscal Year: 2010
    ..The purpose of this study is to determine precise physiological roles of methionine sulfoxide reductase (Msr) enzymes in this organism. Oxidation of protein bound methionine residues leads to loss of biological activity...
  11. WILLIAM MAURICE SHAFER; Fiscal Year: 2016
    ..The information gained will help in the development of new antimicrobials to treat or prevent gonorrhea, which remains a worldwide public health problem. ..
  12. JOSEPH THOMAS WADE; Fiscal Year: 2016
    ..We will apply genomics and high throughput technologies to develop a Mycobacterial Systems Resource (MSR) that will dramatically accelerate research throughout the entire mycobacterial community...
  13. High Throughput Assay for Activators and Inhibitors of MSRA
    Herbert Weissbach; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The methionine sulfoxide reductase (Msr) system has been shown to play an important role in protecting cells against oxidative damage...
  14. Molecular mechanisms of oxidative stress resistance in an animal model of aging w
    Sarah Milton; Fiscal Year: 2009
    ..residues on proteins and free amino acids;oxidized methionine compromises the activity of a number of enzymes and Msr may thus restore biological activity to damaged proteins...
  15. Amino Acid Repair Activity in Helicobacter pylori
    Robert J Maier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methionine sulfoxide reductases (Msr's) catalyze the reduction of methionine sulfoxide back to (normal) methionine...
  16. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..
  17. Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    Neil Kaplowitz; Fiscal Year: 2009
    ..An unexplored aspect of mitochondrial homeostasis is the mitochondrial stress response (MSR) which regulates matrix chaperone production (e.g...
  18. CLONING OF PNEUMOCYSTIS CARINII CHROMOSOME ENDS
    Melanie Cushion; Fiscal Year: 2002
    ..carinii organisms. A third gene family, encoding the major surface glycoproteins related antigens (MSR), has also been identified in the subtelomeric regions...
  19. GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINS
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  20. Role of Msr in Oxidative Stres in S. aureus
    RADHESHYAM JAYASWAL; Fiscal Year: 2002
    ..The results of the proposed studies are expected to provide detailed understanding of the MsrA in staphylococcal physiology and pathogenesis. ..
  21. SQUID-Controlled Noise Reduction Coils for Fetal MCG
    DOUGLAS PAULSON; Fiscal Year: 2003
    ..We propose to replace the MSR for fMCG with a system combining two commercially developed components: active cancellation and reference SQUiDs...
  22. Folate Deficiency, Metabolism & Sporadic Retinoblastoma
    Manuela Orjuela; Fiscal Year: 2006
    ..If our results are as anticipated, this project may lead to the development of new preventive strategies for those populations with an elevated incidence of sporadic retinoblastoma. ..
  23. STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENES
    James Stringer; Fiscal Year: 2009
    ..murina. In this application, we propose structural and functional studies on gene families (MSG, PRT, MSR) in rodent Pneumocystis species...
  24. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005
    ..and its receptor CCR1 in macrophage recruitment and suggest that the class A macrophage scavenger receptor (MSR-A) is involved in the clearance of apoptotic neurons, thus linking apoptosis, phagocytosis, cell proliferation, and ..
  25. Genetic Profiles for Perioperative Applications
    ROBERT KWIATKOWSKI; Fiscal Year: 2001
    ..abstract_text> ..
  26. A novel method to identify methionine-oxidized proteins
    Jackob Moskovitz; Fiscal Year: 2008
    ..events that may cause permanent protein damage if not properly reversed by the methionine sulfoxide reductase (Msr) system (consisting of MsrA and MsrB enzymes)...
  27. Molecular Epidemiology of Colorectal Adenomas
    Robert Haile; Fiscal Year: 2005
    ..Thomas and Cortessis, we will apply this method to data generated by this study. ..
  28. Gene-nutrient Etiologies of Neural Tube Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  29. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2002
    ..abstract_text> ..
  30. MOLECULAR GERONTOLOGY OF THE HUMAN OLFACTORY SYSTEM
    MARILYN GETCHELL; Fiscal Year: 2002
    ..abstract_text> ..
  31. 14th International Congress on Flavins and Flavoproteins
    ROWENA MATTHEWS; Fiscal Year: 2002
    ..Tea will be served at each poster session. Presentations were selected by an International Organizing Committee with an eye to a diverse representation of speakers at the meeting. ..
  32. Folate Polymorphisms, Dietary Folate and Prostate Cancer
    Victoria Stevens; Fiscal Year: 2005
    ..The results of this study are expected to indicate the importance of folate for prostate cancer and whether changing folate consumption can modify the risk associated with genetic variants in the pathway for folate metabolism. ..
  33. Mechanistic model of multisensory postural control
    John Jeka; Fiscal Year: 2005
    ..Future work will address patient populations with similar techniques to determine the basis of their balance deficits. ..
  34. MULTISENSORY INTEGRATION AND HUMAN POSTURAL CONTROL
    JOHN JOSEPH JEKA; Fiscal Year: 2010
    ..4 B and are expected to exceed $32B by 2020, leading Congress to institute legislation expanding fall-related research and fall-risk reduction programs (House Resolution 3695, 2002). ..
  35. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  36. Gene and Nutrient Etiologies of Human Heart Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  37. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  38. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..677C yields T and 1298A yields C polymorphisms in 5,10- methylenetetrahydrofolate Reductase (MTHFR), methionine synthase reductase (MTRR) 66A yields G polymorphism, betaine-homocysteine methyltransferase (BHMT) mutation and ..
  39. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  40. 2008 Bioanalytical Sensors Gordon Research Conference
    Chris Taitt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. MULTISENSORY INTEGRATION AND HUMAN POSTURAL CONTROL
    John Jeka; Fiscal Year: 2007
    ..abstract_text> ..
  42. REGULATION OF FOLATE METABOLISM
    ROWENA MATTHEWS; Fiscal Year: 2008
    ..We predict that phosphorylation will play an important role in modulating the flux of one-carbon units. ..
  43. 17th Meeting of the International Society for Posture and Gait Research, July 14
    John Jeka; Fiscal Year: 2007
    ..We argue that a better understanding of the processes underlying the control of posture and locomotion will enhance the treatment options presently available. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  45. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. [unreadable] [unreadable]..
  46. Enhanced Killing of Cancer Cell by Sulindac and Oxidative Stress
    Herbert Weissbach; Fiscal Year: 2007
    ..We will contribute the understanding of the mechanism that lead to cancer cells death by the NSAID Sulindac and its derivatives. PHS 398/2590 (Rev. 09/04) Page Continuation Format Page [unreadable] [unreadable] [unreadable]..