MEGF8

Summary

Gene Symbol: MEGF8
Description: multiple EGF like domains 8
Alias: C19orf49, CRPT2, EGFL4, SBP1, multiple epidermal growth factor-like domains protein 8, EGF-like domain-containing protein 4, EGF-like-domain, multiple 4, HBV pre-S2-binding protein 1, HBV pre-s2 binding protein 1, epidermal growth factor-like protein 4, hepatitis B virus pre-S2-binding protein 1
Species: human

Top Publications

  1. pmc Identification of SFBB-containing canonical and noncanonical SCF complexes in pollen of apple (Malus × domestica)
    Mai F Minamikawa
    Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan
    PLoS ONE 9:e97642. 2014
  2. doi Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression
    Jianzhuang Gong
    Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University
    Tohoku J Exp Med 239:279-85. 2016
  3. pmc Loss of Selenium-Binding Protein 1 Decreases Sensitivity to Clastogens and Intracellular Selenium Content in HeLa Cells
    Changhui Zhao
    Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin Province, 130062, China
    PLoS ONE 11:e0158650. 2016
  4. doi Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiles in sprague-dawley male rats
    Yu Kyung Lee
    a College of Pharmacy, Pusan National University, Busan, Republic of Korea
    J Toxicol Environ Health A 77:1384-98. 2014
  5. doi Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: a novel mechanism of cancer-specific cytotoxicity of selenite
    Yulei Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei, 430071, China
    Free Radic Biol Med 79:186-96. 2015
  6. ncbi Selenium Binding Protein 1 autoantibodies in ovarian disorders and ovarian cancer
    Yi Yu-Rice
    Y Yu Rice, Pharmacology, Rush University Medical Center, Chicago, United States
    Reproduction . 2016
  7. pmc MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons
    Caitlin Engelhard
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States
    elife 2:e01160. 2013
  8. pmc Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes
    Chongxu Zhang
    Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, 03824
    Protein Sci 23:1036-49. 2014
  9. pmc Targeted discovery and validation of plasma biomarkers of Parkinson's disease
    Catherine Pan
    Department of Pathology, University of Washington School of Medicine, 325 9th Avenue, HMC 359635, Seattle, Washington 98104, United States
    J Proteome Res 13:4535-45. 2014
  10. doi Effect of weight loss on central systolic blood pressure in elderly community-dwelling persons
    Ryuichi Kawamoto
    1 Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan 2 Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, Japan
    Hypertens Res 37:933-8. 2014

Research Grants

  1. Clyde L Denis; Fiscal Year: 2016
  2. Christopher J Ward; Fiscal Year: 2015
  3. Role of Glutathione Peroxidase in Chemoprotection
    Alan Diamond; Fiscal Year: 2002
  4. Selenium, Aminothiols, and Radiation
    Alan Diamond; Fiscal Year: 2004
  5. Selenoproteins and Prostate Cancer
    Alan Diamond; Fiscal Year: 2007

Scientific Experts

  • Qi Ying
  • Andry Rico Razakamanantsoa
  • B Cooke
  • C S Giometti
  • K Kohara
  • J Krushkal
  • A M Diamond
  • Tara Smith
  • Jill C Preston
  • Tianhong Li
  • Clyde L Denis
  • Wancai Yang
  • Christopher J Ward
  • Emmanuel Ansong
  • Wenfeng Fang
  • Jin Zhang
  • Veronique Hugouvieux
  • Dede N Ekoue
  • Xin Wang
  • Jacques Bourguignon
  • Agnès Jourdain
  • Nicole M Pohl
  • Christelle Dutilleul
  • Jianzhuang Gong
  • Changhui Zhao
  • Amuza Byaruhanga Lucky
  • Mariana De Niz
  • Jo Anne Chan
  • Xing Tan
  • Eui Kyung Lee
  • Yi Yu-Rice
  • A E Rosca
  • Thomas M Laue
  • S P Zadorsky
  • Byung Mu Lee
  • Eun Young Park
  • Hyung Sik Kim
  • Lev M Kats
  • Wen Xi
  • Seung Jun Kwack
  • Taketo Otsuka
  • Yueh Chin Chiang
  • Ji Yeon Son
  • Yulei Wang
  • Guoan Chen
  • Mai F Minamikawa
  • Florie Schild
  • Catherine Pan
  • Chongxu Zhang
  • Ryuichi Kawamoto
  • Yu Kyung Lee
  • Caitlin Engelhard
  • Andrew P Norgan
  • Sarah F Mitchell
  • Chenjing Zhang
  • Karen Oliva
  • Christine Langer
  • Tobias Spielmann
  • Meipei She
  • Arlett Heiber
  • Roy Parker
  • Bin Xiong
  • Purusharth Rajyaguru
  • Susann Herrmann
  • Anita Jerome-Morais
  • Cheng Huang
  • Mari Odaira
  • Camilla Lööv
  • Stephen R F Twigg
  • Wei Guo Dong
  • Shulin Ju
  • Rukhsana Sultana
  • Amy L Silvers
  • David J Katzmann
  • Chang Tong
  • Xiuli Bi
  • Silvia Haase
  • Zhen Zhang
  • Christopher B Lee
  • W Douglas Fairlie
  • David G Beer
  • Mark B Orringer
  • Dafydd G Thomas
  • Thomas J Giordano
  • Bastien Llamas
  • Zhihua Hua
  • Ishara Azmi
  • Hideaki Fujita
  • Marcelo G Bonini
  • Michael A Warso

Detail Information

Publications70

  1. pmc Identification of SFBB-containing canonical and noncanonical SCF complexes in pollen of apple (Malus × domestica)
    Mai F Minamikawa
    Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan
    PLoS ONE 9:e97642. 2014
    ..protein forms an E3 ligase complex, SCF complex with Skp1, Cullin1 (CUL1) and Rbx1, however, in Petunia inflata, SBP1 (S-RNase binding protein1) was reported to play the role of Skp1 and Rbx1, and form an SCFSLF-like complex for ..
  2. doi Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression
    Jianzhuang Gong
    Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University
    Tohoku J Exp Med 239:279-85. 2016
    ..Selenium-binding protein 1 (SBP1) has been shown as a possible mediator of selenium's anti-cancer functions...
  3. pmc Loss of Selenium-Binding Protein 1 Decreases Sensitivity to Clastogens and Intracellular Selenium Content in HeLa Cells
    Changhui Zhao
    Department of Food Quality and Safety, College of Food Science and Engineering, Jilin University, Changchun, Jilin Province, 130062, China
    PLoS ONE 11:e0158650. 2016
    Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. Loss of SBP1 during carcinogenesis usually predicts poor prognosis...
  4. doi Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiles in sprague-dawley male rats
    Yu Kyung Lee
    a College of Pharmacy, Pusan National University, Busan, Republic of Korea
    J Toxicol Environ Health A 77:1384-98. 2014
    ..monocyte chemoattractant protein-1 (MCP-1), kidney injury molecules-1 (Kim-1), and selenium-binding protein 1 (SBP1) in rat urine...
  5. doi Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: a novel mechanism of cancer-specific cytotoxicity of selenite
    Yulei Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei, 430071, China
    Free Radic Biol Med 79:186-96. 2015
    ..investigate the roles of two distinct representatives of selenium-containing proteins, selenium-binding protein 1 (SBP1) and glutathione peroxidase 1 (GPX1), in selenite-mediated cancer-specific cytotoxicity...
  6. ncbi Selenium Binding Protein 1 autoantibodies in ovarian disorders and ovarian cancer
    Yi Yu-Rice
    Y Yu Rice, Pharmacology, Rush University Medical Center, Chicago, United States
    Reproduction . 2016
    ..The goal was to determine if antibodies to Selenium Binding Protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and ..
  7. pmc MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons
    Caitlin Engelhard
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States
    elife 2:e01160. 2013
    ..Using a three-generation forward genetic screen in mice we have identified Megf8 as a novel modifier of BMP4 signaling in trigeminal ganglion (TG) neurons...
  8. pmc Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes
    Chongxu Zhang
    Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, 03824
    Protein Sci 23:1036-49. 2014
    ..but found that only five of these proteins were present in the 77S translation complex: eRF1, SLF1, SSD1, PUB1, and SBP1. eRF1 is involved in translation termination, SBP1 is a translational repressor, and SLF1, SSD1, and PUB1 are known ..
  9. pmc Targeted discovery and validation of plasma biomarkers of Parkinson's disease
    Catherine Pan
    Department of Pathology, University of Washington School of Medicine, 325 9th Avenue, HMC 359635, Seattle, Washington 98104, United States
    J Proteome Res 13:4535-45. 2014
    ..A combination of four peptides (derived from PRNP, HSPG2, MEGF8, and NCAM1) provided an overall area under curve (AUC) of 0.753 (sensitivity: 90.4%; specificity: 50.0%)...
  10. doi Effect of weight loss on central systolic blood pressure in elderly community-dwelling persons
    Ryuichi Kawamoto
    1 Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan 2 Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, Japan
    Hypertens Res 37:933-8. 2014
    ..Before and at the end of the 12-week training program, metabolic variables, and first peak radial systolic BP (SBP1) and second peak radial SBP (SBP2) as estimates of central SBP, were obtained...
  11. pmc Biochemical and biophysical characterization of the selenium-binding and reducing site in Arabidopsis thaliana homologue to mammals selenium-binding protein 1
    Florie Schild
    From the Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire de Physiologie Cellulaire et Végétale, CEA, Université Grenoble Alpes, CNRS UMR5168, INRA USC1359
    J Biol Chem 289:31765-76. 2014
    The function of selenium-binding protein 1 (SBP1), present in almost all organisms, has not yet been established. In mammals, SBP1 is known to bind the essential element selenium but the binding site has not been identified...
  12. doi Chromosome VIII disomy influences the nonsense suppression efficiency and transition metal tolerance of the yeast Saccharomyces cerevisiae
    S P Zadorsky
    Department of Genetics and Biotechnology, St Petersburg State University, St Petersburg, Russian Federation
    Yeast 32:479-97. 2015
    ..This antisuppressor effect is not associated with decreased stop codon read-through. We identified SBP1, a gene that localizes to chromosome VIII, as a dosage-dependent antisuppressor that strongly contributes to the ..
  13. pmc Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells
    Lev M Kats
    Department of Microbiology, Monash University, Victoria 3800, Australia
    Biochim Biophys Acta 1848:1619-28. 2015
    ..We have previously shown that a resident MC protein, skeleton-binding protein 1 (SBP1), is essential for the placement of PfEMP1 onto the RBC surface and hypothesised that the function of SBP1 may be ..
  14. pmc Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways
    Qi Ying
    College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China Department of Pathology, Xinxiang Medical University, Xinxiang, 453003, China Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, United States of America
    PLoS ONE 10:e0126285. 2015
    Previous studies have shown the tumor-suppressive role of selenium-binding protein 1 (SBP1), but the underlying mechanisms are unclear...
  15. pmc Evidence that selenium binding protein 1 is a tumor suppressor in prostate cancer
    Emmanuel Ansong
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 10:e0127295. 2015
    Selenium-Binding Protein 1 (SBP1, SELENBP1, hSP56) is a selenium-associated protein shown to be at lower levels in tumors, and its lower levels are frequently predictive of a poor clinical outcome...
  16. pmc The subcellular location of selenoproteins and the impact on their function
    Alan M Diamond
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Nutrients 7:3938-48. 2015
    ..of these proteins have been described to reside in two or more cellular compartments, and in the case of GPx-1 and SBP1, interact with each other...
  17. pmc The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis
    Taketo Otsuka
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA
    Infect Immun 84:432-8. 2015
    ..catarrhalis. In this study, we showed that SBP1, -2, and -3 individually bind different basic amino acids with exquisite specificity...
  18. doi Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P)
    Dede N Ekoue
    Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA Electronic address
    J Trace Elem Med Biol 39:227-233. 2017
    ..proteins whose levels have been reported to be responsive to selenium availability, including GPX1, SELENOF and SBP1. There was an association between a polymorphism in the gene for MnSOD and the levels of the encoded protein...
  19. pmc Plasmodium knowlesi Skeleton-Binding Protein 1 Localizes to the 'Sinton and Mulligan' Stipplings in the Cytoplasm of Monkey and Human Erythrocytes
    Amuza Byaruhanga Lucky
    Department of Protozoology, Institute of Tropical Medicine NEKKEN, Nagasaki University, Sakamoto, Nagasaki 852 8523, Japan
    PLoS ONE 11:e0164272. 2016
    ..In this study, we analyzed SBP1 orthologs across the Plasmodium genus by BLAST analysis and conserved gene synteny, which were also recently ..
  20. ncbi Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity
    Eui Kyung Lee
    College of Pharmacy, Pusan National University, Busan, 609 735, Republic of Korea
    Arch Toxicol . 2016
    ..The corresponding spots were quantitated by RT-PCR. Selenium-binding protein 1 (SBP1) was found to be the most markedly upregulated protein in the kidney cortex of rats after HgCl2 ..
  21. pmc Isolated mammalian and Schizosaccharomyces pombe ran-binding domains rescue S. pombe sbp1 (RanBP1) genomic mutants
    I Novoa
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 10:2175-90. 1999
    ..RanBP1, sbp1p, and the RBD of each in mammalian cells, in wild-type fission yeast, and in yeast whose endogenous sbp1 gene was disrupted...
  22. pmc Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats
    A E Rosca
    Department of Physiology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Braz J Med Biol Res 49:e5116. 2016
    ..Systolic blood pressure (SBP) was measured at the beginning of the study (SBP1), 2 (SBP2) and 3 months (SBP3) later...
  23. pmc The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites
    Mariana De Niz
    Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland
    Nat Commun 7:11659. 2016
    ..Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P...
  24. pmc A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies
    Jo Anne Chan
    Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Melbourne, Vic, 3001, Australia
    Cell Mol Life Sci 73:4141-58. 2016
    ..Genetic deletion of the trafficking protein skeleton-binding protein-1 (SBP1), which is involved in trafficking the surface antigen PfEMP1, led to a dramatic reduction in antibody recognition ..
  25. doi Long term chemo-hydro-mechanical behavior of compacted soil bentonite polymer complex submitted to synthetic leachate
    Andry Rico Razakamanantsoa
    LUNAM University, IFSTTAR, GERS, GMG, F 44344 Bouguenais, France Electronic address
    Waste Manag 53:92-104. 2016
    ..conductivity of prehydrated soil bentonite (SB) and direct permeation of polymer added soil bentonite are studied (SBP1 and SBP2). Hydraulic test duration are in range of 45days to 556days long...
  26. pmc Downregulation of selenium-binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma
    Xing Tan
    School of Nursing, University of South China, 28 Changsheng Road West, Hengyang, 421001, Hunan, China
    World J Surg Oncol 14:70. 2016
    We found that selenium-binding protein 1 (SBP1) was progressively decreased in the human bronchial epithelial carcinogenic processes...
  27. pmc Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation
    Xin Wang
    Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, United States of America
    PLoS ONE 11:e0150616. 2016
    ..different abundances of the closed-loop factors eIF4E, eIF4G, and PAB1 and that of the translational repressor, SBP1. We establish that closed-loop factors eIF4E/eIF4G dissociated both as ribosomes transited polyadenylated mRNA from ..
  28. pmc A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1
    Qi Ying
    Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China
    Int J Mol Sci 16:27599-608. 2015
    The concentration of selenium-binding protein1 (SBP1) is often lower in tumors than in the corresponding tissue and lower levels have been associated with poor clinical outcomes...
  29. pmc Molecular cross-talk between members of distinct families of selenium containing proteins
    Emmanuel Ansong
    Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA
    Mol Nutr Food Res 58:117-23. 2014
    ..One of these, selenium-binding protein 1 (SBP1), is a protein of unknown function that has been shown to be reduced in tumors of diverse tissue types as compared ..
  30. doi Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1α to promote hepatocellular carcinoma invasiveness
    Cheng Huang
    Liver Cancer Institute, Fudan University, Shanghai, China
    Clin Cancer Res 18:3042-53. 2012
    We aimed to characterize the role of selenium-binding protein 1 (SBP1) in hepatocellular carcinoma (HCC) invasiveness and underlying clinical significance.
  31. pmc Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element
    Andrew P Norgan
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 288:26147-56. 2013
    ..The Vta1 carboxyl-terminal Vta1 SBP1 Lip5 (VSL) domain stimulates Vps4 function by facilitating oligomerization of Vps4 into its active state...
  32. doi 2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue
    Karen Oliva
    Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia
    J Endocrinol 218:165-78. 2013
    ..dehydrogenase B chain (LDHB), perilipin-1 (PLIN1), peroxiredoxin-6 (PRX6 (PRDX6)), selenium-binding protein 1 (SBP1) and vinculin (VINC (VCL))...
  33. doi Selenium-binding protein 1 may decrease gastric cellular proliferation and migration
    Chenjing Zhang
    Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, PR China
    Int J Oncol 42:1620-9. 2013
    It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression...
  34. pmc Global analysis of yeast mRNPs
    Sarah F Mitchell
    Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado, USA
    Nat Struct Mol Biol 20:127-33. 2013
    ..Cross-linking and immunoprecipitation (CLIP) analyses of the P-body components Pat1, Lsm1, Dhh1 and Sbp1 identified sites of interaction on specific mRNAs, revealing positional binding preferences and co-assembly ..
  35. pmc Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization
    Stephen R F Twigg
    Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Am J Hum Genet 91:897-905. 2012
    ..Here, we describe a disorder caused by mutations in multiple epidermal-growth-factor-like-domains 8 (MEGF8), which exhibits substantial clinical overlap with Carpenter syndrome but is frequently associated with abnormal ..
  36. ncbi Strength of relationships of the pulse wave velocity and central hemodynamic indices with the serum N-terminal fragment B-type natriuretic peptide levels in men: a worksite cohort study
    Mari Odaira
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Circ J 76:1928-33. 2012
    ..The present cross-sectional study was conducted to examine the strength of the relationships of the arterial stiffness and central hemodynamic indices with the serum N-terminal fragment B-type natriuretic peptide (NT-pro BNP) levels...
  37. ncbi Genetic determinants of systolic and pulse pressure in an intercross between normotensive inbred rats
    Bastien Llamas
    Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada H2W 1R7
    Hypertension 48:921-6. 2006
    ..Only suggestive quantitative trait loci were found for systolic blood pressure, but the strongest one (Sbp1) had the same peak and linkage probability profile as Pp1...
  38. ncbi Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
    ..The protein expression status of human selenium-binding protein 1 (SBP1) in human tumours and the exact function of this protein are not known...
  39. pmc Engulfing astrocytes protect neurons from contact-induced apoptosis following injury
    Camilla Lööv
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e33090. 2012
    ..qRT-PCR analysis showed that members of both ced pathways and Megf8 are expressed in the cell culture, indicating their possible involvement in astrocytic engulfment...
  40. pmc Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins
    Purusharth Rajyaguru
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Cell 45:244-54. 2012
    ..RGG domain-containing proteins in yeast copurify with eIF4E/G and we demonstrate that two such proteins, Npl3 and Sbp1, also directly bind eIF4G and repress translation in a manner dependent on their RGG motifs...
  41. pmc Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue
    Anita Jerome-Morais
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA
    Prostate 72:1006-12. 2012
    ..Se-containing proteins including members of the glutathione peroxidase (GPx) family and Selenium-Binding Protein 1 (SBP1) have been linked to either cancer risk or development...
  42. pmc The Arabidopsis putative selenium-binding protein family: expression study and characterization of SBP1 as a potential new player in cadmium detoxification processes
    Christelle Dutilleul
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, Commissariat à l Energie Atomique CNRS Université Joseph Fourier INRA, 38054 Grenoble Cedex 9, France
    Plant Physiol 147:239-51. 2008
    ..Arabidopsis thaliana), the putative selenium-binding protein (SBP) gene family is composed of three members (SBP1-SBP3). Reverse transcription-polymerase chain reaction analyses showed that SBP1 expression was ubiquitous...
  43. pmc Herbicide safener-binding protein of maize. Purification, cloning, and expression of an encoding cDNA
    J S Scott-Craig
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 116:1083-9. 1998
    ..SafBP is most abundant in the coleoptile and scarcest in the leaves, consistent with the distribution of SafBA. SBP1, a cDNA encoding SafBP, was cloned using polymerase chain reaction primers based on purified proteolytic peptides...
  44. pmc Distribution of novel and previously investigated virulence genes in colonizing and invasive isolates of Streptococcus agalactiae
    T C Smith
    Department of Epidemiology, University of Iowa, Iowa City, IA 52242, USA
    Epidemiol Infect 135:1046-54. 2007
    ..III-3, were represented by 18 different genetic signatures and several serotypes, and that the presence of both sbp1 and rib was more predictive of invasive disease than spb1 alone...
  45. pmc Identification and characterization of components of a putative petunia S-locus F-box-containing E3 ligase complex involved in S-RNase-based self-incompatibility
    Zhihua Hua
    Intercollege Graduate Degree Program in Plant Biology, Pensylvania State University, University Park, Pensylvania 16802, USA
    Plant Cell 18:2531-53. 2006
    ..We also isolated a RING-HC protein, S-RNase Binding Protein1 (Pi SBP1), almost identical to Petunia hybrida SBP1, which interacts with Pi SLFs, S-RNases, Pi CUL1-G, and an E2 ubiquitin-..
  46. pmc A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells
    Brian M Cooke
    Molecular and Cellular Rheology Laboratory, Department of Microbiology, Monash University, Victoria 3800, Australia
    J Cell Biol 172:899-908. 2006
    ..Targeted gene disruption of a Maurer's cleft protein, SBP1 (skeleton-binding protein 1), prevented IRBC adhesion because of the loss of PfEMP1 expression on the IRBC surface...
  47. pmc Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1
    Ishara Azmi
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Biol 172:705-17. 2006
    ..Vta1 promotes proper assembly of Vps4 and stimulates its ATPase activity through the conserved Vta1/SBP1/LIP5 region present in Vta1 homologues across evolution, including human SBP1 and Arabidopsis thaliana LIP5...
  48. ncbi Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B
    Hideaki Fujita
    Division of Pharmaceutical Cell Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Cell Sci 117:2997-3009. 2004
    ..We have identified two SKD1-binding proteins, SBP1 and mVps2, by yeast two-hybrid screening and we assign them as mammalian class E Vps proteins...
  49. ncbi [Screening of the genes of hepatitis B virus PreS2 interacting proteins]
    Yin Ying Lu
    Gene Therapy Research Center, Institute of Infectious Diseases, 302nd Hospital of People s Liberation Army, Beijing 100039, China
    Zhonghua Gan Zang Bing Za Zhi 11:8-10. 2003
    ..To screen and clone the genes of proteins in hepatocytes interacting with hepatitis B virus (HBV) PreS2 by yeast-two hybridization technique...
  50. ncbi Evolutionary relationships among proteins encoded by the regulator of complement activation gene cluster
    J Krushkal
    Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609 2280, USA
    Mol Biol Evol 17:1718-30. 2000
    ..membrane cofactor protein (MCP), decay accelerating factor (DAF), and the sand bass proteins, the cofactor protein (SBP1) and its homolog, the cofactor-related protein (SBCRP-1)...
  51. ncbi Mouse liver selenium-binding protein decreased in abundance by peroxisome proliferators
    C S Giometti
    Biosciences Division, Argonne Laboratory, IL 60439, USA
    Electrophoresis 21:2162-9. 2000
    ..protein 2 (SBP2 formerly 56 kDa acetaminophen-binding protein, AP 56) and selenium-binding protein 1 (SBP1 formerly 56 kDa selenium-binding protein, SP 56) in mouse liver, proteins with a high degree of sequence similarity,..
  52. ncbi RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases
    A Frankel
    Department of Chemistry and Biochemistry and Molecular Biology Institute, UCLA, Los Angeles, California 90095 1569, USA
    Biochem Biophys Res Commun 259:391-400. 1999
    ..allowed us to tentatively identify the glycine- and arginine-rich (GAR) domain-containing proteins Gar1, Nop1, Sbp1, and Npl3 as major methyl-acceptors based on their known isoelectric points and apparent molecular weights...
  53. ncbi Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
    M Nakayama
    Kazusa DNA Research Institute, 1532 3 Yana, Kisarazu, 292 0812, Japan
    Genomics 51:27-34. 1998
    ....
  54. pmc The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein
    X He
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 148:645-56. 1998
    ..med1 encodes a homologue of the human Ran-binding protein, RanBP1, and has been renamed sbp1 (spi1-binding protein)...
  55. ncbi liguleless1 encodes a nuclear-localized protein required for induction of ligules and auricles during maize leaf organogenesis
    M A Moreno
    Yale University, Department of Biology, New Haven, Connecticut 06520 8104, USA
    Genes Dev 11:616-28. 1997
    ..the LG1 protein is largely novel but contains an internal domain of 77 amino acids with significant similarity to a domain present in two recently identified SQUAMOSA PROMOTER-BINDING proteins 1 and 2 (SBP1 and SBP2) in Antirhinum majus.
  56. doi Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer
    Tianhong Li
    Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA
    Mol Nutr Food Res 52:1289-99. 2008
    ..We identified approximately 3.5-fold significant downregulation of selenium-binding protein 1 (SBP1) in colorectal tumors compared to normal mucosa (p = 0.003)...
  57. pmc Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5
    W Douglas Fairlie
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 76:4332-44. 2008
    ..We used phage display to identify a small (14-residue) disulfide-bonded cyclic peptide (SBP1) that targets the enzyme domain of SERA5...
  58. doi Pollen proteins bind to the C-terminal domain of Nicotiana alata pistil arabinogalactan proteins
    Christopher B Lee
    Divisions of Biological Sciences, Interdisciplinary Plant Group, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 283:26965-73. 2008
    ..We found that an S-RNase-binding protein (SBP1), a C2 domain-containing protein (NaPCCP), and a putative cysteine protease bound to the AGP baits...
  59. doi Clinical usefulness of the second peak of radial systolic blood pressure for estimation of aortic systolic blood pressure
    K Kohara
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    J Hum Hypertens 23:538-45. 2009
    ..The radial waveform was analysed to obtain the first peak of radial SBP (SBP1), second peak of radial SBP (SBP2), radial augmentation index (AI) (radial (SBP2-DBP)/(SBP1-DBP) x 100 and aortic ..
  60. doi Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2
    Silvia Haase
    Bernhard Nocht Institute for Tropical Medicine, Malaria II, 20359 Hamburg, Germany
    Mol Microbiol 71:1003-17. 2009
    ..An N-terminal region and the transmembrane domain of the unrelated PEXEL-negative exported protein SBP1 (skeleton-binding protein 1) can functionally replace the corresponding regions in REX2, suggesting that these ..
  61. pmc Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy
    Zhen Zhang
    Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 106:3219-24. 2009
    ..region and a second causing replacement of a highly conserved cysteine with arginine (C193R) in the gene Megf8. Megf8 is evolutionarily conserved from human to fruit fly, and is observed to be ubiquitously expressed...
  62. pmc Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease
    Rukhsana Sultana
    Department of Chemistry, University of Kentucky, Lexington, KY, USA
    Antioxid Redox Signal 12:327-36. 2010
    ..CA II), heat shock protein 70 (Hsp70), mitogen-activated protein kinase I (MAPKI), and syntaxin binding protein I (SBP1) in MCI IPL...
  63. pmc Arabidopsis putative selenium-binding protein1 expression is tightly linked to cellular sulfur demand and can reduce sensitivity to stresses requiring glutathione for tolerance
    Veronique Hugouvieux
    Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, Commissariat à l Energie Atomique CNRS Université Joseph Fourier INRA, Institut de Recherches en Technologies et Sciences pour le Vivant, Commissariat a l Energie Atomique Grenoble, 38054 Grenoble Cedex 9, France
    Plant Physiol 151:768-81. 2009
    Selenium-Binding Protein1 (SBP1) gene expression was studied in Arabidopsis (Arabidopsis thaliana) seedlings challenged with several stresses, including cadmium (Cd), selenium {selenate [Se(VI)] and selenite [Se(IV)]}, copper (Cu), zinc (..
  64. pmc Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts
    Nicole M Pohl
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA
    PLoS ONE 4:e7774. 2009
    It has been shown that selenium-binding protein 1 (SBP1) is significantly downregulated in different human cancers. Its regulation and function have not yet been established.
  65. doi SQUAMOSA-PROMOTER BINDING PROTEIN 1 initiates flowering in Antirrhinum majus through the activation of meristem identity genes
    Jill C Preston
    Department of Ecology and Evolutionary Biology, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    Plant J 62:704-12. 2010
    ..In the distantly related core eudicot species Antirrhinum majus L., paralogous SBP-box proteins SBP1 and SBP2 have likewise been implicated in regulating the AP1 ortholog SQUAMOSA (SQUA)...
  66. pmc Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity
    Amy L Silvers
    Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2009-21. 2010
    ..Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal ..
  67. doi Reduced selenium-binding protein 1 is associated with poor survival rate in gastric carcinoma
    Jin Zhang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
    Med Oncol 28:481-7. 2011
    Human selenium-binding protein 1 (SBP1) is known to play a key role in the development and progression of many cancers. The role of SBP1 expression in gastric carcinoma (GC) is far from being fully established...
  68. doi Altered expression of selenium-binding protein 1 in gastric carcinoma and precursor lesions
    Jin Zhang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 9 Ziyang Road, 430060, Wuhan, Hubei Province, China
    Med Oncol 28:951-7. 2011
    Selenium-binding protein 1 (SBP1) has been shown to be greatly reduced in various human cancers...
  69. pmc Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein
    Wenfeng Fang
    Department of Pathology, University of Illinois at Chicago, 60612, USA
    Carcinogenesis 31:1360-6. 2010
    ..The interaction between these representatives of different classes of selenoproteins was investigated. Increasing SBP1 levels in either human colorectal or breast cancer cells by transfection of an expression construct resulted in the ..
  70. pmc A yeast model of FUS/TLS-dependent cytotoxicity
    Shulin Ju
    Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS Biol 9:e1001052. 2011
    ..over-expression library identified five yeast DNA/RNA binding proteins, encoded by the yeast genes ECM32, NAM8, SBP1, SKO1, and VHR1, that rescue the toxicity of human FUS/TLS without changing its expression level, cytoplasmic ..

Research Grants5

  1. Clyde L Denis; Fiscal Year: 2016
    ..Finally, the exact translational complexes bound by translational repressors, SBP1, SCD6, and NPL3, will be determined by AU-FDS using Flag-tagged versions of PAB1, eIF4E, and eRF1.
  2. Christopher J Ward; Fiscal Year: 2015
    ..a source of epitope tagged PKD-ELVs to follow the interaction and Fc-chimeras containing domains derived from PC1, MEGF8, fibrocystin/polyductin and FAT4 to block the interaction...
  3. Role of Glutathione Peroxidase in Chemoprotection
    Alan Diamond; Fiscal Year: 2002
    ..These studies may result in the identification of individuals who are at risk of cancer as well as those that may benefit from selenium supplementation. ..
  4. Selenium, Aminothiols, and Radiation
    Alan Diamond; Fiscal Year: 2004
    ..Collectively, these studies will provide new insight on how selenium protects cells from radiation-induced mutagenesis and may lead to novel approaches to increase the beneficial properties of this nutrient. ..
  5. Selenoproteins and Prostate Cancer
    Alan Diamond; Fiscal Year: 2007
    ..Establishing a link between prostate cancer prevention, selenium and selenoprotein levels could lead to additional studies to maximize the protective effects of selenium and reduce prostate cancer incidence. ..