megalin

Summary

Gene Symbol: megalin
Description: LDL receptor related protein 2
Alias: DBS, GP330, low-density lipoprotein receptor-related protein 2, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, megalin
Species: human

Top Publications

  1. pmc The unfolding story of megalin (gp330): now recognized as a drug receptor
    M G Farquhar
    J Clin Invest 96:1184. 1995
  2. ncbi Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro
    M Z Kounnas
    American Red Cross, Biochemistry Department, Rockville, Maryland 20855
    J Biol Chem 268:14176-81. 1993
  3. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
  4. pmc Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
  5. ncbi Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein
    S Lundgren
    Department of Cell Research, Swedish University of Agricultural Science, Uppsala, Sweden
    J Histochem Cytochem 45:383-92. 1997
  6. ncbi Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide
    S M Hammad
    Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 272:18644-9. 1997
  7. ncbi Megalin is an endocytic receptor for insulin
    R A Orlando
    Department of Pathology, University of California, San Diego, La Jolla 92093 0651, USA
    J Am Soc Nephrol 9:1759-66. 1998
  8. ncbi Megalin and cubilin: multifunctional endocytic receptors
    Erik Ilsø Christensen
    Department of Cell Biology, University of Aarhus, University Park, Building 234, DK 8000 Aarhus C
    Nat Rev Mol Cell Biol 3:256-66. 2002
  9. ncbi Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis
    Akihiko Saito
    Department of Applied Molecular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Nephrology (Carlton) 10:S26-31. 2005
  10. ncbi The role of megalin (LRP-2/Gp330) during development
    Carolyn E Fisher
    Centre for Inflammation Research, Queen s Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH 16 4JT, Scotland, UK
    Dev Biol 296:279-97. 2006

Research Grants

  1. JAIME A KAMINER; Fiscal Year: 2014
  2. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
  3. Miguel A L Nicolelis; Fiscal Year: 2014
  4. Michelle M McCarthy; Fiscal Year: 2016
  5. ROBERT STERLING TURNER; Fiscal Year: 2015
  6. Jerrold L Vitek; Fiscal Year: 2016
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
  8. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
  9. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
  10. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010

Detail Information

Publications285 found, 100 shown here

  1. pmc The unfolding story of megalin (gp330): now recognized as a drug receptor
    M G Farquhar
    J Clin Invest 96:1184. 1995
  2. ncbi Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro
    M Z Kounnas
    American Red Cross, Biochemistry Department, Rockville, Maryland 20855
    J Biol Chem 268:14176-81. 1993
    b>Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the low density lipoprotein receptor (LDLR) and the LDLR-related protein/alpha 2-macroglobulin receptor (LRP)...
  3. ncbi Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
    G Hjälm
    Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
    Eur J Biochem 239:132-7. 1996
    We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
  4. pmc Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
    gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
  5. ncbi Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein
    S Lundgren
    Department of Cell Research, Swedish University of Agricultural Science, Uppsala, Sweden
    J Histochem Cytochem 45:383-92. 1997
    ..riboprobes and monoclonal antibodies to characterize tissue distribution of the human 550-kD homologue to gp330/megalin, primarily identified in the rat kidney...
  6. ncbi Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide
    S M Hammad
    Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 272:18644-9. 1997
    ..We have previously demonstrated that the endocytic receptor low density lipoprotein receptor-related protein-2/megalin (LRP-2), which is expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and ..
  7. ncbi Megalin is an endocytic receptor for insulin
    R A Orlando
    Department of Pathology, University of California, San Diego, La Jolla 92093 0651, USA
    J Am Soc Nephrol 9:1759-66. 1998
    ..By immunoprecipitation it was demonstrated that this binding site is megalin, the large multiligand binding endocytic receptor that is abundantly expressed in clathrin-coated pits on the ..
  8. ncbi Megalin and cubilin: multifunctional endocytic receptors
    Erik Ilsø Christensen
    Department of Cell Biology, University of Aarhus, University Park, Building 234, DK 8000 Aarhus C
    Nat Rev Mol Cell Biol 3:256-66. 2002
    ..b>Megalin and cubilin are two structurally different endocytic receptors that interact to serve such functions...
  9. ncbi Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis
    Akihiko Saito
    Department of Applied Molecular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Nephrology (Carlton) 10:S26-31. 2005
    b>Megalin is an endocytic receptor on the apical membranes of proximal tubule cells (PTC) in the kidney, and is involved in the reabsorption and metabolism of various proteins that have been filtered by glomeruli...
  10. ncbi The role of megalin (LRP-2/Gp330) during development
    Carolyn E Fisher
    Centre for Inflammation Research, Queen s Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH 16 4JT, Scotland, UK
    Dev Biol 296:279-97. 2006
    b>Megalin (LRP-2/GP330), a member of the LDL receptor family, is an endocytic receptor expressed mainly in polarised epithelial cells...
  11. ncbi Genetic association of low-density lipoprotein receptor-related protein 2 (LRP2) with plasma lipid levels
    Akiko Mii
    Department of Internal Medicine, Divisions of Neurology, Nephrology, and Rheumatology, Nippon Medical School, Tokyo, Japan
    J Atheroscler Thromb 14:310-6. 2007
    ..We studied the association between the low density lipoprotein-related protein 2 gene (LRP2) and levels of plasma total cholesterol (T-Cho) and LDL-cholesterol (LDL-C) among 352 adults in Japan...
  12. doi A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population
    Li ling Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Clin Chim Acta 412:268-70. 2011
    LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD)...
  13. pmc A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
    K Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 16:949-59. 2011
    ..In conclusion, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN. These results point to intriguing genes that await further validation in independent cohorts for confirmatory roles in AN...
  14. ncbi Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor
    R Raychowdhury
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Science 244:1163-5. 1989
    ..of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced...
  15. doi A megalin polymorphism associated with promoter activity and Alzheimer's disease risk
    Teo Vargas
    Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010
    ..This observation suggests that many, perhaps most, cases of AD are caused by faulty clearance of Abeta. Megalin, which plays an important role in mediating Abeta clearance, is an attractive candidate gene for genetic ..
  16. ncbi gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex
    S Stefansson
    Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Cell Sci 108:2361-8. 1995
    b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
  17. ncbi The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
    M Z Kounnas
    Holland Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 267:21162-6. 1992
    ..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
  18. ncbi Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritis
    S P Makker
    Department of Pediatrics, University of California, Davis 95616
    J Immunol 151:6500-8. 1993
    Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
  19. ncbi Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)
    Claudius Luziga
    Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Mol Histol 38:65-77. 2007
    b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
  20. pmc Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    B V Zlokovic
    Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
    Proc Natl Acad Sci U S A 93:4229-34. 1996
    ..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
  21. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
    The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
  22. ncbi Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus
    J T Chun
    Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
    Exp Neurol 157:194-201. 1999
    Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
  23. pmc Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells
    M Lundstrom
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
    Am J Pathol 143:1423-35. 1993
    ..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
  24. doi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
    ....
  25. ncbi Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
    Michael S Okun
    Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 62:1250-5. 2005
    Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
  26. ncbi Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER
    D Biemesderfer
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
    Am J Physiol 264:F1011-20. 1993
    The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
  27. ncbi Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
    J Am Soc Nephrol 6:61-7. 1995
    The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
  28. pmc Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex
    R A Orlando
    Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 90:4082-6. 1993
    b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
  29. pmc Human cytomegalovirus: detection of congenital and perinatal infection in Argentina
    Angélica Lidia Distéfano
    Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
    BMC Pediatr 4:11. 2004
    ..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
  30. ncbi Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule
    S Le Panse
    Department of Cell Biology, University of Aarhus, Denmark
    Exp Nephrol 5:375-83. 1997
    ..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
  31. ncbi Dental fear and pain: effect on patient's perception of the dentist
    K H Kunzelmann
    Polyclinic for Dental Care and Parodontology, Erlangen, FRG
    Community Dent Oral Epidemiol 18:264-6. 1990
    A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
  32. ncbi Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains
    Maria Paz Marzolo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Traffic 4:273-88. 2003
    b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
  33. ncbi Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells
    M L Elkjaer
    Department of Cell Biology, University of Aarhus, Denmark
    Eur J Cell Biol 67:57-72. 1995
    ..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
  34. ncbi Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Brain 130:1608-25. 2007
    Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
  35. doi [Deep brain stimulation for treatment of dystonia and tremor]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
    Nervenarzt 81:680-7. 2010
    Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
  36. pmc Induction of Heymann nephritis with a gp330/megalin fusion protein
    R Raychowdhury
    Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 148:1613-23. 1996
    ..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
  37. doi Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scans
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
    J Neurosurg 113:1234-41. 2010
    The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
  38. ncbi Deep brain stimulation for dystonia in adults. Overview and developments
    Joachim K Krauss
    Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
    Stereotact Funct Neurosurg 78:168-82. 2002
    ..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
  39. doi Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid
    André Bento-Abreu
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    J Neurochem 111:49-60. 2009
    ..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
  40. pmc Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells
    Michael Gekle
    Physiologisches Institut, Wurzburg, Germany
    J Physiol 552:471-81. 2003
    ..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
  41. pmc Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection
    Suresh B Boppana
    UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
    JAMA 303:1375-82. 2010
    ..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
  42. ncbi Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis
    M Marino
    Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Clin Endocrinol Metab 84:2468-74. 1999
    b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
  43. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
  44. doi Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremor
    Takashi Morishita
    Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurosurg 112:491-6. 2010
    ..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
  45. pmc Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principle
    Young Min Shon
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 112:539-48. 2010
    ..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
  46. doi Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
  47. doi Deep brain stimulation for camptocormia in dystonia and Parkinson's disease
    Hans Holger Capelle
    Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
    J Neurol 258:96-103. 2011
    ..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
  48. ncbi Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritis
    Alfonso Tramontano
    Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 172:2367-73. 2004
    ..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
  49. ncbi [Deep brain stimulation for Parkinson's disease and dystonia]
    Fusako Yokochi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Brain Nerve 61:473-83. 2009
    Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
  50. doi Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsy
    Angelo Franzini
    Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Stereotact Funct Neurosurg 86:373-81. 2008
    ..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
  51. ncbi Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobics
    R Moore
    Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
    Community Dent Oral Epidemiol 19:347-51. 1991
    ..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
  52. ncbi Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes
    Richard A Wennberg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
    Clin Neurophysiol 114:1403-18. 2003
    To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
  53. ncbi Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silica
    Antonio R Cestari
    Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
    J Colloid Interface Sci 309:402-11. 2007
    ..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
  54. ncbi Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330
    J J Kanalas
    Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
    Arch Biochem Biophys 299:255-60. 1992
    Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
  55. doi The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditions
    E Coley
    Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Br J Neurosurg 23:179-83. 2009
    Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
  56. doi Deep brain stimulation for secondary dystonia: results in 8 patients
    P F Katsakiori
    Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
    Acta Neurochir (Wien) 151:473-8; discussion 478. 2009
    ..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
  57. pmc Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Res Notes 3:60. 2010
    ..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
  58. ncbi Interactions between deep brain stimulation and levodopa in Parkinson's disease
    J G Nutt
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 57:1835-42. 2001
    To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
  59. pmc Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming
    Michael S Okun
    Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
    J Neurol Neurosurg Psychiatry 78:310-4. 2007
    Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
  60. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  61. doi Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
  62. ncbi Thalamic deep brain stimulation: comparison between unilateral and bilateral placement
    W Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
    Arch Neurol 58:218-22. 2001
    Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
  63. ncbi Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation
    Raghunatha R Yammani
    Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002
    The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
  64. ncbi Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experience
    Micheal D Phillips
    Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiology 239:209-16. 2006
    ..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
  65. ncbi A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
  66. doi Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus
    Marek A Mirski
    Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
    Seizure 18:64-70. 2009
    ..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
  67. doi Long-term effects of pallidal deep brain stimulation in tardive dystonia
    D Gruber
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Neurology 73:53-8. 2009
    ..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
  68. doi Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian rats
    Hisanao Akita
    Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
    Brain Res 1306:159-67. 2010
    ..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
  69. doi A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohort
    Houtan A Taba
    Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
    J Neurosurg 113:1224-9. 2010
    In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
  70. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
  71. ncbi Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high-molecular-weight glycoprotein antigen common to the kidney and teratocarcinomas
    M Nakamoto
    Department of Biochemistry, Faculty of Medicine, Kagoshima University
    J Biochem 114:344-9. 1993
    ..Brushin was shown to be the mouse counterpart of rat Heymann nephritis antigen, called gp330. The association between HBP-44 and brushin was revealed not only by co-precipitation upon indirect ..
  72. ncbi Introduction to the programming of deep brain stimulators
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 17:S181-7. 2002
    The clinical success of deep brain stimulation (DBS) for treating Parkinson's disease, tremor, or dystonia critically depends on the quality of postoperative neurologic management...
  73. ncbi 300-Hz subthalamic oscillations in Parkinson's disease
    G Foffani
    Department of Neurological Sciences, Universita di Milano, IRCCS Ospedale Maggiore di Milano, Milano, Italy
    Brain 126:2153-63. 2003
    ..Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for complicated Parkinson's disease, but how DBS acts ..
  74. ncbi [Dried blood spot Vitamin A determination by high pressure liquid chromatography with electrochemical detection]
    P Houze
    Laboratoire de Biochimie A, Hopital Saint Louis, Paris
    Ann Biol Clin (Paris) 62:539-46. 2004
    ..Sample collection on Dried Blood Spot (DBS) is less invasive and safer. Sample storage is easier...
  75. ncbi Double electrodes simultaneous stimulation and implantation technique in deep brain stimulation
    Liu guan Bian
    Department of Neurosurgery, Ruijin Hospital, Shanghai Second Medical University, China
    Chin J Traumatol 8:253-6. 2005
    ..Nowadays, deep brain stimulation (DBS) confirms its efficacy in alleviating different forms of tremor, including posttraumatic tremor...
  76. ncbi Hepatitis B surface antigenaemia and alpha-foetoprotein detection from dried blood spots: applications to field-based studies and to clinical care in hepatitis B virus endemic areas
    M Mendy
    Medical Research Council Fajara, Banjul, The Gambia, West Africa
    J Viral Hepat 12:642-7. 2005
    ..available kits for detection of HBV surface antigen (HBsAg) and alpha-foetoprotein (AFP) in dried blood spots (DBS) collected on filter paper...
  77. ncbi Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease
    Irene Rozet
    Department of Anesthesiology, University of Washington, Seattle, Washington, USA
    Anesth Analg 103:1224-8. 2006
    ..the alpha-2 agonist dexmedetomidine (Dex) suggests that it may be an ideal sedative drug for deep brain stimulator (DBS) implantation...
  78. ncbi Extradural cortical stimulation for movement disorders
    S Canavero
    Turin Advanced Neuromodulation Group, Turin, Italy
    Acta Neurochir Suppl 97:223-32. 2007
    ..with low morbidity-mortality which can be applied to patients who are excluded from deep brain stimulation (DBS), led to the first attempt of MCS in Parkinson's disease (PD)...
  79. ncbi Characteristics and distribution of somatosensory evoked potentials in the subthalamic region
    Mayumi Kitagawa
    Department of Neurology, Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan
    J Neurosurg 107:548-54. 2007
    ..Determination of this distribution may help in the correct placement of deep brain stimulation (DBS) leads.
  80. ncbi Automated electronic tongue based on potentiometric sensors for the determination of a trinary anionic surfactant mixture
    Montserrat Cortina
    Sensors and Biosensors Group, Department of Chemistry, Autonomous University of Barcelona, Edifici Cn, 08193 Bellaterra, Spain
    J Pharm Biomed Anal 46:213-8. 2008
    ..Dodecylsulfate (DS(-)), dodecylbenzenesulfonate (DBS(-)) and alpha-alkene sulfonate (ALF(-)) formed the three-analyte study case resolved in this work...
  81. doi [Reversible hypogeusia during bilateral thalamic stimulation for essential tremor]
    J Roggendorf
    Klinik fur Neurologie, Johann Wolfgang Goethe Universitat, Schleusenweg 2 16, 60528, Frankfurt, Deutschland
    Nervenarzt 79:454-6. 2008
    Deep brain stimulation of ventral intermediate nucleus (VIM-DBS) has become an established therapy for severe essential tremor (ET)...
  82. doi Pallidal deep brain stimulation is effective, and improves quality of life in primary segmental and generalized dystonia
    I M Skogseid
    Department of Neurology, Division of Clinical Neuroscience, Rikshospitalet University Hospital HF, Oslo, Norway
    Acta Neurol Scand Suppl 188:51-5. 2008
    ..In widespread segmental or generalized dystonia efficient treatment options were lacking until the recent introduction of deep brain stimulation of the internal globus pallidus (pallidal DBS).
  83. pmc Are two leads always better than one: an emerging case for unilateral subthalamic deep brain stimulation in Parkinson's disease
    Jay L Alberts
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Exp Neurol 214:1-5. 2008
    Bilateral subthalamic (STN) deep brain stimulation (DBS) provides significant symptom relief for the majority of well-screened patients suffering with Parkinson's disease (PD)...
  84. pmc Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
    Yaeko Motoyoshi
    Department of Bioethics, Tokai University School of Medicine, Isehara City, Kanagawa, Japan
    Kidney Int 74:1262-9. 2008
    b>Megalin, a member of the LDL receptor family, is expressed on the apical membrane of proximal tubules and serves as an endocytic scavenger of filtered proteins and hence might contribute to the tubule injury as a consequence of ..
  85. pmc Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillations
    Kevin W McCairn
    Department of Neurobiology, University of Pittsburgh, 4047 BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:1941-60. 2009
    Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease...
  86. ncbi The mechanism of dead-in-bed syndrome and other sudden unexplained nocturnal deaths
    B Parekh
    Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
    Curr Diabetes Rev 5:210-5. 2009
    The mechanism of dead-in-bed syndrome (DBS), a rare but devastating condition that mainly affects young type 1 diabetes patients, remains mysterious. A new theory is proposed to explain this syndrome...
  87. pmc Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's disease
    Nuri Firat Ince
    Departments of Neurosurgery and Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Neurosurgery 67:390-7. 2010
    ..used surgical treatment for patients with Parkinson's disease is the implantation of deep brain stimulation (DBS) electrodes within the subthalamic nucleus...
  88. doi Deep brain stimulation in clinical trials and animal models of depression
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Eur J Neurosci 32:1109-17. 2010
    Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression...
  89. doi Gilles de la Tourette syndrome and deep brain stimulation
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 32:1128-34. 2010
    ..In severe GTS patients who are refractory to medication and other therapies, deep brain stimulation (DBS) is investigated. To date there have been some 50-55 patients who have received DBS in 19 centres worldwide...
  90. doi Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?
    Sonny K H Tan
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropharmacology 61:387-99. 2011
    ..These findings include evidence that clinical depression is a side effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN), a treatment option in advanced PD...
  91. doi Graphene oxide based Pt-TiO2 photocatalyst: ultrasound assisted synthesis, characterization and catalytic efficiency
    Bernaurdshaw Neppolian
    The School of Chemistry, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Ultrason Sonochem 19:9-15. 2012
    ..photocatalytic and sonophotocatalytic degradation of a commonly used anionic surfactant, dodecylbenzenesulfonate (DBS), in aqueous solution was carried out using Pt-GO-TiO2 nanoparticles in order to evaluate the photocatalytic ..
  92. pmc Model-based analysis and control of a network of basal ganglia spiking neurons in the normal and parkinsonian states
    Jianbo Liu
    Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48823, USA
    J Neural Eng 8:045002. 2011
    ..may provide plausible explanations for the mechanisms underlying the therapeutic effects of deep brain stimulation (DBS) in Parkinson's disease and pave the way towards a model-based, network level analysis and closed-loop control and ..
  93. pmc Deep brain stimulation induces rapidly reversible transcript changes in Parkinson's leucocytes
    Lilach Soreq
    Department of Medical Neurobiology Physiology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Mol Med 16:1496-507. 2012
    Subthalamic deep brain stimulation (DBS) reversibly modulates Parkinson's disease (PD) motor symptoms, providing an unusual opportunity to compare leucocyte transcripts in the same individuals before and after neurosurgery and 1 hr after ..
  94. doi Quantification of HIV-RNA from dried blood spots using the Siemens VERSANT® HIV-1 RNA (kPCR) assay
    Maria Franca Pirillo
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Antimicrob Chemother 66:2823-6. 2011
    ..We evaluated the performance of the VERSANT(®) HIV-1 RNA (kPCR) assay for the determination of HIV-1 viral load from dried blood spots (DBS). Assay sensitivity and correlation with plasma quantification values were assessed.
  95. doi Explaining clinical effects of deep brain stimulation through simplified target-specific modeling of the volume of activated tissue
    B Madler
    Division of Stereotaxy and MR Based Operative Techniques, Department of Neurosurgery, Bonn University Hospital, Bonn, Germany
    AJNR Am J Neuroradiol 33:1072-80. 2012
    Although progress has been made in understanding the optimal anatomic structures as target areas for DBS, little effort has been put into modeling and predicting electromagnetic field properties of activated DBS electrodes and ..
  96. doi Deep-brain stimulation for anorexia nervosa
    Hemmings Wu
    Laboratory of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, Leuven, Belgium
    World Neurosurg 80:S29.e1-10. 2013
    ..After decades of brain-lesioning procedures offered as a last resort, deep-brain stimulation (DBS) has come under investigation in the last few years as a treatment option for severe and refractory AN.
  97. doi The impact of brain shift in deep brain stimulation surgery: observation and obviation
    P J Slotty
    Neurochirurgische Klinik, Heinrich Heine Universitat Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 154:2063-8; discussion 2068. 2012
    The impact of brain shift on deep brain stimulation surgery is considerable. In DBS surgery, brain shift is mainly caused by CSF loss. CSF loss can be estimated by post-surgical intracranial air...
  98. doi Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and III
    Jessica de Ruijter
    Department of Pediatrics and Amsterdam Lysosome Centre Sphinx, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Mol Genet Metab 107:705-10. 2012
    ..and sensitive method to measure levels of dermatan and heparan sulfate derived disaccharides in dried blood spots (DBS) with HPLC-MS/MS, and show that this reliably separates MPS I, II and MPS III newborns from controls and ..
  99. pmc Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda
    Imke H Bartelink
    Department of Clinical Pharmacy, Drug Research Unit, University of California, San Francisco, CA, USA
    J Clin Pharmacol 54:121-32. 2014
    ..In 2011, 62/225 ante-partum/post-partum single dried blood spot samples DBS and 43 post-partum hair samples for LPV/r were derived from 116 women, 51/194 ante-/post-partum DBS and 53 post-..
  100. doi Parkin mutation and deep brain stimulation outcome
    Hee Jin Kim
    Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea
    J Clin Neurosci 21:107-10. 2014
    Patients with parkin mutations are expected to be good candidates for deep brain stimulation (DBS) because of an excellent levodopa response and frequent occurrence of levodopa-induced dyskinesia...
  101. doi Anti-anhedonic effect of deep brain stimulation of the prefrontal cortex and the dopaminergic reward system in a genetic rat model of depression: an intracranial self-stimulation paradigm study
    Ellis Rea
    International Graduate Program Medical Neurosciences, Charite University Hospital, Berlin, Germany
    Brain Stimul 7:21-8. 2014
    ..In recent years, deep brain stimulation (DBS) has evolved as a potential tool to modulate pathological neural activity; stimulation of the subgenual cingulate (..

Research Grants73

  1. JAIME A KAMINER; Fiscal Year: 2014
    ..Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) stimulation will be applied to 6-OHDA lesioned ..
  2. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
    ..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
  3. Miguel A L Nicolelis; Fiscal Year: 2014
    ..The electrical stimulation of subcortical areas of the brain (deep brain stimulation - DBS) is an effective alternative option, which is rather restricted due to its invasiveness and associated risks...
  4. Michelle M McCarthy; Fiscal Year: 2016
    ..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that ..
  5. ROBERT STERLING TURNER; Fiscal Year: 2015
    ..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing abnormalities in GPi ..
  6. Jerrold L Vitek; Fiscal Year: 2016
    ..Despite the widespread use of DBS, its mechanism of action remains unclear...
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
  8. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..Chronic high frequency deep brain stimulation (DBS) has recently emerged as a possible therapeutic option in refractory cases incapacitated by their tics...
  9. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy ..
  10. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010
    Electrical stimulation in deep brain structures (DBS) has developed into an effective treatment for advanced Parkinson's disease and essential tremor...
  11. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
  12. Jerrold L Vitek; Fiscal Year: 2016
    ..motor signs in Parkinson's disease (PD), and the improvement in motor function during deep brain stimulation (DBS)...
  13. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..of cortical activation on functional MRI (fMRI), that the cognitive and motor effects of deep brain stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the frontal lobe to ..
  14. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
  15. DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PD
    Robert Turner; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's ..
  16. Evaluation of MRI Safety for Deep Brain Stimulation
    Ali Rezai; Fiscal Year: 2004
    There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
  17. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
  18. Daniel K Leventhal; Fiscal Year: 2016
    ..electrophysiological experiments in human subjects, and have clinical duties in the Movement Disorders and DBS programs...
  19. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of medically refractory Parkinson's disease (PD)...
  20. Controlled Trial of DBS for OCD
    Benjamin D Greenberg; Fiscal Year: 2010
    ..Our three collaborative pilot studies suggest that deep brain stimulation (DBS) of the ventral anterior limb of internal capsule and adjacent ventral striatum (VC/VS) is effective in otherwise ..
  21. HARRISON CARROLL WALKER; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies, cell transplant strategies, and the delivery of gene-delivered growth factors ..
  22. Mechanism of Action of Deep Brain Stimulation
    Kendall H Lee; Fiscal Year: 2012
    ..neuroengineering and neurosurgery will help the applicant elucidate the mechanisms by which Deep Brain Stimulation (DBS) treats Parkinson's disease...
  23. Ethics of Control and Consent in Brain Stimulation for Parkinson Disease
    CYNTHIA M S KUBU; Fiscal Year: 2010
    ..the ethical challenges inherent in participants'considerations of control using Deep Brain Stimulation (DBS) for the treatment of Parkinson disease (PD) as a paradigm...
  24. JOEL SYNES PERLMUTTER; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) dramatically improves motor function and quality of life in PD yet may alter cognitive skills and mood (Progress Report)...
  25. Time Course of Subthalamic Deep Brain Stimulation
    Scott E Cooper; Fiscal Year: 2011
    ..research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD)...
  26. Brandon S Bentzley; Fiscal Year: 2015
    ..drug rewards is reversible in rats by lesioning subthalamic nucleus (STN) bilaterally or by deep brain stimulation (DBS) in STN, as is done for treatment of Parkinson's disease...
  27. Comparison of Unilateral and Bilateral Subthalamic Stimulation in Parkinson's
    Jay L Alberts; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is a surgical procedure that is effective in improving the cardinal motor signs of advanced Parkinson's disease (PD)...
  28. Rat Model of Brain Stimulation in Parkinsonian Condition
    Jing Yu Chang; Fiscal Year: 2005
    Deep brain stimulation (DBS) has been used in the clinic to treat Parkinson's disease (PD) during the past decade. The neuronal mechanisms underlying the therapeutic effects of DBS, however, are yet to be clarified...
  29. Effects of DBS on sensorimotor processes
    Jing Yu Chang; Fiscal Year: 2005
    ..Deep brain stimulation (DBS) of subthalamic nucleus (STN) has been used increasingly in the clinic to alleviate Parkinsonian syndromes (PS) ..
  30. The Neuroprotective Effects of HF STN-DBS
    Anne Engemann; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): High-frequency deep brain stimulation of the subthalamic nucleus (HF STN-DBS) is now the most frequently practiced surgical therapy for the treatment of Parkinson's disease (PD) with more than ..
  31. Cerebellar stimulation for the treatment of dystonia: preclinical studies
    Ellen J Hess; Fiscal Year: 2013
    ..Deep brain stimulation (DBS) of the internal globus pallidus is another treatment option...
  32. FMRI Study of the Effects of DBS in Primary Generalized Dystonia (K23)
    Benjamin L Walter; Fiscal Year: 2010
    ..Select centers around the world, including our own, are now using deep brain stimulation (DBS) to treat dystonia...
  33. Mechanisms of Pallidal Deep Brain Stimulation
    Matthew Johnson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the globus pallidus (GP) is an effective treatment for patients with advanced Parkinson's disease (PD)...
  34. Optical Coherence Domain Reflectometry in Brain Probes
    Ali Rezai; Fiscal Year: 2004
    ..Refined guidance would greatly enhance the effectiveness and safety of deep-brain stimulation (DBS) with implanted electrodes...
  35. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..The goal of the proposed studies is to develop two complementary animal models to advance deep brain stimulation (DBS) of the central thalamus (CT) as a therapeutic strategy for the treatment of acquired cognitive disabilities ..
  36. Andre Guelman Machado; Fiscal Year: 2014
    ..our results are promising and human translation is feasible given that the technology for deep brain stimulation (DBS) is already FDA approved for the treatment of movement disorders and has been proven safe in over 40,000 implants...
  37. Role of the midline thalamus in arousal, attention and cognition
    ROBERT PAUL VERTES; Fiscal Year: 2013
    ..Schiff and colleagues demonstrated the remarkable findings that deep brain stimulation (DBS) of the midline thalamus in MCS patients restored a range of motor and cognitive functions that had long been ..
  38. MATTHEW DOUGLAS JOHNSON; Fiscal Year: 2015
    ..motor symptoms are refractory to medication and significantly impair their daily living, deep brain stimulation (DBS) is considered to be the only therapeutic option...
  39. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2012
    ..system has generated significant interest recently because of clinical data showing that deep brain stimulation (DBS) of the centromedian/parafascicular (CM/PF) complex, the main sources of thalamic inputs to the striatum, ..
  40. David Eidelberg; Fiscal Year: 2014
    ..Finally, in Specific Aim 3, we seek to understand how deep brain stimulation (DBS) works in dystonia when it does work, and identify predictors of patient response...
  41. Deep Brain Stimulation Array for Neuromodulation
    Rio J Vetter; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep Brain Stimulation (DBS) devices - 'brain pacemakers'- have emerged as a revolutionary new approach to the treatment of neurological disorders...
  42. Temporal Patterns of Deep Brain Stimulation
    Warren M Grill; Fiscal Year: 2013
    Chronic high frequency electrical stimulation of the brain, called deep brain stimulation (DBS), has evolved from a highly experimental technique to a well-established therapy for the treatment of movement disorders including dystonia, ..
  43. Peter E Konrad; Fiscal Year: 2014
    ..However, DBS therapy is currently limited by an incomplete understanding of DBS mechanisms of action due to complexity of the ..
  44. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
  45. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Known as deep brain stimulation (DBS), it has been successfully used to treat various human brain disorders (e.g...
  46. Mary Bartlett Bunge; Fiscal Year: 2016
    ..to make the caudal interface more permissive to axon growth and clinically relevant deep brain stimulation (DBS) and genetic approaches to enhance the intrinsic growth potential of injured brainstem neurons...
  47. AMY WILLIS AMARA; Fiscal Year: 2016
    ..Sleep disorders are common, affecting 74-98% of PD patients (1, 5). Deep brain stimulation (DBS) of the sub thalamic nucleus (STN) effectively controls motor symptoms in advanced PD (6-8)...
  48. The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional Processing
    Joseph S Neimat; Fiscal Year: 2012
    ..Over the past decade, deep brain stimulation (DBS) has become an increasingly important tool in the treatment of movement disorders...
  49. Kendall H Lee; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is an effective neurosurgical approach for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, epilepsy, and ..
  50. Itzhak Fried; Fiscal Year: 2016
    ..in the New England Journal of Medicine showing dramatic spatial memory enhancement when deep brain stimulation (DBS) of the human entorhinal area was given during the learning phase [13]...
  51. Emad N Eskandar; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Intellectual Merit: Deep brain stimulation (DBS) is a highly promising therapy for Parkinson's disease (PD)...
  52. ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2015
    ..comparing and contrasting the effects of optogenetic manipulations to the effects of deep brain stimulation (DBS) will help illuminate the exact mechanism of action of DBS, which remains unclear...
  53. JOSEPH GIUFFRIDA; Fiscal Year: 2014
    ..include pharmaceutical interventions such as levodopa and surgical procedures such as deep brain stimulation (DBS). It is important to accurately quantify motor function and disability in PD to assess intervention efficacy...
  54. Neural Circuit Basis of Behavioral Susceptibility and Resilience to Social Defeat
    JESSICA JILLIAN WALSH; Fiscal Year: 2013
    ..Recent studies have shown Deep Brain Stimulation (DBS) to be robustly efficacious in treating MDD patients and thus research has focused on discovering the underlying ..
  55. Striatal Origin of Pathological Beta Oscillations in Parkinson's Disease
    Xue Han; Fiscal Year: 2013
    ..Newer therapies such as deep brain stimulation (DBS) highlight the fact that PD involves neural network pathology...
  56. Constantine G Lyketsos; Fiscal Year: 2016
    ..The urgent need for the development of novel, non-amyloid therapies, the efficacy of deep brain stimulation (DBS) in neuropsychiatric disorders (e.g...
  57. Apparatus for placing electrodes for deep-brain stimulation
    J Michael Fitzpatrick; Fiscal Year: 2012
    ..to explore the feasibility of a new device to guide the placement of electrodes for deep- brain stimulation (DBS)...
  58. Behavioral effects of deep brain stimulation in rats with chronic pain
    THOMAS JEFFREY MARTIN; Fiscal Year: 2013
    ..The objectives of this proposal are: (1) to examine novel brain regions in which deep brain stimulation (DBS) reverses mechanical allodynia in rats following spinal nerve ligation (SNL), and (2) to determine the brain ..
  59. Paul Larson; Fiscal Year: 2016
    ..By applying deep brain stimulation (DBS) to area LC of the caudate nucleus, pathological neural activity with perceptual consequences will either be ..
  60. ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2016
    ..The novel aspect of this aim is the method of neuronal inactivation. We will utilize deep brain stimulation (DBS), a technique increasingly used clinically for the treatment of neurological diseases that has recently been tested ..
  61. COLLIN M CHALLIS; Fiscal Year: 2014
    ..Additionally, deep brain stimulation (DBS) of the mPFC in both humans and animals produced an antidepressant-like effect...
  62. ZACHARY AARON RODD; Fiscal Year: 2014
    ..Recent human studies have indicated that a neurosurgical procedure, deep brain stimulation (DBS), is effective at reducing alcohol consumption in alcoholics with a co-morbid psychological treatment (e.g...
  63. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  64. Local field potentials in the basal ganglia
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..Studies in humans, using implanted deep brain stimulation (DBS) electrodes to record LFPs, have suggested that high-amplitude, low frequency oscillations develop in parkinsonism ..
  65. DEEP BRAIN STIMULATION FOR PARKINSONS DISEASE
    JERROLD VITEK; Fiscal Year: 2005
    The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
  66. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
  67. FMRI Evaluation of DBS in Parkinson's Disease
    MICHEAL PHILLIPS; Fiscal Year: 2009
    ..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
  68. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..we performed two large-scale studies to determine the feasibility of quantitating TRECs using dried blood spots (DBS) to detect SCID newborns...
  69. Trafficking of LRP and Megalin in Polarized Cells
    Guojun Bu; Fiscal Year: 2006
    DESCRIPTION (provided by applicant) Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large membrane glycoproteins that belong to the LDL receptor gene family...
  70. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
    ..of the very cost effective and accurate method for screening newborn infants using filter paper dried blood spots (DBS) can be applied to pediatric and adult populations to detect diseases before disability and severe symptoms develop,..
  71. SERUM PROTEIN BINDING THE HN AUTOANTIGEN
    JOHN KANALAS; Fiscal Year: 1993
    ..Although a glycoprotein isolated form the brush border (gp330) is generally recognized as the putative antigen of HN, it's normal function has yet to be determined...
  72. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
  73. Advanced Technology and Tools for DBS Programming for Speech Functionality
    Craig van Horne; Fiscal Year: 2009
    ..Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders...