Genomes and Genes
Gene Symbol: megalin
Description: LDL receptor related protein 2
Alias: DBS, GP330, low-density lipoprotein receptor-related protein 2, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, megalin
Publications285 found, 100 shown here
- The unfolding story of megalin (gp330): now recognized as a drug receptorM G Farquhar
J Clin Invest 96:1184. 1995
- Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitroM Z Kounnas
American Red Cross, Biochemistry Department, Rockville, Maryland 20855
J Biol Chem 268:14176-81. 1993b>Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the low density lipoprotein receptor (LDLR) and the LDLR-related protein/alpha 2-macroglobulin receptor (LRP)...
- Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling propertiesG Hjälm
Department of Bone Metabolism, Rhone Poulenc Rorer Central Research, Collegeville PA, USA
Eur J Biochem 239:132-7. 1996We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats...
- Defective forebrain development in mice lacking gp330/megalinT E Willnow
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
Proc Natl Acad Sci U S A 93:8460-4. 1996gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
- Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing proteinS Lundgren
Department of Cell Research, Swedish University of Agricultural Science, Uppsala, Sweden
J Histochem Cytochem 45:383-92. 1997..riboprobes and monoclonal antibodies to characterize tissue distribution of the human 550-kD homologue to gp330/megalin, primarily identified in the rat kidney...
- Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptideS M Hammad
Cell Biology and Anatomy Department, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
J Biol Chem 272:18644-9. 1997..We have previously demonstrated that the endocytic receptor low density lipoprotein receptor-related protein-2/megalin (LRP-2), which is expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and ..
- Megalin is an endocytic receptor for insulinR A Orlando
Department of Pathology, University of California, San Diego, La Jolla 92093 0651, USA
J Am Soc Nephrol 9:1759-66. 1998..By immunoprecipitation it was demonstrated that this binding site is megalin, the large multiligand binding endocytic receptor that is abundantly expressed in clathrin-coated pits on the ..
- Megalin and cubilin: multifunctional endocytic receptorsErik Ilsø Christensen
Department of Cell Biology, University of Aarhus, University Park, Building 234, DK 8000 Aarhus C
Nat Rev Mol Cell Biol 3:256-66. 2002..b>Megalin and cubilin are two structurally different endocytic receptors that interact to serve such functions...
- Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesisAkihiko Saito
Department of Applied Molecular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
Nephrology (Carlton) 10:S26-31. 2005b>Megalin is an endocytic receptor on the apical membranes of proximal tubule cells (PTC) in the kidney, and is involved in the reabsorption and metabolism of various proteins that have been filtered by glomeruli...
- The role of megalin (LRP-2/Gp330) during developmentCarolyn E Fisher
Centre for Inflammation Research, Queen s Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH 16 4JT, Scotland, UK
Dev Biol 296:279-97. 2006b>Megalin (LRP-2/GP330), a member of the LDL receptor family, is an endocytic receptor expressed mainly in polarised epithelial cells...
- Genetic association of low-density lipoprotein receptor-related protein 2 (LRP2) with plasma lipid levelsAkiko Mii
Department of Internal Medicine, Divisions of Neurology, Nephrology, and Rheumatology, Nippon Medical School, Tokyo, Japan
J Atheroscler Thromb 14:310-6. 2007..We studied the association between the low density lipoprotein-related protein 2 gene (LRP2) and levels of plasma total cholesterol (T-Cho) and LDL-cholesterol (LDL-C) among 352 adults in Japan...
- A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese populationLi ling Wang
Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Clin Chim Acta 412:268-70. 2011LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD)...
- A genome-wide association study on common SNPs and rare CNVs in anorexia nervosaK Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Mol Psychiatry 16:949-59. 2011..In conclusion, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN. These results point to intriguing genes that await further validation in independent cohorts for confirmatory roles in AN...
- Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptorR Raychowdhury
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Science 244:1163-5. 1989..of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes. Partial complementary DNAs coding for GP330 were isolated and sequenced...
- A megalin polymorphism associated with promoter activity and Alzheimer's disease riskTeo Vargas
Neuroscience Laboratory, Research Center, Hospital 12 de Octubre, Madrid, Spain
Am J Med Genet B Neuropsychiatr Genet 153:895-902. 2010..This observation suggests that many, perhaps most, cases of AD are caused by faulty clearance of Abeta. Megalin, which plays an important role in mediating Abeta clearance, is an attractive candidate gene for genetic ..
- gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complexS Stefansson
Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Cell Sci 108:2361-8. 1995b>Glycoprotein 330 (gp330) is a member of a family of receptors related to the low density lipoprotein receptor (LDLR)...
- The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330M Z Kounnas
Holland Laboratory, American Red Cross, Rockville, Maryland 20855
J Biol Chem 267:21162-6. 1992..Here we show that RAP binds another putative receptor, the kidney glycoprotein 330 (gp330)...
- Analysis of glomeruli-eluted Gp330 autoantibodies and of Gp330 antigen of Heymann nephritisS P Makker
Department of Pediatrics, University of California, Davis 95616
J Immunol 151:6500-8. 1993Quantity, charge, IgG isotype, Ag reactivity of glomerular gp330 autoantibodies (gp330Ab), and the charge of the putative Ag, gp330, were studied in active Heymann nephritis. Gp330 was anionic with an isoelectric point of 4.6...
- Gene expression and immunohistochemical localization of megalin in the anterior pituitary gland of helmeted guinea fowl (Numida meleagris)Claudius Luziga
Laboratory of Comparative Endocrinology and Molecular Biological Studies, United Graduate School of Veterinary Sciences, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
J Mol Histol 38:65-77. 2007b>Megalin/the low density lipoprotein receptor-related protein-2 (LRP-2) is expressed in a variety of epithelia and mediates endocytosis of numerous substances. Megalin is also shown to bind clusterin with high affinity...
- Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriersB V Zlokovic
Department of Neurological Surgery, Childrens Hospital, Los Angeles, CA, USA
Proc Natl Acad Sci U S A 93:4229-34. 1996..the present study, we examined the transport process in greater detail and investigated the possible role of glycoprotein 330 (gp330)/megalin, a receptor for multiple ligands, including apoJ...
- Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cordGrzegorz Wicher
Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
J Comp Neurol 492:123-31. 2005The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
- Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexusJ T Chun
Andrus Gerontology Center and Department of Biological Sciences, Children s Hospital of Los Angeles, Los Angeles, California 90033, USA
Exp Neurol 157:194-201. 1999Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS)...
- Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cellsM Lundstrom
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651
Am J Pathol 143:1423-35. 1993..Studies of gp330 and receptor-associated protein (RAP), its 44-kd subunit, have been restricted largely to rat kidney, as no stable ..
- Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptorOlav A Gressner
Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
Clin Chim Acta 390:28-37. 2008....
- Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centersMichael S Okun
Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Arch Neurol 62:1250-5. 2005Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure...
- Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ERD Biemesderfer
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 3289
Am J Physiol 264:F1011-20. 1993The Heymann nephritis antigenic complex (HNAC) consists of two components, i.e., 1) gp330, a large glycoprotein localized in coated pits of the proximal tubule and glomerular epithelium, and 2) a 44-kDa protein which is homologous to the ..
- Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated proteinR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA
J Am Soc Nephrol 6:61-7. 1995The Heymann nephritis antigenic complex (HNAC) consists of two glycoproteins, megalin (gp330), and the receptor-associated protein (RAP)...
- Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complexR A Orlando
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093
Proc Natl Acad Sci U S A 90:4082-6. 1993b>gp330 is a large glycoprotein located in clathrin-coated pits at the surface of the glomerular and proximal tubule epithelia in the rat kidney...
- Human cytomegalovirus: detection of congenital and perinatal infection in ArgentinaAngélica Lidia Distéfano
Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
BMC Pediatr 4:11. 2004..of the polymerase chain reaction (PCR) technique with different pairs of primers, to detect cytomegalovirus isolated in tissue cultures and directly in urine and dried blood spot (DBS) specimens. Results were compared with IgM detection.
- Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubuleS Le Panse
Department of Cell Biology, University of Aarhus, Denmark
Exp Nephrol 5:375-83. 1997..We utilized a yolk sac teratocarcinoma cell line, BN/MSV, which expresses two glycoproteins, megalin/gp330 and gp280, also detected in renal proximal tubule and yolk sac epithelial cells...
- Dental fear and pain: effect on patient's perception of the dentistK H Kunzelmann
Polyclinic for Dental Care and Parodontology, Erlangen, FRG
Community Dent Oral Epidemiol 18:264-6. 1990A questionnaire was developed including the Dental Anxiety Scale (DAS) and the Dental Beliefs Survey (DBS) as subscales to examine the epidemiology of dental fear and dental beliefs in Germany...
- Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domainsMaria Paz Marzolo
Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Traffic 4:273-88. 2003b>Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large members of the LDL receptor family that bind and endocytose multiple ligands...
- Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cellsM L Elkjaer
Department of Cell Biology, University of Aarhus, Denmark
Eur J Cell Biol 67:57-72. 1995..organization of the apical endocytic apparatus, 2) apical endocytosis, and 3) subcellular distribution of gp330 and Aquaporin-1 water channels in renal proximal tubule cells...
- Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremorJan Herzog
Department of Neurology, Christian Albrechts University Kiel, Germany
Brain 130:1608-25. 2007Deep brain stimulation of the thalamus (thalamic DBS) is an established therapy for medically intractable essential tremor and tremor caused by multiple sclerosis...
- [Deep brain stimulation for treatment of dystonia and tremor]L Timmermann
Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
Nervenarzt 81:680-7. 2010Deep brain stimulation (DBS) is a safe and successful therapeutic option for patients with dystonia and tremor syndrome who do not respond sufficiently to conservative therapies...
- Induction of Heymann nephritis with a gp330/megalin fusion proteinR Raychowdhury
Department of Pathology, Massachusetts General Hospital, Charlestown 02129, USA
Am J Pathol 148:1613-23. 1996..the principal antigen is part of the extracellular domain of a cell surface glycoprotein receptor called gp330 or megalin. It has also been reported that the immunogen that induces Heymann nephritis is a complex formed between gp330 ..
- Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scansWieslaw L Nowinski
Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
J Neurosurg 113:1234-41. 2010The most severe complication of deep brain stimulation (DBS) is intracranial hemorrhage. Detailed knowledge of the cerebrovasculature could reduce the rate of this disorder...
- Deep brain stimulation for dystonia in adults. Overview and developmentsJoachim K Krauss
Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
Stereotact Funct Neurosurg 78:168-82. 2002..Deep brain stimulation (DBS) has been used only since a few years in dystonia patients...
- Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acidAndré Bento-Abreu
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
J Neurochem 111:49-60. 2009..the neurotrophic factor oleic acid requires internalization of albumin into the astrocyte, which is mediated by megalin. In this study, we show that the binding and internalization of albumin involve its interaction with megalin, ..
- Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cellsMichael Gekle
Physiologisches Institut, Wurzburg, Germany
J Physiol 552:471-81. 2003..An important function of proximal tubular cells is reabsorption of filtered proteins, including albumin, via megalin-cubilin-dependent receptor-mediated endocytosis...
- Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionSuresh B Boppana
UAB Department of Pediatrics, CHB 114, 1600 Sixth Ave S, Birmingham, AL 35233, USA
JAMA 303:1375-82. 2010..Since dried blood spots (DBS) are routinely collected for metabolic screening from all newborns in the United States, there has been interest in ..
- Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditisM Marino
Pathology Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
J Clin Endocrinol Metab 84:2468-74. 1999b>Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is a high-affinity receptor for thyroglobulin...
- Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson diseaseAntonella Peppe
Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
J Neurosurg 101:195-200. 2004The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
- Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremorTakashi Morishita
Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
J Neurosurg 112:491-6. 2010..recording (MER) and macrostimulation (test stimulation) are used to refine the optimal deep brain stimulation (DBS) lead placement within the operative setting...
- Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principleYoung Min Shon
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neurosurg 112:539-48. 2010..local adenosine efflux may contribute to the therapeutic mechanism of action of thalamic deep brain stimulation (DBS) for essential tremor...
- Deep brain stimulation between 1947 and 1987: the untold storyMarwan I Hariz
Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
Neurosurg Focus 29:E1. 2010Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery...
- Deep brain stimulation for camptocormia in dystonia and Parkinson's diseaseHans Holger Capelle
Department of Neurosurgery, Medical School Hannover, MHH, Carl Neuberg Strase 1, 30652, Hannover, Germany
J Neurol 258:96-103. 2011..Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect ..
- Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritisAlfonso Tramontano
Department of Pediatrics, University of California School of Medicine, Davis, CA 95616, USA
J Immunol 172:2367-73. 2004..Heymann nephritis (AHN), a rat model of autoimmune glomerulonephritis, is induced by immunization with autologous megalin, a 600-kDa cell surface glycoprotein isolated from crude renal extracts...
- [Deep brain stimulation for Parkinson's disease and dystonia]Fusako Yokochi
Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
Brain Nerve 61:473-83. 2009Deep brain stimulation (DBS) has proved highly effective in the treatment for Parkinson's disease and dystonia...
- Deep brain stimulation of two unconventional targets in refractory non-resectable epilepsyAngelo Franzini
Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
Stereotact Funct Neurosurg 86:373-81. 2008..Adrian Upton in 1985 proposed deep brain stimulation (DBS) of the anterior nucleus of the thalamus for the treatment of seizures and psychosis [Cooper I.S., Upton A.R...
- Reliability and clinical usefulness of psychometric measures in a self-referred population of odontophobicsR Moore
Royal Dental College, Department of Child Dental Health and Community Dentistry, Aarhus, Denmark
Community Dent Oral Epidemiol 19:347-51. 1991..were also tested before and after dental fear treatment with the following scales; a Getz Dental Belief Survey (DBS), Dental Fear Survey (DFS), and a Mood Adjective Checklist (MACL)...
- Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodesRichard A Wennberg
Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
Clin Neurophysiol 114:1403-18. 2003To examine interictal epileptiform and sleep potentials recorded intracranially from deep brain stimulation (DBS) electrodes in patients treated with DBS for epilepsy...
- Aggregation and adsorption of reactive dyes in the presence of an anionic surfactant on mesoporous aminopropyl silicaAntonio R Cestari
Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49100 000, Sao Cristovao, Sergipe, Brazil
J Colloid Interface Sci 309:402-11. 2007..of a yellow and a red dye in relation to the presence of the anionic surfactant sodium dodecylbenzene sulfonate (DBS) and to temperature changes in buffered aqueous solutions...
- Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330J J Kanalas
Department of Pediatrics, University of Texas Health Science Center at San Antonio 78784 7813
Arch Biochem Biophys 299:255-60. 1992Previously, we demonstrated that the Heymann nephritis autoantigen, gp330, can serve as a receptor site for plasminogen...
- The incidence of seizures following Deep Brain Stimulating electrode implantation for movement disorders, pain and psychiatric conditionsE Coley
Dept Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
Br J Neurosurg 23:179-83. 2009Deep Brain Stimulation (DBS) for neuromodulation is now commonplace. However little is known about the incidence of either procedural related seizures or epilepsy following chronic DBS...
- Deep brain stimulation for secondary dystonia: results in 8 patientsP F Katsakiori
Functional Neurosurgery Unit, Department of Neurosurgery, School of Medicine, University of Patras, 265 00, Rion, Greece
Acta Neurochir (Wien) 151:473-8; discussion 478. 2009..Deep Brain Stimulation (DBS) has been used successfully in various forms of dystonia...
- Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic reviewShaheen E Lakhan
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
BMC Res Notes 3:60. 2010..Although still in the experimental stage, deep brain stimulation (DBS) offers many advantages over other physically-invasive procedures as a treatment for these psychiatric disorders...
- Interactions between deep brain stimulation and levodopa in Parkinson's diseaseJ G Nutt
Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
Neurology 57:1835-42. 2001To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS.
- Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programmingMichael S Okun
Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
J Neurol Neurosurg Psychiatry 78:310-4. 2007Recently, anterior limb of the internal capsule and nucleus accumbens deep brain stimulation (DBS) has been used in the treatment of medication-refractory obsessive-compulsive disorder (OCD)...
- Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trialMichael S Okun
Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
Ann Neurol 65:586-95. 2009Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
- Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targetingClement Hamani
Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
J Neurosurg 111:1209-15. 2009Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG), including Brodmann area 25, is currently being investigated for the treatment of major depressive disorder (MDD)...
- Thalamic deep brain stimulation: comparison between unilateral and bilateral placementW Ondo
Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
Arch Neurol 58:218-22. 2001Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the tremor of Parkinson disease (PD)...
- Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiationRaghunatha R Yammani
Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002The role of the renal apical brush-border membrane (BBM) endocytic receptors cubilin and megalin in the onset of albuminuria in rats exposed to a single dose of total body irradiation (TBI) has been investigated...
- Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus--initial experienceMicheal D Phillips
Departments of Radiology, Neurology, and Neurosurgery, Cleveland Clinic Foundation, Mellen Center U 15, 9500 Euclid Ave, Cleveland, OH 44195, USA
Radiology 239:209-16. 2006..the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) of subthalamic nucleus (STN) for treatment of Parkinson disease and to determine the safety of DBS electrode ..
- A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD)...
- Anticonvulsant serotonergic and deep brain stimulation in anterior thalamusMarek A Mirski
Department of Anesthesia and Critical Medicine, Baltimore, MD, USA
Seizure 18:64-70. 2009..Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and ..
- Long-term effects of pallidal deep brain stimulation in tardive dystoniaD Gruber
Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
Neurology 73:53-8. 2009..immediate improvement of motor symptoms in patients with tardive dystonia after pallidal deep brain stimulation (DBS)...
- Activation of the NMDA receptor involved in the alleviating after-effect of repeated stimulation of the subthalamic nucleus on motor deficits in hemiparkinsonian ratsHisanao Akita
Department of Physiology, School of Allied Health Sciences, Kitasato University, Sagamihara 228 8555, Japan
Brain Res 1306:159-67. 2010..the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves ..
- A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohortHoutan A Taba
Department of Neurology, University of Forlida Movement Disorders Center, College of Medicine, University of Florida, Gainesville, FL 32611, USA
J Neurosurg 113:1224-9. 2010In this paper, the authors' aim was to examine reasons underpinning decisions to undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).
- Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleusLaura B Zahodne
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
J Neurol 256:1321-9. 2009While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
- Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high-molecular-weight glycoprotein antigen common to the kidney and teratocarcinomasM Nakamoto
Department of Biochemistry, Faculty of Medicine, Kagoshima University
J Biochem 114:344-9. 1993..Brushin was shown to be the mouse counterpart of rat Heymann nephritis antigen, called gp330. The association between HBP-44 and brushin was revealed not only by co-precipitation upon indirect ..
- Introduction to the programming of deep brain stimulatorsJens Volkmann
Department of Neurology, Christian Albrechts University, Kiel, Germany
Mov Disord 17:S181-7. 2002The clinical success of deep brain stimulation (DBS) for treating Parkinson's disease, tremor, or dystonia critically depends on the quality of postoperative neurologic management...
- 300-Hz subthalamic oscillations in Parkinson's diseaseG Foffani
Department of Neurological Sciences, Universita di Milano, IRCCS Ospedale Maggiore di Milano, Milano, Italy
Brain 126:2153-63. 2003..Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for complicated Parkinson's disease, but how DBS acts ..
- [Dried blood spot Vitamin A determination by high pressure liquid chromatography with electrochemical detection]P Houze
Laboratoire de Biochimie A, Hopital Saint Louis, Paris
Ann Biol Clin (Paris) 62:539-46. 2004..Sample collection on Dried Blood Spot (DBS) is less invasive and safer. Sample storage is easier...
- Double electrodes simultaneous stimulation and implantation technique in deep brain stimulationLiu guan Bian
Department of Neurosurgery, Ruijin Hospital, Shanghai Second Medical University, China
Chin J Traumatol 8:253-6. 2005..Nowadays, deep brain stimulation (DBS) confirms its efficacy in alleviating different forms of tremor, including posttraumatic tremor...
- Hepatitis B surface antigenaemia and alpha-foetoprotein detection from dried blood spots: applications to field-based studies and to clinical care in hepatitis B virus endemic areasM Mendy
Medical Research Council Fajara, Banjul, The Gambia, West Africa
J Viral Hepat 12:642-7. 2005..available kits for detection of HBV surface antigen (HBsAg) and alpha-foetoprotein (AFP) in dried blood spots (DBS) collected on filter paper...
- Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's diseaseIrene Rozet
Department of Anesthesiology, University of Washington, Seattle, Washington, USA
Anesth Analg 103:1224-8. 2006..the alpha-2 agonist dexmedetomidine (Dex) suggests that it may be an ideal sedative drug for deep brain stimulator (DBS) implantation...
- Extradural cortical stimulation for movement disordersS Canavero
Turin Advanced Neuromodulation Group, Turin, Italy
Acta Neurochir Suppl 97:223-32. 2007..with low morbidity-mortality which can be applied to patients who are excluded from deep brain stimulation (DBS), led to the first attempt of MCS in Parkinson's disease (PD)...
- Characteristics and distribution of somatosensory evoked potentials in the subthalamic regionMayumi Kitagawa
Department of Neurology, Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan
J Neurosurg 107:548-54. 2007..Determination of this distribution may help in the correct placement of deep brain stimulation (DBS) leads.
- Automated electronic tongue based on potentiometric sensors for the determination of a trinary anionic surfactant mixtureMontserrat Cortina
Sensors and Biosensors Group, Department of Chemistry, Autonomous University of Barcelona, Edifici Cn, 08193 Bellaterra, Spain
J Pharm Biomed Anal 46:213-8. 2008..Dodecylsulfate (DS(-)), dodecylbenzenesulfonate (DBS(-)) and alpha-alkene sulfonate (ALF(-)) formed the three-analyte study case resolved in this work...
- [Reversible hypogeusia during bilateral thalamic stimulation for essential tremor]J Roggendorf
Klinik fur Neurologie, Johann Wolfgang Goethe Universitat, Schleusenweg 2 16, 60528, Frankfurt, Deutschland
Nervenarzt 79:454-6. 2008Deep brain stimulation of ventral intermediate nucleus (VIM-DBS) has become an established therapy for severe essential tremor (ET)...
- Pallidal deep brain stimulation is effective, and improves quality of life in primary segmental and generalized dystoniaI M Skogseid
Department of Neurology, Division of Clinical Neuroscience, Rikshospitalet University Hospital HF, Oslo, Norway
Acta Neurol Scand Suppl 188:51-5. 2008..In widespread segmental or generalized dystonia efficient treatment options were lacking until the recent introduction of deep brain stimulation of the internal globus pallidus (pallidal DBS).
- Are two leads always better than one: an emerging case for unilateral subthalamic deep brain stimulation in Parkinson's diseaseJay L Alberts
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Exp Neurol 214:1-5. 2008Bilateral subthalamic (STN) deep brain stimulation (DBS) provides significant symptom relief for the majority of well-screened patients suffering with Parkinson's disease (PD)...
- Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuriaYaeko Motoyoshi
Department of Bioethics, Tokai University School of Medicine, Isehara City, Kanagawa, Japan
Kidney Int 74:1262-9. 2008b>Megalin, a member of the LDL receptor family, is expressed on the apical membrane of proximal tubules and serves as an endocytic scavenger of filtered proteins and hence might contribute to the tubule injury as a consequence of ..
- Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillationsKevin W McCairn
Department of Neurobiology, University of Pittsburgh, 4047 BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
J Neurophysiol 101:1941-60. 2009Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease...
- The mechanism of dead-in-bed syndrome and other sudden unexplained nocturnal deathsB Parekh
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
Curr Diabetes Rev 5:210-5. 2009The mechanism of dead-in-bed syndrome (DBS), a rare but devastating condition that mainly affects young type 1 diabetes patients, remains mysterious. A new theory is proposed to explain this syndrome...
- Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's diseaseNuri Firat Ince
Departments of Neurosurgery and Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
Neurosurgery 67:390-7. 2010..used surgical treatment for patients with Parkinson's disease is the implantation of deep brain stimulation (DBS) electrodes within the subthalamic nucleus...
- Deep brain stimulation in clinical trials and animal models of depressionClement Hamani
Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
Eur J Neurosci 32:1109-17. 2010Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression...
- Gilles de la Tourette syndrome and deep brain stimulationMarwan I Hariz
Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Eur J Neurosci 32:1128-34. 2010..In severe GTS patients who are refractory to medication and other therapies, deep brain stimulation (DBS) is investigated. To date there have been some 50-55 patients who have received DBS in 19 centres worldwide...
- Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?Sonny K H Tan
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Neuropharmacology 61:387-99. 2011..These findings include evidence that clinical depression is a side effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN), a treatment option in advanced PD...
- Graphene oxide based Pt-TiO2 photocatalyst: ultrasound assisted synthesis, characterization and catalytic efficiencyBernaurdshaw Neppolian
The School of Chemistry, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
Ultrason Sonochem 19:9-15. 2012..photocatalytic and sonophotocatalytic degradation of a commonly used anionic surfactant, dodecylbenzenesulfonate (DBS), in aqueous solution was carried out using Pt-GO-TiO2 nanoparticles in order to evaluate the photocatalytic ..
- Model-based analysis and control of a network of basal ganglia spiking neurons in the normal and parkinsonian statesJianbo Liu
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48823, USA
J Neural Eng 8:045002. 2011..may provide plausible explanations for the mechanisms underlying the therapeutic effects of deep brain stimulation (DBS) in Parkinson's disease and pave the way towards a model-based, network level analysis and closed-loop control and ..
- Deep brain stimulation induces rapidly reversible transcript changes in Parkinson's leucocytesLilach Soreq
Department of Medical Neurobiology Physiology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
J Cell Mol Med 16:1496-507. 2012Subthalamic deep brain stimulation (DBS) reversibly modulates Parkinson's disease (PD) motor symptoms, providing an unusual opportunity to compare leucocyte transcripts in the same individuals before and after neurosurgery and 1 hr after ..
- Quantification of HIV-RNA from dried blood spots using the Siemens VERSANT® HIV-1 RNA (kPCR) assayMaria Franca Pirillo
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
J Antimicrob Chemother 66:2823-6. 2011..We evaluated the performance of the VERSANT(®) HIV-1 RNA (kPCR) assay for the determination of HIV-1 viral load from dried blood spots (DBS). Assay sensitivity and correlation with plasma quantification values were assessed.
- Explaining clinical effects of deep brain stimulation through simplified target-specific modeling of the volume of activated tissueB Madler
Division of Stereotaxy and MR Based Operative Techniques, Department of Neurosurgery, Bonn University Hospital, Bonn, Germany
AJNR Am J Neuroradiol 33:1072-80. 2012Although progress has been made in understanding the optimal anatomic structures as target areas for DBS, little effort has been put into modeling and predicting electromagnetic field properties of activated DBS electrodes and ..
- Deep-brain stimulation for anorexia nervosaHemmings Wu
Laboratory of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, Leuven, Belgium
World Neurosurg 80:S29.e1-10. 2013..After decades of brain-lesioning procedures offered as a last resort, deep-brain stimulation (DBS) has come under investigation in the last few years as a treatment option for severe and refractory AN.
- The impact of brain shift in deep brain stimulation surgery: observation and obviationP J Slotty
Neurochirurgische Klinik, Heinrich Heine Universitat Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Germany
Acta Neurochir (Wien) 154:2063-8; discussion 2068. 2012The impact of brain shift on deep brain stimulation surgery is considerable. In DBS surgery, brain shift is mainly caused by CSF loss. CSF loss can be estimated by post-surgical intracranial air...
- Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and IIIJessica de Ruijter
Department of Pediatrics and Amsterdam Lysosome Centre Sphinx, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Mol Genet Metab 107:705-10. 2012..and sensitive method to measure levels of dermatan and heparan sulfate derived disaccharides in dried blood spots (DBS) with HPLC-MS/MS, and show that this reliably separates MPS I, II and MPS III newborns from controls and ..
- Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, UgandaImke H Bartelink
Department of Clinical Pharmacy, Drug Research Unit, University of California, San Francisco, CA, USA
J Clin Pharmacol 54:121-32. 2014..In 2011, 62/225 ante-partum/post-partum single dried blood spot samples DBS and 43 post-partum hair samples for LPV/r were derived from 116 women, 51/194 ante-/post-partum DBS and 53 post-..
- Parkin mutation and deep brain stimulation outcomeHee Jin Kim
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea
J Clin Neurosci 21:107-10. 2014Patients with parkin mutations are expected to be good candidates for deep brain stimulation (DBS) because of an excellent levodopa response and frequent occurrence of levodopa-induced dyskinesia...
- Anti-anhedonic effect of deep brain stimulation of the prefrontal cortex and the dopaminergic reward system in a genetic rat model of depression: an intracranial self-stimulation paradigm studyEllis Rea
International Graduate Program Medical Neurosciences, Charite University Hospital, Berlin, Germany
Brain Stimul 7:21-8. 2014..In recent years, deep brain stimulation (DBS) has evolved as a potential tool to modulate pathological neural activity; stimulation of the subgenual cingulate (..
- JAIME A KAMINER; Fiscal Year: 2014..Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) stimulation will be applied to 6-OHDA lesioned ..
- MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PDTAMARA G HERSHEY; Fiscal Year: 2012..mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
- Miguel A L Nicolelis; Fiscal Year: 2014..The electrical stimulation of subcortical areas of the brain (deep brain stimulation - DBS) is an effective alternative option, which is rather restricted due to its invasiveness and associated risks...
- Michelle M McCarthy; Fiscal Year: 2016..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that ..
- ROBERT STERLING TURNER; Fiscal Year: 2015..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing abnormalities in GPi ..
- Jerrold L Vitek; Fiscal Year: 2016..Despite the widespread use of DBS, its mechanism of action remains unclear...
- Deep Brain Stimulation in Parkinson's ModelsMarjorie Anderson; Fiscal Year: 2006DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
- Scheduled and Responsive Brain Stimulation for the Treatment of Tourette SyndromeMichael S Okun; Fiscal Year: 2010..Chronic high frequency deep brain stimulation (DBS) has recently emerged as a possible therapeutic option in refractory cases incapacitated by their tics...
- DBS of the pedunculopontine nucleus in Parkinsonian primateJerrold L Vitek; Fiscal Year: 2010..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy ..
- Arrays for deep brain microstimulation and recordingDOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010Electrical stimulation in deep brain structures (DBS) has developed into an effective treatment for advanced Parkinson's disease and essential tremor...
- STN Stimulation: Neural Control of Movement and PostureDANIEL MONTIE CORCOS; Fiscal Year: 2011High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
- Jerrold L Vitek; Fiscal Year: 2016..motor signs in Parkinson's disease (PD), and the improvement in motor function during deep brain stimulation (DBS)...
- CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBSWENDY LOMBARDI; Fiscal Year: 2003..of cortical activation on functional MRI (fMRI), that the cognitive and motor effects of deep brain stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the frontal lobe to ..
- EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROLFay Horak; Fiscal Year: 2005..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor ..
- DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PDRobert Turner; Fiscal Year: 2006DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's ..
- Evaluation of MRI Safety for Deep Brain StimulationAli Rezai; Fiscal Year: 2004There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and ..
- Cortical and basal ganglia local field potentials in human movement disordersPhilip A Starr; Fiscal Year: 2012..and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
- Daniel K Leventhal; Fiscal Year: 2016..electrophysiological experiments in human subjects, and have clinical duties in the Movement Disorders and DBS programs...
- Systems-Level Model of Deep Brain StimulationCameron McIntyre; Fiscal Year: 2013DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of medically refractory Parkinson's disease (PD)...
- Controlled Trial of DBS for OCDBenjamin D Greenberg; Fiscal Year: 2010..Our three collaborative pilot studies suggest that deep brain stimulation (DBS) of the ventral anterior limb of internal capsule and adjacent ventral striatum (VC/VS) is effective in otherwise ..
- HARRISON CARROLL WALKER; Fiscal Year: 2014DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies, cell transplant strategies, and the delivery of gene-delivered growth factors ..
- Mechanism of Action of Deep Brain StimulationKendall H Lee; Fiscal Year: 2012..neuroengineering and neurosurgery will help the applicant elucidate the mechanisms by which Deep Brain Stimulation (DBS) treats Parkinson's disease...
- Ethics of Control and Consent in Brain Stimulation for Parkinson DiseaseCYNTHIA M S KUBU; Fiscal Year: 2010..the ethical challenges inherent in participants'considerations of control using Deep Brain Stimulation (DBS) for the treatment of Parkinson disease (PD) as a paradigm...
- JOEL SYNES PERLMUTTER; Fiscal Year: 2015DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) dramatically improves motor function and quality of life in PD yet may alter cognitive skills and mood (Progress Report)...
- Time Course of Subthalamic Deep Brain StimulationScott E Cooper; Fiscal Year: 2011..research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS). STN DBS is a highly effective, widely used treatment for Parkinson's disease (PD)...
- Brandon S Bentzley; Fiscal Year: 2015..drug rewards is reversible in rats by lesioning subthalamic nucleus (STN) bilaterally or by deep brain stimulation (DBS) in STN, as is done for treatment of Parkinson's disease...
- Comparison of Unilateral and Bilateral Subthalamic Stimulation in Parkinson'sJay L Alberts; Fiscal Year: 2012DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is a surgical procedure that is effective in improving the cardinal motor signs of advanced Parkinson's disease (PD)...
- Rat Model of Brain Stimulation in Parkinsonian ConditionJing Yu Chang; Fiscal Year: 2005Deep brain stimulation (DBS) has been used in the clinic to treat Parkinson's disease (PD) during the past decade. The neuronal mechanisms underlying the therapeutic effects of DBS, however, are yet to be clarified...
- Effects of DBS on sensorimotor processesJing Yu Chang; Fiscal Year: 2005..Deep brain stimulation (DBS) of subthalamic nucleus (STN) has been used increasingly in the clinic to alleviate Parkinsonian syndromes (PS) ..
- The Neuroprotective Effects of HF STN-DBSAnne Engemann; Fiscal Year: 2010DESCRIPTION (provided by applicant): High-frequency deep brain stimulation of the subthalamic nucleus (HF STN-DBS) is now the most frequently practiced surgical therapy for the treatment of Parkinson's disease (PD) with more than ..
- Cerebellar stimulation for the treatment of dystonia: preclinical studiesEllen J Hess; Fiscal Year: 2013..Deep brain stimulation (DBS) of the internal globus pallidus is another treatment option...
- FMRI Study of the Effects of DBS in Primary Generalized Dystonia (K23)Benjamin L Walter; Fiscal Year: 2010..Select centers around the world, including our own, are now using deep brain stimulation (DBS) to treat dystonia...
- Mechanisms of Pallidal Deep Brain StimulationMatthew Johnson; Fiscal Year: 2009DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the globus pallidus (GP) is an effective treatment for patients with advanced Parkinson's disease (PD)...
- Optical Coherence Domain Reflectometry in Brain ProbesAli Rezai; Fiscal Year: 2004..Refined guidance would greatly enhance the effectiveness and safety of deep-brain stimulation (DBS) with implanted electrodes...
- CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELSNicholas D Schiff; Fiscal Year: 2013..The goal of the proposed studies is to develop two complementary animal models to advance deep brain stimulation (DBS) of the central thalamus (CT) as a therapeutic strategy for the treatment of acquired cognitive disabilities ..
- Andre Guelman Machado; Fiscal Year: 2014..our results are promising and human translation is feasible given that the technology for deep brain stimulation (DBS) is already FDA approved for the treatment of movement disorders and has been proven safe in over 40,000 implants...
- Role of the midline thalamus in arousal, attention and cognitionROBERT PAUL VERTES; Fiscal Year: 2013..Schiff and colleagues demonstrated the remarkable findings that deep brain stimulation (DBS) of the midline thalamus in MCS patients restored a range of motor and cognitive functions that had long been ..
- MATTHEW DOUGLAS JOHNSON; Fiscal Year: 2015..motor symptoms are refractory to medication and significantly impair their daily living, deep brain stimulation (DBS) is considered to be the only therapeutic option...
- Anatomical and Physiological Characterization of the Thalamostriatal SystemKALYNDA GONZALES; Fiscal Year: 2012..system has generated significant interest recently because of clinical data showing that deep brain stimulation (DBS) of the centromedian/parafascicular (CM/PF) complex, the main sources of thalamic inputs to the striatum, ..
- David Eidelberg; Fiscal Year: 2014..Finally, in Specific Aim 3, we seek to understand how deep brain stimulation (DBS) works in dystonia when it does work, and identify predictors of patient response...
- Deep Brain Stimulation Array for NeuromodulationRio J Vetter; Fiscal Year: 2013DESCRIPTION (provided by applicant): Deep Brain Stimulation (DBS) devices - 'brain pacemakers'- have emerged as a revolutionary new approach to the treatment of neurological disorders...
- Temporal Patterns of Deep Brain StimulationWarren M Grill; Fiscal Year: 2013Chronic high frequency electrical stimulation of the brain, called deep brain stimulation (DBS), has evolved from a highly experimental technique to a well-established therapy for the treatment of movement disorders including dystonia, ..
- Peter E Konrad; Fiscal Year: 2014..However, DBS therapy is currently limited by an incomplete understanding of DBS mechanisms of action due to complexity of the ..
- Deep Brain Stimulation Array for NeuromodulationRIO VETTER; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
- Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig ModelWilliam P Melega; Fiscal Year: 2010..Known as deep brain stimulation (DBS), it has been successfully used to treat various human brain disorders (e.g...
- Mary Bartlett Bunge; Fiscal Year: 2016..to make the caudal interface more permissive to axon growth and clinically relevant deep brain stimulation (DBS) and genetic approaches to enhance the intrinsic growth potential of injured brainstem neurons...
- AMY WILLIS AMARA; Fiscal Year: 2016..Sleep disorders are common, affecting 74-98% of PD patients (1, 5). Deep brain stimulation (DBS) of the sub thalamic nucleus (STN) effectively controls motor symptoms in advanced PD (6-8)...
- The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional ProcessingJoseph S Neimat; Fiscal Year: 2012..Over the past decade, deep brain stimulation (DBS) has become an increasingly important tool in the treatment of movement disorders...
- Kendall H Lee; Fiscal Year: 2015DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is an effective neurosurgical approach for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, epilepsy, and ..
- Itzhak Fried; Fiscal Year: 2016..in the New England Journal of Medicine showing dramatic spatial memory enhancement when deep brain stimulation (DBS) of the human entorhinal area was given during the learning phase ...
- Emad N Eskandar; Fiscal Year: 2014DESCRIPTION (provided by applicant): Intellectual Merit: Deep brain stimulation (DBS) is a highly promising therapy for Parkinson's disease (PD)...
- ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2015..comparing and contrasting the effects of optogenetic manipulations to the effects of deep brain stimulation (DBS) will help illuminate the exact mechanism of action of DBS, which remains unclear...
- JOSEPH GIUFFRIDA; Fiscal Year: 2014..include pharmaceutical interventions such as levodopa and surgical procedures such as deep brain stimulation (DBS). It is important to accurately quantify motor function and disability in PD to assess intervention efficacy...
- Neural Circuit Basis of Behavioral Susceptibility and Resilience to Social DefeatJESSICA JILLIAN WALSH; Fiscal Year: 2013..Recent studies have shown Deep Brain Stimulation (DBS) to be robustly efficacious in treating MDD patients and thus research has focused on discovering the underlying ..
- Striatal Origin of Pathological Beta Oscillations in Parkinson's DiseaseXue Han; Fiscal Year: 2013..Newer therapies such as deep brain stimulation (DBS) highlight the fact that PD involves neural network pathology...
- Constantine G Lyketsos; Fiscal Year: 2016..The urgent need for the development of novel, non-amyloid therapies, the efficacy of deep brain stimulation (DBS) in neuropsychiatric disorders (e.g...
- Apparatus for placing electrodes for deep-brain stimulationJ Michael Fitzpatrick; Fiscal Year: 2012..to explore the feasibility of a new device to guide the placement of electrodes for deep- brain stimulation (DBS)...
- Behavioral effects of deep brain stimulation in rats with chronic painTHOMAS JEFFREY MARTIN; Fiscal Year: 2013..The objectives of this proposal are: (1) to examine novel brain regions in which deep brain stimulation (DBS) reverses mechanical allodynia in rats following spinal nerve ligation (SNL), and (2) to determine the brain ..
- Paul Larson; Fiscal Year: 2016..By applying deep brain stimulation (DBS) to area LC of the caudate nucleus, pathological neural activity with perceptual consequences will either be ..
- ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2016..The novel aspect of this aim is the method of neuronal inactivation. We will utilize deep brain stimulation (DBS), a technique increasingly used clinically for the treatment of neurological diseases that has recently been tested ..
- COLLIN M CHALLIS; Fiscal Year: 2014..Additionally, deep brain stimulation (DBS) of the mPFC in both humans and animals produced an antidepressant-like effect...
- ZACHARY AARON RODD; Fiscal Year: 2014..Recent human studies have indicated that a neurosurgical procedure, deep brain stimulation (DBS), is effective at reducing alcohol consumption in alcoholics with a co-morbid psychological treatment (e.g...
- MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONSMark George; Fiscal Year: 2002DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
- Local field potentials in the basal gangliaTHOMAS N WICHMANN; Fiscal Year: 2010..Studies in humans, using implanted deep brain stimulation (DBS) electrodes to record LFPs, have suggested that high-amplitude, low frequency oscillations develop in parkinsonism ..
- DEEP BRAIN STIMULATION FOR PARKINSONS DISEASEJERROLD VITEK; Fiscal Year: 2005The major aim of this study is to carry out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced ..
- DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PDMarjan Jahanshahi; Fiscal Year: 2005DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
- FMRI Evaluation of DBS in Parkinson's DiseaseMICHEAL PHILLIPS; Fiscal Year: 2009..the changes in motor pathway activity produced by deep brain stimulation in the subthalamic nucleus (STN DBS) in patients with Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI)...
- WI State Public Health Lab Capacity for SCID ScreeningCHARLES DENNIS BROKOPP; Fiscal Year: 2010..we performed two large-scale studies to determine the feasibility of quantitating TRECs using dried blood spots (DBS) to detect SCID newborns...
- Trafficking of LRP and Megalin in Polarized CellsGuojun Bu; Fiscal Year: 2006DESCRIPTION (provided by applicant) Megalin and the low-density lipoprotein (LDL) receptor-related protein (LRP) are two large membrane glycoproteins that belong to the LDL receptor gene family...
- SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISMEdwin Naylor; Fiscal Year: 2000..of the very cost effective and accurate method for screening newborn infants using filter paper dried blood spots (DBS) can be applied to pediatric and adult populations to detect diseases before disability and severe symptoms develop,..
- SERUM PROTEIN BINDING THE HN AUTOANTIGENJOHN KANALAS; Fiscal Year: 1993..Although a glycoprotein isolated form the brush border (gp330) is generally recognized as the putative antigen of HN, it's normal function has yet to be determined...
- Motor Learning in Parkinson's DiseaseM Ghilardi; Fiscal Year: 2002..Specifically, we will pursue the following aims: 1. To study the effects of DBS and levodopa administration on motor learning in PD...
- Advanced Technology and Tools for DBS Programming for Speech FunctionalityCraig van Horne; Fiscal Year: 2009..Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders...