MCRS1

Summary

Gene Symbol: MCRS1
Description: microspherule protein 1
Alias: ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1, 58 kDa microspherule protein, INO80 complex subunit J, INO80 complex subunit Q, cell cycle-regulated factor (78 kDa), cell cycle-regulated factor p78
Species: human

Top Publications

  1. ncbi p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability
    Y Hirohashi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:4937-46. 2006
  2. ncbi The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120
    Y Ren
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 253:734-42. 1998
  3. ncbi Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration
    Ding Yen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11456, Taiwan, Republic of China
    J Biol Chem 277:25446-56. 2002
  4. ncbi Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
    Hai Song
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Biochem Biophys Res Commun 316:1116-23. 2004
  5. ncbi Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
    Keiko Shimono
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 280:39436-47. 2005
  6. ncbi The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 15:1525-38. 2006
  7. pmc RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
  8. doi Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway
    Hai Shi
    State Key Laboratory of Cancer Biology and Department of Gastrointestinal Surgery, Xijing Hospital, Xi an, China
    Cancer Sci 100:1585-90. 2009
  9. pmc Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex
    Yong Cai
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 285:4268-72. 2010
  10. pmc Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling
    Lu Chen
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 286:11283-9. 2011

Research Grants

Scientific Experts

  • Min Xia Liu
  • Hai Shi
  • Alaa S Awad
  • A Cox
  • Yun Wang
  • Jia Long Wu
  • Y Cao
  • Yuejun Fu
  • Lyudmyla G Glushakova
  • E C Davis
  • M Diaz Ricart
  • Gerald Warren Hart
  • Ting Huang
  • Xinwen Chen
  • Jing Zhang
  • Yong Cai
  • Wei Lin
  • Jian Zhang
  • Chuan Pin Yang
  • Rey Huei Chen
  • Ding Yen Lin
  • Sylvain Meunier
  • Jingji Jin
  • Mujun Zhao
  • Ronald C Conaway
  • Yi Chao Lee
  • Wen Chang Chang
  • Selene K Swanson
  • Michael P Washburn
  • Laurence Florens
  • Che Chia Hsu
  • Lin Wu
  • Sunil Jayaramaiah Raja
  • Koichi Okumura
  • Taro Ohkawa
  • Colleen M Noviello
  • Yongzhou Zhang
  • Amanda Garrido
  • Si Hyung Lee
  • Jens Durruthy-Durruthy
  • R F Godino
  • Nabil Djouder
  • Marta Brandt
  • Laetitia Davidovic
  • Chi Wu Chiang
  • Mohamad Ali Fawal
  • Giorgia Giolo
  • Mu Huo Ji
  • Jingtao Peng
  • Nicoletta Casartelli
  • Mei Hsiang Wu
  • Isabelle Vernos
  • Yi Huan Tsou
  • Chang Han Chen
  • Mario Benavides
  • Pauli Kallio
  • Takashi Kamada
  • Martin Marek
  • Jiang Wang
  • Chun Sheng Xu
  • Mafei Xu
  • Annamaria Tonazzi
  • Yanling Liu
  • Xiaohong Tan
  • Shi Li Han
  • Zhou Fei
  • Chung Wen Kuo
  • Iva Z Mathews
  • Federico Rodriguez-Porcel
  • Sabine Petry
  • Lu Tai Tien
  • Lu Chen
  • Girdhar G Sharma
  • Asifa Akhtar
  • Kun Li
  • Danielle S Counotte
  • Ditte Skovaa Andersen
  • Roxann C Harvey
  • Rajendra Kumar Singh
  • John C Guatelli
  • Joan W Conaway
  • Qian Wang
  • Joan Weliky Conaway
  • Libo Yao
  • Luis F Pacios
  • Antonios I Karagiannidis
  • Tsaiping Li
  • Jerry P Pian
  • Loy E Volkman
  • Matthew D Welch

Detail Information

Publications102 found, 100 shown here

  1. ncbi p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability
    Y Hirohashi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:4937-46. 2006
    ..Here, we demonstrate that both Nde1 and Su48 can associate with p78/MCRS1, a protein implicated in cancer development...
  2. ncbi The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120
    Y Ren
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 253:734-42. 1998
    ..Two positive clones encoded portions of a novel protein, designated microspherule protein 58 kDa (MSP58). MSP58 mRNA is 1...
  3. ncbi Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration
    Ding Yen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11456, Taiwan, Republic of China
    J Biol Chem 277:25446-56. 2002
    ..to identify Daxx-interacting protein(s), three independent clones encoding the 58-kDa microspherule protein (MSP58) fragments were identified...
  4. ncbi Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
    Hai Song
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Biochem Biophys Res Commun 316:1116-23. 2004
    ..A novel gene, MCRS2, encoding for an isoform of MCRS1/p78 and MSP58 was isolated. The expression of MCRS2 protein is cell-cycle dependent, accumulating in the very early S phase...
  5. ncbi Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
    Keiko Shimono
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 280:39436-47. 2005
    ..In exploring the role of nucleolar protein MCRS1 (microspherule protein1)/MSP58 (58-kDa microspherule protein), we found that Mi-2beta, a component of a nucleosome remodeling and deacetylase (..
  6. ncbi The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 15:1525-38. 2006
    ..Using a yeast two-hybrid system, we identified MicroSpherule Protein 58 (MSP58) as a novel FMRP-cellular partner...
  7. pmc RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
    b>MSP58, a 58-kD nuclear microspherule protein, is an evolutionarily conserved nuclear protein implicated in the regulation of gene transcription as well as in malignant transformation...
  8. doi Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway
    Hai Shi
    State Key Laboratory of Cancer Biology and Department of Gastrointestinal Surgery, Xijing Hospital, Xi an, China
    Cancer Sci 100:1585-90. 2009
    We have investigated the expression and role of the 58-kDa microspherule protein (MSP58) in colorectal carcinoma (CRC)...
  9. pmc Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex
    Yong Cai
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 285:4268-72. 2010
    ..with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex...
  10. pmc Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling
    Lu Chen
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 286:11283-9. 2011
    ..Taken together, our findings shed new light on the structure and function of the INO80 chromatin-remodeling complex...
  11. ncbi MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo
    Chun Sheng Xu
    The State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Asian Pac J Cancer Prev 13:3233-8. 2012
    ..Recently, MSP58 was shown to behave as an oncogene in colorectal carcinomas and gliomas...
  12. pmc Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells
    R Bruni
    The Marjorie B Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois 60637, USA
    J Virol 72:8525-31. 1998
    ..Here, we report the following. (i) ICP22 interacts with a previously unknown cellular factor designated p78 in the yeast two-hybrid system...
  13. ncbi DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription
    Xiulian Du
    Department of Pathology and Laboratory Medicine, 252 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:184-90. 2006
    ..In this study, we found that DIPA can associate with p78/MCRS/MSP58, a Forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation ..
  14. ncbi The physical and functional interaction of NDRG2 with MSP58 in cells
    Jing Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China 710032, China
    Biochem Biophys Res Commun 352:6-11. 2007
    ..Here, we identified MSP58, a 58-kDa microspherule protein, as an interacting partner of human Ndrg2 by using yeast two-hybrid screening...
  15. pmc MCRS2 represses the transactivation activities of Nrf1
    Jia Long Wu
    IBMS, Academia Sinica, Taipei 11529, Taiwan, ROC
    BMC Cell Biol 10:9. 2009
    ..Some functions of MCRS1 and its splice variant-MSP58 and MCRS2 have been previously identified, such as transforming, nucleolar sequestration, ribosomal gene ..
  16. ncbi PTEN: a novel anti-oncogenic function independent of phosphatase activity
    Koichi Okumura
    Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California 92093 0660, USA
    Cell Cycle 4:540-2. 2005
    ..We identified a novel protein that interacts with this domain, the v-jun transcriptional target, MSP58. Binding of MSP58 to PTEN results in the suppression of MSP58-mediated transformation...
  17. ncbi A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex
    Jingji Jin
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 280:41207-12. 2005
    ..Finally, we demonstrate that, similar to the yeast INO80 complex, the hINO80 complex exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding...
  18. doi Spontaneous seizures in a rat model of multiple prenatal freeze lesioning
    Takashi Kamada
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsy Res 105:280-91. 2013
    ..Brain tissues were examined immunohistochemically at P28 and P78 using semiquantitative densitometry. Eleven of 16 rats (68...
  19. pmc MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer
    Min Xia Liu
    Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Mol Cancer 13:245. 2014
    ..In this study, we observed that an overexpression of microspherule protein 1 (MCRS1) promotes the invasion and metastasis of non-small cell lung cancer (NSCLC) cells...
  20. doi Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice
    Mu Huo Ji
    Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
    Neurotoxicology 46:155-64. 2015
    ..In another separate experiment, mice were killed on day P8 or P78, and the brain tissues were harvested and then subjected to biochemistry studies...
  21. pmc Identification of a novel regulatory sequence of actin nucleation promoting factor encoded by Autographa californica multiple nucleopolyhedrovirus
    Yun Wang
    From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, 430071
    J Biol Chem 290:9533-41. 2015
    ..Autographa californica multiple nucleopolyhedrovirus (AcMNPV) nucleocapsid protein P78/83 is a virus-encoded NPF that contains a C-terminal VCA domain and induces actin polymerization in virus-infected ..
  22. doi MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation
    Mohamad Ali Fawal
    Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncologicas, CNIO, 28029 Madrid, Spain
    Dev Cell 33:67-81. 2015
    ..Here, we identify microspherule protein 1 (MCRS1) as the essential link between Rheb and mTORC1 activation...
  23. pmc Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)
    Chuan Pin Yang
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan, ROC
    J Biomed Sci 22:33. 2015
    b>MSP58 is a nucleolar protein associated with rRNA transcription and cell proliferation. Its mechanism of translocation into the nucleus or the nucleolus, however, is not entirely known...
  24. ncbi AcMNPV-mediated expression of BmK IT promotes the apoptosis of Sf9 cells and replication of AcMNPV
    Yue Jun Fu
    Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, China
    Sheng Li Xue Bao 67:305-11. 2015
    ..proteins (c-Myc, cleaved-Caspase3, Bcl-2 and Bax) of Sf9 cells, the transcription level of key genes (38K, C42, P78, F) of AcMNPV, and viral propagation assay demonstrated that AcMNPV-mediated expression of BmK IT promoted the ..
  25. pmc Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury
    Alaa S Awad
    Department of Medicine, Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 10:e0133777. 2015
    Our recent publication showed that a small bioactive pigment epithelium derived factor (PEDF) peptide (P78-PEDF) prevents the development of diabetic nephropathy (DN)...
  26. doi Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma
    Jingtao Peng
    Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, China
    Cancer Lett 369:167-74. 2015
    ..Here, we identified MCRS1 as a bona fide substrate for BAP1...
  27. pmc The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway
    MinXia Liu
    Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    J Exp Clin Cancer Res 34:121. 2015
    b>Microspherule protein 1 (MCRS1) is a candidate oncogene and participates in various cellular processes, including growth, migration, senescence and transformation...
  28. pmc Transport to Rhebpress activity
    Amanda Garrido
    a Cancer Cell Biology Program, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncologicas, CNIO, Madrid, Spain
    Small Gtpases 7:12-5. 2016
    ..We recently determined that microspherule protein 1 (MCRS1) maintains Rheb at lysosomal surfaces in an amino acid-dependent manner...
  29. pmc Aurora-A regulates MCRS1 function during mitosis
    Sylvain Meunier
    a Center for Genomic Regulation CRG, The Barcelona Institute of Science and Technology, Barcelona, Spain
    Cell Cycle 15:1779-86. 2016
    ..b>MCRS1 is a RanGTP target that specifically associates with the chromosome-driven MTs protecting them from MT ..
  30. pmc MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment
    Si Hyung Lee
    Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea
    Sci Rep 6:27284. 2016
    b>MCRS1 is involved in multiple cellular activities, including mitotic spindle assembly, mTOR signaling and tumorigenesis...
  31. doi Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency
    Jens Durruthy-Durruthy
    Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
    Dev Cell 38:100-15. 2016
    ..We identified in silico precursors of the epiblast and primitive endoderm lineages and revealed a role for MCRS1, TET1, and THAP11 in epiblast formation and their ability to induce naive pluripotency in vitro...
  32. doi RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription
    Chuan Pin Yang
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, 70101, Taiwan, ROC
    Biochem Biophys Res Commun 478:873-80. 2016
    ..The 58-kDa microspherule protein (MSP58) is a nucleolar protein involved in rDNA transcription and cell proliferation...
  33. pmc New polymorphism of the influenza virus resistance Mx1 gene in Iberian domestic pigs
    R F Godino
    Department of Ophthalmology, Ocular Genomics Institute Harvard Medical School, MEEI, Boston, MA USA
    Postdoc J 4:15-19. 2016
    i>Mx1 (Myxovirus (Influenza virus) resistance 1, interferon-inducible protein p78) gene has been implicated in the resistance to a wide range of RNA viruses including influenza A in several species such as Sus scrofa...
  34. pmc miRNA-129-5p suppresses cell proliferation and invasion in lung cancer by targeting microspherule protein 1, E-cadherin and vimentin
    Yongzhou Zhang
    Department of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, Henan 475001, P R China
    Oncol Lett 12:5163-5169. 2016
    ..Bioinformatics analysis suggested three cancer-related miR-129-5p target genes: Microspherule protein 1 (MCRS1), E-cadherin and vimentin...
  35. ncbi Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain
    L Jacob
    Cell 50:215-25. 1987
    ..Thus the gene encodes two putative proteins of 1161 and 708 amino acids, p127 and p78, respectively, differing at their C termini...
  36. ncbi Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis
    Zivana Tezak
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    J Immunol 168:4154-63. 2002
    ..In particular, increased expression of IFN-alphabeta-inducible genes 6-16, myxovirus resistance protein p78, latent cytosolic transcription factor, LMP2, and TAP1 was observed...
  37. ncbi Structural features of the glycogen branching enzyme encoding genes from aspergilli
    Prasetyawan Sasangka
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya shi, Aichi 464 8601, Japan
    Microbiol Res 157:337-44. 2002
    A maltose binding protein, p78, was purified to homogeneity from Aspergillus nidulans by a single column chromatography step on cross-linked amylose...
  38. pmc Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor
    Koichi Okumura
    Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 102:2703-6. 2005
    ..report that the PTEN C-terminal domain physically interacts with the forkhead-associated domain of the oncogenic MSP58 protein and that this interaction requires PTEN Thr-366...
  39. ncbi Characterization of ORF2 and its encoded protein of the Helicoverpa armigera nucleopolyhedrovirus
    Yingchao Nie
    State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China
    Virus Res 116:129-35. 2006
    ..nucleopolyhedrovirus (HaSNPV), a conserved gene in most baculoviruses from lepidopteran insects such as p78/83 of the Autographa californica MNPV, was characterized. It is 1,242 bp long and potentially encodes a 45.9 kDa...
  40. ncbi Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein
    Erin D Goley
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 314:464-7. 2006
    ..by translocating the host actin-nucleating Arp2/3 complex into the nucleus, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome protein (WASP)-like protein...
  41. doi Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups
    Annamaria Tonazzi
    Department of Biosciences, Biotechnology and Pharmacological Sciences, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
    Biochim Biophys Acta 1817:697-704. 2012
    ..According to the homology model of CAC in cytosolic opened conformation (c-state), L14, G17, G21, V25, P78, V82, M85, C89, F93, A276, A279, C283, F287 are located in the 1st (H1), 2nd (H2) and 6th (H6) transmembrane α-..
  42. pmc 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway
    Che Chia Hsu
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan
    J Biol Chem 287:22533-48. 2012
    The nucleolar 58-kDa microspherule protein (MSP58) protein is a candidate oncogene implicated in modulating cellular proliferation and malignant transformation...
  43. doi Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation
    Mafei Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    FEBS Lett 586:1678-86. 2012
    Microspherule protein 2 (MCRS2) has been reported to associate with the cellular function of telomerase inhibition, transcriptional regulation and cellular transformation. Here, we report a novel function of MCRS2 in ASK1 pathway...
  44. pmc Expression of MSP58 in human colorectal cancer and its correlation with prognosis
    Hai Shi
    State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, Shanxi, People s Republic of China
    Med Oncol 29:3136-42. 2012
    We had reported that MSP58 regulates colorectal cancer cell proliferation, development, and apoptosis, by the cyclin D1-cyclin-dependent kinase 4-p21 pathway...
  45. pmc Molecular beacon aptamers for direct and universal quantitation of recombinant proteins from cell lysates
    Xiaohong Tan
    Molecular Science and Biomedicine Laboratory, College of Biology, Hunan University, Changsha, 410082, P R China
    Anal Chem 84:8272-6. 2012
    ..coli cell lysate. The amount of expressed P78-His was determined to be 1.49 μg from the 20 μg cell lysate proteins...
  46. doi Downregulation of MSP58 suppresses cell proliferation in neuroblastoma cell lines
    Lin Wu
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Xi an, Shaanxi, China
    Neuroreport 23:932-6. 2012
    b>MSP58, a novel oncogene, shows transforming activity in mouse embryonic fibroblasts. However, the oncogenic role of MSP58 in tumor cells has not been fully characterized...
  47. pmc Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice
    Yanling Liu
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States of America
    Mol Med 18:1387-401. 2012
    ..The antiangiogenic PEDF60-77 (P60) and neuroprotective PEDF78-121 (P78) derivatives were applied to Ins2(Akita) mouse eyes once a week for 15 wks at the onset of hyperglycemia...
  48. pmc The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression
    Mario Benavides
    Department of Biological Sciences, The City University of New York, New York, NY 10065, USA
    Biochim Biophys Acta 1833:21-32. 2013
    Microspherule protein Msp58 (or MCRS1) plays a role in numerous cellular processes including transcriptional regulation and cell proliferation...
  49. ncbi [Cloning and functional research of Arp2/3-P40/ARPC1 subunit of Sf9 cells]
    Shi Li Han
    Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China
    Bing Du Xue Bao 28:601-8. 2012
    The baculovirus-induced actin polymerization is mainly associated with the virus nucleocapsid protein P78/83, which is homologous with WASP proteins that can activate Arp2/3 complex and induce the actin polymerization...
  50. pmc Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats
    Martin Marek
    Laboratory of Virology, Wageningen University, Wageningen, The Netherlands
    J Virol 87:8465-80. 2013
    ..specifically recognizes these GGN-rich islands, which at the same time encode crucial proline-rich domains in p78/83, an essential gene adjacent to the polyhedrin gene in the AcMNPV genome...
  51. doi Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE
    Pauli Kallio
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    Biochemistry 52:4507-16. 2013
    ..results highlight the importance of a hairpin-β motif near the dimer interface, with two nonconserved residues, P78 and I79 (corresponding to Q89 and F90, respectively, in JadH), and invariant residue H73 playing key roles...
  52. pmc Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury
    Alaa S Awad
    Associate Professor of Medicine, and Cellular and Molecular Physiology, Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, P O Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F891-900. 2013
    ..We hypothesize that a PEDF fragment (P78-PEDF) confers kidney protection in diabetic nephropathy (DN)...
  53. doi Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients
    Wei Lin
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Med Oncol 30:677. 2013
    ..The 58-kD microspherule protein (MSP58) is an evolutionarily conserved nuclear protein and plays an important role in the regulation of cell ..
  54. ncbi Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins
    M Muller
    Department of Molecular Animal Breeding, Munich, FRG
    J Interferon Res 12:119-29. 1992
    ..5%. The porcine Mx1 polypeptide is most closely related to human MxA (p78), murine Mx2, rat Mx2, and rat Mx3 proteins...
  55. ncbi The Helminthosporium victoriae 190S mycovirus has two forms distinguishable by capsid protein composition and phosphorylation state
    S A Ghabrial
    Department of Plant Pathology, University of Kentucky, Lexington 40546
    Virology 188:657-65. 1992
    ..190S-1) contained p88 and p83 as the major capsid proteins; the faster component (190S-2) contained p88 and p78. Previous peptide-mapping studies have shown the three capsid proteins to be closely related...
  56. pmc Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter
    M A Horisberger
    Pharmaceuticals Research, Ciba Geigy Ltd, Basel, Switzerland
    J Virol 64:1171-81. 1990
    The human protein p78 is induced and accumulated in cells treated with type I interferon or with some viruses. It is the human homolog of the mouse Mx protein involved in resistance to influenza virus...
  57. ncbi cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene
    M A Horisberger
    Pharmaceuticals Research, Ciba Geigy Ltd, Basle, Switzerland
    Somat Cell Mol Genet 14:123-31. 1988
    Recently we have purified to homogeneity and characterized an interferon-induced human protein (p78 protein) which is the equivalent of the interferon-induced murine Mx protein responsible for a specific antiviral state against influenza ..
  58. ncbi Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q
    T E Broad
    Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
    Mamm Genome 6:202-5. 1995
    ..The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B)...
  59. ncbi Biogenesis of MHC class I antigens: involvement of multiple chaperone molecules
    B Kahn-Perles
    Centre d immunologie de Marseille Luminy, France
    Eur J Cell Biol 64:176-85. 1994
    ..HLA-Cw3 heavy chains (Cw3 alpha) specifically associate with three major long-lived proteins denoted p105, p88 and p78, according to their size. These proteins display different kinetics of interaction...
  60. ncbi Expression, assembly, and proteolytic processing of Helminthosporium victoriae 190S totivirus capsid protein in insect cells
    S Huang
    Department of Plant Pathology, University of Kentucky, Lexington 40546 0091, USA
    Virology 234:130-7. 1997
    ..encoded by a single gene, it is composed of two major closely related polypeptides, either p88 and p83 or p88 and p78. Whereas p88 and p83 are phosphoproteins, p78 is nonphosphorylated...
  61. pmc Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway
    E C Davis
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 140:295-303. 1998
    ..cross-linking and analysis by SDS-PAGE showed the presence of two proteins of approximately 74 kD (p74) and 78 kD (p78) that coimmunoprecipitated with tropoelastin...
  62. ncbi Identification of a novel 81-kDa component of the Xenopus origin recognition complex
    P B Carpenter
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 273:24891-7. 1998
    ..Xorc2 (p63) is specifically associated with Xorc1 (p115) and up to four additional polypeptides (p81, p78, p45, and p40)...
  63. ncbi Assembly of the Hv190S totivirus capsid is independent of posttranslational modification of the capsid protein
    A I Soldevila
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, 40546 0091, USA
    Virology 251:327-33. 1998
    ..of Hv190SV, even though encoded by a single gene, contains three closely related capsid polypeptides: p88, p83, and p78. p88 and p83 are phosphorylated, whereas p78, which is derived from p88 via proteolytic processing at the C ..
  64. pmc A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection
    R Bruni
    The Marjorie B Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois 60637, USA
    J Virol 73:3810-7. 1999
    ..but not ICP22 lacking the carboxyl-terminal 40 amino acids, whereas the previously identified cellular protein p78 (R. Bruni and B. Roizman, J. Virol. 72:8525-8531, 1998) bound all forms of ICP22...
  65. ncbi Erythropoietin improves signaling through tyrosine phosphorylation in platelets from uremic patients
    M Diaz-Ricart
    Servicios de Hemoterapia Hemostasia, Hospital Clinic, Universitat de Barcelona, Spain
    Thromb Haemost 82:1312-7. 1999
    ..After thrombin activation, proteins p120, p85, p78, p75, pp62, pp60, p59, p58, p56, p54 and p52 associated with the Triton-insoluble cytoskeletal fraction appeared ..
  66. ncbi Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region
    R Tazi-Ahnini
    Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, UK
    Hum Genet 106:639-45. 2000
    ..MX1 is the gene encoding the interferon-induced p78 protein (MxA)...
  67. ncbi Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression
    M H Vaarala
    Biocenter Oulu, World Health Organization Collaborating Centre for Research on Reproductive Health, Finland
    Lab Invest 80:1259-68. 2000
    ..Tissue-type plasminogen activator, interferon-inducible protein p78 (MxB), an EST similar to galectin-1, follistatin, fatty acid-binding protein 5, EST AA609749, annexin I, the ..
  68. ncbi Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation
    Y Akimoto
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham Station, Alabama 35294, USA
    Arch Biochem Biophys 389:166-75. 2001
    ..Hyperglycemic RASM cells also display a relative increase in OGTase's p78 subunit and an overall increase protein and activity for OGTase...
  69. ncbi Detection of Lawsonia intracellularis in diagnostic specimens by one-step PCR
    D K Suh
    Research Institute of Public Health and Environment, Taegu 706 100, Korea
    J Vet Sci 1:33-7. 2000
    ..intracellularis. Primers were designed based on the p78 DNA clone of L. intracellularis...
  70. ncbi Occurrence of Lawsonia Intracellularis and Brachyspira spp. infection in swine suffering from diarrhoea
    J Pławińska
    Department of Preclinical Sciences, Faculty of Veterinary Medicine, Agricultural University, Ciszewskiego 8, 02 786 Warsaw, Poland
    Pol J Vet Sci 7:203-6. 2004
    ..The molecular techniques such as PCR and nested PCR were employed to detect the presence of p78 fragment of genomic DNA specific for Lawsonia intracellularis as well as fragment of tlyA gene specific for ..
  71. ncbi Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins
    A V Ivanova
    Laboratory of Immunobiology, Basic Research Program, SAIC Frederick Inc, NCI Frederick, MD 21702, USA
    Cell Mol Life Sci 62:471-84. 2005
    ..Here we report on STRA13 interaction with the cell cycle-associated transcription factor MSP58. We demonstrated that the basic domain of STRA13 and the FHA domain of MSP58 are essential for this association...
  72. ncbi Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification
    Sonia Eladad
    Laboratory of Cancer Suspectibility, Department of Medicine, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Mol Genet 14:1351-65. 2005
    ..These results constitute evidence that BLM is a DNA damage sensor that signals the formation of DDI, and they establish SUMO modification as a negative regulator of BLM's signaling function...
  73. ncbi Does recombinant adeno-associated virus-vectored proximal region of mouse rhodopsin promoter support only rod-type specific expression in vivo?
    Lyudmyla G Glushakova
    Department of Ophthalmology, University of Florida, Gainesville, FL, USA
    Mol Vis 12:298-309. 2006
    ..Here, we evaluated whether the presence of certain cis-elements in this proximal promoter, such as the rod-specific, neural retina leucine zipper protein (NRL) response element (NRE), can render it a driver of rod-specific expression...
  74. ncbi Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain
    Pia März
    Institute of Physiology, Pestalozzistr 20, University of Basel, CH 4056 Basel, Switzerland
    J Biol Chem 281:20263-70. 2006
    ..In PC12 cells and pancreas, this association is competed by the shorter OGT p78 splice form, which is down-regulated in brain...
  75. ncbi The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner
    Nicoletta Casartelli
    Division of Immunology and Infectious Disease, Children s Hospital Bambino Gesu, Piazza S Onofrio 4, 00165 Rome, Italy
    J Gen Virol 87:2291-6. 2006
    ..type 1 (HIV-1) that contains a proline-rich motif consisting of four conserved prolines: Pro69 (P69), P72, P75 and P78. P72 and P75 were shown to bind Src homology domains 3 (SH3) and have been implicated in many biological functions ..
  76. pmc Adeno-associated virus type 2 p5 promoter: a rep-regulated DNA switch element functioning in transcription, replication, and site-specific integration
    Mary Murphy
    Weill Medical College of Cornell University, Hearst Research Foundation, Department of Microbiology and Immunology, Box 62, 1300 York Ave, New York, NY 10021, USA
    J Virol 81:3721-30. 2007
    The large Rep proteins, p68 and p78, function as master controllers of the adeno-associated virus type 2 (AAV2) life cycle, involved in transcriptional control, in latency, in rescue, and in viral DNA replication...
  77. pmc Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100
    Fei Deng
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People s Republic of China
    J Virol 81:9377-85. 2007
    ..These include polyhedrin, P78/83, P49, ODV-E18, ODV-EC27, ODV-E56, P74, LEF-3, HA66 (AC66), DNA polymerase, GP41, VP39, P33, ODV-E25, helicase, ..
  78. ncbi YY1 functions with INO80 to activate transcription
    Yong Cai
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Struct Mol Biol 14:872-4. 2007
    ..Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters...
  79. ncbi Internalization and intracellular retention of CD4 are two separate functions of the human immunodeficiency virus type 1 Nef protein
    Giorgia Giolo
    Division of Immunology and Infectious Disease, Children s Hospital Bambino Gesu, 00165 Rome, Italy
    J Gen Virol 88:3133-8. 2007
    ..By means of in vivo-selected mutations, we show that L37, P78 and E177 residues of Nef are required for its effect on CD4 internalization and recycling but dispensable for Nef-..
  80. pmc Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit
    Colleen M Noviello
    University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Virol 82:1249-58. 2008
    ..canonical leucine-based AP-binding motif in Nef; it required residue Y320 in the MHC-I CD and residues E62-65 and P78 in Nef, and it involved the mu but not the gamma/sigma subunits of AP-1...
  81. ncbi [Cloning and analysis of the Vibrio harveyi dam gene]
    Hua Lei Wang
    Ocean University of China, Qingdao 266003, China
    Wei Sheng Wu Xue Bao 47:855-9. 2007
    ..harveyi dam structural gene was cloned in three fragments of different length: 78bp, 112 bp and 477bp (named P78, P112, and P477, respectively) and tested for promoter activity...
  82. ncbi [Study on the body mass index reference norm for defining overweight and obesity in school-age children and adolecents with Uygur and Han ethnic backgrounds in Urumqi]
    Jiang Hong Dai
    Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medical University, Urumqi 830054, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:635-41. 2007
    ..To construct and compare the body mass index (BMI) cutoff points for defining overweight and obesity in school-age children and youths with Uygur and Han ethnic backgrounds in Xinjiang, China...
  83. pmc Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats
    Jerry P Pian
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, SP30 1501, La Jolla, CA 92037, USA
    Brain Res 1194:28-36. 2008
    ..to evaluate the acute effects of alcohol on cortical electroencephalogram (EEG) in adolescent (P36) and adult (P78) Wistar rats. Five minutes of EEG was recorded after administration of 0, 0.75 or 1.5 g/kg alcohol...
  84. doi Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model
    Luis F Pacios
    Unidad de Química y Bioquímica, Departamento de Biotecnologia, E T S Ingenieros de Montes, Madrid, Spain
    Mol Immunol 45:2269-76. 2008
    ..Peptide alignments revealed consensus sequences for each pool: L37 R39 T40 P42 D43 R44 A46 P70 S76 P78 Y79 for OAS-IgE, and N35 N36 L37 R39 T40 D43 A46 S76 I77 P78 for systemic-IgE...
  85. ncbi [Determination of nicotinamide in formula milk powder using liquid chromatography-isotope dilution mass spectrometry]
    Ting Huang
    Chemical Metrology and Analytical Science Division, National Institute of Metrology, Beijing 100013, China
    Se Pu 25:922-5. 2007
    ..This method was used to perform international comparison for CCQM-P78, and the result was consistent with that of international laboratories.
  86. pmc Autographa californica multiple nucleopolyhedrovirus nucleocapsid protein BV/ODV-C42 mediates the nuclear entry of P78/83
    Yun Wang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People s Republic of China
    J Virol 82:4554-61. 2008
    ..C42 is demonstrated to be essential for AcMNPV propagation and can bind to nucleocapsid protein P78/83, a viral activator for the actin-related protein 2/3 (ARP2/3) complex to initiate nuclear actin polymerization, ..
  87. doi TOJ3, a v-jun target with intrinsic oncogenic potential, is directly regulated by Jun via a novel AP-1 binding motif
    Antonios I Karagiannidis
    Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
    Virology 378:371-6. 2008
    ..Transforming activity has also been demonstrated for MSP58, the human homolog of TOJ3, and oncogenic cell transformation by MSP58 is specifically inhibited by the tumor ..
  88. pmc Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioning
    Roxann C Harvey
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, Boston, MA, 02215, USA
    Psychopharmacology (Berl) 206:61-71. 2009
    ..No deficits in stimulus-reward learning are produced by cocaine exposure initiated during adolescence...
  89. pmc An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex
    Rajendra Kumar Singh
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e8364. 2009
    ..We previously proposed that Nef allows the MHC-I CD to bind the mu subunit of AP-1 (micro1) as if it contained a Yxxphimotif...
  90. pmc MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
    Girdhar G Sharma
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Mol Cell Biol 30:3582-95. 2010
    ..We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair...
  91. pmc The putative pocket protein binding site of Autographa californica nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin polymerization
    Kun Li
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    J Virol 84:7857-68. 2010
    ..multiple nucleopolyhedrovirus (AcMNPV) BV/ODV-C42 (C42) is involved in nuclear actin polymerization by recruiting P78/83, an AcMNPV orf9-encoded N-WASP homology protein that is capable of activating an actin-related-protein 2/3 (Arp2/..
  92. doi The nonspecific lethal complex is a transcriptional regulator in Drosophila
    Sunil Jayaramaiah Raja
    Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mol Cell 38:827-41. 2010
    Here, we report the biochemical characterization of the nonspecific lethal (NSL) complex (NSL1, NSL2, NSL3, MCRS2, MBD-R2, and WDS) that associates with the histone acetyltransferase MOF in both Drosophila and mammals...
  93. pmc Actin-based motility drives baculovirus transit to the nucleus and cell surface
    Taro Ohkawa
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 190:187-95. 2010
    ..Motility requires the viral P78/83 capsid protein and the host Arp2/3 complex...
  94. pmc Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription
    Ditte Skovaa Andersen
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell Biol 30:4744-55. 2010
    Drosophila MCRS2 (dMCRS2; MCRS2/MSP58 and its splice variant MCRS1/p78 in humans) belongs to a family of forkhead-associated (FHA) domain proteins...
  95. doi Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development
    Danielle S Counotte
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Eur J Neurosci 32:1452-60. 2010
    ..the molecular composition of a synaptic membrane fraction from adolescent postnatal day (P)34 and P44 and adult (P78) rat medial prefrontal cortex...
  96. doi Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male rats
    Iva Z Mathews
    Department of Psychology, Brock University, St Catharines, ON, Canada L2S3A1
    Pharmacol Biochem Behav 97:640-6. 2011
    ..Male rats were pre-treated with 0.5mg/kg amphetamine or saline on either postnatal days (P) 31 and P33 or P76 and P78, and locomotor activity was measured for 1h...
  97. pmc Mapping signals that are important for nuclear and nucleolar localization in MCRS2
    Chung Wen Kuo
    Department of Microbiology and Immunology, Chang Gung University, Kwei Shan, Taoyuan, 33302, Taiwan
    Mol Cells 31:547-52. 2011
    b>MCRS2 is an oncoprotein that is sequestered in the nucleolus. When in the nucleolus, it promotes the transcription of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function...
  98. pmc Neonatal exposure to lipopolysaccharide enhances methamphetamine-induced reinstated behavioral sensitization in adult rats
    Lu Tai Tien
    School of Medicine, Fu Jen Catholic University, Xinzhuang Dist, New Taipei City 24205, Taiwan
    Behav Brain Res 224:166-73. 2011
    ..Ninety-six hours after the 5th treatment with METH or saline (P78), animals received a single dose of 0.5mg/kg METH (s.c.) or saline...
  99. pmc Neonatal exposure of rats to antidepressants affects behavioral reactions to novelty and social interactions in a manner analogous to autistic spectrum disorders
    Federico Rodriguez-Porcel
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Anat Rec (Hoboken) 294:1726-35. 2011
    ..Later, rats were tested 2× for response to a novel object (P39), and to a novel conspecific (P78, P101)...
  100. pmc A new cap for kinetochore fibre minus ends
    Sabine Petry
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nat Cell Biol 13:1389-91. 2011
    ..b>Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres ..

Research Grants3

  1. SPINDLE ASSEMBLY CHECKPOINT IN VERTEBRATES AND YEAST
    Rey Huei Chen; Fiscal Year: 2003
    ..approached biochemically in frog egg extracts using the key checkpoint component XMAD2 and its interacting protein p78 as the probes. The specific aims are: (1) Characterization of p78 and its interaction with XMAD2...
  2. GLYCOCONJUGATES IN DEVELOPMENT AND IMMUNITY
    Gerald Hart; Fiscal Year: 2007
    ..These studies are fundamentally important to the regulation of transcription and signal transduction processes important to virtually all aspects of development and disease. ..
  3. O-GlcNAc:Developing New Tool for Assessment of Glycemia
    Gerald Hart; Fiscal Year: 2008
    ..The project also represents a new inter-disciplinary, inter-departmental basic science-clinical research collaboration between Biological Chemistry and The Department of Medicine. ..