MCP-1

Summary

Gene Symbol: MCP-1
Description: C-C motif chemokine ligand 2
Alias: GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine 2, chemokine (C-C motif) ligand 2, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, monocyte chemotactic protein 1, monocyte secretory protein JE, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je), small inducible cytokine subfamily A (Cys-Cys), member 2, small-inducible cytokine A2
Species: human

Top Publications

  1. pmc Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice
    Bridgette D Semple
    National Trauma Research Institute, Alfred Hospital, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:769-82. 2010
  2. pmc IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:4479-87. 2010
  3. ncbi MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 Da Shue Road, Tainan 701, Taiwan
    J Gen Virol 87:3623-30. 2006
  4. ncbi NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene
    A Ueda
    First Department of Internal Medicine, Yokohama City University School of Medicine, Japan
    J Immunol 153:2052-63. 1994
  5. doi Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations
    Luca Valenti
    Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy
    Arterioscler Thromb Vasc Biol 31:683-90. 2011
  6. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
  7. doi Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
    Massimo Zollo
    Centro di Ingegneria Genetica, Biotecnologie Avanzate CEINGE, Via Gaetano Salvatore 486, 80145, Naples, Italy
    Clin Exp Metastasis 29:585-601. 2012
  8. ncbi Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients
    Abdolreza Rezaie-Majd
    Clinic of Internal Medicine II, Department of Angiology, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:1194-9. 2002
  9. ncbi MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Hematology 7:113-7. 2002
  10. ncbi MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration
    Jing Ma
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 109:987-94. 2007

Research Grants

  1. Val S Goodfellow; Fiscal Year: 2014
  2. Michael T Bailey; Fiscal Year: 2016
  3. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
  4. The Role of Microglia in Prolonged Anxiety-like Behavior following Social Stress
    Eric S Wohleb; Fiscal Year: 2013
  5. Ronald G Collman; Fiscal Year: 2015
  6. Andrew H Miller; Fiscal Year: 2014
  7. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
  8. Eric G Pamer; Fiscal Year: 2016
  9. George S Deepe; Fiscal Year: 2014
  10. Heather L Machado; Fiscal Year: 2015

Detail Information

Publications357 found, 100 shown here

  1. pmc Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice
    Bridgette D Semple
    National Trauma Research Institute, Alfred Hospital, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:769-82. 2010
    ..Our findings confirm the significant role of CCL2 in mediating post-traumatic secondary brain damage...
  2. pmc IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:4479-87. 2010
    ....
  3. ncbi MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 Da Shue Road, Tainan 701, Taiwan
    J Gen Virol 87:3623-30. 2006
    ....
  4. ncbi NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene
    A Ueda
    First Department of Internal Medicine, Yokohama City University School of Medicine, Japan
    J Immunol 153:2052-63. 1994
    ....
  5. doi Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations
    Luca Valenti
    Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy
    Arterioscler Thromb Vasc Biol 31:683-90. 2011
    ....
  6. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    ..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course...
  7. doi Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
    Massimo Zollo
    Centro di Ingegneria Genetica, Biotecnologie Avanzate CEINGE, Via Gaetano Salvatore 486, 80145, Naples, Italy
    Clin Exp Metastasis 29:585-601. 2012
    ....
  8. ncbi Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients
    Abdolreza Rezaie-Majd
    Clinic of Internal Medicine II, Department of Angiology, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:1194-9. 2002
    ..The anti-inflammatory effects of statins have recently been implicated in the clinical benefit that can be obtained in the treatment of atherosclerosis. Little is known about the mechanisms by which statins counteract inflammation...
  9. ncbi MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Hematology 7:113-7. 2002
    ..05). These data indicate that hMSCs are targeted by inflammatory chemotactic agents and cytokines and that ischemic brain attracts hMSCs...
  10. ncbi MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration
    Jing Ma
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 109:987-94. 2007
    ..Taken together, our findings suggest that MCP-1 mediates TGF-beta-stimulated angiogenesis by enhancing migration of mural cells toward ECs and thus promoting the maturation of new blood vessels...
  11. doi Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells
    Maylis Dagouassat
    INSERM U698, Bioingénierie cardiovasculaire, Universite Paris 13, Bobigny, France
    Int J Cancer 126:1095-108. 2010
    ....
  12. pmc Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2
    Eric Gaudreault
    Viral Immunology Laboratory, CHUL Research Center CHUQ, 2705 Boul Laurier, Room T 1 49, Quebec, QC, Canada G1V 4G2
    J Virol 81:8016-24. 2007
    ..In addition, EBV infection of primary human monocytes induced the release of MCP-1 (monocyte chemotactic protein 1), and the use of small interfering RNA targeting TLR2 significantly reduced such a chemokine response ..
  13. pmc Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells
    Ibolya E Andras
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg, 900 S Limestone, Lexington, KY 40536, USA
    Mol Pharmacol 73:1424-33. 2008
    ..In addition, simvastatin may provide a beneficial influence by reducing these effects at the BBB level...
  14. pmc CD16+ monocytes in breast cancer patients: expanded by monocyte chemoattractant protein-1 and may be useful for early diagnosis
    A L Feng
    Institute of Basic Medical Sciences Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Clin Exp Immunol 164:57-65. 2011
    ..exposed to Michigan Cancer Foundation (MCF)-7 cells-conditioned medium (MCF-CM) or, separately, to monocyte chemotactic protein 1 (MCP-1)...
  15. pmc MCP1 haplotypes associated with protection from pulmonary tuberculosis
    Christopher D Intemann
    Bernhard Nocht Institute for Tropical Medicine, Dept Molecular Medicine, Hamburg, Germany
    BMC Genet 12:34. 2011
    The monocyte chemoattractant protein 1 (MCP-1) is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions...
  16. doi Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
    Retina 31:1951-7. 2011
    ..To investigate whether concurrent hypertension affects vitreous cytokine levels in diabetic retinopathy...
  17. pmc Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man
    Andrew J Boyle
    Department of Medicine, Division of Cardiology, University of California San Francisco, USA
    J Transl Med 9:150. 2011
    ..It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium...
  18. pmc CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
    Karin Westin
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    PLoS ONE 7:e30525. 2012
    ..Moreover, CCR2-related signaling pathways might be new therapeutic targets for therapies aiming at slowing down the disease progression rate of AD...
  19. ncbi NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy
    Sergio Mezzano
    Department of Nephrology, School of Medicine, Universidad Austral Bueras 1003 2 P, PO Box 8 D, Valdivia, Chile
    Nephrol Dial Transplant 19:2505-12. 2004
    ..It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy (DN). We examined the hypothesis that NF-kappaB could be an indicator of renal damage progression in DN...
  20. pmc Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes
    O Kutsch
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    J Virol 74:9214-21. 2000
    ..In contrast, Tat-mediated IP-10 mRNA induction was suppressed by SB202190 but not by the MEK1/2 inhibitor UO126. These findings indicate that MAPKs play a major role in Tat(72aa)-mediated chemokine induction in astrocytes...
  21. ncbi The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways
    Ladislav Burysek
    Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, D 89081 Ulm, Germany
    J Biol Chem 277:33509-17. 2002
    ..Taken together, our data demonstrate a novel function of the serine protease plasmin in a proinflammatory signaling network...
  22. pmc Increased MCP-1 and microglia in various regions of the human alcoholic brain
    Jun He
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Exp Neurol 210:349-58. 2008
    ..alcoholics obtained from the New South Wales Tissue Resource Center were used to study the cytokine, monocyte chemoattractant protein 1 (MCP-1,CCL2) and microglia markers in various brain regions...
  23. pmc Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections
    Andreas Oberbach
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e10882. 2010
    ....
  24. ncbi Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE
    T Yoshimura
    Laboratory of Immunobiology, National Cancer Institute, Frederick, MD 21701
    FEBS Lett 244:487-93. 1989
    ..Among proteins with similar sequences, the coding regions of MCP-1 and mouse JE show 68% identity. This suggest that MCP-1 is the human homologue of the mouse competence gene JE...
  25. doi MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy
    G H Tesch
    Dept of Nephrology, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria 3168, Australia
    Am J Physiol Renal Physiol 294:F697-701. 2008
    ..These findings provide a strong rationale for developing specific therapies against MCP-1 and inflammation in diabetic nephropathy...
  26. ncbi Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-kappaB pathway
    Elisabetta Caselli
    Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy
    Blood 109:2718-26. 2007
    ..Following IKK activation, HHV-8 selectively triggered the production of high levels of monocyte chemoattractant protein 1 (MCP-1), whereas it did not affect the expression of other NF-kappaB-dependent proinflammatory ..
  27. doi Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis
    Wenxin Zheng
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 60:1957-65. 2009
    ..In this study, we investigated the role and molecular mechanism of OPN in the induction of 2 key chemokines, monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1beta (MIP-1beta), in RA.
  28. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  29. ncbi Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase
    Xi Lin Chen
    Athero Genics, Inc, 8995 Westside Parkway, Alpharetta, GA 30004, USA
    Am J Physiol Heart Circ Physiol 286:H1001-7. 2004
    ..These data suggest that ROS such as superoxide and H(2)O(2) derived from Rac1-activated NADPH oxidase mediate TNF-alpha-induced MCP-1 expression in endothelial cells...
  30. doi Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behçet's disease
    Shengping Hou
    First Affiliated Hospital, Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China
    Hum Immunol 71:79-82. 2010
    ..In conclusion, the present study suggests that the MCP-1 -2518 AA genotype seems to display a protective association with ocular BD, whereas the -2518 AG genotype might be a susceptible factor for ocular BD in the Chinese Han population...
  31. doi Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish type 2 diabetes patients with nephropathy
    M Karadeniz
    Department of Endocrinology and Metabolism Disease, Bornova, Ege University Medical School, Izmir 35100, Turkey
    Endocrine 37:513-7. 2010
    ..In conclusion, MCP-1 AA genotype and A allele may play a specific role(s) in determining diabetic susceptibility, but do not seem to be important in the clinical manifestations of DN...
  32. doi Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells
    Hsiao Ying Chiu
    Institute of Bioscience and Biotechnology, Center of Excellence for Marine Bioenvironment and Biotechnology CMBB, National Taiwan Ocean University, Keelung, Taiwan
    Cytokine 59:423-32. 2012
    ..Our findings suggest that this CCL2/CCR2 pathway is a potential candidate for the attenuation of bladder cancer metastases...
  33. doi Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare
    R G Singh
    Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, India
    Lupus 21:1214-8. 2012
    ..This study aimed to assess correlation of urinary monocytic chemoattractant protein-1 (UMCP-1) with severity of lupus nephritis and its role as predictor of outcome...
  34. doi MCP-1 in urine as biomarker of disease activity in Systemic Lupus Erythematosus
    Julia Barbado
    Autoimmunity Unit, Internal Medicine Service, Hospital Clínico Universitario de Valladolid SACYL, Ramon y Cajal 3, 47005 Valladolid, Spain
    Cytokine 60:583-6. 2012
    ..In conclusion, multiplex-based cytokine profiling in urine demonstrated the superiority of MCP-1 over a wide range of cytokines as biomarker of disease activity in SLE...
  35. doi Monocyte chemoattractant-1 as a urinary biomarker for the diagnosis of activity of lupus nephritis in Brazilian patients
    Renata Ferreira Rosa
    Department of Rheumatology, and the Department of Immunology, Servidor Público Estadual Hospital, Sao Paulo, Brazil
    J Rheumatol 39:1948-54. 2012
    ..Our aim was to assess urinary MCP-1 (uMCP-1) as a biomarker of renal activity in patients with SLE and to compare it to other disease activity markers, using the ELISA...
  36. doi Urinary MCP-1 and RBP: independent predictors of renal outcome in macroalbuminuric diabetic nephropathy
    S M Titan
    Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Diabetes Complications 26:546-53. 2012
    ..However, recent data suggest that albuminuria may fail as a biomarker in a subset of patients, and the search for novel markers is intense...
  37. ncbi Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1
    Eijiro Ohga
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Appl Physiol (1985) 94:179-84. 2003
    ..Treatment of OSAS using nCPAP can be, therefore, a potential approach to decrease risk of the progression of OSAS-associated disorders...
  38. ncbi MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission
    William S Modi
    SAIC Frederick and the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
    AIDS 17:2357-65. 2003
    ..An epidemiological analysis identified genetic variants influencing HIV-1 transmission and disease progression...
  39. pmc Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1
    Amy M Sutcliffe
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Br J Pharmacol 157:436-50. 2009
    ..We studied the effect of ET-1 on expression of the chemokine, monocyte chemotactic protein-1 (MCP-1), in primary cultures of human airway smooth muscle cells...
  40. ncbi Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis
    Ali Akoum
    Département d obstétrique gynécologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 77:989-94. 2002
    ..To assess spontaneous and stimulated secretion of monocyte chemotactic protein-1 (MCP-1) and macrophage migration inhibitory factor (MIF) by peritoneal macrophages in women with and without endometriosis...
  41. ncbi Cardiotrophin-1 induces monocyte chemoattractant protein-1 synthesis in human umbilical vein endothelial cells
    Michael Fritzenwanger
    Department of Internal Medicine I, Division of Cardiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07740 Jena, Germany
    Cytokine 33:46-51. 2006
    ..In CHF, CT-1 may be able to induce MCP-1 which might be responsible for progression of heart failure either by recruiting inflammatory cells within the myocardium or by a direct modulation of myocyte function...
  42. pmc Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors
    Rajesh Kumar
    Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi
    Immunology 130:193-201. 2010
    ..These data suggest that IL-8 is an effector immune-determinant in the progression of CL, whereas NO facilitates the parasite killing by macrophages via MCP-1-mediated stimulation...
  43. doi Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis
    Ziya Kaya
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Cardiovasc Res 91:116-23. 2011
    ..adeno-associated virus (AAV)-9-mediated cardiac expression of the anti-inflammatory mediators interleukin (IL)-10 and a dominant-negative inhibitor of monocyte chemoattractant protein-1 (MCP1-7ND) on prevention of autoimmune myocarditis.
  44. doi Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease
    Keiko Nishi
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Ren Fail 33:398-404. 2011
    ..Additionally, PTX3 might be a more sensitive marker for the association of CVD than hsCRP and TNFα in patients with advanced CKD...
  45. doi N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells
    Arun Kumar Nalla
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
    Exp Cell Res 317:2512-21. 2011
    ..Our data demonstrated that N-cadherin in prostate cancer cell mediates cell-cell adhesion and regulates MCP-1 expression via the PI3K/Akt signaling pathway...
  46. ncbi Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Thromb Haemost 89:149-60. 2003
    ....
  47. ncbi Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection
    M Sean Esplin
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Matern Fetal Neonatal Med 17:365-73. 2005
    ..This study was conducted to determine if preterm labor leading to preterm delivery and intra-amniotic infection (IAI) are associated with changes in the amniotic fluid concentrations of MCP-1...
  48. ncbi Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
    Marcus W Butler
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 281:34730-5. 2006
    ..These results suggest that inhibition by elafin of lipopolysaccharide-induced AP-1 and NF-kappaB activation occurs via an effect on the ubiquitin-proteasome pathway...
  49. ncbi Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells
    Akihide Tanimoto
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 283:4643-51. 2008
    ....
  50. pmc Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption
    Yao Yao
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794 8651, USA
    J Cell Sci 124:1486-95. 2011
    Previous studies have shown that plasmin cleaves monocyte chemoattractant protein 1 (MCP1; officially known as C-C motif chemokine 2, CCL2) at K104, and this cleavage enhances its chemotactic potency significantly...
  51. doi Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes
    Silvia Lorente-Cebrián
    Department of Medicine Huddinge, Lipid Laboratory, Karolinska Institutet, NVS, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Eur J Nutr 51:335-42. 2012
    ....
  52. doi CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS
    Maria Rosito
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Fisiologia e Farmacologia, Universita Sapienza, Rome, 00185 Italy
    J Neurosci 32:3154-63. 2012
    ....
  53. pmc CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation
    Hernan Roca
    Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 283:25057-73. 2008
    ..Altogether, these findings indicate that CCL2 protects prostate cancer PC3 cells from autophagic death via the phosphatidylinositol 3-kinase/Akt/survivin pathway and reveal survivin as a critical molecule in this survival mechanism...
  54. ncbi Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages
    Laura Fantuzzi
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 102:2334-7. 2003
    ..These results suggest that CCL2 may represent an autocrine factor important for enhancing virion production likely by affecting the macrophage cytoskeleton...
  55. ncbi CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:1098-106. 2006
    ..These data suggest that CCL2, but not other chemokines, plays a key role in infiltration of HIV-infected leukocytes into the CNS and the subsequent pathology characteristic of NeuroAIDS...
  56. doi Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis
    Kristina Eisinger
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Exp Mol Pathol 92:90-6. 2012
    ..Here, we analyzed whether synovial fibroblasts express chemerin and its receptor CMKLR1. Further, the role of chemerin in synovial fibroblast chemotaxis, proliferation, insulin response and release of inflammatory proteins was studied...
  57. ncbi High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthtritis
    A Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 27:22-7. 2009
    ..To evaluate serum levels of CXCL10 and CCL2 in a large series of PsA patients, and to relate chemokines levels to the clinical phenotype of these patients...
  58. ncbi Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy
    Tsukasa Morii
    Department of Geriatric Medicine, Akita University School of Medicine, 1 1 1 Hondo, Japan
    J Diabetes Complications 17:11-5. 2003
    ..Therefore, we conclude that heavy proteinuria itself may accelerate the progression of diabetic nephropathy by increasing the MCP-1 expression in renal tubuli...
  59. ncbi A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 125:1085-93. 2003
    ..In this study, we investigated the correlation of the functional -2518 MCP-1 promoter polymorphism with hepatic MCP-1 expression and the disease outcome in patients with HCV...
  60. ncbi Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle
    Henrike Sell
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf
    Endocrinology 147:2458-67. 2006
    ..Therefore, MCP-1 may represent a molecular link in the negative cross-talk between adipose tissue and skeletal muscle assigning a completely novel important role to MCP-1 besides inflammation...
  61. pmc CCL2 is a potent regulator of prostate cancer cell migration and proliferation
    Robert D Loberg
    Department of Urology, University of Michigan Urology Center, Ann Arbor, MI 48109 0946, USA
    Neoplasia 8:578-86. 2006
    ..b>Monocyte chemoattractant protein 1 (CCL2) is a member of the CC chemokine family and is known to promote monocyte chemotaxis to sites ..
  62. ncbi MCP-1 Promoter Polymorphism at 2518 is associated with metastasis of nasopharyngeal carcinoma after treatment
    Ka Po Tse
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    Clin Cancer Res 13:6320-6. 2007
    ..We herein examined whether the single nucleotide polymorphism (SNP) at -2518 of the MCP-1 gene promoter region influences clinical outcomes among nasopharyngeal carcinoma (NPC) patients...
  63. ncbi HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1
    Elena Marini
    Department of Applied and Experimental Medicine, Section of Microbiology, University of Brescia, Brescia, Italy
    Cell Microbiol 10:655-66. 2008
    ..Overall our results suggest that p17 may play a critical role in the monocyte-mediated inflammatory processes, which are suspected to be major precipitating events in AIDS-defining diseases...
  64. doi Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for cardiovascular disease in hemodialyzed patients
    Monika Buraczynska
    Department of Nephrology, Laboratory for DNA Analysis and Molecular Diagnostics, Medical University of Lublin, Dr K Jaczewskiego 8, 20 954 Lublin, Poland
    Cytokine 44:361-5. 2008
    ..The aim of the present study was to assess the effect of this polymorphism on end-stage renal disease (ESRD) and cardiovascular disease (CVD) in hemodialyzed patients...
  65. pmc Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
    Pablo Saenz-Lopez
    Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    BMC Cancer 8:382. 2008
    ..The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk...
  66. pmc Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness
    Emin Alioglu
    Department of Cardiology, Central Hospital, Bayrakli, Izmir, Turkey
    Can J Cardiol 25:e1-5. 2009
    ..Common carotid intima-media thickness (cIMT) provides information on the severity of atherosclerosis...
  67. doi Monocyte chemoattractant protein-1 is associated with silent cerebral infarction in patients on haemodialysis
    E Uchida
    Department of Nephrology, Tsukumi Central Hospital, Oita, Japan
    Intern Med J 42:29-34. 2012
    ..We tested the hypothesis that increased MCP-1 concentration correlate with the occurrence of SCI in HD patients...
  68. ncbi [Expression of MCP-1 in the patients of chronic hepatitis B complicated with nonalcoholic fatty liver disease]
    Hong yan Shen
    Department of Clinical Laboratory, Xuzhou Central Hospital, Xuzhou, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28:975-8. 2012
    ..To investigate the expression level of monocyte chemoattractant protein-1 (MCP-1) in the liver of the patients with chronic hepatitis B (CHB) complicated with non-alcoholic fatty liver diseases (NAFLD)...
  69. pmc Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
    Mariana Murea
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1053, USA
    BMC Nephrol 13:148. 2012
    ..Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D)...
  70. ncbi Tumor necrosis factor-alfa and monocyte chemoattractant protein-1 gene polymorphisms in kidney transplant recipients
    Ebtesam M El-Gezawy
    Clinical Pathology Department, Assiut University, Assiut, Egypt
    Saudi J Kidney Dis Transpl 24:688-95. 2013
    ....
  71. ncbi COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells
    Seiji Futagami
    Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 1138603, Japan
    Prostaglandins Leukot Essent Fatty Acids 78:137-46. 2008
    ..Thus, MCP-1 had a synergistic effect on COX-2 and CCR2 protein expression in CD40L-stimulated HUVECs and thereby stimulated VEGF production in these cells...
  72. ncbi Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia
    G Mazur
    Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
    Neoplasma 54:285-9. 2007
    ..b>Monocyte chemoattractant protein 1 (MCP-1/CCL2) is the chemokine which could be involved in this process...
  73. ncbi Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies
    Ping Tsui
    Department of Molecular Discovery Technologies, Discovery Research, Centocor R and D Inc, 145 King of Prussia Road, Radnor, PA 19087, USA
    Hum Antibodies 16:117-25. 2007
    ..When tested in nude mice bearing human PANC-1 pancreatic tumor cells in Matrigel plugs, CCL2 and CCL12 antibodies potently inhibited tumor angiogenesis, indicating that both CCL2 and CCL12 may contribute to tumor angiogenesis...
  74. doi The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Hum Immunol 70:130-3. 2009
    ..Our results demonstrate that the functional variant -2518A>G of CCL2 is not implicated in the susceptibility or phenotype of SSc...
  75. doi CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 29:345-51. 2009
    ....
  76. ncbi [The relationship between monocyte chemoattractant protein-1 gene polymorphisms and the susceptibility to pulmonary tuberculosis]
    Ben fu Yang
    Department of Epidemiology, School of Public Health, Jining Medical College, Jining 272013, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:454-6. 2009
    ..To explore the possible relationship between the -2518 A/G single nucleotide polymorphisms in monocyte chemoattractant protein-1 (MCP-1) gene of Chinese Han population and the susceptibility to pulmonary tuberculosis...
  77. ncbi Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus
    E Simeoni
    Department of Cardiology, University Hospital, CHUV BH10, 1011, Lausanne, Switzerland
    Diabetologia 47:1574-80. 2004
    ..The A-2518G polymorphism in the distal regulatory region of MCP-1 may regulate gene expression. The aim of this study was to investigate the impact of this gene polymorphism on insulin resistance...
  78. ncbi Polymorphisms of chemokine and chemokine receptor genes in Type 1 diabetes mellitus and its complications
    B Yang
    Molecular Medicine Research Group, Peninsula Medical School, Universities of Exeter and Plymouth, Plymouth PL6 8BX, UK
    Cytokine 26:114-21. 2004
    ..6% vs. 28.8%, p < 0.02, Pc = ns). These results suggest that polymorphisms of the MCP-1, CCR2 and CCR5 genes may be associated with T1DM and its complications...
  79. ncbi The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells
    S Giunti
    Department of Internal Medicine, University of Turin, 14 Corso AM Dogliotti, 10126 Turin, Italy
    Kidney Int 69:856-63. 2006
    ..In conclusion, stretch and MCP-1 independently induce ICAM-1 expression in HMCs. Stretch-induced CCR2 downregulation may favour MCP-1 paracrine activity...
  80. doi Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells
    Lu Zhang
    Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
    J Cell Physiol 226:1694-701. 2011
    ..PC-PLC might be a potential target for therapy in inflammation associated-diseases such as atherosclerosis...
  81. ncbi Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population
    H J Park
    Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, Korea
    Scand J Rheumatol 36:299-306. 2007
    ....
  82. doi Visfatin stimulates production of monocyte chemotactic protein-1 and interleukin-6 in human vein umbilical endothelial cells
    S W Liu
    Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Horm Metab Res 41:281-6. 2009
    ..In summary, these results suggest that visfatin-induced MCP-1 and IL-6 production involve p38 MAPK, PI3K, and ERK 1/2 pathways in human umbilical vein endothelial cells as determined by inhibition with specific inhibitors...
  83. pmc Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators
    Renate B Schnabel
    National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702 5827, USA
    Blood 115:5289-99. 2010
    ..We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications...
  84. pmc Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients
    Pawan K Gupta
    Department of Neurology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh 160012, India
    J Neuroinflammation 8:47. 2011
    ..We measured these values in North Indian ALS patients, since these patients display considerably enhanced survival duration...
  85. ncbi Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells
    Selvajothi Abraham
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015 96, Room 203, Philadelphia, PA 19122, USA
    Virology 309:196-202. 2003
    ..These observations reveal a novel mechanism for Tat-mediated transcriptional activation via TGFbeta signaling pathway and provide evidence for regulation of MCP-1 gene transcription by this signaling pathway in human astrocytic cells...
  86. ncbi Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    Prostate 66:1311-8. 2006
    ..Increased MCP-1 serum levels in patients with various cancers were correlated with advanced stage. Here, we evaluated the role of MCP-1 on prostate cancer (CaP) cell proliferation and invasion...
  87. ncbi Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia
    P C A M Buijtels
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Int J Tuberc Lung Dis 12:1485-8. 2008
    ..The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5)...
  88. doi Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: implications for chemotaxis
    Helen Denney
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK
    Biochem Biophys Res Commun 382:341-7. 2009
    ..Monocytic cells exhibited a 2-fold reduction in migration to MMP-cleaved CCL2 variants, compared to intact CCL2...
  89. ncbi CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis
    K Alagarasu
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 130:444-50. 2009
    ..The aim of the present study was to find out whether chemokine, chemokine receptor and DC-SIGN gene polymorphisms were associated with susceptibility or resistance to HIV and HIV-TB in south India...
  90. ncbi Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness
    Yasuharu Tabara
    Department of Medical Genetics, Ehime University School of Medicine, Ehime, Japan
    Hypertens Res 26:677-83. 2003
    ..These findings indicate that plasma MCP-1 is associated with carotid atherosclerosis. Although -2518 SNP is associated with the plasma level of MCP-1, it was not directly associated with carotid atherosclerosis...
  91. ncbi Regulation of C-C motif chemokine ligand 2 and its receptor in human decidual stromal cells by pregnancy-associated hormones in early gestation
    Yin Yan He
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, People s Republic of China
    Hum Reprod 22:2733-42. 2007
    ..In the present study, the expression and regulation of chemokines and their receptors in decidua and DSCs were investigated...
  92. ncbi Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis
    M W Lawless
    Hepatology Research Division and Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Tissue Antigens 70:294-300. 2007
    ..Therefore, these findings offer a possible explanation in the variable clinical spectrum of pathogenesis in patients with HH through abnormalities of an imbalance in the immune states of patients with HH...
  93. pmc Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP
    Stephen H Page
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e22052. 2011
    ....
  94. ncbi Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients
    C Szalai
    Section of Molecular Immunology, Hungarian Academy of Sciences, Budapest, Hungary
    Atherosclerosis 158:233-9. 2001
    ..This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5Delta32 mutations are at reduced risk for severe CAD...
  95. pmc RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated with the outcome of hepatitis B virus infection: results from a large scale single ethnic population
    Jae Youn Cheong
    Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San 5 Wonchon Dong, Youngtong Gu, Suwon, Korea
    J Korean Med Sci 22:529-35. 2007
    ..In addition, no association of analyzed SNPs with HBV disease progression was found...
  96. pmc Tag SNP polymorphism of CCL2 and its role in clinical tuberculosis in Han Chinese pediatric population
    Wei Xing Feng
    Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing, China
    PLoS ONE 6:e14652. 2011
    ....
  97. pmc A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer
    Y Zhang
    Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 15:4851-5. 1995
    b>Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of proinflammatory cytokines, all of which share a high degree of amino acid sequence similarity...
  98. ncbi Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2
    S Hemmerich
    Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
    Biochemistry 38:13013-25. 1999
    ..This in turn orients the signaling residues (Y13 and the N-terminus) for productive interaction with the receptor...
  99. ncbi The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients
    Mi La Cho
    Rheumatism Research Center, Catholic Institutes of Medical Sciences, The Catholic University of Korea, 505 Banpo Dong, Seocho Ku, Seoul 137 701 South Korea
    Autoimmunity 37:77-80. 2004
    ..To compare the G vs. A variation at the MCP-1 promoter -2518 position among normal Koreans and Behcet patients, and to investigate possible association of this polymorphism with disease pathogenesis...
  100. pmc Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo
    Zhong Cai
    Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Neoplasia 11:228-36. 2009
    ..Both A549 and H1229 cells produced significantly higher amount of several cytokines including monocyte chemotactic protein 1 (MCP-1) and interleukin 8 (IL-8) compared with BEAS2B cells. These findings were confirmed by ELISA...
  101. pmc CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis
    Zahra Hasan
    The Aga Khan University, Karachi, Pakistan
    PLoS ONE 4:e8459. 2009
    ..tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity...

Research Grants79

  1. Val S Goodfellow; Fiscal Year: 2014
    ..Compounds showing efficacy in animal models will be profiled in in vitro safety and genotoxicity screens and dose ranging toxicity studies for selection as development compounds for late stage preclinical testing. ..
  2. Michael T Bailey; Fiscal Year: 2016
    ..reuteri colonizing the colon, and/or due to the production of immunomodulatory factor(s). This proposal will identify novel mechanism(s) that may lead to new therapeutic targets in the treatment of IBD. ..
  3. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
    ..abstract_text> ..
  4. The Role of Microglia in Prolonged Anxiety-like Behavior following Social Stress
    Eric S Wohleb; Fiscal Year: 2013
    ..In this application, RSD will be used to test the hypothesis that social stress primes microglia and recruits macrophages to the brain and these inflammatory changes contribute to prolonged anxiety-like behavior. ..
  5. Ronald G Collman; Fiscal Year: 2015
    ....
  6. Andrew H Miller; Fiscal Year: 2014
    ..abstract_text> ..
  7. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Finally, this project provides an opportunity for undergraduates at Boise State University to participate in biomedical research and gain an appreciation of the complex regulatory mechanisms that govern regeneration. ..
  8. Eric G Pamer; Fiscal Year: 2016
    ..Our laboratory has demonstrated that the CCR2 chemokine receptor and its ligands MCP1 and MCP3 are required for monocyte emigration from the bone marrow during Listeria monocytogenes infection...
  9. George S Deepe; Fiscal Year: 2014
    ..Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive. ..
  10. Heather L Machado; Fiscal Year: 2015
    ..abstract_text> ..
  11. C/EBPb Modulates Macrophages and Tumor-Initiating Cells During Preneoplastic Prog
    Heather L Machado; Fiscal Year: 2012
    ....
  12. Genital Anaerobes, Inflammation and HIV Risk;Rakai
    LANCE BRADLEY PRICE; Fiscal Year: 2012
    ..IL-1[unreadable], IL-8, IL-6, IL-12, RANTES, Monokine Induced by IFN? (MIG/CXCL9), Macrophage Chemotactic Protein (MCP1/CCL2), and Interferon Inducible Protein-10 (IP10/CXCL10)...
  13. Elizabeth J Kovacs; Fiscal Year: 2016
    ..Together these studies will provide new insights into the role of macrophages in inflamm-aging and may help determine whether different treatment strategies should be considered for young and aged burn patients. ..
  14. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
    ..The elucidation of the molecular mechanism(s) of action of genistein will provide clinically related strategies in protecting against atherosclerotic vascular disease. ..
  15. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
    ....
  16. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..To test our hypothesis, we will study the effects of diet-induced obesity on a number of factors related to inflammation in mice and also in human fat cells. ..
  17. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..This alarming observation raises the possibility that carbon nanotubes could pose a serious threat to human health and the environment. ..
  18. Chemokines in pathogenesis of Experimental Arthritis
    SEEMA SINGH AHUJA; Fiscal Year: 2010
    ..Thus information obtained from proposed studies which explore how CCR2 modulates arthritis will have significant impact on potential therapeutic strategies to treat this chronic deblitating disease. ..
  19. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2013
    ..The present project is thus focused on defining the essential role of SHP-1 in macrophage-mediated demyelinating disease. ..
  20. Harmeet Malhi; Fiscal Year: 2016
    ..Our results will yield mechanistic insights into regulation of macrophage lipoactivation and lipoapoptosis by individual UPR components, thus identifying potential molecules that can be targeted by therapeutic interventions. ..
  21. Edgar A Jaimes; Fiscal Year: 2014
    ..A better understanding of the mechanisms involved is critical in our efforts to develop novel strategies to prevent renal injury in hypertension, which would certainly result in improvements in morbidity and mortality in these patients. ..
  22. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..The results of this research will potentially lead us to develop novel, natural, and cost-effective agents to prevent and treat atherosclerosis caused by diabetes, a chronic disease that affects over 23 million Americans. ..
  23. Opioid Modulation of Inflammatory Monocyte Activity Involved in HIV Susceptibilit
    Thomas J Rogers; Fiscal Year: 2012
    ..We believe these studies will contribute significantly to our understanding of the molecular basis for the effects of opioids on the neuropathology associated with HIV infection. ..
  24. Sex Hormones and the Innate Immune Response to Influenza Infection
    DIONNE ROBINSON; Fiscal Year: 2012
    ..These data and our preliminary studies support the need for an in depth evaluation of the effects of sex steroid hormones on immune responses during influenza A infection. ..
  25. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..abstract_text> ..
  26. Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2012
    ....
  27. Madhavan P Nair; Fiscal Year: 2014
    ....
  28. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ....
  29. Chaim Putterman; Fiscal Year: 2014
    ..Determine the effect of TWEAK signaling in resident kidney cells, and particularly podocytes, in the development of LN, including albuminuria and glomerulosclerosis. ..
  30. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    ..fumigatus lung exposure and (3) To determine whether mediators associated with IL-17 induction (IL-21/IL-23), recruitment (SDF-1/MCP-1) and signaling (IL-22) pathways modulate lung host defense against A. fumigatus. ..
  31. Richard J Miller; Fiscal Year: 2015
    ....
  32. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ....
  33. Gadiparthi N Rao; Fiscal Year: 2016
    ....
  34. Role of Epithelial Chemokines in Kidney Injury-Molecule-1 Induced Renal Fibrosis
    Benjamin D Humphreys; Fiscal Year: 2010
    ..The proposed studies are therefore of great public health interest. ..
  35. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
  36. Mechanisms of MCP-1 in lung contusion with and without gastric aspiration
    Krishnan Raghavendran; Fiscal Year: 2013
    ....
  37. Chemokine-Cytokine Nexus in Fungal Immunity
    GEORGE DEEPE; Fiscal Year: 2009
    ..These findings contribute to the influence of the chemokine- cytokine network in microbial pathogenesis and evince a new role for CCL12. ..
  38. Binhua P Zhou; Fiscal Year: 2016
    ....
  39. Marc B Hershenson; Fiscal Year: 2014
    ..abstract_text> ..
  40. Dissecting the Role of HIV-1 Tat &Chemokine Axis in Subtype-Specificity of HAD
    Vinayaka R Prasad; Fiscal Year: 2012
    ..The current application provides evidence that such differences can be reproduced in small, laboratory animals and seeks to delineate the viral genes responsible for HAD. ..
  41. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ....
  42. Role of chemokines in diabetes
    Sergio A Lira; Fiscal Year: 2013
    ..We anticipate that blocking entry of inflammatory cells into the pancreas will prevent destruction of the insulin-producing cells;our work may thus prompt the generation of novel treatments for Type I diabetes. ..
  43. Alan Daugherty; Fiscal Year: 2015
    ..Is leukocyte accumulation in human ascending aortic aneurysmal tissue associated with MCP-1 and CCR2 expression? ..
  44. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..Understanding the signaling that control inflammation, proliferation, apoptosis, and angiogenesis may have therapeutic implication in treating vascular diseases. ..
  45. Guo Ping Shi; Fiscal Year: 2016
    ..This proposal tests the hypothesis that pro-inflammatory mast cells are important participants of obesity, and examines thoroughly whether we can manage body weight gain by regulating mast cell activity. ..
  46. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..These multiplexed assays will allow for the simultaneous measurement of different peptides in volumes as low as 25 5L of dialysate collected from the rat brain. ..
  47. Role of glial derived prostaglandins in pain due to surgery
    CHRISTOPHER MICHAEL PETERS; Fiscal Year: 2010
    ..goal of these studies is to gain a better understanding of spinal mechanisms that contribute to mechanical hypersensitivity following surgical incision in order to identify novel and more effective approaches to manage postoperative pain ..
  48. Alcohol-Chemokine Interactions and Neurotransmission
    Donna L Gruol; Fiscal Year: 2010
    ..Taken together, these studies will provide important new information that will significantly advance our understanding of the role of neuroimmune factors in alcoholism. ..
  49. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ....
  50. Rachana Shah; Fiscal Year: 2015
    ....
  51. AMANDA MICHELE GUTH; Fiscal Year: 2014
    ..This information will in turn be useful in designing therapeutic strategies to overcome the inherently immunosuppressive environment of tumors. ..
  52. MARIO TOMAS PHILIPP; Fiscal Year: 2014
    ..burgdorferi, causes Lyme neuroborreliosis by killing neurons and oligodendrocytes. This research could lead to a new way of treating Lyme neuroborreliosis. ..
  53. Lisa R Young; Fiscal Year: 2016
    ..Because type II cell dysfunction is a unifying feature of many fibrotic lung diseases, further study of HPS trafficking defects will likey elucidate mechanisms of pulmonary fibrosis with broad relevance. ..
  54. Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue
    Alan Chait; Fiscal Year: 2012
    ..abstract_text> ..
  55. JOAN WEINBERGER BERMAN; Fiscal Year: 2015
    ..We will also examine the mechanisms of PrPc release and the consequences of the soluble isoform on neuronal survival, astrocyte function and BBB integrity. ..
  56. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012
    ..is a recently identified CCCH-zinc finger containing protein, which was significantly induced by monocyte chemotactic protein 1 (MCP-1) and thus designated as MCPIP1...
  57. Israel F Charo; Fiscal Year: 2014
    ....
  58. Bo Liu; Fiscal Year: 2014
    ..abstract_text> ..
  59. Susanne Mohr; Fiscal Year: 2015
    ..We will examine the effects of manipulating these subsets on the progression of DR. Targeting monocyte subtypes may represent an ideal strategy for DR prevention and treatment. CellMax? ..
  60. Olga I Stenina; Fiscal Year: 2016
    ....
  61. Stuart B Goodman; Fiscal Year: 2016
    ....
  62. Victoria L Seewaldt; Fiscal Year: 2015
    ..Our studies provide innovative insight as to why obesity is associated with increased cancer incidence and aggressiveness. In addition, this work will provide a novel paradigm for the prophylactic treatment of high risk obese patients. ..
  63. David A Bernlohr; Fiscal Year: 2016
    ..Treatment of macrophages with leukotrienes results in an increase in iNOS and MCP1 expression while decreasing PPAR?...
  64. Genetic Epidemiology of HAD Susceptibility Genes
    Sunil Ahuja; Fiscal Year: 2009
    ..In support of this hypothesis, we recently demonstrated that the GA/GA genotype for the monocyte chemoattractant protein 1 (MCP-1) gene is associated with a significantly increased risk of developing HAD...
  65. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..Treatment of macrophages with leukotrienes results in an increase in iNOS and MCP1 expression while decreasing PPAR&#947;...
  66. CCR2 in Atherosclerosis and Monocyte Trafficking
    Israel F Charo; Fiscal Year: 2010
    ..Completion of these studies will deepen our understanding of the role of chemokines in monocyte homeostasis and the importance of macrophage activation in atherosclerotic plaque instability. ..
  67. Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV
    Victor Valcour; Fiscal Year: 2012
    ..Understanding why this happens will allow us to find better ways to prevent or treat this devastating complication of HIV. ..
  68. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..The proposed studies could contribute towards our understanding of the cardiovascular effects of the metabolic syndrome, and towards development of imaging strategies for assessment of its evolution and mechanisms. ..
  69. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
    ..e. in vivo correlation studies between CXCR2 expression and PCNA, oxidized LDL antigens, and scavenger receptor expression). ..
  70. MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDS
    Veena Antony; Fiscal Year: 2005
    ....
  71. A gene therapy for bacterial translocation in mice with whole body irradiation
    Fujio Suzuki; Fiscal Year: 2010
    ..The objective of this project is to develop a new gene therapy to mitigate sepsis stemming from bacterial translocation in mice irradiated with whole body gamma- rays. ..
  72. PLATELET REGULATION OF MONOKINE SYNTHESIS
    ANDREW WEYRICH; Fiscal Year: 2000
    ..Together, these results will begin defining how activated platelets, through P-selectin and RANTES, induce monokine synthesis. ..
  73. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ....
  74. Mechanisms of Transmigration of HIV Infected Cells Across the Blood Brain Barrier
    TONI KAY ROBERTS; Fiscal Year: 2010
    ....
  75. PHOSPHOLIPASE REGULATION OF MONOCYTE CHEMOTAXIS TO MCP-1
    MARTHA CATHCART; Fiscal Year: 2006
    ..These studies will significantly advance our understanding of this key inflammatory event. ..
  76. Chemokine antagonists in a murine model for scleroderma
    Anita Gilliam; Fiscal Year: 2003
    ..These pilot studies have high relevance to scleroderma and fibrosing diseases in general, and may lead to effective treatments for graft versus host disease as well. ..
  77. Functions of chemokine and TGF-B signaling in the breast cancer microenvironment
    Nikki Cheng; Fiscal Year: 2009
    ....
  78. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Upon signaling by chemokines such as MCP1 leukocytes are drawn toward endothelial cells...