MBL2

Summary

Gene Symbol: MBL2
Description: mannose binding lectin 2
Alias: COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose-binding protein C, collectin-1, mannan-binding lectin, mannose-binding lectin (protein C) 2, soluble (opsonic defect), mannose-binding lectin 2, soluble (opsonic defect)
Species: human

Top Publications

  1. ncbi High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1
    Melanie L Hart
    Rush Presbyterian St Luke s Medical Center, Department of Immunology Microbiology, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 18:1311-7. 2002
  2. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
  3. doi Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis
    Maria Dulce Kaoro Horie Wojitani
    Servico de Imunologia, Genetica e Infecções do Trato Reprodutivo da Disciplina de Ginecologia, da Faculdade de Medicina, da Universidade de Sao Paulo, Avenida Dr Enéas de Carvalho Aguiar 255, 10 andar, sala 10177, Cerkueira Cesar, Sao Paulo, SP, 05403900, Brazil
    Arch Gynecol Obstet 285:149-53. 2012
  4. ncbi The C1q and collectin binding site within C1q receptor (cell surface calreticulin)
    G R Stuart
    Department of Biochemistry, University of Oxford, UK
    Immunopharmacology 38:73-80. 1997
  5. ncbi Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease
    Frank Seibold
    Division of Gastroenterology, Inselspital, University of Bern, Switzerland
    Gastroenterology 127:1076-84. 2004
  6. ncbi Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome
    Anthony C Gordon
    Institute of Cell and Molecular Science, William Harvey Research Institute, Barts, UK
    Shock 25:88-93. 2006
  7. ncbi Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications
    Diego Peres Alonso
    Department of Parasitology, Institute for Biology and Biomedicine, Sao Paulo State University, Botucatu, Brazil
    J Infect Dis 195:1212-7. 2007
  8. doi Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma
    Dennis Eurich
    General, Visceral and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Liver Int 31:1006-12. 2011
  9. doi IgG glycosylation changes and MBL2 polymorphisms: associations with markers of systemic inflammation and joint destruction in rheumatoid arthritis
    Lone N Troelsen
    Department of Rheumatology, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Rheumatol 39:463-9. 2012
  10. doi Association of MIF-173G/C and MBL2 codon 54 gene polymorphisms with rheumatoid arthritis: a meta-analysis
    Qiang Xie
    School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, PR China
    Hum Immunol 73:966-71. 2012

Research Grants

  1. Gregory L Stahl; Fiscal Year: 2016
  2. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
  3. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
  4. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
  5. Gregory L Stahl; Fiscal Year: 2014
  6. Molecular Mechanism of Entamoeba histolytica phagocytosis
    Christopher D Huston; Fiscal Year: 2012
  7. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    GREGORY STAHL; Fiscal Year: 2009
  8. Development of novel immunotherapy for influenza virus infection
    Kazue Takahashi; Fiscal Year: 2011
  9. Evolutionary lead optimization for immunotherapy of Marburg & Ebola viruses
    EMMETT VANCE SCHMIDT; Fiscal Year: 2010
  10. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013

Detail Information

Publications370 found, 100 shown here

  1. ncbi High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1
    Melanie L Hart
    Rush Presbyterian St Luke s Medical Center, Department of Immunology Microbiology, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 18:1311-7. 2002
    Mannose-binding lectin (MBL) is a C-type lectin of the innate immune system that binds to carbohydrates on the surface of certain microorganisms. Previous studies showed that MBL binds to gp120, the envelope glycoprotein of HIV-1...
  2. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  3. doi Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis
    Maria Dulce Kaoro Horie Wojitani
    Servico de Imunologia, Genetica e Infecções do Trato Reprodutivo da Disciplina de Ginecologia, da Faculdade de Medicina, da Universidade de Sao Paulo, Avenida Dr Enéas de Carvalho Aguiar 255, 10 andar, sala 10177, Cerkueira Cesar, Sao Paulo, SP, 05403900, Brazil
    Arch Gynecol Obstet 285:149-53. 2012
    The influence of functional polymorphisms in the genes coding for mannose-binding lectin (MBL) and interleukin-1 receptor antagonist (IL-1ra) on recurrent vulvovaginal candidiasis (RVVC) were examined in an urban Brazilian population.
  4. ncbi The C1q and collectin binding site within C1q receptor (cell surface calreticulin)
    G R Stuart
    Department of Biochemistry, University of Oxford, UK
    Immunopharmacology 38:73-80. 1997
    ..C1qR also interacts with the collectins SP-A, MBL, CL43 and conglutinin via a cluster of charged residues on the collagen tails of the ligands...
  5. ncbi Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease
    Frank Seibold
    Division of Gastroenterology, Inselspital, University of Bern, Switzerland
    Gastroenterology 127:1076-84. 2004
    ..Mannan-binding lectin (MBL), a component of the innate immune system, can bind to S. cerevisiae ...
  6. ncbi Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome
    Anthony C Gordon
    Institute of Cell and Molecular Science, William Harvey Research Institute, Barts, UK
    Shock 25:88-93. 2006
    Mannose-binding lectin (MBL) genetic polymorphisms result in deficiency of the encoded protein and increased susceptibility to infection, especially in children and the immunocompromised...
  7. ncbi Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications
    Diego Peres Alonso
    Department of Parasitology, Institute for Biology and Biomedicine, Sao Paulo State University, Botucatu, Brazil
    J Infect Dis 195:1212-7. 2007
    ..Mutations in the MBL2 gene decrease levels of MBL and may protect against development of VL...
  8. doi Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma
    Dennis Eurich
    General, Visceral and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Liver Int 31:1006-12. 2011
    ..Mannose-binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis...
  9. doi IgG glycosylation changes and MBL2 polymorphisms: associations with markers of systemic inflammation and joint destruction in rheumatoid arthritis
    Lone N Troelsen
    Department of Rheumatology, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Rheumatol 39:463-9. 2012
    To examine whether IgG glycosylation changes and MBL2 genotypes are associated with systemic inflammation and joint destruction in rheumatoid arthritis (RA).
  10. doi Association of MIF-173G/C and MBL2 codon 54 gene polymorphisms with rheumatoid arthritis: a meta-analysis
    Qiang Xie
    School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, PR China
    Hum Immunol 73:966-71. 2012
    ..the association between macrophage migration inhibitory factor (MIF) -173G/C (rs755622), mannose-binding lectin (MBL2) exon 1 codon 54 (rs1800450) gene polymorphisms and rheumatoid arthritis (RA) susceptibility in ethnically ..
  11. ncbi Distinct and overlapping functions of allelic forms of human mannose binding protein
    M Super
    Harvard Department of Pediatrics, Children s Hospital, Boston, Massachusetts
    Nat Genet 2:50-5. 1992
    Human mannose binding protein (MBP) is a C-type serum lectin involved in first-line host defense against a variety of bacterial, fungal and viral pathogens...
  12. ncbi Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections
    I A Yang
    Division of Thoracic Medicine, The Prince Charles Hospital, and Department of Medicine, University of Queensland, Brisbane, Australia
    Genes Immun 4:269-74. 2003
    ..Polymorphisms in the MBL2 gene reduce serum MBL levels and are associated with risk of infection...
  13. ncbi Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein
    Flemming Larsen
    Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Biol Chem 279:21302-11. 2004
    Deficiency of human mannose-binding lectin (MBL) caused by mutations in the coding part of the MBL2 gene is associated with increased risk and severity of infections and autoimmunity...
  14. ncbi The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Copenhagen University Hospital, Denmark
    J Rheumatol 28:935-42. 2001
    To determine whether variant alleles of the mannose binding lectin (MBL) gene causing low serum concentrations of MBL are associated with increased susceptibility to rheumatoid arthritis (RA) and erosive outcome in an inception cohort of ..
  15. ncbi Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients
    Dorthe Hellemann
    Department of Anaesthesiology and Intensive Care, Herlev, Copenhagen University Hospital, Rigshospitalet, Denmark
    Hum Mol Genet 16:3071-80. 2007
    Polymorphisms in the MBL2 gene, which affect the structure and influence on the serum concentration of mannose-binding lectin (MBL), are associated with inflammatory and infectious conditions...
  16. ncbi The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases
    Florence Teillet
    Laboratoires d Enzymologie Moléculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l énergie atomique Centre National de La Recherche Scientifique Université Joseph Fourier, Grenoble, France
    J Immunol 174:2870-7. 2005
    Mannan-binding lectin (MBL) is an oligomeric C-type lectin assembled from homotrimeric structural units that binds to neutral carbohydrates on microbial surfaces...
  17. pmc Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4
    Mingyong Wang
    Department of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China
    PLoS ONE 8:e83517. 2013
    ..Mannan-binding lectin (MBL),a member of the collectin family in the C-type lectin superfamily, is an important serum component associated with ..
  18. doi Functional mannose-binding lectin levels in patients with end-stage renal disease on maintenance hemodialysis
    Atsushi Satomura
    Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
    J Innate Immun 4:293-300. 2012
    Innate immunity is generally impaired in chronic renal failure (CRF). Mannose-binding lectin (MBL) has an important role in first-line host defense against pathogens via the lectin pathway...
  19. pmc Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway
    Inga Thorsen Vengen
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology Trondheim, Norway
    PLoS ONE 7:e42113. 2012
    ..Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are related to development of myocardial infarction (MI)...
  20. pmc The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10
    K Sastry
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115
    J Exp Med 170:1175-89. 1989
    The human mannose-binding protein (MBP) plays a role in first line host defense against certain pathogens. It is an acute phase protein that exists in serum as a multimer of a 32-kD subunit...
  21. ncbi Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT
    T Horiuchi
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Genes Immun 6:162-6. 2005
    ..We investigated whether mannose-binding lectin (MBL) gene polymorphisms that cause low levels of MBL are associated with the occurrence of major infections in patients,..
  22. ncbi Mannose-binding lectin levels in children with asthma
    Aysen Uguz
    Division of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Akdeniz University, Antalya, Turkey
    Pediatr Allergy Immunol 16:231-5. 2005
    Mannose-binding lectin (mbl), one of the important components of innate immunity, can activate the lectin pathway of the complement system...
  23. ncbi Mannose-binding lectin and vulvovaginal candidiasis
    Fei Liu
    Department of Obstetrics and Gynecology, First Hospital Peking University, Beijing, China
    Int J Gynaecol Obstet 92:43-7. 2006
    To investigate the effect of mannose-binding lectin (MBL) gene polymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC).
  24. pmc Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China
    Min Kang
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Hua Zhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan 430030, Hubei Province, China
    Arthritis Res Ther 8:R85. 2006
    Many studies have reported that polymorphisms of the mannose-binding lectin (MBL) gene are associated with autoimmune disease...
  25. ncbi MBL2 polymorphism and risk of severe infections in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation
    I Mølle
    Department of Haematology, University Hospital of Aarhus, THG, Aarhus, Denmark
    Bone Marrow Transplant 38:555-60. 2006
    ..lectin (MBL) is part of the innate immune system, and individuals homozygous for wild-type MBL encoding gene (MBL2) have a well-functioning MBL pathway of complement activation, in contrast to individuals carrying one or two ..
  26. doi Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusions
    Yavuz M Bilgin
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 48:601-8. 2008
    Serum levels of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, are highly variable, based on genetic variation...
  27. doi Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:1696-701. 2009
    One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway...
  28. doi Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms
    Takeyuki Shimizu
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1790:1705-10. 2009
    ..Mannose binding lectin (MBL) is another collectin molecule which has structural homology to SP-A...
  29. pmc Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection
    Wei Chuan Chang
    Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    BMC Immunol 11:64. 2010
    Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility...
  30. pmc Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
    Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA)...
  31. doi Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease
    Leokadia Bak-Romaniszyn
    Unit of Nutrition in Digestive Tract Disease, Medical University of Lodz, Lodz, Poland
    Scand J Gastroenterol 46:1275-8. 2011
    ..At least a fourth of patients are children. Mannan-binding lectin (MBL) is believed to be an important component of innate immunity, acting as an opsonin and activator of the lectin ..
  32. pmc Mannose-binding lectin codon 54 genetic polymorphism and vaginal protein levels in women with gynecologic malignancies
    Nicole S Nevadunsky
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Eur J Obstet Gynecol Reprod Biol 163:216-8. 2012
    Mannose-binding lectin (MBL), an innate immune system component that binds to carbohydrates, activates the complement cascade and promotes destruction of microorganisms and abnormal cells...
  33. pmc Mannose-binding lectin 2 gene and risk of adult glioma
    Dominique S Michaud
    Department of Epidemiology, Brown Public Health, Brown University, Providence, Rhode Island, USA
    PLoS ONE 8:e61117. 2013
    ..The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers...
  34. doi The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus-positive cervical lesions
    Manola Comar
    Department of Reproductive, Developmental, and Public Health Sciences, University of Trieste, and Clinical Unit of Hygiene and Preventive Medicine, IRCCS Burlo Garofolo, Trieste, Italy
    Hum Immunol 72:663-6. 2011
    ..To disclose a possible role of the gene encoding for the mannose-binding lectin, MBL2, in susceptibility to BKV infection, we analyzed functional polymorphisms in the first exon of MBL2 in women ..
  35. doi Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation
    Janna M Munster
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:1857-63. 2008
    ..Mannose binding lectin (MBL), a recognition molecule of innate immunity, has been associated with transplant outcome in other solid organ ..
  36. ncbi Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese
    T Horiuchi
    Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Genes Immun 1:464-6. 2000
    Mannose binding lectin (MBL) deficiency may be associated with increased susceptibility to infection and autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  37. doi Influence of MBL-2 mutations in the infection risk of patients with follicular lymphoma treated with rituximab, fludarabine, and cyclophosphamide
    Joaquin Martinez-Lopez
    Hospital 12 de Octubre, Madrid, Spain
    Leuk Lymphoma 50:1283-9. 2009
    ..The aim of the present study was to analyze mannose-binding lectin (MBL-2 gene) mutations and their association with severe infections and event-free survival in patients diagnosed with ..
  38. doi Sepsis in acute myeloid leukaemia patients receiving high-dose chemotherapy: no impact of chitotriosidase and mannose-binding lectin polymorphisms
    Anja Klostergaard
    Department of Haematology, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Haematol 85:58-64. 2010
    ..CHIT1) may be associated with Gram-negative sepsis in children with AML, and polymorphism in the MBL-coding gene (MBL2) seems to modify the risk of infections in several patient groups...
  39. ncbi Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population
    R M Minchinton
    Cooperative Research Centre for Vaccine Technology at the Australian Red Cross Blood Service, Brisbane, QLD, Australia
    Scand J Immunol 56:630-41. 2002
    The mannose-binding lectin (MBL) pathway of complement activation is an important component of innate host defence. Numerous studies have described associations between the MBL genotype, MBL levels and disease susceptibility...
  40. ncbi Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin
    Katy J Fidler
    Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guilford Street, London, WC1 N 1EH, UK
    Intensive Care Med 30:1438-45. 2004
    To determine whether pediatric PICU patients with mannose-binding lectin (MBL) gene polymorphisms associated with low levels of the functional protein have an increased risk of developing sepsis and SIRS.
  41. doi S-nitrosylation of mannose binding lectin regulates its functional activities and the formation of autoantibody in rheumatoid arthritis
    Bhawna Gupta
    Proteomics and Structural Biology Division, Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110 007, India
    Nitric Oxide 18:266-73. 2008
    The possibility of post-translational modifications of mannose binding lectin (MBL) leading to functional impairment of the MBL pathway and the presence of anti-MBL autoantibodies were reported earlier in rheumatoid arthritis (RA)...
  42. ncbi Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples
    Bhawna Gupta
    Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110 007, India
    J Hum Genet 50:583-91. 2005
    Single nucleotide polymorphisms in the mannose-binding lectin (MBL2) gene, as well as the serum MBL2 level, have been associated with various autoimmune diseases...
  43. ncbi Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls
    Saedis Saevarsdottir
    Department of Immunology and Center for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland
    J Rheumatol 34:1692-5. 2007
    ..and synovial fluid; its levels vary widely, and the variations are strongly associated with polymorphisms in the MBL2 gene...
  44. ncbi Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression
    M Boniotto
    Genetic Service, IRCCS Burlo Garofolo and Chair of Genetics, University of Trieste, Via dell Istria 65 1, 34137 Trieste, Italy
    Genes Immun 1:346-8. 2000
    We investigated the polymorphisms of the promoter region of the MBL2 gene, which codifies for the Mannose-binding protein (MBP)...
  45. ncbi Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients
    P Garred
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Genes Immun 2:442-50. 2001
    This study describes the importance of mannose-binding lectin (MBL) variant alleles for systemic lupus erythematosus (SLE) and accompanying infections in a population-based cohort...
  46. ncbi Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus
    Olaf Neth
    Immunobiology Unit, Institute of Child Health and Great Ormond Street Hospital for Children, National Health Service Trust, 30 Guilford Street, London, WC1N 1EH, UK
    J Immunol 169:4430-6. 2002
    Human mannose-binding lectin (MBL) is a serum protein of the innate immune system that circulates as a complex with a group of so-called MBL-associated serine proteases (MASP-1, MASP-2, and MASP-3)...
  47. ncbi Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin
    Melanie L Hart
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, 1563 W Congress Parkway, Chicago, IL 60612, USA
    J Gen Virol 84:353-60. 2003
    Mannose-binding lectin (MBL), a C-type lectin component of the human innate immune system, binds to the gp120 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1)...
  48. pmc Inhibition of DC-SIGN-mediated trans infection of T cells by mannose-binding lectin
    Gregory T Spear
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Immunology 110:80-5. 2003
    ..We investigated the possibility that mannose-binding lectin (MBL), a soluble lectin that functions as a recognition molecule in innate immunity and that binds to HIV, could block ..
  49. ncbi Interaction of mannose-binding lectin with HIV type 1 is sufficient for virus opsonization but not neutralization
    Hongyu Ying
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 20:327-35. 2004
    Mannose-binding lectin (MBL), a microbe-recognition protein in serum, binds to high mannose glycans on HIV-1 gp120 and has been reported to neutralize the cell line-adapted strain HIV(IIIB)...
  50. ncbi Association between mannose-binding lectin and vascular complications in type 1 diabetes
    Troels K Hansen
    Immunoendocrine Research Unit, Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Norrebrogade 42 44, DK 8000 Aarhus C, Denmark
    Diabetes 53:1570-6. 2004
    ..We investigated serum mannose-binding lectin (MBL) levels and polymorphisms in the MBL gene in type 1 diabetic patients with and without diabetic nephropathy and ..
  51. ncbi Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections
    Kazunori Gomi
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Chest 126:95-9. 2004
    To clarify how mannose-binding lectin (MBL) participates in the pulmonary defense system.
  52. ncbi High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype
    Szabolcs Rugonfalvi-Kiss
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Stroke 36:944-8. 2005
    Mannose-binding lectin (MBL) is thought to influence the pathophysiology of cardiovascular disease by decreasing the risk of advanced atherosclerosis and by contributing to enhanced ischemia reperfusion injury...
  53. ncbi Tumor-suppressive effects of MBP-1 in non-small cell lung cancer cells
    Asish K Ghosh
    Department of Pathology and Cancer Center, Saint Louis University, St Louis, Missouri 63104, USA
    Cancer Res 66:11907-12. 2006
    ..We have previously shown the antiproliferative effect of MBP-1 on several human cancer cells...
  54. doi The role of mannose-binding lectin in systemic lupus erythematosus
    Odirlei André Monticielo
    Division of Rheumatology, Department of Internal Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Rheumatol 27:413-9. 2008
    ..Recent studies proposed a role to the mannose-binding lectin (MBL) in the SLE physiopathogenesis...
  55. doi Detrimental effects of mannose-binding lectin (MBL2) promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression
    A Mangano
    Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatria Juan P Garrahan, Buenos Aires, Argentina
    J Infect Dis 198:694-700. 2008
    ..Polymorphisms in the MBL2 gene reduce the level of protein and alter its structure...
  56. doi Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men
    Aino Rantala
    National Public Health Institute, Oulu, Finland
    J Infect Dis 198:1247-53. 2008
    Mannose-binding lectin (MBL) is an important component of innate immunity, and its deficiency is associated with susceptibility to recurrent infections.
  57. pmc Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy
    Mari A Kaunisto
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes 58:1710-4. 2009
    ..We investigated whether MBL2 polymorphisms are associated with type 1 diabetes or diabetic nephropathy and whether patients with nephropathy ..
  58. doi Mannose-binding lectin as a risk factor for acute coronary syndromes
    Erkki Pesonen
    Department of Pediatric Cardiology, University Hospital of Lund, Sweden
    Ann Med 41:591-8. 2009
    Mannose-binding lectin (MBL) is a multifunctional protein involved in innate immunity. We tested whether MBL and elevated viral and bacterial antibodies were risk factors for acute coronary events.
  59. ncbi Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil
    S Sheriff
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543 4000, USA
    Nat Struct Biol 1:789-94. 1994
    ..The spatial arrangement of the carbohydrate recognition domains suggest how MBP trimers form the basic recognition unit for branched oligosaccharides on microorganisms.
  60. ncbi A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
    H O Madsen
    Department of Clinical Immunology, Righospitalet, Copenhagen N, Denmark
    Immunogenetics 40:37-44. 1994
    Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune defence...
  61. pmc Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition
    O Neth
    Immunobiology Unit, Institute of Child Health, University College London, NHS Trust, London, United Kingdom
    Infect Immun 68:688-93. 2000
    Mannose-binding lectin (MBL) is a collagenous serum lectin believed to be of importance in innate immunity. Genetically determined low levels of the protein are known to predispose to infections...
  62. ncbi Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood
    A Koch
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    JAMA 285:1316-21. 2001
    ..that increased susceptibility to certain infections is associated with low serum levels of mannose-binding lectin (MBL) due to MBL variant alleles...
  63. pmc C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
    ..Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells and stimulate ingestion of these by ..
  64. ncbi Mannose-binding lectin and the prognosis of fulminant hepatic failure caused by HBV infection
    Yukiya Hakozaki
    Department of Internal Medicine, Japan Defense Forces Central Hospital, Tokyo, Japan
    Liver 22:29-34. 2002
    The mannose-binding lectin (MBL) gene was reported to play an important role in determining the clinical outcome of persistent hepatitis B virus (HBV) infection...
  65. ncbi The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin
    Adrienne Nagy
    Budai Children s Hospital, Budapest, Hungary
    J Allergy Clin Immunol 112:729-34. 2003
    ..Data about the role of C pneumoniae in the initiation and development of asthma in children are controversial...
  66. pmc Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus
    Lei Shi
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, JRG 1402, Boston, MA 02114, USA
    J Exp Med 199:1379-90. 2004
    ..aureus. The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a ..
  67. pmc A population-based study of morbidity and mortality in mannose-binding lectin deficiency
    Morten Dahl
    Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK 2730 Herlev, Denmark
    J Exp Med 199:1391-9. 2004
    Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death...
  68. ncbi Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study
    Peter Hovind
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 54:1523-7. 2005
    Inflammation and complement activation via the mannose-binding lectin (MBL) pathway have been suggested to play a role in the pathogenesis of diabetic microvascular complications...
  69. ncbi Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes
    Jeanette Seyfarth
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Mol Immunol 43:962-71. 2006
    ..Therefore, we investigated whether mRNA transcribed from the human mbl2 gene as well as the masp genes was present in different tissues...
  70. ncbi The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis
    Young Ho Lee
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 52:3966-74. 2005
    Mannose-binding lectin (MBL) enhances opsonization and activates complement...
  71. ncbi Systemic lupus erythematosus in a multiethnic US cohort: XXXIV. Deficient mannose-binding lectin exon 1 polymorphisms are associated with cerebrovascular but not with other arterial thrombotic events
    Jaime Calvo-Alen
    University of Alabama at Birmingham, USA
    Arthritis Rheum 54:1940-5. 2006
    To study the association between deficient mannose-binding lectin (MBL) genotypes and arterial thrombotic events in systemic lupus erythematosus (SLE).
  72. ncbi Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin
    J M Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    Diabetologia 49:2402-11. 2006
    Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance.
  73. ncbi Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene
    Sharon R Pine
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 99:1401-9. 2007
    ..Five polymorphisms in the promoter and first exon of the MBL2 gene alter the expression and function of MBL in humans and are associated with inflammation-related disease ..
  74. ncbi Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents
    Jacqueline Araujo
    Pediatric Endocrinology Unit of Clinical Hospital, Federal University of Pernambuco and Maternal and Children s Institute of Pernambuco, Recife, Brazil
    Hum Immunol 68:739-43. 2007
    ..constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphisms in exon 1, as well as nucleotide variations in the promoter region of the gene, have been ..
  75. ncbi Mannose-binding lectin genotypes are associated with shorter gestational age. An evolutionary advantage of low MBL production genotypes?
    F E van de Geijn
    Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, Room Ee 965, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Immunol 45:1514-8. 2008
    The complement factor mannose-binding lectin (MBL) is associated with adverse pregnancy outcome. MBL serum concentrations are increased from early pregnancy onwards and depend upon several gene polymorphisms...
  76. doi Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children
    J Aittoniemi
    Department of Clinical Microbiology, Centre for Laboratory Medicine, Pirkanmaa Hospital District, Tampere, Finland
    Hum Immunol 69:108-11. 2008
    ..lectin (MBL) is a key mediator of innate immunity, the insufficiency of which is caused by point mutations in the MBL2 gene...
  77. doi Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation
    Charles G Mullighan
    Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 112:2120-8. 2008
    ..We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation ..
  78. doi Mannose-binding lectin polymorphisms are not associated with rheumatoid arthritis--confirmation in two large cohorts
    F E van de Geijn
    Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Rheumatology (Oxford) 47:1168-71. 2008
    ..results have been described on the association between genotypes of the complement factor mannose-binding lectin (MBL) and disease susceptibility and severity...
  79. pmc Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 10:5. 2009
    ..MBL gene (MBL2) variants with between 12 to 25% allele frequency in Caucasian and other populations, result in markedly reduced ..
  80. doi Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice
    Robert A Matthijsen
    Department of Surgery, Maastricht University Medical Centre and School for Nutrition and Metabolism, Maastricht, Netherlands
    Circulation 119:2188-95. 2009
    With consideration of the central role of the innate immune system in atherogenesis and mannose-binding lectin (MBL) as an innate regulator of immunity, the role of MBL in experimental and human atherosclerosis was assessed.
  81. pmc Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
    Alvaro Cervera
    Comprehensive Stroke Center, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Medical School, University of Barcelona, Barcelona, Spain
    PLoS ONE 5:e8433. 2010
    ..The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs)...
  82. pmc Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
    Yunhua L Muller
    Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2080-5. 2010
    b>MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus...
  83. doi Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus
    Lone N Troelsen
    Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Rheumatol 37:1815-21. 2010
    ..Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and ..
  84. pmc Mannose-binding lectin genotype and phenotype in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial
    L G Mellbin
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 33:2451-6. 2010
    The present study characterizes mannose-binding lectin (MBL), an activator of the complement system and thereby important for inflammatory activation, in patients with diabetes and myocardial infarction.
  85. pmc Mannose-binding lectin deficiency influences innate and antigen-presenting functions of blood myeloid dendritic cells
    Melinda M Dean
    Australian Red Cross Blood Service, 44 Musk Avenue Kelvin Grove, QLD, Australia
    Immunology 132:296-305. 2011
    ..Individuals with mutations in exon 1 of the MBL2 gene have reduced MBL ligand binding and complement activation function and increased incidence of infection...
  86. doi Genotypes coding for mannose-binding lectin deficiency correlated with cryptococcal meningitis in HIV-uninfected Chinese patients
    Xue Ting Ou
    Department of Infectious Diseases, Huashan Hospital, Shanghai, China
    J Infect Dis 203:1686-91. 2011
    There is increasing evidence that mannose-binding lectin (MBL) has a complex role in many diseases, particularly in infectious diseases. However, the relationship between MBL deficiency and cryptococcal meningitis has not been clarified...
  87. pmc Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation
    J M Kwakkel-van Erp
    Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Immunol 165:410-6. 2011
    ..Mannose-binding lectin (MBL) is a pattern recognition molecule of complement and an important component of the innate immunity...
  88. doi The role of mannose-binding lectin in pneumococcal infection
    M Isabel Garcia-Laorden
    Dept of Immunology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
    Eur Respir J 41:131-9. 2013
    The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial...
  89. doi Mannose-binding lectin and susceptibility to schistosomiasis
    Justin S Antony
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    J Infect Dis 207:1675-83. 2013
    Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious ..
  90. pmc MBL2 variations and malaria susceptibility in Indian populations
    Aditya Nath Jha
    CSIR Centre for Cellular and Molecular Biology, Hyderabad, India
    Infect Immun 82:52-61. 2014
    Human mannose-binding lectin (MBL) encoded by the MBL2 gene is a pattern recognition protein and has been associated with many infectious diseases, including malaria...
  91. ncbi High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene
    R J Lipscombe
    Molecular Immunology Unit, Institute of Child Health, London
    Hum Mol Genet 1:709-15. 1992
    ..a point mutation (GGC-->GAC) in codon 54 of exon 1 of the gene for the human lectin mannose binding protein (MBP)...
  92. ncbi A second serine protease associated with mannan-binding lectin that activates complement
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Nature 386:506-10. 1997
    ..surfaces, and by an antibody-independent pathway that is initiated by the binding of mannan-binding lectin (MBL; first described as mannan-binding protein) to carbohydrates...
  93. ncbi The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
    I P Fraser
    Laboratory of Developmental Immunology and Department of Pediatrics, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Semin Immunol 10:363-72. 1998
    ..In this way, these pattern recognition molecules are able to serve as a link between the innate and adaptive immune systems...
  94. ncbi Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1
    M Saifuddin
    Department of Immunology Microbiology, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    J Gen Virol 81:949-55. 2000
    Mannose-binding lectin (MBL) is present in human serum and plays an important role in innate immunity by binding to carbohydrate on micro-organisms...
  95. pmc Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1
    C D Collard
    Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 159:1045-54. 2001
    Oxidative stress increases endothelial mannose-binding lectin (MBL) binding and activates the lectin complement pathway (LCP). However, the molecular mechanism of MBL binding to the endothelium after oxidative stress is unknown...
  96. ncbi Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency
    Georgina S Butler
    Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 277:17511-9. 2002
    Mannose-binding lectin (MBL) plays a critical role in innate immunity...
  97. ncbi Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation
    Charles G Mullighan
    Research and Development, Australian Red Cross Blood Service, South Australia
    Blood 99:3524-9. 2002
    ..We investigated associations between MBL2 gene polymorphisms and risk of major infection following allogeneic SCT...
  98. ncbi The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups
    Hana M El Sahly
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Scand J Infect Dis 36:106-8. 2004
    In order to investigate the role of MBL gene polymorphisms in susceptibility to tuberculosis (TB) we genotyped 487 TB cases and 232 controls...
  99. ncbi Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi
    Jodene Fitness
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 71:341-9. 2004
    ..Genetic susceptibility to TB in Africans appears polygenic. The relevant genes and variants may vary significantly between populations, and may be affected by HIV infection status...
  100. ncbi Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    Ainsley M Sutherland
    University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
    Crit Care Med 33:638-44. 2005
    ....
  101. ncbi Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population
    Seong Gene Lee
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea
    Mol Immunol 42:969-77. 2005
    ..We have analyzed six SNPs of MBL2 gene--three at promoter (-550, -435, and -221), one at 5'-untranslational region (UTR) (+4), and two at coding (..

Research Grants64

  1. Gregory L Stahl; Fiscal Year: 2016
    ..is the production of reactive oxygen species, which we showed to be responsible for mannose binding lectin (MBL) ligand expression in ischemia/reperfusion (I/R) models...
  2. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..We believe this will be a fruitful area of investigation, as multiple polymorphisms in the MBL2 gene lead to MBL deficiency in 10-15% of the population...
  3. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..inducible protein (RIG-I), the collectins surfactant proteins A and D (SP-A, SP-D) and mannose binding lectin (MBL), Vitamin D related genes (VDR), and genes influencing down-stream cytokines such as interferon-alpha (IFN-[..
  4. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
    ..Mannose binding lectin (MBL), coded by MBL2 gene, is an active phase protein that mounts innate immune response against risk of infections by recognizing ..
  5. Gregory L Stahl; Fiscal Year: 2014
    ..In the last funding cycle, we showed that inhibition of mannose binding lectin (MBL) protected the ischemic gastrointestinal system from the primary ischemic event...
  6. Molecular Mechanism of Entamoeba histolytica phagocytosis
    Christopher D Huston; Fiscal Year: 2012
    ..In mammals, collectin family members (e.g., mannose binding lectin (MBL)) and the structurally related protein C1q bind to apoptotic cells, and initiate phagocytosis by interaction of ..
  7. MECHANISMS OF COMPLEMENT INDUCED ENDOTHELIAL DYSFUNCTION
    GREGORY STAHL; Fiscal Year: 2009
    ..g., cobra venom factor) and genetically deficient complement component (e.g., C3, C4, MBL, factor D, C1qa) mice have revealed an important role of complement and the specific pathways involved in ischemia/..
  8. Development of novel immunotherapy for influenza virus infection
    Kazue Takahashi; Fiscal Year: 2011
    ..The proposal is based on the fact that mannose-binding lectin (MBL) is a broad-spectrum molecule of innate immunity...
  9. Evolutionary lead optimization for immunotherapy of Marburg & Ebola viruses
    EMMETT VANCE SCHMIDT; Fiscal Year: 2010
    ..The proposal builds on the fact that the mannose-binding lectin (MBL) is a broad-spectrum molecule of innate immunity...
  10. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013
    ..funding period, we have characterized a major virulence protein of Acanthamoeba, the mannose-binding protein (MBP), that mediates the adhesion of parasites to host cells...
  11. Blocking Milk-Borne HIV by Commensal Bacteria
    Lin Tao; Fiscal Year: 2004
    ..Specifically, we will study a novel factor of the oral innate immunity--mannose-binding lectin (MBL)--of commensal bacteria...
  12. EXPRESSION OF THE MYELIN BASIC PROTEIN GENE
    CARMIE PUCKETT; Fiscal Year: 1991
    ..One of those mutants, the shiverer mouse, has been shown to have a partial deletion of the myelin basic protein (MBP) gene. This single gene codes for four different forms of MBP, a major myelin protein...
  13. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..feature of these three pathways is the production of reactive oxygen species, which we showed to be responsible for MBL ligand expression in ischemia/reperfusion models...
  14. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    ..L-ficolin is a recently discovered innate opsonin in the blood that resembles mannose binding lectin (MBL) in structure, targets acetyl groups, and initiates the lectin-dependent complement cascade by activating MBL- ..
  15. David J Salant; Fiscal Year: 2015
    ..The presence of mannan-binding lectin (MBL) and activated C4 but absent C1q in the immune deposits suggests that the lectin pathway may be involved...
  16. MICHAEL CRAIG CARROLL; Fiscal Year: 2014
    ..we reported a third pathway in which lymph-borne influenza (UV-inactivated) was rapidly opsonized via mannan binding lectin and bound by macrophages lining both the subcapsular sinus and the medullary regions...
  17. Mannose binding lectin and outcomes following CABG
    GREGORY L contact STAHL; Fiscal Year: 2010
    ..Preliminary haplotype data from the CABG Genomics Program demonstrate that the high expressor MBL2 "LYQA secretor" haplotype is an independent predictor of postoperative myocardial infarction following CABG surgery...
  18. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
    ..Activation of complement via this pathway depends on the binding of mannan binding lectin (MBL) to mannose residues on the cell surface of microorganisms...
  19. Mannose-Binding Lectin Haplotypes and Infection Risk
    John Landers; Fiscal Year: 2004
    Mannose-binding lectin (MBL) plays an important role in the innate immune response via its ability to recognize sugar moieties on the surfaces of a great variety of pathogens...
  20. Myelin Composition Influence on Bilayer Interactions in Multiple Sclerosis
    Jacob N Israelachvili; Fiscal Year: 2010
    ..that the interactions between the cytoplasmic sides of the membranes are due primarily to myelin basic protein (MBP) that couples to the lipid composition, with the anionic lipid and protein isoform content being especially ..
  21. Mining the Multiple Sclerosis miRNome for Disease Markers
    Amy E Lovett Racke; Fiscal Year: 2010
    ..MS is considered an autoimmune disease, as supported by the presence of activated myelin basic protein (MBP)-specific T cells...
  22. Tibor T Glant; Fiscal Year: 2016
    ..The protective/suppressive regions of DBA/2 origin were stepwise reduced to ~3.0 mega basepair (Mbp) size, and 4 parents (DBA/2 and BALB/c) and 6 PGISpA-resistant and PGISpA-susceptible congenic mice were sequenced ..
  23. Arthur A Vandenbark; Fiscal Year: 2014
    ..and Th17 cells specific for neuroantigens such as myelin oligodendroglial glycoprotein (MOG), myelin basic protein (MBP) and proteolipid protein (PLP) can induce severe signs of experimental autoimmune encephalomyelitis (EAE) in mice ..
  24. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..provided by applicant): Modulation of immune responses against CNS antigens, such as myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG), is a goal for therapeutic intervention in multiple sclerosis...
  25. Structure and function analysis of C1/C1q and MBL using a novel peptide inhibitor
    NEEL KUMAR KRISHNA; Fiscal Year: 2012
    ..the molecular basis of complement activation upon initial recognition of ligand by the C1q (classical pathway) and MBL (lectin pathway) complex as a prerequisite to the development of therapeutic methods to attenuate or prevent host ..
  26. Kamal D Moudgil; Fiscal Year: 2014
    ..including myelin oligodendrocyte glycoprotein (MOG), proteolipid protein (PLP), and myelin basic protein (MBP) have been implicated in the pathogenesis of MS...
  27. Shirley ShiDu Yan; Fiscal Year: 2014
    ..microarray analysis to identify differences in gene expression between mice-induced by myelin basic protein (MBP) and naive mice...
  28. FENG C LIN; Fiscal Year: 2015
    ..in vivo bone turnover by assessing bone structure in several OVXed complement knockout mice (Factor D-/-, C1q-/-, MBL-/-, C3-/-, C3aR-/- ,C5aR-/-, and C3aR-/-C5aR-/-) and wild type (WT) controls;microCT and bone histomorphometry will ..
  29. The role of lectin-complexes in complement-mediated coagulopathy
    Laura R La Bonte; Fiscal Year: 2011
    ..Preliminary data demonstrates multiple interactions of the MBL complex with several coagulation proteins...
  30. Inflammation and Degeneration of Optic Nerve in EAE
    Naren L Banik; Fiscal Year: 2013
    ..In vitro interferon (IFN[unreadable]) induced calpain activation in glial cells and MBP-specific T cell supernatant degraded MBP...
  31. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..anti-TCR response, we will utilize DR2 mice that also express a human TCR specific for myelin basic protein (MBP)-85-99 peptide...
  32. ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAE
    Kalipada Pahan; Fiscal Year: 2009
    ..Second, we will study the role of p40-2 and p40 in modulating the ability of MBP-specific T cells to differentiate into either Th1 or Th2 type using recombinant proteins as well as monoclonal ..
  33. Miroslaw Janowski; Fiscal Year: 2014
    ..cells, and will also enable post mortem assessment of graft differentiation using immunohistochemistry against MBP. Our preliminary studies have demonstrated that the survival of cells grafted into immunocompetent hosts is highly ..
  34. Encapsulated Active Vitamin D Vaccine for the Treatment of Multiple Sclerosis
    Kristy M Ainslie; Fiscal Year: 2012
    ..the polymer acetalated dextran (Ac-DEX) that encapsulate the active form of vitamin D, and myelin basic protein (MBP) will initiate the formation of MBP specific inducible T-reg cells (iT-regs) capable of suppressing MS in an ..
  35. Recognition of Self and Mutated Self by Autoimmune and Tumor-Specific TCRs
    SUZANNE LOUISE TOPALIAN; Fiscal Year: 2012
    ..2005, however, we reported the structure of an autoimmune TCR bound to a self- peptide from myelin basic protein (MBP) and HLA-DR2a...
  36. Cell-based Gene Therapy for Multiple Sclerosis
    KATHERINE LOUIE; Fiscal Year: 2010
    ..to our therapy and that can be used in a clinical trial to monitor for safety, * to generate and characterize the MBP peptide-secreting human fibroblasts (MRC5-MBP) that will constitute Anergix's therapy Immune studies will be ..
  37. VERNON MICHAEL HOLERS; Fiscal Year: 2016
    ..that the alternative pathway is primed in vivo for the development of pathologic injury by the activities of the MBL associated serum protease (MASP) protein MASP1 on pro-factor D, as well as define the role of the receptors for the ..
  38. Characterization of lymphocytes that suppress EAE
    Juan LaFaille; Fiscal Year: 2010
    ..Mice which harbor a monoclonal myelin basic protein (MBP)-specific ab T cell compartment develop EAE spontaneously...
  39. Buprenorphine effects on oligodendrocyte development and axonal growth
    Carmen Sato Bigbee; Fiscal Year: 2010
    ..buprenorphine caused an accelerated brain expression of the four major splicing isoforms of myelin basic protein (MBP), oligodendroglial and myelin components that are considered to be markers of mature oligodendrocytes (OLGs)...
  40. Transcriptional control of oligodendrocyte differentiation and myelination
    MENSHENG QIU; Fiscal Year: 2013
    ..2 in oligodendrocyte cell line inhibits MBP gene expression, raising the possibility that Nkx2...
  41. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
    ..for oligodendroglia are glycerol phosphate dehydrogenase (GPDH), galactocerebroside (GC) and myelin basic protein (MBP)...
  42. ANTI-IDIOTYPIC AUTOIMMUNITY IN MULTIPLE SCLEROSIS
    Christine Rohowsky Kochan; Fiscal Year: 1992
    ..of T cell clones specifically reactive against myelin components, in particular, the basic protein of myelin (MBP)...
  43. DEPLETION OF AUTOREACTIVE/T CELLS IN MULTIPLE SCLEROSIS
    Jingwu Zhang; Fiscal Year: 2000
    DESCRIPTION (Adapted from Investigator's abstract): Myelin basic protein (MBP)-specific T-cells may play an important role in the pathogenesis of multiple sclerosis (MS)...
  44. REGULATION OF MYELIN BASIC PROTEIN GENE EXPRESSION
    Shohreh Amini; Fiscal Year: 2000
    The MBI regulatory sequence of the myelin basic protein (MBP) gene spanning between nucleotides -14 to -50 with respect to the transcription start site is critical for cell type-specific transcription of the MBP gene which encodes the ..
  45. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
    ..When an MBP oligomer binds to a target surface, MBP-Associated Serine Proteases, or MASPs, are activated, which in turn ..
  46. Protein switches created by domain insertion: modeling, prediction, and design.
    MONICA BERRONDO; Fiscal Year: 2010
    ..was engineered through combinatorial library searching to couple the function of maltodextrin binding protein (MBP) and TEM-1 3-lactamase (BLA)...
  47. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..The SNP data obtained in aim1 will be used to map these QTLs to a high resolution (1-2 megabase pairs [Mbp]), to confirm the QTL haplotype structure and to determine which genes within the intervals have non-synonymous ..
  48. Tibor T Glant; Fiscal Year: 2014
    ..2-151.7 Mbp region, including PTPN22) shows the most prominent linkage with RA, after the MHC...
  49. Christopher A Bradfield; Fiscal Year: 2014
    ..We have mapped the mouse PPCD1 gene, designated "Ppcd1", to a 6.2 Mbp interval on Chromosome 2, and identified a hemizygous 87,000 bp duplication in this interval...
  50. Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic Leukemia
    Kyoko Hayakawa; Fiscal Year: 2010
    ..of one kind of autoreactive B-cell in the mouse that may model the cell type with a propensity to become MBL and eventually, CLL...
  51. Preserving beta-lactam utility against pathogens producing all classes of beta-la
    LUIGI XERRI; Fiscal Year: 2012
    ..product demonstrates potent inhibition of carbapenem-resistant strains of Enterobacteriaceae that express both an MBL and at least one serine-b-lactamase...
  52. Timothy Palzkill; Fiscal Year: 2016
    ..active site positions, a high resolution picture of the determinants of catalysis and substrate specificity for an MBL will emerge...
  53. Genetic analysis of a spontaneous mutation in a rat with a novel hind limb defect
    Debasish Sinha; Fiscal Year: 2010
    ..This disease interval has been reduced to a chromosomal region of 2.7 Mbp. Based on the Reference Sequence annotation database for the most current rat genome assembly, there are 8 ..
  54. Molecular Pathogenesis of Monoclonal B Cell Lymphocytosis and CLL
    Mark C Lanasa; Fiscal Year: 2013
    ..Monoclonal B cell lymphocytosis (MBL) is an asymptomatic hematologic syndrome characterized by small accumulations of clonal B lymphocytes in the ..
  55. Tony L Yaksh; Fiscal Year: 2016
    ..a fundamentally novel mechanism explaining this phenomenon: selective proteolysis of myelin basic protein (MBP) by matrix metalloproteinases (MMPs) releases the cryptic immunodominant epitopes, MBP84-104 and MBP69-86, normally ..
  56. GURJEET SINGH BIRDEE; Fiscal Year: 2016
    ..These projects will inform and advance implementation of MBP for patients with chronic disease...
  57. James J Hickman; Fiscal Year: 2016
    ..Schwann cell myelination of motoneurons, with complete Node of Ranvier formation, and derived pure populations of MBP (myelin basic protein) positive oligodendrocytes from human mesenchymal stem cells...
  58. Development of MASP-2 MoAbs for the treatment of diabetic nephropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2010
    ..The MBL- associated protease 2 (MASP-2), an enzyme unique to the lectin pathway and required for its function, has been ..
  59. Zhaolan Zhou; Fiscal Year: 2014
    ..ligase (BirA) and GFP in a spatially and temporally controlled manner;while the other line carries an endogenous MBP tagged with a biotinylation signal sequence...
  60. Programming dendritic cells to induce tolerogenic response and suppress brain inf
    Santhakumar Manicassamy; Fiscal Year: 2013
    ..EAE (Aim 1);(ii) Test the hypothesis that the [unreadable]-catenin/TCF-4 pathway in DCs is critical for inducing MBP-specific T regulatory cells differentiation and suppressing pathological Th1/Th17 cell differentiation (Aim 2);(iii)..
  61. Assessing Workplace Phthalate Exposures Among Massage Therapy Students
    VICTORIA PAK; Fiscal Year: 2010
    ..therapist students to phthalates in the work setting;2)To determine the levels of the urinary biomarkers MEP and MBP, the main metabolites of Diethyl Phthalate (DEP) and Dibutyl Phthalate (DBP) in massage therapist students, while ..
  62. Generation of Ikaros conditional knockout mice
    SUSAN M WINANDY; Fiscal Year: 2012
    ..This will be done with the assistance of the Mouse Biology Program (MBP) at University of California, Davis...
  63. CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENES
    Steven Ackerman; Fiscal Year: 2006
    ..Our objective is to continue these studies in vivo using the IL-5Ralpha subunit and granule major basic protein (MBP) genes as models for defining the eosinophil developmental program in the general context of myelopoiesis...
  64. FACTORS DETERMINING PROTEIN LOCALIZATION IN E. COLI
    JANNE CANNON; Fiscal Year: 1992
    ..has been intensively investigating the synthesis and secretion of the periplasmic maltose-binding protein (MBP) of Escherichia coli using a combination of genetic and biochemical approaches...