MASP1

Summary

Gene Symbol: MASP1
Description: mannan binding lectin serine peptidase 1
Alias: 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan-binding lectin serine protease 1, C4/C2 activating component of Ra-reactive factor, Ra-reactive factor serine protease p100, complement factor MASP-3, complement-activating component of Ra-reactive factor, mannose-binding lectin-associated serine protease 1, mannose-binding protein-associated serine protease, serine protease 5
Species: human

Top Publications

  1. ncbi MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway
    M R Dahl
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000, Aarhus, Denmark
    Immunity 15:127-35. 2001
  2. ncbi Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
    V Rossi
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel CEA CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 276:40880-7. 2001
  3. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003
  4. ncbi Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Mette Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int Immunol 19:141-9. 2007
  5. doi The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Biochim Biophys Acta 1784:1294-300. 2008
  6. doi MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity
    József Dobó
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 183:1207-14. 2009
  7. doi Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function
    Márton Megyeri
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 183:3409-16. 2009
  8. doi MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    Søren E Degn
    Departments of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark
    J Immunol 183:7371-8. 2009
  9. pmc A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    Mikkel Ole Skjoedt
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:8234-43. 2010
  10. doi Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Arhus C, Denmark
    J Immunol Methods 361:37-50. 2010

Research Grants

  1. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
  2. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
  3. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
  4. VERNON MICHAEL HOLERS; Fiscal Year: 2016
  5. MASP-2 MoAB therapeutics for MI/RP injury
    CLARK TEDFORD; Fiscal Year: 2005
  6. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
  7. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
  8. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
  9. Development of MASP-2 MoAbs for the treatment of diabetic nephropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2010
  10. StcE, an E.coli O157:H7 Protease Specific for C1-Inh
    RODNEY WELCH; Fiscal Year: 2007

Detail Information

Publications184 found, 100 shown here

  1. ncbi MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway
    M R Dahl
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000, Aarhus, Denmark
    Immunity 15:127-35. 2001
    ..We present a phylogenetically highly conserved member of the MBL complex, MASP-3, which is generated through alternative splicing of the MASP-1/3 gene...
  2. ncbi Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
    V Rossi
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel CEA CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 276:40880-7. 2001
    Mannan-binding lectin (MBL)-associated serine proteases-1 and 2 (MASP-1 and MASP-2) are homologous modular proteases that each interact with MBL, an oligomeric serum lectin involved in innate immunity...
  3. ncbi Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    Geza Ambrus
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 170:1374-82. 2003
    Mannan-binding lectin-associated serine protease (SP) (MASP)-1 and MASP-2 are modular SP and form complexes with mannan-binding lectin, the recognition molecule of the lectin pathway of the complement system...
  4. ncbi Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Mette Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int Immunol 19:141-9. 2007
    ..lectin (MBL) promoted the activation of C3 through the combined action of MBL-associated serine protease (MASP)-1 and MASP-2 without appreciable involvement of the alternative pathway...
  5. doi The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Biochim Biophys Acta 1784:1294-300. 2008
    ..MASP1 only a few protein substrates which are cleaved at a low rate have been identified while none are known for MASP3. Since chromogenic substrate screenings have shown that MASP1 has thrombin-like activity, we wanted to investigate ..
  6. doi MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity
    József Dobó
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 183:1207-14. 2009
    Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 is an abundant component of the lectin pathway of complement. The related enzyme, MASP-2 is capable of activating the complement cascade alone...
  7. doi Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function
    Márton Megyeri
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 183:3409-16. 2009
    ..Mannose-binding lectin-associated serine protease-1 (MASP-1) is an abundant protease of the complement lectin pathway; however, its physiological function is unclear...
  8. doi MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    Søren E Degn
    Departments of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark
    J Immunol 183:7371-8. 2009
    ..We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1...
  9. pmc A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    Mikkel Ole Skjoedt
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:8234-43. 2010
    ..MASP-1 and MASP-3 (MASP1 isoforms 1 and 2, respectively) are splice variants of the MASP1 gene, whereas MASP-2 and sMAP are splice variants ..
  10. doi Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Arhus C, Denmark
    J Immunol Methods 361:37-50. 2010
    ..in complexes with MBL-associated serine proteases (MASP-1, -2 and -3) and two additional proteins (MAp19 and MAp44, also termed sMAP and MAP-1, respectively)...
  11. doi Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
    Andrea Kocsis
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    J Immunol 185:4169-78. 2010
    ..peptide inhibitors developed by phage display against mannose-binding lectin-associated serine proteases (MASPs), MASP-1 and MASP-2...
  12. pmc MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes
    Asli Sirmaci
    Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami, FL 33136, USA
    Am J Hum Genet 87:679-86. 2010
    ..In one family, whole exome sequencing revealed a missense mutation, MASP1 c.2059G>A (p.G687R), that cosegregated with the phenotype...
  13. pmc Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome
    Caroline Rooryck
    Molecular Medicine Unit, University College London Institute of Child Health, London, UK
    Nat Genet 43:197-203. 2011
    ..Here we studied 11 families with 3MC syndrome and identified two mutated genes, COLEC11 and MASP1, both of which encode proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 and MASP-3, ..
  14. pmc Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
    József Dobó
    Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e20036. 2011
    ..system activates after infection and oxidative stress on endothelial cells generating active serine proteases: MASP-1 and MASP-2. Our aim was to study whether activated MASPs are able to digest HK to release BK...
  15. pmc Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2
    Dávid Héja
    Department of Biochemistry, Eotvos Lorand University, 1 C Pázmány Péter Street, H 1117, Budapest, Hungary
    J Biol Chem 287:20290-300. 2012
    ..b>MASP-2 is considered as the autonomous pathway-activator, while MASP-1 is considered as an auxiliary component...
  16. pmc Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components
    S Thiel
    Department of Biomedicine, Aarhus University, Denmark
    Clin Exp Immunol 169:38-48. 2012
    ..Three proteins are produced from the MASP1 gene: MASP-1 and MASP-3 and MAp44. We present an assay specific for MASP-1, which is based on inhibition of the binding of anti-MASP-1-specific ..
  17. pmc Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
    Dávid Héja
    Department of Biochemistry, Eotvos Lorand University, H 1117 Budapest, Hungary
    Proc Natl Acad Sci U S A 109:10498-503. 2012
    ..Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)-2 has been considered the autonomous initiator of the proteolytic cascade...
  18. doi Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Immunol 189:3957-69. 2012
    ..study, we present functional studies based on a patient harboring a nonsense mutation in the common part of the MASP1 gene and hence deficient in both MASP-1 and MASP-3...
  19. pmc Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway
    Márton Megyeri
    Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 29 Karolina Street, H 1113 Budapest, Hungary
    J Biol Chem 288:8922-34. 2013
    Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have been thought to autoactivate when MBL/ficolin·MASP complexes bind to pathogens triggering the complement lectin pathway...
  20. ncbi Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin
    Monique Lacroix
    Institut de Biologie Structurale Jean Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique Commissariat à l Energie Atomique, Universite Joseph Fourier, Grenoble, France
    J Immunol 182:456-65. 2009
    ..They share with mannan-binding lectin (MBL) the ability to associate with MBL-associated serine proteases (MASP)-1, -2, -3, and protein MAp19 and to trigger the lectin complement pathway through MASP-2 activation...
  21. ncbi Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus
    H R Juul-Madsen
    Danish Institute of Agricultural Sciences, P O Box 50, DK 8830 Tjele, Denmark
    Poult Sci 82:235-41. 2003
    ..recognition domains, followed by direct opsonization or complement activation via MBL-associated serine proteases (MASP)-1 and -2. Thus, MBL plays a major role in the first-line innate defense against pathogens...
  22. doi Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:551-8. 2009
    ..Cord blood samples were analysed to determine mbl-2 gene variants, MBL concentrations and MBL-MASP-2 complex activities (MBL-dependent lectin pathway activity) as well as l-ficolin levels...
  23. ncbi C-type lectins and galectins mediate innate and adaptive immune functions: their roles in the complement activation pathway
    G R Vasta
    Center for Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore 21202, USA
    Dev Comp Immunol 23:401-20. 1999
    ..The recognition factor, MBL, is associated with a serine protease [MBL-associated serine protease (MASP)] which, upon MBL binding to the microbial ligand, activates the complement component C3, leading to either (a) ..
  24. doi Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:1696-701. 2009
    ..on the ability of these lectins to form complexes with MBL-associated serine proteases (MASPs), particularly MASP-2...
  25. ncbi The ancestry and cumulative evolution of immune reactions
    Jolanta M Dzik
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw University of Life Sciences, Warszawa, Poland
    Acta Biochim Pol 57:443-66. 2010
    ..complement system comprising at least the central molecule of the complement system, C3, Factor B, and MASP developed in the cnidarians and evolved into the multilevel cascade engaged in innate and acquired immunity of ..
  26. doi Evolutionary conservation of mannan-binding lectin (MBL) in bony fish: identification, characterization and expression analysis of three bona fide collectin homologues of MBL in the rainbow trout (Onchorhynchus mykiss)
    Per Walther Kania
    Department of Inflammation and Cancer Research, University of Southern Denmark, Odense, Denmark
    Fish Shellfish Immunol 29:910-20. 2010
    ..In the liver, we saw co-expression with mannan-binding lectin associated serine protease (MASP). The MBL homologues 2 and 3 (MBL-H2,3) were also found in the vascular system of the rainbow trout...
  27. ncbi Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality
    Henriette Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Clin Cancer Res 11:1441-6. 2005
    Mannan-binding lectin-associated serine protease 2 (MASP-2) is a plasma protein involved in inflammatory processes...
  28. doi Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer
    H Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Scand J Immunol 73:122-7. 2011
    Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2...
  29. doi Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 182:2939-47. 2009
    Mannan-binding lectin-associated serine protease 2 (MASP-2) is an enzyme of the innate immune system...
  30. ncbi The role of mannose-binding lectin in health and disease
    M W Turner
    Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Mol Immunol 40:423-9. 2003
    ..This activation is mediated by complexes of MBL with a serine protease called MBL-associated serine protease 2 (MASP-2), which specifically cleaves C4 and C2 to create a C3 convertase enzyme...
  31. ncbi Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer
    H Ytting
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Scand J Gastroenterol 39:674-9. 2004
    ..The MBL pathway was therefore evaluated in serum obtained preoperatively from 193 patients with primary CRC and in serum from 150 healthy volunteers...
  32. ncbi Mannose-binding lectin (MBL) in health and disease
    M W Turner
    Immunobiology Unit, Institute of Child Health, London, UK
    Immunobiology 199:327-39. 1998
    ..or more collectin receptors on phagocyte surface or may trigger the activation of a pro-serine protease complex (MASP 1 and MASP 2) leading to cleavage of C4 and C2 of the classical complement pathway...
  33. doi Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults
    M Isabel Garcia-Laorden
    Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
    J Allergy Clin Immunol 122:368-74, 374.e1-2. 2008
    ..Mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) deficiencies are common primary immunodeficiencies the clinical penetrance of which remains controversial...
  34. ncbi Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by C1-inhibitor and alpha 2-macroglobulin
    Sunita Gulati
    Section of Infectious Diseases and Hematology Oncology, Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 168:4078-86. 2002
    ..gonorrhoeae was achieved at a concentration of 0.3 microg/ml. Preopsonization with MBL-MASP at concentrations as low as 0...
  35. doi Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)
    Aina Zehnder
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Blood Cancer 53:53-7. 2009
    Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are key components of the lectin pathway of complement activation. Their serum concentrations show a wide interindividual variability...
  36. ncbi Assays for the functional activity of the mannan-binding lectin pathway of complement activation
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunobiology 205:446-54. 2002
    ..complement to occur MBL must be associated with serine proteases (MBL-associated serine proteases, MASPs) in an MBL/MASP complex...
  37. ncbi Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL
    N M Thielens
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat á l Energie Atomique Centre National de la Recherche Scientifique, Grenoble, France
    J Immunol 166:5068-77. 2001
    ..In human serum, two MBL-associated serine proteases (MASP-1, MASP-2) and MBL-associated protein 19 (MAp19) were found to be associated with MBL...
  38. doi A novel measurement method for activation of the lectin complement pathway via both mannose-binding lectin (MBL) and L-ficolin
    Hiroyuki Inoshita
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Immunol Methods 349:9-17. 2009
    ..L-ficolin and H-ficolin are human serum lectins, all of which form complexes with MBL-associated serine proteases (MASP)...
  39. ncbi A second serine protease associated with mannan-binding lectin that activates complement
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Nature 386:506-10. 1997
    ..C1 subcomponent, C1q, and seems to activate the complement system through an associated serine protease known as MASP (ref. 4) or p100 (ref. 5), which is similar to C1r and C1s of the classical pathway...
  40. ncbi Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms
    S Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Genes Immun 8:154-63. 2007
    ..When this happens MBL-associated serine protease-2 (MASP-2) is activated and cleaves complement factors to start inflammatory actions...
  41. ncbi MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway
    T Vorup-Jensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunobiology 199:348-57. 1998
    ..Until recently it was thought that only one serine protease in complex with MBL (MBL-associated serine protease, MASP) mediates complement activation, but with the finding of a second MBL-associated serine protease, MASP-2, the ..
  42. doi Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels
    Nannette Brouwer
    Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 183:3496-504. 2009
    ..The MBL-dependent MBL-associated serine protease (MASP)-mediated complement C3 and C4 activation also showed a suboptimal increase...
  43. ncbi The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin
    Lynn A Gregory
    Laboratoire de Cristallographie et Cristallogenese des Proteines, France
    J Biol Chem 279:29391-7. 2004
    MAp19 is an alternative splicing product of the MASP-2 gene comprising the N-terminal CUB1-epidermal growth factor (EGF) segment of MASP-2, plus four additional residues at its C-terminal end...
  44. ncbi The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
    Veronika Harmat
    Protein Modeling Group, Hungarian Academy of Sciences, Eotvos Lorand University, Pázmány Péter sétány 1A, H 1117 Budapest, Hungary
    J Mol Biol 342:1533-46. 2004
    ..the carbohydrate structures on pathogens, is activated by mannose-binding lectin-associated serine protease-2 (MASP-2). We present the 2...
  45. doi Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity
    Soren Hansen
    Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark
    J Immunol 185:6096-104. 2010
    ..Mannan-binding lectin-associated serine protease 1 (MASP-1) copurified with CL-11 and the interaction in plasma with MASP-1 and/or MASP-3 was further demonstrated using ..
  46. ncbi Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds
    Nicholas J Lynch
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 174:4998-5006. 2005
    ..recognition subunit (either mannan-binding lectin (MBL) or a ficolin), three MBL-associated serine proteases (MASP-1, -2, and -3), and MAp19 (a truncated product of the MASP-2 gene)...
  47. ncbi Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55
    Florence Teillet
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, Grenoble, France
    J Immunol 178:5710-6. 2007
    ..lectin that binds neutral carbohydrates on pathogens, forms complexes with MBL-associated serine proteases (MASP)-1, -2, and -3 and 19-kDa MBL-associated protein (MAp19), and triggers the complement lectin pathway through ..
  48. ncbi [Prokaryotic expression of N terminal fragment of mannan-binding lectin associated serine protease-1]
    Xue min Cai
    Department of Immunology, Southern Medical University, Guangzhou, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:546-9. 2008
    To express the N-terminal fragment of human mannan-binding lectin (MBL) associated serine proteases-1 (MASP1-N) in E.coli.
  49. pmc Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship
    M Carlsson
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Sweden
    Clin Exp Immunol 139:306-13. 2005
    ..Some genotypes result in low serum concentrations of MBL. MBL-associated serine protease 2 (MASP-2) is another protein belonging to the MBL pathway...
  50. ncbi The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases
    Florence Teillet
    Laboratoires d Enzymologie Moléculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l énergie atomique Centre National de La Recherche Scientifique Université Joseph Fourier, Grenoble, France
    J Immunol 174:2870-7. 2005
    ..It forms individual complexes with MBL-associated serine proteases (MASP)-1, -2, -3 and a truncated form of MASP-2 (MAp19) and triggers the lectin pathway of complement through MASP-2 ..
  51. ncbi The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier
    H V Olesen
    Department of Pediatrics A, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Clin Immunol 121:324-31. 2006
    ..is initiated by mannan-binding lectin (MBL) or the ficolins through the common MBL-associated serine protease-2 (MASP-2). Deficiency of MBL has been associated with poorer outcome in cystic fibrosis (CF)...
  52. ncbi Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007
    The lectin pathway of the complement system is activated when Mannan-binding lectin (MBL) in complex with MASP-2 binds microorganisms...
  53. ncbi Mannan-binding lectin (MBL) in women with tumours of the reproductive system
    A St Swierzko
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Łódź, Poland
    Cancer Immunol Immunother 56:959-71. 2007
    ..We investigated mbl2 genotypes, MBL concentrations, and MBL-MASP-2 complex activity in patients with ovarian cancer...
  54. pmc Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults
    Maciej Cedzynski
    Laboratory of Immunobiology of Infections, Center of Medical Biology, Polish Academy of Sciences, Łódź, Poland
    Arch Immunol Ther Exp (Warsz) 56:69-75. 2008
    ..C1-INH interacts with MASP-1 and MASP-2 proteases, participating in the mannan-binding lectin (MBL) pathway of complement activation...
  55. doi Ficolins: novel pattern recognition molecules of the innate immune response
    Valeria L Runza
    Institute of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Immunobiology 213:297-306. 2008
    ..were shown to associate with the lectin pathway-specific serine protease MBL-associated serine protease-2 (MASP-2) and catalyse its activation which in turn activates C4 and C4b-bound C2 to generate the C3 convertase C4b2a...
  56. pmc Influence of major surgery on the mannan-binding lectin pathway of innate immunity
    H Ytting
    Department of Surgical Gastroenterology 435, Hvidovre University Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Clin Exp Immunol 144:239-46. 2006
    ..effect of major surgery on two central components of the MBL pathway; MBL and the MBL-associated serine protease MASP-2, and for comparison also measured the interleukin (IL)-6 and C-reactive protein (CRP) levels...
  57. ncbi Second-generation nanofiltered plasma-derived mannan-binding lectin product: process and characteristics
    I Laursen
    Statens Serum Institut, Copenhagen, Denmark
    Vox Sang 92:338-50. 2007
    ..Following is a description of the development of a nanofiltered second-generation MBL product from Cohn fraction III, with the use of a new affinity matrix for MBL purification and the characteristics of this improved product...
  58. ncbi Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B
    D L Jack
    Immunobiology Unit, Institute of Child Health, London, United Kingdom
    J Immunol 160:1346-53. 1998
    ..and the subsequent activation of the two major isoforms of C4 (C4A and C4B) by an associated serine protease, MASP. The mutants lacked expression of the capsular polysaccharide (siaD-), the lipo-oligosaccharide (LOS) outer core ..
  59. ncbi Mannan-binding lectin (MBL) in chickens: molecular and functional aspects
    S B Laursen
    Department D, Odense University Hospital, DK 5000, Odense C, Denmark
    Dev Comp Immunol 24:85-101. 2000
    ..domains followed by direct opsonization or complement activation via the MBL associated serine proteases MASP-1 and MASP-2. In Aves (i.e...
  60. ncbi Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates
    Y Endo
    Department of Biochemistry, Fukushima Medical College, Japan
    J Immunol 161:4924-30. 1998
    Mannose-binding lectin-associated serine protease (MASP) is a newly identified member of the serine protease superfamily...
  61. ncbi A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
    Peter Gal
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, P O Box 7, Budapest H 1518, Hungary
    J Biol Chem 280:33435-44. 2005
    ..into the autoactivation of a multidomain serine protease: mannose-binding lectin-associated serine protease-2 (MASP-2), the first enzymatic component in the lectin pathway of complement activation...
  62. ncbi Regulation of in situ complement activation via the lectin pathway in patients with IgA nephropathy
    M Endo
    The 2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Nephrol 55:185-91. 2001
    The lectin pathway, which is initiated by mannose-binding lectin (MBL) and MBL-associated serine protease (MASP), is one of the possible routes to activate the complement cascade in immunoglobulin A (IgA) nephropathy...
  63. pmc Depressed activation of the lectin pathway of complement in hereditary angioedema
    L Varga
    3rd Department of Internal Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    Clin Exp Immunol 153:68-74. 2008
    ..In addition, the level of C1q, MBL, MBL-associated serine protease-2 (MASP-2), C4-, C3- and C1INH was measured by standard laboratory methods...
  64. ncbi Shark complement: an assessment
    S L Smith
    Department of Medical Laboratory Sciences, Florida International University, Miami 33199, USA
    Immunol Rev 166:67-78. 1998
    ..The isolation of a cDNA clone encoding a mannan-binding protein-associated serine protease (MASP)-1-like protein from the Japanese dogfish (Triakis scyllia) suggests the presence of a lectin pathway...
  65. pmc Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin
    Wei Chuan Chang
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Biochem Pharmacol 81:388-95. 2011
    ..These observations suggest that RCLs are more efficient in associating with MASP-2, which predominantly mediates the activity...
  66. ncbi Activation of the lectin complement pathway in Henoch-Schönlein purpura nephritis
    Satoshi Hisano
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Am J Kidney Dis 45:295-302. 2005
    ..The current study aims to elucidate the correlation between each complement pathway and clinicopathologic findings in patients with Henoch-Schonlein purpura nephritis (HSPN)...
  67. ncbi [Isolation of a field strain of Babesia bigemina (Piroplasma: Babesiidae) and establishment of in vitro culture for antigen production]
    Roger I Rodríguez-Vivas
    Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Yucatan
    Rev Biol Trop 55:127-33. 2007
    ..The Microaerophilus Stationary Phase (MASP) in vitro culture method was used to reactivate the parasite...
  68. ncbi Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations
    R Wallis
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 275:30962-9. 2000
    ..In order to investigate the mechanisms of MASP activation by MBP, the cDNAs of rat MASP-1 and -2 have been isolated, and portions encompassing the N-terminal CUB ..
  69. ncbi Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma
    Amit Verma
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Int J Cancer 118:2930-5. 2006
    Mannan-binding lectin-associated serine protease-2 (MASP-2) is a serine protease involved in the activation of lectin complement pathway...
  70. pmc Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
    Barbro Selander
    Institute of Laboratory Medicine, Section of Microbiology, Immunology, and Glycobiology, Lund University, Lund, Sweden
    J Clin Invest 116:1425-34. 2006
    ..and generation of classical pathway C3 convertase via cleavage of C4 and C2 by MBL-associated serine protease 2 (MASP-2)...
  71. pmc Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex
    K S Brown
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Clin Exp Immunol 147:90-8. 2007
    ..We undertook this study to investigate a possible relationship between disease progression and functional MBL/MASP-1 complex activity...
  72. ncbi Collectins and host defence
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    Novartis Found Symp 279:170-81; discussion 181-6, 216-9. 2006
    ..MBL-MASP-2 complexes activate complement, but the role of MBL-MASP-1 and MBL-MASP-3 complexes is not yet known...
  73. ncbi The effect of neo-rectal wall properties on functional outcome after colonic J-pouch-anal anastomosis
    Martijn P Gosselink
    Colorectal Research Group of the Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Int J Colorectal Dis 22:1353-60. 2007
    ..However, CPAA patients may have impaired continence despite adequate sphincter function. The present study was designed to identify those factors, which contribute to the functional outcome after a handsewn CPAA...
  74. ncbi Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients
    Luregn J Schlapbach
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 26:989-94. 2007
    Mannose-binding lectin-associated serine protease-2 (MASP-2) is an essential component of the lectin pathway of complement activation...
  75. pmc The complement system in schizophrenia
    Karine R Mayilyan
    Genes, Cognition and Psychosis Program IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
    Drug News Perspect 21:200-10. 2008
    ..Two studies on different subject cohorts showed increased MBL-MASP-2 activity in patients versus controls...
  76. doi Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
    I Hamad
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    Mol Immunol 46:225-32. 2008
    ..of PEG-mediated C4d elevation in C1q-depleted serum by the broad serine protease inhibitor Futhan and anti-MASP-2 antibodies as well as competitive studies with d-mannose and N-acetylglucosamine indicated a likely role for ..
  77. pmc Pyriform spidroin 1, a novel member of the silk gene family that anchors dragline silk fibers in attachment discs of the black widow spider, Latrodectus hesperus
    Eric Blasingame
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, USA
    J Biol Chem 284:29097-108. 2009
    ..MS/MS analysis also confirmed the presence of MaSp1 and MaSp2, two important components of dragline silks, anchored within the attachment disc materials...
  78. pmc Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Kazue Takahashi
    Developmental Immunology Program, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunobiology 216:96-102. 2011
    ..In this study, we demonstrate that MBL and MBL-associated serine protease (MASP)-1/3 together mediate coagulation factor-like activities, including thrombin-like activity...
  79. doi MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease
    Angelica B W Boldt
    Laboratório de Imunopatologia Molecular Hospital de Clínicas, Federal University of Parana, 80060 900, Curitiba, PR, Brazil
    Clin Immunol 140:63-70. 2011
    ..012, OR=13.54). CD haplotypes linked to the p.P126L and p.V377A variants were associated with reduced MASP-2 levels (P<0.0001) but not reduced MBL/MASP-2/C4 complexes...
  80. pmc Combining flagelliform and dragline spider silk motifs to produce tunable synthetic biopolymer fibers
    Florence Teulé
    Department of Biology, Utah State University, Logan, UT 84322 5305, USA
    Biopolymers 97:418-31. 2012
    The two Flag/MaSp 2 silk proteins produced recombinantly were based on the basic consensus repeat of the dragline silk spidroin 2 protein (MaSp 2) from the Nephila clavipes orb weaving spider...
  81. doi Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
    Renee C Duncan
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 49:593-600. 2012
    ..Cleavage of C4 by MASP-2, the initiating protease of the lectin pathway, is a crucial event in the activation of this pathway, preceding ..
  82. pmc Silk-silica composites from genetically engineered chimeric proteins: materials properties correlate with silica condensation rate and colloidal stability of the proteins in aqueous solution
    David J Belton
    Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK
    Langmuir 28:4373-81. 2012
    ..end of a 15-mer repeat of the 32 amino acid consensus sequence of the major ampullate dragline Spindroin 1 (Masp1) Nephila clavipes spider silk sequence ([SGRGGLGGQG AGAAAAAGGA GQGGYGGLGSQG](15)X)...
  83. doi Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1)
    Lana Selman
    Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Immunobiology 217:851-63. 2012
    ..Similar polymorphic associations were reported for the mannan-binding lectin-associated serine protease 3 (MASP-3), and falls into line with the observation that CL-11 is found in circulating complexes with MASP-1/3...
  84. doi Complement expression in retinal pigment epithelial cells is modulated by activated macrophages
    Chang Luo
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, BT12 6BA Belfast, UK
    Exp Eye Res 112:93-101. 2013
    ..The expression of other genes, including C1r, C2, C4, CFH, Masp1, C1INH, and C4BP in RPE cells was also increased by the supernatants of M1 and M2b macrophages; however, the ..
  85. pmc High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties
    Guankui Wang
    The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, 12850 E Montview Boulevard, Aurora, Colorado 80045, United States
    ACS Nano 8:12437-49. 2014
    ..in opsonization by complement component 3 (C3) and with the decrease in the binding of the lectin pathway factor MASP-2 in mouse serum, suggesting that cross-linking blocks the lectin pathway of complement...
  86. doi No Strong Relationship Between Components of the Lectin Pathway of Complement and Susceptibility to Pulmonary Tuberculosis
    James D Chalmers
    Tayside Respiratory Research Group, University of Dundee, Dundee, DD1 9SY, UK
    Inflammation 38:1731-7. 2015
    ..This study investigated serum levels and genotypes of MBL, Ficolin-2, Ficolin-3 and MASP-2 in 168 patients with pulmonary tuberculosis and 168 age/sex-matched controls...
  87. doi Dual Thermosensitive Hydrogels Assembled from the Conserved C-Terminal Domain of Spider Dragline Silk
    Zhi Gang Qian
    State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P R China
    Biomacromolecules 16:3704-11. 2015
    ..First, we found that recombinant C-terminal domain of major ampullate spidroin 1 (MaSp1) of the spider Nephila clavipes formed hydrogels when cooled to approximately 2 °C or heated to 65 °C...
  88. doi IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study
    Yang Yang
    PLA Kidney Therapeutic Center Integrated Traditional and Western Medicine, Beidaihe Sanatorium of Beijing Military Region, West Beach Road, No 4, Beidaihe District, Qinhuangdao, China
    Immunol Res 64:919-30. 2016
    ..Completed remission (CR) was a major clinical outcome. A series of complement ingredients (MASP-1/2, MBL, C3a, C5a, Factor B, Ba, Bb and C5b-9) were measured in the patients of bi-positivity and bi-negativity: (..
  89. doi Resonance assignment of an engineered amino-terminal domain of a major ampullate spider silk with neutralized charge cluster
    Daniel Schaal
    Lehrstuhl Biopolymere, Universitat Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany
    Biomol NMR Assign 10:199-202. 2016
    Spider dragline fibers are predominantly made out of the major ampullate spidroins (MaSp) 1 and 2...
  90. doi The pattern recognition molecule collectin-L1 in critically ill children
    Catherine Ingels
    Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, Leuven, Belgium
    Pediatr Res 80:237-43. 2016
    ..to the pediatric intensive care unit (PICU) of the mannan-binding lectin (MBL)-associated serine protease (MASP)-3 protein of the lectin pathway of complement activation have been associated with risk of infection and prolonged ..
  91. doi MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study
    Christine von Toerne
    Research Unit Protein Science, Helmholtz Zentrum Munchen German Research Center for Environmental Health GmbH, Ingolstaedter Landstraße 1, D 85764, Munchen, Germany
    Diabetologia 59:1882-92. 2016
    ..In order to elucidate the pathophysiological processes leading to type 2 diabetes, we aimed to identify protein biomarkers associated with prediabetes...
  92. ncbi [Correlation among serum MBL, MASP-2, HsCRP and C3 levels in rheumatoid arthritis]
    Si Chen
    1School of Basic Medicine, Lanzhou University, Lanzhou 730030, China 2Second Hospital of Lanzhou University, Lanzhou 730030, China E mail
    Nan Fang Yi Ke Da Xue Xue Bao 36:1340-1344. 2016
    ..To investigate the correlation among serum levels of manning-binding lectin (MBL), MBL-associated serine proteases-2 (MASP-2), complement C3 and high-sensitive C reactive protein (HsCRP) in patients with rheumatoid arthritis (..
  93. ncbi Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G
    Mikio Kuraya
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int Immunol 15:109-17. 2003
    ..tested using RT-PCR, a human glioma cell line, T98G, expressed high levels of H-ficolin/Hakata antigen, MASP1 and MASP3 mRNAs. Similar results were obtained in four other glioma lines...
  94. ncbi Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 175:6846-51. 2005
    ..Analysis of mutant MBL . MASP-2 complexes assembled from recombinant components shows that reduced complement activation by both mutant MBLs is ..
  95. ncbi The influence of innate immunity gene receptors polymorphisms in renal transplant infections
    Carlos Cervera
    Department of Infectious Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Transplantation 83:1493-500. 2007
    ..assess the influence of genetic variability of innate immune receptors (mannose-binding lectin [MBL], mannose-associated serine-protease-2 [MASP-2], and Toll-like receptors [TLR4]) in the risk of infections after a kidney transplantation.
  96. ncbi Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway
    Minoru Takahashi
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan
    J Immunol 180:6132-8. 2008
    ..In this study, a MASP-1- and MASP-3-deficient mouse model (MASP1/3(-/-)) was generated by a gene targeting strategy to investigate the roles of MASP-1 and MASP-3 in the lectin ..
  97. doi Prey type, vibrations and handling interactively influence spider silk expression
    S J Blamires
    Department of Life Sciences, Tunghai University, Taichung, Taiwan
    J Exp Biol 213:3906-10. 2010
    ..major ampullate (MA) silks vary in response to different prey, mostly via differential expression of two genes - MaSp1 and MaSp2 - although the spinning process exerts additional influence over the mechanical properties of silk...
  98. pmc Inducing β-sheets formation in synthetic spider silk fibers by aqueous post-spin stretching
    Bo An
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82070, USA
    Biomacromolecules 12:2375-81. 2011
    ..In this study, two recombinant proteins based on Nephila clavipes Major ampullate Spidroin 1 (MaSp1) consensus repeat sequence were expressed and spun into fibers...
  99. doi Electrostatic charges instigate 'concertina-like' mechanisms of molecular toughening in MaSp1 (spider silk) proteins
    Mahdi Pahlevan
    Laboratory of Paper Coating and Converting, Centre for Functional Materials, Abo Akademi University, Porthaninkatu 3, 20500 Turku, Finland
    Mater Sci Eng C Mater Biol Appl 41:329-34. 2014
    ..we further show that electrostatic charges instigate a molecular 'concertina-like' mechanism of deformation in MaSp1 protein, which effectively begins the toughening-up of dragline silk threads prior to insect-web contact.
  100. doi Functionalized spider silk spheres as drug carriers for targeted cancer therapy
    Anna Florczak
    Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan 61 866, Poland
    Biomacromolecules 15:2971-81. 2014
    ..Hybrids composed of Her2 binding peptides (H2.1 or H2.2) and bioengineered silk MS1 (based on the MaSp1 sequence from N. clavipes) were designed...
  101. doi Dragline silk: a fiber assembled with low-molecular-weight cysteine-rich proteins
    Thanh Pham
    Departments of Biology and Chemistry, University of the Pacific, Stockton, California 95211, United States
    Biomacromolecules 15:4073-81. 2014
    Dragline silk has been proposed to contain two main protein constituents, MaSp1 and MaSp2...

Research Grants18

  1. Mannose Binding Lectin in Neuroinflammation and NeuroAIDS
    Kumud K Singh; Fiscal Year: 2013
    ..Additionally, variant MBL2/MASP-2 alleles alter expression and function of MBL in CNS...
  2. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    ..groups, and initiates the lectin-dependent complement cascade by activating MBL- associated serine protease-2 (MASP-2)...
  3. MASP-2 Therapy for Macular Degeneration
    CLARK TEDFORD; Fiscal Year: 2007
    ..by applicant): The overall goal is to develop monoclonal antibody-based compounds capable of blocking human MASP-2 function as potential therapeutic agents for the treatment of age-related macular degeneration (AMD)...
  4. VERNON MICHAEL HOLERS; Fiscal Year: 2016
    ..for the development of pathologic injury by the activities of the MBL associated serum protease (MASP) protein MASP1 on pro-factor D, as well as define the role of the receptors for the chemotactic peptides C3a and C5a as compared ..
  5. MASP-2 MoAB therapeutics for MI/RP injury
    CLARK TEDFORD; Fiscal Year: 2005
    The overall goal is to develop monoclonal antibodies capable of blocking human MASP-2 function as potential therapeutic agents for myocardial ischemia/reperfusion injury...
  6. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
    ..The mechanism of MASP activation by MBP will be probed by determining the structure of a MASP fragment that contains full MBP-binding ..
  7. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
    ..Aim 1 will test the hypothesis that mutations in the collagen region of MBL alter binding interactions with MASP1 or MASP2 and result in dysfunctional complement activation and/or disruption of MBL-mediated phagocytosis...
  8. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The overall objective of the MASP-2 program is to develop a monoclonal antibody that blocks the function of MASP-2, in order to treat microvascular complications associated with diabetes...
  9. Development of MASP-2 MoAbs for the treatment of diabetic nephropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The long-term objective of this application is to develop a MASP-2 blocking monoclonal antibody as a therapeutic agent to prevent and treat complications of diabetes, namely diabetic nephropathy (DN)...
  10. StcE, an E.coli O157:H7 Protease Specific for C1-Inh
    RODNEY WELCH; Fiscal Year: 2007
    ..C l-Inh inhibits diverse proteases: Clr and Cls, MASP-1, MASP-2, kallikrein, FXIIa, FXIa, and plasmin. Deficiencies in Cl-Inh cause profound clinical syndromes...
  11. CYTOKINE MECHANISMS IN SYSTEMIC AUTOIMMUNITY
    Chaim Jacob; Fiscal Year: 2001
    ..NZM2410, the Stat4-/-.NZM2328 and the Stat6-/-.NZM2328, employing a marker-assisted selection protocol (MASP) strategy to accelerate and control the development of the desired congenic mice strains...
  12. A Comprehensive Outcome Scale for Outpatient Psychiatry
    Diane Young; Fiscal Year: 2003
    ..The Multidimensional Assessment of Symptoms and Psychosocial Functioning (MASP) is designed to assess symptom severity of the most commonly diagnosed DSM-IV Axis I disorders, as well as ..
  13. MASP-2: A Potential New Target for Treatment of Rheumatoid Arthritis
    Emma Moore; Fiscal Year: 2008
    ..The goal of the research proposed here is to determine whether MBL-associated serine protease (MASP-2), an essential component of the lectin-activated complement pathway, may be such [unreadable] a target...
  14. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..Possible applications of spider silk range from artificial ligaments and tendons to bandages for burns to composite materials for multiple applications. ..
  16. Office for Access to Biomedical Research and Training
    CHARLES BIGGER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Validation of topography-biased antibody libraries
    Sylvia Smith; Fiscal Year: 2005
    ..Furthermore, this study will lay the foundation for further development of highly specific and high affinity antibodies to a diverse array of toxins. ..
  18. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001
    ..abstract_text> ..