MAPK11

Summary

Gene Symbol: MAPK11
Description: mitogen-activated protein kinase 11
Alias: P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11, MAP kinase 11, MAP kinase p38 beta, mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, stress-activated protein kinase-2, stress-activated protein kinase-2b
Species: human

Top Publications

  1. ncbi Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
    Y Jiang
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:17920-6. 1996
  2. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
  3. ncbi Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization
    Niina Reunanen
    Centre for Biotechnology and Department of Medicinal Biochemistry, University of Turku, FIN 20520 Turku, Finland
    J Biol Chem 277:32360-8. 2002
  4. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
  5. doi The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha
    Sangita B Patel
    Department of Global Structural Biology, Merck Research Laboratory, Rahway, NJ 07065, USA
    Acta Crystallogr D Biol Crystallogr 65:777-85. 2009
  6. ncbi Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
    P A Eyers
    Department of Biochemistry, University of Dundee, UK
    Chem Biol 5:321-8. 1998
  7. ncbi The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
    W M Macfarlane
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 272:20936-44. 1997
  8. ncbi SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)
    S Lawler
    Department of Biochemistry, University of Dundee, UK
    FEBS Lett 414:153-8. 1997
  9. doi Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes
    Qinxi Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 283:11014-23. 2008
  10. pmc Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
    Kevin M Rice
    Department of Pharmacology, Physiology and Toxicology, Joan C, Edwards School of Medicine, Marshall University, Huntington, WV, USA
    Cardiovasc Diabetol 5:18. 2006

Research Grants

  1. Paul S Shapiro; Fiscal Year: 2016
  2. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
  3. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
  4. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
  5. p38alpha and beta MAP Kinases in Endothelial Cells
    Yan Lin Guo; Fiscal Year: 2005
  6. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
  7. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
  8. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
  9. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
  10. p53-independent Role of MDM2, TGFb Resistance and Cancer
    Peiqing Sun; Fiscal Year: 2006

Detail Information

Publications180 found, 100 shown here

  1. ncbi Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
    Y Jiang
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:17920-6. 1996
    ..Here we characterize a new MAP kinase, p38beta. p38beta is a 372-amino acid protein most closely related to p38...
  2. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  3. ncbi Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization
    Niina Reunanen
    Centre for Biotechnology and Department of Medicinal Biochemistry, University of Turku, FIN 20520 Turku, Finland
    J Biol Chem 277:32360-8. 2002
    ..It is conceivable that both modes of action play an important role in controlling the proteolytic phenotype of fibroblasts, e.g. in wound repair and tumor invasion...
  4. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38...
  5. doi The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha
    Sangita B Patel
    Department of Global Structural Biology, Merck Research Laboratory, Rahway, NJ 07065, USA
    Acta Crystallogr D Biol Crystallogr 65:777-85. 2009
    ..Of the four p38 isoforms known to date, two (p38alpha and p38beta) have been identified as targets for cytokine-suppressive anti-inflammatory drugs...
  6. ncbi Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
    P A Eyers
    Department of Biochemistry, University of Dundee, UK
    Chem Biol 5:321-8. 1998
    ..belongs to a class of pyridinyl imidazoles that inhibits the stress-activated protein (SAP) kinases SAPK2a/p38 and SAPK2b/p38 beta 2 but not other mitogen-activated protein kinase family members...
  7. ncbi The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
    W M Macfarlane
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 272:20936-44. 1997
    ..gene transcription were both prevented by SB 203580, a specific inhibitor of stress-activated protein kinase 2 (SAPK2, also termed p38 mitogen-activated protein kinase, reactivating kinase, CSBP, and Mxi2) but not by several other ..
  8. ncbi SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)
    S Lawler
    Department of Biochemistry, University of Dundee, UK
    FEBS Lett 414:153-8. 1997
    ..SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38beta, SAPK3/ERK6 or SAPK4. It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila...
  9. doi Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes
    Qinxi Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 283:11014-23. 2008
    p38alpha and p38beta MAPKs (mitogen-activated protein kinases) share about 80% of their protein sequence identity, but have quite different biological functions...
  10. pmc Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
    Kevin M Rice
    Department of Pharmacology, Physiology and Toxicology, Joan C, Edwards School of Medicine, Marshall University, Huntington, WV, USA
    Cardiovasc Diabetol 5:18. 2006
    ..On the basis of these findings, we hypothesized that diabetes may be associated with alterations in how veins "sense" and "respond" to altered mechanical loading...
  11. ncbi Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells
    P Negre-Aminou
    TNO Prevention and Health, Gaubius Laboratory, Zernikedreef 9, 2301 CE, Leiden, The Netherlands
    Biochem Pharmacol 61:991-8. 2001
    ..PDGF)-induced DNA synthesis, extracellular-regulated kinase 1/2 (ERK1/2), p38/stress-activated protein kinase 2 (SAPK2), RhoA and Rac1 activation...
  12. ncbi Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4
    Julie Laferriere
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, Canada G1R2J6
    Clin Exp Metastasis 21:257-64. 2004
    ..This interaction activates, in the cancer cells, the MAPK SAPK2/p38, which leads to their transendothelial migration (Laferrière et al., J Biol Chem 2001; 276: 33762)...
  13. pmc Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 380:19-30. 2004
    ..It is not blocked by SB 203580, which inhibits SAPK2a/p38alpha and SAPK2b/p38beta but not SAPK3/p38gamma, or by the ERK pathway inhibitor PD 184352...
  14. ncbi The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    Chryso Kanthou
    Tumour Microcirculation Group, Gray Cancer Institute, Mount Vernon Hospital, PO Box 100, Northwood, Middlesex HA6 2JR, UK
    Blood 99:2060-9. 2002
    ....
  15. pmc Nogo-B is a new physiological substrate for MAPKAP-K2
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 391:433-40. 2005
    ..phosphorylation is prevented by SB 203580, an inhibitor of SAPK2a (stress-activated protein kinase 2a)/p38a and SAPK2b/p38b, and does not occur in embryonic fibroblasts generated from SAPK2a/p38a-deficient mice...
  16. ncbi The role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages
    Concetta Crisafulli
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, Messina, Italy
    Shock 32:62-73. 2009
    ..In conclusion, our study demonstrates that the endogenous and exogenous PPAR-alpha ligands reduce the degree of macrophage inflammation caused by LPS/IFN-gamma stimulation...
  17. pmc Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
    A Cuenda
    Department of Biochemistry, University of Dundee, UK
    EMBO J 16:295-305. 1997
    ..stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF) in a similar manner to SAPK1 (also termed JNK) and SAPK2 (also termed p38, RK, CSBP and Mxi2)...
  18. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
    ..This phosphorylation is dependent on the kinase p38/SAPK2 and correlates with the activation of MAPKAP kinase 2 (MK2)...
  19. ncbi Intrinsically active variants of all human p38 isoforms
    Michal Avitzour
    Department of Biological Chemistry, The Wolfson Centre for Applied Structural Biology, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    FEBS J 274:963-75. 2007
    ..The four mammalian isoforms (p38alpha, p38beta, p38gamma, and p38delta) are coexpressed and coactivated in the same cells...
  20. ncbi Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
    A Cuenda
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 274:4341-6. 1999
    ..accompanied by a strong activation of p70 S6 kinase and the mitogen-activated protein kinase (MAPK) family member SAPK2/p38, without significant activation of p42 MAPK and only slight activation of SAPK1/JNK and protein kinase Balpha...
  21. ncbi Stress-induced glucose uptake in bovine chromaffin cells: a comparison of the effect of arsenite and anisomycin
    C Fladeby
    Department of Physiology, University of Bergen, Arstadveien 19, 5009, Bergen, Norway
    Biochim Biophys Acta 1452:313-21. 1999
    ..The selective inhibitor of stress-activated protein kinase 2 (SAPK2), SB 203580, inhibited completely anisomycin-induced glucose uptake but only partly suppressed uptake stimulated ..
  22. ncbi Paradoxical activation of Raf by a novel Raf inhibitor
    C A Hall-Jackson
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, The University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Chem Biol 6:559-68. 1999
    ..Raf is a proto-oncogene that is activated in response to growth factors or phorbol esters, and is thought to activate MAP kinase kinase-1 (MKK1) and hence the classical MAP kinase (MAPK) cascade...
  23. ncbi Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts
    Wissam H Faour
    Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:9536-46. 2005
    ..Initial studies confirmed that PGE2 induces egr-1 mRNA expression and protein synthesis by restricted SAPK2/p38 MAPK-dependent activating transcription factor-2 (ATF-2) dimer transactivation of the egr-1 promoter as judged ..
  24. ncbi The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells
    Ariel Quinones
    Department of General Surgery, ECHO Laboratory, Martin Luther University, D 06097, Halle, Germany
    Life Sci 72:2975-92. 2003
    ..treatment with the MAP kinase (MAPK) inhibitor SB203580, which specifically blocks the stress inducible p38/SAPK2 pathway, did not alter egr-1 induction...
  25. ncbi PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation
    Dominique Sawka-Verhelle
    Departments of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 279:17772-84. 2004
    ..differentiation and phosphorylation of CREB-1 and the related factor CREM-1 are stimulated by M-CSF in a SAPK2/p38-dependent manner...
  26. ncbi Dual enzyme-linked immunosorbent assay system for detection of endogenous kinase activities of mitogen- and stress-activated protein kinase-1/2
    Tsuyoshi Ishii
    GlaxoSmithKline K K, Tsukuba shi, Ibaraki, Japan
    Assay Drug Dev Technol 5:523-33. 2007
    ..Our established system is applicable to inhibitor screening and drug discovery related to MSK1/MSK2...
  27. ncbi Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway
    K Merienne
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France
    Oncogene 19:4221-9. 2000
    ..and activation of RSK2 is mediated by the MAPK/ERK pathway, but that the Stress-Activated Protein Kinase 2 (SAPK2)/p38 pathway is also involved...
  28. ncbi Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
    Laurent Lamalice
    Centre de recherche en cancérologie de l Université Laval, 9 rue McMahon, Quebec G1R 2J6, Canada
    J Biol Chem 281:34009-20. 2006
    ..that following VEGF treatment of endothelial cells, VEGFR-2 is phosphorylated on Tyr1214 upstream of the Cdc42-SAPK2/p38-MAPKAP K2 pathway...
  29. ncbi p38beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis
    Y L Guo
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 82:556-65. 2001
    ..Using adenovirus-mediated gene transfer technique, we further demonstrated that p38beta, but not p38alpha, is essential to protect the cells from TNF-alpha toxicity...
  30. ncbi Role of mitogen- and stress-activated kinases in ischemic injury
    Elaine A Irving
    Neurology CEDD, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK
    J Cereb Blood Flow Metab 22:631-47. 2002
    ..are those that use the extracellular signal-regulated kinase (ERK1/2) or the stress-activated protein kinase (p38/SAPK2 or JNK/SAPK) pathways...
  31. ncbi Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages
    Catherine Ropert
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Brazil
    J Immunol 171:1456-65. 2003
    ..These results indicate a critical role of p38/stress-activated protein kinase-2 and NF-kappaB-dependent phosphatase in macrophage hyporesponsiveness induced by microbial products that activate TLR2 and TLR4...
  32. ncbi Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes
    S M Davidson
    Departement de Biologie, Unité de Génétique Moléculaire, Ecole Normale Superieure, 46 rue d Ulm, Paris Cedex 05, 75230, France
    Dev Biol 218:146-60. 2000
    ..The phosphorylation of HSP25 by the p38/SAPK2 pathway is known to be important for certain of its functions...
  33. ncbi SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    S Mertens
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 383:273-6. 1996
    ..Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle...
  34. ncbi Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 409:57-62. 1997
    ..kinases SAPK1gamma (also called JNK1), SAPK2a (also called p38, RK, CSBPs, Mpk2 and Mxi2), SAPK2b (also called p38beta), SAPK3 (also called ERK6 and p38gamma) and SAPK4 phosphorylate tau at many serine/threonine-prolines, as ..
  35. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
    Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2)..
  36. ncbi Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27)
    J Landry
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Biochem Soc Symp 64:79-89. 1999
    Activation of the mitogen-activated protein kinase (MAP kinase) SAPK2 (stress-activated protein kinase 2) leads to the phosphorylation of several transcription factors and cytoplasmic proteins, and thereby presumably orchestrates ..
  37. ncbi Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38
    A S Lal
    Department of Biochemistry, University College London, Dundee, DD1 5EH, United Kingdom
    Biochem Biophys Res Commun 259:465-70. 1999
    ..acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38...
  38. ncbi Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics
    L H Cohen
    Gaubius Laboratory, TNO Prevention and Health, Leiden University, Leiden, The Netherlands
    Biochem Pharmacol 60:1061-8. 2000
    ..Their current and possible future application as therapeutics in cancer, restenosis, angiogenesis, and osteoporosis is briefly discussed...
  39. ncbi The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway
    M Vockerodt
    Klinik fur Innere Medizin I, Zentrum für Molekulare Medizin, Universitat zu Koln, D 50924 Cologne, Germany
    Virology 280:183-98. 2001
    ..kappa B-alpha only marginally impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM (a specific p38/SAPK2 inhibitor) led to reduced IL-10 expression...
  40. ncbi Activation of p38 mitogen-activated protein kinases by endothelin and noradrenaline in small arteries, regulation by calcium influx and tyrosine kinases, and their role in contraction
    J Ohanian
    Department of Medicine, University of Manchester, Manchester Royal Infirmary, Manchester, UK
    Arterioscler Thromb Vasc Biol 21:1921-7. 2001
    ..Both vasoconstrictors activated p38alpha and/or p38beta but not p38gamma or p38delta, leading to increased HSP kinase activity...
  41. ncbi Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia
    Chun Shu Piao
    Department of Anatomy, Inha University School of Medicine, 7 241 Shinheung dong, Jung Gu, Inchon 400 712, South Korea
    Brain Res Mol Brain Res 107:137-44. 2002
    ..Here we report the differential induction of p38 MAPK isoforms, p38alpha and p38beta, in the adult gerbil brain following transient global ischemia...
  42. ncbi Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid
    Min Young Lee
    Hormone Research Center, Chonnam National University, Kwangju, Korea
    Diabetes 51:3400-7. 2002
    ..that RA treatment potentiates ATF-2-dependent transactivation by inducing specific phosphorylation of ATF-2 by p38beta kinase...
  43. ncbi Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism
    Jin Chen
    Department of Medicine, Stanford University School of Medicine, and VA Palo Alto Health Care System, Palo Alto, CA 95616, USA
    J Invest Dermatol 119:1261-8. 2002
    ....
  44. ncbi Regulation of the metastatic process by E-selectin and stress-activated protein kinase-2/p38
    Julie Laferriere
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec, G1R 2J6, Canada
    Ann N Y Acad Sci 973:562-72. 2002
    ..We review here the roles played by the endothelial adhesive molecule E-selectin and by the motogenic stress-activated protein kinase-2 (SAPK2/p38) pathway of cancer cells in modulating transendothelial migration of cancer cells.
  45. pmc Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada
    Mol Biol Cell 14:1418-32. 2003
    ....
  46. ncbi Protein calorie restriction has opposite effects on glucose metabolism and insulin gene expression in fetal and adult rat endocrine pancreas
    M A Martin
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain
    Am J Physiol Endocrinol Metab 286:E542-50. 2004
    ..insulin gene expression, especially pancreatic duodenal homeobox-1 (PDX-1), stress-activated protein kinase-2 (p38/SAPK2), and phosphatidylinositol 3-kinase...
  47. ncbi Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression
    Mohiuddin M Taher
    Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA
    Mol Cell Biochem 254:289-97. 2003
    ..We conclude that the mechanism by which curcumin modulates UV activation of HIV-LTR gene expression mainly involves the inhibition of NF-kappaB activation...
  48. ncbi Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways
    Edward M Rosser
    MRC Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee, UKDD1 5EH
    Org Biomol Chem 2:142-9. 2004
    ..The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot ..
  49. ncbi Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells
    Feng Zhu
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 25:1847-52. 2004
    ..UVC-stimulated phosphorylation of ATF2 (Thr71) was to varying degrees prevented by a dominant negative mutant of p38beta kinase, c-Jun N-terminal kinase 1 (JNK1) or extracellular signal-regulated kinase 2 (ERK2)...
  50. ncbi Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin
    Jaime Melendez
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229, USA
    J Biol Chem 279:53516-23. 2004
    ..kinase inhibitor), or Csk (cellular negative regulator for Src), as well as dominant negative constructs for p38beta or MKP-1...
  51. ncbi Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia
    Chun Shu Piao
    Department of Anatomy, Inha University School of Medicine, Jung Gu Shinheung Dong 3rd St 7 241, 400 712 Inchon, Korea
    Exp Brain Res 163:421-9. 2005
    ..Furthermore, p38beta MAPK, an upstream kinase of MAPKAPK-2, which has been known to be involved in compensatory responses to stress, ..
  52. ncbi Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, Saint Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1044:227-40. 2005
    ..0 nmol U0126) did not suppress NMDA-induced cell death in the RGCL nor thinning of the IPL. These findings suggest that JNK and p38 are proapoptotic in NMDA-induced cell death in the RGCL, but not ERK...
  53. ncbi Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly
    P F T Cezar-de-Mello
    Departamento de Farmacologia e Psicobiologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Oncogene 25:122-9. 2006
    ..A concomitant impairment in stress-activated protein kinase (SAPK2/p38) phosphorylation suggests that ATL inhibition of VEGF-stimulated actin polymerization involves the SAPK2/p38 ..
  54. pmc Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428
    Mercedes Pozuelo Rubio
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 392:163-72. 2005
    ..While p42/p44 MAPK (mitogen-activated protein kinase), SAPK2 (stress-activated protein kinase 2)/p38 and PKC (protein kinase C) were all activated by PMA in HeLa cells, the ..
  55. pmc Determinants that control the specific interactions between TAB1 and p38alpha
    Huamin Zhou
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, China
    Mol Cell Biol 26:3824-34. 2006
    ..Furthermore, chimeric analysis with p38beta (which does not bind to TAB1) revealed a previously unidentified locus of p38alpha comprising Thr218 and Ile275 ..
  56. ncbi Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase
    Qin Huang
    Department of Endocrinology, Changhai Hospital, Shanghai 200433, People s Republic of China
    Endocrinology 148:81-91. 2007
    ..913; P < 0.0001). Further study demonstrated that diazoxide up-regulated Bcl-2 expression and p38beta MAPK, which expressed at very low levels due to the high glucose, but not c-jun N-terminal kinase and ERK...
  57. ncbi Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer
    Yuka Okada
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Biotechnol 25:233-7. 2007
    ..Ectopic expression of Mapk11 also complemented Mapk14 deficiency during placentation.
  58. ncbi The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
    Helene Plun-Favreau
    Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 9:1243-52. 2007
    ..We suggest that PINK1-dependent phosphorylation of HtrA2 might modulate its proteolytic activity, thereby contributing to an increased resistance of cells to mitochondrial stress...
  59. ncbi Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    Dorota Gabrys
    Department of Radiation Oncology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
    Int J Radiat Oncol Biol Phys 69:1553-62. 2007
    ..To investigate the effects of radiation on the endothelial cytoskeleton and endothelial monolayer permeability and to evaluate associated signaling pathways, which could reveal potential mechanisms of known vascular effects of radiation...
  60. pmc Analysis of the impact of ERK5, JNK, and P38 kinase cascades on each other: a systems approach
    Pandurangan Sundaramurthy
    Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India
    Bioinformation 3:244-9. 2009
    ..We have observered that, the transient activation of ERK5, JNK1 and P38beta kinase, and the persistent activation of JNK2, JNK3 and P38 delta kinase does not get affected due to the cross-..
  61. pmc p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice
    Andrew R Pogozelski
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e7934. 2009
    ..gene deletion in mice, we now show that p38gamma mitogen-activated protein kinase (MAPK), but not p38alpha and p38beta, is required for endurance exercise-induced mitochondrial biogenesis and angiogenesis, whereas none of the p38 ..
  62. doi Differential activation of p38MAPK isoforms by MKK6 and MKK3
    Gaëlle Remy
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Darwin 3, UAM Campus de Cantoblanco, 28049 Madrid, Spain
    Cell Signal 22:660-7. 2010
    All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family (p38alpha, p38beta, p38gamma and p38delta) are activated by dual phosphorylation in the TGY motif in the activation loop...
  63. doi Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin
    Huei Mei Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Cell Physiol 223:687-94. 2010
    ..SB203580 is an inhibitor of p38alpha and p38beta isoforms...
  64. ncbi p38alpha is required for ovarian cancer cell metabolism and survival
    Antonio Matrone
    Department of Translational Pharmacology, Laboratory of Signal dependent Transcription, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Int J Gynecol Cancer 20:203-11. 2010
    ..These effects are mediated by a switch from hypoxia-inducible factor 1alpha (HIF1alpha) to forkhead transcription factor O (FoxO)-dependent transcription...
  65. pmc Characterization of a novel MK3 splice variant from murine ventricular myocardium
    Nadège Moïse
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Cell Signal 22:1502-12. 2010
    ..p38alpha appears pro-apoptotic whereas p38beta is pro-hypertrophic...
  66. doi Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation
    Fiona A Lovett
    The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Endocrinology 151:4368-80. 2010
    ..and -gamma mRNA levels were most abundant in differentiating C2 cells with low/negligible contributions from p38beta and -delta, respectively...
  67. doi Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3
    Akira Nakao
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem Lett 20:4774-8. 2010
    ..in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034, 0...
  68. pmc TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α
    Giovanni Ferrari
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Cancer Res 10:605-14. 2012
    ..Therefore, these results show that TGF-β1 induces endothelial cell apoptosis by shifting VEGF signaling from the prosurvival p38β to the proapoptotic p38α...
  69. pmc p38β, A novel regulatory target of Pokemon in hepatic cells
    Zhe Chen
    Department of Chemistry, Tsinghua University, Beijing 100084, China
    Int J Mol Sci 14:13511-24. 2013
    ..Both dual luciferase report assay and ChIP assay suggested that p38β is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells. ..
  70. pmc The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation
    Hisaka Kurita
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, College of Medicine, 3223 Eden Avenue, Cincinnati, OH 45267
    Toxicol Sci 139:121-32. 2014
    ..IκB kinase α (IKKα), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells ..
  71. pmc Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes
    Mohitkumar R Gangwani
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, Missouri, United States of America
    PLoS ONE 10:e0135633. 2015
    ..Understanding the molecular pathways involved in the HIV-1 neuroinflammation would be helpful in the design of adjunct therapy to ameliorate some of the symptoms associated with HIV-1 neuropathogenesis. ..
  72. pmc SUMO-Enriched Proteome for Drosophila Innate Immune Response
    Mithila Handu
    Indian Institute of Science Education and Research, Pune, India
    G3 (Bethesda) 5:2137-54. 2015
    ..These include components of immune signaling pathways such as Caspar, Jra, Kay, cdc42, p38b, 14-3-3ε, as well as cellular proteins with diverse functions, many being components of protein complexes, such as ..
  73. doi The protein phosphatase 2C clade A protein OsPP2C51 positively regulates seed germination by directly inactivating OsbZIP10
    Nikita Bhatnagar
    Gene Engineering Division, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, South Korea
    Plant Mol Biol . 2016
    ..Furthermore, interactions were observed between OsPP2C51 and SAPK2, and between OsPP2C51 and OsbZIP10 and we found out that OsPP2C51 can dephosphorylates OsbZIP10...
  74. pmc Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    H Enslen
    Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO J 19:1301-11. 2000
    The p38 mitogen-activated protein kinase (MAPK) group is represented by four isoforms in mammals (p38alpha, p38beta2, p38gamma and p38delta)...
  75. ncbi Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells
    H T Nguyen
    The Urologic Laboratory, Department of Urology, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 279:C1155-67. 2000
    ..Inhibitors of the p38 SAPK2 pathway, the angiotensin receptor type 1 (AT1), and the ErbB2 tyrosine kinase reduced each of these activities, ..
  76. ncbi Mitogen-activated protein kinases are in vivo transducers of osmosensory signals in fish gill cells
    D Kultz
    The Whitney Laboratory, University of Florida, 9505 Ocean Shore Boulevard, 32080, St Augustine, FL, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:821-9. 2001
    ..stress-activated protein kinase 1/ Jun N-terminal kinase (SAPK1), and stress-activated protein kinase 2/ p38 (SAPK2), were measured in gill epithelium of the euryhaline teleost Fundulus heteroclitus exposed for 1 h to 4 weeks to ..
  77. ncbi Tumor cell differentiation by butyrate and environmental stress
    O Witt
    Children s Hospital, University of Gottingen, Robert Koch Street 40, D 37075 Gottingen, Germany
    Cancer Lett 171:173-82. 2001
    ..Stress signaling pathways might be an interesting pharmacologic target for differentiation therapy of malignant disease...
  78. ncbi EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    H M Rosenfeldt
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, D C 20007, USA
    FASEB J 15:2649-59. 2001
    ..These results may also shed light on the vital role of EDG-1 in vascular maturation...
  79. ncbi Signalling pathways in cardiac myocyte hypertrophy
    P H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Ann Med 33:611-22. 2001
    ..signal-regulated kinase (ERK) cascade, the c-Jun N-terminal kinase (JNK or SAPK1) cascade, and the p38-MAPK (SAPK2-5) cascade...
  80. ncbi Proximal events in signaling by plasma membrane estrogen receptors
    Mahnaz Razandi
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, California 90822, USA
    J Biol Chem 278:2701-12. 2003
    ..E2 also induced AKT up-regulation in MCF-7 cells and p38beta MAP kinase activity in endothelial cells, blocked by an MMP inhibitor, GM6001, and tyrphostin AG1478...
  81. ncbi Activation of p38 MAPK suppresses matrix metalloproteinase-1 gene expression induced by platelet-derived growth factor
    Hideharu Endo
    Department of Clinical Biology of Extracellular Matrix F7, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Japan
    Arch Dermatol Res 294:552-8. 2003
    ..Overexpression of p38beta2, but not of p38alpha, significantly decreased PDGF-BB-induced MMP-1 promoter activity, although PDGF-BB activated ..
  82. ncbi T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3'-untranslated region of COX-2 mRNA
    Wissam H Faour
    Molecular Biology Program, University of Montreal, Quebec, Canada
    J Biol Chem 278:26897-907. 2003
    ..This response was mediated entirely by the stress-activated protein kinase 2/p38 cascade. As such, IL-17 can exert direct transcriptional and post-transcriptional control over target proinflammatory cytokines and oncogenes...
  83. pmc Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy
    Kojo S J Elenitoba-Johnson
    Department of Pathology, Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 100:7259-64. 2003
    ..Notably, growth factor cytokine receptors and p38beta-mitogen-activated protein kinase (MAPK) were differentially expressed in the DLBCLs...
  84. ncbi Soluble fractalkine prevents monocyte chemoattractant protein-1-induced monocyte migration via inhibition of stress-activated protein kinase 2/p38 and matrix metalloproteinase activities
    Sebastien Vitale
    Institut National de la Sante et de la Recherche Medicale, Unité 364, Institut Federatif de Recherche 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    J Immunol 172:585-92. 2004
    ..In this study, we found that stress-activated protein kinase (SAPK)1/c-Jun N-terminal kinase 1 and SAPK2/p38 are involved in the control of MCP-1-induced MonoMac6 cell migration...
  85. pmc Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
    Shahab Uddin
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:147-52. 2004
    p38alpha, p38beta, p38gamma, and p38delta are four isoforms of p38 mitogen-activated protein (MAP) kinase (MAPK) involved in multiple cellular functions such as cell proliferation, differentiation, apoptosis, and inflammation response...
  86. ncbi Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells
    Thomas P Kenny
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:255-63. 2004
    ..and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2. These inhibitory effects were observed when HAECs were treated with the flavonol fraction (molecular weight 280 ..
  87. ncbi Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways
    Guohu Li
    Center for Perinatal Biology, Department of Pharmacology and Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Pharmacol Exp Ther 312:112-9. 2005
    ..In contrast, the p38beta MAPK and mitogen-activated protein kinase kinase/ERK inhibitors SB 202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-..
  88. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation...
  89. ncbi 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice
    M Vilatoba
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Transplant Proc 37:399-403. 2005
    ..JNK and p38alpha activation have been associated with apoptosis; p38beta with cell survival; and ERK with proliferation...
  90. ncbi STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
    U Holtick
    Universitat zu Koln, Klinik fur Innere Medizin I, Koln, Germany
    Leukemia 19:936-44. 2005
    ..AG17 treatment was accompanied by decreased levels of STAT3 phosphorylation, whereas NF-kappaB and p38/SAPK2 signaling were not inhibited...
  91. ncbi Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity
    C N Antonescu
    Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Endocrinology 146:3773-81. 2005
    ..This observation suggested that insulin may increase GLUT4 activity via p38alpha and/or p38beta. Here we further explore the possible participation of p38MAPK through a combination of molecular strategies...
  92. pmc Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
    Hong Pyo Kim
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 102:11319-24. 2005
    ..b>p38beta-/- fibroblasts did not induce caveolin-1 in response to CO, and exhibited a diminished basal caveolin-1 ..
  93. pmc Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes
    Hideya Mizuno
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:1-9. 2006
    ..These results suggest that extracellular-signal regulated kinase (ERK), JNK, or p38 are implicated in EGF-induced neoplastic transformation of human cells...
  94. ncbi Dysregulation of the endothelial cellular response to oxidative stress in cancer
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, Quebec, Canada
    Mol Carcinog 45:362-7. 2006
    ..activation of the extracellular-signal regulated kinase (ERK) and the stress-activated protein kinase-2/p38 (SAPK2/p38) pathways...
  95. ncbi Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis
    Anne T Funding
    Department of Dermatology, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    J Invest Dermatol 127:2012-9. 2007
    ..Our results indicate that the p38-MAPK/MSK1/MSK2 and CREB signalling pathway may play a role in the pathogenesis of psoriasis...
  96. ncbi Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood
    Hadar Arien-Zakay
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Mol Neurosci 32:179-91. 2007
    ..of the mitogen-activated protein kinases ERK2 (36-fold vs control), p38alpha (nine-fold vs control) and p38beta (23-fold vs control), most likely related to survival and/or differentiation...
  97. doi MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation
    T Lin
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    Toxicology 247:145-53. 2008
    ..Similar results were obtained with siRNA against two isoforms of p38 MAPK, p38alpha and p38beta. Wortmannin, selective inhibitor of DNA-PK and ATM/ATR, abolished p53 phosphorylation, indicating an involvement ..
  98. pmc Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase
    Eriko Ohnishi
    Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 30:675-83. 2010
    ..In Xenopus laevis embryos, depletion of either p38beta or NLK by antisense morpholino oligonucleotides results in a severe defect in anterior development and impaired ..
  99. pmc Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells
    Takahiko Kogai
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 287:3292-300. 2012
    ..Targeting isoform-selective activation of p38 may enhance NIS induction, resulting in higher efficacy of (131)I concentration and treatment of breast cancer...
  100. pmc SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells
    Zhe Wang
    Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e31809. 2012
    ..Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact...
  101. pmc Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster
    Jeerang Wongtrakul
    Research Institute for Health Sciences, Chiang Mai University, POBOX 80 CMU, Chiang Mai, Thailand 50200
    J Insect Sci 12:107. 2012
    ..The p38b mitogen-activated protein kinase is involved in cellular stress response...

Research Grants17

  1. Paul S Shapiro; Fiscal Year: 2016
    ..We expect that these findings will have wider applications in mitigating inflammation and injury in other tissues as well. ..
  2. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
    ..g. p38alpha and p38beta, serves as a crucial determinant of myocyte fate...
  3. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..in our lab; (b) western blots from traumatized brain show activation of the MAP kinase pathways ERK and SAPK2/p38; (c) the ERK/MAP kinase pathway upregulates MMP in vitro; (d) MMP activation occurs after trauma in vivo; (e) ..
  4. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
    ..objective is to determine if the p38 kinase that is activated during hypoxia tolerance corresponds to p38alpha, p38beta, p38gamma, or p38delta...
  5. p38alpha and beta MAP Kinases in Endothelial Cells
    Yan Lin Guo; Fiscal Year: 2005
    ..The goal of this research is to investigate the roles for p38alpha and p38beta, two major isoforms expressed in endothelial cells (ECs), in the regulation of EC activities involved in ..
  6. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  7. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  8. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ....
  9. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  10. p53-independent Role of MDM2, TGFb Resistance and Cancer
    Peiqing Sun; Fiscal Year: 2006
    ..These studies will not only offer insights into the diverse pathways leading to the loss of TGFbeta sensitivity in tumors, but also reveal novel roles of MDM2 in tumorigenesis. ..
  11. REGULATION OF CELL ACTIVITIES BY COLLAGEN AND FIBRIN
    Jiahua Xu; Fiscal Year: 2004
    ..abstract_text> ..
  12. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  13. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  14. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2008
    ..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
  15. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2008
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
  16. EXTRACELLULAR MATRIX SIGNALING IN WOUND HEALING
    Jiahua Xu; Fiscal Year: 2002
    ....
  17. 67 KD LAMININ BINDING PROTEIN ON HUMAN T LYMPHOCYTES
    Stephen Canfield; Fiscal Year: 2003
    ..of p67 LBP and the integrin alpha6 to lymphocyte laminin-specific adherence? and (4) What are the contributions of p67 LBP and alpha6 to laminin-mediated lamellipod formation, locomotion, and transendothelial migration? ..