MAP3K8

Summary

Gene Symbol: MAP3K8
Description: mitogen-activated protein kinase kinase kinase 8
Alias: AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, mitogen-activated protein kinase kinase kinase 8, Ewing sarcoma transformant, augmented in rheumatoid arthritis 2, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2
Species: human

Top Publications

  1. pmc Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
    J Miyoshi
    Department of Oncogene Research, Osaka University, Japan
    Mol Cell Biol 11:4088-96. 1991
  2. ncbi The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
    M Aoki
    Department of Oncogene Research, Osaka University, Japan
    J Biol Chem 268:22723-32. 1993
  3. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
  4. ncbi Cot kinase regulation of IL-2 production in Jurkat T cells
    A Ballester
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina Universidad Autonoma de Madrid, Spain
    J Immunol 159:1613-8. 1997
  5. ncbi Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner
    A Ballester
    Instituto de Investigaciones Biomedicas, CSIC, Facultad Medicina Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 273:14099-106. 1998
  6. ncbi TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
    M P Belich
    Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, UK
    Nature 397:363-8. 1999
  7. pmc Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation
    M Chiariello
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 20:1747-58. 2000
  8. pmc Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
    Lawrence P Kane
    Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:5962-74. 2002
  9. pmc NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
    S Beinke
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 23:4739-52. 2003
  10. pmc ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
    V Lang
    Division of Immune Cell Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Mol Cell Biol 24:5235-48. 2004

Research Grants

  1. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
  2. Physician Monitoring System for Nicotine and Metabolites
    BADAWI M DWEIK; Fiscal Year: 2012
  3. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
  4. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
  5. Jason David Allen; Fiscal Year: 2014
  6. Tpl2 in Intestinal Tumorigenesis
    Philip N Tsichlis; Fiscal Year: 2013
  7. TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE
    ANIRUDDHA PUNTAMBEKAR; Fiscal Year: 2010
  8. Wendy T Watford; Fiscal Year: 2016
  9. MAP3K8-mediated regulation of adaptive immune responses and autoimmunity
    Wendy T Watford; Fiscal Year: 2012
  10. Musculoskeletal Diagnoses Cohort: Examining Pain and Pain Care in the VA
    Robert D Kerns; Fiscal Year: 2013

Detail Information

Publications240 found, 100 shown here

  1. pmc Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
    J Miyoshi
    Department of Oncogene Research, Osaka University, Japan
    Mol Cell Biol 11:4088-96. 1991
    ..from hamster SHOK cells transformed with DNA extracted from a human thyroid carcinoma cell line and named the cot (cancer Osaka thyroid) oncogene...
  2. ncbi The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
    M Aoki
    Department of Oncogene Research, Osaka University, Japan
    J Biol Chem 268:22723-32. 1993
    The cot gene is an oncogene encoding serine/threonine kinases isolated by DNA transfection assay...
  3. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
    ..Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1...
  4. ncbi Cot kinase regulation of IL-2 production in Jurkat T cells
    A Ballester
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina Universidad Autonoma de Madrid, Spain
    J Immunol 159:1613-8. 1997
    ..b>cot is a very closely related gene, if not the human homologue...
  5. ncbi Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner
    A Ballester
    Instituto de Investigaciones Biomedicas, CSIC, Facultad Medicina Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 273:14099-106. 1998
    b>Cot kinase is a protein serine/threonine kinase, classified as a mitogen-activated protein kinase kinase kinase, implicated in T lymphocyte activation...
  6. ncbi TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
    M P Belich
    Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, UK
    Nature 397:363-8. 1999
    ..a carboxy-terminal-deleted form, as an oncoprotein in rats and is more than 90% identical to the human oncoprotein COT. Expression of TPL-2 results in phosphorylation and increased degradation of p105 while maintaining p50 production...
  7. pmc Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation
    M Chiariello
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 20:1747-58. 2000
    The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family implicated in cellular transformation...
  8. pmc Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
    Lawrence P Kane
    Department of Medicine The Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:5962-74. 2002
    The Akt (or protein kinase B) and Cot (or Tpl-2) serine/threonine kinases are associated with cellular transformation. These kinases have also been implicated in the induction of NF-kappa B-dependent transcription...
  9. pmc NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
    S Beinke
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 23:4739-52. 2003
    Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus...
  10. pmc ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
    V Lang
    Division of Immune Cell Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Mol Cell Biol 24:5235-48. 2004
    ..Thus, optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105. Together, these data raise the possibility that ABIN-2 functions in the TLR4 signaling pathway which regulates TPL-2 activation...
  11. ncbi Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity
    Brenda S Luciano
    Department of Molecular Inflammation, Inflammation Signaling, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 279:52117-23. 2004
    Cot/Tpl2/MAP3K8 is a serine/threonine kinase known to activate the ERK, p38, and JNK kinase pathways...
  12. pmc Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity
    Hong Seok Choi
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    FASEB J 22:113-26. 2008
    ..The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family...
  13. ncbi Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
    J Perry Hall
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:33295-304. 2007
    ..b>Tpl2 is a MAPKKK in the MAPK (i.e...
  14. doi TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
    Activation of the TPL2-MKK1/2-ERK1/2 signalling pathway is essential for lipopolysaccharide (LPS)-stimulated production of TNF alpha in macrophages...
  15. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically expressed serine-threonine kinase...
  16. doi IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2
    Hosea Handoyo
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 424:109-18. 2009
    The protein kinase Tpl2 (tumour progression locus 2) is activated by LPS (lipopolysaccharide), TNFalpha (tumour necrosis factor alpha) and IL (interleukin)-1...
  17. pmc COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    Cory M Johannessen
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 468:968-72. 2010
    ..We identified MAP3K8 (the gene encoding COT/Tpl2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAF(V600E) ..
  18. pmc The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2
    Aristides G Eliopoulos
    The Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 76:4567-79. 2002
    ..In this study, we have identified the oncogenic kinase Tpl-2/Cot as a novel component of LMP1-induced NF-kappaB signaling...
  19. doi Evaluation of the phototoxic potential of plants used in oriental medicine
    Ki Min Bark
    Department of Chemical Education and Research Institute of Life Science, Gyeongsang National University, Jinju, 660 701, South Korea
    J Ethnopharmacol 127:11-8. 2010
    ..Phototoxicity can be either harmful or beneficial. Yet the phototoxicity of oriental medicinal plants is an understudied area. The purpose of this study is to fill in this gap...
  20. ncbi Effect of a sudden infant death syndrome risk reduction education program on risk factor compliance and information sources in primarily black urban communities
    Kenneth A Rasinski
    National Opinion Research Center at the University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 111:e347-54. 2003
    ..The continued racial disparity in SIDS is thought to be attributable to lack of compliance with SIDS risk reduction recommendations...
  21. ncbi Transposon tagging and the study of root development in Arabidopsis
    R Tsugeki
    Biotechnology Institute, The Pennsylvania State University, University Park, USA
    Gravit Space Biol Bull 11:79-87. 1998
    ..A gene expressed in root cap cells tagged with an enhancer-trap Ds was isolated and its corresponding EST cDNA was identified...
  22. ncbi Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Vejle, Denmark
    Thromb Res 98:233-9. 2000
    Sudden infant death syndrome or "cot death" has until the late eighties been a significant cause of death in children between the ages of 1 month and 1 year...
  23. ncbi Skin-to-skin care with the father after cesarean birth and its effect on newborn crying and prefeeding behavior
    Kerstin Erlandsson
    Department of Woman and Child Health, Division of Reproductive and Perinatal Health, Karolinska Institutet, Stockholm, Sweden
    Birth 34:105-14. 2007
    ..of skin-to-skin contact on crying and prefeeding behavior in healthy, full-term infants born by elective cesarean birth and cared for skin-to-skin with their fathers versus conventional care in a cot during the first 2 hours after birth.
  24. pmc Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    J Lingner
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Proc Natl Acad Sci U S A 94:11190-5. 1997
    ..Previous characterization of yeast telomerase function in vivo identified four EST (for ever shorter telomeres) genes that, when mutated, result in the phenotypes expected for a defect in telomerase...
  25. ncbi Regulation of K-Cl cotransport: from function to genes
    N C Adragna
    Department of Pharmacology, Wright State University, School of Medicine, Dayton, OH 45435 0002, USA
    J Membr Biol 201:109-37. 2004
    This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation from a functional and genetic viewpoint...
  26. ncbi Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
    Katie J Loniewski
    Division of Pathology, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 44:3715-23. 2007
    ..7, a mouse macrophage cell line. ERK activation in macrophages by TLR4 and -7 is mediated via a MAP3K, called TPL2/COT, which under unstimulated conditions is associated with NF kappa B1 p105, a member of the I kappa B family of ..
  27. ncbi Circadian rhythms and enhanced athletic performance in the National Football League
    R S Smith
    Stanford University Sleep Disorders Clinic, CA 94305, USA
    Sleep 20:362-5. 1997
    ..m. Eastern Standard Time (EST) from the 1970-1994 seasons...
  28. pmc Characterization of cotJ, a sigma E-controlled operon affecting the polypeptide composition of the coat of Bacillus subtilis spores
    A O Henriques
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Bacteriol 177:3394-406. 1995
    ..Studies with double-reporter strains bearing a cotJ-gusA fusion and lacZ fusions to other cot genes confirmed that expression of cotJ is initiated during sporulation prior to activation of genes known to ..
  29. ncbi Treatment patterns in elderly patients (greater than or equal to 70 years) with breast carcinoma. A retrospective study of the Gruppo Oncologico Clinico Cooperativo del nord-Est (GOCCNE)
    D Crivellari
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 77:136-40. 1991
    ..Comorbid conditions are of particular concern in therapy planning, considering that more stage III patients died of competing causes than for disease progression. The role of chemotherapy was very marginal...
  30. doi Practice variation in the transfer of premature infants from incubators to open cots in Australian and New Zealand neonatal nurseries: results of an electronic survey
    Karen New
    The University of Queensland, School of Nursing and Midwifery, Royal Brisbane and Women s Hospital, Butterfield Street, Brisbane, Queensland 4029, Australia
    Int J Nurs Stud 47:678-87. 2010
    ..of the premature infant but the infant is ultimately required to make a successful transfer from incubator to open cot in order to be discharged from hospital...
  31. doi The beginnings of modern psychiatric treatment in Europe. Lessons from an early account of convulsive therapy
    Brigitta Baran
    Dept of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Eur Arch Psychiatry Clin Neurosci 258:434-40. 2008
    Convulsive therapy (COT) is a major European contribution to the psychiatric armamentarium and biological psychiatry. COT was introduced in psychiatry by László Meduna, a Hungarian neuropsychiatrist...
  32. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI...
  33. pmc Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion
    A Makris
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 67:4283-9. 1993
    ..Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity...
  34. ncbi Who's got what? A benchmarking exercise for tertiary neonatal units
    C A Kuschel
    Newborn Services, National Women s Health, Auckland District Health Board, Auckland, New Zealand
    J Paediatr Child Health 41:635-9. 2005
    ..To determine the current facilities available in level-3 neonatal units (NNU) in Australia and New Zealand to assist with establishment of standards for new NNU design...
  35. pmc The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors
    K H Ruan
    Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
    Biochem J 274:849-54. 1991
    ..electric ray) and human acetylcholine receptors (AChR) were localized by reaction of 125I-labelled cobrotoxin (Cot) and erabutoxin b (Eb) with synthetic overlapping peptides spanning the entire extracellular part of the respective ..
  36. ncbi Antibiotic resistance of Salmonella enterica serovar Paratyphi A in India: emerging and reemerging problem
    Shyamapada Mandal
    Department of Bacteriology and Serology, Calcutta School of Tropical Medicine, C R Avenue, Kolkata 700073, India
    J Postgrad Med 52:163-6. 2006
    ..Antibiotic resistance pattern and R-plasmid of Salmonella enterica serovar Paratyphi A isolates from Kolkata, India are not well documented...
  37. ncbi High-performance liquid chromatographic assay for N-glucuronidation of nicotine and cotinine in human liver microsomes
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa, 920 0934, Japan
    Anal Biochem 302:131-5. 2002
    ..The nicotine N-glucuronide (Nic-glu) and cotinine N-glucuronide (Cot-glu) formed were analyzed by ion-pair chromatography with a C-18 column...
  38. pmc Reducing medication errors in the neonatal intensive care unit
    J H Simpson
    Paediatric Department, Princess Royal Maternity Hospital, Glasgow G31 2ER, Scotland, UK
    Arch Dis Child Fetal Neonatal Ed 89:F480-2. 2004
    ..Medication errors are common in the neonatal intensive care unit (NICU). Various strategies to reduce errors have been described in adult and paediatric patients but there are few published data on their effect in the NICU...
  39. doi Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone
    Emirhan Nemutlu
    Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Sihhiye, Ankara, Turkey
    Talanta 80:117-26. 2009
    ..of seven cephalosporins [Cefepime (CEP), ceftazidime (CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and cefoperazone (COP)] in human plasma and amniotic fluid has been developed...
  40. pmc Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
    T Kato
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Glia 30:209-18. 2000
    ..Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1-positive cells and OEC nuclei within the repaired lesion...
  41. ncbi Occurrence of Escherichia coli O157 in raw material and food in Czech Republic
    J Lukásová
    Department of Milk Hygiene and Technology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, The Czech Republic
    J Vet Med B Infect Dis Vet Public Health 51:77-81. 2004
    ..GEN), colistin (COL), cephalozine (CLZ), cefoxitin (CXT), aztreonam (AZT), and sulphamethoxazole + trimethoprim (COT) was tested using the standard dilution technique and disc diffusion test...
  42. pmc The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassa
    Sabine Maerz
    Institut für Mikrobiologie und Genetik Abteilung Molekulare Mikrobiologie, Universitat Gottingen, D 37077 Gottingen, Germany
    Genetics 179:1313-25. 2008
    ..Here, we identify the cot-1 suppressor gul-4 as mak-2 and show that mutants of the gul-4/mak-2 mitogen-activated protein (MAP) kinase pathway ..
  43. doi Perforating globe injuries during operation Iraqi Freedom
    Marcus H Colyer
    Ophthalmology Service, Walter Reed Army Medical Center, Washington, DC, USA
    Ophthalmology 115:2087-93. 2008
    ..with perforating (through-and-through) injuries of the globe and the visual impact of these injuries on patients with combat ocular trauma (COT) seen at Walter Reed Army Medical Center (WRAMC) from March 2003 through October 2006.
  44. pmc BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes
    Valeriu B Cismasiu
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, U S A
    Biochem J 417:457-66. 2009
    ..of IkappaB kinase in the TCR/CD28 signalling pathway was affected by increased BCL11B expression, and found that Cot (cancer Osaka thyroid oncogene) kinase mRNA levels were elevated...
  45. pmc Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation
    Irene Soria-Castro
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid 28029
    J Biol Chem 285:33805-15. 2010
    Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo...
  46. ncbi Molecular differentiation of sex chromosomes probed by comparative genomic hybridization
    W Traut
    Institut fur Biologie, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Chromosoma 108:173-80. 1999
    ..simultaneously with FluorX-labelled DNA of females and Cy3-labelled DNA of males in the presence of an excess of Cot-1 DNA or unlabelled DNA of the homogametic sex...
  47. ncbi Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
    M Morillas
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    J Biol Chem 276:45001-8. 2001
    Carnitine palmitoyltransferase I (CPT I) and carnitine octanoyltransferase (COT) catalyze the conversion of long- and medium-chain acyl-CoA to acylcarnitines in the presence of carnitine...
  48. doi Head covering and the risk for SIDS: findings from the New Zealand and German SIDS case-control studies
    Edwin A Mitchell
    University of Auckland, Department of Paediatrics, Private Bag 92019, Auckland, New Zealand
    Pediatrics 121:e1478-83. 2008
    ..By using the data from 2 sudden infant death syndrome case-control studies, consistency of the findings could be assessed...
  49. pmc Characterization of X-chromosome inactivation status in human pluripotent stem cells
    Jennifer A Erwin
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2010
    This unit describes a method of performing fluorescent in situ hybridization (FISH) of XIST and Cot-1 RNA in human pluripotent stem cells (hPSC) to characterize the epigenetic status of X-chromosome inactivation (XCI)...
  50. pmc Maintenance treatment of gastroesophageal reflux disease: an evaluation of continuous and on-demand therapy with rabeprazole 20 mg
    D G Morgan
    Division of Gastroenterology, St Joseph s Healthcare, Hamilton, Canada
    Can J Gastroenterol 21:820-6. 2007
    To evaluate continuous therapy (COT) and on-demand therapy (ODT) with rabeprazole 20 mg for maintenance in uninvestigated gastroesophageal reflux disease (GERD).
  51. doi Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placenta
    J M Evoniuk
    Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA
    Placenta 29:422-8. 2008
    ..were collected at day 130, and placentomes were either separated into caruncular (CAR; maternal) or cotyledonary (COT; fetal) placenta and snap-frozen for PrPC mRNA expression or perfusion fixed for PrPC protein expression...
  52. ncbi Genes encoding spore coat polypeptides from Bacillus subtilis
    W Donovan
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    J Mol Biol 196:1-10. 1987
    ..To determine the location of the cot genes on the chromosome and to study their function genetically, we tagged each gene by insertion of a ..
  53. pmc Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family
    J A Zallen
    Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Department of Anatomy and Department of Biochemistry and Biophysics, The University of California, San Francisco, California 94143, USA
    Mol Biol Cell 11:3177-90. 2000
    ..kinase in the Ndr family that is related to the Orb6 (Schizosaccharomyces pombe), Warts/Lats (Drosophila), and COT-1 (Neurospora) kinases that function in cell shape regulation...
  54. ncbi Clothing fabric does not affect thermoregulation during exercise in moderate heat
    T P Gavin
    Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 33:2124-30. 2001
    ..We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics...
  55. pmc Integration of Cot analysis, DNA cloning, and high-throughput sequencing facilitates genome characterization and gene discovery
    Daniel G Peterson
    Center for Applied Genetic Technologies and Department of Crop and Soil Sciences, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 12:795-807. 2002
    b>Cot-based sequence discovery represents a powerful means by which both low-copy and repetitive sequences can be selectively and efficiently fractionated, cloned, and characterized...
  56. doi Syntheses and crystal structures of ruthenium and rhodium olefin complexes containing GaCp
    Thomas Cadenbach
    Anorganische Chemie II Organometallics and Materials, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Inorg Chem 48:5021-6. 2009
    ..of the olefin ligands to give [Ru(PPh(3))(2)(GaCp*)(3)] (2), whereas reaction of [Ru(eta(2),eta(2)-COD)(eta(6)-COT)] (COD = 1,5-cyclooctadiene, C(8)H(12), COT = 1,3,5-cyclooctatriene, C(8)H(10)) and GaCp* leads to [Ru(eta(2),eta(2)..
  57. ncbi Carnitine acyltransferases are not changed in Alzheimer disease
    I Maurer
    Department of Neurology, , Bonn, Germany
    Alzheimer Dis Assoc Disord 12:71-6. 1998
    We evaluated the activities of carnitine palmitoyltransferase (CPT), carnitine octanoyltransferase (COT), and carnitine acetyltransferase (CAT) in the frontal cortex, temporal cortex, parietal cortex, hippocampus, and cerebellum of ..
  58. ncbi Impact of a conjugate vaccine on community-wide carriage of nonsusceptible Streptococcus pneumoniae in Alaska
    Matthew R Moore
    Division of Applied Public Health Training, Epidemiology Program Office, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Infect Dis 190:2031-8. 2004
    ..Antimicrobial resistance among pneumococci has increased in recent years and complicates treatment. The introduction of heptavalent pneumococcal conjugate vaccine (PCV7) could reduce acquisition of antimicrobial-resistant pneumococci...
  59. ncbi Integrated in silico and biological validation of the blocking effect of Cot-1 DNA on Microarray-CGH
    Seung Hui Kang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Mol Med 19:901-8. 2007
    In array-CGH, various factors may act as variables influencing the result of experiments. Among them, Cot-1 DNA, which has been used as a repetitive sequence-blocking agent, may become an artifact-inducing factor in BAC array-CGH...
  60. ncbi Cryogenic oven-trapping gas chromatography for analysis of volatile organic compounds in body fluids
    K Watanabe-Suzuki
    Department of Legal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Anal Bioanal Chem 373:75-80. 2002
    Cryogenic oven-trapping (COT) with capillary GC has been successfully applied to analysis of chloroform, dichloromethane, trichloroethylene, diethyl ether, the components of solvent thinner (ethyl acetate, benzene, n-butanol, toluene, ..
  61. ncbi Does acupuncture improve the orthopedic management of chronic low back pain--a randomized, blinded, controlled trial with 3 months follow up
    Albrecht F Molsberger
    Orthopedic Surgery and Research, Kasernenstr 1b, 40213, Dusseldorf, Germany
    Pain 99:579-87. 2002
    ..5 years, 0.5-2 years, 2-5 years, >or=5 years. Analysis was by intention to treat. Group 1 (Verum+COT) received 12 treatments of verum acupuncture and conservative orthopedic treatment (COT)...
  62. ncbi A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine
    A J Ji
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 45:85-91. 1999
    ..In an attempt to assess THOC and cotinine (COT) concentrations during nicotine transdermal therapy, we developed a new quantitative gas chromatography-mass ..
  63. ncbi The efficacy of noncontact oxygen delivery methods
    Patrick Davies
    Luton and Dunstable NHS Trust, Luton, United Kingdom
    Pediatrics 110:964-7. 2002
    ..We wished to assess the concentration of oxygen delivered to the patient with various methods of "wafting" oxygen...
  64. ncbi Growth and survival of bacteria implicated in sudden infant death syndrome on cot mattress materials
    R O Jenkins
    School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK
    J Appl Microbiol 99:573-9. 2005
    To compare growth and survival of selected bacteria implicated in sudden infant death syndrome (SIDS) on cot mattress polyurethane (PU) inner-foams and on different types of cot mattress cover materials.
  65. ncbi Comparison of open dilatational tracheostomy with conventional pediatric tracheostomy in a growing animal model
    Chung Hwan Baek
    Department of Otorhinolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Laryngoscope 115:2193-8. 2005
    To compare the tracheal changes after applying a new open dilatational tracheostomy (ODT) technique with those from a conventional open tracheostomy (COT) with vertical cartilage incision in a growing animal model.
  66. pmc Randomised trial of infant sleep location on the postnatal ward
    H L Ball
    Parent Infant Sleep Laboratory and Medical Anthropology Research Group, Department of Anthropology, Durham University, Durham, UK
    Arch Dis Child 91:1005-10. 2006
    ..To determine whether postnatal mother-infant sleep proximity affects breastfeeding initiation and infant safety...
  67. ncbi Inflammatory signaling pathways regulating ApoE gene expression in macrophages
    Anca V Gafencu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    J Biol Chem 282:21776-85. 2007
    ....
  68. doi Traumatic brain injury associated with combat ocular trauma
    Eric D Weichel
    Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Ave, Washington, DC 20307, USA
    J Head Trauma Rehabil 24:41-50. 2009
    To determine the impact of traumatic brain injury (TBI) on visual outcomes in combat ocular trauma (COT) and determine the association between TBI severity and types of ocular injuries.
  69. pmc Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis
    Jennifer Jager
    Institut National de la Sante et de la Recherche Medicale INSERM, U895, Mediterranean Center of Molecular Medicine, Team 7 Molecular and Cellular Physiopathology of Obesity and Diabetes, Nice, France
    Diabetes 59:61-70. 2010
    ..This study aims at identifying proteins regulating ERK1/2 activity, specifically in response to inflammatory cytokines, to provide new insights into mechanisms leading to abnormal adipose tissue function...
  70. ncbi The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes
    W Jongmans
    MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands
    Mutat Res 364:91-102. 1996
    ..of V-E5, the presence of the mouse chromosome was determined by fluorescent in situ hybridization, using a mouse cot-1 probe...
  71. pmc A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck
    J S Dixon
    Department of Anatomy, Chinese University of Hong Kong, Hong Kong
    J Anat 190:125-34. 1997
    ..were obtained from 7 male infants and children ranging in age from 2 mo to 3 y who had died as a result of cot death or accidental trauma. On average 60% of the intramural neurons were non-TH-immunoreactive (-IR) (i.e...
  72. ncbi Sudden infant death, large intestinal volvulus, and a duplication cyst of the terminal ileum
    R W Byard
    State Forensic Science Centre, Department of Histopathology, Women s and Children s Hospital, Adelaide, Australia
    Am J Forensic Med Pathol 21:62-4. 2000
    A previously well 7-week-old boy was found unresponsive and cyanotic in his cot in the morning. Resuscitative attempts achieved only partial response with subsequent terminal cardiac arrest occurring later in the day...
  73. ncbi Measurement of extracellular fluid volume in the neonate using multiple frequency bio-impedance analysis
    B E Lingwood
    Perinatal Research Centre, University of Queensland, Royal Women s Hospital Brisbane, Australia
    Physiol Meas 21:251-62. 2000
    Bioelectrical impedance analysis may be useful for cot-side monitoring of fluid balance in the neonatal intensive care unit (NICU)...
  74. ncbi Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways
    W Zhang
    Department of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 274:872-9. 2000
    ..These findings suggested that DPK might be a novel candidate MAPKKK...
  75. pmc The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae
    S Bidlingmaier
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Mol Cell Biol 21:2449-62. 2001
    ..Cbk1p is most closely related to the Neurospora crassa Cot-1; Schizosaccharomyces pombe Orb6; Caenorhabditis elegans, Drosophila, and human Ndr; and Drosophila and mammalian ..
  76. ncbi Retrospective evaluation of patient compliance in continuous oxygen therapy
    Hande Demirel
    Department of Pulmonary Diseases, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey
    Respiration 70:149-53. 2003
    Prescription of continuous oxygen therapy (COT) for correct indications, adequate education of the patients, and a regular and sufficient oxygen intake are essential.
  77. ncbi PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells
    Jing Zhang
    Department of Pharmacology and Toxicology, Wright State University, School of Medicine, Dayton, OH 45435, USA
    Life Sci 77:953-65. 2005
    K-Cl cotransport (K-Cl COT, KCC) is an electroneutrally coupled movement of K and Cl present in most cells...
  78. ncbi Signal transduction mechanisms of K+-Cl- cotransport regulation and relationship to disease
    N C Adragna
    Cell Biophysics Group, Wright State University School of Medicine, Dayton, OH 45435, USA
    Acta Physiol (Oxf) 187:125-39. 2006
    The K+-Cl- cotransport (COT) regulatory pathways recently uncovered in our laboratory and their implication in disease state are reviewed...
  79. ncbi Strategies to improve photostabilities in ultrasensitive fluorescence spectroscopy
    Jerker Widengren
    Experimental Biomolecular Physics, Department of Applied Physics, AlbaNova University Center, Royal Institute of Technology, SE 10691 Stockholm, Sweden
    J Phys Chem A 111:429-40. 2007
    ..gallate, nPG, ascorbic acid, AA) and triplet state quenchers (mercaptoethylamine, MEA, cyclo-octatetraene, COT), were investigated, and the relevant rate parameters involved were determined for the dye Rhodamine 6G...
  80. ncbi Application of a cell-once-through perfusion strategy for production of recombinant antibody from rCHO cells in a Centritech Lab II centrifuge system
    Byoung Jin Kim
    Department of Bioscience and Biotechnology, Sejong University, 98 Gunja Dong, Gwangjin gu, Seoul 143 747, Korea
    Biotechnol Prog 23:1186-97. 2007
    Based upon the results of scale-down intermittent perfusion processes, a cell-once-through (COT) perfusion concept was applied to a dual bioreactor system coupled to a Centritech Lab II centrifuge for culture of recombinant Chinese ..
  81. ncbi Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway
    Dmitriy Ovcharenko
    Asuragen Inc, Austin, Texas, USA
    Cancer Res 67:10782-8. 2007
    ..In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses...
  82. ncbi Marine bacteria comprise a possible indicator of drowning in seawater
    Eiji Kakizaki
    Section of Legal Medicine, Department of Social Medicine, Faculty of Medicine Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Forensic Sci Int 176:236-47. 2008
    ..Blue colonies stained using the cytochrome oxidase test (COT), were detected in blood mixed with both sea and river water...
  83. doi Determination of brominated flame retardants in food by LC-MS/MS: diastereoisomer-specific hexabromocyclododecane and tetrabromobisphenol A
    Malcolm Driffield
    CSL, Food Science Group, Sand Hutton, York YO41 1LZ, UK
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:895-903. 2008
    ..The UK Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) concluded that the concentrations of HBCD and TBBPA detected in the TDS study did not raise toxicological concerns ..
  84. doi Cot-side electro-encephalography and interstitial glucose monitoring during insulin-induced hypoglycaemia in newborn lambs
    Deborah L Harris
    Newborn Intensive Care Unit, Waikato District Health Board, Hamilton, New Zealand
    Neonatology 95:271-8. 2009
    ..The optimal approach to detection and management of neonatal hypoglycaemia remains unclear...
  85. doi Visceral leishmaniasis is preventable in a highly endemic village in West Bengal, India
    Subhasish Saha
    Field Epidemiology Training Programme, National Institute of Epidemiology, Indian Council of Medical Research, Ayapakkam, Chennai, TN, India
    Trans R Soc Trop Med Hyg 103:737-42. 2009
    ..5) and livestock ownership (RR 2.4). Sleeping dressed (RR 0.4), or under a bed net (RR 0.5) or in a cot (RR 0.6) were associated with a lower risk...
  86. doi Cancer Osaka thyroid (Cot) phosphorylates Polo-like kinase (PLK1) at Ser137 but not at Thr210
    Binhui Wu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Biol Chem 390:1271-7. 2009
    Cancer Osaka thyroid (Cot) is a proto-oncogenic kinase which belongs to the MAP3K family. A peptide-based substrate screening assay revealed that Cot has the ability to phosphorylate Polo-like kinase 1 (Plk1) at Ser137...
  87. doi Nasal turbinate enlargement due to cartilage and bone proliferation: a normal developmental finding in young ferrets
    Kathleen A Funk
    Experimental Pathology Laboratories, Inc Sterling, Virginia, USA
    Toxicol Pathol 38:1064-9. 2010
    ..led to this detailed microscopic evaluation of turbinate enlargement (cartilaginous and osseous thickening, or COT) in control animals dosed intranasally with saline...
  88. doi Scaling of swim speed in breath-hold divers
    Yuuki Y Watanabe
    National Institute of Polar Research, Tachikawa, Tokyo 190 8518, Japan
    J Anim Ecol 80:57-68. 2011
    ..to descend and ascend at the speed that minimizes energy expenditure per distance travelled (the cost of transport (COT)) to maximize foraging duration at depth...
  89. doi Gold(III) N-heterocyclic carbene complexes mediated synthesis of β-enaminones from 1,3-dicarbonyl compounds and aliphatic amines
    Manoja K Samantaray
    Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076
    Inorg Chem 50:1840-8. 2011
    ..R(1) = i-Pr, R(2) = CH(2)Ph (1c); R(1) = mesityl, R(2) = CH(2)Ph (2c); R(1) = i-Pr, R(2) = CH(2)COt-Bu (3c), and R(1) = t-Bu, R(2) = CH(2)COt-Bu (4c)] act as effective precatalysts in the synthesis of β-enaminones ..
  90. doi Knockdown of osteopontin chemosensitizes MDA-MB-231 cells to cyclophosphamide by enhancing apoptosis through activating p38 MAPK pathway
    Hui Pang
    Department of Oncology Medicine, the Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
    Cancer Biother Radiopharm 26:165-73. 2011
    ..Therefore, this study concludes that OPN knockdown chemosensitizes MDA-MB-231 cells to CTX by enhancing apoptosis through activating p38 MAPK pathway...
  91. pmc Simultaneous quantification of nicotine and metabolites in rat brain by liquid chromatography-tandem mass spectrometry
    Paula L Vieira-Brock
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 879:3465-74. 2011
    ..mass spectrometry (LC-MS/MS) method for simultaneous quantification of nicotine (NIC), cotinine (COT), nornicotine (NNIC), norcotinine (NCOT), nicotine-N-β-D-glucuronide (NIC GLUC), cotinine-N-β-D-glucuronide (COT ..
  92. pmc Evaluation of the minimum energy hypothesis and other potential optimality criteria for human running
    Ross H Miller
    Department of Kinesiology, University of Massachusetts, Amherst, MA, USA
    Proc Biol Sci 279:1498-505. 2012
    ..running is that gait mechanics and muscular activity are optimized in order to minimize the cost of transport (CoT)...
  93. doi Simultaneous quantitation of urinary cotinine and acrylonitrile-derived mercapturic acids with ultraperformance liquid chromatography-tandem mass spectrometry
    Chia Fang Wu
    Department of Public Health and Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
    Anal Bioanal Chem 402:2113-20. 2012
    ..major AN urinary metabolites (CEMA, HEMA, and CHEMA) to assess AN exposure, as well as analyze urinary cotinine (COT) as an indicator for tobacco smoke exposure. The limits of quantitation were 0.1, 0.1, 1.0, and 0...
  94. doi An experimental estimate of the relative aromaticity of the cyclooctatetraene dianion by fusion to dimethyldihydropyrene
    Reginald H Mitchell
    Department of Chemistry, University of Victoria, P O Box 3065, Victoria, BC V8V 3V6, Canada
    Chem Commun (Camb) 48:8144-6. 2012
    The synthesis of the cyclooctatetraene dianion (COT(2-)) fused at the [e]-position of trans-10b,10c-dimethyl-10b,10c-dihydropyrene (DHP) is described, and by comparison of (1)H NMR properties and NICSAv to the analogous benzene fused DHP,..
  95. doi Designing in vitro assays for drug discovery: a study with the human MAP3 kinase COT
    Yong Jia
    Department of Molecular Pharmacology, Abbott Laboratories, 100 Research Drive, Worcester, MA 01605, USA 1 508 849 2971 1 508 754 7784
    Expert Opin Drug Discov 2:909-15. 2007
    ..protein? When using a protein substrate, should it be physiologically relevant? In this perspective article, these questions will be addressed using examples from a study with the human mitogen-activated protein kinase kinase kinase COT.
  96. doi Factors affecting metabolic cost of transport during a multi-stage running race
    Stefano Lazzer
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Exp Biol 217:787-95. 2014
    The aim of this study was to investigate: (1) the role of , the fraction of (F) and the metabolic cost of transport (CoT) in determining performance during an ultra-endurance competition and (2) the effects of the race on several ..
  97. pmc Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis
    Manolis Roulis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari 16672, Greece
    Proc Natl Acad Sci U S A 111:E4658-67. 2014
    Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory bowel diseases (IBDs)...
  98. doi Bottlenose dolphins modify behavior to reduce metabolic effect of tag attachment
    Julie M van der Hoop
    Massachusetts Institute of Technology Woods Hole Oceanographic Institution Joint Program in Oceanography Applied Ocean Science and Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Woods Hole Oceanographic Institution, 266 Woods Hole Road, Woods Hole, MA 02543, USA
    J Exp Biol 217:4229-36. 2014
    ..mass-specific oxygen consumption, physical activity ratios (exercise /resting ), total or net cost of transport (COT; J m(-1) kg(-1)) or locomotor costs during swimming or two-minute recovery phases...
  99. pmc Suppression of mitochondrial biogenesis through toll-like receptor 4-dependent mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling in endotoxin-induced acute kidney injury
    Joshua A Smith
    Department of Drug Discovery and Biomedical Sciences J A S, L J S, J B C, R G S and Division of Transplant Surgery, Department of Surgery K D C, Medical University of South Carolina, Charleston, South Carolina and Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina R G S
    J Pharmacol Exp Ther 352:346-57. 2015
    ..Immunoblot analysis revealed activation of tumor progression locus 2/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (TPL-2/MEK/ERK) signaling ..
  100. doi Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum
    Ying Liu
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, People s Republic of China
    Mol Endocrinol 29:703-15. 2015
    ..Our results here first show that all of the CL cells express MAPK 8 (MAP3K8), and the MAP3K8 level is much higher at the midstage than at the early and late stages during CL development...
  101. pmc Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis
    Gui Qi Zhu
    Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Oncotarget 6:24533-49. 2015
    Most comprehensive treatments for PBC include UDCA, combination of methotrexate (MTX), corticosteroids (COT), colchicine (COC) or bezafibrate (BEF), cyclosporin A (CYP), D-penicillamine (DPM), methotrexate (MTX), or azathioprine (AZP)...

Research Grants55

  1. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
    ..exercise training at the limb ischemic threshold (SET) will produce a greater clinical benefit (increases in COT and PWT) than placebo plus supervised exercise at the limb ischemic threshold (PET)...
  2. Physician Monitoring System for Nicotine and Metabolites
    BADAWI M DWEIK; Fiscal Year: 2012
    ..electrochemical monitor for simultaneous on-site measurement of nicotine and its major metabolites [cotinine (COT) and 3-hydroxycotinine (3HC)] from a single urine sample in near real time to assess personal exposure...
  3. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
    ..We propose to examine the mechanism by which tumor progression locus 2 (Tpl2), a serine/threonine kinase in the MAPK signal transduction cascade, affects skin cancer ..
  4. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
    ..Studies outlined in this grant application will test hypotheses concerning how the actions of Tumor Progression Locus 2 (TPL2), an 'upstream'mediator of inflammatory signaling, promote obesity-associated ..
  5. Jason David Allen; Fiscal Year: 2014
    ..We have also shown an 18% and 17% increase in COT and PWT respectively in PAD-only, following a single dose ingestion of a high-nitrate containing beverage which ..
  6. Tpl2 in Intestinal Tumorigenesis
    Philip N Tsichlis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The proto-oncogene encoding the Tpl2 kinase is activated by provirus integration in retrovirus-induced rodent lymphomas and mammary adenocarcinomas...
  7. TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE
    ANIRUDDHA PUNTAMBEKAR; Fiscal Year: 2010
    ..ever, point-if-care test (POCT) to determine the ratio of nicotine metabolites;3-hydroxycotinine/cotinine (3HC/COT)...
  8. Wendy T Watford; Fiscal Year: 2016
    ..We recently demonstrated that Map3k8 transduces TCR signals in naive T cells and helps to specify a Th1 transcriptional program...
  9. MAP3K8-mediated regulation of adaptive immune responses and autoimmunity
    Wendy T Watford; Fiscal Year: 2012
    ..We recently demonstrated that Map3k8 transduces TCR signals in naive T cells and helps to specify a Th1 transcriptional program...
  10. Musculoskeletal Diagnoses Cohort: Examining Pain and Pain Care in the VA
    Robert D Kerns; Fiscal Year: 2013
    ..reports and comorbid depression;and adverse events, and their predictors, associated with chronic opioid therapy (COT);and 3) Estimate the costs of MSD care, by patient and facility characteristics, and by clinical characteristics (e...
  11. TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE
    ANIRUDDHA PUNTAMBEKAR; Fiscal Year: 2011
    ..Nicotine is metabolized to COT and then to 3HC...
  12. COPE-P: Shared Decision-Making Aid for Patients Regarding Chronic Opioid Therapy
    Susan A Stoner; Fiscal Year: 2010
    ..plans to issue a Risk Evaluation and Mitigation Strategy to manage risks associated with chronic opioid therapy (COT),underscoring the urgent need for new strategies to assure quality pain care while limiting opioid abuse and ..
  13. Tp12-dependent IFN-g production: contribution to host defense and autoimmunity
    Wendy T Watford; Fiscal Year: 2011
    ..attempt to gain insight into the molecular basis of IL-12's action we identified the serinethreonine kinase, Tpl2, as an IL-12-inducible gene...
  14. Deepika Mohan; Fiscal Year: 2014
    ..The American College of Surgeons - Committee on Trauma (ACS-COT) has attempted to improve regionalization by targeting known determinants of behavior: knowledge, attitudes, and ..
  15. Shao Cong Sun; Fiscal Year: 2016
    ..Over the past few years, we have made seminal findings demonstrating a pivotal TLR signaling axis: the IKK/Tpl2 axis...
  16. Martine Extermann; Fiscal Year: 2016
    ..model could then be tested as a clinical decision aid, as a tool for comparative effectiveness, quality of life, and cot-effectiveness studies and might contribute in the longer term to improved outcomes for this underserved population.
  17. Mark D Sullivan; Fiscal Year: 2014
    ..These trends run parallel to increases in use of chronic opioid therapy (COT) for chronic non-cancer pain (CNCP), now estimated at 10 million recipients or 3% of the US population...
  18. Ramin Samadani; Fiscal Year: 2014
    ..can overcome resistance induced by mutations that occur in MEK1 as well as overexpression of mitogen activated protein kinase kinase kinase 8 (MAP3K8 or COT)...
  19. SHORT-CHAIN ACYLCARNITINES--FUNCTION AND ENZYMOLOGY
    LORAN BIEBER; Fiscal Year: 1993
    ..Similarly, the evidence for a role for CAt, as well as carnitine octanoyltransferase, COT, in the peroxisomal chain-shortening of long- chain fatty acids is very strong [Ann...
  20. GENETIC DIFFERENTIATION IN AEDES ALBOPICIUS SUBGROUP
    KARAMJIT RAI; Fiscal Year: 1991
    ..albopictus and the four other subgroup species will be analysed through CoT curve analysis and cloning of satellite and rapidly reassociating DNA respectively...
  21. Portable nanofluidic aptamer-SERS instrument for measurement of chemical exposure
    George W Jackson; Fiscal Year: 2012
    ..SERS) nanochannel cartridge that was invented at Texas A&M University by professors Jun Kameoka and Gerard Cot[unreadable]...
  22. International Conference on Tobacco Induced Diseases
    Denis Kinane; Fiscal Year: 2004
    ..Periodontitis;12. Heart disease;13. Pregnancy complications; 14. Sudden Infant Death Syndrome (Cot Death); 15. Birth Defects Treatment: 15. Molecular biology of cancer/xenobiotics gene polymorphisms; 16...
  23. Regulation of the Tp12 Kinase
    Philip Tsichlis; Fiscal Year: 2009
    ..Overexpression of Tpl2 in a variety of cell types activates ERK, JNK, p38 MAPK, and the transcription factors NF-AT and NF-KB...
  24. ROLE OF TPL-2, CYCLIN D1 AND TOUVLO IN BREAST CANCER
    Christos Patriotis; Fiscal Year: 2002
    ..The obtained result will enhance our understanding of the growth regulation of normal and neoplastic mammary epithelia and may identify molecular markers for diagnosis and therapeutic intervention. ..
  25. CELLULAR REGULATION OF PHOSPATE TRANSPORT IN KIDNEY
    Thomas Dousa; Fiscal Year: 1993
    ..stimuli regulate Pi transport across BBM by changing rate or mode of biogenesis of the Na-Pi cotransporter (Na-Pi-COT) of BBM, whereas short-term "rapid" stimuli act by the changing balance between Na-Pi-COT within BBM and Na-P-COT ..
  26. ROLE OF TVI 1 IN APOPTOSIS
    Philip Tsichlis; Fiscal Year: 2004
    ..This application addresses the role of Tvl-1 in the assembly and function of such complexes. ..
  27. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2003
    ..Interestingly, one of the putative IKK upstream kinases, Cot, physically interacts with Tax...
  28. Offspring of Twins: G,E and GxE Risks for Alcoholism
    Theodore Jacob; Fiscal Year: 2009
    ..Our approach is distinguished by two significant design characteristics: (1) use of the powerful children of twins (COT) design involving twins in the parent generation who are concordant or discordant for alcohol dependence (and ..
  29. HIV-1 Diversity in Vaccine Evaluation and Design
    Uma Malhotra; Fiscal Year: 2006
    ..subtype B (US), and subtype C (India) infections, using two central sequence [Consensus (Con) and Center of Tree (COT)] based peptide sets...
  30. GxE in Early Childhood: Twin Mothers
    Andrew Heath; Fiscal Year: 2009
    ..This R01 makes use of a children-of-twins (COT) paradigm, building upon a prospective study of female like-sex twin pairs who were first assessed in adolescence (..
  31. JAMES W MELVIN; Fiscal Year: 2014
    ..Budge Jutificthioenf utndswillbeusedto suprt rining ourech vene rntalf etrvs el ndperdiem upplie,publiction cot, regitraionfee,andspekerfTehee...
  32. Genetic and Molecular Signaling in Heart Failure
    Evangelia Kranias; Fiscal Year: 2009
    ..Related Project 4 (Molkentin) will define the interactions of PPI1 with protein kinase Cot, itself transcriptionally upregulated in heart failure, and delineate their combined effects on myocardial ..
  33. DNA REARRANGEMENTS IN MOMULV INDUCED THYMOMAS
    Philip Tsichlis; Fiscal Year: 2000
    ..The long term objective of this project is to use the Tpl-2 protoncogene as a probe to explore the biology of the immune system and the pathobiology of neoplasia with emphasis on tumor progression and metastasis. ..
  34. Integrated Care for Depression and Chronic Back Pain
    Michael Von Korff; Fiscal Year: 2006
    ..abstract_text> ..
  35. Third Symposium Cell Volume & Signalling Regulation
    PETER LAUF; Fiscal Year: 2003
    ..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
  36. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ..These sheep red blood cell (SRBC) proteins are functionally associated with the Na/K pump and K-CI cotransporter (COT)...
  37. Depression-Diabetes Care Disparities, Adverse Outcomes
    Michael Von Korff; Fiscal Year: 2008
    ..Aim 3: Set priorities for integrated services - We will assess criteria relevant to priorities for integrated management of diabetes, depression and associated behavioral risk factors. [unreadable] [unreadable]..
  38. Social Role Disability and Mental-Physical Co-Morbidity
    Michael Von Korff; Fiscal Year: 2007
    ..abstract_text> ..
  39. Long-term Opioid Management of Chronic Pain: Trends and Risks
    Michael Von Korff; Fiscal Year: 2009
    ..We will extend these analyses by studying the effects of long-term opioid therapy on other adverse events including: all-cause and opioid-related hospitalization;opioid overdose;and onset of recognized mood disorder. ..
  40. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    ....
  41. EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS
    Andrew Gardner; Fiscal Year: 2004
    ....
  42. Risks for Opioid Use and Abuse in Contrasting Chronic Pain Populations
    Mark Sullivan; Fiscal Year: 2009
    ....
  43. Determinants of Behavior Problems after Divorce
    BRIAN D ONOFRIO; Fiscal Year: 2003
    ..abstract_text> ..
  44. Impact of Smoking Cessation on Sleep
    Gary Swan; Fiscal Year: 2008
    ..The results of this project will be particularly important for the development of targeted treatment approaches designed to ameliorate sleep disruption as part of an overall smoking cessation strategy. ..
  45. Comprehensive Support for Alzheimer's Disease Caregivers
    JOSEPH GAUGLER; Fiscal Year: 2008
    ..The proposed evaluation will provide detailed information on the potential of the ECS to serve as a model intervention for various family caregivers of Alzheimer?s patients in diverse geographic contexts. [unreadable]..
  46. CVD RISK FACTORS AND BRAIN MORPHOLOGY IN NHLBI TWINS
    Gary Swan; Fiscal Year: 2001
    ....
  47. Family Involvement /Resident Psychosocial Status in LTC
    JOSEPH GAUGLER; Fiscal Year: 2002
    ..abstract_text> ..
  48. Caregiver Outcomes Post NH Placement of a Family Member
    JOSEPH GAUGLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. PHARMACOKINETICS OF NICOTINE IN TWINS
    Gary Swan; Fiscal Year: 2002
    ..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
  50. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2009
    ....
  51. Designing musculoskeletal disorder interventions for imaging technologists
    Carolyn M Sommerich; Fiscal Year: 2010
    ....
  52. Macaque Model of Carpal Tunnel Syndrome: Effects of Force and Posture Exposures
    Carolyn M Sommerich; Fiscal Year: 2010
    ..Now we need to differentiate amongst exposures, in terms of extent of nerve impairment, so that, in the long term, the risk for development or recurrence of work- related CTS can be reduced. ..
  53. Familial Transmission of Youth Suicidal Behavior
    Anne Glowinski; Fiscal Year: 2006
    ....
  54. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2007
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..