MAOB

Summary

Gene Symbol: MAOB
Description: monoamine oxidase B
Alias: amine oxidase [flavin-containing] B, MAO, brain, MAO, platelet, MAO-B, adrenalin oxidase, monoamine oxidase type B, tyramine oxidase
Species: human

Top Publications

  1. ncbi Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Am J Med Genet B Neuropsychiatr Genet 120:58-62. 2003
  2. ncbi Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population
    Monika Białecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Eur Neurol 53:68-73. 2005
  3. ncbi Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease
    John L Goudreau
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:1305-11. 2002
  4. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
  5. ncbi Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia
    R J Wyatt
    Science 179:916-8. 1973
  6. ncbi The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
    R M Wu
    Department of Neurology, College of Medicine, National Taiwan University and National Taiwan University Hospital
    Neurology 56:375-82. 2001
  7. ncbi MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 58:1381-7. 2002
  8. ncbi Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
  9. ncbi Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation
    Wai K Wong
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:36227-35. 2003
  10. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004

Detail Information

Publications191 found, 100 shown here

  1. ncbi Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Am J Med Genet B Neuropsychiatr Genet 120:58-62. 2003
    Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the MAO B gene may modify the relationship between smoking and Parkinson's Disease (PD)...
  2. ncbi Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population
    Monika Białecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Eur Neurol 53:68-73. 2005
    ..It has been suggested that polymorphisms in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might increase the risk of PD...
  3. ncbi Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease
    John L Goudreau
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:1305-11. 2002
    ..These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings...
  4. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
    Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3...
  5. ncbi Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia
    R J Wyatt
    Science 179:916-8. 1973
    ..These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia...
  6. ncbi The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
    R M Wu
    Department of Neurology, College of Medicine, National Taiwan University and National Taiwan University Hospital
    Neurology 56:375-82. 2001
    Reports suggest that catechol-O-methyltransferase (COMT(L/L)) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD...
  7. ncbi MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 58:1381-7. 2002
    A polymorphism (G to A transition) in intron 13 of the mitochondrial enzyme monoamine oxidase B (MAOB) gene may modify, alone or by interacting with the catechol-O-methyltransferase (COMT(LL)) genotype (low enzymatic activity), the risk ..
  8. ncbi Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
    ..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD...
  9. ncbi Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation
    Wai K Wong
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:36227-35. 2003
    ..Here we show that MAO B, but not MAO A, gene expression was induced during Caco-2 cell differentiation; thus this cell line was used as a ..
  10. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia...
  11. ncbi Monoamine oxidases A and B gene polymorphisms in migraine patients
    Vedrana Filic
    Laboratory of Neurochemistry and Molecular Neurobiology, Dept of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, Zagreb HR 10000, Croatia
    J Neurol Sci 228:149-53. 2005
    ..The suggestive association of the variant in MAO-A gene with migraine is considered worthy of independent replication. On the other hand, further studies on MAO-B polymorphism in migraine do not seem promising...
  12. ncbi The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
    Nela Pivac
    Division of Molecular Medicine, Rudjer Boskovic Institute, PO Box 180, HR 10002 Zagreb, Croatia
    Life Sci 79:45-9. 2006
    ....
  13. doi Polymorphism in environment responsive genes and association with Parkinson disease
    Madhu Singh
    Developmental Toxicology Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Mol Cell Biochem 312:131-8. 2008
    ..on their corresponding loci revealed that four combinations of GSTT1 null and MnSOD(-9Val) or GST null and MAOB-G or CYP2E1*5B and MAO-B-AG or CYP2E1*5B and DRD2 (Taq1A-het) genotypes in the patients exhibited severalfold ..
  14. doi Recent adaptive selection at MAOB and ancestral susceptibility to schizophrenia
    Noa Carrera
    Fundación Pública Galega de Medicina Xenómica FPGMX, University of Santiago Hospital Complex, Santiago de Compostela, Spain
    Am J Med Genet B Neuropsychiatr Genet 150:369-74. 2009
    ..In order to test this hypothesis in schizophrenia, we focused on the monoamine oxidase B gene (MAOB)...
  15. doi Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population
    Patricia Gasso
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, IDIBAPS, Barcelona, Spain
    Neuropsychobiology 58:65-70. 2008
    ..Monoamine oxidase B (MAO-B) enzyme is involved in the oxidative metabolism of dopamine. We studied whether the A644G polymorphism in intron 13 of the MAO-B gene is a risk factor for schizophrenia...
  16. pmc Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    J Neural Transm (Vienna) 116:1323-34. 2009
    Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect...
  17. doi A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions
    Giuseppe De Palma
    Department of Experimental and Applied Medicine, University of Brescia, Italy
    Mov Disord 25:912-9. 2010
    ..CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA...
  18. doi Smoking, genes encoding dopamine pathway and risk for Parkinson's disease
    Zhuqin Gu
    Department of Neurology and Neurobiology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Xuanwu Hospital Capital Medical University, 100053 Beijing, China
    Neurosci Lett 482:31-4. 2010
    ..Our data support a reduction of PD risk associated with smoking in a Chinese population. These variants of genes associated with DA uptake and metabolism do not affect the inverse association between smoking and PD...
  19. ncbi Inhibition of monoamine oxidase B in the brains of smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 379:733-6. 1996
    ..Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers...
  20. ncbi Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease
    David R Lynch
    Department of Neurology, University of Pennsylvania and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 18:804-12. 2003
    ..These results demonstrate that these specific genetic variations do not alter the fidelity of (99)Tc-TRODAT-1 as a measure of dopaminergic function in asymptomatic volunteer individuals or patients with PD...
  21. ncbi A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease
    H Checkoway
    Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
    Neurology 50:1458-61. 1998
    ..These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism...
  22. ncbi Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women
    F Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Mol Psychiatry 13:334-47. 2008
    ..experienced CSA; we also tested whether haplotypes covering the region where both MAOA and monoamine oxidase B (MAOB) genes are located predict risk of alcoholism and ASPD better than the MAOA-LPR locus alone...
  23. pmc Structure of the human gene for monoamine oxidase type A
    Z Y Chen
    Department of Biochemistry, University of Oxford, UK
    Nucleic Acids Res 19:4537-41. 1991
    ..The exon structure of human MAOA is similar to that described by others for human MAOB. Exon 12 (bearing the codon for cysteine, which carries the covalently bound FAD cofactor) and exon 13 are highly ..
  24. ncbi Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice
    Hsiang Shu Yin
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Synapse 60:573-84. 2006
    ..Moreover, MAOB is region-dependently involved in responses of the brain to Amph and baclofen, supporting interactions between GABA ..
  25. ncbi Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 17:867-72. 2007
    The genes of catalytic enzymes of dopamine, including monoamine oxidase (MAOA and MAOB) and catechol-O-methyltransferase (COMT), have been major candidates for genes that affect smoking behavior...
  26. ncbi [Deep brain stimulation for Parkinson's disease and dystonia]
    Fusako Yokochi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Brain Nerve 61:473-83. 2009
    ..Presently, many types of dopamine agonists, monoamine oxidase B (MAOB) inhibitors, catechol-O-methyltransferase (COMT) inhibitor or other antiparkinsonian drugs are being developed...
  27. ncbi The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats
    Thomas E Wooters
    Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Behav Pharmacol 18:601-8. 2007
    ..examined the effects of three MAOIs (phenelzine, clorgyline and pargyline) with varying selectivity for MAOA and MAOB in the nicotine drug discrimination procedure in rats...
  28. ncbi Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives
    Tania Vitalis
    Department of Anatomy and Developmental Biology, University College London, WC1E6BT London, United Kingdom
    J Comp Neurol 464:392-403. 2003
    ..We generated a highly specific antibody to MAOB; immunoreactivity is entirely abolished in brain extracts or brain sections of mice lacking MAOB...
  29. ncbi The monoamine regulon including syntheses of arylsulfatase and monoamine oxidase in bacteria
    Y Murooka
    Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan
    Biosci Biotechnol Biochem 60:935-41. 1996
    ..monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA...
  30. ncbi Rapid enzymatic analysis of plasma for tyrosine
    H Shimizu
    Diagnostic Research Laboratory, Ono Pharmaceutical Co, Ltd, Osaka, Japan
    Clin Chem 36:32-5. 1990
    ..1.1.25) and the tyramine produced is oxidized to p-hydroxybenzyl aldehyde and hydrogen peroxide by action of tyramine oxidase (EC 1.4.3.9)...
  31. ncbi Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22
    M A Pook
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, London, UK
    Hum Mol Genet 2:2129-34. 1993
    ..22. Combined multilocus linkage analysis and deletion mapping studies defined the locus order Xpter-MAOB-(ARAFI, DXS426)-SYP-TFE3-(DXS255, DENT'S)-DXS988-Xcen, thereby mapping the microdeletion associated with Dent's ..
  32. ncbi The Wiskott-Aldrich syndrome gene as a candidate gene for atopic dermatitis
    M Bradley
    Department of Dermatology and Venereology, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Acta Derm Venereol 81:340-2. 2001
    ..We found that the marker MAOB gave positive linkage with a maximum lod score of 1.68 (p<0.05) to the severity score of atopic dermatitis...
  33. doi Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..of six genes (calsequestrin, NNAT, neurogranin, secreted protein acidic and rich in cysteine (SPARC), EGR2, and MAOB) were confirmed by RT-PCR in 25 PCs...
  34. doi Comparative analysis of monoamine oxidase intronic polymorphisms in primates
    Kyung Won Hong
    The United Graduate School of Agricultural Science, Gifu University, Gifu 501 1193, Japan
    Gene 418:9-14. 2008
    ..Two isozymic genes, MAOA and MAOB, have been identified, both of which are located on the X chromosome...
  35. ncbi Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse
    Tania Vitalis
    Department of Biomedical Sciences, Edinburgh EH8 9XD, Scotland, United Kingdom
    J Comp Neurol 442:331-47. 2002
    Monoamine oxidases A (MAOA) and B (MAOB) are key players in the inactivation pathway of biogenic amines...
  36. pmc maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli
    M Yamashita
    Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan
    J Bacteriol 178:2941-7. 1996
    ..The nucleotide sequence of this fragment was determined, and a single open reading frame (maoB) consisting of 903 bp was found...
  37. pmc Interaction of neurotrophin signaling with Bcl-2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growth
    John P Renton
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa
    J Neurosci Res 88:2239-51. 2010
    ..Here we assessed the consequences of Bcl-2 targeted to either the mitochondria (GFP-Bcl-2-Maob) or the endoplasmic reticulum (ER, GFP-Bcl-2-Cb5) on cultured SGN survival and neurite growth...
  38. doi Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Kakamigahara, Gifu 504 0838, Japan
    Expert Rev Neurother 9:1233-50. 2009
    ..Inhibitors of type B monoamine oxidase (MAOB-Is), rasagiline and (-)deprenyl, are the most promising candidate neuroprotective drugs...
  39. doi Histamine oxidation in mouse adipose tissue is controlled by the AOC3 gene-encoded amine oxidase
    Z Iffiú-Soltész
    INSERM U858, IFR 150, I2MR, Universite Toulouse III Paul Sabatier, CHU Rangueil, Toulouse, France
    Inflamm Res 59:S227-9. 2010
    ..However, direct histamine effects on AT remain poorly documented: it has been observed that histamine stimulates lipolysis in rodent adipocytes when its oxidation by amine oxidases (AOs) is blocked by inhibitors such as semicarbazide...
  40. pmc A gene for X-linked optic atrophy is closely linked to the Xp11.4-Xp11.2 region of the X chromosome
    J J Assink
    Department of Ophthalmogenetics, The Netherlands Ophthalmic Research Institute, Amsterdam
    Am J Hum Genet 61:934-9. 1997
    ..Close linkage without recombination was found at the MAOB locus (maximum LOD score [Zmax] 4.19). The Zmax - 1 support interval was found at a recombination fraction of ...
  41. ncbi Is there a "non-MAO" macromolecular target for L-deprenyl?: Studies on MAOB mutant mice
    J Ekblom
    Department of Neuroscience, Uppsala University, Sweden
    Life Sci 63:PL181-6. 1998
    ..In the present study we have investigated if brain tissue from MAOB knockout mice contain such "non-MAO" binding sites for radiolabelled deprenyl...
  42. ncbi Immunocytochemical localization of monoamine oxidase type B in enterochromaffin-like cells of rat oxyntic mucosa
    H Okauchi
    Department of Surgery, Shiga University of Medical Science, Seta, Tsukinowa cho, Otsu, 520 2192, Shiga, Japan
    Histochem Cell Biol 121:181-8. 2004
    We used immunohistochemistry to identify the localization of monoamine oxidase type B (MAOB) in the rat oxyntic mucosa. At light microscopic levels, MAOB-immunopositive cells were mostly located in the basal half of the oxyntic mucosa...
  43. ncbi X-linked recessive primary retinal dysplasia is linked to the Norrie disease locus
    Y Ravia
    Genetic Institute, Sheba Medical Center, Tel Hashomer, Israel
    Hum Mol Genet 2:1295-7. 1993
    ..We have performed linkage analysis of the family using the L1.28, p58-1 and m27 beta probes, and DXS426 and MAOB associated microsatellites...
  44. ncbi Further linkage evidence for localization of mutational sites for nonsyndromic types of X-linked mental retardation at the pericentromeric region
    R Robledo
    Istituto di Genetica Molecolare del CNR, Alghero, Italy
    Am J Med Genet 64:107-12. 1996
    ..21 at zero recombination value. Recombination with the disease was found with markers MAOB and DXS454 located at Xp11.4-p11.3 and Xq21.1-q22, respectively; accordingly, markers distal to Xp11...
  45. ncbi Sixth World Congress of Psychiatric Genetics X Chromosome Workshop
    A D Paterson
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Am J Med Genet 88:279-86. 1999
    ..camh.net/ research/x-chromosome/. No linkage or transmission disequilibrium of polymorphisms of MAOA and MAOB in attention deficit hyperactivity disorder was seen...
  46. ncbi Nonsyndromic X-linked mental retardation: mapping of MRX58 to the pericentromeric region
    E Holinski-Feder
    Abteilung Medizinische Genetik der Kinderpoliklinik, Munchen, Germany
    Am J Med Genet 86:102-6. 1999
    ..09 (straight theta = 0) for the 7 cosegregating markers DXS1243, CybB, MAOB, DXS988, ALAS2, DXS991, and AR. MRX58 thus mapped within a 50-cM interval between Xp11.3 and Xq13...
  47. ncbi Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse
    K Ikemoto
    Department of Anatomy, Fujita Health University, School of Medicine, Aichi, Japan
    Neurosci Lett 271:53-6. 1999
    ..However, in our recent study, many LDTg neurons with MAO type B (MAOB)-activity were found in MAOA-deficient mice that were derived from C3H mouse line...
  48. pmc Genetic polymorphism of dopamine D2 receptors in Parkinson's disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism
    P Costa-Mallen
    Department of Environmental Health, University of Washington School of Public Health and Community Medicine, 4225 Roosevelt Way NE 100, Seattle, WA 98105 6099, USA
    J Neurol Neurosurg Psychiatry 69:535-7. 2000
    ..the MAO-B/DRD2 interaction did not reach statistical significance after Bonferroni correction for multiple comparisons, these results are suggestive of a possible synergism between MAOB and DRD2 genes with respect to Parkinson's disease.
  49. pmc Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris
    Anup K Upadhyay
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road NE, Atlanta, GA 30322, USA
    Protein Expr Purif 59:349-56. 2008
    ..Kinetic parameters obtained for purified rMAOB are compared with those reported earlier for recombinant human liver MAOB expressed in P. pastoris.
  50. doi Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B
    Giuseppe La Regina
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universita di Roma, Piazzale Aldo Moro 5, I 00185 Roma, Italy
    Bioorg Med Chem 16:9729-40. 2008
    ..However, only compound 22 was able to form hydrogen bonds with FAD, a finding which was in accordance with its potent anti-MAO-A activity. Conversely, 22/MAOB complex was highly unstable during the MD simulation.
  51. ncbi Increased stress response and beta-phenylethylamine in MAOB-deficient mice
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Nat Genet 17:206-10. 1997
    MAOA and MAOB are key iso-enzymes that degrade biogenic and dietary amines. MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA)...
  52. pmc Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice
    O U Scremin
    Department of Physiology, UCLA School of Medicine, Los Angeles, CA, USA
    Brain Res 824:36-44. 1999
    ..cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n=11) and the corresponding wild-type animals (WILD, n=11)...
  53. ncbi Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat
    Hideaki Kouzaki
    Department of Otolaryngology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Brain Res 1055:202-7. 2005
    A previous study demonstrated that monoamine oxidase type B (MAOB) mRNA is located in the inferior olive complex (IO)...
  54. ncbi Electron-microscopic study of MAOB-containing structures in the nucleus accumbens shell: using MAOA-deficient transgenic mice
    K Ikemoto
    Departement de Medecine Experimentale, INSERM U52, CNRS ERS 5645, Universite Claude Bernard, Lyon, France
    Brain Res 771:163-6. 1997
    b>MAOB-containing structures in the nucleus accumbens were ultrastructurally studied for the first time, using MAOA-deficient transgenic mice and MAO enzyme histochemistry...
  55. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
    ..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)...
  56. ncbi Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, Beijing 100083, People s Republic of China
    Neurosci Lett 407:107-11. 2006
    ..g., MAOA and MAOB) have been pursued as candidates for influencing risk for the disorder. HTR2C is also located on the X chromosome...
  57. ncbi Contiguous deletion of the NDP, MAOA, MAOB, and EFHC2 genes in a patient with Norrie disease, severe psychomotor retardation and myoclonic epilepsy
    L Rodriguez-Revenga
    Biochemistry and Molecular Genetics Department, Hospital Clinic, Barcelona, Spain
    Am J Med Genet A 143:916-20. 2007
    ..of a patient harboring a large submicroscopic deletion affecting not only the NDP gene but also the MAOA, MAOB, and EFHC2 genes...
  58. pmc Are metabolically normal but obese individuals at lower risk for all-cause mortality?
    Jennifer L Kuk
    School of Kinesiology and Health Science, York University, Toronto, Canada
    Diabetes Care 32:2297-9. 2009
    ..The clinical relevance of the metabolically normal but obese phenotype for mortality risk is unclear. This study examines the risk for all-cause mortality in metabolically normal and abnormal obese (MNOB and MAOB, respectively) individuals.
  59. ncbi Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice
    V L Rao
    Neuroscience Research Unit, André Viallet Clinical Research Center University of Montreal, Hopital Saint Luc, Que, Canada
    Neurosci Lett 170:27-30. 1994
    Activities of monoamine oxidases, MAOA and MAOB, were measured using radiometric assays in different brain regions of the sparse-fur (spf/Y) mouse, a model of congenital hyperammonemia resulting from an X-chromosomal defect of ornithine ..
  60. ncbi Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation
    Ivan Berlin
    Departement de Pharmacologie, Centre Hospitalo Universitaire Pitie Salpetriere, Paris, France
    Addiction 97:1347-54. 2002
    Previous research has shown that smokers have reduced brain and platelet monoamine oxidase B (MAOB) activity. This is probably due to some components of tobacco smoke. When smokers quit, MAOB activity returns to normal...
  61. pmc Monoamine oxidase a and B gene polymorphisms and negative and positive symptoms in schizophrenia
    Beatriz Camarena
    Posgrado de Ciencias Genómicas, Universidad Autonoma de la Ciudad de Mexico, 03100 Mexico, DF, Mexico Departmento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, 14370 Mexico, DF, Mexico
    ISRN Psychiatry 2012:852949. 2012
    ..We analyzed uVNTR and rs1137070, polymorphisms from MAOA and rs1799836 of MAOB genes to perform single SNP case-control association study in a sample of 344 schizophrenia patients and 124 ..
  62. ncbi Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease
    Matilde Yáñez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Curr Top Med Chem 13:1692-706. 2013
    ..In addition MAOB inhibition retards further deterioration of cognitive functions...
  63. pmc Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease
    Jolene Ooi
    Translational Laboratory in Genetic Medicine TLGM, Agency for Science, Technology and Research A STAR, 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore
    Mol Neurobiol 52:1850-61. 2015
    ..Altogether, this study demonstrates abnormal MAO expression and activity and suggests a potential use for MAO inhibitors in HD. ..
  64. pmc Clinical Outcomes in Patients with Parkinson's Disease Treated with a Monoamine Oxidase Type-B inhibitor: A Cross-Sectional, Cohort Study
    Khashayar Dashtipour
    School of Medicine, Loma Linda University, Loma Linda, California
    Pharmacotherapy 35:681-6. 2015
    ..g., dementia, hallucinations), dyskinesia, falls, and freezing of gait (FoG) in patients with Parkinson's disease (PD) who received monoamine oxidase type B inhibitors (MAOB-Is) compared with patients who had never received MAOB-Is.
  65. pmc Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope
    Shang Yi A Tsai
    Cellular Pathobiology Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224
    Proc Natl Acad Sci U S A 112:E6562-70. 2015
    ..Cocaine was found to suppress the gene expression of monoamine oxidase B (MAOB) in the brain of wild-type but not Sig-1R knockout mouse...
  66. doi Modification of the association between early adversity and obsessive-compulsive disorder by polymorphisms in the MAOA, MAOB and COMT genes
    N W McGregor
    Department of Psychiatry, Stellenbosch University, Tygerberg, South Africa Department of Genetics, Stellenbosch University, Stellenbosch, South Africa Electronic address
    Psychiatry Res 246:527-532. 2016
    ..pilot study investigated gene-by-environment interactions between childhood trauma and polymorphisms in the MAOA, MAOB and COMT genes in OCD...
  67. doi THE EFFECT OF LONG-TERM HINDLIMB UNLOADING ON THE EXPRESSION OF RISK NEUROGENES ENCODING ELEMENTS OF SEROTONIN-, DOPAMINERGIC SYSTEMS AND APOPTOSIS; COMPARISON WITH THE EFFECT OF ACTUAL SPACEFLIGHT ON MOUSE BRAIN
    E A Kulikova
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia Electronic address
    Neurosci Lett . 2017
    ..Gdnf, Cdnf), apoptotic factors (Bcl-xl, Bax), serotonin- and dopaminergic systems (5-HT2A, Maoa, Maob, Th, D1r, Comt), and compared the results with the data obtained on mice that spent one month in spaceflight on ..
  68. ncbi The Norrie disease gene maps to a 150 kb region on chromosome Xp11.3
    K B Sims
    Neuroscience Center Neurology, Massachusetts General Hospital East, Charlestown 02129
    Hum Mol Genet 1:83-9. 1992
    ..Analysis, using in addition two overlapping YAC clones from this region, allowed orientation of the MAOA and MAOB genes in a 5'-3'-3'-5' configuration...
  69. ncbi 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation
    A Y Deutch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510
    Brain Res 527:96-102. 1990
    ..and another pyridine neurotoxin, 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP), potently inhibited in vitro MAOB activity and in contrast weakly inhibited MAOA activity...
  70. ncbi Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system
    M J Rodriguez
    Unitat de Bioquimica, Institut d Investigacions Biomédiques August Pi i Sunye, Facultat de Medicina, Universitat de Barcelona, Spain
    Cell Tissue Res 304:215-20. 2001
    ..They show that both enzymes have a widespread distribution in the human body with a matching pattern in many, but not all tissues, and with strong differences from the pattern of distribution in rodents...
  71. ncbi Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer's disease patients
    Lina Emilsson
    Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Neurosci Lett 326:56-60. 2002
    ..The two monoamine oxidase (MAO) enzymes, monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB), are important in the metabolism of monoamine neurotransmitters...
  72. ncbi Molecular cloning of canine monoamine oxidase subtypes A (MAOA) and B (MAOB) cDNAs and their expression in the brain
    Chie Hashizume
    Laboratory of Veterinary Ethology, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 65:893-8. 2003
    ..we determined the full-length nucleotide sequences of cDNA for canine monoamine oxidase type A (MAOA) and type B (MAOB) genes that were isolated from the canine brain cDNA library...
  73. ncbi Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue
    Alicia K Smith
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Pharmacogenomics 7:387-94. 2006
    ..POMC), nuclear receptor subfamily 3, group C, member 1 (NR3C1), monoamine oxidase A (MAOA), monoamine oxidase B (MAOB), and tryptophan hydroxylase 2 (TPH2)...
  74. ncbi Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder
    Nela Pivac
    Rudjer Boskovic Institute, Division of Molecular Medicine, PO Box 180, HR 10002 Zagreb, Croatia
    J Affect Disord 103:131-8. 2007
    ..Platelet monoamine oxidase (MAO-B) has been associated with susceptibility to various psychiatric disorders, personality traits and behaviors...
  75. doi Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy
    Anup K Upadhyay
    Department of Biochemistry, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Biochemistry 47:1554-66. 2008
    ..to be unique among mammalian MAOs in having a non-conservative Glu-X-Lys mutation (X being 151 in MAOAs and 142 in MAOB's), which is suggested to be the reason for its monomeric structure. This hypothesis has been tested in this work...
  76. doi Hyperserotonemia in autism: activity of 5HT-associated platelet proteins
    Dubravka Hranilovic
    Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia
    J Neural Transm (Vienna) 116:493-501. 2009
    ..have measured the activity of two platelet 5HT-associated proteins: 5HT transporter (5HTT) and monoamine oxidase B (MAOB), and indirectly studied the activity of 5HT(2A) receptor (5HT(2A)r) in 15 hyperserotonemic (HS) and 17 ..
  77. pmc Down-regulated GABAergic expression in the olfactory bulb layers of the mouse deficient in monoamine oxidase B and administered with amphetamine
    Hsiang Shu Yin
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan, ROC
    Cell Mol Neurobiol 30:511-9. 2010
    This study explores primarily the role of the activity of monoamine oxidase B (MAOB) in the regulation of glutamic acid decarboxylase(67) (GAD(67)) expression in distinct layers of main olfactory bulb (OlfB), which links the limbic system...
  78. pmc Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese
    Yi Liang Wei
    Department of Forensic Science, School of Medicine, Xi an Jiaotong University Key Laboratory of Ministry of Public Health for Forensic Science, Xi an 710061, PR China
    Behav Brain Funct 7:42. 2011
    ..Polymorphisms of isoforms MAOA and MAOB have been implicated in the etiology of mental disorders such as schizophrenia...
  79. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
    ..5-HT is mainly mediated by monoamine oxidase (MAO)A and, in the absence of this enzyme, by its cognate isoenzyme MAOB. MAOA and A/B knockout (KO) mice display high 5-HT levels, particularly during early developmental stages...
  80. doi A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington's disease: looking for biomarkers
    Jolanta Krzyszton-Russjan
    Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Chelmska 30 34 Str, 00 725 Warsaw, Poland
    J Bioenerg Biomembr 45:71-85. 2013
    ..07; p = 0.0005) which encodes an outer mitochondrial membrane-bound enzyme called monoamine oxidase type B; TGM2 (FC = 1.8; p = 0.02) encoding a transglutaminase 2 that mediates cellular stress; SLC2A4 (FC = 1...
  81. doi Psychosis-proneness correlates with expression levels of dopaminergic genes
    P Grant
    Center for Psychobiology and Behavioral Medicine, Justus Liebig University Giessen, Otto Behaghel Str 10F, 35394 Giessen, Germany Electronic address
    Eur Psychiatry 29:304-6. 2014
    ..We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic ..
  82. doi Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males
    Barnali Chakraborti
    Manovikas Biomedical Research and Diagnostic Centre, Manovikas Kendra, 482 Madudah, Plot I 24, Sector J, EM Bypass, Kolkata, West Bengal 700107, India
    Prog Neuropsychopharmacol Biol Psychiatry 71:123-36. 2016
    ..Therefore, genes encoding monoamine oxidases A/B (MAOA/MAOB) received special attention as these genes are located on the X-chromosome and the gene products are responsible ..
  83. pmc Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type
    Nicola Chiarelli
    Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Bres6cia, Italy
    PLoS ONE 11:e0161347. 2016
    ..g., CFD, AQP9, COLEC12, KCNQ5, PRLR), and essential for redox balance (e.g., ADH1C, AKR1C2, AKR1C3, MAOB, GSTM5)...
  84. pmc Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1
    Wai K Wong
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089 9121, USA
    J Biol Chem 277:22222-30. 2002
    ..In this study, we have shown that phorbol 12-myristate 13-acetate (PMA) increases human MAO B, but not MAO A, gene expression...
  85. ncbi The FAD binding sites of human monoamine oxidases A and B
    Dale E Edmondson
    Department of Biochemistry and Chemistry, Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322 3050, USA
    Neurotoxicology 25:63-72. 2004
    ..details of the interactions of the covalent 8alpha-S-cysteinyl-FAD with the protein moiety in monoamine oxidase B (MAO B) based on the MAO B crystal structure are described...
  86. ncbi Fluorinated phenylcyclopropylamines. Part 4: effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines
    Song Ye
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Bioorg Med Chem 13:2489-99. 2005
    ..None of the tested 1-aryl-2-fluorocyclopropylamines exhibited significant inhibition of tyramine oxidase.
  87. doi Gene-gene interaction between FGF20 and MAOB in Parkinson disease
    X Gao
    Center for Genetic Epidemiology and Statistical Genetics, and Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 72:157-62. 2008
    The fibroblast growth factor 20 (FGF20) and monoamine oxidase B (MAOB) genes are associated with Parkinson Disease (PD) risk and both are in the dopamine bio-pathway...
  88. ncbi Monoamine oxidase and semicarbazide sensitive amine oxidase activities in normal and inflamed human dental pulp
    Tatyana Vavilova
    Moscow Medical Dental University, Moscow, Russia
    Med Sci Monit 15:BR289-292. 2009
    ..In other tissues SSAO is involved in oxidative stress and inflammation, but the role of MAO and SSAO in human pulp and changes of their activities in reversible pulpitis still remains poorly understood...
  89. doi Monoamine oxidase A down-regulation contributes to high metanephrine concentration in pheochromocytoma
    Eric Grouzmann
    Divisions of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Clin Endocrinol Metab 97:2773-81. 2012
    ..Because epinephrine and metanephrine are almost exclusively produced by the adrenal medulla, this suggests distinct CAT metabolism in chromaffin cells and pheochromocytes...
  90. doi Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients
    Tuba G Edgnülü
    Mugla School of Health Sciences, Muğla Sıtkı Koçman University, Mugla, Turkey
    Adv Clin Exp Med 23:901-6. 2014
    ..MAO (EC 1.4.3.4) has two isoenzymes known as MAOA and MAOB. A promoter polymorphism of a variable number of tandem repeats (VNTR) in the MAOA gene seems to affect MAOA ..
  91. doi An integrated approach for identifying priority contaminant in the Great Lakes Basin - Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern
    Shibin Li
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN, USA, 55804 National Research Council, U S Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, MN 55804, USA Electronic address
    Sci Total Environ 579:825-837. 2017
    ..receptor alpha1 (esr1), chemokine ligand 10 protein (CXCL10), tumor protein p53 (p53), and monoamine oxidase B (Maob), were identified as candidates for future assessments at these AOCs...
  92. pmc X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism
    H G Brunner
    Department of Human Genetics, University Hospital, Nijmegen, The Netherlands
    Am J Hum Genet 52:1032-9. 1993
    ..These data are compatible with a primary defect in the structural gene for MAOA and/or monoamine oxidase type B (MAOB)...
  93. ncbi Catechol-O-methyltransferase and Parkinson's disease
    Chun Hwi Tai
    Department of Neurology, National Taiwan University Hospital, Taipei
    Acta Med Okayama 56:1-6. 2002
    ..Our recent study suggests that the COMTL allele can interact with the MAOB gene to increase the occurrence of PD in Taiwanese...
  94. ncbi Enzyme sensor array for the determination of biogenic amines in food samples
    Jana Lange
    University of Greifswald, Institute for Chemistry and Biochemistry, Germany
    Anal Bioanal Chem 372:276-83. 2002
    ..A combination of a monoamine oxidase, a tyramine oxidase and a diamine oxidase (with specific activities sufficient for rapid detection) are immobilised each on a ..
  95. ncbi Evidence for a genetic association between monoamine oxidase A and restless legs syndrome
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    Neurology 59:215-9. 2002
    ..Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS)...
  96. ncbi Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors
    Jichun Ma
    Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Mol Biol 338:103-14. 2004
    ..Two subtypes of MAO, MAOA and MAOB, are similar in primary sequences but have unique substrate and inhibitor specificities...
  97. ncbi [The therapy of wearing-off]
    Miho Murata
    Department of Neurology, Musashi Hospital, National Center of Neurology and Psychiatry
    Nihon Rinsho 62:1716-9. 2004
    ..doses and use long half-life dopamine agonist(continuous stimulation of dopamine receptors), COMT inhibitor and MAOB inhibitor (prolongation of the half-life of levodopa and dopamine), and zonisamide (long-term increase of dopamine ..
  98. ncbi Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings
    M W Nash
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:33-7. 2005
    ..five microsatellite markers located within or nearby to five serotonin system genes (5HT2C, 5HT1D, 5HT1B, TPH1, and MAOB)...
  99. ncbi Changes in platelet monoamine oxidase activity, cholesterol levels and hyperactive behaviour in adolescents over a period of three years
    Evelyn Kiive
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu 50410, Estonia
    Neurosci Lett 384:310-5. 2005
    ..This longitudinal analysis provides preliminary evidence that changes in platelet MAO activity and cholesterol, which may reflect changes in central serotonergic activity are associated with attention deficit in adolescents...
  100. ncbi Real-time detection of L-glutamate released from C6 glioma cells using a modified enzyme-luminescence method
    S M Zakir Hossain
    Department of Advanced Nano and Biosciences, Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930 8555 Japan
    Anal Bioanal Chem 389:1961-6. 2007
    ..monitoring of dopamine release from nerve model cells by enzyme-catalyzed luminescence measurement with tyramine oxidase and peroxidase...
  101. pmc Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors
    Se Young Son
    Laboratory of Protein Crystallography, Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 105:5739-44. 2008
    ..Its two subtypes, MAOA and MAOB, are linked to several psychiatric disorders and therefore are interesting targets for drug design...

Research Grants11

  1. Role of Genotype and Maternal Smoking on Brain MAO A
    Joanna Fowler; Fiscal Year: 2009
    ..abstract_text> ..
  2. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2010
    ..encoding synthetic and catabolic enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  3. Reduced vesicular catecholamine storage mediates oxidant-induced neurotoxicity
    TONYA NICOLE TAYLOR; Fiscal Year: 2010
    ..Current therapies include L-DOPA administration, MAOB inhibitors, and DA agonists, which all increase the amount of DA signaling in the brain...
  4. Evan S Deneris; Fiscal Year: 2015
    ..have shown that Pet-1 is needed for the coordinate induction of genes (Tph2, AADC, Sert, Vmat2, Htr1A, Htr1B, MaoB) directly responsible for 5-HT synthesis, reuptake, autoinhibition and metabolism it is not known whether Pet-1&..
  5. PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    Jean Shih; Fiscal Year: 2001
    ..The tissue distribution of factor b will be studied by Northern analysis. Factor b polypeptide(s) will also be expressed in resting Jurkat cells to see if it can stimulate IL-2 production. ..
  6. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..Brain levels of the[unreadable] neuromodulator B-phenylethylamine (MAO B substrate) will be determined by[unreadable] Gas Chromatography/Mass Spectrometry (GC-MS)...
  7. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2008
    ..Co-regulators interacting with APJGR during agonist stimulated or basal state will be co-immuno-precipitated by AR or GR specific antibody. The validity and the function of identified protein(s) will be investigated. ..
  8. NMDA RECEPTORS, PROTEIN KINASE C, AND EXCITOTOXICITY
    David Lynch; Fiscal Year: 2002
    ..This systematic approach should provide critical information on the complete mechanisms of control of NMDA receptors by PKC and their significance in physiologic and pathophysiologic processes. ..
  9. Regulation of NMDA Receptors in Excitotoxicity by Calpain and FYN
    David Lynch; Fiscal Year: 2007
    ..abstract_text> ..
  10. Genome-wide association of common alleles with long-term diabetic complications
    Andrew Paterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..