MAOA

Summary

Gene Symbol: MAOA
Description: monoamine oxidase A
Alias: BRNRS, MAO-A, amine oxidase [flavin-containing] A, monoamine oxidase type A
Species: human

Top Publications

  1. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
  2. doi Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis
    Laura Filonzi
    Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy
    Neurogenetics 10:65-72. 2009
  3. ncbi Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
    David Huizinga
    Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
    Biol Psychiatry 60:677-83. 2006
  4. ncbi Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors
    Rickard L Sjoberg
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Vasteras, Sweden
    Am J Med Genet B Neuropsychiatr Genet 144:159-64. 2007
  5. ncbi The influence of four serotonin-related genes on decision-making in suicide attempters
    Fabrice Jollant
    Universite Montpellier 1, Montpellier, France
    Am J Med Genet B Neuropsychiatr Genet 144:615-24. 2007
  6. ncbi Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies
    Beatriz Camarena
    Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente México DF, Mexico DF, Mexico
    Neuropsychobiology 49:126-9. 2004
  7. ncbi MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis
    J Kim-Cohen
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Mol Psychiatry 11:903-13. 2006
  8. doi Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts
    Chia Chang Chien
    Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    World J Biol Psychiatry 11:409-16. 2010
  9. ncbi Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism
    L Ozelius
    Molecular Neurogenetics, E K Shriver Center, Waltham, Massachusetts 02254
    Genomics 3:53-8. 1988
  10. ncbi A regulatory monoamine oxidase a promoter polymorphism and personality traits
    Håkan Garpenstrand
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 46:190-3. 2002

Detail Information

Publications246 found, 100 shown here

  1. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species...
  2. doi Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis
    Laura Filonzi
    Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy
    Neurogenetics 10:65-72. 2009
    ..synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated...
  3. ncbi Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
    David Huizinga
    Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
    Biol Psychiatry 60:677-83. 2006
    A functional promoter polymorphism in monoamine oxidase A (MAOA) has been implicated as a moderating factor in the relationship between childhood maltreatment and later adolescent and adult antisocial behavior...
  4. ncbi Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors
    Rickard L Sjoberg
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Vasteras, Sweden
    Am J Med Genet B Neuropsychiatr Genet 144:159-64. 2007
    ..findings among boys show that interactions between a polymorphism in the monoamine oxidase A gene promoter region (MAOA-LPR) and psychosocial factors predict criminal activity...
  5. ncbi The influence of four serotonin-related genes on decision-making in suicide attempters
    Fabrice Jollant
    Universite Montpellier 1, Montpellier, France
    Am J Med Genet B Neuropsychiatr Genet 144:615-24. 2007
    ..Patients were genotyped for four serotonergic polymorphisms: 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997...
  6. ncbi Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies
    Beatriz Camarena
    Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente México DF, Mexico DF, Mexico
    Neuropsychobiology 49:126-9. 2004
    ..0, p = 0.005). Our findings may provide evidence of a candidate gene involved in obese subjects with a BMI >/=35 kg/m(2)...
  7. ncbi MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis
    J Kim-Cohen
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Mol Psychiatry 11:903-13. 2006
    ..research on adults has shown that a functional polymorphism in the promoter region of the monoamine oxidase A (MAOA) gene moderates the impact of childhood maltreatment on risk for developing antisocial behavior...
  8. doi Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts
    Chia Chang Chien
    Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    World J Biol Psychiatry 11:409-16. 2010
    To explore the involvement of variable number tandem repeat (VNTR) polymorphisms in the monoamine oxidase A (MAOA) promoter and exon 3 of the dopamine D4 receptor (DRD4) gene in heroin addiction modulate the vulnerability of individuals ..
  9. ncbi Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism
    L Ozelius
    Molecular Neurogenetics, E K Shriver Center, Waltham, Massachusetts 02254
    Genomics 3:53-8. 1988
    An essentially full-length cDNA clone for the human enzyme monoamine oxidase type A (MAO-A) has been used to determine the chromosomal location of a gene encoding it...
  10. ncbi A regulatory monoamine oxidase a promoter polymorphism and personality traits
    Håkan Garpenstrand
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 46:190-3. 2002
    b>Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders...
  11. ncbi MAOA and persistent, pervasive childhood aggression
    J H Beitchman
    Mol Psychiatry 9:546-7. 2004
  12. ncbi An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1498-505. 2004
    Monoamine oxidase A (MAOA) activity is altered in mood disorders and lower activity associated with aggressive behavior...
  13. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia...
  14. ncbi Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders
    Blanca Gutierrez
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Psychiatr Genet 14:203-8. 2004
    Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and ..
  15. pmc MAOA haplotypes associated with thrombocyte-MAO activity
    Marten Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Genet 6:46. 2005
    ..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)...
  16. ncbi Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients
    Susan E Young
    Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
    Am J Psychiatry 163:1019-25. 2006
    ....
  17. ncbi The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
    ..Parenting characteristics have been shown to influence development of antisociality, moderated by variation at the MAOA gene, which has also been associated with the risk for substance use disorders...
  18. doi High activity of monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees
    Esther J M van der Vegt
    Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    Psychiatr Genet 19:209-11. 2009
    ..Our results suggest that in severely maltreated children, high MAO-A activity may not protect against the effects of maltreatment but may convey an increased risk for externalizing behaviour...
  19. pmc Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    J Neural Transm (Vienna) 116:1323-34. 2009
    Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect...
  20. doi MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption
    Kent W Nilsson
    Centre for Clinical Research, Central Hospital, Vasteras, S 721 89 Västerås, Sweden
    Addict Biol 16:347-55. 2011
    The aim of the present study was to investigate MAOA gene-environment (G*E) interactions in relation to adolescent alcohol consumption...
  21. pmc X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism
    H G Brunner
    Department of Human Genetics, University Hospital, Nijmegen, The Netherlands
    Am J Hum Genet 52:1032-9. 1993
    ..A maximal multipoint lod score of 3.69 was obtained at the monoamine oxidase type A (MAOA) locus in Xp11.23-11.4...
  22. ncbi Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
    H G Brunner
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Science 262:578-80. 1993
    ..This syndrome was associated with a complete and selective deficiency of enzymatic activity of monoamine oxidase A (MAOA)...
  23. ncbi Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (T
    I Manor
    Geha Mental Health Center, Petak Tikvah, Israel
    Mol Psychiatry 7:626-32. 2002
    Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin...
  24. ncbi Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity
    Luca Passamonti
    Neurology Unit, Department of Neurosciences, University Politecnica delle Marche, Ancona, Italy
    Biol Psychiatry 59:334-40. 2006
    ..High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers...
  25. ncbi Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males
    Ying Jin
    Peking University Stem Cell Research Center, Beijing Anding Hospital Affiliated Capital University of Medical Sciences, China
    Int J Neuropsychopharmacol 9:557-64. 2006
    ..We investigated the association between MAOA polymorphisms (a VNTR polymorphism and an EcoRV polymorphism) and smoking status...
  26. pmc Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway
    Xiao Ming Ou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 103:10923-8. 2006
    Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death...
  27. ncbi The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
    Shai Rosenberg
    Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 120:447-59. 2006
    Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues...
  28. ncbi Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 17:867-72. 2007
    The genes of catalytic enzymes of dopamine, including monoamine oxidase (MAOA and MAOB) and catechol-O-methyltransferase (COMT), have been major candidates for genes that affect smoking behavior...
  29. doi Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome
    Francesco Nonnis Marzano
    Department of Evolutionary and Functional Biology, University of Parma, 43100 Parma, Italy
    Genomics 91:485-91. 2008
    ..frequencies of TPH2, 5-HTTLPR, the 5-HTT (SLC6A4) intron 2 variable-number tandem repeat (VNTR) region, and the MAOA VNTR region were determined in brain-stem samples of 20 "genuine" SIDS cases and compared with results obtained ..
  30. doi A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, Australia
    Neuropsychopharmacology 34:1797-809. 2009
    Association studies suggest that the low activity variant of the monoamine oxidase A (MAOA)-uVNTR polymorphism confers risk for emotional disturbances associated with antisocial traits, particularly in males...
  31. ncbi Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain
    J Saura
    F Hoffmann La Roche Ltd, Pharma Division, Basel, Switzerland
    J Neurosci 12:1977-99. 1992
    ..The physiological roles of the enzymes are discussed in the light of these findings, some of which were unexpected.(ABSTRACT TRUNCATED AT 400 WORDS)..
  32. ncbi Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  33. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment...
  34. ncbi Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
    Deborah C Lawson
    Department of Psychologycal Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:84-9. 2003
    ..Monoamine Oxidase A (MAOA) is involved in the degradation of all three of these neurotransmitters and therefore has been suggested as a ..
  35. pmc Mapping the genetic variation of executive attention onto brain activity
    Jin Fan
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7406-11. 2003
    ..We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time ..
  36. ncbi Association of autism severity with a monoamine oxidase A functional polymorphism
    I L Cohen
    Departments of Psychology, Cytogenetics and Human Genetics, Staten Island, New York 10314, USA
    Clin Genet 64:190-7. 2003
    A functional polymorphism (the upstream variable-number tandem repeat region, or uVNTR) in the monoamine oxidase A (MAOA) promoter region has been reported to be associated with behavioral abnormalities as well as increased serotonergic ..
  37. ncbi Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females
    Younger W Y Yu
    Yu s Psychiatric Clinic, Taiwan, ROC
    Neuropsychobiology 52:77-82. 2005
    Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans...
  38. ncbi Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S 721 89 Västerås, Sweden
    Biol Psychiatry 59:121-7. 2006
    ..The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity...
  39. ncbi The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
    K Brookes
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, UK
    Mol Psychiatry 11:934-53. 2006
    ..for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT...
  40. ncbi The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Vasteras, Sweden
    Addiction 102:389-98. 2007
    ..To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents...
  41. pmc Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence
    San Yuan Huang
    Department of Psychiatry, Tri Service General Hospital, Taiwan, ROC
    J Psychiatry Neurosci 32:185-92. 2007
    ..Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.
  42. ncbi Meta-study on association between the monoamine oxidase A gene (MAOA) and schizophrenia
    Dawei Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Am J Med Genet B Neuropsychiatr Genet 147:174-8. 2008
    The human monoamine oxidase A gene (MAOA) has attracted considerable attention as a candidate gene for schizophrenia based both on its chromosomal position and its enzyme function as a key factor in neurotransmitter catabolism pathways...
  43. ncbi The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S 721 89, Vasteras, Sweden
    Drug Alcohol Depend 93:51-62. 2008
    ....
  44. pmc MAOA methylation is associated with nicotine and alcohol dependence in women
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:565-70. 2008
    ..One prominent locus at which epigenetic phenomena are thought to be in play is the monoamine oxidase A (MAOA) locus...
  45. doi The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia
    A Reif
    Department of Psychiatry and Psychotherapy, Section of Clinical and Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Neurol 15:637-9. 2008
    ..FTD patients and 151 controls matched to age and genotyped them for a functional promoter polymorphism, termed MAOA-uVNTR. However, no significant differences were observed between patients and controls...
  46. pmc Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females
    E C Prom-Wormley
    Department of Integrative Life Sciences, Virginia Commonwealth University 23298 0126, USA
    Psychol Med 39:579-90. 2009
    ..have reported a genotype-environment interaction (GxE) in which low-activity alleles at the monoamine oxidase A (MAOA) locus conferred greater sensitivity to the effects of childhood adversity on risk for conduct disorder (CD)...
  47. pmc Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo
    Brian J Mickey
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 28:11354-9. 2008
    ..These results demonstrate a sex-specific interaction between two key molecules of the human serotonergic system, and suggest a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes...
  48. pmc Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior
    L S Wakschlag
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60608, USA
    Mol Psychiatry 15:928-37. 2010
    ..We tested whether a functional polymorphism in the gene encoding the enzyme monoamine oxidase A (MAOA) interacts with exposure to predict pathways to adolescent antisocial behavior...
  49. pmc MAOA-uVNTR and early physical discipline interact to influence delinquent behavior
    Alexis C Edwards
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    J Child Psychol Psychiatry 51:679-87. 2010
    A functional polymorphism in the promoter region of the monoamine oxidizing gene monoamine oxidase A (MAOA) has been associated with behavioral sensitivity to adverse environmental conditions in multiple studies (e.g., Caspi et al...
  50. pmc Targeting monoamine oxidase A in advanced prostate cancer
    Vincent Flamand
    Department of Urology, Stanford Medical Center, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
    J Cancer Res Clin Oncol 136:1761-71. 2010
    Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression...
  51. pmc Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 5:325-42. 2010
    Monoamine oxidase A (MAO A) is an enzyme that catalyzes the oxidation of neurotransmitter amines. A functional polymorphism in the human MAOA gene (high- and low-MAOA) has been associated with distinct behavioral phenotypes...
  52. doi Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study
    Gil Zalsman
    Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel
    World J Biol Psychiatry 12:33-41. 2011
    ..Suicidal behaviour runs in families. This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents.
  53. pmc Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development
    T Ziermans
    Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Transl Psychiatry 2:e85. 2012
    ..polymorphisms (SNPs) located in six dopaminergic candidate genes (COMT, SLC6A3/DAT1, DBH, DRD4, DRD5, MAOA)...
  54. ncbi Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat
    R M Denney
    Department of Human Biological Chemistry and Genetics, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston 77555 0650, USA
    Hum Genet 105:542-51. 1999
    ..2 kb upstream from MAOA exon 1 (uVNTR)...
  55. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
    ....
  56. ncbi Monoamine oxidase polymorphisms and smoking behaviour in Japanese
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya Aichi 464 8681, Japan
    Pharmacogenetics 13:73-9. 2003
    ..These findings among male smokers support the view that MAO affects a smokers' requirement for nicotine and may explain why some people are predisposed to tobacco addiction and why some individuals find it difficult to stop smoking...
  57. ncbi Investigation of serotonin-related genes in antidepressant response
    E J Peters
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Mol Psychiatry 9:879-89. 2004
    ..genotyped patients at 110 SNPs and four repeat polymorphisms located in seven candidate genes (HTR1A, HTR2A, HTR2C, MAOA, SLC6A4, TPH1, and TPH2)...
  58. ncbi Obesity is associated with genetic variants that alter dopamine availability
    A C Need
    Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT
    Ann Hum Genet 70:293-303. 2006
    ..Dopamine availability is controlled largely by three enzymes: COMT, MAOA and MAOB, and by the dopamine transporter SLC6A3, and each gene has a well-characterized functional variant...
  59. ncbi Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
    J W Buckholtz
    Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Mol Psychiatry 13:313-24. 2008
    ..To identify these circuits, we used a combined genetic and imaging approach focused on Monoamine Oxidase A (MAOA), encoding a key enzyme for monoamine metabolism previously associated with temperament and antisocial behavior...
  60. pmc Association study between clinical response to rizatriptan and some candidate genes
    Carlo Asuni
    Section of Clinical Pharmacology, Department of Neurosciences B B Brodie, University of Galiari, P O San Giovanni di Dio, Via Ospedale 46, I 09124 Cagliari, Italy
    J Headache Pain 8:185-9. 2007
    ..These genetic differences could be explained by various genes, the HTR1B, encoding the 5-HT(1) receptor subtype, MAOA gene that encodes the monoamino-oxidase, the main metabolic enzyme of this triptan, SLC6A4 (gene encoding the ..
  61. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    ..among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality...
  62. pmc Genes implicated in serotonergic and dopaminergic functioning predict BMI categories
    Bernard F Fuemmeler
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Obesity (Silver Spring) 16:348-55. 2008
    ..with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as ..
  63. pmc A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)
    Meredith S Shiels
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Prev Med 47:116-22. 2008
    ..The association between common polymorphisms of these genes and smoking behavior was assessed among 10,059 Caucasian volunteers in Washington County, MD in 1989...
  64. doi Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036 8562 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1932-5. 2008
    ..between a polymorphism involving a variable number of tandem repeats in the promoter of the monoamine oxidase A (MAOA-VNTR) gene and personality traits, as assessed by the Temperament and Character Inventory (TCI)...
  65. doi MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder
    Ana P Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Neuropsychopharmacol 12:709-14. 2009
    The monoamine oxidase A (MAOA) gene has been extensively related to aggressive, impulsive and violent behaviours...
  66. doi MAOA gene polymorphisms and response to mirtazapine in major depression
    Dong Sheng Tzeng
    Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan
    Hum Psychopharmacol 24:293-300. 2009
    Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD).
  67. doi Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population
    Hai Tang Qiu
    Department of Mental Health, First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Brain Res 1287:67-73. 2009
    ..Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder...
  68. doi Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder...
  69. pmc The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:619-28. 2010
    ..using lymphoblast DNA prepared from 192 subjects from the Iowa Adoption Studies (IAS) demonstrated that decreased MAOA promoter methylation was associated with lifetime symptom count for nicotine dependence (ND) and provided ..
  70. pmc Monoamine oxidase A gene (MAOA) associated with attitude towards longshot risks
    Songfa Zhong
    Center for Experimental Business Research and Department of Economics, Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region, Hong Kong
    PLoS ONE 4:e8516. 2009
    ..association with a widely studied, promoter-region repeat functional polymorphism in monoamine oxidase A gene (MAOA)...
  71. doi Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Int Rev Neurobiol 100:85-106. 2011
    ..The roles of MAO-A in the regulation of neuronal survival and death are discussed in concern to find a novel strategy to protect neurons in age-associated neurodegenerative disorders and depression...
  72. pmc The monoamine oxidase A gene promoter repeat and prostate cancer risk
    Thomas A White
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 72:1622-7. 2012
    Amine catabolism by monoamine oxidase A (MAOA) contributes to oxidative stress, which plays a role in prostate cancer (PCa) development and progression...
  73. pmc Human monoamine oxidase A and B genes exhibit identical exon-intron organization
    J Grimsby
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033
    Proc Natl Acad Sci U S A 88:3637-41. 1991
    Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3...
  74. ncbi Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease
    E R Levy
    Genetics Laboratory, Department of Biochemistry, Oxford, United Kingdom
    Genomics 5:368-70. 1989
    ..23-11.4. As restriction fragments detected by this probe are deleted in some patients with Norrie disease, this assignment provides confirmation of the localization of the disease...
  75. ncbi Assignment of genes for human monoamine oxidases A and B to the X chromosome
    L M Kochersperger
    J Neurosci Res 16:601-16. 1986
    ..or human MAO B, but not the corresponding mouse enzymes, were used to assay for the presence of immunoprecipitable MAO A or MAO B (presumably coded by the respective human genes) in mouse-human hybrid somatic cell lines containing ..
  76. ncbi No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides
    Hisae Ono
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Kobe, Japan
    Am J Med Genet 114:340-2. 2002
    Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide...
  77. ncbi No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Prog Neuropsychopharmacol Biol Psychiatry 26:457-61. 2002
    A positive association of MAOA polymorphisms with alcoholism has been demonstrated in certain recent studies, however, this association is not universally supported...
  78. ncbi Association of monoamine oxidase A gene polymorphism with Alzheimer's disease and Lewy body variant
    Masanori Takehashi
    Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Neurosci Lett 327:79-82. 2002
    The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined...
  79. ncbi High activity-related allele of MAO-A gene associated with depressed suicide in males
    Lisheng Du
    Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 13:1195-8. 2002
    ..The results thus provide further evidence that genetic factors can modulate risk for depression, suicide or both by influencing monoaminergic activity in sexually dimorphic manner...
  80. ncbi Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
    ..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD...
  81. ncbi Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression
    A Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 117:1-6. 2003
    ..to detect a possible association of a T941G single nucleotide polymorphism (SNP) in the monoamine oxidase A (MAOA) gene with generalized anxiety disorder (GAD), panic disorder (PD), or major depression (MD)...
  82. ncbi MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males
    Lisheng Du
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Ave, Ontario K1Z 7K4, Canada
    Neuroreport 15:2097-101. 2004
    ..These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients...
  83. ncbi Monoamine oxidases A and B gene polymorphisms in migraine patients
    Vedrana Filic
    Laboratory of Neurochemistry and Molecular Neurobiology, Dept of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, Zagreb HR 10000, Croatia
    J Neurol Sci 228:149-53. 2005
    ..The suggestive association of the variant in MAO-A gene with migraine is considered worthy of independent replication. On the other hand, further studies on MAO-B polymorphism in migraine do not seem promising...
  84. ncbi Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 135:59-64. 2005
    ..Animal and human studies suggest that variation in monoamine oxidase A (MAOA) genotype may moderate the effects of maltreatment...
  85. ncbi Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taiwan, ROC
    Neuropsychopharmacology 30:1719-23. 2005
    Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of biogenic amines, may be implicated in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants...
  86. ncbi Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?
    Agnes L Nishimura
    Human Genome Research Center, Biology Department, Institute of Biosciences, São Paulo University IBUSP, Sao Paulo, Brazil
    J Mol Neurosci 27:213-7. 2005
    ..Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls...
  87. ncbi Monoallelic expression of MAOA in skin fibroblasts
    Niklas Nordquist
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Biochem Biophys Res Commun 348:763-7. 2006
    ..Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences...
  88. ncbi Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors
    Julia K Pinsonneault
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
    Hum Mol Genet 15:2636-49. 2006
    A pVNTR repeat polymorphism located in the promoter region of the X-linked MAOA gene has been associated with mental disorders...
  89. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes...
  90. ncbi Monoamine oxidase a gene is associated with borderline personality disorder
    Xingqun Ni
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatr Genet 17:153-7. 2007
    ..As for its role in aggression, impulsivity, suicide and mood liability, monoamine oxidase A can be considered a functional candidate in borderline personality disorder...
  91. ncbi Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women
    F Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Mol Psychiatry 13:334-47. 2008
    ..Among male subjects, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter region of the monoamine oxidase A gene (MAOA) ..
  92. ncbi [Genetic basis of time perception in athletes]
    G V Portnova
    Zh Vyssh Nerv Deiat Im I P Pavlova 57:450-60. 2007
    ..5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow...
  93. pmc The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity
    Guang Guo
    Department of Sociology, Carolina Center for Genome Sciences, Carolina Population Center, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 3210, USA
    Eur J Hum Genet 16:626-34. 2008
    ..in the United States, the present study demonstrates a link between the rare 2 repeat of the 30-bp VNTR in the MAOA gene and much higher levels of self-reported serious and violent delinquency...
  94. pmc Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Monit 14:CR57-61. 2008
    The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. A polymorphism in the promoter region (MAOA-uVNTR) affects transcriptional efficiency...
  95. doi MAOA and the neurogenetic architecture of human aggression
    Joshua W Buckholtz
    Vanderbilt Brain Institute and Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Trends Neurosci 31:120-9. 2008
    ..are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent...
  96. doi Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex
    Luca Passamonti
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, 87050, Italy
    Neuroimage 40:1264-73. 2008
    ..Although with conflicting findings, the monoamine oxidase-A (MAOA) and the serotonin transporter (5HTT) gene polymorphisms have been associated with an increased risk to develop ..
  97. doi Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation
    Antonio Cerasa
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    Brain Res 1201:114-21. 2008
    ..The X-linked Mono-Amine Oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin (5-HT) catabolism, presents a well-characterized ..
  98. pmc Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
    Yi Mei J Lin
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
    Behav Brain Funct 4:21. 2008
    Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin...
  99. doi Differential association between MAOA, ADHD and neuropsychological functioning in boys and girls
    Nanda N J Rommelse
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1524-30. 2008
    ..been hypothesized that this sex difference might be related to genes on the X-chromosome, like Monoamine Oxidase A (MAOA)...
  100. doi Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism
    Camilla Gokturk
    Department of Neuroscience, Pharmacology, Uppsala University, Uppsala, Sweden
    Arch Womens Ment Health 11:347-55. 2008
    ..in the promoter region of the serotonin transporter and monoamine oxidase-A, respectively, (5-HTT-LPR and MAOA-VNTR), was performed in a group of women with severe alcohol addiction...
  101. pmc Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation
    Rose McDermott
    Department of Political Science, Brown University, 36 Prospect Street, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 106:2118-23. 2009
    Monoamine oxidase A gene (MAOA) has earned the nickname "warrior gene" because it has been linked to aggression in observational and survey-based studies...

Research Grants70

  1. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..These genes include MAOA, XIST. ELF4, FACL4; PLP1, PPEF1, SYP, SYNl, BGN, and TBLl...
  2. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..OCD; b) linkage using affected-relative pairs to 4 candidate gene regions (SLC6A4-serotonin transporter, COMT, MAOA, DRD4) using 3 SNP biallelic markers and 4 flanking microsatellite markers; c) complex segregation analysis to ..
  3. Machine Learning for Analysis of functional MRI of Underlying Inhibitory Control
    Dimitrios Samaras; Fiscal Year: 2010
    ..spatial brain pattern will indicate a diagnosis of drug addiction and a membership in one or another level ol MAOA genotype...
  4. Nelly Alia-Klein; Fiscal Year: 2014
    ..Specifically, monoamine oxidase A (MAO A), an enzyme regulating the neurotransmitters serotonin and norepinephrine, has been reliably implicated in ..
  5. Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..in rhesus monkey serotonin transporter (SERT), tryptophan hydroxylase 2 (TPH2) and monoamine oxidase A (MAOA) genes, and assess genotype/phenotype relationships relevant to drug addiction, alcoholism and neuropsychiatric ..
  6. Eric J Vallender; Fiscal Year: 2014
    ..This will concentrate initially on monoamine oxidase A (MAOA)...
  7. Epigenetic Regulation of Serotonin:Relevance to HIV and Methamphetamine Abuse
    GREGORY MICHAEL MILLER; Fiscal Year: 2012
    ..the key modulators of the serotonin system, including the serotonin transporter (5-HTT), monoamine oxidase A (MAOA) and tryptophan hydroxylase 2 (TPH2) have been well-documented, epigenetic regulation of these genes is poorly ..
  8. Epigenetic Status of MAOA Gene as a Module of Translational Behavioral Research
    Elena Shumay; Fiscal Year: 2013
    ..Subsequer individual's methylation pattern will be linked to their brain imaging data measuring the amount of MAO A acti data will be(used to determine if there is a correlation between methylation of the MAOA gene and the amoun ..
  9. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ..from five carefully selected regions - the serotonin transporter gene (SLC6A4), the monoamine oxidase A gene (MAOA), the catechol-O-methyltransferase gene (COMT), the type 4 dopamine receptor gene (DRD4), and a series of tag SNPs ..
  10. Gene x Environment Interactions Predicting an Endophenotype for Depression
    Caroline Oppenheimer; Fiscal Year: 2012
    ..genes: the serotonin transporter gene (5-HTTLPR), the dopamine D2 receptor gene (DRD2), and monoamine oxidase A (MAOA)...
  11. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..The observation that greater cocaine sensitivity is associated with reduced D2R or MAO A expression seems counterintuitive...
  12. Neurogenetics of serotonin regulation: building naturalistic rhesus monkey models
    Gregory Miller; Fiscal Year: 2009
    ..functional polymorphisms in tryptophan hydroxylase 2 (TPH2), serotonin transporter (SERT) and monoamine oxidase A (MAOA) genes in an effort to more accurately model serotonergic neurogenetic variance associated with human mental health ..
  13. Modeling the Neurogenetics of Serotonin Regulation
    ERIC VALLENDER; Fiscal Year: 2009
    ..application seeks to explore the neurogenetic diversity of serotonin transporter (SERT) and Monoamine Oxidase A (MAOA) genes in rhesus monkeys...
  14. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2013
    ..The proposed project aims to comprehensively test several genes in the serotonin pathway (SLC6A4, MAOA, TPH1, TPH2, HTR1A, HTR1B, HTR2A, HTR2C) and genes of inflammatory markers (ILIp, IL6, CRP, TNFa, SELE, SELP, ICAM ..
  15. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
    ..The proposed research project aims to comprehensively test genes in the serotonin pathway (SLC6A4, MAOA, TPH1, TPH2, HTR1A, HTR1B, HTR2A, HTR2C) and inflammatory marker genes (IL1B, IL6,TNFa, CRP, SELE, SELF, ICAM1, ..
  16. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2010
    ..pathways, encoding synthetic and catabolic enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  17. Mari S Golub; Fiscal Year: 2015
    ..genetic screening at our primate center (CNPRC) allows selection of subgroups of monkeys with low and high activity MAOA gene polymorphisms...
  18. NATHANIEL ERIK ANDERSON; Fiscal Year: 2015
    ..Specifically, 5HTT, MAOA, DAT, DRD2, and DRD4 are featured prominently in this literature and impact monoaminergic signaling pathways ..
  19. Gene-Environment Interplay, Development, and Emotional Disorders
    William Copeland; Fiscal Year: 2012
    ..to study gene-environment interaction models for (1) promising genetic markers include HTTLPR, HTR2A T102C, MAOA-u VNTR, BDNF va!66met and COMT val158met and additional markers identified based upon the results of psychiatric ..
  20. Development of Adolescent Depression: Genes, Temperament and Gender Differences
    Heather A Priess; Fiscal Year: 2010
    ..Specific aims are: 1) Examine whether the short allele of 5-HTTLPR and the three-repeat allele of MAOA- uVNTR, in interaction with negative life events, predict more depressive symptoms and disorders in adolescence;2) ..
  21. DEREK F BEATON; Fiscal Year: 2015
    ..Additionally, I have identified several possibly protective markers related to the BDNF and MAOA genes.
  22. THE NEUROBIOLOGY OF SUICIDAL BEHAVIOR
    JOSEPH MANN; Fiscal Year: 2009
    ..Effects of susceptibility gene expression on binding to 5-HTT, 5-HTiA and MAOA will be determined by PET and related to depression and suicidal behavior...
  23. Gene x Environment Factors in Smoking Cessation
    Andrew Hyland; Fiscal Year: 2007
    ..factors including the following genes: DRD2 and DRD4 (dopamine receptor); SLC6A3 (dopamine transporter); DBH, COMT, MAOA (dopamine metabolism); 5-HTT (serotonin transporter), and CYP2A6, CYP2B6, and CYP2D6 (nicotine metabolism)...
  24. Dependence of the Development of Attention on Genotype
    John Fossella; Fiscal Year: 2009
    ..of several dopaminergic genes that have been associated with developmental disabilities showed that the DRD4 and MAOA genes showed associations with efficiency of executive attention and that frontal midline regions including the ACC ..
  25. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  26. A thyroid receptor co-activator hypothesis for psychosis
    Robert Philibert; Fiscal Year: 2005
    ..The net effect will be to produce an independent investigator capable of functional and translational research. ..
  27. Substance Use Disorder Liability: Candidate Gene System
    Michael Vanyukov; Fiscal Year: 2008
    ..abstract_text> ..
  28. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ..These analyses will consider polymorphisms in SLC6A3, DRD4, DRD2, SLC6A4, & MAOA as well as measures of religiosity and other social and demographic context including family structure, parental ..
  29. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2004
    ..Among these loci, the genes encoding dopamine receptors and monoamine oxidase A (MAOA) attract special attention because of their demonstrated or hypothesized involvement in the risk for substance ..
  30. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  31. Intergenerational Transmission of Neglect and Abuse
    CATHY WIDOM; Fiscal Year: 2009
    ..Given the increasing interest in understanding the "mind-body" connection, this assessment of biomeasures in the G3 offspring may provide further insight into the impact of these childhood experiences. ..
  32. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  33. TREATING OPPOSITIONAL DEFIANT BEHAVIOR
    JOHN LAVIGNE; Fiscal Year: 2001
    ....
  34. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2002
    ....
  35. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
    ....
  36. Psychobiologic Factors of the Placebo Response in MDD
    Andrew Leuchter; Fiscal Year: 2007
    ..The results of this project will lead to better understanding of the mechanisms of the placebo response in MDD. ..
  37. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  38. PREVENTIVE INTERVENTION--TODDLERS OF DEPRESSED MOTHERS
    Dante Cicchetti; Fiscal Year: 2003
    ..This investigation also will increase understanding of the developmental contributors to psychopathological outcomes in offspring of depressed mothers. ..
  39. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  40. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    ..Relevance ..
  41. SIMIAN AIDS: SOCIAL STRESS, ENDOCRINE & IMMUNE FUNCTION
    John Capitanio; Fiscal Year: 2004
    ..abstract_text> ..
  42. ENHANCING TREATMENT OUTCOMES IN DEPRESSION
    Andrew Leuchter; Fiscal Year: 2004
    ..These effectiveness projects will include introduction of predictors into the usual treatment setting, and examination of cost-effectiveness and long-term treatment outcomes. ..
  43. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2003
    ..This application is the resubmission of a prior proposal of the same title. ..
  44. AN ECOGENETIC STUDY OF ADHD
    Stephen Faraone; Fiscal Year: 2003
    ..Furthermore, no studies have used an ecogenetic approach to sharpen the accuracy of risk prediction. ..
  45. TEEN DRUG USE/ABUSE: PATHWAYS FROM CHILD MALTREATMENT
    Dante Cicchetti; Fiscal Year: 2004
    ..Psychopathology and problem adolescent behaviors also will be assessed. ..
  46. CHILDHOOD VICTIMIZATION AND LIFETIME REVICTIMIZATION
    Cathy Spatz Widom; Fiscal Year: 2003
    ..Assessing lifetime and current rates provides two different perspectives on revictimization probabilities and, together, provides a comprehensive picture of one important consequence of childhood victimization. ..
  47. Drug Cue Reactivity in Smokers: An fMRI Investigation
    Francis McClernon; Fiscal Year: 2002
    ..The results of this study will enhance our understanding of the neurobiological basis of tobacco dependence, inform treatment development, and generate additional hypotheses and research plans. ..
  48. TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
    Stephen Faraone; Fiscal Year: 2002
    ..Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder. ..
  49. PREVENTIVE INTERVENTION FOR MALTREATED INFANTS
    Dante Cicchetti; Fiscal Year: 2002
    ....
  50. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  51. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
  52. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  53. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  54. Validating Novel Familial Phenotypes of Drug Abuse
    Stephen Faraone; Fiscal Year: 2007
    ..State of the art statistical techniques will be employed. ..
  55. ODD/Depression in young children: Developmental aspects
    JOHN LAVIGNE; Fiscal Year: 2008
    ..abstract_text> ..
  56. Analysis of an ADHD Whole Genome Association Scan
    Stephen Faraone; Fiscal Year: 2007
    ..All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. [unreadable] [unreadable] [unreadable]..
  57. International Multi-Center ADHD Genetics Project
    Stephen Faraone; Fiscal Year: 2007
    ..abstract_text> ..
  58. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2008
    The long-term objective of this project is to understand the role of monoamine oxidase A (MAO A) in mental disorders. MAO A is the key enzyme, which degrades serotonin (5-HT)...
  60. Genome-wide association of common alleles with long-term diabetic complications
    Andrew Paterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  61. Improving medication use for ADHD in primary care
    JOHN LAVIGNE; Fiscal Year: 2008
    ..Following an intent-to-treat model, a minimum of 468 children (234 SC; 234 TAU) will be recruited and complete all evaluations in the intensive training phase. ..
  62. Searching for ADHD Susceptibility Genes
    Stephen V Faraone; Fiscal Year: 2010
    ..That, in turn, should facilitate the search for newer, more effective treatments for the disorder. ..
  63. 2/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Stephen Faraone; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  64. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..The specific aims are outlined below:[unreadable] [unreadable] To study the function of both MAO A and B in neurotransmitter metabolism and[unreadable] behavior using double knock-out (KO) mice MAO A and B (A/B) ..
  65. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..The WNT2 findings will be further examined in two-independent patient samples. ..
  66. Child Abuse and Neglect, Chronic Stress, and Drug Abuse
    Cathy Spatz Widom; Fiscal Year: 2005
    ....
  67. STRESS, SEROTONIN GENE & HEALTH DISPARITIES
    Redford Williams; Fiscal Year: 2004
    ..In addition to increasing understanding of biobehavioral mechanisms responsible for health disparities, the findings could point to targets for specific interventions aimed at ameliorating these disparities. ..
  68. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  69. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..