LTA

Summary

Gene Symbol: LTA
Description: lymphotoxin alpha
Alias: TNFB, TNFSF1, TNLG1E, lymphotoxin-alpha, LT-alpha, TNF superfamily, member 1, TNF-beta, tumor necrosis factor beta, tumor necrosis factor ligand 1E, tumor necrosis factor ligand superfamily member 1
Species: human

Top Publications

  1. ncbi Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation
    D W Banner
    F Hoffmann La Roche Limited, Pharmaceutical Research New Technologies, Basel, Switzerland
    Cell 73:431-45. 1993
  2. ncbi Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy
    M Nishimura
    Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan
    Hum Immunol 61:1262-9. 2000
  3. ncbi Role of IL-6, TNF-A and LT-A variants in the modulation of the clinical expression of plaque-induced gingivitis
    Chiara Scapoli
    Department of Biology and Evolution, and Research Center for the Study of Periodontal Diseases, University of Ferrara, Via Luigi Borsari 46, Ferrara, Italy
    J Clin Periodontol 34:1031-8. 2007
  4. doi Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components
    Catherine M Phillips
    Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Clin Endocrinol Metab 95:1386-94. 2010
  5. ncbi Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes
    P Selvaraj
    Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, 600 031, India
    Tuberculosis (Edinb) 81:335-41. 2001
  6. doi Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:141-50. 2009
  7. ncbi Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis
    P Pantelidis
    Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, Imperial College of Science, Royal Brompton Campus, 1B Manresa Road, London SW3 6LR, United Kingdom
    Am J Respir Crit Care Med 163:1432-6. 2001
  8. pmc Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines
    L Buonaguro
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 66:7159-67. 1992
  9. ncbi HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line
    K J Sastry
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    J Biol Chem 265:20091-3. 1990
  10. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995

Research Grants

  1. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
  2. Lymphotoxin alpha Beta and LIGHT cytokine systems
    Carl F Ware; Fiscal Year: 2012
  3. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    Nancy H Ruddle; Fiscal Year: 2010
  4. Jun Li Luo; Fiscal Year: 2015
  5. LYMPHOTOXIN ALPHA IN SYSTEMIC IMMUNE RESPONSE
    Yang Xin Fu; Fiscal Year: 2001
  6. ASTHMA, ALLERGIC AND IMMUNOLOGIC DISEASES COOP RES CTR
    David Chaplin; Fiscal Year: 2000
  7. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
  8. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    NANCY RUDDLE; Fiscal Year: 2006
  9. DEVELOPMENT AND FUNCTION OF LYMPHOID TISSUES
    Yang Xin Fu; Fiscal Year: 2003
  10. LIGHT- A NEW THERAPEUTIC FOR HERPESVIRUS INFECTIONS
    Theresa Banks; Fiscal Year: 2000

Patents

  1. Polypeptides, their preparation and their use

Detail Information

Publications260 found, 100 shown here

  1. ncbi Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation
    D W Banner
    F Hoffmann La Roche Limited, Pharmaceutical Research New Technologies, Basel, Switzerland
    Cell 73:431-45. 1993
    ..of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined at 2.85 A resolution...
  2. ncbi Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy
    M Nishimura
    Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan
    Hum Immunol 61:1262-9. 2000
    ....
  3. ncbi Role of IL-6, TNF-A and LT-A variants in the modulation of the clinical expression of plaque-induced gingivitis
    Chiara Scapoli
    Department of Biology and Evolution, and Research Center for the Study of Periodontal Diseases, University of Ferrara, Via Luigi Borsari 46, Ferrara, Italy
    J Clin Periodontol 34:1031-8. 2007
    ..study was to assess the association of interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-A) and lymphotoxin alpha (LT-A) gene polymorphisms with the clinical parameters of gingivitis in a large experimental gingivitis ..
  4. doi Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components
    Catherine M Phillips
    Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Clin Endocrinol Metab 95:1386-94. 2010
    ..Cytokine polymorphisms and dietary fat composition may influence the risk of the metabolic syndrome (MetS)...
  5. ncbi Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes
    P Selvaraj
    Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, 600 031, India
    Tuberculosis (Edinb) 81:335-41. 2001
    ..A study of tumour necrosis factor alpha and beta (TNFalpha and beta) gene polymorphism and haplotype analysis with HLA in pulmonary tuberculosis...
  6. doi Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:141-50. 2009
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex...
  7. ncbi Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis
    P Pantelidis
    Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, Imperial College of Science, Royal Brompton Campus, 1B Manresa Road, London SW3 6LR, United Kingdom
    Am J Respir Crit Care Med 163:1432-6. 2001
    ..These findings, if independently confirmed, will be the first to suggest that disease progression in IPF may be linked to a particular genetic marker or to functional polymorphisms in other genes near that marker...
  8. pmc Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines
    L Buonaguro
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 66:7159-67. 1992
    ....
  9. ncbi HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line
    K J Sastry
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    J Biol Chem 265:20091-3. 1990
    ....
  10. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  11. pmc The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure
    L Buonaguro
    Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Virol 68:2677-82. 1994
    ..of human immunodeficiency virus type 1 (HIV-1) transactivates tumor necrosis factor alpha and beta (TNF alpha and TNF beta) gene expression in HIV-1-infected and in tat-transfected T-lymphocytic and monocytic cell lines...
  12. ncbi Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts
    U Utans
    Harvard School of Public Health, Department of Pathology, Deaconess Hospital, Boston, Massachussets, USA
    Transplantation 61:1387-92. 1996
    ..The parallels between rat and human AIF-1 expression suggest that AIF-1 may have a common effect on the function of activated macrophages in cardiac allografts...
  13. ncbi Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    R Sacca
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 160:485-91. 1998
    Lymphotoxin (LT, LT alpha, TNF beta) is a member of the immediate TNF family that also includes TNF-alpha and lymphotoxin-beta (LT beta)...
  14. ncbi Gene polymorphisms in the TNF locus and the risk of myocardial infarction
    J C Padovani
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Thromb Res 100:263-9. 2000
    ..8-113). Although significant interactive effects could not be detected, the findings suggest that interaction of polymorphisms in the TNF locus with major risk factors for CAD may exist, and should be explored in larger studies...
  15. ncbi Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand
    Ganwei Lu
    University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
    J Immunol 168:1831-9. 2002
    ..Overall, our data demonstrate that DCs are fully equipped for an efficient direct apoptotic killing of cancer cells and suggest that this mechanism may play a critical role in both afferent and efferent anti-tumor immunity...
  16. ncbi TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
    Masataka Nishimura
    Department of the Clinical Neuroscience, Tokushima University Hospital, Japan
    Hum Immunol 64:302-9. 2003
    ..These results suggest that the TNFR1 gene region might be a susceptible locus to type 1 diabetes in Japanese...
  17. ncbi TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction
    Jae Young Um
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Dongdaemun Gu, Seoul 130 701, South Korea
    J Mol Neurosci 21:167-71. 2003
    ..These results show that the TNF-alpha -308 and TNF-beta +252 locus plays an important role in the etiopathogenesis of CI...
  18. ncbi No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease
    M A Garcia-Gonzalez
    Unidad Mixta de Investigación and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Int J Immunogenet 32:299-306. 2005
    ..possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer...
  19. ncbi R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission
    Hela Saidi
    Unité INSERM U743 Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, Cedex 06, France
    Virology 358:55-68. 2007
    ..This study suggests that R5 and X4 viruses can differentially use epithelial cells to ensure their own spread...
  20. pmc Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 67:999-1004. 2006
    Tumor necrosis factor (TNF) and lymphotoxin alpha (LT-alpha) are immunomodulators that have been hypothesized to contribute to susceptibility to type 1 diabetes (T1D)...
  21. ncbi Association of human leukocyte antigen ancestral haplotype 8.1 with adverse outcome of non-Hodgkin's lymphoma
    Jacek Nowak
    Institute of Haematology and Blood Transfusion, Warsaw, Poland
    Genes Chromosomes Cancer 46:500-7. 2007
    ..1 ancestral haplotype (AH) and their relation to the clinical course of NHL. HLA class I, II, TNF-308, and lymphotoxin alpha (LTA+252) alleles were analyzed in 154 newly diagnosed NHL patients...
  22. ncbi Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis
    Anne Havemose-Poulsen
    Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 78:475-92. 2007
    ..An important question to address is how interleukin (IL)-1 polymorphisms affect the cytokine profiles of patients with such diseases...
  23. pmc Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells
    Lisa A Madge
    Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, University of Pennsylvania School of Veterinary Medicine, and The Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 180:3467-77. 2008
    ..Our findings therefore demonstrate that LTbetaR ligation regulates gene expression in endothelial cells via both NF-kappaB pathways and we identify CXCL12 as a bona fide noncanonical NF-kappaB-regulated gene in these cells...
  24. pmc Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia
    Vesna Boraska
    Department of Medical Biology, Medical School, University of Split, Split, Croatia
    Hum Immunol 70:195-9. 2009
    Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) are cytokines with a wide range of inflammatory and immunomodulatory activities...
  25. ncbi Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 32:650-4. 2002
    ..significant associations between myocardial infarction and a single 50 kb halpotype comprised of five SNPs in LTA (encoding lymphotoxin-alpha), NFKBIL1 (encoding nuclear factor of kappa light polypeptide gene enhancer in B cells, ..
  26. ncbi TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population
    L Bouqbis
    Laboratory of Cellular and Molecular Biology, University Ibnou Zohr, Agadir, Morocco
    Tissue Antigens 61:72-9. 2003
    ..At least two polymorphisms seem to have functional relevance in the respective genes: TNFA-307 and TNFB+252...
  27. ncbi Novel polymorphisms and the definition of promoter 'alleles' of the tumor necrosis factor and lymphotoxin alpha loci: inclusion in HLA haplotypes
    P E Posch
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
    Genes Immun 4:547-58. 2003
    Tumor necrosis factor (TNF) and lymphotoxin alpha (LTA) influence a variety of cellular responses and play a complex role in the immune response...
  28. ncbi The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension
    J Balding
    Thrombosis and Haemostasis Laboratory, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Ir J Med Sci 173:200-3. 2004
    ..Recent data suggest that inflammatory reactions are involved in the pathogenesis of cerebral ischaemia...
  29. doi Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma
    Eleftherios Vairaktaris
    Department of Maxillofacial Surgery, University of Athens Medical School, Attikon Hospital, Rimini 1, 12462, Athens, Greece
    J Cancer Res Clin Oncol 134:821-32. 2008
    ..The present retrospective case-control study examines possible interactions between seven cytokine genotype polymorphisms and their combinatory effect in predicting the occurrence of OSCC in Caucasians...
  30. pmc Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production
    G Messer
    Institute of Immunology, Ludwig Maximilians University, Munich 2, Federal Republic of Germany
    J Exp Med 173:209-19. 1991
    ..On days 2-4 after stimulation with mitogen, the TNFB*1 allele corresponding to a 5.3-kb NcoI fragment presented with a significantly higher TNF-beta response...
  31. pmc Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization
    G E Nedwin
    Nucleic Acids Res 13:6361-73. 1985
    ..In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent)...
  32. ncbi Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes
    J L Browning
    Department of Immunology, Biogen, Cambridge, MA 02142, USA
    J Immunol 159:3288-98. 1997
    The lymphotoxin-alpha beta complex (LT alpha beta) is found on the surface of activated lymphocytes and binds to a specific receptor called the LT beta receptor (LT beta R)...
  33. ncbi TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients
    A Lanas
    Department of Gastroenterology, Hospital Clinico Universitario, Zaragoza, Spain
    Genes Immun 2:415-21. 2001
    ..Polymorphisms in the genes encoding tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) have been shown to contribute to the severity of infectious disease...
  34. ncbi Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Genet 36:394-9. 2004
    Genetic variation at the human LTA locus, encoding lymphotoxin-alpha, is associated with susceptibility to myocardial infarction, asthma and other diseases...
  35. ncbi Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese
    Akira Yamada
    Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550 Nagoya, Japan
    J Mol Med (Berl) 82:477-83. 2004
    Vascular inflammation plays an important role in the development of myocardial infarction (MI). Lymphotoxin alpha (LTA) is a cytokine with multiple functions in regulation of the immune system and inflammatory reactions...
  36. ncbi The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome
    Y H Hamid
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 48:445-51. 2005
    Associations between variations in the lymphotoxin-alpha gene (LTA) and myocardial infarction, cerebral infarction and type 1 diabetes have previously been reported...
  37. ncbi Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis
    R Laxton
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Genes Immun 6:539-41. 2005
    ..association between susceptibility to myocardial infarction and the Thr26Asn polymorphism in the lymphotoxin-alpha (LTA) gene...
  38. pmc Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study
    Robert Clarke
    Clinical Trial Service Unit, Old Road Campus, Oxford, United Kingdom
    PLoS Genet 2:e107. 2006
    Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response...
  39. ncbi Relationship between polymorphisms 804C/A and 252A/G of lymphotoxin-alpha gene and -308G/A of tumor necrosis factor alpha gene and diabetic retinopathy in Japanese patients with type 2 diabetes mellitus
    Keiji Yoshioka
    Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Osaka 570 8540, Japan
    Metabolism 55:1406-10. 2006
    To clarify whether polymorphisms of the lymphotoxin-alpha (LTA) gene and tumor necrosis factor alpha (TNF-alpha) gene were related to diabetic retinopathy (DR), we performed a case-control study in 251 Japanese patients with type 2 ..
  40. ncbi Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations
    A Kimura
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Tissue Antigens 69:265-9. 2007
    To investigate the recently reported associations of polymorphisms in lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) with myocardial infarction (MI), we analyzed a single nucleotide polymorphism of LTA (LTA 252A>G in LTA intron 1) ..
  41. doi Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia
    Maria G Ennas
    Department of Cytomorphology, University of Cagliari, Cagliari, Italy
    Hematol Oncol 26:98-103. 2008
    ..gt; T, IL2-384T > G, IL6-174G > C, IL6-597G > A, IL10-1082A > G, IL10-3575T > A, TNF-308G > A, LTA- 91A > C, LTA 252A > G and CARD15 nt1007...
  42. doi Relevance of IL-1 and TNF gene polymorphisms on interleukin-1beta and tumor necrosis factor-alpha gastric mucosal production
    María A García-González
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Hum Immunol 70:935-45. 2009
    ..DNA was typed for the IL1B-511, IL1B+3954, variable number of tandem repeat (VNTR) IL1RN, TNFA-308, TNFA-238, LTA NcoI, and LTA Bsi gene polymorphisms by polymerase chain reaction, restriction fragment length polymorphism, and ..
  43. doi Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine
    Jayashri Ghosh
    Department of Genetics, Raebareli Road, Sanjay Gandhi Post Graduate Institute of Medical Sciences SGPGIMS, Lucknow 226014, UP, India
    J Neurol 257:898-904. 2010
    We aimed to look for the association of tumor necrosis factor (TNF) gene polymorphisms (TNFA 308G > A, and TNFB 252G > A) in genetic susceptibility to migraine...
  44. pmc Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
    Christine F Skibola
    237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 171:267-76. 2010
    ..7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain ..
  45. doi Lymphotoxin-alphabeta heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis
    Judy Young
    Department of Assay and Automation Technology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cytokine 51:78-86. 2010
    ..Therefore, soluble LTalphabeta in synovial fluid is associated with a proinflammatory cytokine milieu that contributes to synovitis in RA...
  46. ncbi TNF-alpha and TNF-beta gene polymorphisms in Polish patients with sarcoidosis. Connection with the susceptibility and prognosis
    R Kieszko
    Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Poland
    Sarcoidosis Vasc Diffuse Lung Dis 27:131-7. 2010
    ..The analysis of -308G > A TNF-alpha gene (TNFA*1 and TNFA*2 alleles) and 252A > G TNF-beta gene polymorphisms (TNFB*1 and TNFB*2 alleles) were performed.
  47. doi Association between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis
    Huang Tiancha
    Intensive Care Unit, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
    Scand J Infect Dis 43:436-47. 2011
    We evaluated the association of lymphotoxin-α (LTA, also known as tumour necrosis factor-β) promoter +252 A/G polymorphism with sepsis.
  48. ncbi Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma
    Y Kobayashi
    J Biochem 100:727-33. 1986
    ..The results obtained strongly suggested that the intactness of the C terminal less than 10 residues is required for the LT activity...
  49. ncbi Duration of non-Insulin-dependent diabetes mellitus and the TNF-beta NcoI genotype as predictive factors in proliferative diabetic retinopathy
    K Kankova
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Ophthalmologica 215:294-8. 2001
    ..The TNF-beta2 allele could be regarded as a separate genetic risk factor that increases the relative incidence of PDR in patients with NIDDM...
  50. ncbi The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population
    L Izakovicova Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Clin Exp Allergy 31:1418-23. 2001
    ..These genes, inducible by interferon gamma, as well as lymphotoxin alpha (LT-alpha), are located in the HLA region...
  51. ncbi The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents
    Ying Chu Lin
    Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan
    Allergy 57:831-4. 2002
    ..TNFalpha-308G/A frequencies between Japanese and Caucasians in the UK have been found to be different. The roles of HLA-DRB1 and TNF genotypes are unknown in Taiwanese adolescents with IgE-mediated asthma (I-asthma)...
  52. ncbi Gene-gene synergistic effect on atopic asthma: tumour necrosis factor-alpha-308 and lymphotoxin-alpha-NcoI in Taiwan's children
    T N Wang
    School of Public Health, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Clin Exp Allergy 34:184-8. 2004
    ..Tumour necrosis factor (TNF) is a potent cytokine in the inflammation response of the airway, and the polymorphisms of TNF genes have been associated with asthma...
  53. ncbi Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo 108 8639, Japan
    Nature 429:72-5. 2004
    ..of the artery, implicating a number of inflammation-mediating molecules, such as the cytokine lymphotoxin-alpha (LTA). Functional variations in LTA are associated with susceptibility to MI...
  54. ncbi Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20852, USA
    Genes Immun 5:505-12. 2004
    ..Therefore, we created marker panels for IL1B, IL6 and TNF/LTA that included the known functional marker but also other markers evenly spaced and with sufficient density to ..
  55. ncbi TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population
    Seong Gene Lee
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Cytokine 28:75-82. 2004
    The tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA) are proinflammatory cytokines with immunoregulatory effects. TNF is also known to inhibit gastric acid secretion...
  56. ncbi Lymphotoxin-alpha polymorphism and the risk of cervical cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 218:63-8. 2005
    ..64, 95% CI = 0.40-1.02; and OR = 0.45, 95% CI = 0.21-0.95, respectively), especially of SCC (OR = 0.54, 95% CI = 0.32-0.91; and OR = 0.39, 95% CI = 0.16-0.92, respectively)...
  57. pmc Molecular genetics of coronary artery disease
    Qing Wang
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Curr Opin Cardiol 20:182-8. 2005
    ..Many advances have recently been made, however, and these are reviewed here...
  58. ncbi Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan
    O Migita
    Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Clin Exp Allergy 35:790-6. 2005
    The tumour necrosis factor (TNF) gene family, which includes TNF, LTA, and LTB, is located consecutively on human chromosome 6p21 region, which has been linked to asthma by several genome-wide screens...
  59. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
    ..The TNF-alpha (TNF) and lymphotoxin-alpha (LTA) genes belong to the TNF gene superfamily located within the human major histocompatibility complex on chromosome ..
  60. pmc MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus
    N J McHugh
    Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, Somerset BA1 1RL UK
    Ann Rheum Dis 65:488-94. 2006
    To conduct a case-control study to investigate whether there are independent tumour necrosis factor alpha (TNFalpha) or lymphotoxin alpha (LTalpha) haplotype associations with SLE or with any of the major serological subsets of SLE.
  61. ncbi Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes
    E Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Site, Old Road, Headington, Oxford OX3 7LJ, UK
    Diabetologia 48:2013-7. 2005
    ..Additionally, the coding non-synonymous variant T60N in the neighbouring LTA gene has been reported to be associated with type 2 diabetes...
  62. ncbi Tumour necrosis factor gene polymorphisms and childhood wheezing
    H Bilolikar
    Dept of Paediatric Respiratory Medicine, Royal BromptonHospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 26:637-46. 2005
    ..In conclusion, these findings may have implications for future early intervention studies by helping to identify infants at increased risk for wheezing and childhood asthma...
  63. ncbi Tumor necrosis factor and lymphotoxin alfa genetic polymorphisms and outcome in pediatric patients with non-Hodgkin's lymphoma: results from Berlin-Frankfurt-Münster Trial NHL-BFM 95
    Kathrin Seidemann
    Department of Pediatric Hematology and Oncology, Children s Hospital, Hannover Medical School, Hannover, Germany
    J Clin Oncol 23:8414-21. 2005
    ..To analyze the association of genetic variation within the tumor necrosis factor (TNF -308 [G-->A]) and lymphotoxin alfa (LT-a +252 [A-->G]) genes with outcome in non-Hodgkin's lymphoma of childhood and adolescence...
  64. ncbi Polymorphisms in tumor necrosis factor genes and susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high incidence region of North China
    Wei Guo
    Laboratory of Molecular Biology Hebei Cancer Institute, Hebei Medical University, Shijiazhuang 050011, China
    Chin Med J (Engl) 118:1870-8. 2005
    ..We investigated the possible association of the functional polymorphisms in the tumor necrosis factor (TNF) genes with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA)...
  65. ncbi Association between non-Hodgkin lymphoma and haplotypes in the TNF region
    Charlotte F Spink
    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Br J Haematol 133:293-300. 2006
    ..Prediction of disease risk was improved by the addition of loci to the haplotype, demonstrating the importance of considering the haplotype-specific context of the loci in genetic risk assessment...
  66. ncbi Association of TNF haplotypes with asthma, serum IgE levels, and correlation with serum TNF-alpha levels
    Shilpy Sharma
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India
    Am J Respir Cell Mol Biol 35:488-95. 2006
    Both biochemical and genetic evidence have implicated the genes for TNF-alpha (TNFA) and lymphotoxin-alpha (LTA) in atopic asthma...
  67. ncbi Inflammation-related gene polymorphisms and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:1126-31. 2006
    ..adenoma with 19 single nucleotide polymorphisms in a range of important proinflammatory (IL1B, IL6, IL8, TNF, and LTA) and anti-inflammatory (IL4, IL10, and IL13) cytokines and other inflammation-related genes (PTGS2 and PPARG) in a ..
  68. ncbi A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study
    Yongmei Liu
    Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Eur J Cardiovasc Prev Rehabil 13:655-7. 2006
    The lymphotoxin-alpha (LTA) gene has been implicated in the pathogenesis of atherosclerosis...
  69. ncbi Possible correlation between polymorphism in the tumor necrosis factor-beta gene and the clinicopathological features of bladder cancer in Japanese patients
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:971-6. 2006
    ..We investigated whether a polymorphism of the TNF gene is associated with a susceptibility to bladder cancer and its disease status...
  70. ncbi Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha
    Xin Liu
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Epidemiol 164:984-9. 2006
    ..2001 and 2004 and evaluated whether this association was modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC genotype results in higher LTA production)...
  71. ncbi Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
    Cancer Res 66:9771-80. 2006
    ..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets...
  72. ncbi Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease
    Folkert W Asselbergs
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U S A
    Clin Sci (Lond) 112:291-8. 2007
    The pro-inflammatory cytokine LTA (lymphotoxin-alpha) has multiple functions in regulating the immune system and may contribute to inflammatory processes leading to CHD (coronary heart disease)...
  73. ncbi Lymphotoxin-alpha polymorphisms and the risk of endometrial cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Gynecology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gynecol Oncol 104:586-90. 2007
    ..To test the association of endometrial cancer with the lymphotoxin-alpha (LTalpha) C804A and A252G polymorphisms, a hospital-based incident case-control study was performed in Japanese subjects...
  74. ncbi Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Hum Genet 121:483-90. 2007
    ..rs361525, and rs1800610) to capture most of the genetic variation in TNF in addition to SNPs in lymphotoxin-alpha (LTA), a pro-inflammatory cytokine in linkage disequilibrium with the TNF promoter region...
  75. ncbi A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 8009, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:77-83. 2007
    ..07; seminoma, P 0.04; nonseminoma, P 0.11). We also observed excess frequencies among TGCT cases versus controls of LTA 252G (P(trend) = 0.08) and of the TNF variants -1042C (P(trend) = 0.06), -1036T (P(trend) = 0...
  76. ncbi Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample
    Anthony W Ryan
    Atherosclerosis 197:465-6. 2008
  77. ncbi Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations
    Kamil Sedlacek
    Klinik und Poliklinik fur Innere Medizin II, Universitatsklinikum Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    J Mol Med (Berl) 85:997-1004. 2007
    ..provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population...
  78. ncbi Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans
    Werner Koch
    Deutsches Herzzentrum Munchen, 80636 Munich, Germany
    Hum Mol Genet 16:1821-7. 2007
    Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13...
  79. ncbi Differential expression of new LTA splice variants upon lymphocyte activation
    Anna S Smirnova
    Immunogenetics Division, Pediatrics Department, Universidade Federal de Sao Paulo UNIFESP EPM, R Loefgreen 1235, 04040 031 São Paulo, SP, Brazil
    Mol Immunol 45:295-300. 2008
    b>Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses...
  80. pmc Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)-alpha levels in Asian Indians
    S Sharma
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Exp Immunol 151:251-9. 2008
    ..potentially functional promoter polymorphisms in the TNFA gene and a LTA_NcoI polymorphism (+252 position) of the LTA gene were genotyped in a clinically well-defined cohort of North-Indian patients with sarcoidosis (n = 96) and ..
  81. doi Lymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritis
    V F Panoulas
    Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
    Ann Rheum Dis 67:1550-6. 2008
    ....
  82. doi Polymorphisms in angiogenesis-related genes and prostate cancer
    Eric J Jacobs
    Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:972-7. 2008
    ..Potentially functional single nucleotide polymorphisms (SNP) in genes important in prostate angiogenesis (VEGF, HIF1A, and NOS3) have previously been associated with risk or severity of prostate cancer...
  83. doi Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia
    Mathieu Barbier
    Aix Marseille Universite, IFR 48, Faculte de Pharmacie, Laboratoire de Pharmacogénétique des Maladies Parasitaires EA 864, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Microbes Infect 10:673-9. 2008
    ..TNF polymorphisms have been associated with severe malaria, mild malaria, and parasitemia. Lymphotoxin-alpha gene (LTA) that belongs to the TNF family is one such candidate gene...
  84. pmc Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
    Kako Takei
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101 0062, Japan
    BMC Cancer 8:235. 2008
    Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer.
  85. doi Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample
    Carlo Asuni
    Headache Centre Franco Tocco, Section of Clinical Pharmacology, Dept of Neurosciences BB Brodie, University of Cagliari, PO San Giovanni di Dio, Via Ospedale 46, 09124 Cagliari, Italy
    J Neurol 256:194-7. 2009
    ....
  86. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe ..
  87. doi Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP
    Yee Soo Chae
    Department of Oncology Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, 700 721, Korea
    Cancer Chemother Pharmacol 65:571-7. 2010
    ..Accordingly, the present study analyzed the impact of polymorphisms of apoptosis-related genes on outcome in DLBCL patient treated with R-CHOP...
  88. pmc Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans
    Louise M Randall
    Queensland Institute of Medical Research and Australian Centre for Vaccine Development, and The University of Queensland, School of Population Health, Herston, Queensland, Australia
    J Infect Dis 202:117-24. 2010
    ..Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis...
  89. ncbi Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in Han Chinese
    Yan Liu
    Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, PR China
    Tohoku J Exp Med 224:119-25. 2011
    Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, has been implicated in the pathogenesis of coronary atherosclerosis...
  90. pmc Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis
    Markus Schürks
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, 3rd f, Boston, MA 02215 1204, USA
    Cephalalgia 31:1381-404. 2011
    ..Data on the association between TNFα and TNFβ gene polymorphisms and migraine are conflicting...
  91. doi MAOA, MTHFR, and TNF-β genes polymorphisms and personality traits in the pathogenesis of migraine
    Masakazu Ishii
    Department of Pathophysiology, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Cell Biochem 363:357-66. 2012
    ..including monoamine oxidase A (MAOA) T941G, methylenetetrahydrofolate reductase (MTHFR) C677T, and tumor necrosis factor beta (TNF-β) G252Α, and the neuroticism and conscientiousness scores in NEO-FFI were selected as ..
  92. doi A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population
    Renquan Lu
    Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    Cancer Epidemiol 36:e380-6. 2012
    ....
  93. doi The +252A/G polymorphism in the lymphotoxin-α gene increases the risk of asthma: a meta-analysis
    Min Yang
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China
    Respirology 17:1229-36. 2012
    ..However, the findings have been inconclusive. The aim of this study was to investigate the association between the +252A/G polymorphism in the LT-α gene and the risk of asthma by performing a meta-analysis...
  94. ncbi The lymphotoxin-α 252A>G polymorphism and breast cancer: a meta-analysis
    Ping Zhou
    Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi, China
    Asian Pac J Cancer Prev 13:1949-52. 2012
    The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC).
  95. doi Investigation of lymphotoxin α genetic variants in migraine
    Lotta E Oikari
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Building G05, Griffith University QLD 4222, Australia
    Gene 512:527-31. 2013
    ..Lymphotoxin α (LTA) is a cytokine secreted by lymphocytes and is a member of the tumour necrosis factor (TNF) family...
  96. doi Genetic variation in cytokine-related genes and migraine susceptibility
    Shani Stuart
    Genomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia
    Twin Res Hum Genet 16:1079-86. 2013
    ..The tumor necrosis factor (TNF) gene cluster, made up of TNFα, lymphotoxin α (LTA), and lymphotoxin β (LTB), has been implicated to influence the intensity and duration of local inflammation...
  97. ncbi The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution
    M J Eck
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
    J Biol Chem 267:2119-22. 1992
    ....
  98. ncbi Tumor necrosis factor gene polymorphism in migraine
    Simonetta Trabace
    Section of Medical Genetics, Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Headache 42:341-5. 2002
    ..To better define the involvement of human leukocyte antigen region (HLA) genes in migraine via an association study of the tumor necrosis factor (TNF) genes, located in the HLA class III region, with migraine with and without aura...
  99. ncbi Association of tumor necrosis factor polymorphisms with asthma and serum total IgE
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics Inc, Chongro Gu, Seoul, Korea
    Hum Mol Genet 13:397-403. 2004
    Tumor necrosis factors (TNF; TNFA and TNFB) are major pro-inflammatory cytokines that are thought to be important in the pathogenesis of asthma...
  100. ncbi LTA 252G allele containing haplotype block is associated with high serum C-reactive protein levels
    Gen Suzuki
    Department of Clinical Studies, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Atherosclerosis 176:91-4. 2004
    ..We examined the association between gene polymorphism of the LT-alpha coding gene, LTA A252G, and CRP based on a case-control study...

Research Grants73

  1. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..pathways include interleukins (IL), nuclear factor kappa B (NF-:B), tumor necrosis factor alpha (TNF-1) and lymphotoxin alpha (LTA)...
  2. Lymphotoxin alpha Beta and LIGHT cytokine systems
    Carl F Ware; Fiscal Year: 2012
    ..Moreover, the HVEM-BTLA system counter acts the closely related LTa(3-LT|3R system, which together regulates the homeostasis and expansion of specific subsets of dendritic cells in ..
  3. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    Nancy H Ruddle; Fiscal Year: 2010
    ..Directed over expression of lymphotoxin (LT) (either LTa or LTab) results in ectopic lymphoid aggregates with the characteristics of lymphoid organs...
  4. Jun Li Luo; Fiscal Year: 2015
    ..that one of the critical participants in this inflammatory response is tumor infiltrating B cells, which produce LTa:[unreadable] heterotrimers that stimulate LT[unreadable]R on PCa cells to induce IKKa nuclear translocation and ..
  5. LYMPHOTOXIN ALPHA IN SYSTEMIC IMMUNE RESPONSE
    Yang Xin Fu; Fiscal Year: 2001
    ..The candidate states that the functions of lymphotoxin alpha (LT-alpha) need to be reevaluated in light of the discovery of a receptor for the heteromer of LT-alpha and ..
  6. ASTHMA, ALLERGIC AND IMMUNOLOGIC DISEASES COOP RES CTR
    David Chaplin; Fiscal Year: 2000
    ..responses in the epidermis and the role of the proinflammatory cytokines IL-1-beta (IL-1b) and lymphotoxin-alpha (LTa) as mediators of sensitization...
  7. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
    ..We will also test whether expression of the ligands of LT[unreadable]R, LTa[unreadable] or LIGHT, on spleen cells and LT[unreadable]R on islet [unreadable]-cells is critical for stimulating [..
  8. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    NANCY RUDDLE; Fiscal Year: 2006
    ..Simultaneous expression of LTa and LTb results in the formation of ectopic lymphoid aggregates with the characteristics of lymphoid organs arising ..
  9. DEVELOPMENT AND FUNCTION OF LYMPHOID TISSUES
    Yang Xin Fu; Fiscal Year: 2003
    ....
  10. LIGHT- A NEW THERAPEUTIC FOR HERPESVIRUS INFECTIONS
    Theresa Banks; Fiscal Year: 2000
    ..Preliminary experiments have demonstrated that LIGHT is structurally related to lymphotoxin alpha and beta and tumor necrosis factor (TNF) and that picomolar amounts of LIGHT can inhibit the spread of ..
  11. DEVELOPMENT OF NK CELLS BY LYMPHOTOXIN
    Yang Xin Fu; Fiscal Year: 2000
    ..This study will also help them to elucidate the molecular mechanisms involved in NK-mediated diseases and to design new approaches for manipulation of their immune responses and management of those patients in the future. ..
  12. Vascular Disease and Inflammation in Mice
    Renee Leboeuf; Fiscal Year: 2009
    ..long range goal is to understand how tumor necrosis factor alpha (TNF) receptors and ligands, TNF and lymphotoxin (LTa) contribute to atherosclerosis...
  13. LYMPHOTOXIN: REGULATION AND BIOLOGICAL SIGNIFICANCE
    NANCY RUDDLE; Fiscal Year: 2006
    ..monitoring expression of a reporter gene (Beta galactosidase or yellow fluorescent protein) knocked into the LTa locus; analyzing the role of Ikaros, a chromatin remodeling protein, in regulation of LTa and LTBeta with Ikaros ..
  14. Activation of Macrophages by Lipoteichoic Acid
    David L Hasty; Fiscal Year: 2010
    ..One bacterial component long thought to affect the host inflammatory response is lipoteichoic acid (LTA), a surface component expressed by virtually all G+ bacteria and released into the surrounding environment during ..
  15. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..As no such LTA currently exists, LTAs will be synthesized and tested for their ability to localize in lysosomes and prevent ..
  16. CELLULAR MECHANISMS OF DRUG REACTIONS IN SCHIZOPHRENIA
    Edmond Yunis; Fiscal Year: 1999
    ..suggest that common variants of non-HLA genes (TNF DNA constellations; a,b,c,d,e microsatellites, n intron of TNFB and -308 of promoter region of TNFa) (given in the gene order b,a,n,c, -308, e,d) within the major ..
  17. Peptide mimics of BMP7 for treatment of renal fibrosis and diabetic nephropathy
    William J Dower; Fiscal Year: 2012
    ..address this need by developing novel peptide mimics of bone morphogenic protein 7 (BMP7) - a key cytokine in the TNFb superfamily that has the ability to halt, and even reverse, the progression of renal fibrosis, which is the primary ..
  18. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    ..This proposal has three specific aims: (1) Create and characterize point mutants of LTA that have partial or complete loss of the ability to bind and be activated by human Arf proteins...
  19. Beth A Reboussin; Fiscal Year: 2016
    ..Our goals will be accomplished using two innovative statistical techniques~ latent transition analysis (LTA) for studying empirically-derived stages of marijuana use and alternating logistic regressions (ALR) for estimating ..
  20. BIOSYNTHESIS OF BACTERIAL CELL WALL COMPONENTS
    Francis Neuhaus; Fiscal Year: 1991
    ..2) Penicillin also causes the enhanced secretion of water-soluble PG, lipids, LTA and proteins. It is our aim to establish the mechanisms of the penicillin-induced release of these compounds...
  21. LBP/CD14 interactions with bacterial components
    Richard Darveau; Fiscal Year: 2005
    ..These key innate host defense proteins respond to both LTA from gram positive organisms and LPS from gram negative bacteria...
  22. INTERACTION OF ORAL STREPTOCOCCI WITH ANIMAL TISSUES
    MURRAY STINSON; Fiscal Year: 2001
    ..and several species of oral streptococci produce a cationic histone-like protein (HlpA) and lipoteichoic acid (LTA) that bind, respectively, to heparan sulfate proteoglycans in basement membranes and to vascular endothelial cells ..
  23. RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN
    Paul Davenport; Fiscal Year: 2004
    ..This project has demonstrated that children with a history of life threatening asthma attacks (LTA) have a significantly decreased perceptual sensitivity to increased extrinsic loads and an increased threshold for ..
  24. Predictors of Treatment Response in Early Aggressive RA
    S Bridges; Fiscal Year: 2007
    ..MTX and etanercept indicates that response is predicted by haplotypes comprising HLA DRB1 alleles and TNF/LTA single nucleotide polymorphisms (SNPs)...
  25. IRAK Family Function in Bacterial Infection
    James Thomas; Fiscal Year: 2001
    ..and macrophages exhibit impaired responses to lipopolysaccharide (LPS), peptidoglycan (PGN), and lipotechoic acid (LTA), and CpG DNA, bacterial molecules that activate the afferent arm of innate immunity through TLR4 and TLR2...
  26. TOLL-LIKE RECEPTOR REGULATION IN THE MYOCARDIUM
    Marita Thompson; Fiscal Year: 2004
    ..The systemic LPS response is modulated by LPS, repeated LPS administration, lipoteichoic acid (LTA) and burn serum...
  27. Receptors Involved in Microglial Responses to S. aureus
    Tammy Kielian; Fiscal Year: 2005
    ..activation in response to the gram-positive cell wall products peptidoglycan (PGN) and lipoteichoic acid (LTA)...
  28. MECHANISMS OF AIRWAY HYPERREACTIVITY
    William Gerthoffer; Fiscal Year: 2004
    ..response of cultured human bronchial smooth (hBSM) muscle cells stimulated with a defined cytokine mixture (IL-1b, TNFb, IFNy) or bronchioalveolar lavage (BAL) fluid from asthmatic patients...
  29. IRAK Family Function in Bacterial Infection
    James Thomas; Fiscal Year: 2006
    ..and macrophages exhibit impaired responses to lipopolysachharide (LPS), peptidoglycan (PGN), lipotechoic acid (LTA), and CpG DNA, bacterial molecules that activate the afferent arm of innate immunity through TLR4 and TLR2...
  30. Classes and Stages of Adolescent Alcohol Involvement
    John Donovan; Fiscal Year: 2009
    ..Aim 5: The two 4-wave PBT data sets will be further analyzed using Latent Transition Analysis (LTA) to investigate the antecedent risk factors for transitions from one stage to another...
  31. SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA
    Anthony Mansell; Fiscal Year: 2004
    ..three established indices of respiratory perception to test for blunted perception on compromised lung function in LTA adolescents, (2) to identify psychological factors that influence respiratory perception in adolescents and (3) to ..
  32. Portable fiber laser for glaucoma surgery
    KURT LINDEN; Fiscal Year: 2003
    ..Sclerectomy and laser trabecular ablation (LTA) procedures will be carried out with the fiber laser...
  33. SMALL SAMPLE METHODOLOGY FOR DRUG USE RESEARCH
    Tammy Root; Fiscal Year: 2007
    ..For example, latent transition analysis (LTA) has been used extensively to model the development of substance use (Collins & Wulgalter, 1992)...
  34. PROTECTIVE CAPACITY OF HIV EARLY PROTEIN SPECIFIC CTL
    Albert Osterhaus; Fiscal Year: 2001
    ..Furthermore, we have recently shown that shortly after primary infection, long term asymptomatic individuals (LTA) develop HIV-1 early protein (Rev and Tat) specific CTL responses whereas fast progressors fail to do so...
  35. Candidate Genes and CMV in Schizophrenia Risk
    Brian Shirts; Fiscal Year: 2007
    ..CMV) as a risk factor for schizophrenia in conjunction with polymorphisms in six positional candidate genes: TNF, LTA, MICB, IL-1beta, IL1RN, and IL-10...
  36. ROLE OF TUMOR NECROSIS FACTOR-ALPHA IN DEVELOPMENT
    JOAN HUNT; Fiscal Year: 2000
    ..the functions of trophoblast cell TNFa that include use of knockout (KO) mice carrying deletions of the TNFa/LTa and TNF receptor (TNF-R) genes, and generation of mouse trophoblastic cell lines from these as well as normal mice...
  37. Genetic Polymorphisms in Myeloma
    Brian Van Ness; Fiscal Year: 2003
    ..resistance 1); DNA repair (XRCCC1, ERCC2); and, myeloma related growth factors (lL-6, IL-1b, IL-1RA, IL-10, TNa, Lta, TGFb)...
  38. MOLECULAR MECHANISMS OF REGULATION IN BACTERIA
    Werner Maas; Fiscal Year: 1999
    ..For the regulation of LT synthesis we plan to investigate the temperature dependence by carrying out in vivo footprinting experiments in the wild type and mutants deleted for H-NS binding sites in the LTA gene.
  39. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  40. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  41. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..
  42. BASIC MECHANISMS IN LUNG DISEASE
    Janet Yother; Fiscal Year: 2007
    ..Based on our program's strong record of productivity and its importance in these endeavors, we seek to continue our role in training young investigators for productive careers in pulmonary research. ..
  43. Mechanisms of polysacchairde synthesis by S. pneumoniae
    JANET L YOTHER; Fiscal Year: 2010
    ..The relevance of these properties to the pathogenesis of S. pneumoniae will also be assessed, allowing us to better understand an essential virulence factor of this and many other bacteria. ..
  44. NEURODEGENERATIVE MECHANISMS IN ALZHEIMER'S DISEASE
    Piruz Nahreini; Fiscal Year: 2004
    ....
  45. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  46. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  47. MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  48. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  49. STRUCTURE OF THE HUMAN CHEMOKINE LYMPHOTACTIN
    BRIAN VOLKMAN; Fiscal Year: 2003
    ..abstract_text> ..
  50. Ethanol-fed, CpG-treated mice: Listeria susceptibility
    Nancy Ray; Fiscal Year: 2005
    ..These studies could lead to treatments for protecting alcoholic patients from intracellular bacterial infections such as those caused by L. monocytogenes or Mycobacterium tuberculosis (TB). ..
  51. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..that include genes encoding inflammatory and regulatory cytokines (IL-1A IL-1B IL-1RN TNFalpha), Th1/Th2 cytokines (LTA, INFgamma IL-4, IL-4RA IL-6 iL-JO, IL-13), innate immunity (MPO, ICAM-1) and chemokines (IL-8, SDF-1, CCR2, CCR5); ..
  52. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  53. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  54. ENZYMATIC ACTIVATION OF LIPOPHILIC SIGNALING MOLECULES
    Marcia Newcomer; Fiscal Year: 2004
    ..The expression of this activity as a fusion protein with lipoxygenase is predicted to facilitate the transfer of the reaction intermediate between catalytic sites. ..
  55. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..The use of FnBP as an anti-adhesin presents a novel therapeutic tool for the prevention of S. aureus infections. ..
  56. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  57. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  58. Mechanisms of Change in Alcohol Treatment for Dually Diagnosed Youth
    Tammy Chung; Fiscal Year: 2008
    ..Results have important implications for improving the design and delivery of treatment provided to dually diagnosed adolescents. [unreadable] [unreadable] [unreadable]..
  59. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  60. Identification of Measles Class II-Restricted Peptides
    INNA OVSYANNIKOVA; Fiscal Year: 2003
    ..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
  61. Conformational duality in the human chemokine Ltn/XCL1
    BRIAN VOLKMAN; Fiscal Year: 2009
    ..These structural and biochemical studies are designed to open new avenues for in vivo modulation of lymphocyte trafficking directed by Lymphotactin. ..
  62. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  63. GENETIC EPIDEMIOLOGY OF RSV BRONCHIOLITIS AND ASTHMA
    Adrienne Randolph; Fiscal Year: 2004
    ..Identifying the genes associated with the onset of childhood asthma could lead to targeted interventions aimed at prevention and treatment of this disorder that is increasing at a rate of 5 percent per year. ..
  64. Lysine decarboxylase in periodontitis patients
    Martin Levine; Fiscal Year: 2004
    ..abstract_text> ..
  65. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  67. CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANS
    FRANK AUSTEN; Fiscal Year: 2007
    ..abstract_text> ..
  68. Chlamydia trachomatis and Cervical Cancer
    MARGARET MADELEINE; Fiscal Year: 2003
    ..trachomatis may become a higher public health priority. Furthermore, our results would help determine whether further follow up of the C. trachomatis and cervical cancer association is warranted in a more expensive, prospective setting. ..
  69. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  70. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  71. Studies of CRH and Alcohol Effects
    Tamara Phillips; Fiscal Year: 2005
    ..This research represents an important step toward the validation of CRH receptors as targets for future medications development in the treatment and prevention of alcoholism. ..
  72. Intracellular Signaling Triggered by Tall-1/BCMA
    Hong Bing Shu; Fiscal Year: 2005
    ..The genes and their protein products identified in this study may be used as molecular targets for drug development against certain immune-deficient and autoimmune diseases. ..

Patents1

  1. Polypeptides, their preparation and their use
    Patent Number: EP0250000-A2; Date:1987-12-23