LSP1

Summary

Gene Symbol: LSP1
Description: lymphocyte-specific protein 1
Alias: WP34, pp52, lymphocyte-specific protein 1, 47 kDa actin binding protein, 52 kDa phosphoprotein, F-actin binding and cytoskeleton associated protein, leufactin (leukocyte F-actin binding protein), leukocyte-specific protein 1, lymphocyte-specific antigen WP34
Species: human

Top Publications

  1. ncbi The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines
    Y Li
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham 35233, USA
    J Immunol 155:3563-9. 1995
  2. pmc Lymphocyte-specific protein 1: a specific marker of human leucocytes
    K Pulford
    Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Biochemistry and Cellular Science, John Radcliffe Hospital, Oxford, UK
    Immunology 96:262-71. 1999
  3. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
  4. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
  5. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
  6. pmc HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
    Appakkudal R Anand
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Blood 114:3588-600. 2009
  7. pmc Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane
    D P Klein
    Department of Immunology, University of Toronto, Ontario, Canada
    Mol Cell Biol 9:3043-8. 1989
  8. ncbi Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains
    Q Zhang
    Department of Cell Biology, School of Medicine, University of Alabama, Birmingham, AL 35295, USA
    J Immunol 165:2052-8. 2000
  9. ncbi A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids
    Michael J Wong
    Toronto Western Research Institute, Cell and Molecular Biology Division and the Department of Immunology, University of Toronto, Toronto, ON, Canada M5T 2S8
    Biochim Biophys Acta 1642:17-24. 2003
  10. ncbi Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation
    Susanna Prösch
    Institutes of Virology, University Hospital Charite, Humboldt University, Berlin, Germany
    Antivir Ther 8:555-67. 2003

Research Grants

Scientific Experts

Detail Information

Publications149 found, 100 shown here

  1. ncbi The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines
    Y Li
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham 35233, USA
    J Immunol 155:3563-9. 1995
    Lymphocyte-specific protein 1 (LSP1) was originally reported as a lymphocyte-specific actin-binding protein using murine LSP1 probes...
  2. pmc Lymphocyte-specific protein 1: a specific marker of human leucocytes
    K Pulford
    Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Biochemistry and Cellular Science, John Radcliffe Hospital, Oxford, UK
    Immunology 96:262-71. 1999
    While both murine and human homologues of the LSP1 gene (lymphocyte-specific gene 1) and its protein products have been identified, studies on human LSP1 have been limited...
  3. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0...
  4. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
    ..Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer...
  5. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk...
  6. pmc HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
    Appakkudal R Anand
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Blood 114:3588-600. 2009
    ..Taken together, our studies provide an insight into a novel gp120-mediated pathway that regulates DC chemotaxis and contributes to the dissemination of HIV-1 within an infected person...
  7. pmc Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane
    D P Klein
    Department of Immunology, University of Toronto, Ontario, Canada
    Mol Cell Biol 9:3043-8. 1989
    The gene for LSP1 is a lymphocyte-specific gene previously isolated by us using a subtractive hybridization technique...
  8. ncbi Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains
    Q Zhang
    Department of Cell Biology, School of Medicine, University of Alabama, Birmingham, AL 35295, USA
    J Immunol 165:2052-8. 2000
    Human lymphocyte-specific protein 1 (LSP1) is an F-actin binding protein, which has an acidic N-terminal half and a basic C-terminal half...
  9. ncbi A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids
    Michael J Wong
    Toronto Western Research Institute, Cell and Molecular Biology Division and the Department of Immunology, University of Toronto, Toronto, ON, Canada M5T 2S8
    Biochim Biophys Acta 1642:17-24. 2003
    The leukocyte specific protein 1 or LSP1 is a multi functional protein involved in such divers biological processes as the regulation of neutrophil motility, chemotaxis, adhesion and membrane immunoglobulin M (mIgM) mediated apoptosis of ..
  10. ncbi Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation
    Susanna Prösch
    Institutes of Virology, University Hospital Charite, Humboldt University, Berlin, Germany
    Antivir Ther 8:555-67. 2003
    ..Early and late protein synthesis as shown exemplary for the pp52 (DNA-binding protein) and p68 (structural protein) protein production and viral DNA synthesis were also inhibited...
  11. ncbi Eisosomes mark static sites of endocytosis
    Tobias C Walther
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600 16th Street, San Francisco, California 94143 2200, USA
    Nature 439:998-1003. 2006
    ..meaning into or portal, and 'soma', meaning body), are composed primarily of two cytoplasmic proteins, Pil1 and Lsp1. A plasma membrane protein, Sur7, localizes to eisosomes...
  12. ncbi The LSP1 gene is expressed in cultured normal and transformed mouse macrophages
    J Jongstra
    Arthritis Centre Research Unit, Toronto Hospital Research Institute, Ontario, Canada
    Mol Immunol 31:1125-31. 1994
    The mouse LSP1 protein is an F-actin binding protein initially isolated as a cDNA from the BALB/c pre-B cell line 220.2. Its expression pattern is highly restricted. Only lymphocytes and lymphoma cell lines were reported to express LSP1...
  13. ncbi Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis
    Chunjie Wang
    Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
    J Immunol 169:415-23. 2002
    Leukocyte-specific protein 1 (LSP1) is an intracellular filamentous-actin binding protein which modulates cell motility. The cellular process in which LSP1 functions to regulate motility is not yet identified...
  14. ncbi Improvement in postburn hypertrophic scar after treatment with IFN-alpha2b is associated with decreased fibrocytes
    Jianfei Wang
    Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, Canada
    J Interferon Cytokine Res 27:921-30. 2007
    ..staining, and confocal microscopy, we demonstrate here that the marker protein leukocyte-specific protein 1 (LSP1) is stably expressed by fibrocytes for at least 2 months, whereas other potential fibrocyte markers, such as CD34 ..
  15. ncbi Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate
    K Kuwahara
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    J Immunol 152:2742-52. 1994
    ..These molecules would provide the informations of the down-stream molecules in the cascade reactions of the IgR-mediated signal transduction...
  16. pmc Genome-wide association study identifies five new breast cancer susceptibility loci
    Clare Turnbull
    Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:504-7. 2010
    ..We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7...
  17. ncbi Expression of the prokaryotic gene for chloramphenicol acetyl transferase in Drosophila under the control of larval serum protein 1 gene promoters
    J A Davies
    J Mol Biol 189:13-24. 1986
    ..chloramphenicol acetyl transferase (CAT) to the promoter region of the Drosophila genes for larval serum protein 1 (LSP1). These regions consist of 1.65 X 10(3) and 2...
  18. pmc Duplicative and conservative transpositions of larval serum protein 1 genes in the genus Drosophila
    Josefa González
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Genetics 168:253-64. 2004
    ..In the Drosophila melanogaster genome, three Larval serum protein 1 (Lsp1) genes (alpha, beta and gamma) are present and each of them is located on a different chromosome, suggesting ..
  19. pmc Discovering biomarkers from gene expression data for predicting cancer subgroups using neural networks and relational fuzzy clustering
    Nikhil R Pal
    Electronics and Communication Sciences Unit, Indian Statistical Institute, India
    BMC Bioinformatics 8:5. 2007
    ..We use multilayer networks with online gene selection ability and relational fuzzy clustering to identify a small set of biomarkers for accurate classification of the training and blind test cases of a well studied data set...
  20. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  21. pmc Genetic susceptibility loci for breast cancer by estrogen receptor status
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 14:8000-9. 2008
    ..studies has led to the discovery of novel breast cancer susceptibility loci in genic (CASP8, FGFR2, TNRC9, MAP3K1, LSP1) and nongenic regions (8q24, 2q35, 5p12) of the genome, and to the finding of substantial heterogeneity by tumor ..
  22. pmc Breast cancer susceptibility: current knowledge and implications for genetic counselling
    Tim Ripperger
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 17:722-31. 2009
    ..cancer susceptibility polymorphisms within genes as well as in chromosomal loci with no known genes (FGFR2, TOX3, LSP1, MAP3K1, TGFB1, 2q35 and 8q)...
  23. doi Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 59:627-34. 2010
    ..Here, we describe the effects of LSP1-2111 ((2S)-2-amino-4-[hydroxy[hydroxy(4-hydroxy-3-methoxy-5-nitro-phenyl)methyl]phosphoryl]butanoic acid), a novel ..
  24. doi Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
    Yongdong Jiang
    Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Xiangfang District, Harbin, 150081, China
    Breast Cancer Res Treat 128:251-7. 2011
    ..417 (P = 2×10⁻⁴). However, no significant association was detected between SNPs from TNCR9, LSP1, MAP3K1, 2q35, and 8q24 and breast cancer...
  25. doi Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells
    Laurent Sabbagh
    Maisonneuve Rosemont Hospital Research Centre, Montreal, Quebec, Canada
    J Leukoc Biol 93:713-21. 2013
    ..With the use of a proteomics approach in primary T cells, we have identified LSP1 as a novel protein recruited to the 4-1BB signaling complex in a TRAF1-dependent manner...
  26. pmc Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors
    Stefan Nickels
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS Genet 9:e1003284. 2013
    ..All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction = 2...
  27. pmc Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia
    S Lani Park
    Affiliations of authors Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA SLP, FRS, CAH Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA MDF, JMK, Ay, yl, UP, CC, CK Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, UK MT Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI CPC, LRW, LL Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH YH, CIA Department of Epidemiology S AL, AB, Ken, GH and Carolina Center for Genome Sciences KEN, University of North Carolina, Chapel Hill, NC Molecular Physiology and Biophysics LD, DCC, Tel Aviv University
    J Natl Cancer Inst 106:dju061. 2014
    ..A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed...
  28. pmc Myogenic differential methylation: diverse associations with chromatin structure
    Sruti Chandra
    Center for Bioinformatics and Genomics, New Orleans, LA 70112, USA
    Biology (Basel) 3:426-51. 2014
    ..For LSP1, alternative promoter usage and active promoter-type chromatin were linked to highly specific myogenic or ..
  29. pmc Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
    Sara Lindstrom
    1 Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA 2 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Commun 5:5303. 2014
    ..We identify genome-wide significant (P<5 × 10(-8)) loci for dense area (AREG, ESR1, ZNF365, LSP1/TNNT3, IGF1, TMEM184B and SGSM3/MKL1), non-dense area (8p11.23) and percent density (PRDM6, 8p11.23 and TMEM184B)...
  30. pmc Correlation between LSP1 polymorphisms and the susceptibility to breast cancer
    Hai Chen
    Department of Galactophore, The General Hospital of Beijing Military Command Beijing, China
    Int J Clin Exp Pathol 8:5798-802. 2015
    The present study aimed at assessing the relationship between Leukocyte-specific protein 1 gene (LSP1) polymorphisms (rs569550 and rs592373) and the pathogenesis of breast cancer (BC).
  31. doi Disentangling metabolic pathways involved in copper resistance in Candida fukuyamaensis RCL-3 indigenous yeast
    Verónica Irazusta
    PROIMI CONICET, Tucuman, Argentina
    J Basic Microbiol 56:698-710. 2016
    ..were identified, namely nucleoporin pom152, elongation factor 2, copper chaperone Sod1 Ccs1, and eiosome component Lsp1. The proteomic analysis performed allowed the identification of different metabolic pathways and certain proteins ..
  32. pmc TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk
    Ying Chen
    Department of Radiology, Shengjing Hospital Affiliated to China Medical University, No 36, Sanhao ST, Heping District, Shenyang, Liaoning Province, 110004, China
    World J Surg Oncol 14:50. 2016
    ..factor receptor 2 (FGFR2) rs2981582, trinucleotide-repeat-containing 9 (TNRC9) rs3803662, rs12443621, and leukocyte-specific protein 1 (LSP1) rs3817198 polymorphisms with breast cancer and mammographic density in Han Chinese population.
  33. ncbi New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women
    Seyed Mohammad Poorhosseini
    Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran E mail
    Asian Pac J Cancer Prev 17:155-60. 2016
    ..The objective of this study was to examine the gene expression profiles of SIRT3, HRAS, LSP1, SCUBE2 and AP2A2 in Iranian women with BC...
  34. pmc Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells
    Jung Lin Wu
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan
    Nat Commun 7:12526. 2016
    ..phosphoproteins, temporal regulation of the O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 (Lsp1) is a key switch that triggers apoptosis in activated B cells...
  35. pmc The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a meta-analysis of twelve studies
    Jianzhou Tang
    Department of Biological and Environmental Engineering, Changsha University, Changsha 410003, Hunan, China
    Oncotarget 7:63960-63967. 2016
    The association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk has been widely investigated, but remains controversial...
  36. pmc Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation
    Anil Prasad
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Rep 7:40648. 2017
    ..We found that cocaine activates a DC-SIGN mediated 'signalosome' complex by enhancing its association with LARG and LSP1. Further, LARG was observed to participate in DC-SIGN mediated internalization of HIV-1 in DCs...
  37. ncbi Lymphocyte isoforms of mouse p50 LSP1, which are phosphorylated in mitogen-activated T cells, are formed through alternative splicing and phosphorylation
    N Matsumoto
    Department of Parasitology, University of Tokyo
    J Biochem 118:237-43. 1995
    ..lymphocyte form of p50 exhibits heterogeneity in the apparent molecular mass on SDS-PAGE, 50 and 52 kDa (pp50 and pp52), and each isoform exhibits heterogeneity in the isoelectric point, when examined by two-dimensional PAGE...
  38. ncbi LSP1 modulates leukocyte populations in resting and inflamed peritoneum
    J Jongstra-Bilen
    Toronto Western Research Institute, Cell and Molecular Biology Division and Department of Immunology, University of Toronto, Ontario, Canada
    Blood 96:1827-35. 2000
    Lymphocyte-specific protein 1, recently renamed leukocyte-specific protein 1 (LSP1), is an F-actin binding protein expressed in lymphocytes, macrophages, and neutrophils in mice and humans...
  39. ncbi Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease
    Teresa Marafioti
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Haematologica 89:957-64. 2004
    ..In this paper, we have evaluated the usefulness of the pan-leukocyte marker LSP1 and the transcription factor PU.1 for resolving such diagnostic problems.
  40. ncbi Phototactic activity in Chlamydomonas 'non-phototactic' mutants deficient in Ca2+-dependent control of flagellar dominance or in inner-arm dynein
    Noriko Okita
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0063, Japan
    J Cell Sci 118:529-37. 2005
    ..A newly isolated mutant, lsp1, that displays weak phototaxis was found to be defective in this Ca(2+)-dependent shift in flagellar dominance; in ..
  41. ncbi Leukocyte-specific protein 1 (LSP1): a regulator of leukocyte emigration in inflammation
    Jenny Jongstra-Bilen
    Cell and Molecular Biology Division, Toronto General Research Institute, University Health Network, Toronto Western Research Institute, University Health Network, Ontario, Canada
    Immunol Res 35:65-74. 2006
    b>LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells...
  42. ncbi Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia
    Enca Martin-Rendon
    Stem Cell Research Laboratory, National Blood Service, Oxford Centre, The John Radcliffe Hospital, Headington, OX3 9BQ, United Kingdom
    Stem Cells 25:1003-12. 2007
    ..Several of these genes, namely CDTSPL, CCL20, LSP1, NEDD9, TMEM45A, EDG-1, and EPHA3 were confirmed to be regulated by hypoxia using quantitative reverse ..
  43. ncbi Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes
    Jianfei Wang
    Wound Healing Research Group Division of Plastic and Reconstructive Surgery and Critical Care, Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    J Leukoc Biol 82:1554-63. 2007
    ..We previously established leukocyte-specific protein 1 (LSP1) as a marker for fibrocytes...
  44. doi Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism
    Corinne Beurrier
    Institut de Biologie du Developpement de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Marseille, France
    FASEB J 23:3619-28. 2009
    ..Here we characterize the functional action of a new orthosteric group III mGlu agonist, LSP1-2111, with a preferential affinity for mGlu4 receptor...
  45. pmc Eisosome organization in the filamentous ascomycete Aspergillus nidulans
    Ioannis Vangelatos
    Institute of Biology, National Center for Scientific Research, Demokritos, Athens, Greece
    Eukaryot Cell 9:1441-54. 2010
    ..They comprise two homologue proteins, Pil1 and Lsp1, which colocalize with the transmembrane protein Sur7. These proteins are universally conserved in the ascomycetes...
  46. doi Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo
    Björn Petri
    Immunology Research Group, Department of Physiology and Pharmacology, The Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Germany
    Blood 117:942-52. 2011
    ..Leukocyte-specific protein 1 (LSP1), an F-actin-binding protein recently shown to be in the endothelium, is critical for effective transmigration, ..
  47. pmc Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans
    Michelle D Leach
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 22:687-702. 2011
    ..g., Tub1, Cct7, Mlc1), secretion, and endocytosis (e.g., Lsp1, Sec24, Sec7). The output from this proteomic screen was entirely consistent with the phenotypes of C...
  48. pmc Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    Carl A Anderson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:246-52. 2011
    ..insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared ..
  49. pmc The eisosome core is composed of BAR domain proteins
    Agustina Olivera-Couto
    Institut Pasteur de Montevideo, Montevideo 11400, Uruguay
    Mol Biol Cell 22:2360-72. 2011
    ..We found that the core components of eisosomes, paralogue proteins Pil1 and Lsp1, are distant homologues of membrane-sculpting Bin/amphiphysin/Rvs (BAR) proteins...
  50. doi Eisosome-driven plasma membrane organization is mediated by BAR domains
    Natasza E Ziółkowska
    Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany
    Nat Struct Mol Biol 18:854-6. 2011
    ..Eisosomes are key complexes for yeast plasma membrane organization, containing primarily Pil1 and Lsp1. Here we show that both proteins consist mostly of a banana-shaped BAR domain common to membrane sculpting proteins,..
  51. pmc Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk
    Celine M Vachon
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:1156-66. 2012
    ..We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic density measures...
  52. doi Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor
    Anna Sławińska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 66:225-35. 2013
    Previous studies demonstrated that the Group III mGlu receptor-selective orthosteric agonist, LSP1-2111 produced anxiolytic- but not antidepressant-like effects upon peripheral administration...
  53. doi Different microvascular permeability responses elicited by the CXC chemokines MIP-2 and KC during leukocyte recruitment: role of LSP1
    Xi Lei
    Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Biochem Biophys Res Commun 423:484-9. 2012
    ..Leukocyte-specific protein 1 (LSP1), a Ca2+- and F-actin binding protein, is one of the major downstream substrates of p38 MAPK...
  54. pmc The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk
    Shaneda Warren Andersen
    University of Wisconsin Carbone Cancer Center, 610 Walnut St, WARF Room 307, Madison, WI 53726, USA
    Breast Cancer Res Treat 140:427-34. 2013
    ..associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer. Women in the score's highest quintile had 2...
  55. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  56. doi Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation
    Sonja I Gringhuis
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nat Commun 5:3898. 2014
    ..Crosstalk between TLR and DC-SIGN signalling results in TLR-induced MK2-mediated phosphorylation of LSP1, associated with DC-SIGN, upon fucose binding. Subsequently, IKKε and CYLD are recruited to phosphorylated LSP1...
  57. doi Fungal membrane organization: the eisosome concept
    Lois M Douglas
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794 email
    Annu Rev Microbiol 68:377-93. 2014
    ..associated with the cytoplasmic side of the MCC, including the Bin/amphiphysin/Rvs-domain proteins Pil1 and Lsp1, which assemble into filaments that curve the membrane to form the furrows...
  58. doi Fibrocytes participate in the development of heterotopic ossification
    Abelardo Medina
    From the Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Alberta, Edmonton, Canada Division of Critical Care Medicine and Firefighters Burn Treatment Unit, Department of Surgery, University of Alberta, Edmonton, Canada
    J Burn Care Res 36:394-404. 2015
    ..marrow derived fibrocyte profile consisting in spindle-shaped morphology associated with type 1 pro-collagen and LSP1 expression...
  59. doi Determination of the absolute configuration of phosphinic analogues of glutamate
    Bruno Commare
    Laboratoire de Chimie and Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Universite Paris Descartes, Sorbonne Paris Cité, 45, rue des Saints Pères 75270, Paris Cedex 06, France
    Org Biomol Chem 13:1106-12. 2015
    A series of phosphinic glutamate derivatives (e.g.LSP1-2111) have been proven to be potent agonists of metabotropic glutamate (mGlu) receptors and shown promising in vivo activity...
  60. doi The yeast BDF1 regulates endocytosis via LSP1 under salt stress
    Jiafang Fu
    Shandong Medicinal Biotechnology Centre, Shandong Academy of Medical Sciences, Jinan, 250062, China
    Curr Microbiol 70:671-8. 2015
    ..We deleted some of the most significant down-regulated genes and did the spot assay. The results revealed that LSP1, an upstream component of endocytosis pathway, and CIN5, a transcription factor that mediates cellular resistance ..
  61. doi A novel subpopulation of peripheral blood mononuclear cells presents in major burn patients
    Hongbin Liu
    Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, University of Alberta, 2D2 28 WMC, 8440 112 Street, Edmonton, AB, Canada T6G 2B7
    Burns 41:998-1007. 2015
    ..that appears at an early stage following major thermal injuries, which primarily express procollagen 1, leukocyte specific protein 1, CD204, toll-like receptor 4 and stromal cell-derived factor 1 (SDF-1) receptor CXCR4...
  62. pmc Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
    Hanna Iderberg
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Sweden Electronic address
    Neuropharmacology 95:121-9. 2015
    ..effects produced by the mGlu4 positive allosteric modulator (PAM), VU0364770, and the mGlu4 orthosteric agonist, LSP1-2111, in rats with unilateral 6-OHDA lesions...
  63. pmc Leukocyte-specific protein 1 regulates neutrophil recruitment in acute lung inflammation
    Nguyen Phuong Khanh Le
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam
    Am J Physiol Lung Cell Mol Physiol 309:L995-1008. 2015
    ..We explored the hitherto unknown expression of leukocyte-specific protein 1 (LSP1) in human and mouse lungs and neutrophils and examined its role in neutrophil migration in acute lung inflammation...
  64. pmc Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
    Seong Hye Hwang
    Postech Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Korea
    Proc Natl Acad Sci U S A 112:E6535-43. 2015
    ..Here, we identified a novel leukocyte-specific protein 1 (LSP1) deletion variant for RA susceptibility located in 11p15.5...
  65. ncbi Sequence conservation around the 5' ends of the larval serum protein 1 genes of Drosophila melanogaster
    S J Delaney
    J Mol Biol 189:1-11. 1986
    ..sequence at the 5' ends of the genes for the alpha, beta and gamma polypeptides of larval serum protein 1 (LSP1) of Drosophila melanogaster. In their upstream regions, the three genes share homology around the TATA boxes...
  66. ncbi The molecular cloning of a dispersed set of developmentally regulated genes which encode the major larval serum protein of D. melanogaster
    D F Smith
    Cell 23:441-9. 1981
    ..melanogaster DNA that encode the alpha, beta and gamma polypeptides of the major larval serum protein (LSP1) from libraries of recombinant phage...
  67. ncbi Protein kinase C phosphorylates p50 LSP1 and induces translocation of p50 LSP1 in T lymphocytes
    N Matsumoto
    Department of Parasitology, Institute of Medical Science, University of Tokyo
    J Biochem 117:222-9. 1995
    ..p50 was identified as lymphocyte specific protein 1 (LSP1), which is a putative calcium-binding protein...
  68. ncbi Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
    S Inui
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    J Immunol 154:2714-23. 1995
    ..These results suggested that the alpha 4 gene-encoded molecule is functionally involved in the IgR-mediated signal transduction in B cells...
  69. ncbi The mouse Lsp1 and Tnnt3 genes are 4.3 kb apart on distal mouse chromosome 7
    V L Misener
    University of Toronto Arthritis Centre of Excellence at the Toronto Hospital, Department of Immunology, University of Toronto, Ontario, Canada
    Mamm Genome 9:846-8. 1998
  70. ncbi Leucocyte-specific protein (LSP1) in malignant lymphoma and Hodgkin's disease
    Teresa Marafioti
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 120:671-8. 2003
    Biopsies from 319 haematopoietic neoplasms were immunostained for intracellular leucocyte-specific protein 1 (LSP1) to assess its distribution and to compare its diagnostic value with that of CD45 (leucocyte common antigen: LCA)...
  71. ncbi A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils
    Taisuke Ohira
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard University Medical School, Boston, MA 02115, USA
    J Immunol 173:2091-8. 2004
    ....
  72. pmc The echinocandin "target" identified by cross-linking is a homolog of Pil1 and Lsp1, sphingolipid-dependent regulators of cell wall integrity signaling
    Thomas D Edlind
    Antimicrob Agents Chemother 48:4491. 2004
  73. ncbi Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain
    Hongwei Qin
    Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Immunol 173:6211-9. 2004
    ....
  74. pmc LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration
    Lixin Liu
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Exp Med 201:409-18. 2005
    Leukocyte-specific protein 1 (LSP1), an F-actin binding protein and a major downstream substrate of p38 mitogen-activated protein kinase as well as protein kinase C, has been reported to be important in leukocyte chemotaxis...
  75. ncbi Identification of fibrocytes in postburn hypertrophic scar
    Liju Yang
    Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Wound Repair Regen 13:398-404. 2005
    ....
  76. ncbi Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  77. ncbi The immunohistochemical characterization of devil facial tumor disease (DFTD) in the Tasmanian Devil (Sarcophilus harrisii)
    R Loh
    Animal Health Laboratory, PO Box 46, Kings Meadows, 7249 Tasmania, Australia
    Vet Pathol 43:896-903. 2006
    ..actin (SMA) (0/26), desmin (0/47), glial fibrillary acid protein (0/13), CD16 (0/13), CD57 (0/43), CD3 (0/18), and LSP1 (0/16)...
  78. pmc Association of breast cancer susceptibility variants with risk of pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:3044-8. 2009
    ..Recently, several breast cancer susceptibility loci have been identified through genome-wide association studies. Here we evaluated possible associations between these single nucleotide polymorphisms (SNP) and pancreatic cancer risk...
  79. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  80. doi Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Erasmus MC, Building Be, Room 400, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Breast Cancer Res Treat 133:843-51. 2012
    ..was once established, we examined the association of SNPs tagging the low-risk breast cancer loci in or near FGFR2, LSP1, MAP3K1, H19, TOX3, POU5F1P1, MYC, and 2q35, with clinical, pathological characteristics, prognosis, and mRNA ..
  81. doi Breast cancer genome-wide association studies: there is strength in numbers
    D Fanale
    Department of Surgical and Oncological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
    Oncogene 31:2121-8. 2012
    ..in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-specific protein 1 (LSP1)...
  82. pmc Blood pressure loci identified with a gene-centric array
    Toby Johnson
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Am J Hum Genet 89:688-700. 2011
    ..We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0...
  83. pmc Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation
    Michael A Nalesnik
    Department of Pathology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15241, USA
    Am J Pathol 180:1495-508. 2012
    ..The LSP1 gene had the most cases with CNV (46 deletions and 5 amplifications)...
  84. doi Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1)
    N A Kahle
    Institut für Immunologie der Universität Heidelberg, Heidelberg, Germany
    Immunobiology 218:145-51. 2013
    ..In PMN, the major substrate of MK2 is the leukocyte specific protein 1 (LSP1), which binds to F-actin and participates directly in actin polymerization and cell migration...
  85. pmc MIR141 Expression Differentiates Hashimoto Thyroiditis from PTC and Benign Thyrocytes in Irish Archival Thyroid Tissues
    Emma R Dorris
    Department of Histopathology, Sir Patrick Dun Research Laboratory, Trinity College Dublin, St James Hospital Dublin, Ireland
    Front Endocrinol (Lausanne) 3:102. 2012
    ..Thyrocyte- and lymphocyte-specific markers (TSHR and LSP1, respectively), confirmed the integrity of cell populations in the HT cohort...
  86. pmc Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp
    Anil Prasad
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48854. 2012
    ..We further identified Leukocyte-Specific Protein 1 (LSP1) as a novel component of the WASp-Arp2/3-β-actin complex...
  87. pmc Antidiabetic Activity of Polysaccharides from Tuberous Root of Liriope spicata var. prolifera in KKAy Mice
    Yihui Liu
    Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China
    Evid Based Complement Alternat Med 2013:349790. 2013
    ..The present study investigated the antidiabetic effect and the potential mechanisms of two new polysaccharides (LSP1, LSP2) and the total polysaccharides (TLSP), isolated from the tuberous roots...
  88. doi Activation of metabotropic glutamate 4 receptors decreases L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease
    Sebastien Lopez
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Parkinsons Dis 1:339-46. 2011
    ..In this study, we examined a novel orthosteric agonist at the mGlu4 receptor, LSP1-2111, for its ability to affect L-DOPA-induced dyskinesia (LID), in a mouse model...
  89. pmc Membrane-sculpting BAR domains generate stable lipid microdomains
    Hongxia Zhao
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Cell Rep 4:1213-23. 2013
    ..BAR and Fes/CIP4 homology BAR (F-BAR) domains, the inverse BAR domain of Pinkbar, and the eisosomal BAR protein Lsp1 induced phosphoinositide clustering and halted lipid diffusion, despite differences in mechanisms of membrane ..
  90. pmc Culex quinquefasciatus storage proteins
    Larissa A Martins
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    PLoS ONE 8:e77664. 2013
    ..analysis of larval and pupal proteins identified all storage proteins with the exception of one encoded by Cq LSP1.8. Our results indicate that the identified Cx...
  91. ncbi The non-dosage compensated LSP1-alpha gene of Drosophila melanogaster lies immediately downstream of the dosage compensated L12 gene
    S Ghosh
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Mol Gen Genet 233:49-52. 1992
    The X-linked gene LSP1-alpha of Drosophila melanogaster, expressed in the third larval instar, does not exhibit dosage compensation at its normal locus but does compensate when it is relocated to ectopic sites on the X chromosome...
  92. ncbi Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen
    R K Kadiyala
    Department of Pediatrics, Stanford Medical School, CA 94305
    Eur J Immunol 20:2417-23. 1990
    ..Sequence analysis indicates that WP34 is the human homologue of the recently described murine molecule LSP1.
  93. pmc The LSP1-alpha gene of Drosophila melanogaster exhibits dosage compensation when it is relocated to a different site on the X chromosome
    S Ghosh
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    EMBO J 8:1191-6. 1989
    The LSP1-alpha gene of Drosophila melanogaster is located on the X chromosome at 11B yet is not dosage compensated...
  94. ncbi A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines
    J Jongstra
    Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 141:3999-4004. 1988
    The LSP1 gene is a new lymphocyte-specific gene which is expressed in normal mouse B and T lymphocytes and in transformed B cells but not (or in much smaller amounts) in nine T lymphoma lines tested...
  95. ncbi The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein
    T Howard
    Department of Pediatrics, University of Alabama, School of Medicine, Birmingham
    Blood 83:231-41. 1994
    ..native PMNs, 47-kD actin binding protein showed the overexpressed 47-kD protein is lymphocyte-specific protein 1 (LSP1), which is a known actin binding protein...
  96. ncbi Alternatively spliced pp52 mRNA in nonlymphoid stromal cells
    J M Gimble
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104
    J Immunol 150:115-21. 1993
    ..The nucleotide sequence of the S37 stromal cell cDNA is identical to that of the lymphocyte derived pp52 cDNA from the 3' poly(A) tail to the codon encoding the amino acid at residue 24...
  97. ncbi Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family
    W May
    Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, Cedars Sinai Medical Center, University of California, Los Angeles 90024
    Genomics 15:515-20. 1993
    ..function in B lymphocyte cell signaling, we isolated the human genomic counterpart of the murine pp52 or LSP1 gene. We unexpectedly found that the human pp52 gene is one of four closely related loci...
  98. ncbi Characterization and purification of a protein kinase C substrate in human B cells. Identification as lymphocyte-specific protein 1 (LSP1)
    E Carballo
    Biological Hematology Service, University of Barcelona, Spain
    J Immunol 156:1709-13. 1996
    ..p60 was purified from CESS cells and peptide microsequencing of this protein revealed that it was lymphocyte-specific protein 1 (LSP1), that is here characterized as the most prominent protein kinase C substrate in B cells.
  99. ncbi Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms
    A A Thompson
    Department of Pediatrics, UCLA School of Medicine 90095, USA
    Genomics 32:352-7. 1996
    The pp52 gene encodes an intracellular, F-actin-binding phosphoprotein (also designated LSP1 and WP34) postulated to function in cytoskeleton dynamics and cell motility...
  100. ncbi LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils
    C K Huang
    Department of Pathology, University of Connecticut Health Center, Farmington 06030 3105, USA
    J Biol Chem 272:17-9. 1997
    ..Microsequencing of five peptides derived from purified p60 indicates that p60 is lymphocyte-specific protein 1 (LSP1). Furthermore antibodies specific for human and mouse LSP1 react with human and mouse p60...
  101. ncbi Mosquito hexamerins: characterization during larval development
    S E Korochkina
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Insect Mol Biol 6:11-21. 1997
    ..Calliphora vicina, or to LSP1 or LSP2, the two distinct hexamerins of Drosophila melanogaster...

Research Grants11

  1. PHAGOCYTE MOTILITY--CELLULAR AND MOLECULAR CONTROL
    Thomas Howard; Fiscal Year: 1999
    ..and defective actin polymerization led to description of new disease, NAD47/89, with increased amounts of LSP1, as actin binding protein...
  2. CHEMOTACTIC NEURTROPHIL ACTIVATION AND PHOSPHOPROTEINS
    Chi Kuang Huang; Fiscal Year: 2001
    ..Much of this work concentrate on the recently identified substrate of the MAPKAP-kinase, (LSP1) lymphocytes specific protein 1...
  3. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006
    ..These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease. ..
  4. Tumor Markers and Recurrent Adenomas: A Follow-up Study
    Wei Zheng; Fiscal Year: 2006
    ..This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention. ..
  5. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..abstract_text> ..
  6. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  7. P21 INDUCTION BY BRCA2
    Fergus Couch; Fiscal Year: 2002
    ....
  8. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006
    ..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
  9. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2007
    ..The results from this study may guide new strategies in the primary prevention of common cancer in both Western and Asian women. ..
  10. MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCER
    Wei Zheng; Fiscal Year: 2009
    ..Results from this study will be valuable in identifying high risk women for primary and secondary prevention of breast cancer. ..
  11. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..Studies investigating gene-gene and gene-environment interaction could provide valuable information in identifying high-risk individuals for designing cost-effective preventive strategies for breast cancer. ..