LRP5

Summary

Gene Symbol: LRP5
Description: LDL receptor related protein 5
Alias: BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, low-density lipoprotein receptor-related protein 5, low density lipoprotein receptor-related protein 5, low density lipoprotein receptor-related protein 7
Species: human

Top Publications

  1. ncbi A mechanism for Wnt coreceptor activation
    Keiko Tamai
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 13:149-56. 2004
  2. ncbi Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma
    Bang H Hoang
    Department of Surgery, Orthopaedic Surgery Service, affiliated with Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 109:106-11. 2004
  3. ncbi SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    Mikhail Semenov
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26770-5. 2005
  4. ncbi LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    Mikhail V Semenov
    Neurobiology Program, Children s Hospital Boston, 61 Binmney Street, Boston, MA 02115, USA
    J Biol Chem 281:38276-84. 2006
  5. pmc Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q
    Carmel Toomes
    Molecular Medicine Unit, University of Leeds, Leeds, United Kingdom
    Am J Hum Genet 74:721-30. 2004
  6. doi LRP5 Polymorphisms and response to risedronate treatment in osteoporotic men
    Marcin Kruk
    Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK
    Calcif Tissue Int 84:171-9. 2009
  7. doi Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP
    Konstantinos Nikopoulos
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Hum Mutat 31:656-66. 2010
  8. pmc Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
    Shunfu Piao
    College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Korea
    PLoS ONE 3:e4046. 2008
  9. pmc Association between bone mineral density and LDL receptor-related protein 5 gene polymorphisms in young Korean men
    Jung Min Koh
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Korean Med Sci 19:407-12. 2004
  10. pmc Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13
    Y Gong
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA
    Am J Hum Genet 59:146-51. 1996

Detail Information

Publications220 found, 100 shown here

  1. ncbi A mechanism for Wnt coreceptor activation
    Keiko Tamai
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 13:149-56. 2004
    LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are single-span transmembrane proteins essential for Wnt/beta-catenin signaling, likely via acting as Wnt coreceptors...
  2. ncbi Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma
    Bang H Hoang
    Department of Surgery, Orthopaedic Surgery Service, affiliated with Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 109:106-11. 2004
    The Wingless-type (Wnt) family of proteins and its coreceptor LRP5 have recently been implicated in human skeletal development...
  3. ncbi SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    Mikhail Semenov
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26770-5. 2005
    ..shares remarkable similarities with "high bone mass" diseases caused by "gain-of-function" mutations in the LRP5 gene, which encodes a coreceptor for Wnt signaling proteins...
  4. ncbi LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    Mikhail V Semenov
    Neurobiology Program, Children s Hospital Boston, 61 Binmney Street, Boston, MA 02115, USA
    J Biol Chem 281:38276-84. 2006
    The low density lipoprotein (LDL) receptor-related protein 5 (LRP5) is a co-receptor for Wnt proteins and a major regulator in bone homeostasis...
  5. pmc Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q
    Carmel Toomes
    Molecular Medicine Unit, University of Leeds, Leeds, United Kingdom
    Am J Hum Genet 74:721-30. 2004
    ..Here, we describe mutations in a second gene at the EVR1 locus, low-density-lipoprotein receptor-related protein 5 (LRP5), a Wnt coreceptor...
  6. doi LRP5 Polymorphisms and response to risedronate treatment in osteoporotic men
    Marcin Kruk
    Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK
    Calcif Tissue Int 84:171-9. 2009
    ..Previous studies have shown that polymorphisms of the LRP5 gene are associated with bone mineral density (BMD), but the relationship between LRP5 polymorphisms and response ..
  7. doi Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP
    Konstantinos Nikopoulos
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Hum Mutat 31:656-66. 2010
    ..Mutations in the genes encoding the low density lipoprotein receptor protein 5 (LRP5) and frizzled 4 (FZD4), acting as coreceptors for Wnt ligands, cause familial exudative vitreoretinopathy (FEVR)...
  8. pmc Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
    Shunfu Piao
    College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Korea
    PLoS ONE 3:e4046. 2008
    ..These observations demonstrate that phosphorylated LRP6/5 both recruits and directly inhibits GSK3beta using two distinct portions of its cytoplasmic sequence, and suggest a novel mechanism of activation in this signaling pathway...
  9. pmc Association between bone mineral density and LDL receptor-related protein 5 gene polymorphisms in young Korean men
    Jung Min Koh
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Korean Med Sci 19:407-12. 2004
    Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) regulates bone formation, and that mutations of the gene cause osteoporosis-pseudoglioma syndrome or high bone mass phenotypes...
  10. pmc Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13
    Y Gong
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA
    Am J Hum Genet 59:146-51. 1996
    Osteoporosis-pseudoglioma syndrome (OPS) is an autosomal recessive disorder characterized by severe juvenile-onset osteoporosis and congenital or juvenile-onset blindness. The pathogenic mechanism is not known...
  11. ncbi Autosomal recessive familial exudative vitreoretinopathy: evidence for genetic heterogeneity
    G de Crecchio
    Eye Clinic, University of Naples, Italy
    Clin Genet 54:315-20. 1998
    ..Compared with the other modes of inheritance, the inherited clinical features here include earlier onset (at birth) and a more severe progressive course...
  12. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth...
  13. pmc Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density
    Liesbeth Van Wesenbeeck
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 72:763-71. 2003
    ..The LDL receptor-related protein 5 (LRP5) gene has been shown to be involved in both osteoporosis-pseudoglioma syndrome and the high-bone-mass phenotype and ..
  14. ncbi High bone mass in mice expressing a mutant LRP5 gene
    Philip Babij
    Genomics, Wyeth Research, Andover, Massachusetts, USA
    J Bone Miner Res 18:960-74. 2003
    A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice expressing this LRP5 mutation have a similar phenotype with high bone mass and enhanced strength...
  15. ncbi LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
    Xi He
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 131:1663-77. 2004
    ..Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are ..
  16. pmc Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:878-84. 2004
    ..This region contains LRP5 but not FZD4; mutations in both of these genes cause autosomal dominant FEVR...
  17. pmc Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study
    Yan Fang Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
    J Med Genet 43:798-803. 2006
    The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes.
  18. ncbi Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling
    Bheem M Bhat
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Gene 391:103-12. 2007
    A single point mutation (G to T) in the low-density lipoprotein receptor related protein 5 (LRP5) gene results in a glycine to valine amino acid change (G171V) and is responsible for an autosomal dominant high bone mass trait (HBM) in two ..
  19. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.
  20. doi Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake
    Maria G Stathopoulou
    Department of Dietetics and Nutrition, Harokopio University, 17671 Athens, Greece
    J Am Diet Assoc 110:1078-83. 2010
    The low-density lipoprotein receptor-related protein 5 (LRP5) has been shown to play a significant role in bone biology...
  21. doi Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication
    Jose A Riancho
    Department of Internal Medicine, Hospital U M Valdecilla IFIMAV, University of Cantabria, RETICEF, Avda Valdecilla s n, 39008 Santander, Spain
    Eur J Endocrinol 164:123-31. 2011
    ....
  22. doi Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women
    Anastasia E Markatseli
    Department of Endocrinology, University of Ioannina, Ioannina, Greece
    Maturitas 70:188-93. 2011
    Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation.
  23. pmc Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6
    Victoria E Ahn
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 21:862-73. 2011
    LDL receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Wnt growth factors, and also bind Dkk proteins, secreted inhibitors of Wnt signaling. The LRP5/6 ectodomain contains four β-propeller/EGF-like domain repeats...
  24. ncbi The importance of Wnt signalling for neurodegeneration in Parkinson's disease
    Daniel C Berwick
    Department of Pharmacology, UCL School of Pharmacy, University College London, 29 39 Brunswick Square, London WC1N 1AX, U K
    Biochem Soc Trans 40:1123-8. 2012
    ..This suggests the prospect of targeting Wnt signalling pathways to modify PD progression...
  25. pmc Identification of FZD4 and LRP5 mutations in 11 of 49 families with familial exudative vitreoretinopathy
    Huiqin Yang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Mol Vis 18:2438-46. 2012
    To identify mutations in FZD4 and LRP5 in 49 Chinese families with familial exudative vitreoretinopathy (FEVR) and to reveal the mutation spectrum and frequency of these genes in the Chinese population.
  26. doi Association of LRP5 haplotypes with osteoporosis in Mexican women
    Edith Falcón-Ramírez
    Direccion de Investigacion, Servicio de Genetica, Instituto Nacional de Rehabilitacion, Calzada México Xochimilco No 289 Arenal de Guadalupe, 14389, Mexico, D F, Mexico
    Mol Biol Rep 40:2705-10. 2013
    ..G/A rs4988321, T/C rs627174 and T/C rs901824) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) and their association with osteoporosis in 100 pos-menopausal osteoporotic Mexican women and their controls, using ..
  27. pmc Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)
    M L Johnson
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131 5149, USA
    Am J Hum Genet 60:1326-32. 1997
    The purpose of this paper is to report the linkage of a genetic locus (designated "HBM") in the human genome to a phenotype of very high spinal bone density, using a single extended pedigree...
  28. ncbi Cloning of a novel member of the low-density lipoprotein receptor family
    P J Hey
    Merck Research Laboratories, Department of Human Genetics, West Point, PA 19486, USA
    Gene 216:103-11. 1998
    ..The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains conserved modules which are characteristic of the low-density ..
  29. ncbi LDL-receptor-related proteins in Wnt signal transduction
    K Tamai
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:530-5. 2000
    ..is homologous to two members of the mammalian low-density lipoprotein receptor (LDLR)-related protein (LRP) family, LRP5 and LRP6 (refs 12-15). Here we report that LRP6 functions as a co-receptor for Wnt signal transduction...
  30. ncbi Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    J Mao
    Department of Genetics and Developmental Biology, University of Connecticut, Farmington, CT 06030, USA
    Mol Cell 7:801-9. 2001
    ..In addition, the LRP-5 sequences involved in interactions with Axin are required for LEF-1 activation. Thus, we conclude that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway...
  31. ncbi Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    A Bafico
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, Box 1130, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Cell Biol 3:683-6. 2001
    ....
  32. ncbi Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    M V Semenov
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 11:951-61. 2001
    ..The significance of the Fz-LRP6 complex in signal transduction remains to be established...
  33. pmc A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..amino acid change, in a predicted beta-propeller module of the low-density lipoprotein receptor-related protein 5 (LRP5), that results in the HBM phenotype...
  34. ncbi Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene
    Minoru Okubo
    Department of Endocrinology and Metabolism, Okinaka Memorial Institute for Medical Research and Toranomon Hospital, Tokyo, Japan
    Hum Mutat 19:186. 2002
    We identified seven novel polymorphisms in the human low density lipoprotein receptor related protein 5 (LRP5) gene. Two of them are predicted to replace amino acid in LRP5 protein (c.314A>G: Q89R and c...
  35. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
    ..Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis-pseudoglioma.
  36. ncbi A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 277:34727-35. 2002
    ..by binding to seven-transmembrane spanning receptors of the Frizzled (Fz) family together with the coreceptors LRP5 and -6, members of the low density lipoprotein receptor-related protein family (LRP)...
  37. pmc Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
    Takahiro Fujino
    Gene Research Center and Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University, Sendai 980 8574, Japan
    Proc Natl Acad Sci U S A 100:229-34. 2003
    A Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) plays an essential role in bone accrual and eye development. Here, we show that LRP5 is also required for normal cholesterol and glucose metabolism...
  38. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ..MESD functions in the endoplasmic reticulum as a specific chaperone for LRP5 and LRP6, which in conjunction with Frizzled, are coreceptors for canonical WNT signal transduction...
  39. ncbi LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density
    Takeshi Mizuguchi
    Department of Human Genetics, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1 12 4, Nagasaki 852 8523, Japan
    J Hum Genet 49:80-6. 2004
    ..association study between BMD and nine candidate genes ( TGFB1, TGFBR2, SMAD2, SMAD3, SMAD4, IFNB1, IFNAR1, FOS and LRP5), as well as of a case-control study of osteoporosis...
  40. ncbi Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
    Qiang Xu
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 116:883-95. 2004
    ..These data define a Norrin-Fz4 signaling system that plays a central role in vascular development in the eye and ear, and they indicate that ligands unrelated to Wnts can act through Fz receptors...
  41. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites
    Serge L Ferrari
    Division of Bone Diseases, University Hospital of Geneva, Geneva 1211, Switzerland
    Am J Hum Genet 74:866-75. 2004
    ..and stature at chromosome 11q12-13, a region harboring the low-density lipoprotein receptor-related protein 5 (LRP5) gene...
  42. ncbi Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    J Bone Miner Metab 22:341-5. 2004
    Low-density lipoprotein receptor-related protein 5 (LRP5) is an important regulator of osteoblast growth and differentiation, affecting peak bone mass in vertebrates...
  43. ncbi Influence of LRP5 polymorphisms on normal variation in BMD
    M Audrey Koay
    Institute of Musculoskeletal Sciences, University of Oxford, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, UK
    J Bone Miner Res 19:1619-27. 2004
    Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD...
  44. ncbi Contribution of the LRP5 gene to normal variation in peak BMD in women
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:75-80. 2005
    The role of the LRP5 gene in rare BMD-related traits has recently been shown. We tested whether variation in this gene might play a role in normal variation in peak BMD...
  45. ncbi LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women
    J Bollerslev
    School of Medicine and Pharmacology, University of Western Australia, Nedlands
    Bone 36:599-606. 2005
    ..The importance of LDL receptor-related protein 5 (LRP5) for the regulation of bone mass has recently been established, where loss of function mutations is followed by ..
  46. ncbi Genetic and environmental determinants of bone mineral density in Chinese women
    H H L Lau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Bone 36:700-9. 2005
    ..receptor (CASR), vitamin D receptor (VDR), collagen type Ialpha1 (COLIA1), and LDL receptor-related protein 5 (LRP5)...
  47. ncbi Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children
    Heini Hartikka
    Collagen Research Unit, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    J Bone Miner Res 20:783-9. 2005
    Three of 20 patients with juvenile osteoporosis were found to have a heterozygous mutation in the LRP5 gene. No mutations were found in the type I collagen genes...
  48. pmc Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling
    Minrong Ai
    Department of Genetics and Center for Human Genetics, Case School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Mol Cell Biol 25:4946-55. 2005
    The low-density-lipoprotein receptor-related protein 5 (LRP5), a coreceptor in the canonical Wnt signaling pathway, has been implicated in human disorders of low and high bone mass...
  49. ncbi Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis?
    A J P Smith
    University of Bristol Department of Pathology and Microbiology, Homoeopathic Hospital Site, Cotham, Bristol BS6 6JU, UK
    Osteoarthritis Cartilage 13:608-13. 2005
    ..locus on chromosome 11q in close proximity to the low-density lipoprotein receptor-related protein 5 (LRP5) gene...
  50. ncbi Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes
    Minghui Qin
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hum Mutat 26:104-12. 2005
    ..the genes encoding the Wnt receptor pair, frizzled 4 (FZD4) and low-density-lipoprotein receptor-related protein 5 (LRP5), have been shown to cause FEVR...
  51. ncbi Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women
    Zhen Lin Zhang
    Center for Preventing and Treating Osteoporosis, Osteoporosis Research Unit, The Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Acta Pharmacol Sin 26:1111-6. 2005
    To investigate the possible association of Q89R, N740N and A1330V polymorphisms in low-density lipoprotein receptor-related protein 5 (LRP5) gene with bone mineral density (BMD) in postmenopausal Chinese women.
  52. ncbi LRP5 gene polymorphisms and idiopathic osteoporosis in men
    S L Ferrari
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
    Bone 37:770-5. 2005
    Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) have demonstrated the role of LRP5 in bone mass acquisition...
  53. ncbi Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men
    Patricia Crabbe
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
    J Bone Miner Res 20:1951-9. 2005
    We studied whether the LRP5 gene contributes to the clinical phenotype of IO in men. Mutation analysis in 66 IO men revealed a range of sequence variants, of which two missense variants were shown to be of functional relevance.
  54. ncbi Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:141-50. 2006
    Both LRP5 and LRP6 genes have been implicated to play a role in bone metabolism. In a large population-based study, we related common variation in both genes to bone parameters and fractures...
  55. ncbi Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiation
    J Guo
    Curriculum in Oral Biology, Bone Biology and Implant Therapy Laboratory, 404 Brauer Hall, CB 7450 School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
    Bone 40:57-67. 2007
    The low density lipoprotein receptor-related protein 5 (LRP5) is a key determinant of bone mass, via the Wnt signaling pathway control of osteoblast function...
  56. ncbi Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
    Debra L Ellies
    Stowers Institute for Medical Research, Kansa City, Missouri 64110, USA
    J Bone Miner Res 21:1738-49. 2006
    ..Our data suggest that functional interactions between Sost or Wise and LRP5/LRP6 have the potential to regulate bone deposition by modulating the Wnt pathway.
  57. pmc Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
    Bone 40:587-96. 2007
    Polymorphisms in the LRP5 gene have been associated with bone mineral density (BMD) in men and/or women. However, the functional basis for this association remains obscure...
  58. ncbi Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    J Bone Miner Res 22:385-93. 2007
    In this study, the associations of novel LRP5 variants with BMD variation were detected and some replicated in the two ethnic groups of Chinese and white origins, respectively...
  59. ncbi Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women
    Yoichi Ezura
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1 396, Kosugi cho, Nakahara ku, Kawasaki 211 8533, Japan
    Bone 40:997-1005. 2007
    Low-density lipoprotein receptor-related protein 5 (LRP5), a co-receptor of Wnt signaling, is an important regulator of bone development and maintenance...
  60. ncbi LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women
    Sylvie Giroux
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de Recherche de l Hôpital St François d Assise du Centre Hospitalier Universitaire de Québec, Quebec, Canada G1L 3L5
    Bone 40:1299-307. 2007
    ..b>LRP5 gene was previously shown to be involved in rare diseases affecting bone mass...
  61. ncbi Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone
    Z G Li
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Oncogene 27:596-603. 2008
    ..MDA PCa 2b cells did not induce bone formation in calvaria from mice lacking the Wnt co-receptor Lrp5. In human specimens, WNT7b was not expressed in normal prostate but was expressed in areas of high-grade prostate ..
  62. ncbi Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy
    Minghui Qin
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hum Genet 122:615-23. 2008
    Mutations in Norrin signaling genes (NDP, FZD4 and LRP5) have been found in patients with familial exudative vitreoretinopathy (FEVR) and the altered signaling is suspected to play a critical role in its pathogenesis...
  63. ncbi Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men
    E Grundberg
    Department of Medical Sciences, Uppsala University Hospital, 75185 Uppsala, Sweden
    Osteoporos Int 19:829-37. 2008
    Herein we investigated the association between polymorphisms in the LRP5 gene and bone phenotypes and fractures in three large male cohorts based on the rationale that mutations in LRP5 cause severe bone phenotypes...
  64. pmc An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling
    Peyman Björklund
    Department of Surgical Sciences, Uppsala University, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 4:e328. 2007
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  65. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study
    K Brixen
    Department of Endocrinology, Odense University Hospital, 5000, Odense C, Denmark
    Calcif Tissue Int 81:421-9. 2007
    To investigate the impact of the Ala1330Val (rs3736228, exon 18) and Val667Met (rs4988321, exon 9) polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene on peak bone mass in young men.
  66. doi Replication of associations between LRP5 and ESRRA variants and bone density in premenopausal women
    S Giroux
    Centre de Recherche de l Hôpital, St François d Assise, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    Osteoporos Int 19:1769-75. 2008
    ..The low density lipoprotein receptor-related protein 5 (LRP5) Val667Met and lumbar spine bone density are replicated...
  67. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  68. pmc Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism
    Ke Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:23371-5. 2008
    ..These results suggest that Kremen may not be essential for Dkk1-mediated Wnt antagonism and that Kremen may only play a role when cells express a high level of LRP5/6.
  69. doi The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Calcif Tissue Int 82:445-53. 2008
    Low-density lipoprotein receptor-related protein 5 (LRP5), a Wnt coreceptor, plays an important role in bone metabolism as loss-of-function and gain-of-function mutations in LRP5 result in the autosomal recessive osteoporosis-pseudoglioma ..
  70. pmc Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis
    Bich N H Tran
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    BMC Med Genet 9:55. 2008
    The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in BMD in high bone mass pedigrees...
  71. doi Association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea
    Rheumatol Int 29:539-44. 2009
    The association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density (BMD) has been studied, but results have been mixed...
  72. doi A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:140-6. 2009
    We attempted to determine whether the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene is associated with a risk of self-reported incident fractures and hypercholesterolemia in Japanese patients ..
  73. doi A mutation in the signal sequence of LRP5 in a family with an osteoporosis-pseudoglioma syndrome (OPPG)-like phenotype indicates a novel disease mechanism for trinucleotide repeats
    Boi Dinh Chung
    Institute of Human Genetics, University of Cologne, Cologne, Germany
    Hum Mutat 30:641-8. 2009
    ..of phenotypes caused by mutations in the Wnt/Norrin coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) by identifying two novel types of mutation in related individuals whose presenting features were profound muscle ..
  74. ncbi A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Endocr J 56:625-31. 2009
    ..The Wnt co-receptor, namely, low-density lipoprotein receptor-related protein 5 (LRP5), initiates Wnt signal transduction...
  75. doi Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia
    Anne Saarinen
    Folkhalsan Institute of Genetics, University of Helsinki, Helsinki, Finland
    Clin Endocrinol (Oxf) 72:481-8. 2010
    Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) underlie osteoporosis-pseudoglioma syndrome. Animal models implicate a role for LRP5 in lipid and glucose homeostasis...
  76. doi Low-density lipoprotein receptor-related protein 5 (LRP5) expression in human osteoarthritic chondrocytes
    Ioanna Papathanasiou
    University of Thessaly, Medical School, Laboratory of Cytogenetics and Molecular Genetics, Larissa, Greece
    J Orthop Res 28:348-53. 2010
    ..the Wnt/beta-catenin pathway in osteoarthritis and the role of low-density lipoprotein receptor-related protein 5 (LRP5) in human osteoarthritic chondrocytes...
  77. pmc Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
    Eric Bourhis
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 285:9172-9. 2010
    ..of secreted Wnt with its receptors Frizzled (Fz) and low density lipoprotein receptor-related protein 5/6 (LRP5/6)...
  78. doi Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Endocrinol Metab 95:E112-20. 2010
    ..However, none of these has been fully investigated in Han Chinese populations...
  79. pmc No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families
    Jin Bo Yu
    Department of Osteoporosis and Bone Diseases, The Shanghai Sixth People s Hospital, Shanghai Jiaotong University, China
    Acta Pharmacol Sin 31:1464-9. 2010
    To investigate the effect of low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms on bone and obesity phenotypes in young Chinese men.
  80. ncbi Relationship between changes of bone mineral density over seven years and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene or lifestyle factors in Japanese female workers
    Yayoi Funakoshi
    Department of Public Health, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Asia Pac J Clin Nutr 19:534-9. 2010
    ..BMD) over a seven-year period and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene or lifestyle factors...
  81. doi Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5
    Morten Frost
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    J Bone Miner Res 26:1721-8. 2011
    Patients with an activation mutation of the Lrp5 gene exhibit high bone mass (HBM). Limited information is available regarding compartment-specific changes in bone...
  82. pmc Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG)
    C M Laine
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Eur J Hum Genet 19:875-81. 2011
    ..caused by biallelic loss-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene. Heterozygous carriers exhibit a milder bone phenotype...
  83. doi Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation
    Lidia Agueda
    Department of Genetics, Faculty of Biology, University of Barcelona, IBUB, CIBERER, Barcelona, Spain
    J Bone Miner Res 26:1133-44. 2011
    b>LRP5 is an osteoporosis susceptibility gene. Association analyses reveal that individual single-nucleotide polymorphisms (SNPs) determine variation in bone mineral density (BMD) among individuals as well as fracture risk...
  84. pmc Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis
    Payam Shahi
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e30814. 2012
    ..technology, we were able to modify the Wnt co-receptor, low-density lipoprotein (LDL)-receptor-related protein 5 (LRP5), to generate the synthetic ligand inducible Wnt switch, iLRP5...
  85. doi Genetic predictors of skeletal outcomes in healthy fertile women: the Bonturno study
    Francesco Massart
    Pediatric Unit, Santa Chiara University Hospital of Pisa, Pisa, Italy
    Joint Bone Spine 80:414-9. 2013
    ..Low-density lipoprotein receptor-related protein 5 (LRP5) and farnesyl diphosphonate synthase (FDPS) are candidate genes for bone phenotypes...
  86. ncbi 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription
    Jackie A Fretz
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:2215-30. 2006
    ..orchestrated by the Wnt signaling pathway wherein stimulation of the membrane receptor Frizzled and its coreceptor LRP5 leads to activation of beta-catenin and subsequent transcription-mediated changes in osteoblast biology...
  87. ncbi The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men
    Anne Saarinen
    Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Bone 40:1006-12. 2007
    Polymorphisms in the gene coding for low-density lipoprotein receptor-related protein 5 (LRP5) contribute to variation in bone mass in the general population...
  88. doi Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6
    Damien Fleury
    Protein Sciences, Galapagos, 102 route Gaston Roussel, F 93230 Romainville, France
    Protein Expr Purif 70:39-47. 2010
    ..by seven-transmembrane Frizzled (Fz) proteins and the single-transmembrane LDL-receptor-related proteins 5 or 6 (LRP5/6)...
  89. ncbi [Activity of esterases and effect of genetic polymorphism in workers exposed to organophosphorus pesticides]
    Xing ya Kuang
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai 200032, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:333-6. 2006
    ..BchE), carboxylesterase (CarbE), paraoxonase (PonE) and acetylcholinesterase (AChE), and to explore the effect of genetic polymorphism on the activity of esterase for workers exposed to organophosphorus pesticides (OPs).
  90. ncbi The role of oximes in the management of organophosphorus pesticide poisoning
    Peter Eyer
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University, Munich, Germany
    Toxicol Rev 22:165-90. 2003
    The number of intoxications with organophosphorus pesticides (OPs) is estimated at some 3,000,000 per year, and the number of deaths and casualties some 300,000 per year...
  91. ncbi Adsorption and selectivity characteristics of several human serum proteins with immobilised hard Lewis metal ion-chelate adsorbents
    M Zachariou
    Centre for Bioprocess Technology, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Chromatogr A 890:95-116. 2000
    ..Specifically, the binding properties of immobilised O-phosphoserine (im-OPS) and 8-hydroxyquinoline (im-8-HQ), with immobilised iminodiacetic acid as a control system, have been investigated ..
  92. ncbi Clonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial
    H T G Bergendahl
    Department of Paediatric Anaesthesia and Intensive Care, Astrid Lindgrens Children s Hospital, Stockholm, Sweden
    Acta Anaesthesiol Scand 48:1292-300. 2004
    ..The aim of the current study was to compare postoperative outcome variables using a prospective, randomized, double-blind design after premedication with clonidine or midazolam...
  93. ncbi Bioscavengers for the protection of humans against organophosphate toxicity
    Bhupendra P Doctor
    Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Road, Silver Spring, MD 20910, USA
    Chem Biol Interact 157:167-71. 2005
    ..EqBChE) or human serum BChE (HuBChE) protected the animals from multiple LD50s of a variety of highly toxic OPs without any toxic effects or performance decrements...
  94. doi Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study
    Melpomeni Tryfonos
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, GR 54124 Thessaloniki, Greece
    Aquat Toxicol 94:211-8. 2009
    Organophosphates (OPs) can provoke toxicity by inhibiting acetylcholinesterase (AChE) in non-target organisms, like fish...
  95. doi Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels
    Jeffrey B Eells
    Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, USA
    Neurotoxicol Teratol 31:98-103. 2009
    Organophosphates (OPs), commonly used as insecticides, inhibit acetylcholinesterase, the enzyme responsible for the inactivation of synaptic acetylcholine, which results in elevated acetylcholine neurotransmission...
  96. ncbi Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina
    Richard D Newcomb
    Gene Technologies Sector, The Horticulture and Food Research Institute of New Zealand, Private Bag 92169 Auckland, New Zealand
    J Mol Evol 60:207-20. 2005
    ..Gly137Asp confers resistance to organophosphorus insecticides (OPs), particularly preferring diethyl OPs such as diazinon, while Trp251Leu prefers dimethyl OPs, and particularly ..
  97. doi Improved performance of Brucella melitensis native hapten over Brucella abortus OPS tracer on goat antibody detection by the fluorescence polarization assay
    C Ramirez-Pfeiffer
    Instituto Nacional de Investigaciones Forestales y Agropecuarias, Campo Experimental Río Bravo, Rio Bravo, Tamaulipas, Mexico
    Vet Immunol Immunopathol 123:223-9. 2008
    ..Furthermore, results of the fluorescence polarization assay (FPA) using the Brucella abortus O-polysaccharide (OPS) tracer in goats are poorer than those with cattle...
  98. ncbi Continuous release of secretory granule proteoglycans from a cell strain derived from the bone marrow of a patient with diffuse cutaneous mastocytosis
    S A Krilis
    School of Medicine, University of New South Wales Australia
    Blood 79:144-51. 1992
    A human cell strain (designated HBM-M) that was derived from the bone marrow of a child with diffuse cutaneous mastocytosis was previously found to possess features that suggested it belonged in the mast cell/monocyte lineage...
  99. ncbi Biomechanics of vibration reception in the bullfrog, Rana catesbeiana
    T E Hetherington
    Department of Zoology, Ohio State University, Columbus 43210 1293
    J Comp Physiol A 163:43-52. 1988
    The opercularis system (OPS) of amphibians consists of an opercularis muscle that connects the shoulder girdle skeleton to the operculum, a movable element in the oval window of the otic capsule...
  100. ncbi Human biomonitoring: state of the art
    Jurgen Angerer
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 210:201-28. 2007
    Human biomonitoring (HBM) of dose and biochemical effect nowadays has tremendous utility providing an efficient and cost effective means of measuring human exposure to chemical substances...
  101. ncbi Multiresidue determination of persistent organochlorine and organophosphorus compounds in whale tissues using automated liquid chromatographic clean up and gas chromatographic-mass spectrometric detection
    R Serrano
    Department of Experimental Sciences, University Jaume I, , Spain
    J Chromatogr A 855:633-43. 1999
    ..validated by means of recovery tests for all the compounds detected in the whale and also for some other OCs and OPs studied in this paper...

Research Grants63

  1. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    The nerve agents soman, sarin and VX are organophosphorus compounds (OPs) chemically related to, but far more toxic than OP insecticides...
  2. Asthma Exacerbation by Organophosphate Pesticides
    ALLISON DEBORAH FRYER; Fiscal Year: 2011
    We have published papers demonstrating that organophosphates (OPs) induce airway hyperreactivity that is dose related, associated with loss of inhibitory neuronal M2 receptor function that normally limit acetylcholine release, and occurs ..
  3. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  4. Nanoparticle Defense for Agrichemical Exposures
    CHARLES MARK THOMPSON; Fiscal Year: 2012
    ..of a polymerized liposome nanoparticle (PLN) displays functional acetylcholinesterase, the primary target for OPs, while a therapeutic cargo is encapsulated (e.g., oxime)...
  5. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..b>OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal ..
  6. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2013
    unreadable] PROJECT SUMMARY Organophosphates (OPs) pose a constant threat to human health due to their widespread use as pesticides and their potential employment in terrorist attacks...
  7. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..Pesticides, such as organophosphates (OPs), are environmental toxicants that can be detoxified by CES;however, CES are irreversibly inhibited by the ..
  8. Organophosphate Action in the Central Nervous System
    NEIL MARC NATHANSON; Fiscal Year: 2012
    ..b>OPs are irreversible acetylcholinesterase inhibitors which can cause death due to overstimulation of both central and ..
  9. DNA methylation alterations in response to pesticides exposure
    Lifang Hou; Fiscal Year: 2010
    ..Our preliminary data recently linked exposure to organophosphate pesticides (OPs), the most commonly used insecticides in the US, to increased promoter methylation of several tumor suppressor ..
  10. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): P.I. Rosenberg, Y.J. ABSTRACT Organophosphorus (OPs) compound are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture; most notably as insecticides...
  11. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..and common environmental exposures, specifically polychlorinated biphenyls (PCBs), DDT, organophosphates (OPs), and pyrethroids (PYRs)...
  12. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ..Pesticides and OPs are significant terrorist threats to civilian populations...
  13. Pesticides, Paraoxonase and Alzheimer's Disease
    Mark S Kindy; Fiscal Year: 2010
    ..The focus of this proposal is to understand the function of organophosphates (OPs as symbolic ETs) and interrelationship between ETs and paraoxonase (PON-1) in oxidative stress and inflammation ..
  14. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Organophosphorus (OPs) compound are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture;most notably as insecticides...
  15. YVONNE J ROSENBERG; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Organophosphorus (OPs) compound are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture;most notably as insecticides...
  16. Neurotoxicity of organophosphorus pesticides in developing guinea pigs
    William Randall; Fiscal Year: 2013
    ..In addition, even though concerns regarding the toxicity of OPs to the developing brain have been substantiated by their prompt permeation through the placenta, there have been no ..
  17. Impact of Pesticide Exposure on Cognition in Children
    THOMAS PETROS; Fiscal Year: 2004
    ..of previous studies have documented that exposure to cholinesterase-inhibiting pesticides such as organophosphates (OPS) and carbamates constitutes a major health problem...
  18. Center of Catalytic Bioscanvenger Medical Defense Research II: Discovery, Formula
    Dan S Tawfik; Fiscal Year: 2013
    ..They will also be designed to possess high catalytic efficiency, which will allow for the rapid detoxification of OPs in the blood of exposed individuals...
  19. Diane S Rohlman; Fiscal Year: 2016
    ..endpoint;the long-term effects of repeated occupational and environmental exposures to organophosphorus pesticides (OPs) remain poorly understood...
  20. Assessing Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
    Diane S Rohlman; Fiscal Year: 2010
    ..application is to examine the dose-related response of the adolescent nervous system to organophosporus pesticides (OPs), to determine if repeated exposures produce a progressive deficit and to determine if this deficit is reversible...
  21. Mechanism of organophosphate development neurotoxicity
    Pamela Lein; Fiscal Year: 2003
    ..There is increasing concern that perinatal exposure to organophosphate acetylcholinesterase (AChE) inhibitors (OPs) may cause cognitive problems in children...
  22. Biomarkers of Organophosphate-Adducted Proteins
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..In addition to general exposure and food contamination, the safety of OPs is a large public health concern because OPs share chemical traits, structure and biological mechanism with nerve ..
  23. William I Weis; Fiscal Year: 2015
    ..Frizzled proteins (Frz), and single pass transmembrane receptors called LDL-receptor related proteins 5 and 6 (Lrp5/6)...
  24. Steven B Bird; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  25. Molecular basis of Wnt receptor interactions
    William I Weis; Fiscal Year: 2010
    ..Wnts bind to two co-receptors: the Frizzled proteins (Frz), and LDL-receptor related proteins 5 and 6 (Lrp5/6)...
  26. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  27. Counteracting acute and persistent effects of OP intoxication by endocannabinoids
    Carey N Pope; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Exposure to organophosphorus chemicals (OPs) can lead to life-threatening acute toxicity as well as persistent neuropsychological disturbances lasting years ..
  28. Pamela Lein; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): We have demonstrated that in a guinea pig model, organophosphorus pesticides (OPs) cause airway hyperreactivity that is dose-related and associated with the functional loss of autoinhibitory ..
  29. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
    ..with optimized oxime reactivators should completely and rapidly, in a several minute timeframe, hydrolyze OPs in plasma space following exposure to an order of magnitude higher then LD50 OP doses at a fraction of cost of ..
  30. Diet by Gene Interactions Affecting Calcium and Bone Metabolism
    James C Fleet; Fiscal Year: 2010
    ..developed three specific aims (SA): SA1: Test whether dietary Ca intake influences the ability of mice with the LRP5 G171V polymorphism to reach their genetic potential for high bone mass...
  31. Targeted Paraoxonase Fusion Protein as a Neurotherapeutic for Nerve Gas Agents
    RUBEN BOADO; Fiscal Year: 2009
    ..by applicant): Civilian populations are at risk for exposure to chemical nerve gas agents such as organophosphates (OPs). These compounds affect both the peripheral nervous system (PNS) and the central nervous system (CNS)...
  32. PON1 and Developmental Sensitivity to OP Pesticides
    Nina T Holland; Fiscal Year: 2010
    ..However, given the same exposure, some individuals may be more susceptible to the adverse effects of OPs depending on their genetic makeup and expression of genes encoding key metabolic enzymes...
  33. Therapeutics for increasing Bone Density and Quality
    DEBRA ELLIES; Fiscal Year: 2006
    ..Bone deposition, on the other hand, is now known to be under the control of the WNT pathway co-receptor LRP5. The human high bone mass trait results from a G171V point mutation in LRP5, whereas, the LRP5 loss of function ..
  34. Developing A Novel Therapy for Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2013
    ..Wnt pathway, while only two cell surface co-receptors, low-density lipoprotein receptor-related protein 5 and 6 (LRP5 &6), are essential for the activation of Wnt pathway...
  35. Jeremy Nathans; Fiscal Year: 2016
    ..Norrin binds with high affinity to a receptor protein, Frizzled4, which, together with two other proteins, Lrp5 and Tspan12, are present on the surface membrane of vascular cells...
  36. Structure of sclerostin protein complexes
    Rajiv Kumar; Fiscal Year: 2012
    ..protein 6 (BMP6), cysteine-rich protein 61 (Cyr61) and low-density-lipoprotein receptor-related protein 5 (LRP5) are key sclerostin-associating proteins reported to mediate sclerostin activity...
  37. Development and Testing of Novel Glanders Vaccine Candidates
    Paul J Brett; Fiscal Year: 2011
    ..Previous studies have demonstrated that the O-polysaccharide (OPS) expressed by B. mallei is both a virulence determinant and a protective antigen...
  38. Ryan C Riddle; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Since the identification of causative mutations in Lrp5 in osteoporosis-pseudoglioma and the high bone mass syndrome, the low-density lipoprotein receptor-related protein 5 (Lrp5) has been firmly ..
  39. CSF-1 in Dental Biology
    SHERRY L ABBOUD-WERNER; Fiscal Year: 2012
    ..Transgenic op/op mice expressing either csCSF-1 (op/opCS) or sCSF-1 (op/opS) in odontoblasts under the control of the osteocalcin (OC) promoter were generated and showed distinct tooth ..
  40. A Test of an Intervention to Improve Pap Testing Among Women with HIV
    Jeanne Murphy; Fiscal Year: 2013
    ..The study is informed by the Health Belief Model (HBM), which posits that screening behavior will increase if persons at risk for disease have a cue to action that ..
  41. Donita C Brady; Fiscal Year: 2015
    ..by the DCI and School of Medicine (SOM), the support and resources provided by the Office of Postdoctoral Services (OPS) at Duke University, and the experience, commitment and support from my mentor, Christopher M. Counter, Ph.D...
  42. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini M Rajamannan; Fiscal Year: 2011
    ..We hypothesize that lipids regulate the Lrp5/Wnt/b-catenin cascade in aortic valve myofibroblast cells to express the osteogenic gene program...
  43. Regulation of sclerostin expression by hypoxia: A proposed mechanism to explain h
    Damian C Genetos; Fiscal Year: 2012
    ..Provided the ample evidence that independently implicates the Wnt/Lrp5/sclerostin axis and the anabolic effect of hypoxia in mediating both embryonic and post- natal skeletal development,..
  44. Molecular mechanisms of medial calcification: regulation by transglutaminase 2
    Maria Nurminskaya; Fiscal Year: 2012
    ..same time, TG2 activates 2-catenin in VSMCs and binds to the Low-density lipoprotein receptor-related proteins 5/6 (LRP5/6) - the key receptors of the canonical Wnt/2-catenin signaling...
  45. Udayan Apte; Fiscal Year: 2016
    ..aim will determine the role of each component of canonical Wnt pathway including ?-catenin, GSK3?, disheveled, Lrp5 and Wnt4 in liver regeneration after ALF...
  46. Does increasing bone mass also increase bone strength in mouse models of OI?
    Matthew L Warman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We and other investigators have demonstrated the importance of LRP5 and LRP6 signaling for affecting bone mass and bone strength in humans and in mice...
  47. Xi He; Fiscal Year: 2015
    ..for human bone mass regulation, as loss-of-function and 'gain-of-function'mutations in Wnt coreceptor LRP5 are associated with familial osteoporosis and high bone mass diseases, respectively...
  48. Devendra K Agrawal; Fiscal Year: 2016
    ..We will examine the role of Wnt/[unreadable]-catenin signaling molecules, particularly [unreadable]-catenin, LRP5 and Kremen1, as the underlying mechanism of MSCs differentiation into ECs and re-endothelialization both in vitro ..
  49. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    CAROLINE MARGARET ALEXANDER; Fiscal Year: 2012
    ..of the origin of carcinogen-induced tumors (using a newly developed mouse strain based on the discovery of LRP5 as a mammary stem cell biomarker), the discovery of the cellular mechanism of tumor protection in Sdc1-/- mice, a ..
  50. Wnt/beta-catenin signaling: phosphorylation regulation of Wnt receptor-Axin inter
    Xi He; Fiscal Year: 2013
    ..receptors, and the other is a single-pass transmembrane receptor of the LDL receptor related protein (LRP) family, LRP5 or LRP6...
  51. The effects of acute binge alcohol exposure on the canonical Wnt signaling pathwa
    KRISTEN LEIGH LAUING; Fiscal Year: 2011
    ..Key proteins of the canonical Wnt signaling pathway, Beta-catenin and Lrp5, demonstrated decreased mRNA levels in a study performed in our lab...
  52. Xi He; Fiscal Year: 2016
    ..while the other is a single transmembrane receptor belonging to the LDL receptor related protein (LRP) family, LRP5 or LRP6...
  53. Lrp5-dependent regulation of bone mass accrual by gut-derived serotonin
    Gerard Karsenty; Fiscal Year: 2013
    Project Summary Lrp5 is a positive regulator of bone formation in vertebrates. It is generally assumed that it fulfills this function as a coreceptor for Wnt proteins...
  54. Irina Artsimovitch; Fiscal Year: 2016
    ..RfaH action depends on a DNA sequence called ops that mediates RfaH recruitment to RNA polymerase during elongation...
  55. Wnt signaling and hematopoietic stem cells
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..of apolipoprotein E as ND scaffold protein will affect Wnt3a-ND activity through binding to the Wnt co-receptor LRP5 will be tested...
  56. MAX TISCHFIELD; Fiscal Year: 2014
    ..development in the vertebrate retina-the activation of the endothelial cell receptor Frizzled4 (Fz4) and coreceptor Lrp5 by the paracrine action of the Muller glia-derived ligand Norrin-and described how perturbations in this pathway ..
  57. Xu Cao; Fiscal Year: 2014
    ..BMP ligand-receptor binding and signaling is inhibited by antagonists and extracellular membrane proteins, such as LRP5/6, sclerostin and noggin which bind to BMPs and prevent them from gaining access to their receptors Our data ..
  58. Cara J Gottardi; Fiscal Year: 2014
    ..for Wnt/b-catenin signaling in the bleomycin model for lung fibrosis, using mouse models that manifest attenuated (LRP5-/-) or enhanced (AXIN2-/-) b-catenin signaling (Aim 1)...
  59. MICHAEL CYRUS MAHER; Fiscal Year: 2014
    ..We expect this to provide useful information about how HCV co-ops host cell machinery...
  60. Relating multiple dimensions of stress to CVD risk in Filipino adults collaborati
    Linda S Adair; Fiscal Year: 2010
    ..we propose to strengthen the ongoing research collaboration between the Office of Population Studies Foundation (OPS) at the University of San Carlos in Cebu, Philippines and the University of North Carolina at Chapel and to develop ..
  61. CHRISTINA MARIE JACOBSEN; Fiscal Year: 2016
    ..experiments, I have found that enhancing bone anabolism via the low density lipoprotein receptor related-protein 5 (LRP5) signaling pathway leads to significant increases in bone mass and bone strength in two mouse models of OI...
  62. KENAN CHRISTOPHER GARCIA; Fiscal Year: 2014
    ..Wnt binding to Frizzled, which has structural similarities to G-protein coupled receptors, and the co-receptors Lrp5/6, is indispensable for Wnt/-catenin signaling, and is counterbalanced by a variety of endogenous antagonists...
  63. DXA: HEALTH BELIEFS & OSTEOPOROSIS PREVENTION BEHAVIORS
    Carol Sedlak; Fiscal Year: 2002
    ..The theory base is the Health Belief Model (HBM)...