LRCH1

Summary

Gene Symbol: LRCH1
Description: leucine rich repeats and calponin homology domain containing 1
Alias: CHDC1, NP81, leucine-rich repeat and calponin homology domain-containing protein 1, leucine-rich repeats and calponin homology (CH) domain containing 1, neuronal protein 81
Species: human

Top Publications

  1. ncbi Changes in neuronal protein expression in LP-BM5-infected mice
    Kanako Takahashi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Japan
    Neurosci Lett 422:114-8. 2007
  2. ncbi Fluctuations of hippocampal neuronal protein levels over the estrous cycle in the rat
    Wei Fei Diao
    Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18, A 1090 Vienna, Austria
    Neurochem Int 52:1002-11. 2008
  3. pmc Co-expression of Argonaute2 Enhances Short Hairpin RNA-induced RNA Interference in Xenopus CNS Neurons In Vivo
    Chih Ming Chen
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory Cold Spring Harbor, NY, USA
    Front Neurosci 3:63. 2009
  4. ncbi Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
  5. ncbi New gene associations in osteoarthritis: what do they provide, and where are we going?
    Shiro Ikegawa
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, Tokyo, Japan
    Curr Opin Rheumatol 19:429-34. 2007
  6. ncbi Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
    Qing Jiang
    Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, China
    J Hum Genet 53:42-7. 2008
  7. ncbi Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep
    Roberto Chiocchetti
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy
    Cell Tissue Res 318:289-303. 2004
  8. ncbi Structural differences of the enteric nervous system in the cattle forestomach revealed by whole mount immunohistochemistry
    A F Teixeira
    Institute of Biology, Federal University of Pelotas, Brazil
    Ann Anat 180:393-400. 1998
  9. ncbi Carnosine-like immunoreactivity in neurons of the brain of an advanced teleost, the gray mullet (Chelon labrosus, Risso)
    Iván Lamas
    Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruna, 15007 A Coruña, Spain
    Brain Res 1149:87-100. 2007
  10. doi Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation
    D Wattchow
    Department of Surgery, Flinders University of South Australia, Beford Park, South Australia, Australia
    Neurogastroenterol Motil 20:1298-305. 2008

Research Grants

  1. REGULATION OF DYNAMIN I IN SYNAPTIC TRANSMISSION
    Joseph Albanesi; Fiscal Year: 2001
  2. KENDRA BENCE; Fiscal Year: 2015
  3. Intra- and Inter-Neuronal Viral Trafficking
    Glenn F Rall; Fiscal Year: 2012
  4. The Neuronal alpha-bungarotoxin Binding Site
    WILLIAM NATHAN GREEN; Fiscal Year: 2012
  5. Daniel M Raben; Fiscal Year: 2016
  6. Gabriela Chiosis; Fiscal Year: 2014
  7. MOJGAN HOSSEINI NAGHAVI; Fiscal Year: 2016
  8. Neuroprotective microRNA pathways
    Scott E Counts; Fiscal Year: 2013
  9. Beclin 1 Neurodegeneration and Alzheimer's Disease
    Tony Wyss-Coray; Fiscal Year: 2013
  10. CHARLES BIX SHOEMAKER; Fiscal Year: 2015

Detail Information

Publications222 found, 100 shown here

  1. ncbi Changes in neuronal protein expression in LP-BM5-infected mice
    Kanako Takahashi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Japan
    Neurosci Lett 422:114-8. 2007
    ..We verified the expression levels of these proteins by Western blot. Analysis of these 35 spots could provide insight into mechanisms of dysmnesia in the MAIDS model of HIV-related neuronal dysfunction...
  2. ncbi Fluctuations of hippocampal neuronal protein levels over the estrous cycle in the rat
    Wei Fei Diao
    Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18, A 1090 Vienna, Austria
    Neurochem Int 52:1002-11. 2008
    ....
  3. pmc Co-expression of Argonaute2 Enhances Short Hairpin RNA-induced RNA Interference in Xenopus CNS Neurons In Vivo
    Chih Ming Chen
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory Cold Spring Harbor, NY, USA
    Front Neurosci 3:63. 2009
    ..This should extend the application of RNAi to study gene function of intact brain circuits...
  4. ncbi Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
    ..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee...
  5. ncbi New gene associations in osteoarthritis: what do they provide, and where are we going?
    Shiro Ikegawa
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, Tokyo, Japan
    Curr Opin Rheumatol 19:429-34. 2007
    ..This review summarizes recent advances and emerging challenges in osteoarthritis association studies...
  6. ncbi Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
    Qing Jiang
    Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, China
    J Hum Genet 53:42-7. 2008
    ..OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the results are inconsistent...
  7. ncbi Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep
    Roberto Chiocchetti
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy
    Cell Tissue Res 318:289-303. 2004
    ..Thus, CALB is a marker of most Dogiel type II neurons in the sheep but is not confined to Dogiel II neurons. CGRP is a more selective marker of Dogiel type II neurons, being only found in this neuron type...
  8. ncbi Structural differences of the enteric nervous system in the cattle forestomach revealed by whole mount immunohistochemistry
    A F Teixeira
    Institute of Biology, Federal University of Pelotas, Brazil
    Ann Anat 180:393-400. 1998
    ....
  9. ncbi Carnosine-like immunoreactivity in neurons of the brain of an advanced teleost, the gray mullet (Chelon labrosus, Risso)
    Iván Lamas
    Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruna, 15007 A Coruña, Spain
    Brain Res 1149:87-100. 2007
    ..Carnosine-like immunoreactive cells in mullet brain seem to be specific types of neurons, in line with previous results in a urodele but at variance with previous results in mammals, reptiles and anurans...
  10. doi Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation
    D Wattchow
    Department of Surgery, Flinders University of South Australia, Beford Park, South Australia, Australia
    Neurogastroenterol Motil 20:1298-305. 2008
    ..Accurate quantification of neuronal populations in whole mounts of human colon reveals inter-regional differences in innervation and marked changes in innervation in cases of very severe constipation...
  11. doi Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair
    Thomas J Nelson
    Blanchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive, Rockville, Maryland 20850 USA
    Eur J Pharmacol 585:76-87. 2008
    ....
  12. ncbi Quantitative estimation of putative primary afferent neurons in the myenteric plexus of human small intestine
    Simone Weidmann
    Institute of Anatomy I, University of Erlangen Nuremberg, Krankenhausstr 9, 91054, Erlangen, Germany
    Histochem Cell Biol 128:399-407. 2007
    ..We suggest that the proportion of myenteric type II neurons in the human small intestine is related to the proportion of CALR/SOM-co-reactive neurons and may be near to one tenth of the total myenteric neuronal population...
  13. ncbi An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders
    Dawn L Thiselton
    Department of Molecular Genetics, Institute of Ophthalmology, University College, London, EC1V 9EL, UK
    Genomics 79:560-72. 2002
    ..3-Xp11.23 interval and provides a powerful integrated resource for functional characterization of this clonally unstable, yet gene-rich and clinically significant region of proximal Xp...
  14. ncbi Aberrant neuronal and mitochondrial proteins in hippocampus of transgenic mice overexpressing human Cu/Zn superoxide dismutase 1
    Joo Ho Shin
    Department of Pediatrics, University of Vienna, A 1090, Vienna, Austria
    Free Radic Biol Med 37:643-53. 2004
    ..This observation is of relevance to understanding brain deficits in Down syndrome, as SOD1 is encoded on chromosome 21...
  15. ncbi Skin keratinocytes pre-treated with embryonic stem cell-conditioned medium or BMP4 can be directed to an alternative cell lineage
    K L Grinnell
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Cell Prolif 40:685-705. 2007
    ..In this study, we have investigated whether secreted factors from embryonic stem cells (ESCs) could reprogramme keratinocytes and increase their potential to be directed into alternative cell lineages...
  16. pmc Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
    F Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11062-8. 2001
    ..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels...
  17. ncbi Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction
    Sukmook Lee
    Division of Molecular and Life Sciences, Pohang University of Science and Technology POSTECH, Pohang 790 784, Republic of Korea
    J Biol Chem 277:6542-9. 2002
    ..Taken together, our results indicate that CRMP-2 may interact directly with and inhibit neuronal PLD(2), suggesting that this inhibitory mode of regulation may play a role in neuronal pathfinding during the developmental stage...
  18. ncbi LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex
    Laura Carim-Todd
    Programme of Bioinformatics and Genomics, Centre de Regulacio Genomica CRG, Passeig Maritim 37 49, 08003 Barcelona, Spain
    Eur J Neurosci 18:3167-82. 2003
    ....
  19. ncbi S-100B release during carotid endarterectomy under local anesthesia
    Marko Aleksic
    Division of Vascular Surgery, Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Vasc Surg 21:571-5. 2007
    ..During uncomplicated CEA under local anesthesia, there is no relevant increase of S-100B. These results are different from those reported when CEA is done under general anesthesia...
  20. ncbi A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones
    A S Parent
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    J Neuroendocrinol 19:847-59. 2007
    ....
  21. doi Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
    Inmaculada Cuchillo-Ibanez
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry P037, De Crespigny Park, SE5 8AF London, UK
    FASEB J 22:3186-95. 2008
    ..Hyperphosphorylated tau in Alzheimer's disease appearing first in distal portions of axons may result from aberrant axonal transport of phosphorylated tau reported here...
  22. ncbi The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event
    H Min
    Molecular Biology Institute, University of California at Los Angeles 90024 1662, USA
    Genes Dev 9:2659-71. 1995
    ..The assembly of regulatory complexes from both constitutive and specific proteins is likely to be a general feature of tissue-specific splicing regulation...
  23. ncbi Evidence that syntaxin 1A is involved in storage in the secretory pathway
    M A Bittner
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 271:11214-21. 1996
    ..The present experiments indicate that syntaxin 1A enables the storage of vesicles which would otherwise be immediately released...
  24. ncbi The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence
    D Grabs
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 272:13419-25. 1997
    ..Our data demonstrate that the long proline-rich stretch present in dynamin I contained multiple SH3 domain binding sites that recognize interacting proteins with high specificity...
  25. ncbi Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons
    D Meyer
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:35113-8. 1999
    ..The interaction of JIP-1 with rhoGEF and its subcellular localization suggests that JIP-1 may function to specifically localize a signaling complex in neuronal cells...
  26. ncbi Expression of neurogranin and neuromodulin is affected in the striatum of vitamin A-deprived rats
    M Husson
    Unité de Nutrition et Signalisation Cellulaire EA MENRT USC INRA ISTAB, Universite Bordeaux 1, Avenue des Facultes, Talence Cedex 33405, France
    Brain Res Mol Brain Res 123:7-17. 2004
    ....
  27. ncbi Molecular mediators of hypoxic-ischemic injury and implications for epilepsy in the developing brain
    Mir Ahamed Hossain
    Department of Neurology, The Johns Hopkins University School of Medicine and The Kennedy Krieger Research Institute, Baltimore, MD 21205, USA
    Epilepsy Behav 7:204-13. 2005
    ....
  28. ncbi RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor
    Bhagavathi A Narayanan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mol Cancer Ther 5:1117-25. 2006
    ..Finally, our findings provide evidence of COX-2-independent targets promoting cell growth arrest and differentiation in cells lacking COX-2 expression at the mRNA level...
  29. ncbi Batten's disease: clues to neuronal protein catabolism in lysosomes
    G Dawson
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Neurosci Res 60:133-40. 2000
    ..We conclude that the 8 genes probably code for proteins which facilitate the degradation of post-translationally modified proteins in lysosomes, suggesting that the turnover of these proteins is highest in cortical neurons...
  30. ncbi Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  31. ncbi Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33
    Y Goshima
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 376:509-14. 1995
    ..CRMP-62 appears to be an intracellular component of a signalling cascade initiated by an unidentified transmembrane collapsin-binding protein...
  32. ncbi Behavioral characterization in a comprehensive mouse test battery reveals motor and sensory impairments in growth-associated protein-43 null mutant mice
    G A Metz
    Canadian Center for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Neuroscience 129:563-74. 2004
    ..The results also show that the comprehensive test battery used in the present study represents a sensitive approach to assess the functional integrity of ascending and descending pathways in genetically manipulated mice...
  33. ncbi Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 15:337-46. 2006
    ..Our results, for the first time, link PPT1 deficiency with the activation of UPR, apoptosis and neurodegeneration in INCL and identify potential targets for therapeutic intervention in this uniformly fatal disease...
  34. doi Epigenetic control of translation regulation: alterations in histone H3 lysine 9 post-translation modifications are correlated with the expression of the translation initiation factor 2B (Eif2b5) during thermal control establishment
    Tatiana Kisliouk
    Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
    Dev Neurobiol 70:100-13. 2010
    ..These data suggest a role for dynamic H3K9 post-translational modifications in global translation regulation during the thermal control establishment...
  35. pmc Axonal inclusions in spinocerebellar ataxia type 3
    Kay Seidel
    Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, 9713 RB Groningen, The Netherlands
    Acta Neuropathol 120:449-60. 2010
    ....
  36. ncbi Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (C-tau)
    F P Zemlan
    Department of Psychiatry, College of Medicine, 231 Sabin Avenue, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuroscience 121:399-409. 2003
    ..These data suggest that C-tau proteolysis may prove a reliable species independent biomarker of neuronal degeneration regardless of source of injury...
  37. ncbi M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3
    Vladislav V Zakharov
    Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute of Russian Academy of Sciences, Gatchina, Leningrad District, Russia
    J Neurochem 101:1539-51. 2007
    ..We suggest that GAP-43-3 and another (N-terminal) GAP-43 fragment produced by m-calpain participate in modulation of neuronal response to repulsive and apoptotic signals...
  38. ncbi TTX-sensitive and TTX-insensitive control of spontaneous gut motility in the developing zebrafish (Danio rerio) larvae
    Anna Holmberg
    Department of Zoophysiology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Exp Biol 210:1084-91. 2007
    ..However, later in development, nerves have an increasingly important role as modulators of intestinal activity...
  39. pmc Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues
    Fang qiong Li
    School of Pharmacy and Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China
    J Neurosci 30:10351-9. 2010
    ..Results indicate that basolateral amygdala Cdk5 activity is critical for consolidation and reconsolidation of the memories of cocaine-associated environmental cues...
  40. ncbi Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1
    L C Hsieh-Wilson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4365-73. 1999
    ..These studies support the notion that spinophilin functions in vivo as a neuronal PP1 targeting subunit by directing the enzyme to postsynaptic densities and regulating its activity toward physiological substrates...
  41. ncbi Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse
    N Arimura
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    J Biol Chem 275:23973-80. 2000
    ..These results demonstrate the existence of Rho-kinase-dependent and -independent pathways for growth cone collapse and suggest that CRMP-2 phosphorylation by Rho-kinase is involved in the former pathway...
  42. ncbi Involvement of cAMP- and Ca(2+)/calmodulin-dependent neuronal protein phosphorylation in mechanisms underlying genetic predisposition to audiogenic seizures in rats
    S Yechikhov
    Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Pushchino, Moscow, Moscow Region, 142292, Russia
    Epilepsy Res 46:15-25. 2001
    ..The present results indicate that modification of 270, 58, 54, and 42 kDa proteins phosphorylation as well as altered CAMKII and PKA activities might be involved in mechanisms of genetic predisposition to audiogenic seizures...
  43. ncbi Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase
    C Hall
    Department of Neurochemistry, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N IPJ, United Kingdom
    J Biol Chem 276:43482-6. 2001
    ..Thus Crmp-2, regulated by Rho kinase, promotes outgrowth and collapse in response to active Rho and Rac, respectively, reversing their usual morphological effects and providing a mechanism for dynamic modulation of growth cone guidance...
  44. ncbi Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus
    Xiaonan Zhu
    Department of Nutrition, McGavran Greenberg Building, CB 7461, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Brain Res Dev Brain Res 149:121-9. 2004
    ..This is the first report of altered brain development in Pemt-/- mice...
  45. ncbi The role of alpha-synuclein in neurodegenerative diseases
    M Catherine Bennett
    Blanchette Rockefeller Neurosciences Institute, Rockville, MD, USA
    Pharmacol Ther 105:311-31. 2005
    ..Various mechanisms for in vitro and in vivo alpha-synuclein aggregation and neurotoxicity are summarized, and their relevance to neuropathology is explored...
  46. ncbi The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression
    Corinna Giorgi
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    Cell 130:179-91. 2007
    ....
  47. pmc The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues
    J Dalmau
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Am J Pathol 141:881-6. 1992
    ..In lung tumors, the Hu antigen is restricted in its expression to all small cell carcinomas. A few other neuroendocrine-related tumors, especially neuroblastomas (50%), also express the antigen...
  48. ncbi MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain
    J A Hammarback
    Cell Biology Group, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    Neuron 7:129-39. 1991
    ..Together these data indicate that the heavy chain and light chain 1 are produced by proteolytic processing of a MAP1B polyprotein and form a complex microtubule-binding domain...
  49. ncbi The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals
    C Reichmuth
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Wurzburg, Germany
    Brain Res Mol Brain Res 32:45-54. 1995
    ..The sap47 gene is located in 89A8-B3 on chromosome 3R and codes for two almost identical inferred polypeptides of 347 and 351 amino acids with no significant sequence homology to known proteins...
  50. pmc The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein
    S Goetinck
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:79-93. 1994
    ..Studies of the UNC-87 protein in other muscle mutants suggest that the unc-87 gene product associates with thin filaments, in a manner that does not depend on the presence of the thin filament protein tropomyosin...
  51. ncbi Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization
    J Han
    Laboratory of Medical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
    Genomics 36:189-91. 1996
    ..The different chromosomal locations of these homologous genes underscore their distinct identities...
  52. pmc Bet1p activates the v-SNARE Bos1p
    S Stone
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Mol Biol Cell 8:1175-81. 1997
    ..Genetic studies suggest that the interactions of Bet1p with Bos1p are regulated by the small GTP-binding protein Ypt1p...
  53. ncbi Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    A Yamamoto
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:57-66. 2000
    ..We thus demonstrate that a continuous influx of the mutant protein is required to maintain inclusions and symptoms, raising the possibility that HD may be reversible...
  54. pmc Limbic encephalitis and antibodies to Ma2: a paraneoplastic presentation of breast cancer
    I Sutton
    Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Neurol Neurosurg Psychiatry 69:266-8. 2000
    ..This report highlights the importance of testing for paraneoplastic antineuronal antibodies in cases of unexplained limbic encephalitis and suggests screening for breast cancer in women with antibodies predominantly directed to Ma2...
  55. pmc Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes
    T Mengesdorf
    Department of Experimental Neurology, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931 Cologne, Germany
    Biochem J 356:805-12. 2001
    ....
  56. pmc Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD
    Pascal Steiner
    Faculté des Sciences de la Vie, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    J Cell Biol 157:1197-209. 2002
    ..In summary, NEEP21 is a neuronal protein that is localized to the early endosomal pathway and is necessary for correct receptor recycling in neurons...
  57. ncbi Increased resistance to nitric oxide cytotoxicity associated with differentiation of neuroblastoma-glioma hybrid (NG108-15) cells
    Koichi Kawahara
    Laboratoire of Biomedical Control, Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan
    Free Radic Res 36:545-54. 2002
    ..The present study suggested that the activity of SOD increased in parallel with the activity of NOS associated with differentiation and was crucial for the acquired resistance to NO toxicity in differentiated cells...
  58. ncbi Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C
    Ana Olariu
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Brain Res 957:278-86. 2002
    ..Our data indicate that chronic accumulation of beta-amyloid (1-40) into the rat brain reduced activation of PKC, effect that would substantially contribute to the memory deficit found in these animals...
  59. ncbi Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein
    Felix Mor
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 170:628-34. 2003
    ....
  60. pmc GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity
    Marco Caprini
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, 03202 Alicante, Spain
    EMBO J 22:3004-14. 2003
    ....
  61. ncbi Triiodothyronine administration reverses vitamin A deficiency-related hypo-expression of retinoic acid and triiodothyronine nuclear receptors and of neurogranin in rat brain
    Marianne Husson
    Unité de Nutrition et Signalisation Cellulaire E A MENRT USC INRA ISTAB, Universite Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Br J Nutr 90:191-8. 2003
    ..This seems of crucial importance since the down regulation of RC3 observed in the depleted rats was corrected only by T3...
  62. ncbi Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain
    Iris Depaz
    Department of Biochemistry and Molecular Biology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Brisbane, Australia
    Alcohol Clin Exp Res 27:1481-8. 2003
    ..hNP22 has high homology with a rat protein (rNP22). These proteins also share homology with a number of cytoskeleton-interacting proteins...
  63. ncbi BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage
    Yassemi Koutmani
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 115 21, Greece
    Eur J Neurosci 20:2509-23. 2004
    ..Our data show an interesting correlation between BM88 expression and the progression of progenitor cells towards neuronal differentiation during the neurogenic interval...
  64. ncbi Specific proteolysis of neuronal protein GAP-43 by calpain: characterization, regulation, and physiological role
    V V Zakharov
    Molecular and Radiation Biophysics Division, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Leningrad Region, 188300, Russia
    Biochemistry (Mosc) 70:897-907. 2005
    ....
  65. pmc Crystallization and preliminary X-ray diffraction analysis of calexcitin from Loligo pealei: a neuronal protein implicated in learning and memory
    G D E Beaven
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:879-81. 2005
    ..8 A suggest that the crystals contain two monomers per asymmetric unit and have a solvent content of 49%. This crystal form diffracts X-rays to at least 1.8 A resolution and yields data of high quality using synchrotron radiation...
  66. ncbi BM88 is a dual function molecule inducing cell cycle exit and neuronal differentiation of neuroblastoma cells via cyclin D1 down-regulation and retinoblastoma protein hypophosphorylation
    Niki Georgopoulou
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, 115 21 Athens, Greece
    J Biol Chem 281:33606-20. 2006
    ....
  67. pmc Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:12700-7. 2006
    ..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear...
  68. ncbi Greater hippocampal neuronal recruitment in food-storing than in non-food-storing birds
    Jennifer S Hoshooley
    Program in Neuroscience, Department of Psychology, University of Western Ontario, London, Ontario, Canada, N6A 5C2
    Dev Neurobiol 67:406-14. 2007
    ..Enhanced neuronal recruitment in the hippocampus of food-storing chickadees suggests a degree of neurogenic specialization that may be associated with the spatial memory requirements of food-storing behavior...
  69. ncbi UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants
    Maelle Jospin
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Curr Biol 17:1595-600. 2007
    ..These data suggest that activation of the NCA ion channel in synaptojanin mutants leads to defects in recycling of synaptic vesicles...
  70. ncbi Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease
    Seung Jae Lee
    Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea
    J Mol Neurosci 34:17-22. 2008
    ....
  71. pmc Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
    Rujun Kang
    Department of Psychiatry, Brain Research Centre, University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada
    Nature 456:904-9. 2008
    ....
  72. doi Immunochemical and molecular characterization of GBC4 as a tanycyte-like cell line derived from grouper brain
    Chiu Ming Wen
    Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan
    Comp Biochem Physiol A Mol Integr Physiol 153:191-201. 2009
    ..Because GBC4 expresses several neural-specific genes, this line will be useful for studies on gene expression/regulation and neural development...
  73. doi Fall in density, but not number of myenteric neurons and circular muscle nerve fibres in guinea-pig colon with ageing
    C J Peck
    F D Stephens Surgical Research Laboratory, Murdoch Childrens Research Institute, Melbourne, Australia
    Neurogastroenterol Motil 21:1075-e90. 2009
    ..The percentage area of motor nerve fibres in the circular muscle decreased with no change in total volume of nerve fibres...
  74. doi Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219
    Richard Lee Clough
    Division of Basic Neuroscience, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    J Neurochem 110:1479-90. 2009
    ..Targeting ZSCAN21 or other TFs controlling SNCA transcriptional activity may provide novel therapeutic avenues not only for Parkinson's disease but also for other synucleopathies...
  75. pmc Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis
    Ekaterina Posokhova
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Proteome Res 9:1510-21. 2010
    ..We propose this application to be a useful tool for studying the dynamics of protein assemblies in complex models, such as signaling in the mammalian nervous system...
  76. pmc Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P
    R Lane Coffee
    Department of Biological Sciences, Vanderbilt Brain Institute, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235 1634, USA
    Dis Model Mech 3:471-85. 2010
    ..We conclude that FMR1 has a neural-specific function that is distinct from its paralogs, and that the unique FMR1 function is responsible for regulating neuronal protein expression and synaptic connectivity...
  77. ncbi Geriatric medicine, Japanese Alzheimer's disease neuroimaging initiative and biomarker development
    Hiroyuki Arai
    Department of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging, and Cancer, Tohoku University FO11547 1
    Tohoku J Exp Med 221:87-95. 2010
    ..Imaging of AD pathology not only acts as a reliable biomarker with which to assay curative drug development by novel pharmaceutical companies, but it also helps health promotion toward AD prevention...
  78. pmc Chemomechanical regulation of SNARE proteins studied with molecular dynamics simulations
    Lars V Bock
    Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Biophys J 99:1221-30. 2010
    ..Removal of the linker induced different conformational changes than oxidation. The simulations suggest that oxidation of the cysteines leads to a dysfunctional SNARE complex, thus downregulating NT release during oxidative stress...
  79. pmc LRCH proteins: a novel family of cytoskeletal regulators
    Hélène Foussard
    Université de Toulouse UPS, Centre de Biologie du Developpement, Toulouse, France
    PLoS ONE 5:e12257. 2010
    ..Here we report the characterization of a novel family of evolutionary conserved proteins, which display specific features of cytoskeletal scaffolding proteins, referred to as LRCHs...
  80. pmc Polyadenylated mRNA staining reveals distinct neuronal phenotypes following endothelin 1, focal brain ischemia, and global brain ischemia/ reperfusion
    Jill T Jamison
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurol Res 33:145-61. 2011
    ..An important marker of post-ischemic stress responses is inhibition of neuronal protein synthesis, a morphological correlate of which is the compartmentalization of mRNA away from ribosomes in the form of cytoplasmic mRNA granules...
  81. pmc Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells
    Austin Cape
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Mol Life Sci 69:1305-17. 2012
    ..These studies suggest that Hap1 is important for insulin release from β-cells via dephosphorylation that can regulate its intracellular trafficking function...
  82. pmc Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease
    Eugenia Yakunin
    Department of Biochemistry and Molecular Biology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Brain Pathol 22:280-94. 2012
    ..Our results suggest a role for activated RXR/PPARγ 2, obtained by elevated brain PUFA levels, in α-Syn neuropathology...
  83. doi Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1)
    Claudia Borrmann
    Institut fur Neurobiochemie, Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Magdeburg, Germany
    Cell Tissue Res 346:89-98. 2011
    ....
  84. pmc Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway
    Ji Song Guan
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e25735. 2011
    ..Collectively, our results demonstrate a critical role for Cdk5 in the regulation of cAMP-mediated hippocampal functions essential for synaptic plasticity and memory formation...
  85. doi Oestrogens as modulators of neuronal signalosomes and brain lipid homeostasis related to protection against neurodegeneration
    R Marin
    Department of Physiology, Laboratory of Cellular Neurobiology, University of La Laguna, La Laguna, Tenerife, Spain
    J Neuroendocrinol 25:1104-15. 2013
    ....
  86. doi Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors
    Masaya Nagaishi
    Department of Neurosurgery, Dokkyo Medical University Koshigaya Hospital, 2 1 50 Minami Koshigaya, Koshigaya shi, Saitama, 343 8555
    Neuropathology 35:561-8. 2015
    ..These results supported the presumption that MVNT is a distinct histopathological entity. ..
  87. doi Targeting α-synuclein as a therapeutic strategy for Parkinson's disease
    Nada B Lawand
    a 1 American University of Beirut, Department of Anatomy, Cell Biology and Physiology Sciences, Beirut, Lebanon
    Expert Opin Ther Targets 19:1351-60. 2015
    ..Cases of PD have increased tremendously over the past decade necessitating the identification of new therapeutic targets to reduce patient morbidity and to improve PD patients' quality of life...
  88. doi New insights into cellular α-synuclein homeostasis in health and disease
    Ulf Dettmer
    Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Neurobiol 36:15-22. 2016
    ..Here, we review new insights into how neuronal αSyn homeostasis may be maintained under physiological conditions but perturbed by pathological factors. ..
  89. pmc The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation
    Ognian C Ikonomov
    From the Departments of Physiology
    J Biol Chem 290:28515-29. 2015
    ....
  90. ncbi Subcellular Parkinson's Disease-Specific Alpha-Synuclein Species Show Altered Behavior in Neurodegeneration
    Rashed Abdullah
    Department of Biological Sciences, St John s University, New York, NY, 11349, USA
    Mol Neurobiol . 2016
    ..The characterization of subcellular-specific α-synuclein features in neurodegeneration will allow for the identification of neurotoxic α-synuclein species, which represent prime targets to reduce α-synuclein pathogenicity...
  91. doi Mechanism of α-synuclein translocation through a VDAC nanopore revealed by energy landscape modeling of escape time distributions
    David P Hoogerheide
    Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Nanoscale 9:183-192. 2017
    ..Time-resolved measurements of the electrical properties of VDAC occupied by α-synuclein reveal distinct effects of the motion of the junction separating the differently charged regions of the polymer...
  92. doi Cell Biology and Pathophysiology of α-Synuclein
    Jacqueline Burré
    Appel Institute for Alzheimer s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10021
    Cold Spring Harb Perspect Med . 2017
    ....
  93. ncbi A GAP-43-like protein in cat visual cortex
    H McIntosh
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110
    Vis Neurosci 2:583-91. 1989
    ..We conclude that our purified protein is cat GAP-43. Immunoblots with an antibody prepared against rat GAP-43 suggested that the concentration of GAP-43 in the visual cortex declines with age...
  94. pmc Characterization of calretinin I-II as an EF-hand, Ca2+, H+-sensing domain
    Malgorzata Palczewska
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    Protein Sci 14:1879-87. 2005
    ..CR may sense and respond to calcium, proton, and other signals, contributing to conflicting data on the proteins role as a calcium sensor or calcium buffer...
  95. ncbi Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology
    S Mondragón-Rodríguez
    Department of Cell Biology, CINVESTAV IPN, Mexico City, Mexico
    Neuropathol Appl Neurobiol 34:62-75. 2008
    ..Despite this consistency with AD, we found a major distinction, namely that PBs lack beta-sheet conformation. We propose a scheme of early tau processing in these structures, similar to neurofibrillary tangles of AD...
  96. doi Transition of tau protein from disordered to misordered in Alzheimer's disease
    Branislav Kovacech
    Institute of Neuroimmunology, AD Centre, Slovak Academy of Sciences, Bratislava, Slovakia
    Neurodegener Dis 7:24-7. 2010
    ..We propose the term 'misdisordered' for this distinct conformational state of tau, which is the first step in the transition of tau from a soluble disordered protein to its insoluble, misordered aggregated form...
  97. pmc Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities
    John Paul Silva
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 108:12113-8. 2011
    ..Thus, LPH1 and Lasso can form transsynaptic complexes capable of inducing presynaptic Ca(2+) signals, which might affect synaptic functions...
  98. doi Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development
    Takayoshi Bando
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Neurosci Lett 548:73-8. 2013
    ....
  99. ncbi Amino acid sequence of a unique neuronal protein: rat olfactory marker protein
    W Sydor
    Arch Biochem Biophys 249:351-62. 1986
    ....
  100. ncbi A novel receptor-type protein tyrosine phosphatase is expressed during neurogenesis in the olfactory neuroepithelium
    K M Walton
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
    Neuron 11:387-400. 1993
    ..In the olfactory neuroepithelium, PTP NE-3 expression is restricted to neurons and describes a novel pattern of expression with a high level in the immature neurons and a lower level in mature olfactory sensory neurons...
  101. ncbi CNS gene encoding astrotactin, which supports neuronal migration along glial fibers
    C Zheng
    Rockefeller University, New York, NY 10021 6399, USA
    Science 272:417-9. 1996
    ..Transfection of astrotactin complementary DNA into 3T3 cells indicated that astrotactin acts as a ligand for neuron-glia binding during neuronal migration...

Research Grants67

  1. REGULATION OF DYNAMIN I IN SYNAPTIC TRANSMISSION
    Joseph Albanesi; Fiscal Year: 2001
    ..The structural and kinetic basis of GTPase stimulation by phosphoinositides will be examined. And, as above, the in vivo significance of phosphoinositide binding will be determined by homologous recombination techniques in mice. ..
  2. KENDRA BENCE; Fiscal Year: 2015
    ..This combination of genetic, biochemical, and electrophysiological techniques will provide essential information about the cellular mechanism of PTP action in hypothalamic neurons as relates to energy balance. ..
  3. Intra- and Inter-Neuronal Viral Trafficking
    Glenn F Rall; Fiscal Year: 2012
    ..Successful completion of the proposed aims will provide the foundation for the development of treatments to prevent or reverse the life-threatening consequences of chronic CNS infections caused by viruses. ..
  4. The Neuronal alpha-bungarotoxin Binding Site
    WILLIAM NATHAN GREEN; Fiscal Year: 2012
    ..As the site where nicotine binds in the brain, these receptors are responsible for nicotine addiction and also play a role in neurodegenerative and psychiatric diseases such as Alzheimers disease and schizophrenia. ..
  5. Daniel M Raben; Fiscal Year: 2016
    ..These studies will forge new mechanistic and physiological links between the regulation and function of neuronal DGK- theta. ..
  6. Gabriela Chiosis; Fiscal Year: 2014
    ..Second, its benefit comes from induction of Hsp70, a chaperone able of redirecting neuronal aggregate formation, and of protective potential against both Abeta and tau aggregate toxicity. ..
  7. MOJGAN HOSSEINI NAGHAVI; Fiscal Year: 2016
    ..As such, these studies are also likely to contribute to our broader understanding of the control of nuclear transport and architecture. ..
  8. Neuroprotective microRNA pathways
    Scott E Counts; Fiscal Year: 2013
    ..These studies may reveal new insights into gene regulation pathways leading to innovative therapeutic avenues for modifying AD progression. ..
  9. Beclin 1 Neurodegeneration and Alzheimer's Disease
    Tony Wyss-Coray; Fiscal Year: 2013
    ..If we inhibit this protein degradation process in AD mice they develop more disease. We propose to study this process to try to reduce disease in mice and possibly in AD. ..
  10. CHARLES BIX SHOEMAKER; Fiscal Year: 2015
    ..In contrast, the innovative new platform for biomolecule therapeutics that we propose to develop has the potential to quickly lead to commercially viable antidotes for all BoNT serotypes. ..
  11. Russell L Margolis; Fiscal Year: 2014
    ..abstract_text> ..
  12. Studies of mouse kappa opioid receptor gene regulation
    Li na Wei; Fiscal Year: 2011
    ....
  13. Davide Comoletti; Fiscal Year: 2015
    ....
  14. Proteomic Assays of Neuronal Protein Palmitoylation
    William N Green; Fiscal Year: 2011
    ....
  15. Molecular Basis of RGS Protein Function in the Striatum
    Kirill A Martemyanov; Fiscal Year: 2011
    ..These studies should provide an understanding of the regulation of signaling in the striatum and generate insights into the molecular mechanisms of G protein signal disruption caused by drug abuse and neurological diseases. ..
  16. Stephen R Salton; Fiscal Year: 2014
    ....
  17. Validation of the use of quantum dot-labeled proteins as biomarkers in vivo
    Christopher S von Bartheld; Fiscal Year: 2011
    ..Prior to their use as biomarkers, validation has to occur in in-vivo model systems, to identify changes in trafficking, kinetics, signaling and receptor binding that may impose inherent limitations and compromise optimal utility. ..
  18. Kirill A Martemyanov; Fiscal Year: 2016
    ..This knowledge will be important for better understanding of how drugs of abuse lead to addiction with the hopes for the future development of therapeutical intervention strategies. ..
  19. Steven M Finkbeiner; Fiscal Year: 2016
    ..The results could help validate the protein dyshomeostasis model of HD and lead to new therapies. ..
  20. Linking network activity and intracellular plasticity mechanisms during sleep-dep
    Sara J Aton; Fiscal Year: 2013
    ..Finally, we will combine these tools to determine for the first time how sleep- associated changes in neuronal activity and neurotransmission impact intracellular processes such as protein translation in neural circuits. ..
  21. Jeffery L Twiss; Fiscal Year: 2016
    ..Finally, we will generate and characterize viral reporter constructs that will enable us to address RNA localization mechanisms in vivo. ..
  22. James A Bibb; Fiscal Year: 2014
    ....
  23. KENNETH ROBERT WILLIAMS; Fiscal Year: 2016
    ....
  24. James A Bibb; Fiscal Year: 2016
    ..This translational research will significantly advance our understanding of the mechanisms of addiction and may contribute to the development of treatments to help addicted individuals recover. ..
  25. Senataxin mutations in familial motor neuron disease (ALS4) and Ataxia (AOA2)
    Gwenn A Garden; Fiscal Year: 2010
    ..Since there is currently no cure or preventive treatment for these conditions, any knowledge gained has the potential to provide future diagnostic and therapeutic interventions for these patients. ..
  26. Mechanisms of Glutamate Receptor Synaptic Clustering
    Dane M Chetkovich; Fiscal Year: 2010
    ....
  27. Sarah Elizabeth Antinone; Fiscal Year: 2014
    ..abstract_text> ..
  28. Regulation of Anatomical Plasticity and Perceptual Learning by NgR1
    Aaron W McGee; Fiscal Year: 2012
    ....
  29. Benjamin B Gelman; Fiscal Year: 2014
    ..The program overall addresses a highly novel mechanism for synaptic dysfunction in HAND and has important implications for the mechanism of interaction between pathological brain aging and HIV/AIDS. ..
  30. Analysis of CHIP, a ubiquitin ligase implicated in neurodegeneration
    KENNETH MATTHEW SCAGLIONE; Fiscal Year: 2010
    ..The current project seeks both to understand how CHIP mediates neuroprotection and to identify compounds that enhance this activity, as they could represent new therapeutic agents for various neurodegenerative diseases. ..
  31. Steven G Boxer; Fiscal Year: 2015
    ..Each Aim targets a significant area of membrane biophysics that integrates innovative molecular assemblies, interfacial fabrication, and advanced imaging methods to address a complex problem of wide interest. ..
  32. Regulated degradation of EF2K: linking neuronal protein synthesis and turnover
    SHARI LENORE WISEMAN; Fiscal Year: 2012
    ..The long-term changes in neural reward circuitry that underlie addiction are thought to engage these molecular processes, and by characterizing them in detail, novel approaches to the treatment of addiction may be developed. ..
  33. Developing Diagnostic Nanobodies Against Aggregated TDP-43 Species
    Michael R Sierks; Fiscal Year: 2013
    ..Here we will develop and test similar reagents for detecting specific forms of TDP-43 that are present in FTD and ALS brain tissue. ..
  34. MOLLIE KATHERINE MEFFERT; Fiscal Year: 2016
    ....
  35. NEURONAL PHOSPHOPROTEINS IN NEUROPSYCHIATRIC DISORDERS
    Jack Grebb; Fiscal Year: 1991
    ..My eventual career goal is to coordinate a schizophrenia research group that would be involved in basic, animal and human research...
  36. MOLECULAR MIMICRY IN IMMUNE MEDIATED NEUROLOGIC DISEASE
    Michael Levin; Fiscal Year: 2001
    ..2. Determine the epitope specificity of HAM/TSP IgG for HTLV-I and the neuronal self protein. 3. Determine the specificity of HAM/TSP IgG for neuronal tissue. ..
  37. GLUCOCORTICOID PROGRAMMING OF THE PITUITARY-ADRENAL AXIS
    Peter Nathanielsz; Fiscal Year: 2005
    ..These studies will improve understanding of how GO affects central features of fetal development. The proposal also involves preparation for follow up studies in nonhuman primates allowed to survive into adult life. ..
  38. Dual Regulation of Brain Dopamine Transporter by Cyclin-Dependent Kinase 5
    David Price; Fiscal Year: 2009
    ..Identification of novel therapeutic targets is contingent upon our understanding of how key molecular players that govern DA neurotransmission (i.e. DAT) are regulated. ..
  39. Optimization of GMAK to treat glioblastoma multiforme
    David Weinstein; Fiscal Year: 2006
    ..The current application describes experiments intended to characterize and optimize the NrS1 fragment for treatment of GBM. [unreadable] [unreadable] [unreadable]..
  40. REDOX METAL IONS AND NEURONAL PROTEIN DEPOSITION
    Craig Atwood; Fiscal Year: 1999
    ..These data will be important in determining the mechanism behind neuronal protein precipitation and may yield insights into how to prevent their deposition in vivo. ..
  41. Tolerance versus tumor immunity in PND
    Robert Darnell; Fiscal Year: 2005
    ..These experiments offer the possibility of developing new cancer treatments and advancing the understanding of autoimmune disease of the nervous system. ..
  42. Assay Development to Identifiy Palmitoylation Inhibitors of Neuronal Proteins
    Maurine Linder; Fiscal Year: 2006
    ....
  43. Identification of Novel Alpha Synuclein Binding Protein
    Michael Shelanski; Fiscal Year: 2007
    ..These studies will enable us to define the range of proteins or agents to be further characterized in in vivo models of Parkinson's disease. ..
  44. Synuclein Binding Proteins: Conformational Regulators
    Brett Lauring; Fiscal Year: 2003
    ..That will allow for screening of proteins and synthetic agents capable of altering synuclein aggregation. These studies will enable us to define the range of proteins or agents to be further characterized in vivo models of PD. ..
  45. METHYL MERCURY AND NEURONAL PROTEIN PHOSPHORYLATION
    Theodore Sarafian; Fiscal Year: 1992
    ..The end result of these studies will be a significantly deeper understanding of protein phosphorylation in the cerebellar granule cell and the aberrations induced by prolonged exposure to low levels of MeHg...
  46. The Roles of a-Synuclein and Parkin in Parkinson Disease
    Michael Schlossmacher; Fiscal Year: 2005
    ..abstract_text> ..
  47. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2007
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  48. Neuronal mRNA transport & local translation analysis
    Jeffery Twiss; Fiscal Year: 2004
    ..g., spinal motor neurons) and whether we can utilize exogenous agents to increase local axonal protein synthesis for expediting axonal regeneration. ..
  49. T CELL RESPONSE TO MEP-REPERTOIRE AND REGULATION
    Eli Sercarz; Fiscal Year: 1999
    ..These studies should help to establish a clearer understanding and potential therapies for this autoimmune disease. ..
  50. UCP5-- Balancing Metabolism and Oxidation in Aging Brain
    LAURA DUGAN; Fiscal Year: 2004
    ....
  51. Affinity Labeling the Dopamine Transporter Active Site
    Roxanne Vaughan; Fiscal Year: 2005
    ..The similarity of DAT to the norepinephrine and serotonin transporters presents the potential for these studies to be applicable to these other transporters. ..
  52. Oxidative metabolites in Alpha-Synucleinopathies
    DARYL BOSCO; Fiscal Year: 2005
    ..These experiments will address a possible role for ROS-oxidized metabolites in sporadic alpha-synucleinopathies. ..
  53. Mass Spectrometry System for High-Throughput Proteomics
    Steven Gross; Fiscal Year: 2004
    ..Award of an integrated 2D chromatography ion trap MS system will extend the scope of services offered by the Weill Cornell MS CORE facility and strengthen the research of a diverse group of biomedical scientists. ..
  54. SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    Roger Nicoll; Fiscal Year: 2001
    ....
  55. Regulation of Ionotropic Glutamate Receptors
    STEVEN TAVALIN; Fiscal Year: 2008
    ..Understanding the basic operation of the AKAP79/150 signaling complex may lead to novel therapeutic targets for the treatment of neurological disorders and stroke. ..
  56. Mechanisms of MAP2 degradation after in vitro ischemia.
    KATHLEEN SUSMAN; Fiscal Year: 2002
    ....
  57. ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELS
    Roger Nicoll; Fiscal Year: 2006
    ..abstract_text> ..
  58. TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  59. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
  60. Regulation of APP Processing by Par-4
    Qing Guo; Fiscal Year: 2007
    ..Inhibition of Par-4 activity by enhancing AATF expression and/or manipulating Par-4/APP interaction may provide novel therapeutic implications for Alzheimer's disease. ..
  61. Examination of PTL-1 in mechanosensory neurons of Caenorhabditis elegans
    KATHLEEN SUSMAN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  62. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  63. RNAi-mediated Silencing of Mutant Superoxide Dismutase
    MICHELE MAXWELL; Fiscal Year: 2006
    ..In addition, the therapeutic potential of RNAi will be assessed using viral delivery of shRNA to the spinal cords of mutant SOD1 transgenic mice. ..
  64. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
    ..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
  65. Effects of Stress on Pathology of Parkinson's Disease
    GERLINDE METZ; Fiscal Year: 2004
    ..These approaches will provide the opportunity to understand factors involved in the pathology of PD and to develop novel therapeutic strategies for neurodegenerative motor disorders. ..
  66. Role of Natriuretic Peptides in the Cochlea
    George Trachte; Fiscal Year: 2004
    ..abstract_text> ..