LMO3

Summary

Gene Symbol: LMO3
Description: LIM domain only 3
Alias: RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only protein 3, LIM domain only 3 (rhombotin-like 2), neuronal-specific transcription factor DAT1, rhombotin-3
Species: human

Top Publications

  1. pmc Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
    Hideo Watanabe
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:197-210. 2013
  2. ncbi LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma
    Mineyoshi Aoyama
    Division of Biochemistry, Chiba Cancer Center Research Institute, Japan
    Cancer Res 65:4587-97. 2005
  3. doi Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorph
    David K Miller
    LifeStream Solutions, Inc, Prescott, AZ, USA
    Postgrad Med 122:188-213. 2010
  4. pmc Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 35:161-77. 2009
  5. ncbi Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)
    Yu Feng
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 139:1-6. 2005
  6. ncbi High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD
    Emma M van der Meulen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Child Psychol Psychiatry 46:1074-80. 2005
  7. doi Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008
  8. pmc Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome
    T Sekizaki
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Bacteriol 183:500-11. 2001
  9. ncbi Dopamine transporter gene associated with diminished subjective response to amphetamine
    David C Lott
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:602-9. 2005
  10. doi Molecular genetics of attention
    Mark A Bellgrove
    School of Psychology, University of Queensland, 4072 Queensland, Australia
    Ann N Y Acad Sci 1129:200-12. 2008

Research Grants

Detail Information

Publications182 found, 100 shown here

  1. pmc Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
    Hideo Watanabe
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:197-210. 2013
    ..Integration of these expression and cistromic analyses identified LMO3, itself encoding a transcription regulator, as a candidate direct transcriptional target of NKX2-1...
  2. ncbi LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma
    Mineyoshi Aoyama
    Division of Biochemistry, Chiba Cancer Center Research Institute, Japan
    Cancer Res 65:4587-97. 2005
    LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination and differentiation during embryonic development...
  3. doi Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorph
    David K Miller
    LifeStream Solutions, Inc, Prescott, AZ, USA
    Postgrad Med 122:188-213. 2010
    ....
  4. pmc Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 35:161-77. 2009
    ..Pharmacogenetics uses genetic variation to predict individual differences in response to medications and holds much promise to improve treatment of addictive disorders...
  5. ncbi Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)
    Yu Feng
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 139:1-6. 2005
    ..Our results therefore refute the possibility of the reported DraI variation or alleles of the VNTR as the functional variants contributing to the disorder...
  6. ncbi High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD
    Emma M van der Meulen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Child Psychol Psychiatry 46:1074-80. 2005
    ..This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles...
  7. doi Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008
    ..015). This interaction might reflect the regulatory effect of COMT dominated prefrontal dopamine transmission on subcortical dopamine systems, which are the actual site of methylphenidate action...
  8. pmc Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome
    T Sekizaki
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Bacteriol 183:500-11. 2001
    ..These results suggest that the SsuDAT1I system could have been integrated into the S. suis chromosome by an illegitimate recombination mechanism...
  9. ncbi Dopamine transporter gene associated with diminished subjective response to amphetamine
    David C Lott
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:602-9. 2005
    ..The current findings have important implications for understanding the genetic determinants of variability in stimulant response and risk of abuse...
  10. doi Molecular genetics of attention
    Mark A Bellgrove
    School of Psychology, University of Queensland, 4072 Queensland, Australia
    Ann N Y Acad Sci 1129:200-12. 2008
    ....
  11. ncbi Pharmacogenetics of methylphenidate response in preschoolers with ADHD
    James McGough
    UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 45:1314-22. 2006
    ..The authors explored genetic moderators of symptom reduction and side effects in methylphenidate-treated preschool-age children diagnosed with attention-deficit/hyperactivity disorder (ADHD)...
  12. ncbi [Distribution of DRD4 and DAT1 alleles from dopaminergic system in a mixed Chilean population]
    Gonzalo Vieyra
    Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70061, Santiago 7, Chile
    Rev Med Chil 131:135-43. 2003
    ..7 (61%) than for DRD4.4 (29%). The ten repetition allele for DAT1 transporter has a high frequency among Europeans (72%) and Amerindians (100%). The allele DAT1*9 is the second most frequent allele...
  13. pmc Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients
    Zsofia Nemoda
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Behav Brain Funct 6:4. 2010
    ..However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD...
  14. ncbi Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  15. doi Case-control and within-family tests for an association between conduct disorder and DAT1
    R Jay Schulz-Heik
    Institute for Behavioral Genetics, Department of Psychology, University of Colorado, Boulder 80309, USA
    Psychiatr Genet 18:17-24. 2008
    ..Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children...
  16. doi [Combination of DRD4 and DAT1 genotypes is an important risk factor for attention deficit disorder with hyperactivity families living in Santiago, Chile]
    Hugo Henríquez B
    Centro de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Rev Med Chil 136:719-24. 2008
    ..Attention deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness...
  17. doi Abnormal adenosine and dopamine receptor expression in lymphocytes of Lesch-Nyhan patients
    M G Garcia
    Divisions of Clinical Biochemistry and Internal Medicine, La Paz University Hospital, Madrid, Spain
    Brain Behav Immun 23:1125-31. 2009
    ....
  18. doi The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation
    Pekka Santtila
    Center of Excellence in Behavior Genetics, Department of Psychology, Abo Akademi University, Turku, Finland
    J Sex Med 7:1538-46. 2010
    ..Previous research has suggested brain dopamine (DA) neurotransmission to be involved in the control of ejaculation. Furthermore, previous studies indicate a partly hereditary background to premature ejaculation...
  19. ncbi Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3)
    Dustin Y Yoon
    Department of Neurology, Johns Hopkins University School of Medicine, Harriet Lane Children s Health Building, Wolfe Street, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:605-10. 2007
    ..Since abnormalities of the dopamine transporter have been hypothesized in the pathophysiology of TS, it is possible that this could be a functional allele associated with clinical expression...
  20. ncbi Dopamine transporter, gender, and number of sexual partners among young adults
    Guang Guo
    Department of Sociology, University of North Carolina, Chapel Hill, NC 27599 3210, USA
    Eur J Hum Genet 15:279-87. 2007
    ..Discussion is provided why this finding is absent among females...
  21. ncbi The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence
    Yann Le Strat
    INSERM U675, IFR02, Faculté de Médecine Xavier Bichat Université, Henri Huchard, Paris, France
    Alcohol Clin Exp Res 32:27-35. 2008
    ..We investigated whether polymorphisms within the DAT1 gene are associated with WS taking into account some of the confounding factors such as the severity of alcohol dependence...
  22. pmc Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, NY 11794 8790, USA
    J Child Psychol Psychiatry 49:1331-8. 2008
    ....
  23. doi Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder
    Edmund J S Sonuga-Barke
    Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, Southampton, UK
    J Child Psychol Psychiatry 50:1052-63. 2009
    ....
  24. pmc Dopamine transporter gene variation modulates activation of striatum in youth with ADHD
    Anne Claude Bedard
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroimage 53:935-42. 2010
    ..These findings provide preliminary evidence that neural activity related to inhibitory control may differ as a function of DAT1 3'UTR genotype in youth with ADHD...
  25. ncbi [Association analysis between polymorphism of dopamine transporter variable number tandem repeat and breast cancer with abnormal Hilit]
    Xiao Mei Peng
    College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China
    Zhonghua Yi Xue Za Zhi 90:515-8. 2010
    ..To explore the association between polymorphism of dopamine 1 transporter variable number tandem repeat (DAT1 VNTR) and breast cancer with abnormal Hilit in Chinese Han population from Xinjiang...
  26. ncbi Potent agonists of growth hormone-releasing hormone. II
    M Zarandi
    Veterans Affairs Medical Center, New Orleans, LA 70146
    Pept Res 5:190-3. 1992
    ....
  27. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
    ..Multi-gene profiles in specific individuals may be of assistance in choosing the appropriate treatment...
  28. pmc Eating disorders with binge-eating behaviour are associated with the s allele of the 3'-UTR VNTR polymorphism of the dopamine transporter gene
    Manabu Shinohara
    Department of Neuropsychiatry, Graduate School of Medicine and Engineering, The University of Yamanashi, Nakakoma, Japan
    J Psychiatry Neurosci 29:134-7. 2004
    ....
  29. ncbi Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene
    Satoshi Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902
    J Biochem 137:205-16. 2005
    ..We also show that SNP of Hesr1, C386A, causes a lack of activity. These results suggest that Hesr1 and its polymorphism(s) might be involved in dopamine-related polygenic disorders and behavioral traits...
  30. ncbi Family-based association study of DAT1 and DRD4 polymorphism in Korean children with ADHD
    Young Shin Kim
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    Neurosci Lett 390:176-81. 2005
    ..Future studies are necessary to test the hypothesis generated in this study that the 5-repeat allele of DRD4 is protective for hyperactive-impulsivity symptom severity compared to the 4-repeat allele...
  31. ncbi Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer
    Daniele Campa
    International Agency for Research on Cancer, Lyon, France
    Lung Cancer 56:17-23. 2007
    ..The bioavailability of dopamine is regulated by dopamine receptors D2 (DRD2), D4 (DRD4) and dopamine transporter 1 (DAT1/SLC6A3) genes...
  32. ncbi Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3' UTR polymorphism of the dopamine transporter gene
    Zsanett Tarnok
    Vadaskert Child and Adolescent Psychiatric Clinic, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:900-5. 2007
    ..002). In summary, allele frequencies did not differ between cases and controls, but DAT1 genotype accounted for variations of tic severity within the TS group...
  33. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ....
  34. pmc The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors
    Guang Guo
    Department of Sociology, The University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9352. 2010
    ..These comparisons indicate that the protective effect of DAT1*9R/9R cannot be explained away by these background characteristics. Our work demonstrates how legal/social contexts can enhance or reduce a genetic effect on risky behaviors...
  35. doi Neither single-marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese
    Y W Yeh
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Genes Brain Behav 9:638-47. 2010
    ..This study suggests that the DAT1 gene may not contribute to the risk of HD and specific personality traits in HD among the Han Chinese population...
  36. pmc Association of attention-deficit disorder and the dopamine transporter gene
    E H Cook
    Department of Psychiatry, University of Chicago, IL, USA
    Am J Hum Genet 56:993-8. 1995
    ..Biochemical analysis of such mutations may lead to development of more effective therapeutic interventions...
  37. ncbi Sequence analysis of a small cryptic plasmid isolated from Streptococcus suis serotype 2
    D Takamatsu
    National Institute of Animal Health, 3 1 1 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Curr Microbiol 40:61-6. 2000
    ..Moreover, a 5-amino acid conserved sequence was found in C terminal of Rep and putative Rep proteins of several pMV158 family plasmids. These observations suggest that this plasmid replicates by use of the rolling circle mechanism...
  38. ncbi Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes
    M Salkovic-Petrisic
    Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Medical School, University of Zagreb, Zagreb, Croatia
    J Neural Transm (Vienna) 110:15-29. 2003
    ..Observed changes may suggest altered response to antidepressants in streptozotocin-icv treated rats, used as an animal model of sporadic Alzheimer's disease...
  39. pmc Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice
    E Tse
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 24:2063-73. 2004
    ..We have carried out gene targeting of the other members of the LIM-only family, viz., genes Lmo1, Lmo3 and Lmo4, to investigate their role in mouse development...
  40. ncbi DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  41. ncbi Dopamine transporter genotype and methylphenidate dose response in children with ADHD
    Mark A Stein
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:1374-82. 2005
    ..Further research is needed to determine the mechanisms related to poor response in patients with the 9/9-repeat genotype, and to determine if this group responds differentially to alternative treatments...
  42. pmc 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system
    Suparna Sengupta
    Department of Biophysical Chemistry, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India
    Br J Pharmacol 145:1076-83. 2005
    ..It would also be an interesting probe for the structure-function studies of tubulin-microtubule system...
  43. ncbi [Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]
    M Wohl
    CHU Robert Debré AP HP, Paris VII, 75019 Paris
    Encephale 31:437-47. 2005
    ..In addition, the development of pharmacogenetics could help to identify predictors of clinical response for a specific type of treatment, which would be clearly helpful in clinical practice...
  44. ncbi Identification of novel genes regulated in the developing human ventral mesencephalon
    Jesper Roland Jørgensen
    NsGene A S, Baltorpvej 154, DK 2750 Ballerup, Denmark
    Exp Neurol 198:427-37. 2006
    ..The data presented here may help to device cell replacement and regenerative therapies for Parkinson's disease (PD)...
  45. ncbi Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
    ..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
  46. pmc Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 31:210-21. 2010
    ..Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans...
  47. pmc Dopamine transporter genotype predicts implicit sequence learning
    Jessica R Simon
    Department of Psychology, Georgetown University, Washington, DC 20057, United States
    Behav Brain Res 216:452-7. 2011
    ....
  48. ncbi Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors
    K Buck
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, and Department of Veterans Affairs Research Service, Portland, Oregon 97201, USA
    Am J Med Genet 96:696-705. 2000
    ..These data suggest that the genes influencing locomotor activity, dopamine mimetic sensitivity, and tolerance do not overlap completely...
  49. ncbi Developmental expression of serum response factor in the rat central nervous system
    Janet L Stringer
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res Dev Brain Res 138:81-6. 2002
    ..that of myotonic dystrophy protein kinase, a potential upstream regulator, and of the LIM-only genes Lmo1, Lmo2 and Lmo3, whose products belong to a family of proteins known to be strong positive regulators of SRF's transcriptional ..
  50. ncbi Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study
    KAREN MULLER SMITH
    Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 119:77-85. 2003
    ..These results indicate that the DBH TaqI A allele, or another polymorphism in linkage disequilibrium with this allele, may confer increased susceptibility towards ADHD...
  51. ncbi Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
  52. doi A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions
    Giuseppe De Palma
    Department of Experimental and Applied Medicine, University of Brescia, Italy
    Mov Disord 25:912-9. 2010
    ..Owing to the retrospective design of the study, these results require confirmation...
  53. ncbi Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
    G Kirov
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Mol Psychiatry 4:558-65. 1999
    ..No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied...
  54. ncbi DRD3 and DAT1 genes in schizophrenia: an association study
    R Joober
    Douglas Hospital Research Centre, 6875 Boulevard LaSalle, H4H 1R3, Verdun, Canada
    J Psychiatr Res 34:285-91. 2000
    ..To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype...
  55. ncbi Construction and characterization of Streptococcus suis-Escherichia coli shuttle cloning vectors
    D Takamatsu
    Laboratory of Molecular Bacteriology, National Institute of Animal Health, 3 1 1 Kannondai, Tsukuba, Ibaraki, 305 0856, Japan
    Plasmid 45:101-13. 2001
    ..suis but not in E. coli. These results showed that pSET vectors are useful tools for cloning and analyzing S. suis genes in S. suis strains directly...
  56. ncbi [Associations between six functional genes and schizophrenia]
    Ming lian Zhang
    The Seventh People Hospital of Wuxi City, Wuxi, Jiangsu, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:69-71. 2003
    ....
  57. ncbi Genetic polymorphisms of serotonin and dopamine transporters in mental disorders
    Shu Ichi Ueno
    Department of Psychiatry, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 50:25-31. 2003
    ..So polymorphic variations of transporters would change the behavioral and neuropathological tendency. Here, the feature of those two transporters and their relations to psychiatric disorders are described...
  58. ncbi Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci
    Z Hawi
    Department of Genetics and Psychiatry, Trinity College, Dublin, Ireland
    Mol Psychiatry 8:299-308. 2003
    ..Further genetic analysis is unlikely to refine the location of susceptibility variants and functional assessment of variants within associated regions is required...
  59. ncbi Recent advances in the genetics of attention deficit hyperactivity disorder
    Lindsey Kent
    Developmental Psychiatry Section, University of Cambridge, Douglas House, Cambridge CB2 2AH, UK
    Curr Psychiatry Rep 6:143-8. 2004
    ..Current challenges in this field are to identify the actual functional variant(s) in these genes conferring susceptibility and other genetic and environmental risk factors for ADHD...
  60. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  61. ncbi Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
    ..A principal aim of genetic research is to provide new information that can resolve such clinical heterogeneity and that can be incorporated into diagnostic practice...
  62. doi A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 147:1568-75. 2008
    ....
  63. doi Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review
    Carmen S van der Zwaluw
    Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    Pharmacogenomics 10:853-66. 2009
    ..We discuss shortcomings, such as lack of power and disregarding moderating variables, as well as future challenges of gene association studies...
  64. doi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD...
  65. pmc Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder
    Reut Gruber
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada
    J Child Adolesc Psychopharmacol 19:233-9. 2009
    ..Preliminary evidence suggests that pharmacogenetic analysis using DAT1 variants shows promise for identifying individuals at increased or decreased risk for poor tolerability...
  66. pmc Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York, Putnam Hall, South Campus, Stony Brook, NY 11794 8790, USA
    J Autism Dev Disord 39:1542-51. 2009
    ..09) of BDNF genotype with DAT1 3' VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples...
  67. doi Dopaminergic haplotype as a predictor of spatial inattention in children with attention-deficit/hyperactivity disorder
    Mark A Bellgrove
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072
    Arch Gen Psychiatry 66:1135-42. 2009
    ..A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics...
  68. doi Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers
    M M Blanchard
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychol Med 41:611-8. 2011
    ..Our n-back task was designed to reflect WM alone, and made no demands on higher executive functioning...
  69. doi The molecular genetics of executive function: role of monoamine system genes
    Jessica J M Barnes
    Queensland Brain Institute and School of Psychology, University of Queensland, Brisbane, Australia
    Biol Psychiatry 69:e127-43. 2011
    ....
  70. doi Variation in genes involved in dopamine clearance influence the startle response in older adults
    Diana Armbruster
    Personality and Individual Differences, Institute of Psychology II, Dresden University of Technology, 01062, Dresden, Germany
    J Neural Transm (Vienna) 118:1281-92. 2011
    ..Although the functional significance of DAT1 VNTR is less defined, our results point to a potential influence of SLC6A3 on startle magnitude...
  71. pmc A dopamine receptor (DRD2) but not dopamine transporter (DAT1) gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure
    Katarzyna Kordas
    Department of Nutritional Sciences, Pennsylvania State University, State College, PA, USA
    J Pediatr 159:638-43. 2011
    ..To investigate the effects of prenatal and postnatal lead exposure and polymorphisms in dopamine metabolism genes on neurocognitive development of Mexican children at 24 months (n = 220) and 48 months (n = 186) of age...
  72. doi Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction
    Deeann Wallis
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 3474, USA
    Brain Res 1463:85-92. 2012
    ..Given the central role for monoamines in ADHD and addiction, it seems likely that the influence of LPHN3 genotype on these disorders is mediated through alterations in monoamine signaling...
  73. doi Association study between the dopamine-related candidate gene polymorphisms and ADHD among Saudi Arabia population via PCR technique
    Adel E El-Tarras
    Biotechnology and Genetic Engineering Unit, College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia
    Mol Biol Rep 39:11081-6. 2012
    ..Therefore further studies are needed to generalize obtained results at Saudi Arabia...
  74. pmc Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes
    Mallika Chatterjee
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030 6403, USA
    Development 139:4633-43. 2012
    ..LIM-domain transcription factors through three different mechanisms: Gbx2 and Lhx2 compete for binding to the Lmo3 promoter and exert opposing effects on its transcription; repressing Lmo3 by Gbx2 is essential for Lhx2 activity to ..
  75. doi Pharmacology and pharmacogenetics of pediatric ADHD with associated aggression: a review
    Bianca D Patel
    Division of Child and Adolescent Psychiatry, Cincinnati Children s Hospital, Cincinnati, OH, 45229 3026, USA
    Psychiatr Q 84:407-15. 2013
    ..Pharmacogenetics may be relevant to ADHD and associated aggression. Further research in pharmacogenetics will strive to identify patterns of genetic variations that can tailor individual treatments. ..
  76. doi Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females
    I Heitland
    Department of Experimental Psychology and Psychopharmacology, Utrecht University, Utrecht, The Netherlands
    Behav Brain Res 249:55-64. 2013
    ....
  77. doi [Transcranial magnetic stimulation (TMS), inhibition processes and attention deficit/hyperactivity disorder (ADHD) - an overview]
    Thomas Hoegl
    Kinder u Jugendabteilung für Psychische Gesundheit, Universitatsklinikum Erlangen
    Z Kinder Jugendpsychiatr Psychother 42:415-28; quiz 428-9. 2014
    ....
  78. doi A variable number of tandem repeats in the 3'-untranslated region of the dopamine transporter modulates striatal function during working memory updating across the adult age span
    Fabio Sambataro
    pRED, NORD DTA, Hoffmann La Roche, Basel, Switzerland
    Eur J Neurosci 42:1912-8. 2015
    ..Our data suggest that age and DAT1-3'-UTR-VNTR polymorphism independently modulate striatal function. ..
  79. pmc The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task
    Brenna K Brown
    Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Brain Imaging Behav . 2016
    ..This may indicate that 9R carriers exert more effort to overcome increased basal dopamine activation when inhibiting responses in emotional contexts...
  80. ncbi Cingulate Cortical Thickness and Dopamine Transporter (DAT1) Genotype in Children and Adolescents With ADHD
    Alberto Fernández-Jaén
    Hospital Universitario Quirón, Madrid, Spain CADE, Madrid, Spain
    J Atten Disord . 2016
    ..This study aimed to examine the influence of dopamine transporter gene (DAT1) 3'UTR genotype on cingulate cortical thickness in a large sample of children and adolescents with ADHD...
  81. pmc Bacillus subtilis gene coding for constitutive O6-methylguanine-DNA alkyltransferase
    F Morohoshi
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Nucleic Acids Res 17:6531-43. 1989
    ..The dat-1 mutation was shown to be caused by a structural rearrangement affecting the coding region, and the 0.8 kb transcripts of this gene were detected in dat+ cells but not in dat mutant cells...
  82. pmc Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity
    I D Waldman
    Department of Psychology, Emory University, Atlanta, Georgia, USA
    Am J Hum Genet 63:1767-76. 1998
    ..Our results replicate and extend previous findings of the association between the DAT1 gene and childhood ADHD. This represents one of the first replicated relations of a candidate gene and a psychiatric disorder in children...
  83. ncbi Dopamine transporter polymorphism associated with externalizing behavior problems in children
    Susan E Young
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 114:144-9. 2002
    ..001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70)...
  84. ncbi Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis
    Brion S Maher
    Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 12:207-15. 2002
    ..Overall, the meta-analyses support the involvement of the dopamine system genes in ADHD liability variation and suggest the need for studies examining interactions between these genes...
  85. ncbi [Association studies of G352A polymorphism of dopamine transporter gene in Han Chinese attention deficit hyperactivity disorder patients]
    Qiu jin Qian
    Peking University Institute of Mental Health, Beijing 100083, China
    Beijing Da Xue Xue Bao 36:626-9. 2004
    ..To investigate association of the new polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 with attention deficit hyperactivity disorder (ADHD) in Han Chinese children...
  86. pmc Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
    E E Forbes
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:60-70. 2009
    ..They further suggest that altered VS reactivity may represent a key neurobiological pathway through which these polymorphisms contribute to variability in behavioral impulsivity and related risk for substance use disorders...
  87. ncbi Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)
    J Sandra Kooij
    PsyQ, Psycho Medical Programs, The Hague, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:201-8. 2008
    ..The polymorphisms in DRD4 and the SLC6A2 were not associated with treatment response. This study supports a role of the SLC6A3 genotype in determining the response to MPH in the treatment of adults with ADHD...
  88. ncbi Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
    Edmund J S Sonuga-Barke
    School of Psychology, University of Southampton, Southampton, UK
    Am J Med Genet B Neuropsychiatr Genet 147:316-9. 2008
    ..We also observed no association of other SNPs with IQ in ADHD...
  89. ncbi Lack of association between the dopamine transporter gene 3' VNTR polymorphism and attention deficit hyperactivity disorder in Chinese Han children: case-control and family-based studies
    Yaping Wang
    Department of Psychiatry and Psychology, Second Affiliated Hospital, Xi an Jiaotong University, Xi Wu Lu, Xi an 710004, China
    Kobe J Med Sci 53:327-33. 2008
    ..And the TDT result showed that ADHD was not in linkage with the DAT1 gene. These findings do not support the hypothesis that DAT1 gene variants contribute to the pathogenesis of ADHD in Chinese Han population...
  90. doi Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  91. doi Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA
    Eur J Neurosci 32:1058-65. 2010
    ..DRD4 allelic variation may be a prognostic biomarker for challenging behaviors in children with autism spectrum disorder, but these exploratory findings remain tentative pending replication with larger independent samples...
  92. pmc Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats
    Tomasz Schneider
    Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 36:1114-25. 2011
    ..These data suggest a direct effect of prenatal nicotine exposure on important aspects of attention, inhibitory control, or learning later in life...
  93. doi The influence of dopamine-related genes on perceptual stability
    Katharina Schmack
    Department of Psychiatry, Charite Campus Mitte, Chariteplatz 1, Berlin, D 10117, Germany
    Eur J Neurosci 38:3378-83. 2013
    ....
  94. doi Association between gene variants and response to buprenorphine maintenance treatment
    Gilberto Gerra
    Drug Prevention and Health Branch, Division for Operations, United Nation Office on Drugs and Crime, Vienna, Austria
    Psychiatry Res 215:202-7. 2014
    ....
  95. pmc Simple sequence repeats in the national longitudinal study of adolescent health: an ethnically diverse resource for genetic analysis of health and behavior
    Brett C Haberstick
    Institute for Behavioral Genetics, University of Colorado Boulder, Campus Box 447, Boulder, CO, 80309 0447, USA
    Behav Genet 44:487-97. 2014
    ..The availability of these six SSRs in a large, ethnically diverse sample with extensive environmental measures assessed longitudinally offers a unique resource for researchers interested in health and behavior. ..
  96. doi Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection
    Daniel P Newman
    Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia
    J Neurosci 34:15743-50. 2014
    ....
  97. doi DAT1 and DRD4 genes involved in key dimensions of adult ADHD
    R Hasler
    Department of Psychiatry, University of Geneva, Geneva, Switzerland
    Neurol Sci 36:861-9. 2015
    ..Altogether, our results show the putative involvement of DAT1 and DRD4 genes in the aetiology of ADHD with a main role in modulation of key dimensions of the disorder...
  98. ncbi Gene-Environment Correlation Between the Dopamine Transporter Gene (DAT1) Polymorphism and Childhood Experiences of Abuse
    Wail Rehan
    Abo Akademi University, Turku, Finland
    J Interpers Violence . 2016
    ..In sum, the results suggested that some genetic components might predispose children to experience childhood abuse and neglect. Possible reasons for this association were discussed...
  99. doi Depressive symptoms in adolescence: The role of perceived parental support, psychological control, and proactive control in interaction with 5-HTTLPR
    E Van Assche
    GRASP research group, Department of Neuroscience, University of Leuven, Leuven, Belgium University Psychiatric Center KU Leuven, Leuven, Belgium Electronic address
    Eur Psychiatry 35:55-63. 2016
    ....
  100. ncbi Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder
    Claudia Szobot
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 132:53-8. 2005
    ..05). Our findings suggest that a higher recruitment in middle temporal gyrus, an area associated to working memory and selective attention, should exist to compensate a putative effect of the interaction between these dopaminergic genes...
  101. doi Dopaminergic and noradrenergic gene polymorphisms and response to methylphenidate in korean children with attention-deficit/hyperactivity disorder: is there an interaction?
    Soon Beom Hong
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Child Adolesc Psychopharmacol 22:343-52. 2012
    ....

Research Grants56

  1. Imaging the Neural Correlates of Genetic Risk for ADHD
    Clinton Kilts; Fiscal Year: 2005
    ..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
  2. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael C Stevens; Fiscal Year: 2012
    ..abstract_text> ..
  3. Variability in Brain Function Underlying Motivated Behavior in Adolescence
    Beatriz Luna; Fiscal Year: 2013
    ....
  4. Methylphenidate Use to Improve Outcomes in Geriatric Depression
    Helen Lavretsky; Fiscal Year: 2012
    ..Evaluating selected dopamine-related genes in late-life depression with respect to mood and cognitive symptoms, and treatment response may lead to the development of the targeted individualized treatments in geriatric depression. ..
  5. Smoking, Neurocircuitry, and Genes in Adult ADHD
    JEAN G GEHRICKE; Fiscal Year: 2013
    ..In the long term, such research will aid in the development of evidence-based smoking cessation and prevention programs. ..
  6. Imaging Genetic Predictors of Psychotherapy Outcomes in Unipolar Depression
    Moria J Smoski; Fiscal Year: 2013
    ....
  7. Function of LIM-domain Transcriptional Regulators in Inner Ear Development
    Lin Gan; Fiscal Year: 2012
    ..sensory organ and that the negative regulation of Isl1 function by the LIM-domain-only transcriptional regulators LMO3 and LMO4 restricts the competence to the presumptive OC (OC) region...
  8. AMY WOLVEN LASEK; Fiscal Year: 2016
    ..The genes include Lmo3 and Lmo4, which encode transcriptional regulators, Alk, which encodes a receptor tyrosine kinase, and Mdk, which ..
  9. Cumulative Genetic and Environmental Predictors of Youth Substance Use
    JENNIFER LYNN CARRANO; Fiscal Year: 2012
    ..Further, findings will add to what is still a rather sparse and contradictory literature on genetic effects on substance use and will help shed light on discrepant findings regarding gender differences in substance use etiology. ..
  10. Matthew L Meyerson; Fiscal Year: 2014
    ..3 amplicon that is required for lung adenocarcinoma cell survival. Specific Aim 3. Assess whether the LMO3 transcription factor gene is required for the survival of lung adenocarcinoma cells with and without NKX2-1 ..
  11. Jeanette E Eckel Passow; Fiscal Year: 2014
    ..that are differentially expressed in metastatic versus primary ccRCC: DCN, SLIT2, LUM, LAMA2, ADAMTS12, CEACAM6 and LMO3. Herein, we propose to expand on our pilot work by (1) validating these candidates in a large independent cohort of ..
  12. Etiology of Adolescent Depression: Gene and Social Environment Interactions
    ERIN CATHLEEN DUNN; Fiscal Year: 2010
    ..Results of this innovative, multi- level study will advance interdisciplinary knowledge on how to measure environment and when and where to intervene in the lives of youth to reduce their risk depression and promote their resilience. ..
  13. Parent and Peer Influences on Alcohol Use Problems: A Genetically Informed Study
    KAITLIN ELIZABETH BOUNTRESS; Fiscal Year: 2013
    ....
  14. Stephen V Faraone; Fiscal Year: 2014
    ..Although we have begun to work out many of these issues at prior conferences, we need to continue the series to build upon those achievements and to complete the collaborative plans laid out in prior conferences. ..
  15. MOLECULAR ANALYSIS OF THE DOPAMINE TRANSPORTER IN ADHD
    Edwin Cook; Fiscal Year: 1999
    ....
  16. Gene x Environment Interactions in Attention Deficit Hyperactivity Disorder
    Holly Barnard; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Integrating brain imaging and genetic analysis of ADHD
    CHANDAN VAIDYA; Fiscal Year: 2007
    ..Examination of such genotype-phenotype relationships will elucidate potential etiological factors and neuropathophysiology of ADHD that will be useful in diagnosis, early intervention, and treatment planning. ..
  18. GENETICS OF SMOKING AND NICOTINE DEPENDENCE IN FAMILIES
    Ovide Pomerleau; Fiscal Year: 2000
    ..Increased knowledge about the genetics of smoking will be needed in substantial improvements in the management of cigarette smoking and consequent reduction in cancer morbidity and mortality are to be achieved. ..
  19. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  20. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  21. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2005
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  22. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  23. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006
    ..Genomic haplotypes", meaning haplo-specific genotypes at more than one locus, will be defined and tested for possible interactive roles among the genes. ..
  24. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  25. UCI-CFC Projects on School Readiness
    James Swanson; Fiscal Year: 2002
    ....
  26. Epidemiological Investigations of ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  27. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  28. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2008
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  29. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  30. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  31. A BEHAVIORAL ECONOMIC APPROACH TO CHILDHOOD OBESITY
    Leonard Epstein; Fiscal Year: 2005
    ..This study will yield important information on new ways to treat pediatric obesity, minimizing dietary restriction and maximizing children learning healthier eating habits. ..
  32. Food reinforcement-genotype interactions and eating
    Leonard H Epstein; Fiscal Year: 2010
    ..The findings are relevant to a greater understanding of behavioral and genetic factors related to obesity, as well as providing ideas that may be relevant for treatment interventions for those high in food reinforcement. ..
  33. TEST OF A DISSONANCE EATING DISORDER PREVENTION PROGRAM
    Eric Stice; Fiscal Year: 2005
    ..Thus, the proposed study should be the definitive test of this new promising eating disorder prevention program and should significantly advance our knowledge regarding the prevention of this pervasive psychiatric problem. ..
  34. Genetics of EEG Patterns in ADHD
    Sandra K Loo; Fiscal Year: 2010
    ..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
  35. RESPONSE VARIABILITY IN STIMULANT TREATMENT OF ADHD
    James McGough; Fiscal Year: 2004
    ..In addition to funding the candidate's transition to independent research the proposed study would also contribute to our knowledge of the basis of individual response to medication in psychiatric disorders. ..
  36. EFFECTS OF CHANGING SEDENTARY BEHAVIOR IN OBESE CHILDREN
    Leonard Epstein; Fiscal Year: 2008
    ..Developing a better understanding of why obese youth increase physical activity or decrease energy intake when sedentary behaviors are reduced is important for the treatment of pediatric obesity. [unreadable] [unreadable] [unreadable]..
  37. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  38. ETIOLOGY OF BULIMIC PATHOLOGY--MULTIMETHOD INVESTIGATION
    Eric Stice; Fiscal Year: 2002
    ..Agras' and Taylor's labs, (2) learn state-of- the-art treatments for eating pathology and other adolescent psychopathology, (3) take courses in quantitative techniques, methodology, and ethics, and (4) receive training in grant writing. ..
  39. An Association Study of Neurogenin 1 and Schizophrenia
    Ayman Fanous; Fiscal Year: 2002
    ..If there are resources left over, we plan to genotype 400 normal controls and perform a case-control analysis using a chi-squared test to confirm any suggestive findings. ..
  40. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  41. Habituation to food in children
    Leonard Epstein; Fiscal Year: 2009
    ..These studies are designed to understand how individual differences in habituation may be an important factor that differentiates overweight and non-overweight youth. ..
  42. Eating Disorder Prevention Program Effectiveness Trial
    Eric Stice; Fiscal Year: 2009
    ..g. will use random assignment, an attention control condition, blinded diagnostic interviews, multiple-reporter data, and a long-term follow-up). ..
  43. Mechanisms of Change in Alcohol Treatment for Dually Diagnosed Youth
    Tammy Chung; Fiscal Year: 2008
    ..Results have important implications for improving the design and delivery of treatment provided to dually diagnosed adolescents. [unreadable] [unreadable] [unreadable]..
  44. Depression Prevention Program for High-Risk Adolescents
    Eric Stice; Fiscal Year: 2008
    ..Thus, the proposed project should provide a rigorous evaluation of this promising brief prevention program and should advance knowledge regarding the prevention of this pernicious psychiatric problem. [unreadable] [unreadable]..
  45. Modifying the home T.V. watching environment
    Leonard Epstein; Fiscal Year: 2005
    ..abstract_text> ..
  46. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. DIAGNOSTIC CRITERIA FOR ADOLESCENT ALCOHOL USE DISORDERS
    Tammy Chung; Fiscal Year: 2005
    ..This award will provide a solid foundation for the applicant to become an independent investigator specializing in adolescent alcohol problems. ..
  48. Genetic Polymorphism of a Schizophrenia Endophenotype
    Ikwunga Wonodi; Fiscal Year: 2007
    ..Deciphering the genetic mechanisms of prefrontal dopamine dysfunction in schizophrenia would advance our understanding of the pathophysiology of schizophrenia and may help identify novel treatments. [unreadable] [unreadable] [unreadable]..
  49. GENETICS OF ADHD
    Josephine Elia; Fiscal Year: 2007
    ..Dr. Douglas Levinson will provide mentoring in statistical methods and data analyses and Dr. Judith Rapoport will provide mentoring in defining novel phenotypic definitions for ADHD. ..
  50. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  51. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  52. Biochemical and Behavioral Correlates of IFN Response
    Jennifer Loftis; Fiscal Year: 2007
    ..Results will contribute to knowledge of IFN mechanisms that are important in HCV and in understanding depressive symptoms accompanying medical conditions where cytokines are elevated. ..
  53. Risk and Maintenance Factors for Bulimic Pathology
    Eric Stice; Fiscal Year: 2006
    ..abstract_text> ..
  54. Genetic Underpinnings of EEG Patterns in ADHD
    Sandra Loo; Fiscal Year: 2006
    ..Given the applicant's prior training, proposed mentorship, and outstanding resources, a K23 Award will enable her to become an independent and productive researcher in the genetics and developmental neuropsychology of ADHD. ..
  55. Executive Function: Links to Drug Use & Psychopathology
    Susan Young; Fiscal Year: 2006
    ..Our final aim is to determine the extent to which the covariation between ECF deficits and comorbid psychopathology is due to genetic and/or environmental factors. ..
  56. Endophenotypes for Molecular Genetic Studies of ADHD
    Ian Gizer; Fiscal Year: 2006
    ..abstract_text> ..