lipopolysaccharide binding protein

Summary

Gene Symbol: lipopolysaccharide binding protein
Description: lipopolysaccharide binding protein
Alias: BPIFD2, lipopolysaccharide-binding protein, BPI fold containing family D, member 2, LPS-binding protein
Species: human

Top Publications

  1. ncbi Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein
    Maja Pavcnik-Arnol
    Department of Pediatric Surgery and Intensive Care, University Medical Center Ljubljana, Zaloska 7, 1525 Ljubljana, Slovenia
    Intensive Care Med 30:1454-60. 2004
  2. ncbi Structure and function of lipopolysaccharide binding protein
    R R Schumann
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Science 249:1429-31. 1990
  3. ncbi Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide
    M A Dentener
    Department of Surgery, University of Limburg, Maastricht, The Netherlands
    J Immunol 151:4258-65. 1993
  4. ncbi Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response
    A C Vreugdenhil
    Department of General Surgery, Maastricht University, The Netherlands
    J Immunol 163:2792-8. 1999
  5. ncbi Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins
    M A Dentener
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 23:146-53. 2000
  6. ncbi Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis
    J A Hubacek
    Institute for Clinical Chemistry and Laboratory Medicine, The University of Regensburg, Germany
    Crit Care Med 29:557-61. 2001
  7. pmc Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells
    T Gutsmann
    Department of Immunochemistry and Biochemical Microbiology, Center for Medicine and Biosciences, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 69:6942-50. 2001
  8. ncbi High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
    J Zweigner
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Blood 98:3800-8. 2001
  9. ncbi Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
    Anita C E Vreugdenhil
    Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, Maastricht University, Maastricht, The Netherlands
    J Immunol 170:1399-405. 2003
  10. ncbi Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:15587-94. 2003

Research Grants

  1. Helene M Langevin; Fiscal Year: 2015
  2. LINDA R VANDILLEN; Fiscal Year: 2016
  3. Recurrent Low Back Pain: Linking Mechanisms to Outcomes
    Sheri P Silfies; Fiscal Year: 2010
  4. Gram-Negative Pneumonia and Lipopolysaccharide Binding Protein
    MARK RICHARD HEMMILA; Fiscal Year: 2010
  5. XV INTERNATIONAL CONGRESS OF NUTRITION
    RICHARD ALLISON; Fiscal Year: 1993
  6. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
  7. Chandrashekhar R Gandhi; Fiscal Year: 2016
  8. MENG CARLA WANG; Fiscal Year: 2016
  9. Jerrold Weiss; Fiscal Year: 2014
  10. Timothy R Billiar; Fiscal Year: 2016

Detail Information

Publications303 found, 100 shown here

  1. ncbi Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein
    Maja Pavcnik-Arnol
    Department of Pediatric Surgery and Intensive Care, University Medical Center Ljubljana, Zaloska 7, 1525 Ljubljana, Slovenia
    Intensive Care Med 30:1454-60. 2004
    ..To evaluate markers of infection in critically ill neonates and children, comparing lipopolysaccharide-binding protein (LBP) with procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP)...
  2. ncbi Structure and function of lipopolysaccharide binding protein
    R R Schumann
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Science 249:1429-31. 1990
    The primary structure of lipopolysaccharide binding protein (LBP), a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPSs), was deduced by sequencing cloned complementary DNA...
  3. ncbi Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide
    M A Dentener
    Department of Surgery, University of Limburg, Maastricht, The Netherlands
    J Immunol 151:4258-65. 1993
    Serum proteins play an important role in LPS-induced cell activation. The LPS binding protein (LBP) enhances cellular responses to LPS, whereas the polymorphonuclear leukocyte product bactericidal/permeability-increasing protein (BPI) ..
  4. ncbi Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response
    A C Vreugdenhil
    Department of General Surgery, Maastricht University, The Netherlands
    J Immunol 163:2792-8. 1999
    The acute phase proteins LPS binding protein (LBP) and serum amyloid A (SAA) are produced by the liver and are present in the circulation. Both proteins have been shown to participate in the immune response to endotoxins...
  5. ncbi Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins
    M A Dentener
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 23:146-53. 2000
    ..The local production of this endotoxin binding protein by lung epithelial cells might contribute to a highly specific response at the site of exposure to bacteria and bacterial endotoxins...
  6. ncbi Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis
    J A Hubacek
    Institute for Clinical Chemistry and Laboratory Medicine, The University of Regensburg, Germany
    Crit Care Med 29:557-61. 2001
    ..BPI) (Lys216 --> Glu; PstI polymorphism in intron 5; silent mutation G545 --> C) and the lipopolysaccharide binding protein (LBP) (Cys98 --> Gly; Pro436 --> Leu) are associated with the incidence and lethality of sepsis...
  7. pmc Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells
    T Gutsmann
    Department of Immunochemistry and Biochemical Microbiology, Center for Medicine and Biosciences, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 69:6942-50. 2001
    ....
  8. ncbi High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
    J Zweigner
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Blood 98:3800-8. 2001
    ..In summary, the inhibition of LPS effects by high concentrations of LBP in acute-phase serum, as described here, may represent a novel defense mechanism of the host in severe sepsis and during bacterial infections...
  9. ncbi Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
    Anita C E Vreugdenhil
    Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, Maastricht University, Maastricht, The Netherlands
    J Immunol 170:1399-405. 2003
    ..Besides a role in the detoxification of bacterial toxin present in the circulation, we believe that LBP-chylomicron complexes may be part of a local defense mechanism of the intestine against translocated bacterial toxin...
  10. ncbi Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:15587-94. 2003
    ..However, the involvement of TLR-4 and MD-2 in this process was ruled out...
  11. pmc Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation
    Jason W Chien
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 111:2462-9. 2008
    b>Lipopolysaccharide binding protein (LBP) function is dependent on circulating LBP levels. Disturbance of LBP transcription regulation may influence the risk for clinical events...
  12. doi Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers
    V Regueiro
    Program Infection and Immunity, Fundació Caubet CIMERA Illes Balears, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Spain
    Eur Respir J 33:273-81. 2009
    ..Thus, in the inflamed airways of smokers both proteins could contribute to inhibit bacteria-dependent cellular activation without compromising the internalisation of pathogens by airway cells...
  13. pmc Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 4:e6818. 2009
    ..We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examined whether serial serum levels of LBP ..
  14. pmc A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 33:1925-32. 2010
    ..We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese...
  15. pmc Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity
    Arturo Gonzalez-Quintela
    Department of Internal Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    PLoS ONE 8:e54600. 2013
    ....
  16. ncbi Soluble (s) CD14 and plasmatic lipopolysaccharides (LPS) in patients with chronic hepatitis C before and after treatment with interferon (IFN)-alpha
    E Jirillo
    I.R.C.C.S. S. de Bellis, Laboratory of Immunopathology, Castellana Grotte (Bari
    Immunopharmacol Immunotoxicol 20:1-14. 1998
    CDI4 is a monocyte/polymorphonuclear cell receptor for lipopolysaccharide (LPS)-LPS Binding Protein (LBP), which mediates most of the toxic effects exerted by such a bacterial component in the host...
  17. ncbi A comparison of equine and bovine sera as sources of lipopolysaccharide-binding protein activity in equine monocytes incubated with lipopolysaccharide
    Monica D Figueiredo
    Department of Large Animal Medicine, The University of Georgia, Athens, GA 30602 7385, USA
    Vet Immunol Immunopathol 121:275-80. 2008
    ..Although the heat inactivation process did not affect the LBP activity in CES, it ablated LBP activity in AES. Consequently, investigators are advised to utilize either CES or AES in future studies, but not heat-inactivated AES...
  18. ncbi Capacity of the clinical picture to characterize low back pain relieved by facet joint anesthesia. Proposed criteria to identify patients with painful facet joints
    M Revel
    , , Paris, France
    Spine (Phila Pa 1976) 23:1972-6; discussion 1977. 1998
    ..These characteristics should not, however, be considered as definite diagnostic criteria of lower back pain originating from facet joints...
  19. ncbi Predicting long-term disability in low back injured workers presenting to a spine consultant
    T R Lehmann
    Louisville Orthopedic Clinic and Sports Rehabilitation Center, Kentucky
    Spine (Phila Pa 1976) 18:1103-12. 1993
    ..DCLBP was found to be correlated only with marital status, as married patients returned to work more quickly than single patients (P < 0.01).(ABSTRACT TRUNCATED AT 400 WORDS)..
  20. pmc Acute phase response in two consecutive experimentally induced E. coli intramammary infections in dairy cows
    Leena Suojala
    Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, FI 04920 Saarentaus, Finland
    Acta Vet Scand 50:18. 2008
    Acute phase proteins haptoglobin (Hp), serum amyloid A (SAA) and lipopolysaccharide binding protein (LBP) have suggested to be suitable inflammatory markers for bovine mastitis...
  21. ncbi Health care utilization for low back pain in Belgium. Influence of sociocultural factors and health beliefs
    M Szpalski
    , Longchamp, Brussels, Belgium
    Spine (Phila Pa 1976) 20:431-42. 1995
    ..The association of history of spinal surgery with reports of daily LBP suggests that spinal surgery has failed, at least partly, to relieve LBP...
  22. ncbi Classification of nonspecific low back pain. I. Psychological involvement in low back pain. A clinical, descriptive approach
    J Coste
    Service de Rhumatologie, , Boulogne, France
    Spine (Phila Pa 1976) 17:1028-37. 1992
    ....
  23. doi Factors associated with concentrations of select cytokine and acute phase proteins in dairy cows with naturally occurring clinical mastitis
    J R Wenz
    Field Disease Investigation Unit, Department of Clinical Sciences, Washington State University, Pullman 99164, USA
    J Dairy Sci 93:2458-70. 2010
    ..Furthermore, the results of this study provide useful data for planning future studies examining the role of the innate immune response in CM...
  24. ncbi Low-back pain in pregnancy. Abdominal muscles, sit-up performance, and back pain
    A Fast
    Department of Physical Medicine and Rahabilitation, St Vincent s Hospital and Medical Center of New York, New York
    Spine (Phila Pa 1976) 15:28-30. 1990
    ..6% of pregnant women could not perform a single sit-up. There was no statistically significant correlation between the sit-up performance and backache. It may be concluded that during pregnancy the abdominal muscles become insufficient...
  25. ncbi Determinants of sciatica and low-back pain
    M Heliovaara
    Research Institute for Social Security, Social Insurance Institution, Helsinki, Finland
    Spine (Phila Pa 1976) 16:608-14. 1991
    ..4; 95% CI, 0.3-0.8). Many factors, independent of each other, determine the occurrence of chronic low-back syndromes. The determinants of sciatica and LBP are different to some extent...
  26. ncbi Psychomotor speed and postural control in chronic low back pain patients A controlled follow-up study
    S Luoto
    ORTON Rehabilitation Centre, Invalid Foundation, Helsinki, Finland
    Spine (Phila Pa 1976) 21:2621-7. 1996
    ..Psychomotor speed improved during an active, functional, restoration back rehabilitation program...
  27. ncbi An epidemiologic study of occupational low back pain in truck drivers
    M Miyamoto
    Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 67:186-90. 2000
    ..From the viewpoint of prophylaxis, an improvement in working conditions reduces the incidence of drivers' LBP to some extent...
  28. ncbi Anthropometric measurements and the incidence of low back pain in a cohort of pubertal children
    M Nissinen
    Laakso Hospital, Helsinki, Finland
    Spine (Phila Pa 1976) 19:1367-70. 1994
    ..These associations were not significant in girls. CONCLUSIONS. Sitting height and trunk asymmetry may contribute to LBP in pubertal children. The role of anthropometric characteristics seems, however, modest...
  29. ncbi C-terminal fragment of human laminin-binding protein contains a receptor domain for venezuelan equine encephalitis and tick-borne encephalitis viruses
    A A Malygin
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia
    Biochemistry (Mosc) 74:1328-36. 2009
    ....
  30. ncbi Evidence of lumbar multifidus muscle wasting ipsilateral to symptoms in patients with acute/subacute low back pain
    J A Hides
    Department of Physiotherapy, Mater Hospital, Brisbane, Australia
    Spine (Phila Pa 1976) 19:165-72. 1994
    ..The fact that reduced CSA, i.e., wasting, was unilateral and isolated to one level suggests that the mechanism of wasting was not generalized disuse atrophy or spinal reflex inhibition.(ABSTRACT TRUNCATED AT 250 WORDS)..
  31. ncbi Validity of patient reporting and predictive value of industrial physical work demands
    I Lindström
    Department of Orthopaedics, University of Goteborg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 19:888-93. 1994
    ..This prospective study analyzed industrial physical work demands. The patients (n = 103), sick-listed 8 weeks because of low back pain, were industrial blue-collar workers in the car manufacturing industry...
  32. ncbi Occupational disability due to low back pain: a new interdisciplinary classification based on a phase model of disability
    N Krause
    Department of Epidemiology, School of Public Health, University of California at Berkeley
    Spine (Phila Pa 1976) 19:1011-20. 1994
    ..The authors propose an eight-phase classification system primarily based on the duration of work disability and that takes into account other biomedical, developmental, and social characteristics of work-disability resulting from LBP...
  33. pmc A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain
    Marienke van Middelkoop
    Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Eur Spine J 20:19-39. 2011
    ....
  34. ncbi Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 61:598-605; discussion 605-6. 2006
    b>Lipopolysaccharide binding protein (LBP) plays an essential role in the pulmonary immune response to gram-negative bacterial infection...
  35. ncbi Prevalence and risk factors of low back pain among nurses in Africa: Nigerian and Ethiopian specialized hospitals survey study
    Lamina Sikiru
    Department of Physiology Physiotherapy, Faculty of Medical Sciences, Jimma University, Ethiopia
    East Afr J Public Health 6:22-5. 2009
    ..The objective of this study was to determine the prevalence and risk factors of LBP among nurses in African...
  36. pmc High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study
    Jana Pavare
    Riga Stradins University, Chair of Pediatrics, Riga, Latvia
    BMC Infect Dis 10:28. 2010
    ..The second aim was to examine HMGB1, LBP, IL6 and CRP as markers for of bacteraemia...
  37. ncbi Clinical critical qualitative evaluation of the selected randomized controlled trials in current acupuncture researches for low back pain
    Edwin Yong Miao
    M Modern Traditional Chinese Medical Clinic, Ringwood, Victoria, Australia
    Zhong Xi Yi Jie He Xue Bao 8:1133-46. 2010
    ..Many randomized controlled trials (RCTs) and reviews concluded that acupuncture is not an effective treatment for low back pain (LBP) and there is no difference between real acupuncture and sham acupuncture in the treatment of LBP...
  38. pmc Expression of lipopolysaccharide binding protein and its receptor CD14 in experimental alcoholic liver disease
    G Q Zuo
    Department of Digestive Disease, Second College of Clinical Medicine and the Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    World J Gastroenterol 7:836-40. 2001
    ..To evaluate the relationship between the expression of lipopolysaccharides (LPS) binding protein (LBP) and CD14 mRNA and the severity of liver injury in alcohol-fed rats...
  39. ncbi Classification of nonspecific low back pain. II. Clinical diversity of organic forms
    J Coste
    Service de Rhumatologie, , Boulogne, France
    Spine (Phila Pa 1976) 17:1038-42. 1992
    ..More comprehensive descriptions and evaluations of clinical symptoms and syndromes appear necessary in order to elaborate a clinical classification of LBP...
  40. ncbi An epidemiological study on occupational low back pain among people who work in construction
    K Kaneda
    Department of Orthopedic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
    J Nippon Med Sch 68:310-7. 2001
    ..These findings have led us to the conclusion that not only providing good physical working environments, but also giving instructive and psychological care are important in preventing the onset of LBP in construction workers...
  41. ncbi Sociocultural factors and back pain. A population-based study in Belgian adults
    M L Skovron
    Hospital for Joint Diseases, New York University School of Medicine, New York
    Spine (Phila Pa 1976) 19:129-37. 1994
    ..Prospective studies are needed to confirm these results and elucidate causal relationships...
  42. pmc Symptomatology of recurrent low back pain in nursing and administrative professions
    Peter Schenk
    Center for Organisational and Occupational Health Sciences ZOA, ETH Zurich, Leonhardstrasse 25a, 8092, Zurich, Switzerland
    Eur Spine J 16:1789-98. 2007
    ....
  43. ncbi The relationship of low-back pain to pregnancy and gynecologic factors
    H O Svensson
    Department of Orthopaedic Surgery I, Sahlgren Hospital, University of Goteborg, Sweden
    Spine (Phila Pa 1976) 15:371-5. 1990
    ..In 50- to 64-year-old women, two variables were directly associated to LBP viz., a higher number of live births and a higher frequency of menopausal symptoms...
  44. doi Can cost utility evaluations inform decision making about interventions for low back pain?
    Simon Dagenais
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5 Canada
    Spine J 9:944-57. 2009
    ..Numerous interventions are routinely used, although few are supported by strong evidence. Cost utility analyses (CUAs) may be helpful to inform decision makers...
  45. ncbi A study of work stress, patient handling activities and the risk of low back pain among nurses in Hong Kong
    Y Yip
    Department of Nursing and Health Sciences, Faculty of Health and Social Studies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
    J Adv Nurs 36:794-804. 2001
    ..Low back pain (LBP) remains a common and costly problem among the nursing profession. Several studies have indicated that LBP is attributed to mentally straining or demanding work, fatigue or exhaustion or general work satisfaction...
  46. ncbi Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis
    Gert Bronfort
    Department of Research, Wolfe Harris Center for Clinical Studies, Northwestern Health Sciences University, 2501 W, 84th Street Bloomington, MN 55431, USA
    Spine J 4:335-56. 2004
    ....
  47. doi Physical workload, low back pain and neck-shoulder pain: a Swedish twin study
    T Nyman
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Occup Environ Med 66:395-401. 2009
    ....
  48. pmc The predictive effect of fear-avoidance beliefs on low back pain among newly qualified health care workers with and without previous low back pain: a prospective cohort study
    Jette Nygaard Jensen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Musculoskelet Disord 10:117. 2009
    ....
  49. ncbi The biomechanics of the lumbosacral region in acute and chronic low back pain patients
    Güldal Funda Nakipoğlu
    Ankara Physical Medicine and Rehabilitation Education and Research Hospitals, Ankara, Turkey
    Pain Physician 11:505-11. 2008
    ..We chose to investigate the lumbar lordosis angle, segmental lumbar lordosis angle, SIA, LSA and SHA in acute and chronic low back pain (LBP) patients as well as the correlation between spinal stability and these angles...
  50. doi Synthesis of recommendations for the assessment and management of low back pain from recent clinical practice guidelines
    Simon Dagenais
    Palladian Health, 2732 Transit Rd, West Seneca, NY 14224, USA
    Spine J 10:514-29. 2010
    ..The quality and consistency of recommendations from these CPGs are currently unknown...
  51. ncbi Variations in balance and body sway in middle-aged adults. Subjects with healthy backs compared with subjects with low-back dysfunction
    N Nies
    Graduate Program in Physical Therapy, University of California, San Francisco
    Spine (Phila Pa 1976) 16:325-30. 1991
    ..Effective physical therapy assessment and treatment of LBP patients may require attention to postural alignment, strength, flexibility, joint stability, balance reactions, and postural strategies...
  52. ncbi Socio-psychological stressors as risk factors for low back pain in Chinese middle-aged women
    Y B Yip
    Department of Nursing and Health Sciences, Faculty of Health and Social Studies, Hong Kong Polytechnic University, Hong Kong, China
    J Adv Nurs 36:409-16. 2001
    ..This study aims to explore the relationship between socio-psychological stress and low back pain (LBP) prevalence among Chinese middle-aged women...
  53. pmc Effects of chronic low back pain on trunk coordination and back muscle activity during walking: changes in motor control
    Claudine J C Lamoth
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    Eur Spine J 15:23-40. 2006
    ..Clinically, the results imply that conservative therapy should consider gait training as well as exercises aimed at improving both intersegmental and muscle coordination...
  54. pmc Investigation of elevated fear-avoidance beliefs for patients with low back pain: a secondary analysis involving patients enrolled in physical therapy clinical trials
    Steven Z George
    Department of Physical Therapy, Brooks Center for Rehabilitation Studies, University of Florida, Gainesville, FL 32611 0154, USA
    J Orthop Sports Phys Ther 38:50-8. 2008
    ..Secondary analysis...
  55. doi Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 36:2014-22. 2008
    We investigated the time course of lipopolysaccharide binding protein (LBP) plasma concentrations in patients in the surgical intensive care unit (ICU), their value in discriminating sepsis from systemic inflammatory response syndrome, ..
  56. ncbi Identifying patients at risk of becoming disabled because of low-back pain. The Vermont Rehabilitation Engineering Center predictive model
    W L Cats Baril
    School of Business Administration, McClure Musculoskeletal Research Center, University of Vermont, Burlington
    Spine (Phila Pa 1976) 16:605-7. 1991
    ....
  57. ncbi Effects of lifestyle and work-related physical activity on the degree of lumbar lordosis and chronic low back pain in a Middle East population
    M R Nourbakhsh
    University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    J Spinal Disord 14:283-92. 2001
    ..This finding indicates that the effect of these factors on LBP involves mechanisms other than changing the degree of lumbar lordosis...
  58. ncbi Work retention and nonspecific low back pain
    Marco A Campello
    Occupational and Industrial Orthopaedic Center, NYU Hospital for Joint Diseases, New York, NY 10014, USA
    Spine (Phila Pa 1976) 31:1850-7. 2006
    ..A cohort study of patients with nonspecific low back pain (LBP) participated in a 4-week multidisciplinary rehabilitation program...
  59. doi The role of physical fitness as risk indicator of increased low back pain intensity among people working with physically and mentally disabled persons: a 30-month prospective study
    Jesper Strøyer
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Spine (Phila Pa 1976) 33:546-54. 2008
    ..A prospective cohort study...
  60. pmc Effects of attention on the control of locomotion in individuals with chronic low back pain
    Claudine J C Lamoth
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Neuroeng Rehabil 5:13. 2008
    ..Conversely, because chronic pain has a strong attentional component, diverting attention away from the pain might facilitate a more efficient walking pattern...
  61. doi Radiographic predictors of residual low back pain after laminectomy for lumbar spinal canal stenosis: minimum 5-year follow-up
    Yingpeng Xia
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Spinal Disord Tech 21:153-8. 2008
    ..Retrospective study of patients who underwent laminectomy for unification...
  62. pmc Psychosocial education improves low back pain beliefs: results from a cluster randomized clinical trial (NCT00373009) in a primary prevention setting
    Steven Z George
    Department of Physical Therapy, Brooks Center for Rehabilitation Studies, Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL 32610 0154, USA
    Eur Spine J 18:1050-8. 2009
    ..This is the first randomized trial to show positive influence on LBP beliefs in a primary prevention setting, and these findings have potentially important public health implications for prevention of LBP...
  63. ncbi The relationship of low-back pain, work history, work environment, and stress. A retrospective cross-sectional study of 38- to 64-year-old women
    H O Svensson
    Department of Orthopaedic Surgery I, Sahlgren Hospital, , Sweden
    Spine (Phila Pa 1976) 14:517-22. 1989
    ..In a covariate analysis, however, only the three psychological variables remained directly associated to LBP viz. dissatisfaction with the work environment, a higher degree of worry, and fatigue at the end of the work day...
  64. ncbi 1987 Volvo award in clinical sciences. The perception of back pain and the role of psychophysical tests of lifting capacity
    J D Troup
    Department of Orthopaedic and Accident Surgery, University of Liverpool, United Kingdom
    Spine (Phila Pa 1976) 12:645-57. 1987
    ..But when the previous history of LBP was known, then the test results significantly enhanced the prediction...
  65. ncbi Low back pain. Epidemiologic aspects and work-related factors in the steel industry
    D Masset
    Occupational Hygiene and Work Physiology Unit, Catholic University of Louvain, Brussels, Belgium
    Spine (Phila Pa 1976) 19:143-6. 1994
    ..15). The other characteristics of the working conditions such as physical workload, postures and movements of the trunk, or exposure to whole body vibrations were not associated with an increased prevalence of LBP...
  66. pmc A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study
    Shahin Gaïni
    Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK 5000 Odense C, Denmark
    Crit Care 11:R76. 2007
    ..The study plan included analysis of the levels of the inflammatory markers in relation to the severity of infection, to the prognosis and to the ability to identify patients with bacteraemia...
  67. ncbi Stiffness and neuromuscular reflex response of the human spine to posteroanterior manipulative thrusts in patients with low back pain
    C J Colloca
    Postdoctoral and Related Professional Education Department, Logan College of Chiropractic, St Louis, MO, USA
    J Manipulative Physiol Ther 24:489-500. 2001
    ....
  68. pmc Association between sitting and occupational LBP
    Angela Maria Lis
    Occupational and Industrial Orthopaedic Center, New York, NY, USA
    Eur Spine J 16:283-98. 2007
    ....
  69. ncbi A retrospective study of low-back pain in 38- to 64-year-old women. Frequency of occurrence and impact on medical services
    H O Svensson
    Department of Orthopedic Surgery, Sahlgren Hospital, University of Goteborg, Sweden
    Spine (Phila Pa 1976) 13:548-52. 1988
    ..01). Increased LBP when performing certain activities of daily living was common, and significantly more pronounced in the older age group...
  70. pmc Prevalence of and risk factors for different measures of low back pain among female nursing aides in Taiwanese nursing homes
    Chao Kang Feng
    Institute of Public Health, National Yang Ming University No 155, Taipei, Taiwan
    BMC Musculoskelet Disord 8:52. 2007
    ..This study aimed to assess the prevalence of and risk factors for different measures of LBP among NAs in Taiwan...
  71. ncbi Modic changes, possible causes and relation to low back pain
    H B Albert
    All The Back Research Center, Part of Clinical Locomotion Science, University of Southern Denmark, Lindevej 5, 5750 Ringe, Denmark
    Med Hypotheses 70:361-8. 2008
    ..The MC could be the visible signs of the inflammation and oedema surrounding this infection, because the anaerobic bacteria cannot thrive in the highly aerobic environment of the MC type 1...
  72. doi Atherosclerosis and disc degeneration/low-back pain--a systematic review
    L I Kauppila
    Terveystalo Healthcare, Helsinki, Finland
    Eur J Vasc Endovasc Surg 37:661-70. 2009
    ..The diminished blood flow could result in various back problems. The aim of this systematic literature review was to assess associations between atherosclerosis and disc degeneration (DD) or low-back pain (LBP)...
  73. ncbi Low-back pain and occupation. A cross-sectional questionnaire study of men in machine operating, dynamic physical work, and sedentary work
    H Riihimaki
    LEL Employment Pension Fund, Helsinki, Finland
    Spine (Phila Pa 1976) 14:204-9. 1989
    ..Allowing for other risk indicators, the relative risk was 1.3 contrasting machine operators with both office workers and carpenters, but carpenters had no excess risk as compared with office workers...
  74. ncbi Traction for low back pain with or without sciatica: an updated systematic review within the framework of the Cochrane collaboration
    Judy Clarke
    Institute for Work and Health, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 31:1591-9. 2006
    ..Systematic review...
  75. ncbi A review of studies on seated whole body vibration and low back pain
    M H Pope
    Department of Environmental and Occupational Medicine, University of Aberdeen, Scotland, UK
    Proc Inst Mech Eng H 213:435-46. 1999
    ..Physiologic changes also occur with WBV. The risk of LBP can be reduced by vibration damping, good ergonomic design, reducing exposure, and reducing other risks such as lifting...
  76. ncbi Fear-avoidance beliefs and distress in relation to disability in acute and chronic low back pain
    Margreth Grotle
    Section for Health Science, University of Oslo, P O Box 1153 Blindern, N 0316 Oslo, Norway
    Pain 112:343-52. 2004
    ..The results replicate previous reports on the association between pain experience, fear-avoidance beliefs, distress, and disability in chronic LBP, and extend the findings to patients at an early stage of acute LBP...
  77. ncbi Clinical course and impact of fear-avoidance beliefs in low back pain: prospective cohort study of acute and chronic low back pain: II
    Margreth Grotle
    National Resource Center for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
    Spine (Phila Pa 1976) 31:1038-46. 2006
    ..Prospective inception cohort study...
  78. ncbi [Israeli guidelines for prevention of low back pain]
    A Lahad
    Department of Family, Hebrew University, Jerusalem, Israel
    Harefuah 146:253-7, 320. 2007
    ..Despite the intuitive appeal of the idea, there is no evidence, at this time, that attempts to prevent LBP in schoolchildren will have any impact on LBP in adults (Level D)...
  79. pmc Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 34:199-205. 2009
    ..Cross-sectional study...
  80. doi Factors associated with variability in length of sick leave because of acute low back pain in Chile
    Claudio Diaz-Ledezma
    Department of Orthopaedic Surgery, Mutual de Seguridad CChC, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile
    Spine J 9:1010-5. 2009
    ..Most research on risk factors for prolonged sick leave because of LBP has been done in Anglo-Saxon or Northern European populations with occupational LBP. Few studies have been conducted in less affluent Latin countries...
  81. ncbi Compliance for low-back pain patients in the emergency department. A randomized trial
    S L Jones
    School of Nursing, Kent State University, Ohio
    Spine (Phila Pa 1976) 13:553-6. 1988
    ..Other factors predicting compliance included persistence of pain symptoms, previous treatment of LBP by a health care provider, and an unmet need for child care...
  82. ncbi Successful treatment of low back pain and neck pain after a motor vehicle accident despite litigation
    J Schofferman
    SpineCare Medical Group, San Francisco Spine Institute, Daly City, California
    Spine (Phila Pa 1976) 19:1007-10. 1994
    ..CONCLUSION. Patients with low back pain or neck pain resulting from a motor vehicle accident showed a statistically significant improvement with treatment despite ongoing litigation...
  83. ncbi Distinguishable groups of musculoskeletal low back pain patients and asymptomatic control subjects based on physical measures of the NIOSH Low Back Atlas
    M T Moffroid
    Department of Physical Therapy, University of Vermont, Burlington
    Spine (Phila Pa 1976) 19:1350-8. 1994
    ..Distinguishable groups can be determined; decreased trunk mobility characterized all groups of patients and imbalances in muscle length, strength, and symmetry described specific groups of subjects with and without low back pain...
  84. ncbi Tall stature, overweight and the prevalence of low back pain in Chinese middle-aged women
    Y B Yip
    Department of Nursing and Health Sciences, Faculty of Health and Social Studies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Republic of China
    Int J Obes Relat Metab Disord 25:887-92. 2001
    ..First, to estimate the rate and characteristic of low back pain (LBP) among Hong Kong middle-aged women. Second, to explore the relationship between being overweight, having tall stature and LBP prevalence...
  85. ncbi Functional impairment as a predictor of spine loading
    William S Marras
    Biodynamics Laboratory, Ohio State University, Columbus, OH 43210, USA
    Spine (Phila Pa 1976) 30:729-37. 2005
    ..Spine loadings during a variety of lifting exertions were compared with individual torso kinematic abilities. Relationships were evaluated between these measures...
  86. ncbi Failure to use movement in postural strategies leads to increased spinal displacement in low back pain
    Nicola W Mok
    Division of Physiotherapy, University of Queensland, Brisbane, Queensland, Australia
    Spine (Phila Pa 1976) 32:E537-43. 2007
    ..Lumbar and hip movements, before and in response to rapid bilateral arm flexion, were evaluated in 10 people with recurrent low back pain (LBP) and 10 matched control subjects when standing on a flat surface or short base...
  87. ncbi [The actual condition of musculoskeletal disorders of workers working at new special nursing homes for the aged in Osaka Prefecture--comparison of musculoskeletal disorder between manager's awareness and care workers' complaints by questionnaire survey]
    Kimiko Tomioka
    Department of Community Health and Epidemiology, Nara Medical School of Medicine, Kashihara City, Nara, Japan
    Sangyo Eiseigaku Zasshi 49:216-22. 2007
    ..For managers to grasp the actual condition of musculoskeletal disorders of workers working at the nursing homes for the aged, we recommend that care workers should have a special health examination for LBP...
  88. doi Metrics of whole-body vibration and exposure-response relationship for low back pain in professional drivers: a prospective cohort study
    Massimo Bovenzi
    Unità Clinica Operativa di Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Azienda Ospedaliero Universitaria Ospedali Riuniti di Trieste, Universita di Trieste, Centro Tumori, Via della Pieta 19, 34129, Trieste, Italy
    Int Arch Occup Environ Health 82:893-917. 2009
    ..The objective of this study was to investigate the relation between alternative measures of exposure to whole-body vibration (WBV) and low back pain (LBP) in professional drivers...
  89. doi The influence of preoperative back pain on the outcome of lumbar decompression surgery
    Frank S Kleinstück
    Spine Center, Schulthess Klinik, Zurich, Switzerland
    Spine (Phila Pa 1976) 34:1198-203. 2009
    ..Prospective study with 12-month follow-up...
  90. doi Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues
    Md Mizanur Rahman
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita di Milano, Via Celoria 10, 20133 Milano, Italy
    Vet Immunol Immunopathol 137:28-35. 2010
    ..These results suggest that ruminant forestomachs may mount a local acute phase reaction...
  91. ncbi The lumbar spine and low back pain in golf: a literature review of swing biomechanics and injury prevention
    George S Gluck
    University of North Carolina at Chapel Hill, Department of Orthopedic Surgery, Chapel Hill, NC 27514, USA
    Spine J 8:778-88. 2008
    ..The golf swing imparts significant stress on the lumbar spine. Not surprisingly, low back pain (LBP) is one of the most common musculoskeletal complaints among golfers...
  92. ncbi A randomized controlled trial of transcutaneous electrical nerve stimulation (CODETRON) to determine its benefits in a rehabilitation program for acute occupational low back pain
    E Herman
    School of Occupational Therapy and Physiotherapy, McMaster University, Hamilton, Ontario
    Spine (Phila Pa 1976) 19:561-8. 1994
    ..Under the experimental conditions of this trial, no additional benefits of TENS/CODETRON were detected when added to an active exercise regimen...
  93. ncbi Massage for low-back pain: a systematic review within the framework of the Cochrane Collaboration Back Review Group
    Andrea D Furlan
    Institute for Work and Health, Toronto, Canada
    Spine (Phila Pa 1976) 27:1896-910. 2002
    ..Low back pain (LBP) is one of the most common and costly musculoskeletal problems in modern society. Proponents of massage therapy claim it can minimize pain and disability and speed return-to-normal function...
  94. ncbi Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Medical Univ of South Carolina, 280 Calhoun St, PO Box 250140, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 291:G456-63. 2006
    ..An absence of LBP blunts hepatocellular injury with decreased neutrophil infiltration, oxidative stress, and c-Jun and ERK activation...
  95. pmc Determinants for receiving acupuncture for LBP and associated treatments: a prospective cohort study
    Jean Francois Chenot
    Dpt, of General Practice, University of Gottingen, Humboldtallee 38, 37073 Goettingen, Germany
    BMC Health Serv Res 6:149. 2006
    ..Therefore, we explored factors associated with acupuncture treatment for LBP and the relation of acupuncture with other health care services...
  96. doi Causal assessment of awkward occupational postures and low back pain: results of a systematic review
    Darren M Roffey
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, 725 Parkdale Ave, Ottawa, ON K1Y 4E9, Canada
    Spine J 10:89-99. 2010
    ..Although numerous physical activities have been implicated in its complex etiology, determining causation remains challenging and requires a methodologically rigorous approach...
  97. doi A magnetic resonance imaging investigation of the transversus abdominis muscle during drawing-in of the abdominal wall in elite Australian Football League players with and without low back pain
    Julie A Hides
    Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Australia
    J Orthop Sports Phys Ther 40:4-10. 2010
    ..Single-blinded quasi-experimental study...
  98. doi A Cochrane review of combined chiropractic interventions for low-back pain
    Bruce F Walker
    Faculty of Health Sciences, School of Chiropractic and Sports Science, Murdoch University, Murdoch, Australia
    Spine (Phila Pa 1976) 36:230-42. 2011
    ..Cochrane systematic review of randomized controlled trials...
  99. ncbi Normative database for trunk range of motion, strength, velocity, and endurance with the Isostation B-200 Lumbar Dynamometer
    T Gomez
    Back Evaluation and Education Program, Workers Compensation Board of British Columbia, Richmond
    Spine (Phila Pa 1976) 16:15-21. 1991
    ..The normative database is reported in terms of descriptive statistics allowing comparison of future test results within the normal distribution and corrected for significant demographic features...
  100. ncbi Leg-length inequality in people of working age. The association between mild inequality and low-back pain is questionable
    A Soukka
    Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland
    Spine (Phila Pa 1976) 16:429-31. 1991
    ..78 (95% confidence interval, 0.43-1.17) and 1.02 (0.68-1.38), respectively, for an increase of 5 mm in leg-length inequality. The results from this study make an association between mild leg-length inequality and LBP questionable...
  101. ncbi [Evaluation of cicletanine efficiency and tolerance in hypertensive patients treated with beta-blockaders]
    P Clerson
    AMPLS, Wattrelos
    Arch Mal Coeur Vaiss 82:1293-7. 1989
    ..At the end of this study the percentage of patients whose BP was normalized was respectively for groups I, II and III: 5 p. 100, 51 p. 100 and 74 p. 100. Clinical and biological tolerance were good.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants70

  1. Helene M Langevin; Fiscal Year: 2015
    ..This study aims to establish a basic mechanism common to manual and movement-based therapies that will strengthen the rationale for these treatments. ..
  2. LINDA R VANDILLEN; Fiscal Year: 2016
    ..In addition, the approach described could be used to study other similarly long-term, costly, and function-limiting musculoskeletal pain conditions. ..
  3. Recurrent Low Back Pain: Linking Mechanisms to Outcomes
    Sheri P Silfies; Fiscal Year: 2010
    ....
  4. Gram-Negative Pneumonia and Lipopolysaccharide Binding Protein
    MARK RICHARD HEMMILA; Fiscal Year: 2010
    ..on the pathogenesis of Gram-negative bacterial pneumonia, specifically with respect to the role of lipopolysaccharide binding protein (LBP). LBP is an acute phase protein that recognizes the lipid A moiety of LPS...
  5. XV INTERNATIONAL CONGRESS OF NUTRITION
    RICHARD ALLISON; Fiscal Year: 1993
    ..b>Lipopolysaccharide binding protein(LBP), a recently described acute phase protein, is the key component of a novel pathway in which ..
  6. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    ..2 will characterize the association of systemic inflammation, measured by levels of TNF-1, TGF-21, Lipopolysaccharide binding protein (LBP), and C-Reactive Protein (CRP), with the development of NAFLD, and the intestinal microbiome...
  7. Chandrashekhar R Gandhi; Fiscal Year: 2016
    ..Such understanding is expected to highlight future avenues in developing effective treatment options, particularly in blocking the responses of HSCs to LPS or the specific signaling pathways responsible for hepatocyte injury. ..
  8. MENG CARLA WANG; Fiscal Year: 2016
    ..These studies will yield new insights to the molecular mechanisms by which lipid metabolism affects the aging process, and also provide novel therapeutic targets to improve metabolic health in elderly. ..
  9. Jerrold Weiss; Fiscal Year: 2014
    ..Knowledge of the molecular and cellular rules regulating TLR4 function contributes to the understanding of what determines the nature and the strength of TLR4-dependent responses in settings including, but not limited to, GNB infection. ..
  10. Timothy R Billiar; Fiscal Year: 2016
    ..This, in turn, could lead to strategies that promote LPS clearance and improve outcomes in critically ill septic patients. ..
  11. Epithelial Cell Bactercidal/Permeability Increasing Protein in Lung Injury
    Joan G Clark; Fiscal Year: 2010
    ..wall component, lipopolysaccharide (LPS), through interaction with TLR4 in conjunction with sCD14, MD2 and LPS binding protein. The cellular inflammatory response to LPS may be further modulated by Bactercidal/Permeability Increasing ..
  12. Regulation of MD-2 function and expression
    Jerrold P Weiss; Fiscal Year: 2013
    ..MD-2 complexes that activate TLR4;and 3) Better define in vivo actions in the murine airway of wt and variant E(lipdA).Md-2. ..
  13. Antibacterial and anti-inflammatory activities of Parotid Secretory Protein
    Sven Ulrik Gorr; Fiscal Year: 2013
    ..Thus, the research proposed here will lay the foundation for future translational research aimed at novel clinical approaches to combat infection and control inflammation. ..
  14. Defining non-transcriptional innate immune responses to bacterial endotoxin
    Jonathan C Kagan; Fiscal Year: 2013
    ..Collectively, this work will provide important insight into the means by which non-transcriptional responses to LPS are controlled. ..
  15. TRAUMA & ORGAN FAILURE--ROLE OF LPS BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2000
    ..This information will provide important and previously unavailable insights into post-traumatic responses to Gram-negative sepsis and endotoxemia. ..
  16. WOUND RESPONSE TO INFECTION: ROLE OF LPS-BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2003
    ..b>Lipopolysaccharide binding protein (LBP) is a potent facilitator of these functions and the investigators have found high levels of LBP ..
  17. STRUCTURE AND AFFINITY--CALCULATING LIPID SELECTIVITY
    Thomas Woolf; Fiscal Year: 2001
    ..A dialogue between the computational and the experimental will expand the range of connections in the LBP superfamily beyond what would be possible for any group acting in isolation. ..
  18. ANDREW K FOLICK; Fiscal Year: 2015
    ....
  19. Rapid, Point-of-Care Diagnosis of Neonatal Sepsis
    GREGORY SOMMER; Fiscal Year: 2013
    ..The company anticipates penetration into the estimated $1.5 billion global clinical neonatal and pediatric monitoring market within 4 years. ..
  20. John W Burns; Fiscal Year: 2015
    ..In addition, results may suggest interventions that could directly target common pain modulatory mechanisms underlying these predictive factors. ..
  21. Diagnostic Biomarkers for Radicular Pain
    GAETANO JOHN SCUDERI; Fiscal Year: 2010
    ..In addition, Cytonics will obtain invaluable information on disease pathogenesis and biochemical targets for the expeditious development of a next generation diagnostic assay and pharmacotherapeutic(s). ..
  22. Dynamic Lumbar-Pelvic Coordination in the Low Back During Lifting
    Sara E Wilson; Fiscal Year: 2013
    ....
  23. Aging, Neuromuscular Behavior, and Risk of Occupational Low Back Pain
    Babak Bazrgari; Fiscal Year: 2013
    ..By quantifying age-related alterations in TMB and the resultant effects on spine biomechanics, we expect to establish a foundation from which to develop and implement age-appropriate controls for LBP. ..
  24. Z Joint Changes in Low Back Pain Following Adjusting
    Gregory Cramer; Fiscal Year: 2009
    ..The results of this study will be used to increase understanding of the mechanism of action of lumbar side posture adjusting and side-posture positioning in acute LBP patients. ..
  25. Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
    Stefano Guerra; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Peter T Nelson; Fiscal Year: 2014
    ..The primary cel culture system will offer an experimental paradigm for testing novel methods of attenuating the dimorphic expression of miR-497 that drives alpha-SN expression. ..
  27. MOLECULAR BASIS OF CELL ACTIVATION IN SEPTIC SHOCK
    Jiing Dwan Lee; Fiscal Year: 1999
    ..The discovery that LPS, when complexed to the plasma protein, LPS binding protein (LBP), binds to membrane bound CD14 (mCD14) and that a consequence of this interaction is cell activation, ..
  28. Strain-Dependent Glucose Transport and Metabolism in Intervertebral Disc
    ALICIA RENEE JACKSON; Fiscal Year: 2010
    ..The outcome of these studies will provide insight into the etiological causes of disc degeneration and LBP and may also be used in the development of new strategies for treatment of LBP. ..
  29. Dose-Response/Efficacy of Manipulation for Chronic LBP
    Mitchell Haas; Fiscal Year: 2010
    ....
  30. Diagnostic Biomarkers for Radicular Pain
    Lewis S Hanna; Fiscal Year: 2012
    ....
  31. Gregory E Hicks; Fiscal Year: 2016
    ....
  32. Neurobiological Mechanisms of Body Based Intervention for Musculoskeletal Pain
    Mark D Bishop; Fiscal Year: 2012
    ..This means that most of the other things associated with back pain like the type of injury, the time after injury, or patients'emotional and psychological state can be accounted for when testing a treatment. ..
  33. Comparative Effectiveness of Management Strategies for Acute Low Back Pain
    Julie M Fritz; Fiscal Year: 2013
    ..The results of this study will help to determine the most effective management strategies about which care should be standardized. ..
  34. A Comparison of Manual VS. Mechanical Chiropractic Manipulation Methods
    Michael J Schneider; Fiscal Year: 2012
    ..abstract_text> ..
  35. Bruce S Weir; Fiscal Year: 2016
    ..Genetic, physiological, psychological and clinical characteristics will be measured to determine why pain becomes persistent, and why some people develop multiple of these chronic pain conditions. ..
  36. Connective Tissue Motion Measure 2
    Robert T Davis; Fiscal Year: 2013
    ..This will not alter device performance, rather it will reduce estimated manufacturing costs of these subsystems significantly. Upgraded device performance will be verified to match existing specifications. ..
  37. James S Thomas; Fiscal Year: 2016
    ..abstract_text> ..
  38. Mechanisms of specific trunk Exercises in low back pain
    Sharon M Henry; Fiscal Year: 2010
    ..This series of experiments will, for the first time, compare two classification systems used in LBP treatment and determine if they are superior to STC exercises. 4 ..
  39. Reducing Low-back Disorders Using a New Sitting Design
    Mohsen Makhsous; Fiscal Year: 2003
    ..abstract_text> ..
  40. Mark D Bishop; Fiscal Year: 2015
    ..Identifying these therapies will improve management of chronic musculoskeletal pain conditions reducing the impact of LBP on healthcare and society. ..
  41. Biomechanical and Neurophysiological Effects of Spinal Manipulative Therapy
    Julie Fritz; Fiscal Year: 2009
    ....
  42. NORMAN PETER REEVES; Fiscal Year: 2016
    ..Using a cross-over experimental design, these tools will then be applied to measure changes in position and force control of the head-neck system in patients with and without neck pain before and after 4 weeks of OMT. ..
  43. Software for cost-benefit analysis of LBP interventions
    Nancy Nelson; Fiscal Year: 2006
    ..The software will encourage adoption of methods for preventing occupational low back disorders. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain
    Helene M Langevin; Fiscal Year: 2010
    ....
  45. LPS and Monocyte Activation in HIV Neuropathogenesis
    Dana Gabuzda; Fiscal Year: 2009
    ..The studies will also provide information that could help to identify new potential therapeutic strategies for HIV/AIDS. ..
  46. Care Choices and Costs for Low Back Pain
    Sylvia Kuo; Fiscal Year: 2006
    ..Such strategies may help reduce the health care expenditures associated with LBP. The findings from this proposed research will lead to a larger study which would examine outcomes and costs. [unreadable] [unreadable] [unreadable]..
  47. Acupuncture and Low Back Pain during Pregnancy
    Shu Ming Wang; Fiscal Year: 2007
    ..abstract_text> ..
  48. Angela Renee Starkweather; Fiscal Year: 2015
    ..Therefore, the proposed study will investigate the role of enhanced pain sensitivity on the risk of persistent LBP through characterization of pain sensitivity and pain-sensitivity candidate gene profiling. ..
  49. LEUKOCYTE INTERACTIONS WITH EXTRACELLULAR MATRIX
    ARTHUR MERCURIO; Fiscal Year: 1999
    ....
  50. SURFACTANT PROTEINS AND LUNG INFLAMMATION
    Kelly Greene; Fiscal Year: 2000
    ..These studies combine clinically oriented studies in patients with ARDS with basic studies of new mechanisms by which surfactant proteins may modulate inflammation in the lung. ..
  51. Mechanisms and Effects of Chiropractic Manipulation
    William Meeker; Fiscal Year: 2006
    ..It will provide the focus and direction to synergistically increase the "critical mass" of personnel and resources to address an important unmet public health need. ..
  52. LBP/CD14 interactions with bacterial components
    Richard Darveau; Fiscal Year: 2005
    ..These studies will provide further insight into how the innate host defense system recognizes and responds to different bacteria, a key component of both oral health and disease. ..
  53. The Mechanism and Function of Lumbosacral Orthoses
    Jacek Cholewicki; Fiscal Year: 2006
    ..In addition, data generated from the proposed research will also carry-over into advancing our understanding of the mechanisms and function of ergonomic lumbar supports. ..
  54. PROTEIN SECRETION IN PARASITIC NEMATODES
    Patricia Komuniecki; Fiscal Year: 1999
    ..On a broad scale, the investigators intend to determine whether nematodes can be engineered to secrete specific proteins during specific stages in their life cycles. ..
  55. Increasing Fruits, Vegetables, and Whole Grains in Preschool Sack Lunches
    MARGARET BRILEY; Fiscal Year: 2009
    ..abstract_text> ..
  56. NATURAL HISTORY OF ACUTE LOW BACK PAIN/RADICULOPATHY
    Michael Modic; Fiscal Year: 2001
    ..In addition the authors are hypothesizing that any reduction in anxiety or reassurance associated with knowledge of MRI findings is not cost- effective. ..
  57. PHAGOCYTE RECEPTORS FOR LIPID A
    Douglas Golenbock; Fiscal Year: 2007
    ..In addition, we will challenge this knockout animal with Salmonella to determine if and hot TRAM expression contributes to host defense. [unreadable] [unreadable]..
  58. LBP with Radiculopathy: An Inflammatory Response
    JOYCE DELEO; Fiscal Year: 2005
    ..This new knowledge will guide development of novel, non-addictive preventive therapies and treatments for chronic low back pain. ..
  59. Role of LBP-1a and p14 NF-E4 in gamma globin gene expre*
    STEPHEN JANE; Fiscal Year: 2004
    ..Finally, through protein interaction studies they may identify additional novel factors important in the activation (or repression) of gamma-globin gene expression. ..
  60. Objective Assessment Instrumentation for Manual Therapy Techniques
    SUSAN DIEKRAGER; Fiscal Year: 2009
    ....
  61. ANALYSIS OF M CATARRHLIS RECEPTORS AS VACCINE ANTIGENS
    ANTHONY CAMPAGNARI; Fiscal Year: 2003
    ..2) To delineate membrane topography of each receptor and define antigenic domains. (3) To analyze and characterize the human antibody response, elicited in vivo, to each specific receptor. ..
  62. LUNG LPS BINDING PROTEIN AND ARDS AFTER TRAUMA
    Richard Klein; Fiscal Year: 2000
    ..b>Lipopolysaccharide binding protein (LBP), found in serum and produced locally, enhances the binding of LPS to CD14 receptor...
  63. MOLECULAR PATHOLOGY OF LPS INDUCED SHOCK AND DIC
    Richard Ulevitch; Fiscal Year: 2000
    ..In blood LPS forms a high affinity complex with a plasma protein we discovered; lipopolysaccharide binding protein (LBP) and the LPS-LBP complex binds to the plasma membrane of MO via a receptor that we have ..
  64. MOLECULAR PATHOLOGY OF PHAGOCYTOSIS IN SEPSIS
    Deborah Schiff; Fiscal Year: 2000
    ..Information obtained from these studies will help answer important questions pertaining to CD14 and its role in host defense, and may contribute to the development of new strategies for the treatment of Gram-negative infections. ..
  65. Motor Control Deficit in Low Back Pain: Cause or Effect?
    Jacek Cholewicki; Fiscal Year: 2003
    ..The results of the proposed research will have a significant clinical relevance for designing more effective prevention, diagnosis, and rehabilitation strategies for LBP. ..
  66. MODULATION OF AIRWAY INFLAMMATION IN ASTHMA MODELS
    David Center; Fiscal Year: 2005
    ..through the use of LBP-/-, CD14-/-, and TLR4-/- mice and seeks to determine why aerosol antigen challenged LPS binding protein (LBP)-/- mice lack airway hyper-reactivity (AHR) nitric oxide (NO) production. Project 3 is a renewal of Dr...
  67. ACTIVE CONFORMATION OF LAMININ PEPTIDE 11
    Jean Starkey; Fiscal Year: 1999
    ..Other experiments will evaluate the postulate that the 67 kDa LBP may act in concert with the a6b1 integrin during tissue invasion. ..
  68. SF-1 INDEPENDENT TRANSCRIPTIONAL REGULATION OF P450SCC
    Ningwu Huang; Fiscal Year: 2005
    ..Completion of these aims will provide new information about the nature of SF-1-independent placental transcription of the human P450scc gene...
  69. Workers' Compensation Internet Low Back Pain Study
    Kate Lorig; Fiscal Year: 2001
    ..The intervention has the potential of improving health-related quality of life and reducing days lost from work and health care utilization. It is low-cost and easily replicable. ..
  70. BIOCHEMICAL MECHANISMS OF CELLULAR INJURY IN TRAUMA
    Richard Ulevitch; Fiscal Year: 2006
    ..Grant have provided seminal findings that led to the appreciation of the importance of two proteins, LPS binding protein (LBP) and CD14, in the initiation of these host responses to LPS...