LIPG

Summary

Gene Symbol: LIPG
Description: lipase G, endothelial type
Alias: EDL, PRO719, endothelial lipase, endothelial cell-derived lipase, lipase, endothelial, lipoprotein lipase H
Species: human

Top Publications

  1. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
  2. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
  3. ncbi Characterization of the lipolytic activity of endothelial lipase
    Mary G McCoy
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 43:921-9. 2002
  4. pmc Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
  5. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
  6. ncbi The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, Pavillon Paul Comtois, Office 2423, Laval University, Quebec G1K 7P4, Canada
    J Lipid Res 44:1902-8. 2003
  7. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
  8. ncbi Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
    Cyrille Maugeais
    Departments of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 108:2121-6. 2003
  9. ncbi Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins
    Uli C Broedl
    University of Pennsylvania, Philadelphia, PA, USA
    Circ Res 94:1554-61. 2004
  10. ncbi Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation
    Yoko Kojma
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:54032-8. 2004

Research Grants

  1. Kiran Musunuru; Fiscal Year: 2016
  2. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2012
  3. Hong Wang; Fiscal Year: 2016
  4. DANIEL JAMES RADER; Fiscal Year: 2016
  5. Endothelial lipase: a modulator of HDL metabolism and atherosclerosis in humans
    ANDREW CHARLES EDMONDSON; Fiscal Year: 2010
  6. Novel Modulators of HDL Metabolism
    Nabil A Elshourbagy; Fiscal Year: 2013
  7. Endothelial Lipase: a novel therapeutic target for HDL and atherosclerosis
    XIAOMIN contact FAN; Fiscal Year: 2010
  8. Temporal and Spatial patterns of structural proteins in extraocular muscles
    CAROLE MONCMAN; Fiscal Year: 2009
  9. R Graham Barr; Fiscal Year: 2014
  10. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013

Detail Information

Publications204 found, 100 shown here

  1. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
    ..other family members, this new lipase is synthesized by endothelial cells in vitro and thus has been termed endothelial lipase (encoded by the LIPG gene)...
  2. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
    ..Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease...
  3. ncbi Characterization of the lipolytic activity of endothelial lipase
    Mary G McCoy
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 43:921-9. 2002
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity...
  4. pmc Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
    Endothelial cell-derived lipase (EDL) is a new member of the lipase gene family with high sequence homology with lipoprotein lipase (LPL). EDL is a phospholipase with very little triacylglycerol lipase activity...
  5. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    High-density lipoprotein (HDL) protects against atherosclerosis. Endothelial lipase (EL) has been postulated to be involved in lipoprotein, and possibly HDL, metabolism, yet the evidence has been scarce and conflicting...
  6. ncbi The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, Pavillon Paul Comtois, Office 2423, Laval University, Quebec G1K 7P4, Canada
    J Lipid Res 44:1902-8. 2003
    The objective of the present study was to examine the impact of the T111I missense mutation in exon 3 of the endothelial lipase (EL) gene on HDL and its potential interaction effect with dietary fat...
  7. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism...
  8. ncbi Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
    Cyrille Maugeais
    Departments of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 108:2121-6. 2003
    ..Overexpression of endothelial lipase (EL) markedly reduces plasma levels of HDL cholesterol and apoA-I in mice, but the mechanisms of this effect ..
  9. ncbi Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins
    Uli C Broedl
    University of Pennsylvania, Philadelphia, PA, USA
    Circ Res 94:1554-61. 2004
    b>Endothelial lipase (EL) has been found to be a key enzyme in high-density lipoprotein (HDL) metabolism in mice, leading to the concept that inhibition of EL could be a novel strategy for raising HDL cholesterol levels...
  10. ncbi Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation
    Yoko Kojma
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:54032-8. 2004
    b>Endothelial lipase (EL), a new member of the lipoprotein lipase gene family, plays a central role in high density lipoprotein metabolism...
  11. ncbi Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
    The LIPG gene on chromosome 18 encodes for endothelial lipase, a member of the triglyceride lipase family...
  12. ncbi Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 47:2581-8. 2006
    ..The placental triglyceride (TG) concentration and mRNA expression of endothelial lipase (EL) and hormone-sensitive lipase (HSL) were increased in placentas from women with diabetes...
  13. ncbi Endothelial lipase is associated with inflammation in humans
    Marie Eve Paradis
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
    J Lipid Res 47:2808-13. 2006
    The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men...
  14. ncbi Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies
    M Gauster
    Institute of Histology, Cell Biology, and Embryology, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, Graz, Austria
    J Clin Endocrinol Metab 92:2256-63. 2007
    ..Fetal supply of maternally derived fatty acids requires lipase-mediated hydrolysis of lipoprotein-borne triglycerides and phospholipids at the placental surface...
  15. ncbi Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
    Masakatsu Shimizu
    Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ J 71:842-6. 2007
    b>Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment...
  16. ncbi Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    Na Ping Tang
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
    J Lipid Res 49:369-75. 2008
    The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) ..
  17. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Animal models indicate that decreased expression of endothelial lipase (LIPG) is inversely associated with HDL-C levels, and genome-wide association studies have identified LIPG ..
  18. pmc Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, United States
    Atherosclerosis 206:500-4. 2009
    ..HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG).
  19. pmc The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations
    Majken K Jensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Eur Heart J 30:1584-9. 2009
    b>Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C)...
  20. pmc Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation
    Nathalie Griffon
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:23322-30. 2009
    b>Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase...
  21. doi Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  22. doi Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:558-64. 2010
    ..b>Endothelial lipase is involved in HDL-C metabolism...
  23. doi Role of endothelial lipase in atherosclerosis
    Ji Huang
    Emergency Center of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital University of Medical Sciences and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, P R China
    Transl Res 156:1-6. 2010
    b>Endothelial lipase, which is a newly identified member of the lipase family, plays an important role in high-density lipoprotein metabolism, which catalyzes the hydrolysis of high-density lipoprotein phospholipids and facilitates the ..
  24. doi Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells
    Annukka M Kivelä
    The Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, Neulaniementie 2, FIN 70211 Kuopio, Finland
    Atherosclerosis 213:122-8. 2010
    b>Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis...
  25. pmc Association of the LIPG 584C > T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Wan Ying Liu
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:110. 2010
    b>Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism, but the association of endothelial lipase gene (LIPG) polymorphism and serum HDL-C levels is scarce and conflicting in diverse ..
  26. pmc Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
    ..haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL), consistent with its role in HDL-C catabolism...
  27. ncbi The association between endothelial lipase -384A/C gene polymorphism and acute coronary syndrome in a Chinese population
    Gaojun Cai
    Department of Cardiology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, Jiangsu Province, People s Republic of China
    Mol Biol Rep 39:9879-84. 2012
    b>Endothelial lipase (EL) is a novel member of the triglyceride (TG) lipase family. A growing body of evidence has indicated that EL gene polymorphism might contribute to the process of cardiovascular diseases...
  28. doi The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans
    Roshni R Singaraja
    Xenon Pharmaceuticals Inc, Burnaby, Canada
    Circ Cardiovasc Genet 6:54-62. 2013
    b>Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although a small number of mutations in LIPG have been described, the role of LIPG in protection against atherosclerosis is unclear.
  29. doi Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase
    Niels Nijstad
    Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 284:6093-100. 2009
    b>Endothelial lipase (EL) is a negative regulator of high density lipoprotein (HDL) cholesterol plasma levels, and scavenger receptor BI (SR-BI) is involved in remodeling of HDL...
  30. ncbi Insulin resistance and hypertension: in vivo and in vitro insulin action in skeletal muscle in spontaneously hypertensive and Wistar-Kyoto rats
    A L Swislocki
    Medical Service, Department of Veterans Affairs Northern California Health Care System, Martinez 94533, USA
    Am J Hypertens 10:1159-64. 1997
    ..increased from 377 +/- 120 to 439 +/- 175 disintegrations per minute (dpm) 3H-glucose/mg extensor digitorum longus (EDL) in WKY when insulin increased from 0 to 1000 microU/mL (P < ...
  31. pmc Acute effects of the beta 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilisation
    Y L Liu
    Department of Physiology, St George s Hospital Medical School, Tooting, London
    Br J Pharmacol 114:888-94. 1995
    ..and potentiated the response in Type II (non-working) muscles such as tibialis and extensor digitorium longus (EDL). 4...
  32. ncbi Dissociation between insulin binding and glucose utilization after intense exercise in mouse skeletal muscles
    A Bonen
    Department of Physiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Horm Metab Res 21:172-8. 1989
    ..2-deoxy-d-glucose (2-DOG) uptake and glucose incorporation into glycogen and glycolysis were compared in soleus and EDL muscles of intensively exercised (2-3 h) mice and non-exercised mice...
  33. pmc Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase
    Luis Da Silva-Azevedo
    Department of Physiology, Charite Campus Benjamin Franklin, Arnimallee 22, Berlin Dahlem, Germany
    J Physiol 587:655-68. 2009
    ..subsequent tandem mass spectrometry (LC-MS/MS) was performed using extracts of extensor digitorum longus muscle (EDL) derived from nNOS-knockout mice in comparison to C57Bl/6 control mice...
  34. ncbi Skeletal muscle myosin heavy chain expression in rats with monocrotaline-induced cardiac hypertrophy and failure. Relation to blood flow and degree of muscle atrophy
    G Vescovo
    First Division of Internal Medicine, Venice City Hospital, Italy
    Cardiovasc Res 39:233-41. 1998
    ..In congestive heart failure (CHF) the skeletal muscle of the lower limbs develops a myopathy characterised by atrophy and shift from the slow to the fast type fibres. The mechanisms responsible for these changes are not clear yet...
  35. pmc Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation
    M C Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Physiol Regul Integr Comp Physiol 298:R2-8. 2010
    ..Intact extensor digitorum longus (EDL) and soleus muscles from mice were also incubated in vitro with oxypurinol or polyethylene glycol-tagged Cu,Zn-SOD...
  36. ncbi Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway
    Ilia V Fuki
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:34331-8. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family, which includes lipoprotein lipase (LpL) and hepatic lipase (HL). Enzymatic activity of EL has been studied before...
  37. pmc Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 139:291-304. 2011
    b>Endothelial lipase (gene: LIPG; enzyme: EL) is one of three members of the triglyceride lipase family that contributes to lipoprotein degradation within the circulation system and plays a major role in HDL metabolism in the body...
  38. ncbi Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins
    Daniela Caiazza
    Lipid Research Group, The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia
    Biochemistry 43:11898-905. 2004
    b>Endothelial lipase (EL) is a newly identified member of the triglyceride lipase gene family that hydrolyzes high-density lipoprotein (HDL) phospholipids...
  39. ncbi In vitro 1H-NMR spectroscopic analysis of metabolites in fast- and slow-twitch muscles of young rats
    Yoshichika Yoshioka
    Department of Physiology II, School of Medicine, Iwate Medical University, Morioka, Japan
    Magn Reson Med Sci 1:7-13. 2002
    ..TAU), anserine (ANS) and carnosine (CAR) content of the masseter muscles (MM), long extensor muscles of digits (EDL) and soleus muscles (SOL) of young rats were determined using in vitro 1H-NMR spectroscopy to assess the ..
  40. pmc Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    b>Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models...
  41. ncbi Differences in glucose transport rates between perfused and in vitro incubated muscles
    M Kern
    Department of Biochemistry, East Carolina University, School of Medicine, Greenville, North Carolina
    Horm Metab Res 22:366-8. 1990
    ..3-O-Methylglucose transport rates in incubated soleus (SOL) and extensor digitorum longus (EDL) muscle strips were compared to transport rates obtained in SOL and EDL muscles removed from perfused hindquarters...
  42. ncbi Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model
    Nobukazu Takahashi
    Division of Diagnostic Imaging, Box 57, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Acad Radiol 14:1050-7. 2007
    ..We previously have reported that (99m)Tc-labeled glutamate peptide-estradiol ((99m)Tc-GAP-EDL) is a useful agent for imaging functional estrogen receptor (ER) via an ER-mediated process...
  43. doi Electrostatic and electrochemical nature of liquid-gated electric-double-layer transistors based on oxide semiconductors
    Hongtao Yuan
    Quantum Phase Electronics Center and Department of Applied Physics, The University of Tokyo, Tokyo 113 8656, Japan
    J Am Chem Soc 132:18402-7. 2010
    The electric-double-layer (EDL) formed at liquid/solid interfaces provides a broad and interdisciplinary attraction in terms of electrochemistry, photochemistry, catalysts, energy storage, and electronics because of the large interfacial ..
  44. pmc Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat
    Robyn M Murphy
    Department of Zoology, La Trobe University, Melbourne, Victoria, Australia
    J Physiol 587:443-60. 2009
    ..the absolute amount of CSQ isoform 1 (CSQ1, the primary isoform) present in rat extensor digitorum longus (EDL) and soleus fibres, and related this to their endogenous and maximal SR Ca2+ content...
  45. ncbi Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse
    Tatiana L Radzyukevich
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 287:C1445-52. 2004
    ..After 14-day simultaneous denervation of the soleus (Sol), tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius (Gastr) muscles by sciatic nerve section, DHPR mRNA increased preferentially in the Sol and TA (..
  46. ncbi Acute effects of N-acetylcysteine on skeletal muscle microcirculation following closed soft tissue trauma in rats
    Klaus D Schaser
    Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Orthop Res 23:231-41. 2005
    ..Microcirculation of the extensor digitorum longus (EDL) muscle was analyzed using intravital microscopy and Laser-Doppler flowmetry (LDF)...
  47. doi Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors
    Tu Nguyen-Huu
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité Propre de Recherche 9040, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Anesthesiology 110:1011-5. 2009
    ..The basis of this difference may be a higher concentration of acetylcholine released or higher number of postsynaptic nicotinic acetylcholine receptors in diaphragmatic neuromuscular junctions...
  48. ncbi Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis
    Claire Thomas
    Universite Montpellier 1, UFR Médecine EA701, F 34295, Montpellier, France
    Am J Physiol Endocrinol Metab 293:E916-22. 2007
    ..MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles...
  49. pmc Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism
    Gentian Lluri
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Neurobiol 66:1365-77. 2006
    ..report that TIMP-2 is expressed at the NMJ and its expression is greater in fast-twitch (extensor digitorum longus, EDL) than slow-twitch (soleus) muscle...
  50. ncbi Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation
    Blake C Beehler
    Cardiovascular and Metabolic Diseases Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08543, USA
    Exp Biol Med (Maywood) 231:335-41. 2006
    ..At the end of the study, the rats were euthanized and the soleus and extensor digitorum longus (EDL) muscles were harvested. In vehicle-treated rats, denervation caused a 33.5 +/- 2.8% and 16.2 +/- 2...
  51. doi Myofascial force transmission via extramuscular pathways occurs between antagonistic muscles
    Peter A Huijing
    Research Instituut Move, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Cells Tissues Organs 188:400-14. 2008
    ..force was measured simultaneously at: (1) the proximal and distal tendons of the extensor digitorum muscle (EDL) to quantify any proximo-distal force differences, as an indicator of myofascial force transmission, (2) at the ..
  52. pmc Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels
    A De Luca
    Dipartimento Farmacobiologico, Facolta di Farmacia, Universita di Bari, Italy
    Br J Pharmacol 125:477-82. 1998
    ..2. For this purpose G(Cl) in EDL muscle isolated from adult rat was first lowered by treatment with 5 nM 4-beta-phorbol 12,13 dibutyrate (4-beta-PDB)..
  53. ncbi Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration
    Oliver Baum
    Department of Anatomy and Physiology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Königin Luise Str 15, D 14195 Berlin Dahlem, Germany
    Am J Physiol Heart Circ Physiol 287:H2300-8. 2004
    ..of capillaries/mm2) were determined in frozen sections from extensor digitorum longus (EDL) muscles of these mice...
  54. ncbi Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles
    F Yu
    Noll Physiological Research Center and Department of Cellular and Molecular Physiology, Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    Am J Physiol Regul Integr Comp Physiol 278:R1545-54. 2000
    ..In fast-twitch extensor digitorum longus (EDL) muscle, TR-alpha(1)-, TR-beta-, or TR-alpha(1)beta-deficient mice showed a small but statistically significant ..
  55. pmc Protein diffusion in living skeletal muscle fibers: dependence on protein size, fiber type, and contraction
    S Papadopoulos
    Department of Physiology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Biophys J 79:2084-94. 2000
    ..were injected into single, intact skeletal muscle fibers taken from either soleus or extensor digitorum longus (edl) muscle of adult rats...
  56. ncbi 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora
    Yongping Cao
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Kita gun Kagawa 761 0793, Japan
    Bone 40:132-9. 2007
    ....
  57. pmc Acute molecular response of mouse hindlimb muscles to chronic stimulation
    W A Laframboise
    Dept of Pathology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Shadyside Hospital West Wing, WG02 11, 5230 Center Ave, Pittsburgh, PA 15232, USA
    Am J Physiol Cell Physiol 297:C556-70. 2009
    ..An immediate-early growth response was present in the extensor digitorum longus (EDL) muscle (FOS, JUN, activating transcription factor 3, and musculoaponeurotic fibrosarcoma oncogene) with a similar ..
  58. ncbi Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres
    Petra Wetzel
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany, Wetzel
    Pflugers Arch 443:762-70. 2002
    Muscle carbonic anhydrase (CA) was inhibited in fibre bundles of the extensor digitorum longus (EDL) and soleus (SOL) muscles from rats. Isometric single twitches were recorded in the absence or presence of the CA inhibitors...
  59. ncbi Vinculin and meta-vinculin in fast and slow rat skeletal muscle before and after hindlimb suspension
    Angèle Chopard
    Laboratoire de Physiologie Cellulaire et Moléculaire Des Systèmes Intégrés, CNRS, Unité Mixte de Recherche 6548, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Pflugers Arch 444:627-33. 2002
    ..the expression of these proteins in a slow-twitch (soleus) and in a fast-twitch (extensor digitorum longus, EDL) skeletal muscle under control conditions and after a reduced functional demand...
  60. doi Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle
    Milan Holecek
    Department of Physiology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    Amino Acids 40:575-84. 2011
    ..M. soleus (SOL, slow-twitch, red muscle) and m. extensor digitorum longus (EDL, fast-twitch, white muscle) of white rat were isolated and incubated in a medium with or without 500 μM ammonia...
  61. ncbi A comparison of the electrophysiological effects of two organophosphates, mipafox and ecothiopate, on mouse limb muscles
    G E de Blaquière
    Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, United Kingdom
    Toxicol Appl Pharmacol 150:350-60. 1998
    ..Acetylcholinesterase activity was measured in the soleus (slow-twitch) and extensor digitorum longus (EDL; fast-twitch) muscles...
  62. ncbi Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I
    A Jahangiri
    Lipid Research Group, Heart Research Institute, Camperdown, Sydney, New South Wales 2050, Australia
    J Lipid Res 46:896-903. 2005
    b>Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity...
  63. ncbi Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
    ..The sedentary control animals remained in their cages. For each animal, Po was determined in the fast-twitch EDL and slow-twitch soleus muscles from one hindlimb and quantitative measurements of [Ca2+]i were made in the ..
  64. pmc Tetanus relaxation of fast skeletal muscles of the mouse made parvalbumin deficient by gene inactivation
    J M Raymackers
    Departement de Physiologie, Universite Catholique de Louvain, B 1200 Bruxelles, Belgium
    J Physiol 527:355-64. 2000
    The effects of tetanus duration on the relaxation rate of extensor digitorum longus (EDL) and flexor digitorum brevis (FDB) muscles were studied in normal (wild-type, WT) and parvalbumin-deficient (PVKO) mice, at 20 C...
  65. ncbi The relationship between skeletal muscle proteolysis and ubiquitin-proteasome proteolytic pathway in burned rats
    Jiake Chai
    Department of Burns and Plastic Surgery, Burns Institute, 304th Hospital, Beijing 100037, China
    Burns 28:527-33. 2002
    ..The proteolytic rates and mRNA expression of ubiquitin, E2-14K, and subunit RC2 in extensor digital longus (EDL) and soleus (SOL) muscle were determined by amino acid analyzer and Northern blot, respectively...
  66. ncbi Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage
    A Lionikas
    Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Genomics 16:141-52. 2003
    ..slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C57BL/6J (B6) than in DBA/2J (D2) mice...
  67. ncbi Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
    ..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
  68. ncbi Contractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II
    Matthew D Beekley
    Zentrum Physiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Pflugers Arch 452:453-63. 2006
    ..Because of this, we compared the in vitro contractile properties of extensor digitorum longus (EDL) and soleus (SOL) fibre bundles from mice deficient in CA II (CAD) to litter mate controls (LM)...
  69. pmc Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice
    G J Etgen
    Pfizer Central Research, Eastern Point Road, Groton, CT 06340, USA
    Biochem J 337:51-7. 1999
    ..mannos-4-yloxy)-2-propylamine photolabelling methodology in both isolated and perfused extensor digitorum longus (EDL). Cell-surface GLUT1 was enhanced by as much as 70-fold in both isolated and perfused EDL of transgenic mice...
  70. ncbi Decreased monocarboxylate transporter 1 in rat soleus and EDL muscles exposed to clenbuterol
    T Kitaura
    Faculty of Pharmaceutical Sciences, University of Kanazawa, Kakuma, Kanazawa 920 1192, Japan
    J Appl Physiol (1985) 91:85-90. 2001
    ..LDH) and isoform pattern and shift myosin heavy chain (MHC) pattern in soleus (Sol) and extensor digitorum longus (EDL) of male rats. In the clenbuterol-administered rats (2...
  71. ncbi Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
    J Exp Biol 205:2337-48. 2002
    ..type IIA fibres in normal rat soleus (N-SOL) muscle and of the type IIA fibres in extensor digitorum longus (N-EDL) muscle...
  72. ncbi Post-effects of nandrolone decanoate treatment on contractile responses of rat skeletal muscles
    Wissam H Joumaa
    Laboratoire de Physiologie Generale, CNRS UMR 6018, Faculte des Sciences et des Techniques, Universite de Nantes, B P 92208, 44322 Nantes, France
    Jpn J Physiol 52:479-87. 2002
    ..on contractile responses of isolated small bundles of intact slow-(soleus) and fast-(extensor digitorum longus, edl) twitch fibers in rat...
  73. ncbi Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles
    Cyril Bozzo
    Department of Anatomy and Physiology, University of Padova, Italy
    FEBS J 272:5771-85. 2005
    ..chains (MLC1) and regulatory myosin light chains (MLC2) in rat slow (soleus) and fast (extensor digitorum longus EDL) muscles using 2D-gel electrophoresis and mass spectrometry...
  74. doi Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
    J G Kemp
    1 School of Biomedical and Health Sciences, Victoria University, Footscray, Victoria, Australia
    Int J Obes (Lond) 33:831-41. 2009
    ..Knowledge of the morphological and biochemical alterations occurring in skeletal muscles of obese animals is relatively limited, particularly with respect to non-limb muscles and relationship to fibre type...
  75. doi Treating retinoblastoma in tissue culture and in a rat model with a novel isoquinoline derivative
    Mohamed Nassr
    Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Invest Ophthalmol Vis Sci 51:3813-9. 2010
    PURPOSE. To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblastoma in vitro and in vivo. METHODS...
  76. ncbi Myosin heavy chain expression in skeletal muscle autografts under neural or aneural conditions
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Surg Res 75:135-47. 1998
    ....
  77. ncbi Role of load bearing in acetylcholinesterase regulation in rat skeletal muscles
    Peter Pregelj
    Institute of Pathophysiology, School of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Neurosci Res 67:114-21. 2002
    ..The levels of AChE mRNA in the slow soleus muscles are about 30% of those in the fast extensor digitorum longus (EDL) muscles...
  78. pmc Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
    J Clin Microbiol 41:4930-40. 2003
    The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into five "seropathotypes" (A through E) based on the reported ..
  79. ncbi Mitochondrial superoxide production in skeletal muscle fibers of the rat and decreased fiber excitability
    Chris van der Poel
    Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Autralia
    Am J Physiol Cell Physiol 292:C1353-60. 2007
    ..responses were measured at 37 degrees C in mechanically skinned muscle fibers of rat extensor digitorum longus (EDL) muscle. In mechanically skinned fibers, the sarcolemma is removed avoiding potential sources of O(2)(...
  80. pmc Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice
    Benjamin T Corona
    Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, GA 30302 3975, USA
    J Appl Physiol (1985) 105:1542-53. 2008
    ..RYR1Y522S/wt) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (EDL) muscles] damage and strength deficits following the performance of a single or repeated bouts of eccentric ..
  81. pmc Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    Iulia Iatan
    Department of Biochemistry, Cardiovascular Research Laboratories, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 2:467-75. 2009
    ..HDL particles are modulated by a variety of lipases, including endothelial lipase, a phospholipase present on vascular endothelial cells...
  82. ncbi Muscle fiber type composition and morphometric properties of denervated rat extensor digitorum longus muscle
    D Bobinac
    Department of Anatomy, Rijeka University School of Medicine, Brace Branchetta 22, 51000 Rijeka, Croatia
    Croat Med J 41:294-7. 2000
    Analysis of fiber type composition and fiber size of extensor digitorum longus (EDL) muscle in rats during 30 days of denervation.
  83. ncbi Histochemical differences in the responses of predominantly fast-twitch glycolytic muscle and slow-twitch oxidative muscle to veratrine
    Erika Maria Silva Freitas
    Departamento de Histologia e Embriologia, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, 13083 970, Campinas, SP, Brazil
    Toxicon 40:1471-81. 2002
    ..alkaloid veratrine is able to change the oxidative and m-ATPase activities of a fast-twitch glycolytic muscle (EDL, extensor digitorum longus) and slow-twitch oxidative muscle (SOL, soleus) in mice...
  84. ncbi Metabolic modulation of muscle fiber properties unrelated to mechanical stimuli
    Yoshinobu Ohira
    School of Health and Sport Sciences and Graduate School of Medicine, Osaka University, Toyonaka, Osaka, 560 0043 Japan
    Jpn J Physiol 53:389-400. 2003
    ..and the morphological and metabolic properties of single fibers in the soleus and extensor digitorum longus (EDL) muscles in young rats were determined...
  85. doi Effects of 14 days of microgravity on fast hindlimb and diaphragm muscles of the rat
    Mark D Schuenke
    Department of Anatomy, College of Osteopathic Medicine, University of New England, 431 Stella Maris, Biddeford, NE 04005, USA
    Eur J Appl Physiol 106:885-92. 2009
    ..2000). Hindlimb muscles containing predominately fast fibers [extensor digitorum longus (EDL), superficial "white" (GSW) and deep "red" (GDR) gastrocnemius] and the diaphragm (DIA) were removed from flight ..
  86. pmc Excitation-induced exchange of Na+, K+, and Cl- in rat EDL muscle in vitro and in vivo: physiology and pathophysiology
    Torben Clausen
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Gen Physiol 141:179-92. 2013
    ..This study quantifies these changes in rat extensor digitorum longus (EDL) muscles in vitro and in vivo using flame photometric determination of Na(+) and K(+) and (36)Cl as a tracer for Cl(..
  87. pmc Identification of target genes for a prolactin family paralog in mouse decidua
    S M Khorshed Alam
    Department of Pathology and Laboratory MedicineInstitute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Reproduction 149:625-32. 2015
    ..g., Klk7, Rimklb, Arhgef6, Calm4, Sprr2h, Prl4a1, Ccl27, Lipg, and Htra3)...
  88. ncbi Effect of tenotomy on extensor digitorum longus muscle in Sprague Dawley rats
    N Gill
    Department of Zoology, University of the Punjab, Lahore, Pakistan
    Folia Biol (Krakow) 46:109-18. 1998
    The effect of tenotomy on Extensor Digitorum Longus (EDL) muscle, brought about by removal of anterior tibialis muscle was studied in the rat...
  89. ncbi Skeletal muscle function and water permeability in aquaporin-4 deficient mice
    B Yang
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Am J Physiol Cell Physiol 278:C1108-15. 2000
    ..Osmotic water permeability was measured in microdissected muscle fibers from the extensor digitorum longus (EDL) and fractionated membrane vesicles from EDL homogenates...
  90. ncbi Myofascial force transmission causes interaction between adjacent muscles and connective tissue: effects of blunt dissection and compartmental fasciotomy on length force characteristics of rat extensor digitorum longus muscle
    P A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Physiol Biochem 109:97-109. 2001
    Muscles within the anterior tibial compartment (extensor digitorum longus: EDL, tibialis anterior: TA, and extensor hallucis longus muscles: EHL) and within the peroneal compartment were excited simultaneously and maximally...
  91. ncbi Functional roles of the alpha isoforms of the Na,K-ATPase
    Jerry Lingrel
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Ohio 45267 0524, USA
    Ann N Y Acad Sci 986:354-9. 2003
    ..Heart and EDL muscle from animals lacking one copy of the alpha2 isoform exhibit an increase in force of contraction, while there ..
  92. ncbi Effects of modulators of sarcoplasmic Ca2+ release on the development of skeletal muscle fatigue
    E Germinario
    Department of Human Anatomy and Physiology, University of Padova, 35131 Padova, Italy
    J Appl Physiol 96:645-9. 2004
    ..the effects of Ca2+ release modulators were analyzed in vitro in mouse fast-twitch [extensor digitorum longus (EDL)] and slow-twitch (soleus) muscles, fatigued by repeated short tetani (40 Hz for 300 ms, 0...
  93. ncbi Composition and turnover of contractile proteins in volume-overtrained skeletal muscle
    T Seene
    Department of Functional Morphology, University of Tartu, Tartu, Estonia
    Int J Sports Med 25:438-45. 2004
    ..Plantaris (Pla), extensor digitorum longus (EDL), and soleus (Sol) muscles were studied...
  94. pmc Magnesium administration provokes motor unit survival, after sciatic nerve injury in neonatal rats
    N Gougoulias
    Royal Cornwall Hospital, Treslike, Truto Cornwall, TR1 3LL, United Kingdom
    BMC Musculoskelet Disord 5:33. 2004
    ..We examined the time course of the functional alterations in two types of muscles following sciatic nerve crush in neonatal rats and the neuroprotective effect of Mg2+...
  95. ncbi The role of ascorbic acid and exercise in chronic ischemia of skeletal muscle in rats
    T Loizidis
    Laboratory of Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Appl Physiol 102:321-30. 2007
    ..on muscle performance, cross-sectional area, and ultrastructural morphology in extensor digitorum longus (EDL) and soleus (Sol) muscles in rats...
  96. ncbi [Adequancy of the pharmacological disponibility in a Department of Internal Medicine to the WHO essential drug list]
    J A Díaz Peromingo
    Servicios de Medicina Interna y Farmacia, Hospital da Barbanza, Riveira, A Coruna, Spain
    An Med Interna 24:173-6. 2007
    Since several years ago, the World Health Organization (WHO), publishes the Essential Drug List (EDL) including medicines that are used to cover the mayor health community problems...
  97. doi High energy phosphate concentrations and AMPK phosphorylation in skeletal muscle from mice with inherited differences in hypoxic exercise tolerance
    Jeffrey D Overton
    Department of Biology and Marine Biology, University of North Carolina Wilmington, 601 South College Road, Wilmington, NC 28403 5915, USA
    Comp Biochem Physiol A Mol Integr Physiol 152:478-85. 2009
    ..energy phosphate (HEP) compounds was investigated in slow (soleus; SOL) and fast twitch (extensor digitorum longus; EDL) muscle from 3 strains of mice with large differences in hypoxic exercise tolerance (HET)...
  98. pmc Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
    Christian Pehmøller
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Univ of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E665-75. 2009
    ..the regulation of TBC1D1 during contraction and the potential role of AMPK in intact skeletal muscle, we used EDL muscles from wild-type (WT) and AMPK kinase dead (KD) mice...
  99. doi Hydrogenation-induced surface polarity recognition and proton memory behavior at protic-ionic-liquid/oxide electric-double-layer interfaces
    Hongtao Yuan
    Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan
    J Am Chem Soc 132:6672-8. 2010
    The electric-double-layer (EDL) formed at liquid/solid interfaces provides a broad and interdisciplinary attraction in terms of electrochemistry, photochemistry, catalysts, energy storage, and electronics...
  100. pmc Effect of Divalent Ions on Electroosmotic Flow in Microchannels
    S Datta
    201 W 19th Avenue, Mechanical Engineering, Scott Laboratory, Ohio State University, Columbus, OH 43210
    Mech Res Commun 36:65-74. 2009
    ..are identical for ions of the same valence modeled as point charges, a description of the electric double layer (EDL) based on the Poisson-Boltzmann equation alone cannot account for these experimental observations...
  101. pmc Isolation and culture of skeletal muscle myofibers as a means to analyze satellite cells
    Paul Keire
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA
    Methods Mol Biol 946:431-68. 2013
    ..The second protocol discusses the isolation of longer myofibers from the extensor digitorum longus (EDL) muscle...

Research Grants62

  1. Kiran Musunuru; Fiscal Year: 2016
    ..and secreted into the bloodstream, has been reported to inhibit lipoprotein lipase (encoded by LPL) and endothelial lipase (encoded by LIPG), increasing plasma TG and HDL-C levels in rodents...
  2. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2012
    ..all enzymes that utilize PC as substrate will be tested with respect to secretory phospholipases and endothelial lipase. The inhibitory role of SM in the generation of pro-inflammatory oxidized PCs and oxysterols will be tested ..
  3. Hong Wang; Fiscal Year: 2016
    ..severe HHcy is associated with increased HDL-C turnover and increased protein levels of hepatic/vascular endothelial lipase (EL), an HDL degradation enzyme in mice...
  4. DANIEL JAMES RADER; Fiscal Year: 2016
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  5. Endothelial lipase: a modulator of HDL metabolism and atherosclerosis in humans
    ANDREW CHARLES EDMONDSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Endothelial lipase (EL) is an extracellular protein with significant hydrolysis activity against HDL...
  6. Novel Modulators of HDL Metabolism
    Nabil A Elshourbagy; Fiscal Year: 2013
    ..Our therapeutic target is endothelial lipase (EL), a member of the lipoprotein lipase gene family that hydrolyzes HDL-C phospholipids...
  7. Endothelial Lipase: a novel therapeutic target for HDL and atherosclerosis
    XIAOMIN contact FAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is mounting evidence indicating that endothelial lipase (EL) plays a key role in the regulation of circulating cholesterol levels by modulating high-density lipoprotein-cholesterol (HDL-C) ..
  8. Temporal and Spatial patterns of structural proteins in extraocular muscles
    CAROLE MONCMAN; Fiscal Year: 2009
    ..adult EOM and compare these protein distributions to prototypic fast muscle (both adult and developing) such as the EDL. We will use biochemical and immunological tools to examine the expression patterns of the myofibrillar, ..
  9. R Graham Barr; Fiscal Year: 2014
    ..age group;consistent across components of CLRD;and comparable for genetically- estimated HDL-c based on genotype at LIPG rs61755018...
  10. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013
    ..Specifically, we will determine whether HDL genes (CETP, LPL, LIPC, ABCA1 and LIPG) interact with lifestyle intervention in predicting change in HDL at year 1 and 4 of the Look AHEAD trial, an NIH-..
  11. Neil B Ruderman; Fiscal Year: 2014
    ..Nutrient excess reduces AMPK activity and causes insulin resistance (IR) in incubated rat EDL muscle (high glucose or leucine), cultured HepG2 cells (high glucose) and muscle and liver of rats infused with ..
  12. Neuronal-specific cargo-delivery platforms as post-exposure botulism therapies
    Brenda A Wilson; Fiscal Year: 2013
    ..SNAP25 cleavage) in neuronal-specific cellular uptake in cultured neuronal cells;ex vivo in peroneal nerve-EDL muscle preparations;and in vivo after injection in mice...
  13. INSULIN AND PROTEIN SYNTHESIS AFTER RESISTANCE EXERCISE
    PETER FARRELL; Fiscal Year: 1999
    ..insulinemia on gastrocnemius (predominantly Type II), soleus (predominantly Type I), and extensor digitorum longus (EDL, predominantly Type II, but not extensively recruited during the exercise)...
  14. SKELETAL MUSCLE MICROVASCULAR PERFUSION IN HYPERTENSION
    Sarah Gray; Fiscal Year: 1999
    ..There are four AIMS to investigate various aspects of regeneration in extensor digitorum longus (EDL) and soleus (SOL) in hypertension, addressing: I) the effects of age and duration of hypertension on recovery; II) ..
  15. TORQUE GENERATION FOLLOWING SURGICAL TENDON TRANSFERS
    Richard Lieber; Fiscal Year: 1993
    ..between sarcomere length, moment arm, and torque will be determined in the mouse extensor digitorum longus (EDL) muscle following chronic length change due to immobilization and following surgical alteration of muscle moment ..
  16. E. coli O157:H7 genes induced during human infection
    INDIRA KUDVA; Fiscal Year: 2005
    ..The genes contained in reactive clones will be identified by BLAST, against the genomes of O157 EDL 933 and Sakai strains, and other DNA sequences available in the National Center for Biotechnology Information (NCBI)..
  17. SINGLE SKETETAL MUSCLE FIBER IMPAIRMENT WITH AGING
    Osvaldo Delbono; Fiscal Year: 2000
    ..with alterations in sarcoplasmic reticulum calcium release in single fast- twitch extensor digitorum longus (EDL) muscle fibers from young (8 months), middle age (18), and old (28) Fisher 344 Brown Norway F1 Hybrid rats (..
  18. Novel Modulators of HDL Metabolism
    Nabil Elshourbagy; Fiscal Year: 2009
    ..The long-term goal of this work is to develop novel drugs for increasing HDL-C. Our therapeutic target is endothelial lipase (EL), a member of the lipoprotein lipase gene family that hydrolyzes HDL phospholipids...
  19. EXERCISE, DENERVATION AND INSULIN RESISTANCE IN MUSCLE
    Paul Pilch; Fiscal Year: 2005
    ..the basis for the inhibition of insulin-stimulated glycogen synthesis in the denervated extensor digitorum longus (EDL) muscle and its restoration by incubation with AICAR...
  20. MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
    Marcia Ontell; Fiscal Year: 2004
    ..By transplanting newborn Myf 5 null extensor digitorum longus (EDL) muscles into the bed of normal hosts (where these muscle regenerate and become innervated), we can compare these ..
  21. PH REGULATION IN SKELETAL MUSCLE--DESIGN & PLASTICITY
    Robert Putnam; Fiscal Year: 1992
    ..and the properties of the transport systems responsible for recovery will be compared in mouse soleus (red) and EDL (white) muscles...
  22. CELLULAR RESPIRATION IN MUSCLE ENERGY BALANCE
    Martin Kushmerick; Fiscal Year: 2004
    ..spectroscopic and oxygen polarographic measurements of mitochondrial function will be made in excised mouse EDL (fast-twitch) and SOL (slow-twitch) muscles at rest and during contractile activity...
  23. PROPERTIES OF SKELETAL MUSCLE IN ALLOXAN DIABETES
    JIM GROSSIE; Fiscal Year: 1980
    ..Intracellular methods are to be used for recording of electrical events. The contractile properties of extensor digitorium longus (EDL) muscle will be determined in alloxan diabetic states.
  24. RYANODINE RECEPTOR REGULATION
    JOHN SUTKO; Fiscal Year: 2003
    ..Rat extensor digitorum longus (EDL) and frog semitendinosus muscles will be compared o ascertain if phosphorylation of the RyRs differ in muscles ..
  25. Causes of mitochondrial dysfunction in aging muscle
    JASON VILLARIN; Fiscal Year: 2009
    ..Isolated rat muscles that are either predominantly type-l (soleus) or type-ll (EDL) will be used to test susceptibility of particular fiber types...
  26. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2008
    ..This will be accomplished in two stages: (i) initially the weight of soleus, tibialis anterior (TA), EDL, gastrocnemius and biceps brachii (BB) muscles will be measured in congenic C57BL/6...
  27. CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN E
    Daniel Rader; Fiscal Year: 2001
    ..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
  28. Gordon Research Conference: Lipoprotein Metabolism 2004
    Daniel Rader; Fiscal Year: 2004
    ....
  29. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  30. Mentored Career Development in Patient Oriented Research
    Daniel Rader; Fiscal Year: 2006
    ..abstract_text> ..
  31. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
  32. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
  33. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  34. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006
    ..The focus of the research project is endothelial lipase (EL), a member of the triglyceride lipase family that has been shown, in mouse over expression studies, to ..
  35. Pathogenic mechanisms that initiate DMD
    Robert Grange; Fiscal Year: 2006
    ..These studies will provide valuable insight for the development of therapeutic interventions to prevent the onset of DMD. ..
  36. Role of Endothelial Lipase in Atherosclerosis
    HAMID RAZZAGHI; Fiscal Year: 2008
    ..Recently, a newly discovered gene, called endothelial lipase(EL), has been shown to have several unique features that make EL a prime candidate gene for low HDL-C and ..
  37. Pre-habilitation of Aged and Young Neuromuscular Systems
    MICHAEL DESCHENES; Fiscal Year: 2005
    ....
  38. Investigation of Human Muscle Function in vivo
    BRUCE DAMON; Fiscal Year: 2005
    ..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
  39. Identifying Kidney Disease Genes Through Mutagenesis
    RONNY KORSTANJE; Fiscal Year: 2009
    ....
  40. FUNCTIONAL STUDIES OF THE NA,K-ATPASE
    Jerry Lingrel; Fiscal Year: 2009
    ..These matings will provide animals where the alpha2 isoform is missing only in heart or smooth muscle and this will allow us to study the specific role of this isoform in cardiovascular function. ..
  41. DETERMINANTS OF EXTRAOCULAR MUSCLE FUNCTION
    Francisco H Andrade; Fiscal Year: 2010
    ..Finally, these studies will explore the deleterious consequences of aging on eye muscle function. ..
  42. Extraocular muscle aging: Functional and genomic changes
    Francisco Andrade; Fiscal Year: 2004
    ..The results from this project will establish whether life-long oxidative stress is an important deleterious influence on the EOMs, and may prove this particular muscle group is a viable model for the study of skeletal muscle aging. ..
  43. MYOCYTE RESPONSES DURING EXPERIMENTAL MYASTHENIA GRAVIS
    Keith Krolick; Fiscal Year: 2002
    ..abstract_text> ..
  44. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
  45. GENETIC DETERMINANTS OF PLASMA LIPOPROTEINS
    Jonathan Cohen; Fiscal Year: 2002
    ..These studies will help to determine the role of variation in hepatic lipase activity in determining plasma HDL concentrations, and LDL size distribution, two important risk factors for coronary artery disease. ..
  46. NA, K PUMP IN AGING SKELETAL MUSCLE
    Yuk Chow Ng; Fiscal Year: 2005
    ..The application will make use of a variety of biochemical techniques and also microdialysis to test tissue potassium fluxes. ..
  47. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  48. Role of Nitirc Oxide in Experimental Myasthenia Gravis
    Keith Krolick; Fiscal Year: 2006
    ..Specific Aim 4. Determine influences of NO production on the disease-susceptibility of the AChR-immune Lewis rat and the disease-resistance of the AChR-immune Wistar Furth rat. [unreadable] [unreadable]..
  49. Ion Channels and Chemicals Controlling Synapse Stability
    Joseph McArdle; Fiscal Year: 2006
    ..The knowledge gained from this research will enlighten future molecular approaches to treating pathologies which afflict children and adults. ..
  50. Novel hybrid AAV vectors for cystic fibrosis gene therapy
    Dongsheng Duan; Fiscal Year: 2008
    ..This is a generic approach independent of the transgene sequence. [unreadable] [unreadable] [unreadable]..
  51. Functional Dissection of Ret Signaling Pathways
    Sanjay Jain; Fiscal Year: 2008
    ..The identification of specific components of this signaling pathway will be helpful ultimately in developing targeted therapeutics for these tumors and in enhancing our understanding of nervous system development. ..
  52. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2006
    ..abstract_text> ..
  53. Age Related Insulin Resistance, Akt/PKB, and Skeletal Muscle Proteolysis
    Thomas Reynolds; Fiscal Year: 2007
    ..In accordance with the NIH-AREA initiative the goals of this R15 proposal will be accomplished by making undergraduate students an integral part of all research activities. [unreadable] [unreadable] [unreadable]..
  54. MRI Detection of Skeletal Muscle Microvascular Dysfunction
    BRUCE DAMON; Fiscal Year: 2007
    ..In these studies we will be developing new methods for studying blood flow to muscles non-invasively. [unreadable] [unreadable] [unreadable]..
  55. Skeletal Muscle Injury: Mechanism Prevention & Treatment
    Richard Lieber; Fiscal Year: 2007
    ..These studies not only provide insights into the damage mechanism, but also shed light on important structure-function relationships in normal muscle. ..
  56. The Role of Cytokeratins in Skeletal Muscle Injury
    RICHARD LOVERING; Fiscal Year: 2006
    ..The proposed research is designed to elucidate some of the shared cellular and molecular mechanisms. ..
  57. Myosin structure and strength alterations in aging females
    DAWN LOWE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Molecular Biophysics of Myosin and Actin in Aged Muscle
    DAWN LOWE; Fiscal Year: 2006
    ..abstract_text> ..
  59. The Role of Nebulin Isoforms in Thin Filament Assembly
    CAROLE MONCMAN; Fiscal Year: 2006
    ..In addition, information gained here will add to our knowledge of the roles of these proteins in normal and diseased states. [unreadable] [unreadable]..