LILRB4

Summary

Gene Symbol: LILRB4
Description: leukocyte immunoglobulin like receptor B4
Alias: CD85K, ILT-3, ILT3, LIR-5, LIR5, leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, immunoglobulin-like transcript 3, leucocyte Ig-like receptor B4, leukocyte immunoglobulin-like receptor 5, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4, monocyte inhibitory receptor HM18
Species: human

Top Publications

  1. doi Ig-like transcript 3 regulates expression of proinflammatory cytokines and migration of activated T cells
    Chih Chao Chang
    Department of Pathology, Columbia University, NewYork, NY 10032, USA
    J Immunol 182:5208-16. 2009
  2. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
  3. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
  4. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
  5. ncbi Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients
    Nicole Suciu-Foca
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Immunol 178:7432-41. 2007
  6. ncbi Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3)
    Raffaello Cortesini
    JOP 8:697-703. 2007
  7. pmc Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice
    George Vlad
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Diabetes 57:1878-86. 2008
  8. ncbi Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells
    Seunghee Kim-Schulze
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Immunol 176:2790-8. 2006
  9. doi Niflumic acid renders dendritic cells tolerogenic and up-regulates inhibitory molecules ILT3 and ILT4
    Urban Svajger
    Tissue Typing Center, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
    Int Immunopharmacol 8:997-1005. 2008
  10. doi Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
    M K Rochat
    Children s Hospital, University of Munich, Lindwurmstrasse 4, Munich, Germany
    Clin Exp Allergy 40:786-94. 2010

Research Grants

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. doi Ig-like transcript 3 regulates expression of proinflammatory cytokines and migration of activated T cells
    Chih Chao Chang
    Department of Pathology, Columbia University, NewYork, NY 10032, USA
    J Immunol 182:5208-16. 2009
    Ig-like transcript 3 (ILT3), an inhibitory receptor expressed by APC is involved in functional shaping of T cell responses toward a tolerant state...
  2. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
    ..These cytoplasmic features suggest that ILT1 and ILT2 may mediate novel transmembrane signals by which myeloid and lymphoid cell responses can be either activated or inhibited...
  3. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
    ..The cytoplasmic region of ILT3 contains putative immunoreceptor tyrosine-based inhibitory motifs that suggest an inhibitory function of ILT3...
  4. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells...
  5. ncbi Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients
    Nicole Suciu-Foca
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Immunol 178:7432-41. 2007
    ..We now describe an immune-escape mechanism mediated by the inhibitory receptor Ig-like transcript 3 (ILT3) that may be responsible for such failures...
  6. ncbi Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3)
    Raffaello Cortesini
    JOP 8:697-703. 2007
    ..We now describe an immune-escape mechanism mediated by the inhibitory receptor immunoglobulin-like transcript 3 (ILT3) which may be responsible for such failures...
  7. pmc Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice
    George Vlad
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Diabetes 57:1878-86. 2008
    ..The aim of our study was to explore the immunomodulatory activity of soluble immunoglobulin (Ig)-like transcript (ILT) 3-Fc in pancreatic islet transplantation and to determine its mechanism of action...
  8. ncbi Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells
    Seunghee Kim-Schulze
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Immunol 176:2790-8. 2006
    ..We have explored the immunomodulatory property of the extracellular region of ILT3 using a cytoplasmic deletion mutant of ILT3 (ILT3delta), expressed as membrane-bound ILT3 on KG1 cells, and a rILT3-..
  9. doi Niflumic acid renders dendritic cells tolerogenic and up-regulates inhibitory molecules ILT3 and ILT4
    Urban Svajger
    Tissue Typing Center, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
    Int Immunopharmacol 8:997-1005. 2008
    ..These results indicate the immunosuppressive properties of NFA, which may be therapeutically useful in controlling chronic immune and/or inflammatory diseases, by modulating DC characteristics towards tolerogenic DCs...
  10. doi Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
    M K Rochat
    Children s Hospital, University of Munich, Lindwurmstrasse 4, Munich, Germany
    Clin Exp Allergy 40:786-94. 2010
    ..Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown...
  11. pmc Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis
    Joseph S Zhou
    Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 204:2797-802. 2007
    ..LPS) in BALB/c mice are increased in the absence of inhibitory leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4; formerly gp49B1) in a neutrophil-dependent manner...
  12. ncbi Dendritic cells: friend or foe in autoimmunity?
    Frances Santiago-Schwarz
    Division of Rheumatology, State University of New York, Stony Brook, NY, USA
    Rheum Dis Clin North Am 30:115-34. 2004
    ..genetic engineering to introduce molecules that have immunosuppressive functions, such as IL-10, TGF3, Fas ligand, ILT3, and ILT4. Successful application to these diseases will necessitate high specificity...
  13. pmc Cytokine induced expression of programmed death ligands in human neutrophils
    Paul E Bankey
    Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Immunol Lett 129:100-7. 2010
    ..as immunoglobulin-like transcript (ILT) 4 and 5, and also comparatively low and highly variable levels of ILT2 and ILT3, but the expression of these ILTs was not significantly changed by cytokine treatment...
  14. ncbi Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: review
    Nicole Suciu-Foca
    Columbia University, Department of Pathology, 630 West 168 Street P and S 14 401, New York, NY 10032, USA
    Int Immunopharmacol 5:7-11. 2005
    ..Tolerized ILT3(high), ILT4(high) APC anergize CD4(+) T(H) cells and can induce the generation of antigen-specific CD4(+)CD25(+) T ..
  15. doi CD8+ suppressor and cytotoxic T cells recognize the same human leukocyte antigen-A2 restricted cytomegalovirus peptide
    Haiyan Qin
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 69:776-80. 2008
    ..restricted immunodominant cytomegalovirus epitope pp65-NLVPMVATV for pulsing either mature/immunogenic or ILT3(high)ILT4(high) tolerogenic dendritic cells (DC), we generated cytotoxic and suppressor CD8(+) T-cell lines, ..
  16. doi Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome
    G Kabalak
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 60:2923-5. 2009
    ..ILT2 and ILT4 play a role in tolerance induction, and ILT3 has been shown to induce Treg cells...
  17. ncbi Generation and function of antigen-specific suppressor and regulatory T cells
    Nicole Suciu-Foca
    Columbia University, Department of Pathology, 630 West 168 Street P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 11:235-44. 2003
    ..T(S) act directly on APC inducing the up-regulation of inhibitory receptors ILT3 and ILT4, which render the APC tolerogenic...
  18. ncbi IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells
    Christian A Gleissner
    Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 37:177-92. 2007
    ..of cytokine secretion, and induction of the inhibitory surface molecules immunoglobulin-like transcript 3 and 4 (ILT3/ILT4) in EC, potentially involving glucocorticoid-induced leucine zipper (GILZ)...
  19. doi DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function
    Urban Svajger
    Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
    J Leukoc Biol 89:893-905. 2011
    ..Without further DC-SIGN activation, such DCs matured with low CD80/CD86 and high ILT3 expression, along with the appearance of macrophage marker CD14...
  20. doi Induction of CD4+ CD25+ Foxp3+ T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34+ cells
    Guanqun Ge
    Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, 710061 Shaanxi, China
    Transpl Immunol 26:19-26. 2012
    Immunoglobulin-like transcript 3 (ILT3) belongs to a family of inhibitory receptors with cytoplasmic immunoreceptor tyrosine based inhibitory motifs (ITIMs)...
  21. pmc Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy
    A Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 170:212-21. 2012
    ..HAART restored normal expression levels of these receptors...
  22. doi The cellular uptake and localization of non-emissive iridium(III) complexes as cellular reaction-based luminescence probes
    Chunyan Li
    Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Biomaterials 34:1223-34. 2013
    ..mechanism via low-temperature and metabolism inhibitor assays reveal that [Ir(4-Meppy)(2)(CH(3)CN)(2)](+)OTf(-) (LIr5) with 2-phenylpyridine derivative with side-chain of methyl group at the 4-position as CˆN ligand permeates the ..
  23. pmc Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation
    Laura B Fanning
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57007. 2013
    Leukocyte Immunoglobulin-like Receptor B4 (LILRB4) null mice have an exacerbated T helper cell type 2 (Th2) immune response and pulmonary inflammation compared with Lilrb4(+/+) animals when sensitized intranasally with ovalbumin (OVA) and ..
  24. pmc Lost therapeutic potential of monocyte-derived dendritic cells through lost tissue homing: stable restoration of gut specificity with retinoic acid
    D Bernardo
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, UK
    Clin Exp Immunol 174:109-19. 2013
    ..CCR9) and a regulatory phenotype and function [decreased human leucocyte antigen D-related (HLA-DR) and increased ILT3 and fluorescein isothiocyanate (FITC-dextran uptake) in MoDC]...
  25. doi Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells
    Jelena Dokić
    Institute for Medical Research, Military Medical Academy, Belgrade, Serbia
    Eur J Immunol 43:1862-72. 2013
    ..In conclusion, PL-MSCs significantly modulate the development and functions of DCs, depending on the phase of DCs development during which the interaction occurs. ..
  26. doi Rapamycin induces ILT3(high)ILT4(high) dendritic cells promoting a new immunoregulatory pathway
    Giovanni Stallone
    Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
    Kidney Int 85:888-97. 2014
    b>ILT3(high)ILT4(high) dendritic cells (DCs) may cause anergy in CD4(+)CD45RO(+)CD25(+) T cells transforming them into regulatory T cells (Tregs)...
  27. pmc Intratracheal instillation of single-wall carbon nanotubes in the rat lung induces time-dependent changes in gene expression
    Katsuhide Fujita
    Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Nanotoxicology 9:290-301. 2015
    ..The expression levels of the genes Ctsk, Gcgr, Gpnmb, Lilrb4, Marco, Mreg, Mt3, Padi1, Slc26a4, Spp1, Tnfsf4 and Trem2 were persistently upregulated in a dose-dependent manner ..
  28. pmc Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients
    Anne Waschbisch
    Dept of Neurology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e115488. 2014
    ..To investigate this possibility, we measured expression of ILT3 and ILT4 on immune cells from multiple sclerosis patients, and in post-mortem brain tissue...
  29. doi Effect of Polarization on Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells
    Dick Papazian
    1 Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense
    Am J Respir Cell Mol Biol 53:368-77. 2015
    ..In conclusion, we determined that AEC conditioning favoring cellular integrity leads to a tolerogenic MDDC phenotype, which is likely to be important in regulating immune responses against commonly inhaled allergens. ..
  30. doi Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d
    Johannes Hofer
    Division of Clinical Experimental Immunology and Division of Immune Receptors and T Cell Activation, Institute of Immunology, Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology, and Immunology, and Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria and Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario, Canada
    FASEB J 30:1492-503. 2016
    ..Forster, F., Isenman, D. E., Wahrmann, M., Leitner, J., Hölzl, M. A., Kovarik, J. K., Stockinger, H., Böhmig, G. A., Steinberger, P., Zlabinger, G. J. Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d. ..
  31. pmc Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure
    Louise E Hogan
    Institute for Infection and Immunity, St George s, University of London, Cranmer Terrace, London, SW17 0RE
    Sci Rep 6:21780. 2016
    ..Furthermore, we demonstrate that crosslinking of this receptor on T cells increases proliferation of cytotoxic, but not helper, T cells. ..
  32. pmc TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations
    Nicholas J Colletti
    Sanofi Pharmaceuticals, Cambridge, MA, USA Department of Biological Science, Seton Hall University, South Orange, NJ, USA
    Front Immunol 7:88. 2016
    ..This Poly I:C stimulation results in four populations identifiable by flow cytometry based on their expression of ILT3 and ILT4. We focused our efforts on profiling the ILT4(-) and ILT4(+) DCs...
  33. pmc Leukocyte immunoglobulin-like receptor B4 regulates key signalling molecules involved in FcγRI-mediated clathrin-dependent endocytosis and phagocytosis
    Mijeong Park
    Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, University of NSW, Sydney, NSW 2052, Australia
    Sci Rep 6:35085. 2016
    ..We proposed the leukocyte immunoglobulin-like receptor B4 (LILRB4) that inhibits FcγRI-mediated cytokine production via Tyr dephosphorylation of multiple kinases, may also ..
  34. pmc A human dynamin-related protein controls the distribution of mitochondria
    E Smirnova
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90095 1737, USA
    J Cell Biol 143:351-8. 1998
    ..The function of this new dynamin-related protein in organelle morphology represents a novel role for a member of the dynamin family of proteins...
  35. ncbi Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity
    John S Manavalan
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int Immunol 16:1055-68. 2004
    ..Modulation of endothelial cells in favor of promoting tolerance may be important for long-term survival of organ allografts...
  36. ncbi Role of regulatory and suppressor T-cells in the induction of ILT3+ ILT4+ tolerogenic endothelial cells in organ allografts
    Nicole Suciu Foca Cortesini
    Department of Pathology, Columbia University, 630 West 168th Street P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 13:73-82. 2004
  37. ncbi Dictyopyrones, novel alpha-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum
    Akiko Arai
    Department of Basic Sciences for Medicine, Gunma University School of Health Sciences, Maebashi 371 8514, Japan
    Differentiation 73:377-84. 2005
    ..discoideum...
  38. ncbi ILT3+ ILT4+ tolerogenic endothelial cells in transplantation
    Raffaello Cortesini
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Transplantation 82:S30-2. 2006
    ..to professional APC (such as dendritic cells), endothelial cells express high levels of inhibitory receptors (ILT3 and ILT4 in humans and PIR-B in rodents) and low levels of costimulatory and adhesion molecules upon interaction ..
  39. ncbi High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells
    John S Manavalan
    Department of Pathology and Internal Medicine, Columbia University, 630 West 168th Street, P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 11:245-58. 2003
    ..cells (DC) results in the tolerization of DC by inducing the upregulation of immunologlobulin like transcript 3 (ILT3) and ILT4...
  40. doi Circulating dendritic cell number and intracellular TNF-α production in women with type 2 diabetes
    Sally E Blank
    Program in Nutrition and Exercise Physiology, Washington State University, PO Box 1495, Spokane, WA 99210 1495, USA
    Acta Diabetol 49:S25-32. 2012
    ..for plasma glucose and TNF-α concentrations, and dendritic cell subset immunophenotype (plasmacytoid, pDC, CD85k(ILT-3)(+)CD123(+)CD16(-)CD14(-) and myeloid, mDC, CD85k(ILT-3)(+)CD33(+)CD123(dim to neg)CD16(-)CD14(dim to neg))...
  41. pmc Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients
    Josh Levitsky
    Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Hepatology 57:239-48. 2013
    ..Finally, 289 novel genes and 22 proteins, several important in immunoregulatory pathways, were expressed after conversion...
  42. pmc Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients
    Mark A Jensen
    Correspondence to Professor Timothy B Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Ave, MC0930 Chicago, IL 60637, USA
    Ann Rheum Dis 72:596-601. 2013
    ..Immunoglobulin like transcript (ILT3) is an immunohibitory transmembrane molecule which is induced by type I IFNs...
  43. doi Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation
    Hanna Dobrowolska
    Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, New York, New York, USA
    Cytometry B Clin Cytom 84:21-9. 2013
    ..Immunoglobulin-like transcript 3 (ILT3) is an immune inhibitory receptor expressed by myelomonocytic cells and at high levels by tolerogenic dendritic ..
  44. doi Age-matched dendritic cell subpopulations reference values in childhood
    A Heinze
    Department of Pediatrics, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Scand J Immunol 77:213-20. 2013
    ..DC subpopulations were defined as follows: CD45(+) CD85k(+) HLA-DR(+) CD14(-) CD16(-) CD33(+) cells as myeloid DCs (mDCs) and CD45(+) CD85k(+) HLA-DR(+) CD14(-) CD16(-) ..
  45. pmc Isolation of Salmonella mutants resistant to the inhibitory effect of Salicylidene acylhydrazides on flagella-mediated motility
    Isabel Martinez-Argudo
    Schools of Cellular and Molecular Medicine and Biochemistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e52179. 2013
    ..We discuss the implications of these findings in terms of T3SS export apparatus function and drug target identification...
  46. pmc Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance
    Yi Zhang
    Department of Clinical Laboratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, PR China
    Mol Med Rep 5:910-6. 2012
    ..Immunoglobulin-like transcript (ILT)2 and ILT3 belong to the inhibitory receptors of the ILT family, which have been reported to regulate ..
  47. doi Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells
    Chih Chao Chang
    Division of Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Immunol 188:3042-52. 2012
    We have investigated the mechanism underlying the immunoregulatory function of membrane Ig-like transcript 3 (ILT3) and soluble ILT3Fc...
  48. pmc Expression of Leukocyte Inhibitory Immunoglobulin-like Transcript 3 Receptors by Ovarian Tumors in Laying Hen Model of Spontaneous Ovarian Cancer
    Mohammad Faisal Khan
    Department of Pharmacology, Rush University Medical Center, Chicago, IL, USA
    Transl Oncol 5:85-91. 2012
    ..Leukocyte immunoglobulin-like transcript 3 (ILT3) inhibitory receptors have been implicated in immunosuppression in several malignancies...
  49. doi Cyclosporine induces up-regulation of immunoglobulin-like transcripts 3 and 4 expression on and activity of NKL cells
    Y Q Si
    Department of Clinical Laboratory Medicine, Qilu Hospital of Shandong University, Jinan, China
    Transplant Proc 44:1407-11. 2012
    ..There are some studies about the effects of CsA on various human immunologic reactions, but its impact on ILT3 and ILT4 expression on natural killer (NK) cells is less well understood.
  50. ncbi Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor
    J P Arm
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 159:2342-9. 1997
    ..The data suggest that HM18 is a novel mononuclear cell inhibitory receptor homologous to mouse gp49B1...
  51. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  52. ncbi Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex
    M Torkar
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 28:3959-67. 1998
    ..Extensive sequence data were collected for ILT3, two novel genes, ILT9 and ILT10, and one novel KIR locus (KIRCI)...
  53. ncbi Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B
    L L Wang
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 162:1318-23. 1999
    ..Thus, gp49B signaling involves SHP-1, and this association is dependent on tyrosine phosphorylation of the gp49B ITIMs, and an intact SHP-1 carboxyl SH2 domain...
  54. ncbi Why so many coinhibitory receptors?
    N R Sinclair
    Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, N6 A 5C1, Canada
    Scand J Immunol 50:10-3. 1999
    ....
  55. ncbi Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    M Cella
    Basel Institute for Immunology
    Nat Med 5:919-23. 1999
    ..of lineage markers (lin-) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin-/ILT3+/ILT1+) is related to myeloid dendritic cells...
  56. pmc Plasticity in the organization and sequences of human KIR/ILT gene families
    M J Wilson
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 97:4778-83. 2000
    ..KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands...
  57. ncbi Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy
    A Heinzmann
    University Children s Hospital, University of Freiburg, Germany
    Eur J Immunogenet 27:121-7. 2000
    ..This region harbours the so-called leucocyte receptor cluster with the gene for immunoglobulin-like-transcript 3 (ILT3) as a member. ILT3 represents an inhibitory receptor bearing three immunoreceptor tyrosine inhibitory motifs (ITIM)...
  58. ncbi Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4
    W R Liu
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Immunogenetics 51:659-69. 2000
    ..4 that is immediately centromeric of the killer cell Ig-like receptor genes and are separated from one another by approximately 20 to 30 kb, suggesting that they arose by gene duplication from a common ancestor...
  59. ncbi Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex
    N T Young
    Department of Structural Biology, Stranford University School of Medicine, CA 94305, USA
    Immunogenetics 53:270-8. 2001
    ..Investigation of gene expression identified novel cDNA sequences related to the ILT2/LIR1, ILT4/LIR2, ILT3/LIR5, and ILT7 loci, while phylogenetic analysis revealed two distinct lineages of ILT/LIR genes...
  60. ncbi Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures
    R L Allen
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 167:5543-7. 2001
    ..Classical complexes bound ILT2, ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5. A free H chain form of HLA-B27 bound ILT4 and LIR6. Both forms of HLA-B27 bound KIR3DL1 transfectants...
  61. ncbi Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation
    Xin Sheng Ju
    Max Delbruck Center for Molecular Medicine, MDC, Robert Rossle Str 10, 13092, Berlin, Germany
    Gene 331:159-64. 2004
    ..ILT2 and ILT3 were expressed in PDC, Mo-DC and DC obtained from CD34(+) cells...
  62. ncbi A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro
    Florian W Velten
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Eur J Immunol 34:2800-11. 2004
    ..in DC-IL-10, eight immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing inhibitory molecules (ILT2, ILT3, ILT4, ILT5, DCIR, PILRA, FcgammaRIIB, SLAM) were found...
  63. ncbi HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DRM DSV, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    FASEB J 19:662-4. 2005
    ..We report that ILT2, ILT3, ILT4, and KIR2DL4 expression is up-regulated by HLA-G in antigen-presenting cells, NK cells, and T cells...
  64. ncbi Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells
    S Kim-Schulze
    Department of Pathology, Columbia University, New York, NY, USA
    Am J Transplant 6:76-82. 2006
    ..In previous studies, we showed that allospecific CD8+CD28- T suppressor cells (Ts) induce the expression of ILT3 in human endothelial cells (EC) rendering them tolerogenic...
  65. ncbi Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8 00168 Rome, Italy
    Blood 108:218-27. 2006
    ..Interestingly, blockade of surface immunoglobulin-like transcript 3 (ILT3) on HGFMo or neutralization of secreted IL-10 translated into partial restoration of T-cell proliferation...
  66. ncbi Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum
    Yuzuru Kubohara
    Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation IMCR, Gunma University, Maebashi 371 8512, Japan
    Dev Growth Differ 49:253-64. 2007
    ..The present results suggest that DIFs function, at least in part, via increases in [Ca(2+)](c) and [H(+)](c) in D. discoideum...
  67. ncbi [Induction of tolerogenic dendritic cells by membrane-bound HLA-G in vitro]
    Hao Zhou
    Institute of Hematology, Union Hospital, Tongji Medical College, University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:369-72. 2007
    ..Then their related immunological changes, such as membrane molecules CD80, CD86, ILT3 and ILT4 expression levels were detected by flow cytometry...
  68. ncbi Inhibition of pathologic inflammation by leukocyte Ig-like receptor B4 and related inhibitory receptors
    Howard R Katz
    Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 217:222-30. 2007
    Leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4)(previously termed gp49B1) is a member of the Ig superfamily expressed constitutively on the surface of mast cells, neutrophils, and macrophages...
  69. ncbi Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells
    Nicodemus Tedla
    Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Leukoc Biol 83:334-43. 2008
    ....
  70. pmc BDCA-1+, BDCA-2+ and BDCA-3+ dendritic cells in early human pregnancy decidua
    Y L Ban
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji Nan, Shandong, China
    Clin Exp Immunol 151:399-406. 2008
    ..This is the first study to demonstrate the presence of three previously unidentified BDCA-1+, BDCA-3+ and BDCA-2+ DC subsets in human decidua, these decidual DCs might play important role in the maintenance of pregnancy...
  71. doi Comparison of alpha-Type-1 polarizing and standard dendritic cell cytokine cocktail for maturation of therapeutic monocyte-derived dendritic cell preparations from cancer patients
    Redas Trepiakas
    Center for Cancer Immune Therapy CCIT, Department of Hematology, Herlev University Hospital, Denmark
    Vaccine 26:2824-32. 2008
    ..co-stimulatory molecules and CCR7 together with higher up-regulation of inhibitory molecules such as PD-L1, ILT2, ILT3 as compared to sDC...
  72. doi Polymorphism and linkage disequilibrium of immunoglobulin-like transcript 3 gene
    Chih Chao Chang
    Department of Pathology, Columbia University, New York, NY, USA
    Hum Immunol 69:284-90. 2008
    Immunoglobulin-like transcript 3 (ILT3) is an inhibitory receptor molecule expressed by dendritic cells, monocytes, and endothelial cells...
  73. doi Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction
    Boris Fedoric
    Transplantation Immunology Laboratory, The Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville, South Australia, Australia Department of Medicine, The University of Adelaide, South Australia, Australia
    Immunol Lett 120:49-56. 2008
    ..molecules CD40, CD80 and CD86 while the negative costimulatory molecules, immunoglobulin-like transcript 2 (ILT2), ILT3 and ILT4 have been associated with tolerogenic DC function...
  74. pmc Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X
    Natasa Obermajer
    University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Leukoc Biol 84:1306-15. 2008
    ..surface expression of costimulatory molecules, increased expression of inhibitory Ig-like transcripts 3 and 4 (ILT3 and ILT4), almost completely abolished cytokine production, diminished migration, and reduced the capacity of DCs ..
  75. ncbi Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
    Yu Mori
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, and Center of Excellence Program for Innovative Therapeutic Development Towards the Conquest of Signal Transduction Diseases, Tohoku University, Sendai, Japan
    J Immunol 181:4742-51. 2008
    ..Modulation of these regulatory receptors may be a novel way to control various skeletal system disorders and inflammatory arthritis...
  76. doi CD8+ T suppressor cells and the ILT3 master switch
    George Vlad
    Columbia University, Department of Pathology, New York, NY 10032, USA
    Hum Immunol 69:681-6. 2008
    ..This review sums up evidence that ILT3 is the centerpiece of CD8(+) Ts-driven suppression and acts as a master switch in the regulation of CD8(+) and CD4(+..
  77. doi Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient
    J H Velthuis
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 52:494-503. 2009
    ..We characterised infiltrating lymphocytes isolated from a pancreatic graft with normal endocrine function in a kidney-pancreas recipient with type 1 diabetes...
  78. doi Immunoglobulin-like transcript 3: A crucial regulator of dendritic cell function
    George Vlad
    Department of Pathology, Columbia University, New York, New York, USA
    Hum Immunol 70:340-4. 2009
    ..Conspicuously among the latter is the immunoglobulin-like transcript 3 (ILT3), which independently prevents the activation of both DC and T cells...
  79. pmc New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1)
    Lei Jiang
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 39:1167-75. 2009
    ..Ig-like receptor-1, and in addition the related inhibitory leukocyte Ig-like receptor subfamily B member 4 (CD85K, Gp49B), bound collagen specifically, whereas other cell surface proteins gave no binding...
  80. doi Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages
    Dorothee Duluc
    INSERM, U892, Angers, France
    Int J Cancer 125:367-73. 2009
    Tumor-associated macrophages (TAM) are M2d-polarized cells (IL-10(high), IL-12(low), ILT3(high), CD86(low)) that accumulate in tumor microenvironment...
  81. doi Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedside
    Peter Terness
    Institute of Immunology, University of Heidelberg, Department of Transplantation Immunology, Heidelberg, Germany
    Hum Immunol 70:506-12. 2009
    ..Although many questions remain, MMC-treated cells are a promising clinical tool for controlling allograft rejection and deleterious immune responses in autoimmune diseases...
  82. ncbi Induction of ILT expression on nonprofessional antigen presenting cells: Clinical applications
    Christian A Gleissner
    Department of Cardiology, University of Heidelberg, Medizinische Universitaetsklinik III, Heidelberg, Germany
    Hum Immunol 70:357-9. 2009
    ..Expression of ILT3 and ILT4, two members of the immunoglobulin-like transcript (ILT) family, has been demonstrated in endothelial ..
  83. doi Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc
    George Vlad
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 70:663-9. 2009
    ....
  84. doi Role of immunolglobulin-like transcript family receptors and their ligands in suppressor T-cell-induced dendritic cell tolerization
    Cecilia S C Chui
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Headington, Oxford, United Kingdom
    Hum Immunol 70:686-91. 2009
    ..DC-expressed ILT3 and ILT4 are stimulated by their cognate ligands such as major histocompatibility complex class I (MHC-I), HLA-G, ..
  85. doi Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells
    Manuela Brenk
    Department of Dermatology and Allergy, Friedrich Wilhelms University of Bonn, Germany
    J Immunol 183:145-54. 2009
    ..In contrast, the inhibitory receptors ILT3 and ILT4 are significantly increased...
  86. doi Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
    ..TNFSF4, CD28, CTLA4, ICOS, PDCD1, BTLA, CD80, CD86, HLA-G, CD274, PDCD1LG2, CD276, LILRA4, LILRB1, LILRB2, LILRB4, CD40, ICOSLG, and CD40LG...
  87. doi Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2)
    Mitsumi Hata
    The Fifth Frontier Project, Daiichi Pharmaceutical Co, Ltd, Tokyo 134 8630, Japan
    Immunol Lett 126:29-36. 2009
    ..many of them were molecules involved in Th2-skewed disease pathologies, such as FN1, ITGAE, GPNMB, PLAUR, FPRL2, LILRB4, SERPINE1, ALOX15, TBXAS1, NCF2, CCL3, IL1RN, SPARC, and STAB1, suggesting that DCs function not only as antigen ..
  88. pmc The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 4:e6846. 2009
    ..We now tested whether tumor cells can activate STAT3 within APC using the contact-dependent mechanism, in addition to soluble factors, and compared these two STAT3 activating pathways...
  89. pmc Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases
    Hao Kim Lu
    Centre for Infection and Inflammation Research, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 284:34839-48. 2009
    ..b>LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the ..
  90. pmc The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection
    Damien P Brown
    Division of Cellular and Molecular Medicine, St Georges, University of London, Centre for Infection, London, UK
    BMC Immunol 10:56. 2009
    ..High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has been observed in cancer and transplant ..
  91. pmc Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells
    Rebecca G Breslow
    Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 184:1003-13. 2010
    We previously established that the inhibitory receptor LILRB4 mitigates LPS-induced, neutrophil-dependent pathologic effector mechanisms in inflammation...
  92. pmc Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation
    Urban Svajger
    Blood Transfusion Center of Slovenia, Slajmerjeva 6, Ljubljana, Slovenia
    Immunology 129:525-35. 2010
    ..Surface expression of inhibitory immunoglobulin-like transcript 3 (ILT3) and ILT4 molecules was induced, while human leucocyte antigen (HLA)-G expression was not affected...
  93. doi Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b
    Mark A Jensen
    Department of Neurology, The University of Chicago, Chicago, IL 60637, USA
    Mult Scler 16:30-8. 2010
    ..b>ILT3 is inhibitory and is expressed preferentially by antigen-presenting cells...
  94. doi Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance
    George Vlad
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Int Rev Immunol 29:119-32. 2010
    ..phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-kappaB and MAPK p38 activity, ..
  95. doi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..CD16(+), CD11c(+), CD11b(+), HLA-DR(+), CD83(+), CD1a(-), CD1c(-), express the Ig-like transcripts (ILTs) ILT2, ILT3, ILT4, and HLA-G antigen, display high levels of CD40 and CD86, and up-regulate CD80 after differentiation in vitro...
  96. doi IFN-gamma generates maturation-arrested dendritic cells that induce T cell hyporesponsiveness independent of Foxp3+ T-regulatory cell generation
    Darling Rojas
    Transplantation Immunology Laboratory, Basil Hetzel Institute, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, South Australia
    Immunol Lett 132:31-7. 2010
    ..a downregulation in the DC maturation marker CD83 by 90% whereas the expression of the inhibitory molecules ILT2, ILT3 and ILT4 were upregulated. Inhibition of relB mRNA expression (79%; p=0.01) and IL-12 (97%; p=0...
  97. doi BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells
    Chih Chao Chang
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Immunol 185:5714-22. 2010
    Ig-like transcript 3 (ILT3) is an inhibitory receptor expressed by tolerogenic dendritic cells...
  98. doi Gene profile analysis of CD8(+) ILT3-Fc induced T suppressor cells
    George Vlad
    Department of Pathology and Cell Biology, Columbia University, New York, New York, USA
    Hum Immunol 72:107-14. 2011
    Gene profile analysis of ILT3-Fc-induced Ts revealed a significant upregulation of Zink finger proteins, most of which act as transcriptional repressors...
  99. doi Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex
    Xin Yao
    Key Laboratory of Medical Molecular Virology, Ministry of Education Ministry of Health, Shanghai Medical College, Fudan University, Shanghai, China
    J Med Virol 83:78-87. 2011
    ..The immune-related six genes up-regulated with immunogenic complex treatment were Fcgr2b, Cxcl2, Fth1, Clec4n, Lilrb4, and Dbh, with Fcgr2b (Fc gamma receptor IIB) being the highest up-regulated gene...
  100. doi Identification of a new phenotype of tolerogenic human dendritic cells induced by fungal proteases from Aspergillus oryzae
    Aline Zimmer
    Stallergènes, Antony Cedex 92183, France
    J Immunol 186:3966-76. 2011
    ..ASP-treated DCs (ASP-DCs) exhibit a CD80(-)CD83(-)CD86(-)Ig-like transcript (ILT)2(-)ILT3(-)ILT4(+) phenotype, do not secrete cytokines or chemokines, and express tolerogenic markers such as glucocorticoid-..
  101. pmc Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance
    Hao Cheng
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 286:18013-25. 2011
    The myeloid inhibitory receptor LILRB4 (also called ILT3, LIR-5, CD85k), a member of the leukocyte immunoglobulin-like receptors (LILRs/LIRs), is an important mediator of immune tolerance...

Research Grants5

  1. HLA-G - LILRB - SHP2 Axis in Airway Smooth Muscle
    Julian Solway; Fiscal Year: 2012
    ..In preliminary studies, we found that LILRB1, LILRB2, and their family member LILRB4, and SHP2 (but not SHP1) are all expressed in human ASM;that LILRB receptors activate SHP2 within human airway ..
  2. REGULATORY T CELLS IN ALLORECOGNITION
    Nicole Suciu Foca; Fiscal Year: 2004
    ..An animal model for induction of tolerance by transfer of Ts will be used. These studies will establish the role of allospecific Ts and their potential use for tolerance induction. ..
  3. Immunological Monitoring of Heart Allograft Recipients
    Nicole Suciu Foca; Fiscal Year: 2006
    ....
  4. Allograft Homing and Function of Regulatory T Cells Post-Transplant
    Wayne Hancock; Fiscal Year: 2007
    ..will build on our preliminary data indicating that Treg recruitment to an allograft leads to local upregulation of ILT3, which can then play a role in further modulate host T cell responses...
  5. Control of inflammatory diseases by gp49 receptors
    Howard Katz; Fiscal Year: 2007
    ....