LILRB2

Summary

Gene Symbol: LILRB2
Description: leukocyte immunoglobulin like receptor B2
Alias: CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10, leukocyte immunoglobulin-like receptor subfamily B member 2, CD85 antigen-like family member D, Ig-like transcript 4, leucocyte Ig-like receptor B2, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2, monocyte/macrophage immunoglobulin-like receptor 10, myeloid inhibitory receptor 10
Species: human

Top Publications

  1. doi Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
  2. pmc LILRB2 interaction with HLA class I correlates with control of HIV-1 infection
    Arman A Bashirova
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004196. 2014
  3. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
  4. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
  5. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
  6. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
  7. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
  8. ncbi The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
    N A Fanger
    Immunex Corporation, Seattle, Washington 98101, USA
    Eur J Immunol 28:3423-34. 1998
  9. pmc Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
    D S Allan
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Exp Med 189:1149-56. 1999
  10. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002

Research Grants

  1. NK CELL RECEPTOR RECOGNITION OF ORAL CANCERS
    Charles Lutz; Fiscal Year: 2004
  2. Chengcheng Zhang; Fiscal Year: 2016
  3. SOLUBLE ISOFORMS OF HLA-G: STRUCTURE, REGULATION AND FUNCTION
    JOAN SHERAR HUNT; Fiscal Year: 2011
  4. HLA-G - LILRB - SHP2 Axis in Airway Smooth Muscle
    Julian Solway; Fiscal Year: 2012
  5. Decidual macrophages in primate pregnancy
    Igor Slukvin; Fiscal Year: 2007
  6. Potential of HLA-G for transplantation
    Anatolij Horuzsko; Fiscal Year: 2007
  7. Immunological Monitoring of Heart Allograft Recipients
    Nicole Suciu Foca; Fiscal Year: 2006
  8. REGULATORY T CELLS IN ALLORECOGNITION
    Nicole Suciu Foca; Fiscal Year: 2004
  9. Functional Proteomics of HIV-1-Specific CD8+ T cells
    Xu Yu; Fiscal Year: 2007
  10. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications158 found, 100 shown here

  1. doi Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
    ..TNFSF18, TNFSF4, CD28, CTLA4, ICOS, PDCD1, BTLA, CD80, CD86, HLA-G, CD274, PDCD1LG2, CD276, LILRA4, LILRB1, LILRB2, LILRB4, CD40, ICOSLG, and CD40LG...
  2. pmc LILRB2 interaction with HLA class I correlates with control of HIV-1 infection
    Arman A Bashirova
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004196. 2014
    ..We used previously characterized HLA allotype-specific binding capacities of LILRB1 and LILRB2 as well as data from a large cohort of HIV-1-infected individuals (N = 5126) to test whether LILR-HLA class I ..
  3. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
    ..These cytoplasmic features suggest that ILT1 and ILT2 may mediate novel transmembrane signals by which myeloid and lymphoid cell responses can be either activated or inhibited...
  4. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
    ..Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake...
  5. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  6. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I ..
  7. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  8. ncbi The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
    N A Fanger
    Immunex Corporation, Seattle, Washington 98101, USA
    Eur J Immunol 28:3423-34. 1998
    ..These findings suggest that LIR-1 and LIR-2 function as unique MHC class I receptors involved in the inhibition or down-modulation of monocyte activation signals, particularly those mediated through the receptors for IgG, IgE and IgA...
  9. pmc Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
    D S Allan
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Exp Med 189:1149-56. 1999
    ..On transfectants, HLA-G tetramers bound to inhibitory immunoglobulin-like transcript (ILT)2 and ILT4 receptors...
  10. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells...
  11. pmc Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18
    Benjamin E Willcox
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    BMC Struct Biol 2:6. 2002
    Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (microM) affinities...
  12. pmc Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:8856-61. 2003
    Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) ..
  13. ncbi Transcriptional regulation of ILT family receptors
    Hideo Nakajima
    Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Immunol 171:6611-20. 2003
    ..We investigated the transcriptional regulation of ILT1, ILT2, and ILT4 genes to elucidate control mechanisms operating on the specific expression of ILT receptors...
  14. ncbi Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro
    Brigitte G Beinhauer
    BioMolecular Therapeutics, Vienna, Austria
    Eur J Immunol 34:74-80. 2004
    ..cloning approach, we show here that the inhibitory receptor LIR-2 (leukocyte immunoglobulin-like receptor-2, CD85d) is specifically up-regulated by IL-10 on maturing human DC...
  15. ncbi The LILR family: modulators of innate and adaptive immune pathways in health and disease
    D Brown
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England
    Tissue Antigens 64:215-25. 2004
    ..In this review, we summarize current knowledge on the nature and function of LILRs, focusing on their regulation of immune cell activity and their potential role in disease...
  16. ncbi Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 281:10439-47. 2006
    ..Moreover, structural and functional implications for other MHCI dimers observed in activated T cells and the pathogenic allele, HLA-B27, are discussed...
  17. pmc Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)
    Mitsunori Shiroishi
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 103:16412-7. 2006
    ..receptors leukocyte Ig-like receptor (LILR) B1 [also called LIR1, Ig-like transcript 2 (ILT2), or CD85j] and LILRB2 (LIR2/ILT4/CD85d) preferentially recognize HLA-G...
  18. pmc Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation
    Ai Masuda
    Department of Experimental Immunology, Japan Science and Technology Agency, Tohoku University, Aoba ku, Sendai shi 980 8575, Japan
    J Exp Med 204:907-20. 2007
    ..Thus, the constitutive cis binding between LILRB2 or PIR-B and MHC class I has an essential role in regulating allergic responses.
  19. doi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..CD11c(+), CD11b(+), HLA-DR(+), CD83(+), CD1a(-), CD1c(-), express the Ig-like transcripts (ILTs) ILT2, ILT3, ILT4, and HLA-G antigen, display high levels of CD40 and CD86, and up-regulate CD80 after differentiation in vitro...
  20. pmc Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
    Jinghe Huang
    Ragon Institute of MGH, Harvard, MIT, 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 84:10784-91. 2010
    ..mediated by interactions with the myelomonocytic HLA class I receptor leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4), while binding of soluble HLA-G to its alternative high-affinity receptor, LILRB1 (ILT2), appeared to be ..
  21. doi IL-10 enhances promoter activity of ILT4 gene and up-regulates its expression in THP-1 cells
    Xiaoli Xu
    Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 30:594-8. 2010
    This study examined the effect of IL-10 on immunoglobulin-like transcript (ILT4) expression of human monocytic leukemic cell line THP-1, especially the role of the ILT4 promoter activity...
  22. doi HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding
    Des C Jones
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Immunol 186:2990-7. 2011
    ..We comprehensively assessed LILR binding to >90 HLA class I alleles. The inhibitory receptors LILRB1 and LILRB2 varied in their level of binding to different HLA alleles, correlating in some cases with specific amino acid ..
  23. pmc Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming
    Jacques Banchereau
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Proc Natl Acad Sci U S A 109:18885-90. 2012
    ..In addition, blocking ILT2 or ILT4 on dermal CD14(+) DCs enhanced the generation of CTLs and inhibited TC2 cytokine production...
  24. pmc HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy
    Giada Amodio
    San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Immunol 74:406-11. 2013
    ..dendritic cells, DC-10 that secrete high amounts of IL-10 and express high levels of HLA-G and its ligand ILT4. DC-10 are present in the peripheral blood and are essential in inducing adaptive regulatory T cells...
  25. doi Upregulation of the inhibitory receptor ILT4 in monocytes from septic patients
    Eleonora Baffari
    Dept of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hum Immunol 74:1244-50. 2013
    ..Upregulation of the inhibitor receptor named immunoglobulin like transcript 4 (ILT4) is crucial to the tolerogenic function of monocytes...
  26. ncbi A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors
    N Wagtmann
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Curr Biol 7:615-8. 1997
  27. ncbi Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors
    E J Lepin
    Centre for Nephrology, Royal Free and University College Medical School, University College London, London, GB
    Eur J Immunol 30:3552-61. 2000
    ..tetramer binding could be conferred on non-binding cells by transfection with the inhibitory receptors ILT2 and ILT4. Surface plasmon resonance studies demonstrated a direct molecular interaction of HLA-F with ILT2 and ILT4...
  28. ncbi Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex
    N T Young
    Department of Structural Biology, Stranford University School of Medicine, CA 94305, USA
    Immunogenetics 53:270-8. 2001
    ..Investigation of gene expression identified novel cDNA sequences related to the ILT2/LIR1, ILT4/LIR2, ILT3/LIR5, and ILT7 loci, while phylogenetic analysis revealed two distinct lineages of ILT/LIR genes...
  29. pmc Novel HLA-G-binding leukocyte immunoglobulin-like receptor (LILR) expression patterns in human placentas and umbilical cords
    R H McIntire
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Placenta 29:631-8. 2008
    ..LILRB1 is expressed by most leukocytes and LILRB2 is expressed primarily by monocytes, macrophages and dendritic cells...
  30. ncbi Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
    Yu Mori
    Department of Experimental Immunology, Institute of Development, Aging, and Cancer, and Center of Excellence Program for Innovative Therapeutic Development Towards the Conquest of Signal Transduction Diseases, Tohoku University, Sendai, Japan
    J Immunol 181:4742-51. 2008
    ..Modulation of these regulatory receptors may be a novel way to control various skeletal system disorders and inflammatory arthritis...
  31. pmc Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction
    Demin Li
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    J Immunol 182:1033-40. 2009
    ..In this study, we report the identification of a membrane-associated protein, Ig-like transcript 4 (ILT4), as a novel human CD1d receptor that inhibits CD1d-mediated immune responses...
  32. pmc HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses
    Jinghe Huang
    The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02129 USA
    J Exp Med 206:2959-66. 2009
    ..Here, we show that the B*35-Px molecule B*3503 binds with greater affinity to immunoglobulin-like transcript 4 (ILT4), an inhibitory MHC class I receptor expressed on dendritic cells, than does the B*35-PY molecule B*3501, even ..
  33. doi Niflumic acid renders dendritic cells tolerogenic and up-regulates inhibitory molecules ILT3 and ILT4
    Urban Svajger
    Tissue Typing Center, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
    Int Immunopharmacol 8:997-1005. 2008
    ..of two inhibitory surface molecules, associated with tolerogenic DCs, immunoglobulin-like transcripts (ILT)3 and ILT4 were induced in treated DCs...
  34. doi Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
    M K Rochat
    Children s Hospital, University of Munich, Lindwurmstrasse 4, Munich, Germany
    Clin Exp Allergy 40:786-94. 2010
    ..Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown...
  35. pmc Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling
    Benoit Adam
    Centre de Biophysique Moléculaire et Numérique, Faculte Universitaire des Sciences Agronomiques de Gembloux, Gembloux, Belgium
    BMC Struct Biol 8:1. 2008
    ..This was done by analyzing the conserved interactions for ten lipocalins having a maximum pairwise identity of 28% and various functions...
  36. ncbi Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures
    R L Allen
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 167:5543-7. 2001
    ..Classical complexes bound ILT2, ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5. A free H chain form of HLA-B27 bound ILT4 and LIR6...
  37. ncbi Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies
    Lee I Garner
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, UK
    Protein Expr Purif 47:490-7. 2006
    ....
  38. pmc Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection
    Qingsheng Li
    Department of Microbiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1975-82. 2009
    ..g., CLEC12B, ILT4, galectin-3, CD160, BCMA, FGL2, LAG3, GPNMB)...
  39. pmc Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
    Nicodemus Tedla
    Division of Rheumatology, Immunology, and Allergy and Partners Asthma Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1174-9. 2003
    ..We now demonstrate the expression of LIR1 (inhibitory), LIR2 (inhibitory), LIR3 (inhibitory), and LIR7 (activating) on eosinophils from 4, 4, 12, and 11, respectively, of 12 ..
  40. ncbi Dendritic cells: friend or foe in autoimmunity?
    Frances Santiago-Schwarz
    Division of Rheumatology, State University of New York, Stony Brook, NY, USA
    Rheum Dis Clin North Am 30:115-34. 2004
    ..to introduce molecules that have immunosuppressive functions, such as IL-10, TGF3, Fas ligand, ILT3, and ILT4. Successful application to these diseases will necessitate high specificity...
  41. ncbi Immunosuppressive activity of recombinant ILT3
    George Vlad
    Department of Pathology, Columbia University, 630 West 168th Street, P and S 14 401, New York, NY 10032, USA
    Int Immunopharmacol 6:1889-94. 2006
    Tolerogenic antigen presenting cells (APC) are characterized by high expression of the inhibitory receptors ILT3 and ILT4. We have engineered ILT3 and ILT4 cytoplasmic deletion mutants (ILT3delta and ILT4delta), which were transfected in ..
  42. ncbi Mechanisms of prolongation of allograft survival by HLA-G/ILT4-modified dendritic cells
    Vladimir Ristich
    Center for Molecular Chaperone Radiobiology and Cancer Virology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Hum Immunol 68:264-71. 2007
    ..Transgenic mice expressing human ILT4 receptor exclusively on DCs and triggered by HLA-G1 developed long-term survival of allogeneic skin transplant...
  43. doi Expression of Ig-like transcript 4 inhibitory receptor in human non-small cell lung cancer
    Yuping Sun
    Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, People s Republic of China
    Chest 134:783-8. 2008
    ..Human Ig-like transcript 4 (ILT-4) is a member of the inhibitory receptor family for immune function. Little is known about the expression levels of ILT-4 in tumor cells...
  44. ncbi Paired inhibitory and triggering NK cell receptors for HLA class I molecules
    M Lopez-Botet
    Servicio de Immunologia, Hospital Universitario de la Princesa, Madrid, Spain
    Hum Immunol 61:7-17. 2000
    ..Members of a related family of immunoglobulin (Ig)-like receptors (ILT2 or LIR-1 and ILT4 or LIR-2), expressed by other leukocyte lineages, interact with a broad spectrum of class Ia molecules and HLA-G1...
  45. ncbi IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells
    Christian A Gleissner
    Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 37:177-92. 2007
    ..cytokine secretion, and induction of the inhibitory surface molecules immunoglobulin-like transcript 3 and 4 (ILT3/ILT4) in EC, potentially involving glucocorticoid-induced leucine zipper (GILZ)...
  46. ncbi Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia
    Adriana I Colovai
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Cytometry B Clin Cytom 72:354-62. 2007
    ..Inhibitory receptors from the Ig-like transcript (ILT) family, such as ILT3 and ILT4, are crucial to the tolerogenic activity of antigen presenting cells...
  47. pmc Immune modulation of HLA-G dimer in maternal-fetal interface
    Kimiko Kuroki
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Eur J Immunol 37:1727-9. 2007
    ..responses by binding to inhibitory immune cell surface receptors, such as leukocyte Ig-like receptor (LILR) B1 and LILRB2. HLA-G exists in various forms, including beta2m-associated or -free disulfide-linked dimers that can be expressed ..
  48. ncbi HLA-G molecule
    Jun Kamishikiryo
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Curr Pharm Des 15:3318-24. 2009
    ..HLA-G binds inhibitory receptors such as leukocyte immunoglobulin-like receptors B1 (LILRB1/ILT2/CD85j) and LILRB2 (ILT4/CD85d), which are widely expressed on immune cells, to suppress a broad range of immune responses...
  49. ncbi Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: review
    Nicole Suciu-Foca
    Columbia University, Department of Pathology, 630 West 168 Street P and S 14 401, New York, NY 10032, USA
    Int Immunopharmacol 5:7-11. 2005
    ..by up-regulating the cell surface expression of inhibitory receptors immunoglobulin-like transcript (ILT)-3 and ILT4 and down-regulating the expression of costimulatory molecules such as CD58 and CD86...
  50. pmc Programming of human monocytes by the uteroplacental environment
    Ramsey H McIntire
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Reprod Sci 15:437-47. 2008
    ..HLA-DR, CD86), a membrane-bound cytokine interleukin (IL)-15, leukocyte immunoglobulin-like receptors (LILRB1, LILRB2), and secreted anti-inflammatory cytokines (transforming growth factor [TGF]-beta1 and IL-10) were assessed...
  51. doi Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells
    Silvia Gregori
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Hum Immunol 70:966-9. 2009
    ..We recently described a subset of human DC, termed DC-10, that express high levels of HLA-G and ILT4, secrete high amounts of IL-10, and induce allospecific Tr1 cells in vitro via an IL-10-dependent ILT4/HLA-G ..
  52. ncbi Generation and function of antigen-specific suppressor and regulatory T cells
    Nicole Suciu-Foca
    Columbia University, Department of Pathology, 630 West 168 Street P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 11:235-44. 2003
    ..T(S) act directly on APC inducing the up-regulation of inhibitory receptors ILT3 and ILT4, which render the APC tolerogenic...
  53. ncbi Antigen presenting cells and HLA-G--a review
    R H McIntire
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Placenta 26:S104-9. 2005
    ..Macrophages and dendritic cells, which express the HLA-G receptors, ILT2 and ILT4, play major roles in driving innate and adaptive immune responses, altering the behavior of local stromal cells, ..
  54. ncbi Report of the Wet Workshop for Quantification of Soluble HLA-G in Essen, 2004
    Vera Rebmann
    Institute of Immunology, University Hospital of Essen, Essen, Germany
    Hum Immunol 66:853-63. 2005
    ..molecules exert strong inhibiting signals after interaction with their cognate receptors ILT2 (CD85j), ILT4 (CD85d), and KIR2DL4 (CD158d) that are differentially expressed by natural killer cells, T cells, and antigen-presenting ..
  55. pmc Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    FASEB J 23:806-12. 2009
    ..Five ECS-down-regulated microRNAs are known to be affected by single nucleotide polymorphisms. Thus, changes in microRNA expression are an early event following exposure to cigarette smoke...
  56. pmc Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells
    Juan Wu
    Center for Molecular Chaperone Radiobiology and Cancer Virology, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    Hum Immunol 70:353-6. 2009
    ..The double-coated microparticles increase the binding of ILT4 receptor and improve modulation of DCs in vitro and in vivo...
  57. doi Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes
    Des C Jones
    Division of Immunology, Department of Pathology, University of Cambridge, UK
    Eur J Immunol 39:3195-206. 2009
    ..Soluble LILRB1 may act as a dominant negative regulator of HLA-class I-mediated LILRB1 inhibition. Soluble isoforms of the other LILR may function in a comparable way...
  58. doi Identification of a new phenotype of tolerogenic human dendritic cells induced by fungal proteases from Aspergillus oryzae
    Aline Zimmer
    Stallergènes, Antony Cedex 92183, France
    J Immunol 186:3966-76. 2011
    ..ASP-treated DCs (ASP-DCs) exhibit a CD80(-)CD83(-)CD86(-)Ig-like transcript (ILT)2(-)ILT3(-)ILT4(+) phenotype, do not secrete cytokines or chemokines, and express tolerogenic markers such as glucocorticoid-..
  59. doi Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes
    Irit Hof-Nahor
    INSERTECH, Bruce Rappaport Department of Medicine, Technion, Haifa, Israel
    J Cell Sci 125:4640-50. 2012
    ..This mechanism of action has to be taken into account in clinical trials, where it should be beneficial in grafts and autoimmune diseases, but potentially detrimental in malignant diseases...
  60. doi The cellular uptake and localization of non-emissive iridium(III) complexes as cellular reaction-based luminescence probes
    Chunyan Li
    Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Biomaterials 34:1223-34. 2013
    ..and synthesize seven non-emissive cyclometalated iridium(III) solvent complexes [Ir(CˆN)(2)(solv)(2)](+)L(-) (LIr2-LIr8, in which CˆN = 2-phenylpyridine (ppy) or its derivative; solv = DMSO, H(2)O or CH(3)CN; L(-) = PF(6)(-) or ..
  61. doi Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients
    Juan M Fernandez-Costa
    Department of Genetics, University of Valencia, Burjasot 46100, Spain
    Hum Mol Genet 22:704-16. 2013
    ..Taken together, our results contribute to our understanding of the origin and the role of miRNA alterations in DM1...
  62. pmc Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair
    Arman A Bashirova
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
    Immunogenetics 66:1-8. 2014
    ..We suggest that the LILRA6 CNV may influence the level of the activating receptor on the cell surface, potentially affecting signaling upon LILRB3/A6 ligation. ..
  63. pmc Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors
    Maria R Lopez-Alvarez
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Immunogenetics 66:73-83. 2014
    ..In 20 out of 48 human cell lines from the International Histocompatibility Working Group, LILRA6 was deleted or duplicated. The only other LILR gene exhibiting genomic aberration was LILRA3, in this case due to a partial deletion. ..
  64. pmc Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML
    Violaine Havelange
    Division of Hematology
    Blood 123:2412-5. 2014
    ..These data support a bystander role for the miR-10 family in NPM1mut-AML...
  65. doi Glomerulonephritis-Induced Changes in Urinary and Kidney MicroRNA Profiles in Rats
    Mira Pavkovic
    Investigational Toxicology, GDD GED Toxicology, Bayer Pharma AG, 42096 Wuppertal, Germany, Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, 02115 Boston, Massachusetts, Pathology, GDD GED Toxicology, Bayer Pharma AG, 13353 Berlin, Germany and Indication Expansion, GDD GTRG Cross Indication Platform, Bayer Pharma AG, 13353 Berlin, Germany Investigational Toxicology, GDD GED Toxicology, Bayer Pharma AG, 42096 Wuppertal, Germany, Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, 02115 Boston, Massachusetts, Pathology, GDD GED Toxicology, Bayer Pharma AG, 13353 Berlin, Germany and Indication Expansion, GDD GTRG Cross Indication Platform, Bayer Pharma AG, 13353 Berlin, Germany
    Toxicol Sci 145:348-59. 2015
    ..In conclusion, our investigations support the potential of urinary miRNAs as specific BMs for kidney injury, and suggest a role of miRNAs in pathological processes during GN in the kidney...
  66. doi Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations
    Kouyuki Hirayasu
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    J Hum Genet 60:703-8. 2015
    ..LILRs have diverse functions, including the regulation of inflammation, immune tolerance, cell differentiation and nervous system plasticity. This review focuses on the genetic and functional diversity of the LILR family. ..
  67. doi MicroRNA-10 modulates Hox genes expression during Nile tilapia embryonic development
    Juliana Giusti
    Institute of Biosciences, Department of Morphology, Sao Paulo State University, Botucatu, Brazil Electronic address
    Mech Dev 140:12-8. 2016
    ..Moreover, luciferase assays demonstrated that HoxB3a and HoxD10a are targeted by miR-10b-5p. Overall, our data indicate that the miR-10 family directly regulates members of the Hox gene family during Nile tilapia embryogenesis. ..
  68. pmc LILRA6 copy number variation correlates with susceptibility to atopic dermatitis
    M R López-Álvarez
    Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Immunogenetics 68:743-7. 2016
    ..They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response. ..
  69. ncbi Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection
    Jiawang Liu
    Columbia University, Department of Pathology, 630 West 168th Street P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 13:239-47. 2004
    ..previously shown to induce the expression of the inhibitory receptors, Immunoglobulin-like transcript (ILT) 3 and ILT4 on dendritic and endothelial cells, rendering them tolerogenic to allogeneic T cells...
  70. ncbi Tolerization of dendritic cells by HLA-G
    Vladimir Ristich
    Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta 30912 2600, USA
    Eur J Immunol 35:1133-42. 2005
    ..Using human monocyte-derived DC and ILT4-transgenic mice, we show that (i) HLA-G induces the development of tolerogenic DC with arrest maturation/activation ..
  71. ncbi Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs
    O A Huynh
    Inflammatory Diseases Research Unit, Wallace Wurth Building, University of New South Wales, Sydney 2052, Australia
    Rheumatology (Oxford) 46:742-51. 2007
    ....
  72. doi Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction
    Boris Fedoric
    Transplantation Immunology Laboratory, The Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville, South Australia, Australia Department of Medicine, The University of Adelaide, South Australia, Australia
    Immunol Lett 120:49-56. 2008
    ..CD40, CD80 and CD86 while the negative costimulatory molecules, immunoglobulin-like transcript 2 (ILT2), ILT3 and ILT4 have been associated with tolerogenic DC function...
  73. doi CD8+ suppressor and cytotoxic T cells recognize the same human leukocyte antigen-A2 restricted cytomegalovirus peptide
    Haiyan Qin
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 69:776-80. 2008
    ..restricted immunodominant cytomegalovirus epitope pp65-NLVPMVATV for pulsing either mature/immunogenic or ILT3(high)ILT4(high) tolerogenic dendritic cells (DC), we generated cytotoxic and suppressor CD8(+) T-cell lines, respectively...
  74. doi Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome
    G Kabalak
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 60:2923-5. 2009
    ..ILT2 and ILT4 play a role in tolerance induction, and ILT3 has been shown to induce Treg cells...
  75. pmc Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach
    Jian Huang
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    PLoS ONE 4:e8206. 2009
    ..Genome-wide identification of miRNAs in a given organism is a critical step to facilitating our understanding of genome organization, genome biology, evolution, and posttranscriptional regulation...
  76. doi Inhibition of HLA-G expression via RNAi abolishes resistance of extravillous trophoblast cell line TEV-1 to NK lysis
    L J Chen
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Placenta 31:519-27. 2010
    ..Expression of ILT2, ILT4 and KIR2DL4 in NK cells was unchanged after 4h of co-culture, while KIR2DL4 expression increased after 48h...
  77. doi Expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium: correlations to disease activity
    N Tedla
    Inflammation and Infection Research Center, School of Medical Sciences, Department of Pathology, University of New South Wales, Sydney, NSW, Australia
    Tissue Antigens 77:305-16. 2011
    ..Here we show that activating LILRA2, A5 and inhibitory LILRB2, B3 were abundantly expressed in synovial tissue of > 75% RA patients...
  78. doi Human myeloid dendritic cells are refractory to tryptophan metabolites
    Dagmar von Bubnoff
    Department of Dermatology and Allergology, Friedrich Wilhelms University, Bonn, Germany
    Hum Immunol 72:791-7. 2011
    ..phenotype with increased expression of the inhibitory receptors immunoglobulin-like transcript 2 (ILT2), ILT3, and ILT4. In the present study, we investigated the effect of distinct tryptophan catabolites on the function of human DCs ..
  79. pmc HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I
    Joanna Giles
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Immunol 188:6184-93. 2012
    ..In this study, we characterize the interaction of HLA-B27 with LILR, leukocyte Ig-like receptor (LILR)B1 and LILRB2 immune receptors biophysically, biochemically, and by FACS staining...
  80. pmc Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors
    Kiave Yune HoWangYin
    CEA, Institute of Emerging Diseases and Innovative Therapies IMETI, Research Division in Hematology and Immunology SRHI, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75475, Paris, France
    Cell Mol Life Sci 69:4041-9. 2012
    ..and investigated whether they could bind to, and function through, the known HLA-G receptors LILRB1 and LILRB2. We report that all HLA-G isoforms may form homodimers, demonstrating for the first time the existence of HLA-G4 ..
  81. doi Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3
    George Vlad
    Columbia University, Department of Pathology and Cell Biology, 630 West 168 Street, New York, New York 10032, USA
    Exp Mol Pathol 93:294-301. 2012
    ..CD8(+) Ts induce the upregulation of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells rendering these antigen presenting cells (APCs) tolerogenic...
  82. pmc Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy
    A Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 170:212-21. 2012
    ..HAART restored normal expression levels of these receptors...
  83. pmc Identical genomic organization of two hemichordate hox clusters
    Robert Freeman
    Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA
    Curr Biol 22:2053-8. 2012
    ..We find that Saccoglossus kowalevskii and Ptychodera flava both possess 12-gene clusters, with mir10 between hox4 and hox5, in 550 kb and 452 kb intervals, respectively...
  84. doi Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum
    Guofeng Cheng
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, 518 Ziyue Road, Shanghai, 200241, China
    Parasitology 140:1751-61. 2013
    ..In summary, our findings are expected to provide useful information for further development of novel biomarkers for the diagnosis of schistosomiasis and also for deeper understanding of the mechanism of host-parasite interaction...
  85. doi Rapamycin induces ILT3(high)ILT4(high) dendritic cells promoting a new immunoregulatory pathway
    Giovanni Stallone
    Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
    Kidney Int 85:888-97. 2014
    ILT3(high)ILT4(high) dendritic cells (DCs) may cause anergy in CD4(+)CD45RO(+)CD25(+) T cells transforming them into regulatory T cells (Tregs)...
  86. pmc Downregulation of immunoglobulin-like transcript-4 (ILT4) in patients with psoriatic arthritis
    Alberto Bergamini
    Rheumatology, Allergology and Clinical Immunology, Department of Internal Medicine, Unit of Rheumatology, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 9:e92018. 2014
    The immunoglobulin-like transcript-4 (ILT4) is an inhibitory receptor that modulates the activity of innate immune agents...
  87. pmc A motif in LILRB2 critical for Angptl2 binding and activation
    Mi Deng
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX
    Blood 124:924-35. 2014
    ..Angptls) bind and activate the immune inhibitory receptor human leukocyte immunoglobulin (Ig)-like receptor B2 (LILRB2) to support ex vivo expansion of hematopoietic stem cells (HSCs) and leukemia development...
  88. pmc Paired immunoglobulin-like receptor B regulates platelet activation
    Xuemei Fan
    Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, and
    Blood 124:2421-30. 2014
    ..paired immunoglobulin-like receptors B (PIRB), as the ortholog of human leukocyte immunoglobulin-like receptor B2 (LILRB2), is involved in a variety of biological functions...
  89. pmc Role of microRNAs in schistosomes and schistosomiasis
    Lihui Zhu
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture Shanghai, China
    Front Cell Infect Microbiol 4:165. 2014
    ....
  90. doi The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer's Disease
    Min Xia
    Department of Physiology, Third Military Medical University, Chongqing, 400038, China
    Mol Neurobiol 53:455-71. 2016
    ..ARs), the Eph receptors, the paired immunoglobulin-like receptor B (PirB), the PirB's human ortholog receptor (LilrB2), and the Fcγ receptor II-b (FcγRIIb)...
  91. doi The role of soluble HLA-G and HLA-G receptors in patients with hematological malignancies after allogeneic stem cell transplantation
    Monika Biedroń
    Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, ul Pasteura 4, 50 367, Wroclaw, Poland
    Med Oncol 32:219. 2015
    ..I molecule whose suppressive activity on immune effector cells is exerted due to interactions with receptors ILT2, ILT4 and KIR2DL4...
  92. doi MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis
    Xin Wang
    Co innovation Center of Neuroregeneration, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Qixiu Road 19, Nantong 226001, China
    Cardiovasc Res 110:140-50. 2016
    ..It will be interesting to investigate new mechanism responsible for angiogenic defect induced by miR-10 knockdown...
  93. pmc Tissue engineering of cartilage in space
    L E Freed
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:13885-90. 1997
    ..g., a Mars mission, and clinical medicine, e.g., improved understanding of the effects of pseudo-weightlessness in prolonged immobilization, hydrotherapy, and intrauterine development...
  94. pmc The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium
    Nicodemus Tedla
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 160:425-31. 2002
    ..LIR-2 recognizes MHC class I molecules. We therefore suggest that LIRs may regulate the activation of infiltrating leukocytes in synovial tissue and are a potential therapeutic target...
  95. ncbi High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells
    John S Manavalan
    Department of Pathology and Internal Medicine, Columbia University, 630 West 168th Street, P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 11:245-58. 2003
    ..results in the tolerization of DC by inducing the upregulation of immunologlobulin like transcript 3 (ILT3) and ILT4. We show here that such tolerogenic DC anergize alloreactive CD4(+) CD45RO(+) CD25(+) T cells converting them into ..
  96. ncbi HLA-G modulates immune responses by diverse receptor interactions
    Valeska Hofmeister
    Department Biologie II der Ludwig Maximilians Universität München, Anthropologie und Humangenetik, Richard Wagner Str 10 I, D 80333 Munich, Germany
    Semin Cancer Biol 13:317-23. 2003
    ..can inhibit NK- and T-cell-mediated lysis of target cells by its interaction with the inhibitory receptors ILT2 and ILT4. Engaging KIR2DL4 triggers different reactions depending on the activation state of the effector cells...
  97. ncbi A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro
    Florian W Velten
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Eur J Immunol 34:2800-11. 2004
    ..DC-IL-10, eight immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing inhibitory molecules (ILT2, ILT3, ILT4, ILT5, DCIR, PILRA, FcgammaRIIB, SLAM) were found...
  98. ncbi Role of regulatory and suppressor T-cells in the induction of ILT3+ ILT4+ tolerogenic endothelial cells in organ allografts
    Nicole Suciu Foca Cortesini
    Department of Pathology, Columbia University, 630 West 168th Street P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 13:73-82. 2004
  99. pmc Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface
    Craig S Clements
    Protein Crystallography Unit, Monash Centre for Synchrotron Science, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 102:3360-5. 2005
    ..The structural data suggest a head-to-tail mode of dimerization, mediated by an intermolecular disulfide bond, that is consistent with the observation of HLA-G dimers on the cell surface...
  100. ncbi Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/ regulatory T cells
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Direction des Sciences du Vivant, Departement de Recherche Medicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    J Immunol 176:3266-76. 2006
    ..These findings provide evidence supporting the tolerogenic properties of HLA-G and emphasize its potential application as a relevant therapeutic candidate capable of limiting allograft rejection...
  101. ncbi Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide
    Simon Kollnberger
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    Eur J Immunol 37:1313-22. 2007
    ..the killer cell immunoglobulin (Ig)-like receptors KIR3DL1 and KIR3DL2 and with Ig-like transcripts LILRB1 and LILRB2. HLA-B27 tetramers complexed with three of five different naturally processed self peptides and three of seven ..

Research Grants15

  1. NK CELL RECEPTOR RECOGNITION OF ORAL CANCERS
    Charles Lutz; Fiscal Year: 2004
    ..Via knowledge of tumor ligands and NK receptor signaling, better prevention and treatment of OC-SCC may be developed. ..
  2. Chengcheng Zhang; Fiscal Year: 2016
    ..recently, we identified the immune inhibitory receptors, human leukocyte immunoglobulin (Ig)-like receptor B2 (LILRB2) and its mouse ortholog paired Ig-like receptor (PirB), as receptors for Angiopoietin-like proteins (Angptls)...
  3. SOLUBLE ISOFORMS OF HLA-G: STRUCTURE, REGULATION AND FUNCTION
    JOAN SHERAR HUNT; Fiscal Year: 2011
    ..One underlying cause may be aberrancies of synthesis or expression of G5/G6 or their LILRB1/LILRB2 receptors...
  4. HLA-G - LILRB - SHP2 Axis in Airway Smooth Muscle
    Julian Solway; Fiscal Year: 2012
    ..In preliminary studies, we found that LILRB1, LILRB2, and their family member LILRB4, and SHP2 (but not SHP1) are all expressed in human ASM;that LILRB receptors ..
  5. Decidual macrophages in primate pregnancy
    Igor Slukvin; Fiscal Year: 2007
    ..Mamu-AG can protect invading cytotrophoblasts from killing by macrophages through interaction with ILT2 and ILT4 receptors, I will address the following specific aims: 1) To characterize the distribution and immunophenotypes of ..
  6. Potential of HLA-G for transplantation
    Anatolij Horuzsko; Fiscal Year: 2007
    ..In Aim 3 we will test the hypothesis that the triggering of human inhibitory receptor ILT4 by HLA-G affects maturation/activation of dendritic cells and prolongs skin allogeneic graft survival...
  7. Immunological Monitoring of Heart Allograft Recipients
    Nicole Suciu Foca; Fiscal Year: 2006
    ....
  8. REGULATORY T CELLS IN ALLORECOGNITION
    Nicole Suciu Foca; Fiscal Year: 2004
    ..An animal model for induction of tolerance by transfer of Ts will be used. These studies will establish the role of allospecific Ts and their potential use for tolerance induction. ..
  9. Functional Proteomics of HIV-1-Specific CD8+ T cells
    Xu Yu; Fiscal Year: 2007
    ..Overall, our investigations will be relevant for defining key signaling networks of HI V-1-specific CD8+ T cells associated with protective immunity against HIV-1. [unreadable] [unreadable]..
  10. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  11. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  12. Cardiac Disease and Regeneration
    Stefanie Dimmeler; Fiscal Year: 2005
    ..As aging is a major risk factor for cardiovascular disease a special session will focus on the molecular determinants of aging and its role in cardiac diseases. ..
  13. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
    ..abstract_text> ..
  14. Hip Joint Resurfacing with Functional Human Cartilage
    Lisa Freed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. Rational Design of a Cardiac Tissue Engineering Scaffold
    Lisa E Freed; Fiscal Year: 2010
    ..abstract_text> ..