LILRA2

Summary

Gene Symbol: LILRA2
Description: leukocyte immunoglobulin like receptor A2
Alias: CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, immunoglobulin-like transcript 1, leucocyte Ig-like receptor A2, leukocyte immunoglobulin-like receptor 7, leukocyte immunoglobulin-like receptor subfamily A member 2 soluble, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
Species: human

Top Publications

  1. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
  2. pmc LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 179:8128-36. 2007
  3. ncbi Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs
    O A Huynh
    Inflammatory Diseases Research Unit, Wallace Wurth Building, University of New South Wales, Sydney 2052, Australia
    Rheumatology (Oxford) 46:742-51. 2007
  4. ncbi Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition
    David E Sloane
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 104:2832-9. 2004
  5. ncbi Use of genetic profiling in leprosy to discriminate clinical forms of the disease
    Joshua R Bleharski
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 301:1527-30. 2003
  6. pmc Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
    Nicodemus Tedla
    Division of Rheumatology, Immunology, and Allergy and Partners Asthma Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1174-9. 2003
  7. doi Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
    Kouyuki Hirayasu
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Microbiol 1:16054. 2016
  8. doi Comparison of the physiological responses and time-motion characteristics of young soccer players in small-sided games: the effect of goalkeeper
    Yusuf Köklü
    1Faculty of Sport Sciences, Pamukkale University, Denizli, Turkey 2Denizli Belediyespor Soccer Team, Denizli, Turkey and 3Department of Physical Education and Sport, Nevsehir Haci Bektas Veli University, Nevsehir, Turkey
    J Strength Cond Res 29:964-71. 2015
  9. pmc Plasticity in the organization and sequences of human KIR/ILT gene families
    M J Wilson
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 97:4778-83. 2000
  10. pmc Genetics of microscopic polyangiitis in the Japanese population
    Naoyuki Tsuchiya
    Molecular and Genetics Epidemiology Labratory, Faculty of Mecicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Ann Vasc Dis 5:289-95. 2012

Research Grants

  1. CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANS
    FRANK AUSTEN; Fiscal Year: 2007
  2. ROLE OF TOLL-LIKE RECEPTORS IN SKIN
    Robert Modlin; Fiscal Year: 2009

Scientific Experts

  • N Tedla
  • Hideo Nakajima
  • Des C Jones
  • R L Allen
  • Luiz R Goulart
  • M Colonna
  • FRANK AUSTEN
  • Robert Modlin
  • Yong Chen
  • Kouyuki Hirayasu
  • Yusuf Köklü
  • Hao K Lu
  • Naoyuki Tsuchiya
  • K Mamegano
  • Feng Gao
  • Fuliang Chu
  • George F Gao
  • Luis Borges
  • O A Huynh
  • Delphine J Lee
  • L Borges
  • Thomas H Rea
  • Maria Teresa Ochoa
  • Robert L Modlin
  • David E Sloane
  • Kyoko Shida
  • Hisashi Arase
  • Yuji Nakamaru
  • Ichiro Nakagawa
  • Tomoko Kubori
  • Joshua R Bleharski
  • Hiroji Chibana
  • Ichiro Katayama
  • Toshifumi Yamaoka
  • Keita Oikawa
  • Hiroyuki Murota
  • Noriko Arase
  • Fumiji Saito
  • Hiroki Nagai
  • Tadahiro Suenaga
  • Yunus Arslan
  • Utku Alemdaroğlu
  • Özcan Sert
  • Taline Hampartzoumian
  • Owen Huynh
  • Yasumi Endoh
  • Carolyn Geczy
  • Katherine Bryant
  • Ainslie Mitchell
  • M J Wilson
  • Lili Zong
  • Hao Peng
  • Yiwei Liu
  • Po Tien
  • K Maenaka
  • H Hashimoto
  • Y Takasaki
  • N Tsuchiya
  • S Ozaki
  • N R Sinclair
  • M Cella
  • S Kobayashi
  • R Miyashita
  • M Kusaoi
  • K Kuroki
  • K Matsuta
  • K Tokunaga
  • J P Arm
  • Stephan R Krutzik
  • T Hampartzoumian
  • M Ahern
  • M Smith
  • C L Geczy
  • J Hunt
  • Beichu Guo
  • Maristela Hernandez
  • Genhong Cheng
  • Bin Zhou
  • Peter A Sieling
  • H P McNeil
  • Donald W Macglashan
  • Muyiwa Awoniyi
  • K Frank Austen
  • S Rojo
  • J Samaridis
  • Jonathan P Arm
  • Masahiro Yamamura
  • Manfred Wagner
  • Martin Rollinghoff
  • Thomas G Graeber

Detail Information

Publications26

  1. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  2. pmc LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 179:8128-36. 2007
    ..In this study, we investigated whether leukocyte Ig-like receptor A2 (LILRA2) regulates DC differentiation by using leprosy as a model...
  3. ncbi Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs
    O A Huynh
    Inflammatory Diseases Research Unit, Wallace Wurth Building, University of New South Wales, Sydney 2052, Australia
    Rheumatology (Oxford) 46:742-51. 2007
    ....
  4. ncbi Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition
    David E Sloane
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 104:2832-9. 2004
    ..We identified LIR7, an activating member coupled to the common Fc receptor gamma chain, and LIR3, an inhibitory member containing ..
  5. ncbi Use of genetic profiling in leprosy to discriminate clinical forms of the disease
    Joshua R Bleharski
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 301:1527-30. 2003
    ..Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens...
  6. pmc Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
    Nicodemus Tedla
    Division of Rheumatology, Immunology, and Allergy and Partners Asthma Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1174-9. 2003
    ..We now demonstrate the expression of LIR1 (inhibitory), LIR2 (inhibitory), LIR3 (inhibitory), and LIR7 (activating) on eosinophils from 4, 4, 12, and 11, respectively, of 12 healthy donors...
  7. doi Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
    Kouyuki Hirayasu
    Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Microbiol 1:16054. 2016
    ..disrupted by microbial pathogens are specifically detected by leukocyte immunoglobulin-like receptor A2 (LILRA2), an orphan activating receptor expressed on human myeloid cells...
  8. doi Comparison of the physiological responses and time-motion characteristics of young soccer players in small-sided games: the effect of goalkeeper
    Yusuf Köklü
    1Faculty of Sport Sciences, Pamukkale University, Denizli, Turkey 2Denizli Belediyespor Soccer Team, Denizli, Turkey and 3Department of Physical Education and Sport, Nevsehir Haci Bektas Veli University, Nevsehir, Turkey
    J Strength Cond Res 29:964-71. 2015
    ..In addition, this study also suggests that smaller format games (i.e., 2-a-side) may promote some anaerobic adaptations for youth soccer players...
  9. pmc Plasticity in the organization and sequences of human KIR/ILT gene families
    M J Wilson
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 97:4778-83. 2000
    ..KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands...
  10. pmc Genetics of microscopic polyangiitis in the Japanese population
    Naoyuki Tsuchiya
    Molecular and Genetics Epidemiology Labratory, Faculty of Mecicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Ann Vasc Dis 5:289-95. 2012
    ..These results suggested that decreased activation of NK and/or T cells may cause a predisposition to MPA. LILRA2 is an activating receptor involved in granulocyte and macrophage activation...
  11. pmc LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes
    Hao K Lu
    Inflammation and Infection Research Centre, School of Medical Sciences, Department of Pathology, University of New South Wales, Australia corrected
    PLoS ONE 7:e33478. 2012
    The activating immunoglobulin-like receptor, subfamily A, member 2 (LILRA2) is primarily expressed on the surface of cells of the innate immunity including monocytes, macrophages, neutrophils, basophils and eosinophils but not on ..
  12. pmc The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium
    Nicodemus Tedla
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 160:425-31. 2002
    ..LIR-2 recognizes MHC class I molecules. We therefore suggest that LIRs may regulate the activation of infiltrating leukocytes in synovial tissue and are a potential therapeutic target...
  13. ncbi Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain
    H Nakajima
    Basel Institute for Immunology, Switzerland
    J Immunol 162:5-8. 1999
    ..One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction...
  14. doi Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis
    K Mamegano
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Genes Immun 9:214-23. 2008
    ..b>LILRA2 (LIR7/ILT1) is an activating receptor highly expressed in inflammatory tissues, and is involved in granulocyte and ..
  15. ncbi Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells
    S Rojo
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 158:9-12. 1997
    ..These data show that Ig-like receptors with inhibitory properties exist in both species and that mouse mast and NK cells may recognize common inhibitory ligands...
  16. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
    ..The two cDNA, called immunoglobulin-like transcripts 1 and 2 (ILT1 and ILT2), are expressed in myeloid and lymphoid cells and are homologous to bovine Fc gamma2R, human killer cell ..
  17. doi Expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium: correlations to disease activity
    N Tedla
    Inflammation and Infection Research Center, School of Medical Sciences, Department of Pathology, University of New South Wales, Sydney, NSW, Australia
    Tissue Antigens 77:305-16. 2011
    ..Here we show that activating LILRA2, A5 and inhibitory LILRB2, B3 were abundantly expressed in synovial tissue of > 75% RA patients...
  18. doi Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes
    Des C Jones
    Division of Immunology, Department of Pathology, University of Cambridge, UK
    Eur J Immunol 39:3195-206. 2009
    ..Soluble LILRB1 may act as a dominant negative regulator of HLA-class I-mediated LILRB1 inhibition. Soluble isoforms of the other LILR may function in a comparable way...
  19. ncbi Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes
    Yong Chen
    Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    J Mol Biol 386:841-53. 2009
    ..The details of binding to MHC have been described. Despite high levels of sequence similarity among LILRA1, LILRA2 (ILT1), LILRA3 (ILT6) and LILRB1/B2, all earlier experiments showed that LILRA2 does not bind to MHC, but the ..
  20. doi Leprosy pathogenetic background: a review and lessons from other mycobacterial diseases
    Luiz Ricardo Goulart
    National Reference Center of Sanitary Dermatology and Leprosy, Clinic s Hospital, School of Medicine, Federal University of Uberlândia UFU, Uberlandia, MG, Brazil
    Arch Dermatol Res 301:123-37. 2009
    ..At present, none of the genes is good prognostic marker; however, in the near future we may use multiple targets to predict infection and leprosy development...
  21. ncbi Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells
    Nicodemus Tedla
    Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Leukoc Biol 83:334-43. 2008
    ....
  22. ncbi Stability engineering, biophysical, and biological characterization of the myeloid activating receptor immunoglobulin-like transcript 1 (ILT1/LIR-7/LILRA2)
    Yong Chen
    China Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Protein Expr Purif 56:253-60. 2007
    Immunoglobulin-like transcript 1 (ILT1/LIR-7/LILRA2/CD85h) is one of the activating receptors in the ILT family whose members have been reported to regulate a broad range of cells involved in the immune response...
  23. ncbi Why so many coinhibitory receptors?
    N R Sinclair
    Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, N6 A 5C1, Canada
    Scand J Immunol 50:10-3. 1999
    ..KIR, gp49B1/gp91, PIRB1-5, LAIR-1, NKB1, Ly49 A/C/E/F/G, NKG2-A/B APC-R, CD66, CD72, PD-1, SHPS-1, SIRP-alpha1, ILT1-5, MIR7, 10, hMIR(HM18), hMIR(HM9), LIR1-3,5,8, Fas (CD95), TGFbeta-R, TNF-R1, IFNgamma-R (alpha and beta chains), ..
  24. ncbi Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    M Cella
    Basel Institute for Immunology
    Nat Med 5:919-23. 1999
    ..on the lack of lineage markers (lin-) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin-/ILT3+/ILT1+) is related to myeloid dendritic cells...
  25. ncbi Transcriptional regulation of ILT family receptors
    Hideo Nakajima
    Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Immunol 171:6611-20. 2003
    ..We investigated the transcriptional regulation of ILT1, ILT2, and ILT4 genes to elucidate control mechanisms operating on the specific expression of ILT receptors...
  26. ncbi Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures
    R L Allen
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 167:5543-7. 2001
    ..Classical complexes bound ILT2, ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5. A free H chain form of HLA-B27 bound ILT4 and LIR6...

Research Grants2

  1. CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANS
    FRANK AUSTEN; Fiscal Year: 2007
    ..The leukocyte immunoglobulin-like receptor (LIR) family is represented by an activating LIR7 and an inhibitory LIR3 on basophils, eosinophils, neutrophils, and MC progenitors (MCp)...
  2. ROLE OF TOLL-LIKE RECEPTORS IN SKIN
    Robert Modlin; Fiscal Year: 2009
    ..abstract_text> ..