LGI1

Summary

Gene Symbol: LGI1
Description: leucine rich glioma inactivated 1
Alias: ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine-rich glioma-inactivated protein 1, epitempin-1
Species: human

Top Publications

  1. ncbi A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
    O B Chernova
    Department of Neurosciences NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Oncogene 17:2873-81. 1998
  2. ncbi Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization)
    Dietmar P Rabussay
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego CA 92121, USA
    Technol Cancer Res Treat 1:71-82. 2002
  3. ncbi Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families
    Pasquale Striano
    Epilepsy Center, Department of Neurological Sciences Federico II University, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 255:16-23. 2008
  4. doi Predicting the outcome of oral food challenges with hen's egg through skin test end-point titration
    S Tripodi
    Paediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
    Clin Exp Allergy 39:1225-33. 2009
  5. pmc Localization of a gene for partial epilepsy to chromosome 10q
    R Ottman
    G H Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA
    Nat Genet 10:56-60. 1995
  6. pmc Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
    Sergey Kalachikov
    Columbia Genome Center, Columbia University, 630 W 168 Street, P and S Box 16, New York, New York 10032, USA
    Nat Genet 30:335-41. 2002
  7. ncbi Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy
    José M Morante-Redolat
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Jaume Roig 11, E 46010 Valencia, Spain
    Hum Mol Genet 11:1119-28. 2002
  8. ncbi A common protein interaction domain links two recently identified epilepsy genes
    Hartmut Scheel
    Bioinformatics Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Hum Mol Genet 11:1757-62. 2002
  9. ncbi LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures
    Wenli Gu
    Institute of Human Genetics, University Hospital Bonn, Bonn, Germany
    Ann Neurol 52:364-7. 2002
  10. ncbi Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene
    Padmaja Kunapuli
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, NY 14263, USA
    Oncogene 22:3985-91. 2003

Research Grants

  1. Josep O Dalmau; Fiscal Year: 2014
  2. Eric Lancaster; Fiscal Year: 2016
  3. Origin of Repeat Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2012
  4. Tooth pulp as a source for neuronal precursor cells to study neurogenetic disorde
    Lawrence T Reiter; Fiscal Year: 2013
  5. Ruth Ottman; Fiscal Year: 2015
  6. Repeated Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2010
  7. Expedited Partner Therapy and STI Control for MSM in Peru
    Thomas J Coates; Fiscal Year: 2012
  8. Bin He; Fiscal Year: 2014
  9. PETRA E WILDER-SMITH; Fiscal Year: 2015
  10. Efficacy of Acupuncture with PT for Knee Osteo-Arthritis
    John Farrar; Fiscal Year: 2005

Detail Information

Publications175 found, 100 shown here

  1. ncbi A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
    O B Chernova
    Department of Neurosciences NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Oncogene 17:2873-81. 1998
    ..We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene-Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced ..
  2. ncbi Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization)
    Dietmar P Rabussay
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego CA 92121, USA
    Technol Cancer Res Treat 1:71-82. 2002
    ..Within 24-48 hours, the majority of tumor cells are rapidly destroyed by this bleomycin-electroporation therapy (B-EPT). This raises the concern that healthy tissue may be similarly affected...
  3. ncbi Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families
    Pasquale Striano
    Epilepsy Center, Department of Neurological Sciences Federico II University, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 255:16-23. 2008
    ..The genetics of this condition is largely unknown.We present the electroclinical and genetic findings of 15 MTLE Italian families...
  4. doi Predicting the outcome of oral food challenges with hen's egg through skin test end-point titration
    S Tripodi
    Paediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
    Clin Exp Allergy 39:1225-33. 2009
    ..Oral food challenge (OFC) is the diagnostic 'gold standard' of food allergies but it is laborious and time consuming. Attempts to predict a positive OFC through specific IgE assays or conventional skin tests so far gave suboptimal results...
  5. pmc Localization of a gene for partial epilepsy to chromosome 10q
    R Ottman
    G H Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA
    Nat Genet 10:56-60. 1995
    ..83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval...
  6. pmc Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
    Sergey Kalachikov
    Columbia Genome Center, Columbia University, 630 W 168 Street, P and S Box 16, New York, New York 10032, USA
    Nat Genet 30:335-41. 2002
    ..we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with ..
  7. ncbi Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy
    José M Morante-Redolat
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Jaume Roig 11, E 46010 Valencia, Spain
    Hum Mol Genet 11:1119-28. 2002
    ..Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder...
  8. ncbi A common protein interaction domain links two recently identified epilepsy genes
    Hartmut Scheel
    Bioinformatics Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Hum Mol Genet 11:1757-62. 2002
    ..epilepsy, and the LGI1 gene, which is mutated in autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  9. ncbi LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures
    Wenli Gu
    Institute of Human Genetics, University Hospital Bonn, Bonn, Germany
    Ann Neurol 52:364-7. 2002
    ..lateral temporal lobe epilepsy previously has been linked to chromosome 10q22-q24, and recently mutations in the LGI1 gene (Leucine-rich gene, Glioma Inactivated) have been found in some autosomal dominant lateral temporal lobe ..
  10. ncbi Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene
    Padmaja Kunapuli
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, NY 14263, USA
    Oncogene 22:3985-91. 2003
    The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line...
  11. ncbi LGI1 mutations in temporal lobe epilepsies
    S F Berkovic
    Epilepsy Research Institute and Department of Medicine, University of Melbourne, Victoria, Australia
    Neurology 62:1115-9. 2004
    ..have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  12. pmc LGI1 mutations in autosomal dominant partial epilepsy with auditory features
    R Ottman
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 62:1120-6. 2004
    S: Mutations in LGI1 cause autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of familial temporal lobe epilepsy with auditory ictal manifestations...
  13. ncbi Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission
    Yuko Fukata
    Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Science 313:1792-5. 2006
    ..However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1...
  14. ncbi The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface
    María Salomé Sirerol-Piquer
    Unitat de Genetica Molecular, Departament de Genòmica i Proteòmica, Institut de Biomedicina de València CSIC, Spain
    Hum Mol Genet 15:3436-45. 2006
    ..b>ADLTE-related mutants of the long form are defective for secretion and are retained in the endoplasmic reticulum and ..
  15. ncbi Two novel epilepsy-linked mutations leading to a loss of function of LGI1
    Elodie Chabrol
    INSERM UMR 679, Neurologie and Thérapeutique Expérimentale, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Arch Neurol 64:217-22. 2007
    Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy.
  16. doi A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy
    Pasquale Striano
    Muscular and Neurodegenerative Diseases Unit, Institute G Gaslini, University of Genoa, Genoa, Italy
    Arch Neurol 65:939-42. 2008
    Mutations responsible for autosomal dominant lateral temporal epilepsy have been found in the leucine-rich, glioma-inactivated 1 (LGI1) gene.
  17. doi LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy
    Carlo Nobile
    Istituto di Neuroscienze del CNR, Sezione di Padova, Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Padova, Italy
    Hum Mutat 30:530-6. 2009
    Autosomal dominant lateral temporal epilepsy (ADLTE) or autosomal dominant partial epilepsy with auditory features (ADPEAF) is an inherited epileptic syndrome with onset in childhood/adolescence and benign evolution...
  18. pmc LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology
    Katherine Owuor
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 42:448-57. 2009
    ..ADAM11, nor some forms of ADAM22, contain PDZ-interacting sequences, suggesting PSD-95-independent mechanisms in ADPEAF. Because ADAMs modulate integrins, we examined LGI1 effect on neurite outgrowth...
  19. ncbi The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, D 13347 Berlin, Germany
    Trends Biochem Sci 27:441-4. 2002
    Recent studies suggest that mutations in the LGI1/Epitempin gene cause autosomal dominant lateral temporal epilepsy. This gene encodes a protein of unknown function, which we postulate is secreted...
  20. ncbi LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway
    Padmaja Kunapuli
    Roswell Park Cancer Institute, Department of Cancer Genetics, Buffalo, New York 14163, USA
    J Biol Chem 279:23151-7. 2004
    ..Progressive loss of LGI1 expression has been associated with the development of high grade gliomas...
  21. ncbi [Etiology of epilepsy in adolescents]
    J M Prats
    , Hospital de Cruces, Barakaldo, Vizcaya,
    Rev Neurol 28:32-5. 1999
    ..The latter included the Lennox-Gastaut syndrome, West syndrome, polymorphic epilepsy, etc. The etiology of these patients and related literature are reviewed in order to study the proper nosologic location of these entities...
  22. ncbi [Prognostic value of data from clinical, EEG and neuroimaging assessment in epilepsy with complex partial seizures]
    V Bertol
    , Hospital Miguel Servet, Zaragoza
    Rev Neurol 24:964-8. 1996
    ..9% and 73.7% more patient with hypersignal on long TR sequences in the group that did not decrease the frequency of their crisis to more than 50%...
  23. pmc Biofilm formation is not required for early-phase transmission of Yersinia pestis
    Sara M Vetter
    Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Microbiology 156:2216-25. 2010
    Early-phase transmission (EPT) is a recently described model of plague transmission that explains the rapid spread of disease from flea to mammal host during an epizootic...
  24. ncbi Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families
    Roberto Michelucci
    Dipartimento di Neuroscienze, Divisione di Neurologia, Ospedale Bellaria e Università di Bologna, Bologna, Italy
    Epilepsia 44:1289-97. 2003
    corrected] To describe the clinical and genetic findings of seven additional pedigrees with autosomal dominant lateral temporal epilepsy (ADLTE).
  25. ncbi Assessing mercury exposure and effects to American dippers in headwater streams near mining sites
    Charles J Henny
    USGS Forest and Rangeland Ecosystem Science Center, Corvallis, OR 97331, USA
    Ecotoxicology 14:709-25. 2005
    ..the larval/nymph form of three Orders of aquatic macroinvertebrates (Ephemeroptera, Plecoptera and Trichoptera = EPT) important in their diet from three major headwater tributaries of the upper Willamette River, Oregon in 2002...
  26. ncbi [Partial seizures during the course in patients with absence epilepsy]
    T Konishi
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
    No To Hattatsu 31:395-401. 1999
    ..Our results suggest that localized cortical areas, especially the frontal lobe, are commonly involved in absence epilepsy. More detailed clinical observation is necessary to understand the pathogenesis of absence epilepsy...
  27. ncbi Increased gallbladder trypsin in acute cholecystitis indicates functional disorder in the sphincter of oddi and could make EPT a logical procedure
    Jozef Vracko
    University Medical Center, Ljubljana, Slovenia
    Surg Laparosc Endosc Percutan Tech 13:308-13. 2003
    ..Such a study is underway to assess the possible role of obstruction at, or other disorders of, the sphincter of Oddi with consequent pancreatic juice reflux into the gallbladder as a possible initial cause of ACh...
  28. ncbi Membrane lipid biosynthesis in Chlamydomonas reinhardtii: ethanolaminephosphotransferase is capable of synthesizing both phosphatidylcholine and phosphatidylethanolamine
    Wenyu Yang
    Department of Biological Sciences, Louisiana State University, Baton Rouge 70803, USA
    Arch Biochem Biophys 430:198-209. 2004
    ..A cDNA coding for diacylglycerol: CDP-ethanolamine ethanolaminephosphotransferase (EPT) was cloned from C. reinhardtii. The C...
  29. ncbi Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin
    E Schonbrunn
    Max Planck Unit for Structural Molecular Biology, Notkestr 85, c o DESY, D 22603 Hamburg, Germany
    Structure 4:1065-75. 1996
    ..One such enzyme is UDP-N-acetylglucosamine enolpyruvyltransferase (EPT) which catalyzes the first committed step in peptidoglycan biosynthesis: the transfer of the enolpyruvyl moiety of ..
  30. ncbi Chromogranins--new sensitive markers for neuroendocrine tumors
    B Eriksson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Acta Oncol 28:325-9. 1989
    ..of chromogranin A and chromogranin A + B by hormone-producing tumors in patients with endocrine pancreatic tumors (EPT), carcinoid tumors, pheochromocytomas and small cell lung cancer (SCLC)...
  31. doi A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women
    Michael J Gast
    Wyeth Pharmaceuticals, Collegeville, PA, USA
    Menopause 16:247-56. 2009
    To evaluate the effects of combined vaginal and oral low-dose estrogen plus progestogen therapy (EPT) on the frequency and severity of dyspareunia, sexual function, and quality of life in recently postmenopausal women.
  32. ncbi Nuclear DNA distribution in neuroendocrine gastroenteropancreatic tumors before and during treatment
    B Eriksson
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Acta Oncol 28:193-7. 1989
    ..of tumor cells in 73 patients with endocrine gastrointestinal tumors, 19 patients with endocrine pancreatic tumors (EPT) and 54 patients with malignant carcinoid tumors were determined before and after treatment...
  33. doi Biaxial microincision versus coaxial small-incision cataract surgery in complicated cases
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 36:66-72. 2010
    ....
  34. pmc Papillitis and the postcholecystectomy syndrome
    E Thomas
    Division of Gastroenterology, Veterans Administration Medical Center, Johnson City, TN 37684
    J Natl Med Assoc 84:238-40. 1992
    ..of papillitis may mimic that of papillary tumor and small distal common bile duct stone; endoscopic papillotomy (EPT) with biopsy may help clarify the diagnosis. In patients with delayed drainage, EPT may be therapeutic...
  35. ncbi Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans
    Eva Kosek
    Department of Surgical Sciences, Karolinska Institute Hospital, S 171 77 Stockholm, Sweden
    Pain 105:125-31. 2003
    ..corresponding to the perception threshold to innocuous electrical stimulation, the electrical pain threshold (EPT), and pain intensity rated as 2/10, 4/10 and 6/10, respectively...
  36. doi Long-term historical analysis of benthic communities and physical habitat in an agricultural stream in California's San Joaquin River watershed
    Lenwood W Hall
    Agricultural Experiment Station, Wye Research and Education Center, University of Maryland, Queenstown, Maryland 21658, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 44:543-56. 2009
    ..The metrics % predators, % EPT index, % collectors/filterers and % shredders were the benthic metrics that were most associated with the temporal ..
  37. doi Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila
    Ryosuke Midorikawa
    Research Group of Glycobiology and Glycotechnology, Mutant Flies Laboratory, Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    J Neurosci 30:10703-19. 2010
    ..Phosphatidylserine decarboxylase (Psd) and CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (Ept)...
  38. ncbi The role of PET in localization of neuroendocrine and adrenocortical tumors
    Barbro Eriksson
    Department of Medical Sciences, Uppsala University PET Centre, University Hospital, S 751 85 Uppsala, Sweden
    Ann N Y Acad Sci 970:159-69. 2002
    ..Instead 5-HTP seems to be a universal tracer for EPT and foregut carcinoids...
  39. pmc Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones
    Wen Hsiung Chang
    Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    World J Gastroenterol 11:593-6. 2005
    ..However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance...
  40. pmc Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair
    Sandra Amado
    Centro de Estudos de Ciência Animal CECA, Instituto de Ciências e Tecnologias Agrárias e Agro Alimentares ICETA, Universidade do Porto UP, Portugal
    J Neuroeng Rehabil 7:7. 2010
    ..Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics...
  41. doi Colonization pattern of coagulase-negative staphylococci in preterm neonates and the relation to bacteremia
    M Bjorkqvist
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    Eur J Clin Microbiol Infect Dis 29:1085-93. 2010
    Coagulase-negative staphylococci (CoNS) are the major cause of sepsis in extreme preterm (EPT) newborns, but data on the CoNS colonization in EPT newborns prior to invasive infection are limited...
  42. ncbi Studies employing Saccharomyces cerevisiae cpt1 and ept1 null mutants implicate the CPT1 gene in coordinate regulation of phospholipid biosynthesis
    S C Morash
    Department of Molecular Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 269:28769-76. 1994
    ..in CPT1 derived choline-phosphotransferase activity correlated with transcript levels in both wild type and ept- backgrounds...
  43. ncbi [Characteristics and indications of topiramate]
    M Nieto-Barrera
    Servicio de Neuropediatría Hospital Infantil Universitario Virgen del Rocio, Sevilla, Espana
    Rev Neurol 35:S88-95. 2002
    ..To do so, we have made use of an analysis of the literature, together with a multi centre study conducted in Spain and personal casuistry...
  44. ncbi [Choledochus revision in the age of endoscopic papillotomy. Indications and outcome]
    H Lauschke
    Klinik und Poliklinik für Allgemein, Viszeral, Thorax und Gefasschirurgie, Universitat Bonn
    Zentralbl Chir 126:364-8. 2001
    In the age of endoscopic papillotomy (EPT) the operative revision of the bile duct needs to be used stringently and interventional therapeutic options have to be considered primarily in the treatment of gallbladder and bile duct stone ..
  45. pmc Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains
    Tracy E Strecker
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198, USA
    Genetics 169:2189-97. 2005
    ..These loci reside on chromosome 6 [Estrogen-induced pituitary tumor (Ept)1], chromosome 3 (Ept2 and Ept6), chromosome 10 (Ept9), and chromosome 1 (Ept10 and Ept13)...
  46. doi Rationale for using raloxifene to prevent both osteoporosis and breast cancer in postmenopausal women
    Wen Ling Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Chen Hsin Rehabilitation Center Taipei, Taiwan
    Maturitas 60:92-107. 2008
    ..In past decades, hormone therapy (HT), mainly estrogen plus progestin (EPT), has been frequently used for the purpose of preventing and treating postmenopausal osteoporosis because of its ..
  47. doi Inhibition of the renin-angiotensin system: effects on tachycardia-induced early electrical remodelling in rabbit atrium
    Roman Laszlo
    Department of Cardiology, University of Tubingen, Germany
    J Renin Angiotensin Aldosterone Syst 9:125-32. 2008
    ..Effects of a seven-day enalapril pre-treatment (EPT, 0...
  48. pmc Diclofenac prevents temporal increase of intraocular pressure after uneventful cataract surgery with longer operation time
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Yamato machi, Wakabayashi, Sendai, Miyagi, Japan
    Clin Ophthalmol 3:95-101. 2009
    ....
  49. ncbi Trichothecene mycotoxins from Fusarium culmorum cultures
    N C Baldwin
    Department of Pharmacy, University of Nottingham, UK
    Z Naturforsch C 42:1043-9. 1987
    ..with 3,15-diacetyldeoxynivalenol, deoxynivalenol, calonectrin, isotrichodermin and 12,13-epoxytrichothec-9-ene (EPT) as minor products...
  50. ncbi Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 13:780-6. 2006
    To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women.
  51. ncbi Separate myocardial ethanolamine phosphotransferase activities responsible for plasmenylethanolamine and phosphatidylethanolamine synthesis
    David A Ford
    Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, St Louis, MO 63104, USA
    J Lipid Res 44:554-9. 2003
    Ethanolamine phosphotransferase (EPT) is a key enzyme responsible for the synthesis of ethanolamine glycerophospholipids. Plasmenylethanolamine is a predominant molecular subclass of ethanolamine glycerophospholipids in the heart...
  52. ncbi Functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp
    Artur S P Varejao
    Department of Veterinary Sciences, CETAV, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    J Neurotrauma 21:1652-70. 2004
    ..Functional recovery was evaluated using the sciatic functional index (SFI), the extensor postural thrust (EPT) and the withdrawal reflex latency (WRL), before injury, and then at weekly intervals until week 8 postoperatively...
  53. ncbi Radiofrequency catheter ablation of Type 1 atrial flutter using a large-tip electrode catheter and high-power radiofrequency energy generator
    Gregory K Feld
    Cardiac Electrophysiology Program, University of California San Diego, 200 West Arbor Drive, 8411, San Diego, CA 92103, USA
    Expert Rev Med Devices 1:187-92. 2004
    ..b>EPT-1000 XP cardiac ablation system. There were 169 patients, aged 61 +/- 12 years involved...
  54. ncbi Medroxyprogesterone acetate inhibits the cardioprotective effect of estrogen in experimental ischemia-reperfusion injury
    Helen L Jeanes
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Menopause 13:80-6. 2006
    Results from recent clinical trials of estrogen and progestogen therapy (EPT) suggest that some progestogens may interfere with the cardiovascular benefits of estrogen (E)...
  55. pmc Activity patterns, blood lactate concentrations and ratings of perceived exertion during a professional singles tennis tournament
    Alberto Mendez-Villanueva
    Faculty of Physical Activity and Sport Sciences, Department of Didactics, University of Alcala, Madrid, Spain
    Br J Sports Med 41:296-300; discussion 300. 2007
    ..To examine the game characteristics and physiological (ie, blood lactate concentration) and perceptual (ie, rating of perceived exertion, RPE) responses during actual tennis competition in professional performers...
  56. doi A comparison of the activity profile and physiological demands between advanced and recreational veteran tennis players
    Jaime Fernandez-Fernandez
    Tennis Performance Research Group, Spanish Tennis Federation RFET, Barcelona, Spain
    J Strength Cond Res 23:604-10. 2009
    ..149.8 +/- 8.4 bpm), duration of rallies (DR) (6.3 +/- 4.1 vs. 7.6 +/- 5.5 seconds), and effective playing time (EPT) (21.7 +/- 5.0 vs. 23.6 +/- 5.4%), HR (148.3 +/- 11.5 vs. 149.8 +/- 8.4 bpm), and energy expenditure (263.1 +/- 49...
  57. ncbi Seroprevalence of human immunodeficiency virus infection among tuberculosis patients in the Nylon district hospital tuberculosis treatment centre
    G E Sume
    Delegation of Public Health, Littoral Province, P O Box 106, Douala, Cameroon
    East Afr Med J 85:529-36. 2008
    ....
  58. doi Device for cataract analysis: development and relevance to cataract surgery
    Nobuhiko Chikamoto
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    J Cataract Refract Surg 36:58-65. 2010
    ..To evaluate the relationship between World Health Organization (WHO) cataract grade determined with a new device and (1) preoperative visual acuity and (2) the difficulty of specific steps in cataract surgery...
  59. ncbi Kinetic evidence for pentachlorophenol-dependent growth of a dehalogenating population in a pentachlorophenol- and acetate-fed methanogenic culture
    S L Stuart
    Department of Civil, Construction, and Environmental Engineering, Apperson Hall 202, Oregon State University, Corvallis, Oregon 97331, USA
    Biotechnol Bioeng 57:420-9. 1998
    ..The potential at a platinum electrode, EPt, was not controlled externally, but was maintained constant at -0.25 +/- 0.002 V (vs...
  60. ncbi Assessing relationships between human land uses and the decline of native mussels, fish, and macroinvertebrates in the Clinch and Powell River watershed, USA
    Jerome M Diamond
    Tetra Tech, Owings Mills, Maryland 21117, USA
    Environ Toxicol Chem 21:1147-55. 2002
    ..Both the Ephemeroptera, Plecoptera, Trichoptera (EPT) family-level index, and the fish index of biotic integrity (IBI) were lowest in a subwatershed with the greatest ..
  61. ncbi Evaluation of variations in sensory and pain threshold assessments by electrocutaneous stimulation
    Irene Lund
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Physiother Theory Pract 21:81-92. 2005
    ..stimulation, PainMatcher (PM), was used to assess the electrical sensory thresholds (EST) and pain thresholds (EPT) in healthy volunteers and in patients with pain...
  62. ncbi Feasibility of bimanual microincision phacoemulsification in hard cataracts
    A Assaf
    Department of Ophthalmology, Ain Shams University, Nasr City, Cairo, Egypt
    Eye (Lond) 21:807-11. 2007
    ..The purpose of this work was to assess the feasibility of bimanual phacoemulsification in hard cataracts of N3+ using WhiteStar technology of Soveriegn (Advanced Medical Optics, Santa Ana, CA, USA)...
  63. ncbi Identification and characterization of human ethanolaminephosphotransferase1
    Yasuhiro Horibata
    Neuronal Circuit Mechanisms Research Group, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    J Lipid Res 48:503-8. 2007
    CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE)...
  64. doi Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features
    Olivier Corcos
    Pôle des Maladies de l Appareil Digestif, AP HP, Hopital Beaujon, Clichy, Paris, France
    Pancreas 37:85-93. 2008
    ..We aimed to assess (1) the accuracy of somatostatin receptor scintigraphy, (2) histological features with focus on malignancy and genotype-phenotype correlations, and (3) prognosis of VHL-EPT.
  65. doi Development of the HLA proficiency testing for Central and East Europe
    K Bogunia-Kubik
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Int J Immunogenet 35:409-16. 2008
    In order to increase the reliability of histocompatibility testing, several external proficiency testing (EPT) schemes have been established within Europe...
  66. ncbi The sn-1,2-diacylglycerol ethanolaminephosphotransferase activity of Saccharomyces cerevisiae. Isolation of mutants and cloning of the EPT1 gene
    R H Hjelmstad
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 263:19748-57. 1988
    ..to identify nine Saccharomyces cerevisiae mutants defective in in situ ethanolaminephosphotransferase activity (ept mutants). Genetic analysis revealed five complementation groups...
  67. ncbi A BAC library for the goldfish Carassius auratus auratus (Cyprinidae, Cypriniformes)
    Jing Luo
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
    J Exp Zool B Mol Dev Evol 306:567-74. 2006
    ..Preliminary screens with two genes were conducted with hybridizing probes to the genes RAG1 and lgi1. RAG1 is a single-copy gene in zebrafish and is duplicated in C. a. auratus...
  68. ncbi Estrogen-progestin therapy in women after stem cell transplant: our experience and literature review
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Menopause 14:320-30. 2007
    ..Because of the likelihood of the need for long-lasting estrogen plus progestin therapy (EPT) and the increased risk of secondary neoplasia after SCT, the EPT should be as physiological as possible...
  69. ncbi Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis
    Takeshi Tokai
    Plant and Microbial Metabolic Engineering Research Unit, Discovery Research Institute DRI, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 353:412-7. 2007
    ..2), and a small amount of non-Fusarium trichothecene 12,13-epoxytrichothec-9-ene (EPT)...
  70. pmc Evolution of an international external quality assurance model to support laboratory investigation of Streptococcus pneumoniae, developed for the SIREVA project in Latin America, from 1993 to 2005
    Marguerite Lovgren
    National Centre for Streptococcus, Rm 1B3 26 WMC, Provincial Public Health Laboratory, 8440 112 St, Edmonton, T6G 2J2 Alberta, Canada
    J Clin Microbiol 45:3184-90. 2007
    ..by the National Centre for Streptococcus (NCS), Edmonton, Canada, and included external proficiency testing (EPT) and a validation process requiring regular submission of a sample of isolates from each laboratory to the NCS for ..
  71. pmc Risk factors for recurrent bile duct stones after endoscopic papillotomy
    T Ando
    First Department of Medicine, Chiba University School of Medicine, Chiba, Japan
    Gut 52:116-21. 2003
    The long term outcome of endoscopic papillotomy (EPT) is not well known. The aims of this study were to clarify the clinical course of post-EPT patients and to detect predictors for bile duct stone recurrence.
  72. ncbi Postmenopausal estrogen and progestogen therapy and the risk of uterine leiomyomas
    Susan D Reed
    Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle, Washington 98104, USA
    Menopause 11:214-22. 2004
    ..We examined the risk of a first diagnosis of leiomyomas in peri- and postmenopausal women associated with prior use of estrogen and progestogen therapy (EPT).
  73. ncbi A quantitative tool for assessing the integrity of southern coastal California streams
    Peter R Ode
    Aquatic Bioassessment Laboratory, Water Pollution Control Laboratory, Department of Fish and Game, 2005 Nimbus Road, Rancho Cordova, California 95670, USA
    Environ Manage 35:493-504. 2005
    ..non-insect taxa, percent tolerant taxa, Coleoptera richness, predator richness, percent intolerant individuals, and EPT richness...
  74. ncbi Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle
    Cheryl A Collier
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 291:E182-9. 2006
    ..acute effects of metformin on fatty acid (FA) metabolism in oxidative soleus (SOL) and glycolytic epitrochlearis (EPT) rodent muscle...
  75. ncbi Clitoral circulation in postmenopausal women with sexual dysfunction: a pilot randomized study with hormone therapy
    Rossella E Nappi
    Research Center for Reproductive Medicine, University of Pavia, Italy
    Maturitas 55:288-95. 2006
    ..Vaginal health and sexual function were also investigated...
  76. pmc Average household exposure to newspaper coverage about the harmful effects of hormone therapy and population-based declines in hormone therapy use
    Jennifer S Haas
    Division of General Medicine and Primary Care, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120 1613, USA
    J Gen Intern Med 22:68-73. 2007
    The news media facilitated the rapid dissemination of the findings from the estrogen plus progestin therapy arm of the Women's Health Initiative (EPT-WHI).
  77. ncbi Training or EPT in perimenopause on balance and flushes
    Ingrid Bergström
    Center for Endocrinology, Metabolism and Diabetes, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:467-72. 2007
    ..balance function during the perimenopausal period, and evaluate the effect of estrogen plus progesterone therapy (EPT) or aerobic training on balance. Sixty perimenopausal women were recruited to the study...
  78. ncbi Changes in the serum levels of osteoprotegerin and soluble receptor activator for nuclear factor kappaB ligand after estrogen-progestogen therapy and their relationships with changes in bone mass in postmenopausal women
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    Menopause 15:357-62. 2008
    ..and soluble receptor activator for nuclear factor kappaB ligand (sRANKL) after estrogen plus progestogen therapy (EPT) and to determine their relationships with changes in bone mineral density (BMD) and bone turnover markers in ..
  79. doi Multi-frequency bioelectrical impedance analysis of skin rubor with two-electrode technique
    Tomoka Uchiyama
    Department of Human Environmental Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Otsuka Bunkyou ku, Tokyo 112 8610, Japan
    J Tissue Viability 17:110-4. 2008
    ..Skin rubor, or reddish discoloration on skin, is a sign of irritation. Physiologically it involves temporary vasodilation and hyperaemia in tissue, and is diagnosed by the visible characteristics...
  80. ncbi Estrogens, progestins, and risk of breast cancer
    M C Pike
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Ernst Schering Found Symp Proc . 2007
    ..This suggests that the effects of menopausal estrogen therapy (ET) and menopausal estrogen-progestin therapy (EPT) on a woman's breast cancer risk will greatly depend on her body mass index (BMI; weight in kilograms/height in ..
  81. pmc Somatic alterations in brain tumors
    Jill Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Oncol Rep 20:203-10. 2008
    ..Emerging evidence shows that mutations are involved in LGI1 in brain tumor progression...
  82. doi Reliability of cutaneous electrical perceptual threshold in the assessment of sensory perception in patients with spinal cord injury
    Nicolas K K King
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, London, United Kingdom
    J Neurotrauma 26:1061-8. 2009
    The electrical perceptual threshold (EPT) test complements the American Spinal Injury Association (ASIA) assessment of cutaneous sensory function by providing a quantitative assessment for each dermatome...
  83. doi Relationship between circulating tumor necrosis factor system and bone mass before and after estrogen plus progestogen therapy
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    Menopause 16:534-8. 2009
    The aim of his study was to investigate the relationship between the circulating tumor necrosis factor (TNF) system and bone mineral density (BMD) before and after estrogen plus progestogen therapy (EPT).
  84. ncbi [Assessing bioaccumulation and bioavailability of PAHs and OCPs in water using sediment, rare minnow and biomimetic sampler]
    Jian Ping Luo
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Huan Jing Ke Xue 30:610-5. 2009
    ..rare minnow were lower about one order of magnitude than those (1-4) predicted by equilibrium partitioning theory (EPT). However, TSAFs of PAHs and OCPs for TECAM were almost consistent with the EPT...
  85. ncbi [Engineering and metabolic characteristics of a Clostridium tyrobutyricum strain]
    Guiqing Yang
    Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen, China
    Sheng Wu Gong Cheng Xue Bao 26:170-6. 2010
    ..tyrobutyricum. We fused these genes with pUC19 to construct nonreplicative integrated plasmids pUC19-EPT. Then we transformed pUC19-EPT into C. tyrobutyricum through electroporation...
  86. doi Expedited partner therapy: a robust intervention
    Frances Shiely
    Department of Epidemiology and Public Health, University College Cork, Ireland
    Sex Transm Dis 37:602-7. 2010
    Expedited partner therapy (EPT) has been shown to reduce the risk of persistent or recurrent gonorrhea and chlamydial infection in heterosexuals, and to increase the proportion of sex partners receiving treatment...
  87. doi Endometrial cancer associated with various forms of postmenopausal hormone therapy: a case control study
    Susanna Jaakkola
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 128:1644-51. 2011
    This study evaluates the effect of different modes of estradiol-progestagen therapy (EPT) regimens on the postmenopausal endometrial cancer risk in Finland...
  88. doi Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011
    To describe a distinctive seizure semiology that closely associates with voltage-gated potassium channel (VGKC)-complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE).
  89. doi Morvan's syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex
    Panayiotis Loukaides
    Limassol General Hospital, Limassol, Cyprus
    J Neurol Sci 312:52-6. 2012
    ..antigenic targets using immunohistochemistry and cell-based assays revealed that he had autoantibodies targeting Lgi1, Caspr2 and Contactin-2/Tag-1, all proteins known to be complexed with VGKC in peripheral nerves and CNS...
  90. pmc LGI1 microdeletion in autosomal dominant lateral temporal epilepsy
    M Fanciulli
    Porto Conte Ricerche, Alghero, Italy
    Neurology 78:1299-303. 2012
    To characterize clinically and genetically a family with autosomal dominant lateral temporal epilepsy (ADLTE) negative to LGI1 exon sequencing test.
  91. pmc ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy
    Laura Rigon
    CNR Institute of Neurosciences, Section of Padua, Department of Experimental Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padova, Italy
    Epilepsy Res Treat 2011:258365. 2011
    ..Mutations responsible for ADLTE have been found in the LGI1 gene...
  92. pmc Pharmacokinetics of peptide mediated delivery of anticancer drug ellipticine
    Weina Ma
    Department of Pharmacy, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 7:e43684. 2012
    ..pairing peptide EAK16-II (EAK) has shown the ability to stabilize the hydrophobic anticancer agent ellipticine (EPT) in aqueous solution...
  93. doi Photoinduced proton-coupled electron transfer of hydrogen-bonded p-nitrophenylphenol-methylamine complex in solution
    Chaehyuk Ko
    Department of Chemistry, 600 South Mathews Avenue, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    J Phys Chem B 117:316-25. 2013
    Proton-coupled electron transfer can occur through concerted (electron-proton transfer, EPT) or sequential mechanisms, but this distinction becomes less well-defined for photoinduced reactions...
  94. doi fMRI: blood oxygen level-dependent activation during a working memory-selective attention task in children born extremely preterm
    Silja Torvik Griffiths
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Pediatr Res 74:196-205. 2013
    Extremely preterm (EPT)/extremely low-birth-weight (ELBW) children attaining school age and adolescence often have problems with executive functions such as working memory and selective attention...
  95. doi Development of a benthic multimetric index for the Serra da Bocaina bioregion in Southeast Brazil
    D F Baptista
    Laboratório de Avaliação e Promoção da Saúde Ambiental LAPSA, IOC FIOCRUZ, CEP 21045 900ManguinhosRJ, Brazil
    Braz J Biol 73:573-83. 2013
    ..valid to integrate the MISB: Family Richness, Trichoptera Richness, % Coleoptera, % Diptera, IBE-IOC index, EPT / Chironomidae ratio...
  96. doi Computational tests of quantum chemical models for excited and ionized states of molecules with phosphorus and sulfur atoms
    David K Hahn
    Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849 5312, United States
    J Phys Chem A 118:3514-24. 2014
    Time-dependent density functional theory (TD-DFT) and electron propagator theory (EPT) are used to calculate the electronic transition energies and ionization energies, respectively, of species containing phosphorus or sulfur...
  97. doi Visually determined stream mesohabitats influence benthic macroinvertebrate assessments in headwater streams
    Déborah R O Silva
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, CP 486, CEP 30161 970, Belo Horizonte, Minas Gerais, Brazil
    Environ Monit Assess 186:5479-88. 2014
    ..abundance and presence-absence of all macroinvertebrate families and of Ephemeroptera, Plecoptera, and Trichoptera (EPT) genera. We systematically sampled a wide variety of mesohabitat arrangements as they occured in stream sites...
  98. pmc Cell-surface central nervous system autoantibodies: clinical relevance and emerging paradigms
    Sarosh R Irani
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom Multiple Sclerosis and Neuroinflammation Center, Department of Neurology, University of California, San Francisco, San Francisco, CA
    Ann Neurol 76:168-84. 2014
    ..are directed against the extracellular domains of cell-surface-expressed neuronal or glial proteins such as LGI1, N-methyl-D-aspartate receptor, and aquaporin-4...
  99. doi Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes
    Ning Chen
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands
    Biochim Biophys Acta 1854:827-33. 2015
    ..which lacks most of the extracellular domains, however, is still associated with ADAM22 and to a lesser extent LGI1 and Kv1 channels...
  100. doi Use of cell-based assays in myasthenia gravis and other antibody-mediated diseases
    P M Rodriguez Cruz
    Nuffield Department of Clinical Neurosciences and Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Exp Neurol 270:66-71. 2015
    ..have been used in the routine detection of antibodies to proteins expressed on the surface of neurons (NMDAR, LGI1, CASPR2, AMPAR, GABA-A/B, GlyR, and DPPX) and glia (AQP4, MOG)...

Research Grants59

  1. Josep O Dalmau; Fiscal Year: 2014
    ..subunits of the AMPA receptor (AMPAR), the GABA(B1) receptor (GABA(B1)R), Leucine rich glioma inactivated 1 (LGI1) and Contactin associated protein 2 (Caspr2)...
  2. Eric Lancaster; Fiscal Year: 2016
    ..antibodies previously attributed to potassium channels actually target two potassium channel associated proteins, LGI1 and CASPR2 (Lai et al., 2010;Lancaster et al., 2011)...
  3. Origin of Repeat Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2012
    ..Aim 2: To conduct in-depth exploration of the origins of repeat Ct and/or Mg infections and explore adaptations of EPT and/or rescreening among heterosexual men...
  4. Tooth pulp as a source for neuronal precursor cells to study neurogenetic disorde
    Lawrence T Reiter; Fiscal Year: 2013
    ..Here we propose to use dental pulps from exfoliated primary teeth (EPT), as a source of stem cells for the study of a variety of neurogenetic syndromes...
  5. Ruth Ottman; Fiscal Year: 2015
    ..lobe epilepsy initially described by our group, "autosomal dominant partial epilepsy with auditory features" (ADPEAF). Half of these families were previously found to have mutations in the LGI1 gene on chromosome 10...
  6. Repeated Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2010
    ..For women, expedited partner treatment (EPT) and rescreening at 3 months has been recommended, but only EPT has been recommended for men citing lack of ..
  7. Expedited Partner Therapy and STI Control for MSM in Peru
    Thomas J Coates; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, but has not been evaluated for use among men who ..
  8. Bin He; Fiscal Year: 2014
    ..R21 exploratory project is to explore and develop a novel magnetic resonance electrical property tomography (MR-EPT) technique for the quantitative prediction and proactive management of tissue heating in high-field MRI ..
  9. PETRA E WILDER-SMITH; Fiscal Year: 2015
    ..negative predictive value of pulpal vitality that excees the values found with either an Electrical Pulp Tester (EPT) or thermal tests...
  10. Efficacy of Acupuncture with PT for Knee Osteo-Arthritis
    John Farrar; Fiscal Year: 2005
    ..trial evidence of efficacy for the standard treatments of acetaminophen and NSAIDs, and exercise physical therapy (EPT), which is usually added when the patient develops functional limitations...
  11. ENZYME INTERMEDIATE STRUCTURES BY NMR
    Michael Smerdon; Fiscal Year: 2002
    ..The project will be extended to include uridine diphosphate N-acetyl-glucosamine enolpyruvyl transferase (UDP-NAG EPT) and 3-deoxy-D-manno-2-octulosonate-8-phosphate (KD08P) synthase...
  12. Choline phosphotransferase-dependent phospholipid synthesis in Treponema
    J Fenno; Fiscal Year: 2009
    ..In many eukaryotes, this enzyme also has 1,2-diacylglycerol ethanolamine phosphotransferase (EPT) activity required for phosphatidylethanolamine (PtdEtn) synthesis. In T...
  13. Signaling and Crosstalk by Airway Prostanoid Receptors
    DENNIS MCGRAW; Fiscal Year: 2006
    ..In Specific Aim 2, we will determine whether the EPt receptor is a mediator of bronchoconstriction and AHR...
  14. A NOVEL ELECTROPORATION SYSTEM FOR GENE THERAPY WITH EPO
    MAIDA DE LAS ALAS; Fiscal Year: 2002
    ..treatment-induced anemia in AIDS/HIV and chemotherapy patients using a proprietary TriGrid electroporation system (EPT)...
  15. ELECTROPORATION THERAPY OF HEPATOCELLULAR CARCINOMA
    Robert Bernard; Fiscal Year: 2000
    Electroporation Therapy with Bleomycin (EPT-B) holds promise for the treatment of primary and secondary liver cancer. By applying brief electrical pulses to tissue, transient increases in cell membrane permeability can be induced...
  16. DNA DAMAGE AND REPAIR BY ANTITUMOR AGENTS
    WARREN ROSS; Fiscal Year: 1990
    ..to topoisomerase II and DNA? The vpmR cell line is resistant to intercalating agents (1A) and epipodophyllotoxins (EPT) and bears a topoisomerase II which, upon purification, exhibits resistance to these agents as well...
  17. ELECTROPORATION THERAPY OF HEAD AND NECK CANCER
    Robert Bernard; Fiscal Year: 1999
    Electroporation Therapy (EPT) offers significant promise in the treatment of many solid tumors...
  18. Feasiblity Analysis of a Clinical Electroporation System
    Robert Bernard; Fiscal Year: 2003
    ..project is the development of automated equipment suitable for the clinical application of Electroporation Therapy (EPT)...
  19. Purchase of Bruker Pulse EPT Spectrometer
    David Cafiso; Fiscal Year: 2003
    ..abstract_text> ..
  20. New Broad-Acting Cell Wall Antibiotics for Biodefense
    ANIA KNAP; Fiscal Year: 2007
    ..In Phase I, we will focus on a novel chemical series that potently inhibits UDP-GlcNAc enolpyruvyl transferase (EPT), an essential, broadly conserved, bacterial-specific enzyme catalyzing the first committed step in peptidoglycan ..
  21. Combination cytokine gene therapy for melanoma treatment
    Alain Luxembourg; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Pilot studies of Ichor's Electroporation Therapy (EPT) suggest that it could provide an effective means of the delivery of plasmid DNA into tumor tissue...
  22. Broad Spectrum Agents Against Cat A Bacterial Pathogens
    ANIA KNAP; Fiscal Year: 2005
    ..We will focus on a novel chemical series that potently inhibits UDP-GlcNAc enolpyruvyl transferase (EPT), an essential, broadly conserved, bacterial-specific enzyme catalyzing the first committed step in peptidoglycan ..
  23. Mammographic Density and Invasive Breast Cancer
    Etta Pisano; Fiscal Year: 2006
    ..confirmed previous epidemiologic data, which suggested that, combined hormone therapy with estrogen and progestin (EPT) increases risk of breast cancer...
  24. Molecular Analysis of Epilepsy Predisposition
    John Cowell; Fiscal Year: 2006
    ..This is the LGI1 gene which was mutated in a small series of families showing linkage to chromosome region 10q24...
  25. GENETIC EPIDEMIOLOGY OF FAMILIAL EPILEPSY
    Ruth Ottman; Fiscal Year: 2001
    ..g., generalized epilepsy, localization-related epilepsy). ..
  26. GENETIC EPIDEMIOLOGY OF SEIZURE DISORDERS IN ROCHESTER
    Ruth Ottman; Fiscal Year: 2006
    ..abstract_text> ..
  27. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    We propose to continue investigation of the genetics of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure ..
  28. MATERNAL HEALTH STATUS AND ADVERSE BIRTH OUTCOMES
    Jennifer Haas; Fiscal Year: 2002
    ..Such interventions should begin from the premise that improved maternal and infant outcomes can only come from improved maternal health. ..
  29. Racial Segregation & Disparities in Cancer Outcomes
    Jennifer Haas; Fiscal Year: 2007
    ..The proposed study would provide empirical evidence that could give impetus to area-based interventions to reduce cancer disparities. ..
  30. Computerized EMR-Assisted Smoking Cessation (CEASCE)
    Jennifer Haas; Fiscal Year: 2007
    ..Future Directions: Evaluate whether CEASCE can serve as a prototype for other common primary care problems that require counseling for behavior change. [unreadable] [unreadable]..
  31. COLUMBIA UNIVERSITY SOUTHWEST ONCOLOGY GROUP PROGRAM
    Daniel Petrylak; Fiscal Year: 2003
    ..Based on substantial laboratory strength, we intend to integrate Columbia laboratory resources as core support for SWOG clinical studies. ..
  32. A community-level RCT of expedited partner treatment for gonorrhea and chlamydia
    Matthew R Golden; Fiscal Year: 2010
    ..Recent randomized controlled trials have demonstrated that expedited partner therapy (EPT), the practice of treating the sex partners of persons with curable STI without their mandatory prior examination ..
  33. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..therapy (ET) use is clearly associated with increased risk of ovarian cancer, estrogen plus progestin therapy (EPT) is associated with a statistically significant lower risk than ET...
  34. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  35. Steroid Hormone Genes and Ovarian Cancer Risk
    Mary Anne Rossing; Fiscal Year: 2010
    ..The proposed study, by expanding our knowledge of the role of progestogens, estrogens, and androgens in the development of ovarian cancer, will inform efforts to develop effective strategies to prevent this disease. ..
  36. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
  37. Use of Antidepressants and Risk of Breast Cancer
    MARY ROSSING; Fiscal Year: 2003
    ..g., SSRIs or tricyclics), and individual drugs such as fluoxetine and paroxetine. Use of the pharmacy database will provide unbiased and complete exposure data relative to previous studies based on self-reported drug use. ..
  38. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women. ..
  39. GENDER DIFFERENCES IN OSTEOPOROSIS
    Elizabeth Barrett Connor; Fiscal Year: 2002
    ....
  40. EPIDEMIOLOGY OF SMOKING CESSATION--GENETIC INFLUENCES
    MARY ROSSING; Fiscal Year: 2002
    ..In the future, such knowledge may allow the identification of subgroups of individuals who are most likely to benefit from particular pharmacologic interventions. ..
  41. Endogenous/Exogenous Sex Hormones & CHD Risk Factors
    Elizabeth Barrett Connor; Fiscal Year: 2003
    ..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
  42. PLASMALOGEN CATABOLISM DURING MYOCARDIAL ISCHEMIA
    David Ford; Fiscal Year: 2003
    ..Specific Aim 3 is to test the hypothesis that myocardial ischemia/reperfusion injury is mediated, in part, by plasmalogen degradation by reactive chlorinating species released from activated neutrophils. ..
  43. Evidence-based Principles of Treatment
    FRANK PEARSON; Fiscal Year: 2007
    ..g., with specific types of clients), and (2) the scientific strength and limitations of meta-analysis using current protocols and how this essential method can be improved. ..
  44. TSQ Quantum ESI-MS Surveyor Bundle
    David Ford; Fiscal Year: 2004
    ..This requested instrumentation will remedy this deficit in our otherwise well-equipped facility. ..
  45. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  46. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. Cognitive Recovery after Traumatic Brain Injury
    Maureen Schmitter Edgecombe; Fiscal Year: 2007
    ....
  48. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  49. HRT Decision Making in the Post-WHI Era
    Katherine Newton; Fiscal Year: 2006
    ..This study will provide key information about HRT decision making, and experiences with HRT discontinuation, in an era of increased scientific clarity about HRT's risks and benefits. [unreadable] [unreadable]..
  50. NEUROBIOLOGICAL EFFECT OF LONG-TERM ESTROGEN REPLACEMENT
    Yolanda Smith; Fiscal Year: 2006
    ..Comparison between groups will offer a greater understanding of the effect of hormone therapies on brain neurochemistry and cognition. ..
  51. Epidemiology of Ovarian Cancer:New Hypotheses
    MARY ROSSING; Fiscal Year: 2006
    ..abstract_text> ..
  52. Hereditary spastic paraplegia linked to chromosomes 8q
    Peter Hedera; Fiscal Year: 2006
    ..I will characterize the phenotype of transgenic animals. The study of a transgenic animal model will further enhance current state of knowledge about the pathophysiology of HSP and axonal degeneration. ..
  53. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  54. ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIAL
    Katherine Newton; Fiscal Year: 2004
    ....
  55. Immune Responses in Genital Chlamydia Prior to Therapy
    WILLIAM GEISLER; Fiscal Year: 2005
    ..abstract_text> ..
  56. Mammographic density, genes and estradiol/norethisterone based EPT regimens
    Giske Ursin; Fiscal Year: 2008
    ..clinical trial and observational epidemiologic studies strongly show that combined estrogen and progestin therapy (EPT) is associated with breast cancer risk...