LGI1

Summary

Gene Symbol: LGI1
Description: leucine-rich, glioma inactivated 1
Alias: ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, epitempin-1, leucine-rich glioma-inactivated protein 1
Species: human

Top Publications

  1. ncbi A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
    O B Chernova
    Department of Neurosciences NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Oncogene 17:2873-81. 1998
  2. ncbi Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization)
    Dietmar P Rabussay
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego CA 92121, USA
    Technol Cancer Res Treat 1:71-82. 2002
  3. ncbi Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families
    Pasquale Striano
    Epilepsy Center, Department of Neurological Sciences Federico II University, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 255:16-23. 2008
  4. doi Predicting the outcome of oral food challenges with hen's egg through skin test end-point titration
    S Tripodi
    Paediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
    Clin Exp Allergy 39:1225-33. 2009
  5. ncbi [Influence of 3.0 mm incision coaxial phacoemulsification and microincision cataract surgery (MICS) on corneal thickness]
    Edward Wylegała
    Z Zakładu Pielegniarstwa i Społecznych Problemów Medycznych Slaskiego Uniwersytetu Medycznego w Katowicach
    Klin Oczna 111:207-11. 2009
  6. ncbi Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene
    Padmaja Kunapuli
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, NY 14263, USA
    Oncogene 22:3985-91. 2003
  7. doi LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy
    Carlo Nobile
    Istituto di Neuroscienze del CNR, Sezione di Padova, Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Padova, Italy
    Hum Mutat 30:530-6. 2009
  8. pmc Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
    Sergey Kalachikov
    Columbia Genome Center, Columbia University, 630 W 168 Street, P and S Box 16, New York, New York 10032, USA
    Nat Genet 30:335-41. 2002
  9. ncbi A common protein interaction domain links two recently identified epilepsy genes
    Hartmut Scheel
    Bioinformatics Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Hum Mol Genet 11:1757-62. 2002
  10. ncbi Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission
    Yuko Fukata
    Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Science 313:1792-5. 2006

Detail Information

Publications139 found, 100 shown here

  1. ncbi A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
    O B Chernova
    Department of Neurosciences NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Oncogene 17:2873-81. 1998
    ..We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene-Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced ..
  2. ncbi Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization)
    Dietmar P Rabussay
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego CA 92121, USA
    Technol Cancer Res Treat 1:71-82. 2002
    ..Within 24-48 hours, the majority of tumor cells are rapidly destroyed by this bleomycin-electroporation therapy (B-EPT). This raises the concern that healthy tissue may be similarly affected...
  3. ncbi Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families
    Pasquale Striano
    Epilepsy Center, Department of Neurological Sciences Federico II University, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 255:16-23. 2008
    ..The genetics of this condition is largely unknown.We present the electroclinical and genetic findings of 15 MTLE Italian families...
  4. doi Predicting the outcome of oral food challenges with hen's egg through skin test end-point titration
    S Tripodi
    Paediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
    Clin Exp Allergy 39:1225-33. 2009
    ..Oral food challenge (OFC) is the diagnostic 'gold standard' of food allergies but it is laborious and time consuming. Attempts to predict a positive OFC through specific IgE assays or conventional skin tests so far gave suboptimal results...
  5. ncbi [Influence of 3.0 mm incision coaxial phacoemulsification and microincision cataract surgery (MICS) on corneal thickness]
    Edward Wylegała
    Z Zakładu Pielegniarstwa i Społecznych Problemów Medycznych Slaskiego Uniwersytetu Medycznego w Katowicach
    Klin Oczna 111:207-11. 2009
    ..To compare influence of two different cataract surgery methods on corneal thickness...
  6. ncbi Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene
    Padmaja Kunapuli
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, NY 14263, USA
    Oncogene 22:3985-91. 2003
    The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line...
  7. doi LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy
    Carlo Nobile
    Istituto di Neuroscienze del CNR, Sezione di Padova, Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Padova, Italy
    Hum Mutat 30:530-6. 2009
    Autosomal dominant lateral temporal epilepsy (ADLTE) or autosomal dominant partial epilepsy with auditory features (ADPEAF) is an inherited epileptic syndrome with onset in childhood/adolescence and benign evolution...
  8. pmc Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
    Sergey Kalachikov
    Columbia Genome Center, Columbia University, 630 W 168 Street, P and S Box 16, New York, New York 10032, USA
    Nat Genet 30:335-41. 2002
    ..we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with ..
  9. ncbi A common protein interaction domain links two recently identified epilepsy genes
    Hartmut Scheel
    Bioinformatics Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Hum Mol Genet 11:1757-62. 2002
    ..epilepsy, and the LGI1 gene, which is mutated in autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  10. ncbi Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission
    Yuko Fukata
    Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Science 313:1792-5. 2006
    ..However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1...
  11. pmc Localization of a gene for partial epilepsy to chromosome 10q
    R Ottman
    G H Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA
    Nat Genet 10:56-60. 1995
    ..83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval...
  12. pmc LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology
    Katherine Owuor
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 42:448-57. 2009
    ..ADAM11, nor some forms of ADAM22, contain PDZ-interacting sequences, suggesting PSD-95-independent mechanisms in ADPEAF. Because ADAMs modulate integrins, we examined LGI1 effect on neurite outgrowth...
  13. ncbi The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface
    María Salomé Sirerol-Piquer
    Unitat de Genetica Molecular, Departament de Genòmica i Proteòmica, Institut de Biomedicina de València CSIC, Spain
    Hum Mol Genet 15:3436-45. 2006
    ..b>ADLTE-related mutants of the long form are defective for secretion and are retained in the endoplasmic reticulum and ..
  14. doi A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy
    Pasquale Striano
    Muscular and Neurodegenerative Diseases Unit, Institute G Gaslini, University of Genoa, Genoa, Italy
    Arch Neurol 65:939-42. 2008
    Mutations responsible for autosomal dominant lateral temporal epilepsy have been found in the leucine-rich, glioma-inactivated 1 (LGI1) gene.
  15. ncbi LGI1 mutations in temporal lobe epilepsies
    S F Berkovic
    Epilepsy Research Institute and Department of Medicine, University of Melbourne, Victoria, Australia
    Neurology 62:1115-9. 2004
    ..have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  16. ncbi Two novel epilepsy-linked mutations leading to a loss of function of LGI1
    Elodie Chabrol
    INSERM UMR 679, Neurologie and Thérapeutique Expérimentale, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Arch Neurol 64:217-22. 2007
    Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy.
  17. ncbi Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy
    José M Morante-Redolat
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Jaume Roig 11, E 46010 Valencia, Spain
    Hum Mol Genet 11:1119-28. 2002
    ..Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder...
  18. ncbi LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures
    Wenli Gu
    Institute of Human Genetics, University Hospital Bonn, Bonn, Germany
    Ann Neurol 52:364-7. 2002
    ..lateral temporal lobe epilepsy previously has been linked to chromosome 10q22-q24, and recently mutations in the LGI1 gene (Leucine-rich gene, Glioma Inactivated) have been found in some autosomal dominant lateral temporal lobe ..
  19. pmc LGI1 mutations in autosomal dominant partial epilepsy with auditory features
    R Ottman
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 62:1120-6. 2004
    S: Mutations in LGI1 cause autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of familial temporal lobe epilepsy with auditory ictal manifestations...
  20. ncbi The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, D 13347 Berlin, Germany
    Trends Biochem Sci 27:441-4. 2002
    Recent studies suggest that mutations in the LGI1/Epitempin gene cause autosomal dominant lateral temporal epilepsy. This gene encodes a protein of unknown function, which we postulate is secreted...
  21. ncbi LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway
    Padmaja Kunapuli
    Roswell Park Cancer Institute, Department of Cancer Genetics, Buffalo, New York 14163, USA
    J Biol Chem 279:23151-7. 2004
    ..Progressive loss of LGI1 expression has been associated with the development of high grade gliomas...
  22. ncbi [Etiology of epilepsy in adolescents]
    J M Prats
    , Hospital de Cruces, Barakaldo, Vizcaya,
    Rev Neurol 28:32-5. 1999
    ..The latter included the Lennox-Gastaut syndrome, West syndrome, polymorphic epilepsy, etc. The etiology of these patients and related literature are reviewed in order to study the proper nosologic location of these entities...
  23. ncbi [Prognostic value of data from clinical, EEG and neuroimaging assessment in epilepsy with complex partial seizures]
    V Bertol
    , Hospital Miguel Servet, Zaragoza
    Rev Neurol 24:964-8. 1996
    ..9% and 73.7% more patient with hypersignal on long TR sequences in the group that did not decrease the frequency of their crisis to more than 50%...
  24. pmc Biofilm formation is not required for early-phase transmission of Yersinia pestis
    Sara M Vetter
    Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Microbiology 156:2216-25. 2010
    Early-phase transmission (EPT) is a recently described model of plague transmission that explains the rapid spread of disease from flea to mammal host during an epizootic...
  25. ncbi [Engineering and metabolic characteristics of a Clostridium tyrobutyricum strain]
    Guiqing Yang
    Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen, China
    Sheng Wu Gong Cheng Xue Bao 26:170-6. 2010
    ..tyrobutyricum. We fused these genes with pUC19 to construct nonreplicative integrated plasmids pUC19-EPT. Then we transformed pUC19-EPT into C. tyrobutyricum through electroporation...
  26. ncbi Assessing mercury exposure and effects to American dippers in headwater streams near mining sites
    Charles J Henny
    USGS Forest and Rangeland Ecosystem Science Center, Corvallis, OR 97331, USA
    Ecotoxicology 14:709-25. 2005
    ..the larval/nymph form of three Orders of aquatic macroinvertebrates (Ephemeroptera, Plecoptera and Trichoptera = EPT) important in their diet from three major headwater tributaries of the upper Willamette River, Oregon in 2002...
  27. ncbi Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families
    Roberto Michelucci
    Dipartimento di Neuroscienze, Divisione di Neurologia, Ospedale Bellaria e Università di Bologna, Bologna, Italy
    Epilepsia 44:1289-97. 2003
    corrected] To describe the clinical and genetic findings of seven additional pedigrees with autosomal dominant lateral temporal epilepsy (ADLTE).
  28. ncbi [Partial seizures during the course in patients with absence epilepsy]
    T Konishi
    Department of Pediatrics, Toyama Medical and Pharmaceutical University
    No To Hattatsu 31:395-401. 1999
    ..Our results suggest that localized cortical areas, especially the frontal lobe, are commonly involved in absence epilepsy. More detailed clinical observation is necessary to understand the pathogenesis of absence epilepsy...
  29. ncbi Increased gallbladder trypsin in acute cholecystitis indicates functional disorder in the sphincter of oddi and could make EPT a logical procedure
    Jozef Vracko
    University Medical Center, Ljubljana, Slovenia
    Surg Laparosc Endosc Percutan Tech 13:308-13. 2003
    ..Such a study is underway to assess the possible role of obstruction at, or other disorders of, the sphincter of Oddi with consequent pancreatic juice reflux into the gallbladder as a possible initial cause of ACh...
  30. ncbi Membrane lipid biosynthesis in Chlamydomonas reinhardtii: ethanolaminephosphotransferase is capable of synthesizing both phosphatidylcholine and phosphatidylethanolamine
    Wenyu Yang
    Department of Biological Sciences, Louisiana State University, Baton Rouge 70803, USA
    Arch Biochem Biophys 430:198-209. 2004
    ..A cDNA coding for diacylglycerol: CDP-ethanolamine ethanolaminephosphotransferase (EPT) was cloned from C. reinhardtii. The C...
  31. ncbi Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin
    E Schonbrunn
    Max Planck Unit for Structural Molecular Biology, Notkestr 85, c o DESY, D 22603 Hamburg, Germany
    Structure 4:1065-75. 1996
    ..One such enzyme is UDP-N-acetylglucosamine enolpyruvyltransferase (EPT) which catalyzes the first committed step in peptidoglycan biosynthesis: the transfer of the enolpyruvyl moiety of ..
  32. ncbi Chromogranins--new sensitive markers for neuroendocrine tumors
    B Eriksson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Acta Oncol 28:325-9. 1989
    ..of chromogranin A and chromogranin A + B by hormone-producing tumors in patients with endocrine pancreatic tumors (EPT), carcinoid tumors, pheochromocytomas and small cell lung cancer (SCLC)...
  33. doi A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women
    Michael J Gast
    Wyeth Pharmaceuticals, Collegeville, PA, USA
    Menopause 16:247-56. 2009
    To evaluate the effects of combined vaginal and oral low-dose estrogen plus progestogen therapy (EPT) on the frequency and severity of dyspareunia, sexual function, and quality of life in recently postmenopausal women.
  34. ncbi Nuclear DNA distribution in neuroendocrine gastroenteropancreatic tumors before and during treatment
    B Eriksson
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Acta Oncol 28:193-7. 1989
    ..of tumor cells in 73 patients with endocrine gastrointestinal tumors, 19 patients with endocrine pancreatic tumors (EPT) and 54 patients with malignant carcinoid tumors were determined before and after treatment...
  35. doi Biaxial microincision versus coaxial small-incision cataract surgery in complicated cases
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    J Cataract Refract Surg 36:66-72. 2010
    ....
  36. pmc Papillitis and the postcholecystectomy syndrome
    E Thomas
    Division of Gastroenterology, Veterans Administration Medical Center, Johnson City, TN 37684
    J Natl Med Assoc 84:238-40. 1992
    ..of papillitis may mimic that of papillary tumor and small distal common bile duct stone; endoscopic papillotomy (EPT) with biopsy may help clarify the diagnosis. In patients with delayed drainage, EPT may be therapeutic...
  37. ncbi Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans
    Eva Kosek
    Department of Surgical Sciences, Karolinska Institute Hospital, S 171 77 Stockholm, Sweden
    Pain 105:125-31. 2003
    ..corresponding to the perception threshold to innocuous electrical stimulation, the electrical pain threshold (EPT), and pain intensity rated as 2/10, 4/10 and 6/10, respectively...
  38. doi Long-term historical analysis of benthic communities and physical habitat in an agricultural stream in California's San Joaquin River watershed
    Lenwood W Hall
    Agricultural Experiment Station, Wye Research and Education Center, University of Maryland, Queenstown, Maryland 21658, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 44:543-56. 2009
    ..The metrics % predators, % EPT index, % collectors/filterers and % shredders were the benthic metrics that were most associated with the temporal ..
  39. doi Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila
    Ryosuke Midorikawa
    Research Group of Glycobiology and Glycotechnology, Mutant Flies Laboratory, Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    J Neurosci 30:10703-19. 2010
    ..Phosphatidylserine decarboxylase (Psd) and CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (Ept)...
  40. pmc Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair
    Sandra Amado
    Centro de Estudos de Ciência Animal CECA, Instituto de Ciências e Tecnologias Agrárias e Agro Alimentares ICETA, Universidade do Porto UP, Portugal
    J Neuroeng Rehabil 7:7. 2010
    ..Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics...
  41. pmc Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones
    Wen Hsiung Chang
    Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    World J Gastroenterol 11:593-6. 2005
    ..However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance...
  42. doi Colonization pattern of coagulase-negative staphylococci in preterm neonates and the relation to bacteremia
    M Bjorkqvist
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    Eur J Clin Microbiol Infect Dis 29:1085-93. 2010
    Coagulase-negative staphylococci (CoNS) are the major cause of sepsis in extreme preterm (EPT) newborns, but data on the CoNS colonization in EPT newborns prior to invasive infection are limited...
  43. ncbi The role of PET in localization of neuroendocrine and adrenocortical tumors
    Barbro Eriksson
    Department of Medical Sciences, Uppsala University PET Centre, University Hospital, S 751 85 Uppsala, Sweden
    Ann N Y Acad Sci 970:159-69. 2002
    ..Instead 5-HTP seems to be a universal tracer for EPT and foregut carcinoids...
  44. ncbi Studies employing Saccharomyces cerevisiae cpt1 and ept1 null mutants implicate the CPT1 gene in coordinate regulation of phospholipid biosynthesis
    S C Morash
    Department of Molecular Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 269:28769-76. 1994
    ..in CPT1 derived choline-phosphotransferase activity correlated with transcript levels in both wild type and ept- backgrounds...
  45. ncbi [Characteristics and indications of topiramate]
    M Nieto-Barrera
    Servicio de Neuropediatría Hospital Infantil Universitario Virgen del Rocio, Sevilla, Espana
    Rev Neurol 35:S88-95. 2002
    ..To do so, we have made use of an analysis of the literature, together with a multi centre study conducted in Spain and personal casuistry...
  46. ncbi [Choledochus revision in the age of endoscopic papillotomy. Indications and outcome]
    H Lauschke
    Klinik und Poliklinik für Allgemein, Viszeral, Thorax und Gefasschirurgie, Universitat Bonn
    Zentralbl Chir 126:364-8. 2001
    In the age of endoscopic papillotomy (EPT) the operative revision of the bile duct needs to be used stringently and interventional therapeutic options have to be considered primarily in the treatment of gallbladder and bile duct stone ..
  47. pmc Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains
    Tracy E Strecker
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, 68198, USA
    Genetics 169:2189-97. 2005
    ..These loci reside on chromosome 6 [Estrogen-induced pituitary tumor (Ept)1], chromosome 3 (Ept2 and Ept6), chromosome 10 (Ept9), and chromosome 1 (Ept10 and Ept13)...
  48. doi Rationale for using raloxifene to prevent both osteoporosis and breast cancer in postmenopausal women
    Wen Ling Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Chen Hsin Rehabilitation Center Taipei, Taiwan
    Maturitas 60:92-107. 2008
    ..In past decades, hormone therapy (HT), mainly estrogen plus progestin (EPT), has been frequently used for the purpose of preventing and treating postmenopausal osteoporosis because of its ..
  49. doi Inhibition of the renin-angiotensin system: effects on tachycardia-induced early electrical remodelling in rabbit atrium
    Roman Laszlo
    Department of Cardiology, University of Tubingen, Germany
    J Renin Angiotensin Aldosterone Syst 9:125-32. 2008
    ..Effects of a seven-day enalapril pre-treatment (EPT, 0...
  50. pmc Diclofenac prevents temporal increase of intraocular pressure after uneventful cataract surgery with longer operation time
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Sendai, Japan
    Clin Ophthalmol 3:95-101. 2009
    ....
  51. ncbi Trichothecene mycotoxins from Fusarium culmorum cultures
    N C Baldwin
    Department of Pharmacy, University of Nottingham, UK
    Z Naturforsch C 42:1043-9. 1987
    ..with 3,15-diacetyldeoxynivalenol, deoxynivalenol, calonectrin, isotrichodermin and 12,13-epoxytrichothec-9-ene (EPT) as minor products...
  52. ncbi Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 13:780-6. 2006
    To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women.
  53. ncbi Medroxyprogesterone acetate inhibits the cardioprotective effect of estrogen in experimental ischemia-reperfusion injury
    Helen L Jeanes
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Menopause 13:80-6. 2006
    Results from recent clinical trials of estrogen and progestogen therapy (EPT) suggest that some progestogens may interfere with the cardiovascular benefits of estrogen (E)...
  54. ncbi Separate myocardial ethanolamine phosphotransferase activities responsible for plasmenylethanolamine and phosphatidylethanolamine synthesis
    David A Ford
    Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, St Louis, MO 63104, USA
    J Lipid Res 44:554-9. 2003
    Ethanolamine phosphotransferase (EPT) is a key enzyme responsible for the synthesis of ethanolamine glycerophospholipids. Plasmenylethanolamine is a predominant molecular subclass of ethanolamine glycerophospholipids in the heart...
  55. ncbi Radiofrequency catheter ablation of Type 1 atrial flutter using a large-tip electrode catheter and high-power radiofrequency energy generator
    Gregory K Feld
    Cardiac Electrophysiology Program, University of California San Diego, 200 West Arbor Drive, 8411, San Diego, CA 92103, USA
    Expert Rev Med Devices 1:187-92. 2004
    ..b>EPT-1000 XP cardiac ablation system. There were 169 patients, aged 61 +/- 12 years involved...
  56. ncbi Seroprevalence of human immunodeficiency virus infection among tuberculosis patients in the Nylon district hospital tuberculosis treatment centre
    G E Sume
    Delegation of Public Health, Littoral Province, P O Box 106, Douala, Cameroon
    East Afr Med J 85:529-36. 2008
    ....
  57. doi A comparison of the activity profile and physiological demands between advanced and recreational veteran tennis players
    Jaime Fernandez-Fernandez
    Tennis Performance Research Group, Spanish Tennis Federation RFET, Barcelona, Spain
    J Strength Cond Res 23:604-10. 2009
    ..149.8 +/- 8.4 bpm), duration of rallies (DR) (6.3 +/- 4.1 vs. 7.6 +/- 5.5 seconds), and effective playing time (EPT) (21.7 +/- 5.0 vs. 23.6 +/- 5.4%), HR (148.3 +/- 11.5 vs. 149.8 +/- 8.4 bpm), and energy expenditure (263.1 +/- 49...
  58. ncbi Functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp
    Artur S P Varejao
    Department of Veterinary Sciences, CETAV, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    J Neurotrauma 21:1652-70. 2004
    ..Functional recovery was evaluated using the sciatic functional index (SFI), the extensor postural thrust (EPT) and the withdrawal reflex latency (WRL), before injury, and then at weekly intervals until week 8 postoperatively...
  59. doi Device for cataract analysis: development and relevance to cataract surgery
    Nobuhiko Chikamoto
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    J Cataract Refract Surg 36:58-65. 2010
    ..To evaluate the relationship between World Health Organization (WHO) cataract grade determined with a new device and (1) preoperative visual acuity and (2) the difficulty of specific steps in cataract surgery...
  60. pmc Activity patterns, blood lactate concentrations and ratings of perceived exertion during a professional singles tennis tournament
    Alberto Mendez-Villanueva
    Faculty of Physical Activity and Sport Sciences, Department of Didactics, University of Alcala, Madrid, Spain
    Br J Sports Med 41:296-300; discussion 300. 2007
    ..To examine the game characteristics and physiological (ie, blood lactate concentration) and perceptual (ie, rating of perceived exertion, RPE) responses during actual tennis competition in professional performers...
  61. ncbi Feasibility of bimanual microincision phacoemulsification in hard cataracts
    A Assaf
    Department of Ophthalmology, Ain Shams University, Nasr City, Cairo, Egypt
    Eye (Lond) 21:807-11. 2007
    ..The purpose of this work was to assess the feasibility of bimanual phacoemulsification in hard cataracts of N3+ using WhiteStar technology of Soveriegn (Advanced Medical Optics, Santa Ana, CA, USA)...
  62. ncbi Identification and characterization of human ethanolaminephosphotransferase1
    Yasuhiro Horibata
    Neuronal Circuit Mechanisms Research Group, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    J Lipid Res 48:503-8. 2007
    CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE)...
  63. ncbi Evaluation of variations in sensory and pain threshold assessments by electrocutaneous stimulation
    Irene Lund
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Physiother Theory Pract 21:81-92. 2005
    ..stimulation, PainMatcher (PM), was used to assess the electrical sensory thresholds (EST) and pain thresholds (EPT) in healthy volunteers and in patients with pain...
  64. doi Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features
    Olivier Corcos
    Pôle des Maladies de l Appareil Digestif, AP HP, Hopital Beaujon, Clichy, Paris, France
    Pancreas 37:85-93. 2008
    ..We aimed to assess (1) the accuracy of somatostatin receptor scintigraphy, (2) histological features with focus on malignancy and genotype-phenotype correlations, and (3) prognosis of VHL-EPT.
  65. ncbi Kinetic evidence for pentachlorophenol-dependent growth of a dehalogenating population in a pentachlorophenol- and acetate-fed methanogenic culture
    S L Stuart
    Department of Civil, Construction, and Environmental Engineering, Apperson Hall 202, Oregon State University, Corvallis, Oregon 97331, USA
    Biotechnol Bioeng 57:420-9. 1998
    ..The potential at a platinum electrode, EPt, was not controlled externally, but was maintained constant at -0.25 +/- 0.002 V (vs...
  66. ncbi Assessing relationships between human land uses and the decline of native mussels, fish, and macroinvertebrates in the Clinch and Powell River watershed, USA
    Jerome M Diamond
    Tetra Tech, Owings Mills, Maryland 21117, USA
    Environ Toxicol Chem 21:1147-55. 2002
    ..Both the Ephemeroptera, Plecoptera, Trichoptera (EPT) family-level index, and the fish index of biotic integrity (IBI) were lowest in a subwatershed with the greatest ..
  67. doi Development of the HLA proficiency testing for Central and East Europe
    K Bogunia-Kubik
    L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Int J Immunogenet 35:409-16. 2008
    In order to increase the reliability of histocompatibility testing, several external proficiency testing (EPT) schemes have been established within Europe...
  68. pmc Evolution of an international external quality assurance model to support laboratory investigation of Streptococcus pneumoniae, developed for the SIREVA project in Latin America, from 1993 to 2005
    Marguerite Lovgren
    National Centre for Streptococcus, Rm 1B3 26 WMC, Provincial Public Health Laboratory, 8440 112 St, Edmonton, T6G 2J2 Alberta, Canada
    J Clin Microbiol 45:3184-90. 2007
    ..by the National Centre for Streptococcus (NCS), Edmonton, Canada, and included external proficiency testing (EPT) and a validation process requiring regular submission of a sample of isolates from each laboratory to the NCS for ..
  69. ncbi Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis
    Takeshi Tokai
    Plant and Microbial Metabolic Engineering Research Unit, Discovery Research Institute DRI, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 353:412-7. 2007
    ..2), and a small amount of non-Fusarium trichothecene 12,13-epoxytrichothec-9-ene (EPT)...
  70. ncbi Training or EPT in perimenopause on balance and flushes
    Ingrid Bergström
    Center for Endocrinology, Metabolism and Diabetes, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:467-72. 2007
    ..balance function during the perimenopausal period, and evaluate the effect of estrogen plus progesterone therapy (EPT) or aerobic training on balance. Sixty perimenopausal women were recruited to the study...
  71. ncbi A BAC library for the goldfish Carassius auratus auratus (Cyprinidae, Cypriniformes)
    Jing Luo
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
    J Exp Zool B Mol Dev Evol 306:567-74. 2006
    ..Preliminary screens with two genes were conducted with hybridizing probes to the genes RAG1 and lgi1. RAG1 is a single-copy gene in zebrafish and is duplicated in C. a. auratus...
  72. ncbi The sn-1,2-diacylglycerol ethanolaminephosphotransferase activity of Saccharomyces cerevisiae. Isolation of mutants and cloning of the EPT1 gene
    R H Hjelmstad
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 263:19748-57. 1988
    ..to identify nine Saccharomyces cerevisiae mutants defective in in situ ethanolaminephosphotransferase activity (ept mutants). Genetic analysis revealed five complementation groups...
  73. ncbi Estrogen-progestin therapy in women after stem cell transplant: our experience and literature review
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Menopause 14:320-30. 2007
    ..Because of the likelihood of the need for long-lasting estrogen plus progestin therapy (EPT) and the increased risk of secondary neoplasia after SCT, the EPT should be as physiological as possible...
  74. ncbi A case of smoldering anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis with faciobrachial dystonic seizure
    Yuriko Nakaoku
    Department of Neurology, Kyoto University Graduate School of Medicine
    Rinsho Shinkeigaku 53:706-11. 2013
    We report a 59-year-old right-handed woman with smoldering leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis (LE) following faciobrachial dystonic seizures...
  75. ncbi The role of mammographic density in evaluating changes in breast cancer risk
    Malcolm C Pike
    USC Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Gynecol Endocrinol 21:1-5. 2005
    ..Women's Health Initiative (WHI) study showed that postmenopausal continuous combined estrogen-progestogen therapy (EPT) significantly increases the risk of breast cancer, thus confirming the results from large epidemiological studies...
  76. ncbi Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy)
    Christopher M Byrne
    The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown and Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia
    Melanoma Res 15:45-51. 2005
    Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells...
  77. ncbi Impervious surface area as a predictor of the effects of urbanization on stream insect communities in Maine, USA
    Chandler C Morse
    Department of Biological Sciences, University of Maine, Orono, Maine, USA
    Environ Monit Assess 89:95-127. 2003
    ..Streams draining catchments with PTIA < 6% had the highest levels of both total insect and EPT (Ephemeroptera + Plecoptera + Trichoptera) taxonomic richness...
  78. doi Hyperactive behavior in a family with autosomal dominant lateral temporal lobe epilepsy caused by a mutation in the LGI1/epitempin gene
    B Berghuis
    SEIN, Epilepsy Institute in the Netherlands, Zwolle, The Netherlands
    Epilepsy Behav 28:41-6. 2013
    Autosomal dominant lateral temporal lobe epilepsy (ADLTE) is characterized by focal seizures with auditory features or aphasia...
  79. ncbi Fostering federal and local disaster preparedness partnerships
    Lancer A Scott
    Medical University of South Carolina, Charleston, SC 29425, USA
    J S C Med Assoc 108:69-75. 2012
    ..included (1) a regional database of care providers to identify optimal emergency preparedness training (EPT) distribution, (2) an EPT assessment survey to gauge current care provider disaster preparedness, and (3) a high-..
  80. doi Response of corneal hysteresis and central corneal thickness following clear corneal cataract surgery
    Artemios Kandarakis
    Ophthalmiatrion Eye Hospital of Athens, Athens, Greece
    Acta Ophthalmol 90:526-9. 2012
    ..To evaluate the effect of routine phacoemulsification in corneal viscoelastic properties determined by corneal hysteresis (CH) and central corneal thickness (CCT) and to explore the impact of phaco energy on the above parameters...
  81. doi Distal esophageal spasm
    Sabine Roman
    Digestive Physiology, Claude Bernard Lyon I University, Lyon, France
    Dysphagia 27:115-23. 2012
    ..With the introduction of high-resolution manometry and esophageal pressure topography (EPT) in clinical practice, rapidly propagated contractions are nonspecific of esophageal spasm...
  82. pmc Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus
    Heather D VanGuilder Starkey
    Department of Pharmacology, Penn State University College of Medicine, 500 University Drive, R130, Hershey, PA 17033, USA
    Cell Mol Neurobiol 33:483-8. 2013
    ..Recent studies have identified two novel endogenous NgR1 antagonists, LOTUS and LGI1, and an alternative co-receptor, ADAM22, which act to suppress NgR1 pathway signaling...
  83. pmc Behavior disorders in extremely preterm/extremely low birth weight children in kindergarten
    Megan N Scott
    Department of Pediatrics, Rainbow Babies and Children s Hospital, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Dev Behav Pediatr 33:202-13. 2012
    To examine the prevalence of behavior disorders in a 2001-2003 birth cohort of extremely preterm/extremely low birth weight (EPT/ELBW, <28 weeks gestational age or <1000 g) children in kindergarten.
  84. doi A rat model for LGI1-related epilepsies
    Stephanie Baulac
    Inserm U975, CRicm, France
    Hum Mol Genet 21:3546-57. 2012
    Mutations of the leucine-rich glioma-inactivated 1 (LGI1) gene cause an autosomal dominant partial epilepsy with auditory features also known as autosomal-dominant lateral temporal lobe epilepsy...
  85. ncbi Electroporation enhances therapeutic efficacy of anticancer drugs: treatment of human pancreatic tumor in animal model
    G S Nanda
    Genetronics, Inc, San Diego, CA 92121, USA
    Anticancer Res 18:1361-6. 1998
    A new method of cancer treatment called electroporation therapy (EPT) which uses pulsed electric fields in combination with a chemotherapeutic agent is being developed to treat human pancreatic tumors...
  86. pmc The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women
    Kerstin L Edlefsen
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
    Menopause 17:622-9. 2010
    ..of hormone therapy (HT) and between users of estrogen therapy (ET) and users of estrogen + progesterone therapy (EPT) may relate to differences in serum hormone concentrations between these populations...
  87. ncbi Electroporation therapy: a new approach for the treatment of head and neck cancer
    G A Hofmann
    Genetronics, Inc, San Diego, CA 92121, USA
    IEEE Trans Biomed Eng 46:752-9. 1999
    ..The MedPulser, a new treatment system for local electroporation therapy (EPT) of head and neck tumors was developed and is described in this paper...
  88. pmc Sexual conflict predicts morphology and behavior in two species of penduline tits
    René E van Dijk
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    BMC Evol Biol 10:107. 2010
    ..two closely-related passerine birds with contrasting breeding systems: the Eurasian penduline tit Remiz pendulinus (EPT) exhibiting a highly polygamous breeding system with sexually antagonistic interests over parental care, and the ..
  89. ncbi Identification of the promoter, genomic structure, and mouse ortholog of LGI1
    R P Somerville
    Center for Molecular Genetics NB20, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Mamm Genome 11:622-7. 2000
    The human LGI1 gene is a leucine-rich, repeat-containing gene that was cloned from the t(10:19) breakpoint of the T98G glioblastoma cell line...
  90. doi Paroxetine increases brain-derived neurotrophic factor in postmenopausal women
    Alessandra Cubeddu
    Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy
    Menopause 17:338-43. 2010
    ....
  91. doi Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON-1
    Juan R Lopez
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Neuroendocrinology 91:131-41. 2010
    BON-1 is a human serotonin-producing endocrine pancreatic tumor (EPT) cell line, which has been used for various studies of tumorigenesis and treatment...
  92. doi The effect of transdermal testosterone on mammographic density in postmenopausal women not receiving systemic estrogen therapy
    Susan R Davis
    Women s Health Program, Department of Medicine, Central and Eastern Clinical School, Monash University, Alfred Hospital, Commercial Road, Prahran, Victoria 3181, Australia
    J Clin Endocrinol Metab 94:4907-13. 2009
    ..breast cancer risk and reduced diagnostic mammographic sensitivity and may be seen with estrogen/progestin therapy (EPT). The effects of testosterone therapy on mammographic density in postmenopausal women not on EPT are not known.
  93. doi Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain
    Vicente Herranz-Pérez
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Valencia, Spain CIBERNED
    Brain Res 1307:177-94. 2010
    The leucine-rich glioma inactivated (LGI) gene subfamily contains four highly conserved members (LGI1, 2, 3 and 4), which have been described in human, mouse and other mammalians...
  94. ncbi An update of the medical treatment of malignant endocrine pancreatic tumors
    B Eriksson
    Medical Department, University Hospital, Uppsala, Sweden
    Acta Oncol 32:203-8. 1993
    ..octreotide and combinations of treatment modalities in patients with malignant endocrine pancreatic tumor (EPT)...
  95. ncbi Variations of common bile duct diameter after endoscopic sphincterotomy
    B Persson
    Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden
    Gastrointest Radiol 16:45-8. 1991
    ..the common bile duct (CBD) and common hepatic duct (CHD) were measured before and after endoscopic sphincterotomy (EPT) in 100 patients. There was a significant reduction of the lumen diameter in both the CBD and CHD (p less than 0...
  96. pmc Evaluation of depression risk in LGI1 mutation carriers
    Gary A Heiman
    Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
    Epilepsia 51:1685-90. 2010
    ..this hypothesis by studying depressive symptoms in families with an identified genetic form of epilepsy: autosomal dominant partial epilepsy with auditory features caused by mutations in the leucine-rich, glioma inactivated 1 gene (LGI1).
  97. doi Concerted electron-proton transfer (EPT) in the oxidation of tryptophan with hydroxide as a base
    Christopher J Gagliardi
    Department of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599 3290, USA
    J Am Chem Soc 133:19594-7. 2011
    ..have been used to explore the roles of proton-coupled electron transfer and concerted electron-proton transfer (EPT) in tryptophan oxidation...
  98. pmc LGI2 truncation causes a remitting focal epilepsy in dogs
    Eija H Seppala
    Department of Veterinary Biosciences, Department of Medical Genetics, Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland
    PLoS Genet 7:e1002194. 2011
    ..3 where we identified a protein-truncating mutation in the Lgi2 gene, a homologue of the human epilepsy gene LGI1. We show that LGI2, like LGI1, is neuronally secreted and acts on metalloproteinase-lacking members of the ADAM ..
  99. doi Solid phase extraction of ultra traces mercury (II) using octadecyl silica membrane disks modified by 1,3-bis(2-ethoxyphenyl)triazene (EPT) ligand and determination by cold vapor atomic absorption spectrometry
    Mohammad Kazem Rofouei
    Faculty of Chemistry, Tarbiat Moallem University, Tehran, Iran
    J Hazard Mater 192:1358-63. 2011
    ..silica membrane disk was modified by the recently synthesized triazene ligand, 1,3-bis(2-ethoxyphenyl)triazene (EPT), and cold vapor atomic absorption spectrometry was used to determine the resultant preconcentrated Hg(II) ions...
  100. doi Quantitative conductivity and permittivity imaging of the human brain using electric properties tomography
    Tobias Voigt
    Department of Electrical Engineering and Information Technology, Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Magn Reson Med 66:456-66. 2011
    ..In this study, a recently developed approach, called electric properties tomography (EPT) is adapted for and applied to in vivo imaging...
  101. doi Follow-up studies of very low birthweight children in Sweden
    Per Olof Gäddlin
    Paediatric Clinic, Ryhov County Hospital, Jonkoping, Sweden
    Acta Paediatr 100:940-9. 2011
    Follow-up studies are essential to our knowledge of outcome in very low birthweight (VLBW) or extremely preterm (EPT) infants because those children have a greater risk for developing neurosensory disabilities and behavioural and ..

Research Grants21

  1. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..therapy (ET) use is clearly associated with increased risk of ovarian cancer, estrogen plus progestin therapy (EPT) is associated with a statistically significant lower risk than ET...
  2. Efficacy of Acupuncture with PT for Knee Osteo-Arthritis
    John Farrar; Fiscal Year: 2005
    ..trial evidence of efficacy for the standard treatments of acetaminophen and NSAIDs, and exercise physical therapy (EPT), which is usually added when the patient develops functional limitations...
  3. ENZYME INTERMEDIATE STRUCTURES BY NMR
    Michael Smerdon; Fiscal Year: 2002
    ..The project will be extended to include uridine diphosphate N-acetyl-glucosamine enolpyruvyl transferase (UDP-NAG EPT) and 3-deoxy-D-manno-2-octulosonate-8-phosphate (KD08P) synthase...
  4. Choline phosphotransferase-dependent phospholipid synthesis in Treponema
    J Fenno; Fiscal Year: 2009
    ..In many eukaryotes, this enzyme also has 1,2-diacylglycerol ethanolamine phosphotransferase (EPT) activity required for phosphatidylethanolamine (PtdEtn) synthesis. In T...
  5. Signaling and Crosstalk by Airway Prostanoid Receptors
    DENNIS MCGRAW; Fiscal Year: 2006
    ..In Specific Aim 2, we will determine whether the EPt receptor is a mediator of bronchoconstriction and AHR...
  6. A NOVEL ELECTROPORATION SYSTEM FOR GENE THERAPY WITH EPO
    MAIDA DE LAS ALAS; Fiscal Year: 2002
    ..treatment-induced anemia in AIDS/HIV and chemotherapy patients using a proprietary TriGrid electroporation system (EPT)...
  7. A community-level RCT of expedited partner treatment for gonorrhea and chlamydia
    Matthew R Golden; Fiscal Year: 2010
    ..Recent randomized controlled trials have demonstrated that expedited partner therapy (EPT), the practice of treating the sex partners of persons with curable STI without their mandatory prior examination ..
  8. ELECTROPORATION THERAPY OF HEPATOCELLULAR CARCINOMA
    Robert Bernard; Fiscal Year: 2000
    Electroporation Therapy with Bleomycin (EPT-B) holds promise for the treatment of primary and secondary liver cancer. By applying brief electrical pulses to tissue, transient increases in cell membrane permeability can be induced...
  9. DNA DAMAGE AND REPAIR BY ANTITUMOR AGENTS
    WARREN ROSS; Fiscal Year: 1990
    ..to topoisomerase II and DNA? The vpmR cell line is resistant to intercalating agents (1A) and epipodophyllotoxins (EPT) and bears a topoisomerase II which, upon purification, exhibits resistance to these agents as well...
  10. Feasiblity Analysis of a Clinical Electroporation System
    Robert Bernard; Fiscal Year: 2003
    ..project is the development of automated equipment suitable for the clinical application of Electroporation Therapy (EPT)...
  11. ELECTROPORATION THERAPY OF HEAD AND NECK CANCER
    Robert Bernard; Fiscal Year: 1999
    Electroporation Therapy (EPT) offers significant promise in the treatment of many solid tumors...
  12. Purchase of Bruker Pulse EPT Spectrometer
    David Cafiso; Fiscal Year: 2003
    ..abstract_text> ..
  13. Broad Spectrum Agents Against Cat A Bacterial Pathogens
    ANIA KNAP; Fiscal Year: 2005
    ..We will focus on a novel chemical series that potently inhibits UDP-GlcNAc enolpyruvyl transferase (EPT), an essential, broadly conserved, bacterial-specific enzyme catalyzing the first committed step in peptidoglycan ..
  14. Combination cytokine gene therapy for melanoma treatment
    Alain Luxembourg; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Pilot studies of Ichor's Electroporation Therapy (EPT) suggest that it could provide an effective means of the delivery of plasmid DNA into tumor tissue...
  15. New Broad-Acting Cell Wall Antibiotics for Biodefense
    ANIA KNAP; Fiscal Year: 2007
    ..In Phase I, we will focus on a novel chemical series that potently inhibits UDP-GlcNAc enolpyruvyl transferase (EPT), an essential, broadly conserved, bacterial-specific enzyme catalyzing the first committed step in peptidoglycan ..
  16. Mammographic Density and Invasive Breast Cancer
    Etta Pisano; Fiscal Year: 2006
    ..confirmed previous epidemiologic data, which suggested that, combined hormone therapy with estrogen and progestin (EPT) increases risk of breast cancer...
  17. Molecular Analysis of Epilepsy Predisposition
    John Cowell; Fiscal Year: 2006
    ..This is the LGI1 gene which was mutated in a small series of families showing linkage to chromosome region 10q24...
  18. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    We propose to continue investigation of the genetics of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure ..
  19. Mammographic density, genes and estradiol/norethisterone based EPT regimens
    Giske Ursin; Fiscal Year: 2008
    ..clinical trial and observational epidemiologic studies strongly show that combined estrogen and progestin therapy (EPT) is associated with breast cancer risk...