leucine rich alpha 2 glycoprotein

Summary

Gene Symbol: leucine rich alpha 2 glycoprotein
Description: leucine rich alpha-2-glycoprotein 1
Alias: HMFT1766, LRG, leucine-rich alpha-2-glycoprotein, 1300008B03Rik, 2310031E04Rik, leucine rich alpha 2 glycoprotein
Species: human

Top Publications

  1. ncbi Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation
    Lynn C O'donnell
    Bone Marrow Transplant Program, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    J Leukoc Biol 72:478-85. 2002
  2. ncbi Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay
    Chad Cummings
    Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN, USA
    Apoptosis 11:1121-9. 2006
  3. doi Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response
    Ryoichi Shirai
    Laboratory of Biochemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Biochem Biophys Res Commun 382:776-9. 2009
  4. doi Brain localization of leucine-rich α2-glycoprotein and its role
    Madoka Nakajima
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 113:97-101. 2012
  5. doi Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Inflamm Bowel Dis 18:2169-79. 2012
  6. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
  7. doi Laparoscopic remnant gastrectomy as a novel approach for treatment of gastrogastric fistula
    Jayaraj Salimath
    The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA
    Surg Endosc 23:2591-5. 2009
  8. pmc The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens
    Oliver Liesenfeld
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e20568. 2011
  9. doi High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration
    R G Kay
    Drug Development Services, Quotient BioResearch Ltd, Fordham CB7 5WW, UK
    Rapid Commun Mass Spectrom 23:3173-82. 2009
  10. ncbi Anemia in pregnancy and race in the United States: blacks at risk
    Omoniyi Y Adebisi
    Department of Family Medicine, University of Tennessee, Memphis, TN, USA
    Fam Med 37:655-62. 2005

Research Grants

Scientific Experts

Detail Information

Publications153 found, 100 shown here

  1. ncbi Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation
    Lynn C O'donnell
    Bone Marrow Transplant Program, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    J Leukoc Biol 72:478-85. 2002
    ..Expression of LRG during differentiation of 32Dcl3G cells preceded the expression of lactoferrin and gelatinase but followed ..
  2. ncbi Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay
    Chad Cummings
    Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN, USA
    Apoptosis 11:1121-9. 2006
    ..This identification may lead to a modified ELISA to quantify total Cyt c in patients' sera. LRalpha2GP1 is the first extracellular ligand for Cyt c that has been identified. A physiological function associated with binding is suggested...
  3. doi Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response
    Ryoichi Shirai
    Laboratory of Biochemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Biochem Biophys Res Commun 382:776-9. 2009
    Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered...
  4. doi Brain localization of leucine-rich α2-glycoprotein and its role
    Madoka Nakajima
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 113:97-101. 2012
    We have previously reported that the level of leucine-rich alpha-2-glycoprotein (LRG) expression is specifically increased in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus (INPH)...
  5. doi Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Inflamm Bowel Dis 18:2169-79. 2012
    ..This study aimed to investigate whether levels of serum leucine-rich alpha-2 glycoprotein (LRG), identified recently as a potential disease activity marker in Crohn's disease and rheumatoid arthritis, correlate ..
  6. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
    ..In addition, the transcriptome was precipitated with an antibody against RNA polymerase II and real-time polymerase chain reaction assay (Q-PCR) was used to confirm some of the BCG-specific transcripts...
  7. doi Laparoscopic remnant gastrectomy as a novel approach for treatment of gastrogastric fistula
    Jayaraj Salimath
    The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA
    Surg Endosc 23:2591-5. 2009
    ..We have previously reported a GGF rate of 1.5% after divided RYGBP. Remnant gastrectomy has been advocated by our group as a treatment option for this complication. We report our initial experience using the laparoscopic approach...
  8. pmc The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens
    Oliver Liesenfeld
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e20568. 2011
    ..Experiments with mice genetically deficient in members of this family such as Irgm1(LRG-47), Irgm3(IGTP), and Irgd(IRG-47) has revealed a critical role in microbial clearance, especially for Toxoplasma ..
  9. doi High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration
    R G Kay
    Drug Development Services, Quotient BioResearch Ltd, Fordham CB7 5WW, UK
    Rapid Commun Mass Spectrom 23:3173-82. 2009
    ..The protein leucine-rich alpha-2-glycoprotein (LRG) was recently identified as a putative biomarker of rhGH administration...
  10. ncbi Anemia in pregnancy and race in the United States: blacks at risk
    Omoniyi Y Adebisi
    Department of Family Medicine, University of Tennessee, Memphis, TN, USA
    Fam Med 37:655-62. 2005
    ....
  11. pmc LRG-accelerated differentiation defines unique G-CSFR signaling pathways downstream of PU.1 and C/EBPepsilon that modulate neutrophil activation
    Jing Ai
    Davis Heart and Lung Research Institute and Division of Hematology Oncology, The Ohio State University College of Medicine, Columbus, OH 43210 1240, USA
    J Leukoc Biol 83:1277-85. 2008
    Expression of leucine-rich alpha2 glycoprotein (LRG), a member of the leucine-rich repeat family of proteins, was recently shown to be up-regulated during neutrophil differentiation...
  12. ncbi Identification of a lipopolysaccharide inducible transcription factor in murine macrophages
    B E Drysdale
    Department of Research Service, Baltimore VA Medical Center, MD 21201, USA
    Mol Immunol 33:989-98. 1996
    ..7. By differential screening, a gene, designated LRG-21, was identified that showed nucleic acid sequence homology to rat liver regenerating factor-1 (LRF-1) and human ..
  13. ncbi Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)
    Stanley C Henry
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Durham, NC 27705, USA
    J Immunol 179:6963-72. 2007
    ..Current data indicate that the IRG protein Irgm1 (LRG-47) is critical for resistance to intracellular bacteria...
  14. doi Effects of mandibular advancement on upper airway dimension and collapsibility in patients with obstructive sleep apnea using dynamic upper airway imaging during sleep
    Jae Kap Choi
    Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, Korea
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:712-9. 2010
    ....
  15. pmc The Streptococcus mutans Cid and Lrg systems modulate virulence traits in response to multiple environmental signals
    Sang Joon Ahn
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Microbiology 156:3136-47. 2010
    ..Analysis of S. mutans lrg and cid mutants revealed a role for these operons in autolysis, biofilm formation, glucosyltransferase expression ..
  16. ncbi Sequence variation in two ipaH genes of Shigella flexneri 5 and homology to the LRG-like family of proteins
    M M Venkatesan
    Department of Bacterial Immunology, Walter Reed Army Institute of Research, Washington, D C 20307 5100
    Mol Microbiol 5:2435-45. 1991
    ..8, characteristic of members of the leucine-rich glycoprotein (LRG) family. The DNA sequences of ipaH2.5 and ipaH1.4 indicate that these genes are truncated versions of ipaH7.8...
  17. ncbi Prioritisation by physicians in the Netherlands--the growth hormone example in drug reimbursement decisions
    Antoinette de Bont
    Department of Health Policy and Management, Erasmus MC, Post Box 1738, 3000 DR Rotterdam, The Netherlands
    Health Policy 80:369-77. 2007
    ..This paper assesses the National Registry of Growth Hormone Treatment (LRG) responsible for making prioritisation decisions in the Dutch drug reimbursement system in the treatment of growth ..
  18. pmc Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection
    Korana Musicki
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 74:3180-9. 2006
    ..of mRNAs for several chemokines as well as the macrophage effector molecules inducible nitric oxide synthase and LRG-47 in the livers of memTNF mice but not in the livers of WT mice...
  19. ncbi Characterization of CidR-mediated regulation in Bacillus anthracis reveals a previously undetected role of S-layer proteins as murein hydrolases
    Jong Sam Ahn
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Mol Microbiol 62:1158-69. 2006
    ..As in S. aureus, the cidR mutation affected expression of the B. anthracis cid and lrg homologues, murein hydrolase activity and cell viability in stationary phase...
  20. ncbi [Comparison of the present and previously used protocol of risk stratification in children with acute lymphoblastic leukemia]
    Eliza Glodkowska
    Katedra i Klinika Hematologii i Onkologii, Akademia Medyczna, ul Marszałkowska 24, 00 576 Warszawa, Poland
    Med Wieku Rozwoj 11:153-8. 2007
    ..Acute lymphoblastic leukaemia (ALL) is one of the most common cancers in children. In Poland, since November 2002 a new protocol of risk stratification has been recommended for assessment of risk factors and for choosing therapy regimens...
  21. pmc Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma
    Yeng Chen
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Hematol Oncol 2:37. 2009
    ..ACT), clusterin (CLU), alpha1-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported...
  22. pmc STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection
    L Cristina Gavrilescu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 72:1257-64. 2004
    ..fail to upregulate the IFN-gamma-dependent effector molecules inducible nitric oxide synthase (iNOS), IGTP, and LRG-47, which are required for mice to survive infection...
  23. ncbi Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3
    M J Hickey
    Seattle Veterans Administration Medical Center, WA 98108
    FEBS Lett 274:189-92. 1990
    ..of 16 amino acids and a mature protein of 160 amino acids that includes a 24 amino acid leucine-rich glycoprotein (LRG) segment...
  24. ncbi Scoring patients' risk in differentiated thyroid cancer
    T Hadjieva
    Radiotherapy Department, University Hospital Queen Giovanna, Faculty of Medicine, Sofia, Bulgaria
    Onkologie 24:561-8. 2001
    ..Despite of excellent long-term results, there is a need for the selection of patients with differentiated thyroid cancer who experience an unfavorable outcome...
  25. ncbi Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones
    M Setoguchi
    Department of Pathology, Medical College of Oita, Japan
    Biochim Biophys Acta 1008:213-22. 1989
    ..5%), and contained four putative N-glycosylation sites. Mouse CD14 showed 13 building blocks, of which internal nine blocks have a conserved leucine motif and significant homology with human leucine-rich alpha 2-glycoprotein...
  26. ncbi Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae
    O Roumanie
    Laboratoire de Biologie Moleculaire et de Sequencage, Institut de Biochimie et Génétique Cellulaires, UMR CNRS 5095, P O Box 64, 146 rue Leo Saignat, 33076 Cedex, Bordeaux, France
    FEBS Lett 506:149-56. 2001
    ..In addition, we brought the first evidence for the existence of a sixth functional Rho in yeast, the Cdc42/Rac-like GTPase Rho5...
  27. pmc Transcription of the Staphylococcus aureus cid and lrg murein hydrolase regulators is affected by sigma factor B
    Kelly C Rice
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844 3052, USA
    J Bacteriol 186:3029-37. 2004
    The Staphylococcus aureus lrg and cid loci are homologous operons that have been shown to regulate murein hydrolase activity and affect sensitivity to penicillin...
  28. ncbi Analysis of potential diagnostic biomarkers in cerebrospinal fluid of idiopathic normal pressure hydrocephalus by proteomics
    X Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 148:859-64; discussion 864. 2006
    ..The present study investigated the disease-specific proteins that aid in the diagnosis and treatment of INPH and thus to study their role in the disease process...
  29. pmc Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques
    Jayme L Wiederin
    University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Proteome Res 9:4721-31. 2010
    ..Observed changes in plasma proteins expression likely represent a compensatory host response to persistent viral infection...
  30. doi Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier
    Chaodong Wang
    Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming 365000, Fujian, China
    Mol Immunol 53:43-51. 2013
    ..In an in vivo EAE mouse model, we have shown that Irgm1 (also known as LRG-47), a member of the immunity-related GTPase family, promotes the disruption of both BCSFB and BBB, and exacerbates ..
  31. doi Relative potencies of aroclor mixtures derived from avian in vitro bioassays: comparisons with calculated toxic equivalents
    Rui Zhang
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, PR China, 210023
    Environ Sci Technol 47:8852-61. 2013
    ..Recently, a luciferase reporter gene (LRG) assay, measuring aryl hydrocarbon receptor 1 (AHR1)-mediated gene expression, accurately predicted the relative ..
  32. pmc Leucine-rich α2-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortex
    Masakazu Miyajima
    Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e74453. 2013
    Leucine-rich α2-glycoprotein (LRG) is a protein induced by inflammation. It contains a leucine-rich repeat (LRR) structure and easily binds with other molecules...
  33. pmc Metastasis suppressor microRNA-335 targets the formin family of actin nucleators
    Jennifer Lynch
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, Dublin, Ireland National Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    PLoS ONE 8:e78428. 2013
    ..We conclude that miR-335 is a master regulator of tumour cell migration and invasion by directly targeting a plethora of genes that effectively control cell migratory processes. ..
  34. doi In vitro assay for the toxicity of silver nanoparticles using heart and gill cell lines of Catla catla and gill cell line of Labeo rohita
    G Taju
    OIE Reference Laboratory for WTD, Aquaculture Biotechnology Laboratory, PG and Research Department of Zoology, C Abdul Hakeem College, Melvisharam, Tamil Nadu 632 509, India
    Comp Biochem Physiol C Toxicol Pharmacol 161:41-52. 2014
    ..catla heart cell line (SICH), Indian C. catla gill cell line (ICG) and L. rohita gill cell line (LRG) was assessed using MTT and neutral red (NR) assay...
  35. pmc Proteome changes in the plasma of myelodysplastic syndrome patients with refractory anemia with excess blasts subtype 2
    Pavel Májek
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    Dis Markers 2014:178709. 2014
    ..Increased expression and changes in modification(s) were observed for LRAG, a protein involved in granulocytic and neutrophil differentiation, and angiogenesis. ..
  36. pmc A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva
    Rebeca Kawahara
    Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil
    Proteomics 16:159-73. 2016
    ..Overall, this study successfully used targeted proteomics to measure in saliva a panel of biomarker candidates for OSCC. ..
  37. ncbi [Expression of LRG-1 in clinical specimens and Tca8113 cell line of tongue carcinoma]
    Li Jing Hao
    Department of Dentistry, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China E mail
    Nan Fang Yi Ke Da Xue Xue Bao 36:297-302. 2016
    To investigate the expression of LRG-1 in clinical specimens and Tca8113 cell line of tongue carcinoma and analyze the relationship between LRG-1 expression and the clinicopathological parameters.
  38. pmc LRG1 downregulation in allergic airway disorders and its expression in peripheral blood and tissue cells
    Lijing Hao
    Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University, No 2, Sect 5, Renmin Street, Guta District, Jinzhou, 121001, Liaoning, People s Republic of China
    J Transl Med 14:202. 2016
    ..Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in plasma of individuals with various diseases. However, the role of LRG1 in allergic airway disease has not been investigated...
  39. pmc Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis
    Shinichiro Shinzaki
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Crohns Colitis 11:84-91. 2017
    ..We previously reported that serum leucine-rich alpha-2 glycoprotein [LRG] was a novel biomarker for rheumatoid arthritis and IBD...
  40. doi LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome
    Diana E Ramirez-Ardila
    Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Electronic address
    Mol Oncol 10:1363-73. 2016
    ..This study now evaluates whether expression of mRNAs and miRs are linked to PIK3CA genotype and are independently related to AI therapy response in order to define potential expressed biomarkers for treatment outcome...
  41. ncbi Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction
    Bibiana Fabre
    Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica Universidad de Buenos Aires Email
    Asian Pac J Cancer Prev 17:3167-71. 2016
    ..between cortisol, leptin and estrogens in 141 men, 71 with PCa and the remaining 70 constituting a low risk group (LRG)...
  42. pmc Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues
    Jinglin L Xie
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 12:e1006405. 2016
    ..albicans morphogenesis, and illuminate functional relationships that govern activation of a central transducer of signals that control environmental response and virulence programs...
  43. pmc Evidence of viscerally-mediated cold-defence thermoeffector responses in man
    Nathan B Morris
    Thermal Ergonomics Laboratory, Faculty of Health Sciences, University of Sydney, NSW, Australia
    J Physiol . 2016
    ..However, the cold-defence thermoeffector response patterns differed from previously identified hot-defence thermoeffectors...
  44. doi Downregulation of leucine‑rich‑α‑2‑glycoprotein 1 expression is associated with the tumorigenesis of head and neck squamous cell carcinoma
    Yongping Wang
    Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P R China
    Oncol Rep . 2017
    ..These findings imply that downregulation of the expression of LRG1 is correlated with tumorigenesis but not with the development of HNSCC, indicating the potential clinical value of LRG1 in the early diagnosis of HNSCC...
  45. ncbi The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats
    F Tan
    Laboratory of Peptide Research, University of Illinois College of Medicine, Chicago 60612
    J Biol Chem 265:13-9. 1990
    ..The leucine-rich domain likely constitutes an important structural or functional element in the interactions of the 83- and 50-kDa subunits to form the active tetramer of carboxypeptidase N...
  46. ncbi Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family
    K C McFarland
    Department of Developmental Biology, Genetech, Inc, South San Francisco, CA 94080
    Science 245:494-9. 1989
    ..domain displaying an internal repeat structure characteristic of members of the leucine-rich glycoprotein (LRG) family, and a 333-residue region containing seven transmembrane segments...
  47. ncbi Chemotactic behavior of Chlamydomonas reinhardtii is altered during gametogenesis
    Elena V Ermilova
    Laboratory of Microbiology, Biological Research Institute of St Petersburg University, Oranienbaumskoe schosse 2, Stary Peterhof, St Petersburg, 198504 Russia
    Curr Microbiol 46:261-4. 2003
    ..These data indicate that there are common components in the signaling pathways that control change of chemotactic behavior and forming of mating competence in gametes...
  48. ncbi Inflammation of the cystic fibrosis mouse small intestine
    Oxana Norkina
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 286:G1032-41. 2004
    ..Immune cell infiltration was confirmed histologically by staining for mast cells and neutrophils. These data demonstrate that the CF intestine exhibits an inflammatory state with upregulation of components of the innate immune system...
  49. ncbi Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
    E E Gardiner
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC Australia
    J Thromb Haemost 5:1530-7. 2007
    ..Platelet glycoprotein (GP)VI that binds collagen, and GPIb-IX-V that binds von Willebrand factor, initiate thrombus formation...
  50. pmc Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation
    Ethan E Mann
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 4:e5822. 2009
    ..In flow-cell assays, both cid and lrg mutations had dramatic effects on biofilm maturation and tower formation...
  51. doi Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension
    Jianqiang Zhang
    Research Center for Pathology and Physiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei Li Shi Road, Xi Cheng District, Beijing 100037, China
    Respir Med 103:1801-6. 2009
    ..The present study investigated the disease-specific proteins that aid in the diagnosis of IPAH and thus to study their role in the disease process...
  52. doi Effect of different microcystin profiles on toxin bioaccumulation in common carp (Cyprinus carpio) larvae via Artemia nauplii
    Issam El Ghazali
    Department of Biology, Laboratory of Biology and Biotechnology of Microorganisms, Microbiology and Environmental Toxicology Unit, Faculty of Sciences Semlalia Marrakech, University Cadi Ayyad, PO Box 2390, Marrakech 40000, Morocco
    Ecotoxicol Environ Saf 73:762-70. 2010
    ..The MC concentration in the nauplii was 73.60+/-7.88ngEqMC-LRg(-1)FW (n=4, mean+/-SE) for bloom A and 87.04+/-10.31ngEqMC-LRg(-1)FW for bloom B...
  53. doi Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury
    Fabienne Aregger
    Department of Nephrology Hypertension, Inselspital, University of Bern, Bern, Switzerland
    J Thorac Cardiovasc Surg 139:692-700. 2010
    ..Acute kidney injury is a well-known complication with high morbidity and mortality after cardiopulmonary bypass. Cardiopulmonary bypass-associated acute kidney injury is still poorly understood...
  54. doi Comparative proteomics, network analysis and post-translational modification identification reveal differential profiles of plasma Con A-bound glycoprotein biomarkers in gastric cancer
    Yih Huei Uen
    Superintendent s Office, Chi Mei Hospital Chiali, Tainan 722, Taiwan
    J Proteomics 83:197-213. 2013
    ..Additionally, three novel PTMs in ITIH3 were identified and include hexose-N-acetyl-hexosamine at asparagine-(41), trimethylation at aspartic acid-(290), and flavin adenine dinucleotide at histidine-(335)...
  55. doi LRG1 is an independent prognostic factor for endometrial carcinoma
    Shan Yun Wen
    Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yisan Road, Shanghai, 200233, People s Republic of China
    Tumour Biol 35:7125-33. 2014
    ..Thus, LRG1 potentially offered clinical value in directing personal treatment for endometrial carcinoma patients. ..
  56. doi In vitro cytotoxic, genotoxic and oxidative stress of cypermethrin on five fish cell lines
    G Taju
    OIE Reference Laboratory for WTD, PG and Research Department of Zoology, C Abdul Hakeem College, Melvisharam, 632 509 Vellore District, Tamilnadu, India
    Pestic Biochem Physiol 113:15-24. 2014
    ..a study was conducted for the assessment of cytotoxic, genotoxic and oxidative stress of CYP in IEG, CB, ICG, LRG and CSG cell lines at 24h exposure...
  57. doi Targeted mass spectrometry analysis of the proteins IGF1, IGF2, IBP2, IBP3 and A2GL by blood protein precipitation
    Gerard Such-Sanmartín
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Proteomics 113:29-37. 2015
    ..We benchmarked this method for the analysis of 40 individual blood samples including 20 patients diagnosed with breast cancer...
  58. doi Stable knockdown of LRG1 by RNA interference inhibits growth and promotes apoptosis of glioblastoma cells in vitro and in vivo
    Di Zhong
    Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    Tumour Biol 36:4271-8. 2015
    ....
  59. pmc The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice
    Adrian M Stankiewicz
    Department of Animal Behaviour, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland
    PLoS ONE 10:e0142195. 2015
    ..Our study suggests that some of the previously reported, supposedly specific changes in hippocampal gene expression, may be a result of the inclusion of choroid plexus in the hippocampal samples. ..
  60. doi Discovery of potential colorectal cancer serum biomarkers through quantitative proteomics on the colonic tissue interstitial fluids from the AOM-DSS mouse model
    Yang Wang
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China
    J Proteomics 132:31-40. 2016
    ..These data demonstrate that coupling dynamic TIF proteomics with targeted serum proteomics in an animal model is a promising avenue for pursuing the discovery of tumor serum biomarkers...
  61. pmc Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus
    Jin Hyung Lee
    School of Chemical Engineering, Yeungnam University, Gyeongsan, 712 749, Republic of Korea
    Sci Rep 6:19267. 2016
    ..the α-hemolysin hla gene, biofilm-related genes (psmα, rbf, and spa), and modulated the expressions of cid/lrg genes (the holin/antiholin system)...
  62. pmc LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation
    Jingjing Zhang
    State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, 200001, China
    J Exp Clin Cancer Res 35:29. 2016
    ..Here, we investigated the biological function and underlying molecular mechanisms of LRG1 in CRC...
  63. doi YsbA and LytST are essential for pyruvate utilization in Bacillus subtilis
    Marielle H van den Esker
    Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
    Environ Microbiol 19:83-94. 2017
    The genome of Bacillus subtilis encodes homologues of the Cid/Lrg network. In other bacterial species, this network consists of holin- and antiholin-like proteins that regulate cell death by controlling murein hydrolase activity...
  64. pmc LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain
    Hongmei Meng
    Department of Pathology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P R China
    Mol Med Rep 14:5535-5543. 2016
    ..This may provide a potential therapeutic target for the treatment of ischemic stroke...
  65. pmc Leucine Rich α-2 Glycoprotein: A Novel Neutrophil Granule Protein and Modulator of Myelopoiesis
    Lawrence J Druhan
    The Department of Hematologic Oncology, The Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, United States of America
    PLoS ONE 12:e0170261. 2017
    ....
  66. ncbi Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae
    A Lorberg
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Geb 26 12, 40225 Dusseldorf, Germany
    Mol Genet Genomics 266:514-26. 2001
    ..We therefore suggest that Lrg1p acts as a negative regulator of the Pkc1p pathway in conjunction with its known homologue Sac7p...
  67. ncbi Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker
    Koichi Saito
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, 565 0871, Osaka, Japan
    J Immunol 168:1050-9. 2002
    ....
  68. ncbi [Biochemistry of platelet membrane glycoproteins]
    Yasuhiko Ando
    Department of Laboratory Medicine, School of Medicine, Tokai University
    Nihon Rinsho 61:547-51. 2003
    ..and sequenced and have been found to be members of major gene families, such as integrin, leucine rich glycoprotein (LRG), selectin, etc. In this chapter, the structure and the functions of membrane glycoproteins are briefly reviewed.
  69. ncbi Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    John D MacMicking
    Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 302:654-9. 2003
    ..Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against disease...
  70. ncbi Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    Maximiliano G Gutierrez
    Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza 5500, Argentina
    Cell 119:753-66. 2004
    ..IFN-gamma induced autophagy in macrophages, and so did transfection with LRG-47, an effector of IFN-gamma required for antimycobacterial action...
  71. pmc p47 GTPases regulate Toxoplasma gondii survival in activated macrophages
    Barbara A Butcher
    Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Infect Immun 73:3278-86. 2005
    ..We have shown previously that IGTP and LRG-47, members of the IFN-gamma-regulated family of p47 GTPases, are required for resistance to acute T...
  72. ncbi Risk score model for fatal intracranial hemorrhage in acute leukemia
    H Kim
    Division of Hematology Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
    Leukemia 20:770-6. 2006
    ..The RS model segregated patients into three prognostic groups: a low-risk group (LRG) for RS of 0 or 1; an intermediate-risk group (IRG) for RS of 2 or 3; and a high-risk group (HRG) for RS of 4 or 5...
  73. ncbi Characterization of the Staphylococcus aureus CidR regulon: elucidation of a novel role for acetoin metabolism in cell death and lysis
    Soo Jin Yang
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844 3052, USA
    Mol Microbiol 60:458-68. 2006
    The Staphylococcus aureus cid and lrg operons encode a novel regulatory system that affects murein hydrolase activity, stationary-phase survival and antibiotic tolerance...
  74. ncbi STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells
    Antonio Gigliotti Rothfuchs
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 176:6982-90. 2006
    ..Nonhemopoietic cells accounted for the expression of STAT1-mediated indoleamine 2, 3-dioxygenase and the p47 GTPase LRG-47, but not inducible NO synthase mRNA...
  75. ncbi Autophagy as an immune defense mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Curr Opin Immunol 18:375-82. 2006
    ..has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase lrgm1 (LRG-47), which has a protective role against Mycobacterium tuberculosis...
  76. ncbi Human IRGM induces autophagy to eliminate intracellular mycobacteria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Science 313:1438-41. 2006
    ..We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the ..
  77. ncbi Effect of normothermic perfusion using fructose-1,6-bisphosphate for maintenance of liver function during in situ extended hepatectomy by the total hepatic vascular exclusion technique
    Ryuichiro Uemura
    Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    J Surg Res 137:89-95. 2007
    ..We evaluated the effect of normothermic liver perfusion with the addition of fructose-1, 6-bisphosphate (FBP) and oxygenation to maintain liver parenchymal, non-parenchymal, and Kupffer cell function...
  78. pmc Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry
    Tione Buranda
    Department of Pathology and Cancer Center, University of New Mexico Health Science Center, Albuquerque, New Mexico, USA
    Methods Enzymol 461:227-47. 2009
    ..ligands (L) to G-protein-coupled receptors (GPCRs) initiates the formation of ternary complexes with G-proteins (LRG complexes). We describe the assembly of detergent-solubilized LRG complexes on beads...
  79. pmc Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry
    Alex Kentsis
    Division of Emergency Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Ann Emerg Med 55:62-70.e4. 2010
    ..Here, we sought to profile the urine of patients with appendicitis, with the goal of identifying new diagnostic markers...
  80. ncbi Comparison of the microbial quality of ground beef and ground beef patties from internet and local retail markets
    S Pao
    Virginia State University, Agricultural Research Station, P O Box 9061, Petersburg, Virginia, USA
    J Food Prot 72:1722-6. 2009
    ..S.) retail markets. A total of 152 ground beef products, consisting of locally purchased raw ground beef (LRG) and frozen beef patties (LFP) and Internet-procured frozen ground beef (IFG) and frozen beef patties (IFP), were ..
  81. doi Effect of elevation resolution on evapotranspiration simulations using MODFLOW
    B V N P Kambhammettu
    Department of Civil Engineering, New Mexico State University, Las Cruces, NM 88003, USA
    Ground Water 50:367-75. 2012
    ..Applicability of the research is tested for the lower Rio Grande (LRG) Basin in southern New Mexico...
  82. doi Loss of the plastid envelope protein AtLrgB causes spontaneous chlorotic cell death in Arabidopsis thaliana
    Mizuki Yamaguchi
    Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan
    Plant Cell Physiol 53:125-34. 2012
    ..The phenotypes of atlrgB resembled those in lesion mimic mutants, suggesting that AtLrgB functions against cell death, similar to the bacterial Lrg system.
  83. doi Proteomic identification of plasma biomarkers in uterine leiomyoma
    Chao Po Lin
    Department of Obstetrics and Gynecology, Chiayi Christian Hospital, Chiayi, Taiwan
    Mol Biosyst 8:1136-45. 2012
    ..The potential of utilizing these markers for screening and treating uterine leiomyomas warrants further investigations...
  84. pmc Novel serum and urine markers for pediatric appendicitis
    Anupam B Kharbanda
    Division of Pediatric Emergency Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Acad Emerg Med 19:56-62. 2012
    The objective was to describe the association between two novel biomarkers, calprotectin and leucine-rich alpha glycoprotein-1 (LRG), and appendicitis in children.
  85. pmc MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway
    Jennifer Lynch
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    Carcinogenesis 33:976-85. 2012
    ..Our results provide novel insight into the direct regulation of TGF-β non-canonical signaling by miR-335, which in turn is downregulated by MYCN...
  86. pmc Paralogous annotation of disease-causing variants in long QT syndrome genes
    James S Ware
    Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom
    Hum Mutat 33:1188-91. 2012
    ..org/Paralogue_Annotation/), based on newly created Locus Reference Genomic sequences (http://www.lrg-sequence.org/). We propose that paralogous annotation is widely applicable for Mendelian human disease genes.
  87. ncbi Evaluation of mental status HIV-infected patients: implications for treatment
    Y H Jin
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Curr HIV Res 10:546-51. 2012
    ....
  88. doi A luciferase reporter gene assay and aryl hydrocarbon receptor 1 genotype predict the LD50 of polychlorinated biphenyls in avian species
    Gillian E Manning
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Toxicol Appl Pharmacol 263:390-401. 2012
    ..A luciferase reporter gene (LRG) assay was developed in our laboratory to measure AHR1-mediated induction of a cytochrome P450 1A5 reporter gene in ..
  89. pmc Integrative proteomics and tissue microarray profiling indicate the association between overexpressed serum proteins and non-small cell lung cancer
    Yansheng Liu
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e51748. 2012
    ..We revealed that A1BG and LRG1 were overexpressed in both the blood level and tumor sections, which can be referred to separate lung cancer patients from healthy cases...
  90. doi Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma
    Chun Liang Tung
    Department of Pathology, Chiayi Christian Hospital, Chiayi, Taiwan
    J Pharm Biomed Anal 75:7-17. 2013
    ..The potential of utilizing these markers for screening and treating OSCC warrants further investigations...
  91. doi Serum protein profile of Crohn's disease treated with infliximab
    Maria Gazouli
    Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Greece Laboratory of Cell and Gene Therapy Foundation for Biomedical Research of the Academy of Athens IIBEAA, Greece Electronic address
    J Crohns Colitis 7:e461-70. 2013
    ....
  92. pmc Identification of O-glycosylated proteins that are aberrantly excreted in the urine of patients with early stage ovarian cancer
    Alan Kang Wai Mu
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Int J Mol Sci 14:7923-31. 2013
    ....
  93. pmc LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
    Xiaomeng Wang
    Department of Cell Biology, UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Nature 499:306-11. 2013
    ..LRG1 antibody blockade inhibits this switch and attenuates angiogenesis. These studies reveal a new regulator of angiogenesis that mediates its effect by modulating TGF-β signalling. ..
  94. ncbi The primary structure of the core protein of the small, leucine-rich proteoglycan (PG I) from bovine articular cartilage
    P J Neame
    Shriners Hospital for Crippled Children, University of South Florida, Tampa, Florida 33612
    J Biol Chem 264:8653-61. 1989
    ..shown that for PG II, the majority of domain 3 shows considerable similarity to leucine-rich alpha 2-glycoprotein (LRG) from serum. Domain 2 of PG I or PG II also has an analog in LRG, in that it has two cysteines in a similar place...
  95. pmc Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures
    M J Hickey
    Hematology Section, Seattle Veterans Administration Medical Center, WA 98108
    Proc Natl Acad Sci U S A 86:6773-7. 1989
    ..GPIX contains a leucine-rich glycoprotein (LRG) sequence of 24 amino acids similar to conserved LRG sequences in GPIb and other proteins from humans, Drosophila, ..
  96. pmc The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence
    J A Lopez
    Department of Biochemistry, University of Washington, Seattle
    Proc Natl Acad Sci U S A 85:2135-9. 1988
    ..The intracellular segment contains an unpaired cysteine and two potential sites for phosphorylation by cAMP-dependent protein kinase...
  97. ncbi Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family
    J M Sorace
    Department of Pathology, Baltimore VA Medical Center, Maryland 21201, USA
    J Leukoc Biol 58:477-84. 1995
    ..7 macrophage cell line cDNA library to isolate and characterize LPS-induced messages. One such message, LRG-47, is induced by LPS, IFN-gamma, and IFN-alpha/beta, but not by a panel of other cytokines or pharmacological ..
  98. pmc Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins
    M J Hickey
    Hematology Section, Seattle Veterans Administration Medical Center, WA 98105
    Proc Natl Acad Sci U S A 90:8327-31. 1993
    ..System members share physical associations, leucine-rich glycoprotein (LRG) structures, and a congenital deficiency state, Bernard-Soulier syndrome...
  99. ncbi Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV
    T Takafuta
    Department of Internal Medicine, Hiroshima University, Japan
    Thromb Haemost 72:762-9. 1994
    ..V (GPV) is a platelet membrane protein with a molecular weight of 82 kD, and one of the leucine rich glycoproteins (LRG)...
  100. ncbi Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma
    G A Taylor
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 271:20399-405. 1996
    ..In addition, the protein was homologous to proteins encoded by three previously cloned cDNAs, IRG-47, TGTP/Mg21, and LRG-47, and thus may be representative of a new family of interferon gamma-regulated GTPases.
  101. ncbi Characterization of the gene encoding mouse platelet glycoprotien Ib beta
    T Kitaguchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Thromb Res 87:235-44. 1997
    ..The promoter region contained putative GATA and ets binding motif implicated in megakaryocytic expression. Mouse GPIb beta also contained a leucine-rich glycoprotein (LRG) sequence of 24 amino acids same as human GPIb beta.

Research Grants13

  1. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    ..To this end, a developmental research project is proposed that initiates study of the cid and lrg genes in S...
  2. Shirley ShiDu Yan; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): LRG-47 (Irgm1), also known p47GTPase, is an interferon (IFN)-?-inducible family of intracellular 47 kDa GTPases...
  3. The molecular control of bacterial autolysis
    Kenneth W Bayles; Fiscal Year: 2012
    The Staphylococcus aureus cid and lrg operons encode a novel regulatory system that is important in the control bacterial death and lysis...
  4. LRG-47: a critical regulator of host defense and hematopoietic stem cell function
    Megan P Tierney; Fiscal Year: 2010
    ..IFN-y signaling induces many downstream targets, including the p47 family of GTPases. LRG-47, a member of the murine p47 family, is critical for host response to intracellular bacteria and protozoa...
  5. Role of IFN-gamma Induced Macrophage GTPases in Brucella Killing
    James Cardelli; Fiscal Year: 2007
    ..in IFN-gamma treated macrophages contained increased levels of GTPases belonging to different families, including LRG-47 and GBP-5. Overexpression of LRG-47 attenuated B...
  6. LIGAND-RECEPTOR-G PROTEIN DYNAMICS & NEUTROPHIL RESPONSE
    Larry Sklar; Fiscal Year: 1992
    ..neutrophil, whose G is a novel protein which activates phospholipase C, is an ideal model system in which to study LRG dynamics...
  7. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  8. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  9. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  10. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  11. NEURODEGENERATIVE MECHANISMS IN ALZHEIMER'S DISEASE
    Piruz Nahreini; Fiscal Year: 2004
    ....
  12. Biomarkers with Biological Function in Ovarian Carcinoma
    Amy Skubitz; Fiscal Year: 2009
    ..The association between levels of expression/secretion of the cell adhesion proteins with biological functional activities and patient information will be determined. ..