leptin receptor

Summary

Gene Symbol: leptin receptor
Description: leptin receptor
Alias: CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor, OB receptor, huB219
Species: human

Top Publications

  1. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
  2. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
  3. pmc Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Int J Cancer 122:1611-7. 2008
  4. pmc Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 59:611-8. 2010
  5. pmc A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Clin Invest 121:1191-8. 2011
  6. doi Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 31:1093-100. 2008
  7. ncbi Modulation of direct leptin signaling by soluble leptin receptor
    Guoqing Yang
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    Mol Endocrinol 18:1354-62. 2004
  8. pmc Adipokine genes and prostate cancer risk
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 124:869-76. 2009
  9. doi No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk
    Lauren R Teras
    Department of Epidemiology, American Cancer Society, National Home Office, 250 Williams Street Northwest, Atlanta, GA 30303, USA
    Cancer Epidemiol Biomarkers Prev 18:2553-7. 2009
  10. ncbi Leptin receptor long-form signalling in a human liver cell line
    C P Briscoe
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK
    Cytokine 14:225-9. 2001

Research Grants

  1. Barry E Levin; Fiscal Year: 2015
  2. Lawrence P Reagan; Fiscal Year: 2016
  3. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
  4. Abba J Kastin; Fiscal Year: 2014
  5. Sensory Controls of Hyperphagia in Obesity
    Gary Schwartz; Fiscal Year: 2009
  6. Obese diabetic (type II) mouse model without leptin/leptin-receptor defects
    Richard G Peterson; Fiscal Year: 2013
  7. Orexin and Leptin Regulation of Feeding and Addictive Behavior in the VTA
    Michael Scott; Fiscal Year: 2010
  8. Orexin and Leptin Regulation of Feeding and Addictive Behavior in the VTA
    Michael Scott; Fiscal Year: 2013
  9. Margaret B Allison; Fiscal Year: 2014
  10. LEPTIN RECEPTOR AND THE OBESITY/DIABETES SYNDROME
    Streamson C Chua; Fiscal Year: 2010

Detail Information

Publications254 found, 100 shown here

  1. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
    ..library was prepared from mouse choroid plexus and screened with a leptin-AP fusion protein to identify a leptin receptor (OB-R)...
  2. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    ....
  3. pmc Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Int J Cancer 122:1611-7. 2008
    ..We evaluated the LEP rs2167270 (19 G > A) and rs7799039 (-2548 G > A) polymorphisms and the leptin receptor, LEPR rs6588147 (located in intron 2), polymorphism with risk of developing colon cancer in a study of 1,567 ..
  4. pmc Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 59:611-8. 2010
    We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two ..
  5. pmc A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Clin Invest 121:1191-8. 2011
    ..histolytica every other day over 9 years and evaluated them for genetic variants in leptin (LEP) and the leptin receptor (LEPR)...
  6. doi Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 31:1093-100. 2008
    ..We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity...
  7. ncbi Modulation of direct leptin signaling by soluble leptin receptor
    Guoqing Yang
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    Mol Endocrinol 18:1354-62. 2004
    Soluble leptin receptor (SLR) represents the major leptin binding activity in plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding of membrane-spanning receptors...
  8. pmc Adipokine genes and prostate cancer risk
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 124:869-76. 2009
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis...
  9. doi No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk
    Lauren R Teras
    Department of Epidemiology, American Cancer Society, National Home Office, 250 Williams Street Northwest, Atlanta, GA 30303, USA
    Cancer Epidemiol Biomarkers Prev 18:2553-7. 2009
    ..the association between postmenopausal breast cancer and variability in the genes encoding leptin, the leptin receptor, adiponectin, adiponectin receptor 1, and adiponectin receptor 2...
  10. ncbi Leptin receptor long-form signalling in a human liver cell line
    C P Briscoe
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK
    Cytokine 14:225-9. 2001
    Expression of the long form of the leptin receptor was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting in the human liver cell line WRL68...
  11. doi Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associated with hypertensive disorders in pregnancy
    Annette Wiedemann
    Department of Obstetrics and Gynecology Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Reprod Immunol 63:310-7. 2010
    ..Therefore, we investigated polymorphisms in the genes encoding leptin, the leptin receptor, and PPARgamma2 in patients with PIH.
  12. ncbi Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
    ..One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin...
  13. ncbi A role for leptin and its cognate receptor in hematopoiesis
    B D Bennett
    Department of Molecular Oncology, Genentech Inc, 460 Point San Bruno Blvd, South San Francisco, California 94080, USA
    Curr Biol 6:1170-80. 1996
    ..In this study, we have undertaken a search for novel cytokines that may influence the fate of hematopoietic stem cells...
  14. ncbi Association between leptin receptor gene polymorphisms and early-onset prostate cancer
    Z Kote-Jarai
    Translational Cancer Genetics, and Molecular Epidemiology, The Institute of Cancer Research, Surrey, UK
    BJU Int 92:109-12. 2003
    To report a case-control study examining the relationship between polymorphisms in the leptin receptor (OBR) gene and the development of young-onset prostate cancer, because epidemiological studies report that prostate cancer risk is ..
  15. doi Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity
    Einosuke Mizuta
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Japan
    Hypertens Res 31:1069-77. 2008
    ..investigated the associations among sweet preference, obesity, and polymorphisms of the leptin gene (LEP) or leptin receptor gene (LEPR)...
  16. ncbi Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway
    Sandrine Belouzard
    Unité Propre de Recherche 2511, Institut de Biologie de Lille, CNRS, 59021 Lille, France
    J Biol Chem 279:28499-508. 2004
    The leptin receptor is mainly localized in intracellular compartments in target tissues...
  17. ncbi Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer
    Mariusz Koda
    Department of General and Clinical Pathomorphology, Medical University of Bialystok, Waszyngtona St 13, 15 269 Bialystok, Poland
    Ann N Y Acad Sci 1095:90-8. 2007
    Recent studies suggested that Ob (Ob) and its receptor (ObR) could be involved in the pathogenesis of various human malignancies, among others in endometrial cancer...
  18. doi No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
    Julie Bienertova-Vasku
    Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Nutr Neurosci 11:2-8. 2008
    ..The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in the obese and non-obese Czech ..
  19. ncbi Single nucleotide polymorphism and lifestyle-related diseases in the Asia-Pacific region: comparative study in Okinawa, Palau and Thailand
    Y Kagawa
    High Technology Centre, Department of Medical Chemistry and Nutrition Clinic, Kagawa Nutrition University, Chiyoda Sakado, Saitama 350 0288, Japan
    Asia Pac J Public Health 15:S10-4. 2003
    ..four populations, in both men and women: uncoupling protein 2 (UCP2), uncoupling protein 3 promoter (UCP3p), leptin receptor (LEPR) exon 6, and angiotensinogen (AGTa-20c)...
  20. ncbi Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
    D B Thompson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85016, USA
    Hum Mol Genet 6:675-9. 1997
    ..We have physically localized the human leptin receptor gene (LEPR) to a region at 1p31, between the anonymous microsatellite markers D1S515 and D1S198...
  21. ncbi Exonic and intronic sequence variation in the human leptin receptor gene (LEPR)
    W K Chung
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York, USA
    Diabetes 46:1509-11. 1997
  22. ncbi A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
    M Heo
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Obes Relat Metab Disord 26:640-6. 2002
    We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of LEPR with body mass index (BMI; kg/m(2)) and waist circumference (WC)...
  23. ncbi Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin
    Markus Laimer
    Department of Medicine, University of Innsbruck, Austria
    Obes Res 10:597-601. 2002
    Soluble leptin receptor (sOB-R) represents the main binding site for leptin in human blood...
  24. ncbi Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults
    Caroline T M van Rossum
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Obes Res 11:377-86. 2003
    To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain.
  25. ncbi Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:2838-43. 2003
    ..These data suggest that adiponectin and sOB-R levels might be influenced by common regulatory factors and challenge the notion that cortisol may have a direct inhibitory effect on adiponectin in humans...
  26. ncbi Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    Makoto Ishikawa
    Department of Surgery, Division of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:4325-31. 2004
    To evaluate leptin and leptin receptor (OB-R) expression in human breast cancer and determine whether it could be effective for the prevention and treatment of breast cancer.
  27. ncbi Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 30:183-90. 2006
    ..Leptin (LEP) is an endocrine hormone that participates in many metabolic pathways, including those associated with the central regulation of energy homeostasis...
  28. ncbi Contribution of leptin receptor N-linked glycans to leptin binding
    Yuichi Kamikubo
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 410:595-604. 2008
    The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated...
  29. ncbi A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    ..Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family...
  30. ncbi SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
    C Bjorbak
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, and Section on Obesity, Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 275:40649-57. 2000
    During leptin signaling, each of the phosphorylated tyrosine residues on the long form of the leptin receptor (LRb) mediates distinct signals...
  31. ncbi LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women
    O Mammes
    Xavier Bichat Medicine School, Paris, France
    Eur J Clin Invest 31:398-404. 2001
    In humans, a mutation of the leptin receptor gene (LEPR) leads to a rare obese syndrome of mendelian inheritance. However, obesity in humans results from interactions between genes and environment, mainly nutritional factors...
  32. ncbi The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability
    N Yiannakouris
    Department of Home Economics, Harokopio University, 17671 Athens, Greece
    J Clin Endocrinol Metab 86:4434-9. 2001
    Genetic variation at the leptin receptor gene locus may play an important role in the pathophysiology of human obesity, a leptin-resistant state...
  33. ncbi Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans
    V Ogier
    Department of Human Nutrition, Ecole Nationale Supérieure d Agronomie et des Industries, Alimentairs, Vandoeuve les Nancy, France
    Int J Obes Relat Metab Disord 26:496-503. 2002
    ..It circulates in both free and bound form. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin...
  34. ncbi Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    Jean L Chan
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 51:2105-12. 2002
    ..A circulating soluble form of the leptin receptor [soluble leptin receptor (sOB-R)] is the main leptin-binding protein and determinant of free leptin index (..
  35. ncbi Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
    Hongfei Ge
    Touchstone Center for Diabetes Research, Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    J Biol Chem 277:45898-903. 2002
    ..Genetically obese rodents with mutations of leptin or leptin receptor develop morbid obesity and diabetes...
  36. ncbi Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 87:4587-94. 2002
    ..is bound in human blood by a high affinity binding protein, which appears to be identical with the soluble leptin receptor (sOB-R)...
  37. ncbi Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men
    Akiko Takahashi-Yasuno
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes Res Clin Pract 62:169-75. 2003
    To investigate whether leptin receptor (Ob-R) Arg223Gln polymorphism influences serum lipid levels and whether this polymorphism affects the efficiency of the cholesterol lowering HMG-CoA reductase inhibitor, simvastatin [Clin. Cardiol...
  38. ncbi Leptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk
    M Muy-Rivera
    Center for Perinatal Studies, Swedish Medical Center, School of Public Health and Communiity Medicine, University of Washington, 747 Broadway Suite 4 North, Seattle, WA 98122, USA
    Physiol Res 54:167-74. 2005
    Few investigators have simultaneously evaluated leptin, soluble leptin receptor (SLR) and leptin gene polymorphisms in preeclampsia cases and controls. We examined these three biomolecular markers in 40 preeclampsia cases and 39 controls...
  39. ncbi Genetics of leptin and obesity: a HuGE review
    Valentina Paracchini
    Unit of Molecular and Genetic Epidemiology, Fondazione Policlinico IRCCS, Milan, Italy
    Am J Epidemiol 162:101-14. 2005
    ..Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG ..
  40. ncbi Influence of nutritional recovery on the leptin axis in severely malnourished children
    Katja Stein
    Institute of Nutrition, Friedrich Schiller University, Dornburger Strasse 24, D 07743 Jena, Germany
    J Clin Endocrinol Metab 91:1021-6. 2006
    Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood.
  41. ncbi Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli
    Cecilia Garofalo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 12:1447-53. 2006
    ..system could become a target in breast cancer therapy, we examined the expression of leptin and its receptor (ObR) in primary and metastatic breast cancer and noncancer mammary epithelium...
  42. ncbi Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels
    Yuan Yuan Zhang
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Atherosclerosis 191:121-7. 2007
    ..To investigate this hypothesis, we examined the effect of genetic variability at the leptin receptor (LEPR) locus on the plasma levels of fibrinogen and CRP--two markers of inflammation and susceptibility to ..
  43. ncbi Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain
    Olga Portoles
    Genetic and Molecular Epidemiology Unit Department of Preventive Medicine and Public Health School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Eur J Epidemiol 21:605-12. 2006
    ..In animal models, the leptin (LEP) and the leptin receptor (LEPR) genes have been shown to be very important in obesity because leptin functions as a negative feedback ..
  44. ncbi Leptin receptor gene polymorphisms in severely pre-eclamptic women
    Janos Rigo
    First Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary
    Gynecol Endocrinol 22:521-5. 2006
    Variants of the leptin receptor gene (LEPR) may modulate the effect of elevated serum leptin levels in pre-eclampsia...
  45. ncbi The Gln223Arg polymorphism of the leptin receptor gene and peripheral blood/bone marrow leptin level in leukemic children
    M Wasik
    Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 57:375-83. 2006
    ..Leptin also plays a role in hematopoiesis, cell cycle regulation, and in oncogenesis. The leptin receptor is a single transmembrane protein belonging to the superfamily of cytokine receptors, structurally related to ..
  46. ncbi LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity
    Hatice Mergen
    Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara, Turkey
    Endocr J 54:89-94. 2007
    ..in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair ..
  47. ncbi Expression of leptin and leptin receptor in the testis of fertile and infertile patients
    T Ishikawa
    Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Andrologia 39:22-7. 2007
    The aim of our study was to investigate the relationships between the expression of leptin, leptin receptor in the testis and spermatogenesis, and testosterone (T) concentration in infertile men...
  48. ncbi Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease
    Lisa Gallicchio
    Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, Mercy Medical Center, 227 St Paul Place, Baltimore, MD 21202, USA
    Cancer Detect Prev 31:95-101. 2007
    ....
  49. ncbi Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007
    ..leptin concentrations and colorectal adenoma risk; in addition, we evaluated the relationship between leptin receptor polymorphisms and adenoma risk...
  50. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ..2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself...
  51. doi Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly
    Maria Gabriela Valle Gottlieb
    Programa de Pós Graduação em Medicina e Ciências da Saúde da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
    Metab Syndr Relat Disord 7:341-8. 2009
    ..Aging and gene-environmental interactions are involved in the pathophysiology of metabolic syndrome. The LEPR gene Gln223Arg polymorphism has been associated with energy metabolism and body weight...
  52. doi LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients
    Samir Ben Ali
    Biochemistry Department, Research Laboratory LR99ES11, Rabta University Hospital, Tunis, Tunisia
    Arch Med Res 40:186-90. 2009
    The leptin receptor (LEPR) plays a crucial role in the regulation of body weight. Several common polymorphisms have been described in the human LEPR gene including the p.Q223R polymorphism (rs1137101)...
  53. pmc Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival
    Rebecca J Cleveland
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Breast Cancer Res Treat 120:745-52. 2010
    ..Leptin exerts its effects through interaction with the leptin receptor (LEPR)...
  54. pmc No association of LEPR Gln223Arg polymorphism with leptin, obesity or metabolic disturbances in children
    B Pyrzak
    Department of Pediatrics and Endocrinology, Warsaw Medical University, Warsaw, Poland
    Eur J Med Res 14:201-4. 2009
    The aim of the study was to investigate whether the Gln223Arg in the leptin receptor may influence body weight, leptin concentration, and metabolic parameters in children.
  55. doi The 223A>G polymorphism of the leptin receptor gene is associated with macroangiopathy in type 2 diabetes mellitus
    Run tao Gan
    Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Str, Nangang District, Harbin, 150001, People s Republic of China
    Mol Biol Rep 39:4759-64. 2012
    To determine whether leptin receptor (LEPR) 223A>G polymorphism has an effect on the plasma leptin levels and the macroangiopathic complications in type 2 diabetes mellitus (T2DM)...
  56. doi The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients
    Yuliang Li
    Second Affiliated Hospital of Shandong University, BeiYuan Road 247, Jinan City, 250033, Shandong Province, People s Republic of China
    J Cancer Res Clin Oncol 138:311-6. 2012
    Although the role of genetic polymorphisms of leptin receptor (LEPR) gene in several cancers has been documented, the association between polymorphisms of LEPR gene and lung cancer remains unknown.
  57. pmc Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action
    Michael Schaab
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e34787. 2012
    The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans...
  58. pmc Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers
    Imen Boumaiza
    Department of Biochemistry, UR MSP 28 04, Sahloul University Hospital, Sousse, Tunisia
    Genet Test Mol Biomarkers 16:726-33. 2012
    ..studies tried to establish the relationship between obesity and the common polymorphisms of leptin (LEP) and leptin receptor (LEPR) genes, but results were controversial...
  59. doi Synergistic effect of LEP and LEPR gene polymorphism on body mass index in a Chinese population
    Jin Lu
    Department of Endocrinology, Changhai Hospital, Shanghai, China Electronic
    Obes Res Clin Pract 7:e445-9. 2013
    Both leptin (LEP) and leptin receptor (LEPR) are important in the regulation of body weight...
  60. ncbi Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction
    J A Cioffi
    Progenitor, Inc, Columbus, Ohio 43212, USA
    Nat Med 2:585-9. 1996
    ..B219/obr is expressed in the yolk sac, early fetal liver, enriched hematopoietic stem cells and in a variety of ..
  61. ncbi Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity
    S M Echwald
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Biochem Biophys Res Commun 233:248-52. 1997
    ..humans may be caused by leptin resistance mediated through genetic variations in isoforms of the hypothalamic leptin receptor. One hundred and fifty-six obese Danish men with a history of juvenile onset obesity were selected at the ..
  62. ncbi Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line
    K Laud
    Laboratoire de Biologie Cellulaire et Moleculaire, Institut National de la Recherche Agronomique, 78352 Jouy en Josas, Cedex, France
    Mol Cell Endocrinol 188:219-26. 2002
    ..Our results showed the expression of both leptin receptor transcripts in all tumoral tissues examined...
  63. ncbi Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation
    Meng Hsing Wu
    Institute of Clinical Medicine and Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, ROC
    Mol Hum Reprod 8:456-64. 2002
    ..This study was aimed at determining whether leptin and leptin receptor expression differs in eutopic and ectopic endometria collected from laparoscopy and at investigating the ..
  64. ncbi The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
    ..Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR...
  65. ncbi Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans
    Mary Yannakoulia
    Department of Nutrition Dietetics, Harokopio University, 17671 Athens, Greece
    J Clin Endocrinol Metab 88:1730-6. 2003
    The adipocyte-derived hormones leptin [which circulates in a free form and bound to a soluble leptin receptor (sOB-R)], adiponectin, and resistin play a key role in regulating energy homeostasis and metabolism...
  66. ncbi Leptin and leptin receptor in human seminal plasma and in human spermatozoa
    T Jope
    Department of Dermatology, Andrological Unit, University of Leipzig, Leipzig, Germany
    Int J Androl 26:335-41. 2003
    ..01) and supports this finding. Furthermore, a soluble leptin receptor (145 kDa) was found in human seminal plasma in the same specimen...
  67. ncbi Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic whites (n =..
  68. ncbi Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity
    Madhusmita Misra
    BUL 457B, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3486-95. 2004
    ..The soluble leptin receptor (sOB-R) is the main leptin binding protein, and the ratio of serum leptin to sOB-R provides a measure of the ..
  69. ncbi Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents
    J M Guízar-Mendoza
    Unidad de Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Guanajuato, Mexico
    J Hum Hypertens 19:341-6. 2005
    Polymorphisms of leptin receptor (LEPR) may contribute to a common form of obesity and, as a consequence, obesity-related diseases...
  70. pmc Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms
    E V Willett
    Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, UK
    Br J Cancer 93:811-6. 2005
    ..9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL risk, as well as a polymorphism in the energy ..
  71. pmc Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis
    Sandrine Belouzard
    Centre National de la Recherche Scientifique, Unité Propre de Recherche 2511, Institut Pasteur de Lille, Lille Cedex, France
    EMBO J 25:932-42. 2006
    ..We propose that mono-ubiquitin conjugates act as internalization motifs for clathrin-dependent endocytosis of leptin receptor OB-Ra.
  72. ncbi Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women
    Karin Séron
    CNRS 8090 Institut de Biologie de Lille, Institut Pasteur, Lille, France
    Biochem Biophys Res Commun 348:1232-8. 2006
    Animal studies have illustrated the importance of the expression in adipose tissue of the leptin receptor (OB-R), and of SOCS3 an inhibitor of the leptin signaling pathway, in body weight regulation...
  73. ncbi Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns
    Mariken de Krom
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Diabetes 56:276-80. 2007
    ..Obese carriers of common allelic variations in leptin or the leptin receptor gene had an increased risk to display extreme snacking behavior...
  74. ncbi Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
    Una L Fairbrother
    Section of Genomic Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Bone Miner Res 22:544-50. 2007
    ..In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture. Smoking exacerbates this LEPR-associated fracture risk...
  75. ncbi [Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer]
    Cun zhi Han
    Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:136-40. 2007
    To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.
  76. ncbi The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer
    Chien Liang Liu
    Department of General Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    Oncology 72:75-81. 2007
    We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer.
  77. pmc Adaptations to climate in candidate genes for common metabolic disorders
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e32. 2008
    ..Nevertheless, our results are consistent with the idea that climate has been an important selective pressure acting on candidate genes for common metabolic disorders...
  78. doi Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers
    James D Doecke
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 17:1007-12. 2008
    ..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis...
  79. doi Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer
    Christos Yapijakis
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Kifissias and Perikleous Stavrou 9, 11524, Athens, Greece
    J Cancer Res Clin Oncol 135:603-12. 2009
    We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for ..
  80. doi Genetic variation in adipokine genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:933-40. 2009
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC.
  81. doi Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers
    Iztiar Abete
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamploma, Spain
    Arch Med Res 40:306-10. 2009
    Carrying variants on the leptin receptor gene (LEPR) may have an impact on inflammatory and stress markers...
  82. pmc Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy
    Mirko Riolfi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Brain Pathol 20:481-9. 2010
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  83. doi Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects
    Alina Constantin
    Department of Vascular Dysfunctions in Diabetes and Obesity, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 391:282-6. 2010
    We aimed to investigate whether polymorphisms LEP G-2548A and LEPR Q223R in the human leptin (LEP), and leptin receptor (LEPR) genes are associated with obesity and metabolic traits in a sample of Romanian population...
  84. doi The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    Takuro Furusawa
    Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
    Hum Genet 127:287-94. 2010
    ..of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (..
  85. pmc Leptin exacerbates sepsis-mediated morbidity and mortality
    Nathan I Shapiro
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 185:517-24. 2010
    ..endotoxemia and cecal ligation puncture models of sepsis, we observed elevated levels of leptin and soluble leptin receptor (sLR)...
  86. pmc Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 6:e26157. 2011
    Three non-synonymous single nucleotide polymorphisms (Q223R, K109R and K656N) of the leptin receptor gene (LEPR) have been tested for association with obesity-related outcomes in multiple studies, showing inconclusive results...
  87. doi Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways
    Hoon Kyu Oh
    Departments of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea
    Mol Hum Reprod 19:160-8. 2013
    ..This study investigated the expression of the leptin receptor (ObR) in endometrioma tissues and immortalized endometriotic cells, and the effect of leptin on cell growth...
  88. pmc Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica
    Nicole M Mackey-Lawrence
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 81:1460-70. 2013
    Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba ..
  89. ncbi Leptin receptor gene variation and obesity: lack of association in a white British male population
    T Gotoda
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Hum Mol Genet 6:869-76. 1997
    ..Rodents with mutations in the leptin receptor gene develop morbid obesity...
  90. ncbi Divergent signaling capacities of the long and short isoforms of the leptin receptor
    C Bjørbaek
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:32686-95. 1997
    ..Although substantially weaker than OBRl, OBRs is capable of mediating signal transduction via JAK, but these activities are of as yet unknown significance for leptin biology in vivo...
  91. ncbi A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
    N D Quinton
    Biomedical Research Centre, Sheffield Hallam University, UK
    Hum Genet 108:233-6. 2001
    ..These observations indicate that functional variations in the leptin receptor gene are important factors in the regulation of adiposity and BMI.
  92. ncbi Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance
    M Wauters
    Department of Endocrinology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Belgium
    J Clin Endocrinol Metab 86:3227-32. 2001
    ..Leptin inhibits especially the glucose-stimulated insulin secretion from pancreatic cells. The leptin receptor (LEPR) gene could thus play a role in the regulation of glucose and insulin after an oral glucose load...
  93. ncbi Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil
    V S Mattevi
    Genetics Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Int J Obes Relat Metab Disord 26:1179-85. 2002
    ..To investigate associations of polymorphisms in the LEP, LEPR and NPY genes with obesity-related traits in a Brazilian population of European descent...
  94. ncbi Association of leptin receptor polymorphism with insulin resistance
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 924 Westwood Boulevard 335, Los Angeles, CA 90024, USA
    Eur J Endocrinol 150:725-9. 2004
    Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown.
  95. ncbi Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 13:779-86. 2004
    ....
  96. ncbi Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Julie A Ross
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 22:3558-62. 2004
    ..Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might ..
  97. ncbi Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
    Lennart Zabeau
    Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, Belgium
    J Biol Chem 280:22632-40. 2005
    The leptin receptor (LR) complex is composed of a single subunit belonging to the class I cytokine receptor family and exists as a preformed complex...
  98. ncbi The leptin receptor system of human platelets
    G Giandomenico
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 3:1042-9. 2005
    ..study examines the effect of leptin on human platelets, and provides initial insights into the nature of the leptin receptor on these platelets...
  99. ncbi Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study
    T Salopuro
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, Kuopio, Finland
    Int J Obes (Lond) 29:1245-51. 2005
    Genetic variation in leptin receptor (LEPR) gene has been reported to associate with insulin and glucose metabolism and adiposity in different study settings and various populations...
  100. ncbi Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM
    Kyong Soo Park
    Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Department of Internal Medicine, Seoul National University College of Medicine, 110 744 Seoul, Korea
    J Hum Genet 51:85-91. 2006
    ..Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorphisms of the leptin receptor gene (LEPR) ..
  101. pmc Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, Tunisia
    BMC Cancer 6:38. 2006
    ..Leptin exerts its physiological action through its specific receptor (LEPR). We have investigated whether genetic variations in LEP and LEPR have implications for susceptibility to and prognosis in breast carcinoma...

Research Grants65

  1. Barry E Levin; Fiscal Year: 2015
    ..We will utilize these rats, as well as LepRbEGFP mice in which neurons expressing the leptin receptor (Lepr-b) have a fluorescent tag and ob/ob mice without leptin and db/db mice with defective leptin signaling, ..
  2. Lawrence P Reagan; Fiscal Year: 2016
    ..This leptin resistance may be related to a combination of decreased leptin BBB transport and reduced leptin receptor (LepR) signaling...
  3. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Obesity and diabetes can also negatively affect fertility. Thus, it is hoped that our studies may open new fronts for the understanding and for further treatment of reproductive deficits caused by metabolic dysfunctions. ..
  4. Abba J Kastin; Fiscal Year: 2014
    ..The results will be compared with those from astrocyte specific leptin receptor knockout mice, and after pretreatment with the astrocyte inhibitor fluorocitrate...
  5. Sensory Controls of Hyperphagia in Obesity
    Gary Schwartz; Fiscal Year: 2009
    ..abstract_text> ..
  6. Obese diabetic (type II) mouse model without leptin/leptin-receptor defects
    Richard G Peterson; Fiscal Year: 2013
    ..4) Confirm the model's responsiveness to dietary manipulation to maintain the pre-diabetic state as well as to accelerate the progression to frank diabetes. ..
  7. Orexin and Leptin Regulation of Feeding and Addictive Behavior in the VTA
    Michael Scott; Fiscal Year: 2010
    ..The study findings will provide valuble information with which to develop treatment strategies for the prevention of drug use and consumption of calorie dense food. ..
  8. Orexin and Leptin Regulation of Feeding and Addictive Behavior in the VTA
    Michael Scott; Fiscal Year: 2013
    ..abstract_text> ..
  9. Margaret B Allison; Fiscal Year: 2014
    ..At the completion of these studies we hope to gain critical insight into the mechanisms of leptin action in the central nervous system. ..
  10. LEPTIN RECEPTOR AND THE OBESITY/DIABETES SYNDROME
    Streamson C Chua; Fiscal Year: 2010
    ..Leptin circulates and has direct actions in the brain and skeletal muscle by binding to the B isoform of leptin receptor (LEPR-B)...
  11. Abba J Kastin; Fiscal Year: 2014
    ..by applicant): In the third grant cycle of "leptin transport across the BBB", we will focus on the role of leptin receptor (ObR)-positive astrocytes in relaying leptin from blood to the CNS after crossing the blood-brain barrier (..
  12. Virginia D Winn; Fiscal Year: 2014
    ..not differentially expressed in our PE microarray data suggesting that Siglec-6 may serve as the critical leptin receptor in PE...
  13. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  14. Carol Fuzeti Elias; Fiscal Year: 2016
    ..In addition, we will also assess the requirement of leptin signaling in both (PMV and Kiss1) neuronal population (Aim3) for the full rescue of the infertility phenotype of LepR null mice. ..
  15. Xin Yun Lu; Fiscal Year: 2016
    ..infusion of leptin into the hippocampus produces antidepressant-like effects, and ablation of the functional leptin receptor, LepRb, in this brain region induces depressive-like behaviors, suggesting an essential role of LepRb in the ..
  16. Leptin Transport across the BBB: The Role of ObR (+) astrocytes
    Abba J Kastin; Fiscal Year: 2010
    ..third grant cycle of [unreadable]leptin transport across the BBB[unreadable], we will focus on the role of leptin receptor (ObR)- positive astrocytes in relaying leptin from blood to the CNS by crossing the blood-brain barrier (BBB)...
  17. ELIZABETH ANNE GRICE; Fiscal Year: 2014
    ..Furthermore, implementation of the proposed career development plan and completion of these aims will establish the foundation necessary for me to embark on a career as an independent investigator. ..
  18. C Robert Horsburgh; Fiscal Year: 2016
    ..Levofloxacin will be administered with an optimized background regimen (OBR) to address the following Specific Aims: Specific Aim 1: To determine the levofloxacin AUC/MIC that provides the ..
  19. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..The significance of this proposal, specifically with respect-to the identification of possible prevention strategies for adult AML, has important public health implications. ..
  20. Abnormal Energy Homeostasis in ALS
    Robert Kalb; Fiscal Year: 2009
    ..neuron disease of mutant SOD mice prevented or slowed by genetically reducing basal metabolic rate? The Leptin-ObR signaling system controls food intake and basal metabolic rate...
  21. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..circulating leptin, IGF-1 and IGFBP-3 levels and colorectal adenoma risk, 2) assess the association between leptin receptor (LEPR) and IGFBP-3 polymorphisms and colorectal adenomas, and 3) examine the genotype-phenotype relationships ..
  22. Study of Leptin Receptor Deficiency in Fat
    Allan Zhao; Fiscal Year: 2007
    ..We believe that these studies will provide a possible molecular linkage between adipocyte-selective leptin receptor deficiency and type 2 diabetes.
  23. GENETIC AND PATHOLOGIC ALTERATIONS IN MURINE DIABETES
    Richard Quigg; Fiscal Year: 2001
    ..dependent DM characterized by obesity and insulin resistance due to a single nucleotide substitution in the leptin receptor gene (Lepr)...
  24. Electrophysiological Analysis of Leptin Action
    AARON ROSEBERRY; Fiscal Year: 2004
    ..Mice lacking leptin or a functional leptin receptor (ObR) are grossly obese and show other physiological defects, and leptin administration to mice leads to a ..
  25. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
    ..The meeting is planned for 200 participants. Because of limited seating capacity in The Jackson Laboratory's auditorium, the meeting venue will be the Bar Harbor Regency Hotel, where participants will be housed and fed. ..
  26. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
    ..Collectively, these studies will permit genetic and metabolic characterization of key events in the transition from simple obesity to diabesity in thee novel mouse models. ..
  27. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2005
    ..These latter investigations are of particular importance in view of an ongoing NIDDK trial to prevent T1D in humans deemed at high risk by oral insulin treatment. ..
  28. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..Understanding the contributions of diabetes modifying genes in the extended mouse MIHC may identify human HLA orthologs whose presence has recently been established. ..
  29. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..Our hope is that by the end of the grant period, we will be able to provide a pyrrhocoricin-derived peptide for ensuing US Food and Drug Administration-approved preclinical and clinical evaluation against urinary tract infections. ..
  30. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  31. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  32. Role of inositol trisphosphate in preconditioning
    Karin Przyklenk; Fiscal Year: 2004
    ....
  33. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
  34. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  35. Gene Amplification-Sciarid DNA Puffs
    SUSAN GERBI; Fiscal Year: 2006
    ..Information gained from the unique Sciara system should behelpful in understanding the mechanisms used by metazoa to specify an origin and to regulate its activation. ..
  36. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2008
    ..The results could also contribute to the body of heath-related science that influences air quality standards and policies. [unreadable] [unreadable] [unreadable]..
  37. Cellular Basis for Non-Parallel Gonadotropin Release
    Gwen Childs; Fiscal Year: 2005
    ..An understanding of mechanisms that selectively regulate gene expression in these cells will provide important information about how fertility is regulated. ..
  38. ENERGY HOMEOSTASIS IN HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2001
    ..The goal is to identify the cellular and molecular mechanism(s) responsible for the changes in energy metabolism which accompany weight perturbation. ..
  39. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  40. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..in the hypothalamus that encode anorectic and orexigenic peptides, and their interactions with the leptin-leptin receptor axis...
  41. Conference on Obesity
    Rudolph Leibel; Fiscal Year: 2004
    ....
  42. Biogenesis of Eukaryotic Ribosomes
    SUSAN GERBI; Fiscal Year: 2004
    ..The proposed studies should elucidate the importance of dynamic RNA-RNA interactions during ribosome biogenesis, a fundamental process essential for cell growth and viability. ..
  43. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  44. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  45. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  46. Leptin Production and Action in Adipocytes
    Yiying Zhang; Fiscal Year: 2007
    ..Adenovirus-mediated gene transfer will be used to modify leptin receptor function or the rate of leptin production in cultured preadipocytes, which will then be implanted in athymic ..
  47. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  48. Aging, Adenosine and Platelet-Mediated Thrombosis
    Karin Przyklenk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  50. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ....
  51. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002
    ..Results from these studies will define new biological actions of NT-3 and reveal how manipulation of the trophic support of neurons may be useful to treat pathologic neural conditions. ..
  52. GENES CAUSING SPONTANEOUS OBESITY
    Craig Warden; Fiscal Year: 2002
    ..They have already found that spretus and B6 UCP2 differ for 2 amino acids, so uncoupling activity of UCP2 from these strains will be examined. ..
  53. FLOW SHEAR INDUCED NF-KB MEDIATED REGULATION
    Sumathy Mohan; Fiscal Year: 2003
    ..Understanding of NF- kappaB signaling mechanisms in VCAM-1 regulation can also be applied to other inflammatory conditions. ..
  54. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  55. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  56. RAPID ISOLATION OF DIET-RESPONSIVE OBESITY GENES
    Craig Warden; Fiscal Year: 2009
    ..We believe that this study offers the opportunity to identify a gene causing maternal effects on obesity, as well as three other obesity genes, by using well characterized congenic mouse strains. ..
  57. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  58. Regulation of Leptin Production by Gonadotropes
    Gwen Childs; Fiscal Year: 2005
    ..These feasibility studies will thus provide information that will allow us to design future experiments for full funding. ..
  59. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2007
    ..The resulting mechanistic insights may, ultimately, be exploited in the future design of novel therapies for the clinical treatment of recurrent thrombosis. ..
  60. Mesenchymal cells in surgical wound healing
    Nicole Gibran; Fiscal Year: 2008
    ..3. To determine whether bone marrow-derived MSC can reverse diabetes impaired wound healing. 4. To determine whether bone marrow-derived MSC are critical for wound healing. ..
  61. Positional cloning of obesity genes from congenic mice
    Craig H Warden; Fiscal Year: 2010
    ..The long term outcome is that we will identify at least one novel and strong and plausible obesity gene. ..
  62. The Epidemiology of Marine Fatty Acids and Preeclampsia
    Michelle Williams; Fiscal Year: 2006
    ....
  63. CNS Action of Appetite Suppressant Aminosterol
    Rexford S Ahima; Fiscal Year: 2010
    ..Understanding of the central neuronal actions MSI-1436 may elucidate novel targets for the treatment of obesity and related diseases. ..
  64. Diabetic Neuropathy: Implications for Wound Repair
    Nicole Gibran; Fiscal Year: 2006
    ..We will also test the effects of antioxidants in this murine wound model. [unreadable] [unreadable]..